Canonical beta catenin. Medical search. Frequent questions

The CTNNB1 gene provides instructions for making a protein called beta-catenin. (medlineplus.gov)
The beta-catenin protein is also involved in cell signaling as an essential part of the Wnt signaling pathway. (medlineplus.gov)
Certain proteins in this pathway attach (bind) to beta-catenin, which triggers a multistep process that allows the protein to move into the cell nucleus. (medlineplus.gov)
They change single protein building blocks (amino acids) in the beta-catenin protein. (medlineplus.gov)
These mutations lead to an abnormally stable beta-catenin protein that is not broken down when it is no longer needed. (medlineplus.gov)
They cause the beta-catenin protein to be turned on all the time (constitutively active), which leads to the abnormal activation of certain genes. (medlineplus.gov)
This active beta-catenin protein promotes Wnt signaling longer than normal, which leads to the unchecked proliferation of kidney cells and tumor development. (medlineplus.gov)
β-Catenin is a fascinating protein with many important cellular and developmental functions. (chemdiv.com)
The roles of b-catenin are 'classically' defined: as an adhesion protein and as a signaling protein, transducing extracellular signals to the nucleus to modify gene expression. (chemdiv.com)
β -catenin has many binding partners that mediate a diverse set of cellular functions, and the protein probably acts as a 'hub' on which many cellular signaling networks impinge. (chemdiv.com)
This library represents a selection of drug-like compounds aimed at modulating protein-protein interaction (PPI) of β-catenin with different proteins involved in significant physiological processes. (chemdiv.com)
In the absence of Wnt signals, the cytoplasmic catenin beta-1 ( β-catenin ) is associated with a complex including auxin, glycogen synthase kinase 3 ( GSK-3 ), and adenomatous polyposis coli ( APC ) (the APC protein acts as the primary regulator of β-catenin function). (hindawi.com)
In the presence of Wnt signals, the Wnt proteins bind to (frizzled) frizzled receptors ( FZDs ) and low-density lipoprotein receptor-related protein ( LRP ) receptors, leading to the stabilization of β-catenin , its transfer to the nucleus, and the activation of target genes. (hindawi.com)
β-catenin protein is an integral part of the canonical Wnt signaling pathway. (tocris.com)
We demonstrate that this opposing role of nuclear beta-catenin in melanoma is mediated through MITF, a melanoma-specific protein that defines the lineage background of this cancer type. (hud.ac.uk)
Components of the canonical wingless (WNT) pathway, including WNT8b, WNT10a, WNT10b, frizzled 1 and 2 and TCF4 were upregulated at the messenger RNA and protein levels following Cyclin A2 depletion. (cnrs.fr)
Not much is known about RAPGEF5 protein, but we know it is involved in the canonical Wnt pathway, in the transportation of beta-catenin into the nucleus [2]. (biologists.com)
When Wnt is active, a cascade of chemical reactions prevent the degradation of beta-catenin in the cytoplasm, allowing it to bind to a transporter protein to enter the nucleus. (biologists.com)
Our current model suggests that in response to Rap-GDP conversion to Rap-GTP by RAPGEF5, beta-catenin can dissociate from the transporter protein. (biologists.com)
β-Catenin is a 92-kDa protein, originally identified in cell adherens junctions (AJs) where it functions to bridge the cytoplasmic domain of cadherins to a-catenin and the actin cytoskeleton. (ptglab.com)
beta-Catenin, also known as CTNNB1, is a cadherin-associated protein that is involved in the regulation of cell adhesion. (bio-techne.com)
This multifunctional protein is also implicated in the canonical Wnt signal transduction pathway, acting as a transcriptional co-activator. (bio-techne.com)
Kaposi's sarcoma-associated herpesvirus G-protein coupled receptor activates the canonical Wnt/beta-catenin signaling pathway. (ac.ir)
20. Morrison JA, Raab-Traub N. Roles of the ITAM and PY motifs of Epstein-Barr virus latent membrane protein 2A in the inhibition of epithelial cell differentiation and activation of {beta}-catenin signaling. (ac.ir)
Hepatitis B virus X protein is essential for the activation of Wnt/beta-catenin signaling in hepatoma cells. (ac.ir)
The ankyrin repeat protein Diversin recruits Casein kinase Iepsilon to the beta-catenin degradation complex and acts in both canonical Wnt and Wnt/JNK signaling. (knaw.nl)
The canonical pathway will be the only 1 to involve beta-catenin, which can be the TCF/LEF binding protein responsible for improved transcription and EMT [57,58]. (scdinhibitor.com)
Canonical WNT signaling occurs via beta-catenin (CTNNB1), a multi-function protein required for prostate development. (wisc.edu)
Nefopam targets β-catenin protein level in mesenchymal cells in-vitro and in-vivo. (dcchemicals.com)
ZW4864 (free base) is an orally active and selective β catenin/B-Cell lymphoma 9 protein−protein interaction (β catenin/BCL9 PPI) inhibitor. (dcchemicals.com)

Involved in positive regulation of canonical Wnt signaling pathway. (nih.gov)
Ligand for members of the frizzled family of seven transmembrane receptors that functions in the canonical Wnt/beta-catenin signaling pathway (By similarity). (nih.gov)
Functions in the canonical Wnt/beta-catenin signaling pathway. (xenbase.org)
The canonical Wnt/beta-catenin signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. (xenbase.org)
A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. (xenbase.org)
The canonical Wnt signaling pathway stabilizes the transcriptional coactivator BETA CATENIN. (ouhsc.edu)
Zinc protoporphyrin suppresses cancer cell viability through a heme oxygenase-1-independent mechanism: the involvement of the Wnt/ß-catenin signaling pathway. (ouhsc.edu)
Most of the oncogenic viruses modulate the canonical Wnt signaling pathway. (ac.ir)
Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. (oftalmic.ru)
Beta-catenin acts as an intracellular signal transducer in the Wnt signaling pathway. (plurisomes.com)
Wnts in this class have been shown to signal in a non-canonical Wnt signaling pathway, the Wnt/Ca 2+ pathway (Wnt-5a, -4, -11). (biomedcentral.com)
E-7386 (E7386) is a potent, orally active modulator of CBP/beta-catenin, disrupts the interaction and inhibits canonical Wnt signaling pathway /TCF reporter gene activity in LiCl-stimulated HEK-293 and MDA-MB-231 with IC50 of 55 and 73 nM, respectively. (dcchemicals.com)
The signaling pathway is initiated by the binding of WNT PROTEINS to cell surface WNT RECEPTORS which interact with the AXIN SIGNALING COMPLEX and an array of second messengers that influence the actions of BETA CATENIN. (bvsalud.org)

For instance in colon and liver cancer canonical Wnt signalling produces increased cytoplasmic and nuclear localised beta-catenin, which correlates with invasion and poor prognosis. (hud.ac.uk)
21. Everly DN, Jr., Kusano S, Raab-Traub N. Accumulation of cytoplasmic beta-catenin and nuclear glycogen synthase kinase 3beta in Epstein-Barr virus-infected cells. (ac.ir)

Once in the nucleus, beta-catenin interacts with other proteins to control the activity (expression) of particular genes. (medlineplus.gov)
Speaking more specifically, β-catenin is an integral structural component of cadherin-based adhesive junctions as well as it a key nuclear effector of canonical in nucleus Wnt signaling. (chemdiv.com)
Accumulation of β-catenin in the cell cytoplasm prompts its translocation to the nucleus, where it interacts with members of the TCF/LEF family of transcription factors and induces the transcription of Wnt target genes. (tocris.com)
Beta-catenin then accumulates in the nucleus where it interacts with its transcriptional co-activators, members of the Lymphoid Enhancer Factor/T Cell Factor (LEF/TCF) family of high mobility group DNA binding proteins to regulate gene expression [ 1 ]. (biomedcentral.com)
CWP232228, a highly potent selective Wnt/β-catenin signaling inhibitor, antagonizes binding of β-catenin to T-cell factor (TCF) in the nucleus. (dcchemicals.com)

Downstream of beta-catenin MITF not only suppresses the Rho-GTPase-regulated cell morphology of invading melanoma cells, but also interferes with beta-catenin-induced expression of the essential collagenase MT1-MMP, thus affecting all aspects of an invasive phenotype. (hud.ac.uk)
Besides its essential role in the AJs, β-catenin is also a key downstream component of the canonical Wnt pathway that plays diverse and critical roles in embryonic development and adult tissue homeostasis. (ptglab.com)
Many downstream target genes of the Wnt/beta-catenin pathway have been identified. (biomedcentral.com)
Many downstream gene targets of the canonical Wnt/beta-catenin pathway have been identified http://www.stke.org . (biomedcentral.com)

XPNPEP3 is a novel transcriptional target of canonical Wnt/β-catenin signaling. (nih.gov)
Essential role of BCL9-2 in the switch between beta-catenin's adhesive and transcriptional functions. (knaw.nl)

Upon binding to this complex, β -catenin is phosphorylated, thus being labeled for degradation in the proteasome. (hindawi.com)

β-catenin forms a complex with T-cell factor ( TCF ) /lymphoid enhancer factor ( LEF ) transcription factors and cofactors such as histone acetyltransferase p300 (p300), CBP, BCL9, and pygopus, to transcribe Wnt signaling target genes such as Cyclin D1 , C-Myc , and survivin [ 9 , 12 - 15 ]. (hindawi.com)
Aberrant TCF-β-catenin signaling is also evident in many cancers, and results in altered expression of genes controlling cell proliferation, differentiation, migration and apoptosis. (tocris.com)
Nuclear beta-Catenin activates the TCF/LEF family of transcription factors, inducing the transcription of pro-mitotic genes. (bio-techne.com)
ICG-001 is a small-molecule antagonist of b-catenin/TCF-mediated transcription (IC50 = 3 uM) and specifically downregulates the expression of a subset of b-catenin/TCF-responsive genes. (dcchemicals.com)

There are three Wnt signaling pathways that are well identified, including the canonical or Wnt/β-catenin dependent pathway, the noncanonical or β-catenin-independent planar cell polarity (PCP) pathway, and the noncanonical Wnt/Ca2+ pathway. (ac.ir)
The three pathways will be the canonical Wnt/beta-catenin pathway, the noncanonical planar cell polarity (PCP) pathway, along with the noncanonical Wnt/calcium pathway. (scdinhibitor.com)

The Wnt/β-catenin pathway is also involved in the activation of other intracellular messengers such as calcium fluxes, JNK, and SRC kinases. (ptglab.com)
Intracellular beta-catenin levels are maintained through continuous creation and destruction, the processes of that are suggested to be regulated differently in between our parity groups. (scdinhibitor.com)

In Cyclin A2-depleted normal murine mammary gland (NMuMG) cells expressing RasV12, we found that beta-catenin was liberated from the cell membrane and cell-cell junctions and underwent nuclear translocation and activation. (cnrs.fr)

β-catenin is a component of the complex cadherin complex whose stabilization is required to activate Wnt/β-catenin signaling. (chemdiv.com)

A prominent example for the decisive impact of lipid rafts on signaling is LRP6, whose localization to the same lipid rafts domain as the kinase CK1γ is crucial for its successful phosphorylation and the subsequent activation of the signalosome, hence WNT/β-catenin signaling. (frontiersin.org)

BMP-9-induced osteogenic differentiation of mesenchymal progenitors requires functional canonical Wnt/beta-catenin signalling. (uchicago.edu)
Activation of the canonical Wnt pathway leads to loss of hematopoietic stem cell repopulation and multilineage differentiation block. (ox.ac.uk)
Constitutive activation of canonical Wnt signaling therefore causes multilineage differentiation block and compromised hematopoietic stem cell maintenance. (ox.ac.uk)

β-catenin is a multipurpose and evolutionarily conserved molecule that plays a critical role by metazoans in a variety of processes in development and homeostasis. (chemdiv.com)

ChemDiv proposes the new library of beta-catenin inhibitors/modulators. (chemdiv.com)

Mutations in β-catenin, axin and APC have been discovered in numerous cancers, and other members of the canonical pathway may also contribute to misregulation of Wnt signaling. (tocris.com)
The beta-catenin destruction complicated starts using the binding of GSK3 to Axin, which leaves GSK3's active website open to phosphorylate beta-catenin. (scdinhibitor.com)
La vía de señalización se inicia con la unión de las PROTEÍNAS WNT a la superficie de las células de los RECEPTORES WNT que interactúan con el COMPLEJO DE SEÑALIZACIÓN AXIN y una serie de segundos mensajeros que influyen en las acciones de la BETA-CATENINA. (bvsalud.org)

To analyze whether and how the quantitative ratio between receptor and rafts affects LRP6 phosphorylation and WNT/β-catenin pathway activation, we present a computational modeling study, that for the first time employs realistic raft numbers in a compartment-based pathway model. (frontiersin.org)
Even though LRP6 is homogenously distributed in the membrane and only a minor fraction is raft-associated, its localization to lipid rafts is vital for the activation of the LRP6 signalosome, hence wnt/β-catenin signaling. (frontiersin.org)
Here, we apply computational modeling to analyze whether and how the quantitative ratio between receptor and rafts affects LRP6 phosphorylation and WNT/β-catenin pathway activation. (frontiersin.org)
Activation of Xwnt11 is induced in an immediate-early fashion by Xbra and its expression in vivo is abolished by a dominant-interfering form of Xbra , Xbra -En(R). Overexpression of a dominant-negative form of Xwnt11 , like overexpression of Xbra -En(R), inhibits convergent extension movements. (xenbase.org)
This suggests that a WNT-independent mechanism of beta-catenin activation via phospholipase C is involved in the EMT induced by Cyclin A2 depletion. (cnrs.fr)
The canonical Wnt pathway contains the beta-catenin destruction complex, which is normally down-regulated or disrupted following the activation of Wnt signaling. (scdinhibitor.com)

Transgenic expression of a canonical Wnt inhibitor, kallistatin, is associated with decreased circulating CD19+ B lymphocytes in the peripheral blood. (ouhsc.edu)
iCRT3 is an inhibitor of both Wnt and β-catenin-responsive transcription. (dcchemicals.com)
KYA1797K is a highly potent and selective Wnt/β-catenin inhibitor with IC50 of 0.75 µM (TOPflash assay). (dcchemicals.com)
LF3 is a specific inhibitor of canonical Wnt signaling by disrupting the interaction between β-catenin and TCF4 with an IC50 less than 2 μM. (dcchemicals.com)
PNU-74654 is an inhibitor of Wnt/β-catenin pathway with an IC50 of 129.8 μM in NCI-H295 cell. (dcchemicals.com)
β-catenin-IN-2 is a potent β-catenin inhibitor, compound H1B1, extracted from patent US20150374662A1. (dcchemicals.com)
PRI-724 (C-82 prodrug, ICG-001 analog) is a potent and specific inhibitor that disrupts the interaction of β-catenin and CBP. (dcchemicals.com)
GB1874 is an inhibitor of the Wnt pathway that targets the β-catenin-TCF4 interaction.GB1874 affected the proliferation and stemness of Wnt-addicted colorectal cancer (CRC) cells in vitro.GB1874 inhibited the growth of CRC tumor xenografts in vivo. (dcchemicals.com)

Immunofluorescent analysis of (-20°C Methanol) fixed MCF-7 cells using CoraLite®555 Beta Catenin antibody (CL555-51067) at dilution of 1:100. (ptglab.com)
Immunofluorescent analysis of (4% PFA) fixed human liver cancer tissue using CoraLite®555 Beta Catenin antibody (CL555-51067) at dilution of 1:100, CoraLite® Plus 647 CD3 antibody (CL647-60181, Clone: 3F3A1, Magenta), CoraLite® Plus 488 CD163 antibody (CL488-16646, green). (ptglab.com)

An imbalance in the structural and signaling properties of β-catenin often leads to disease and unregulated growth associated with cancer and metastasis. (chemdiv.com)

these in turn inhibit the destruction complex responsible for degrading β-catenin, which includes GSK-3 . (tocris.com)
Our evaluation showed an increased methylation of LRP5 within parous females, which suggests a decreased expression of LRP5/6 plus a decreased cellular capability to stop the beta-catenin destruction complex within this way. (scdinhibitor.com)

Wnt/β-catenin signaling is a branch of a functional network that is involved in a broad range of biological systems including stem cells, embryonic development and adult organs. (chemdiv.com)
Where is canonical Wnt signalling active during embryonic development? (biologists.com)

CHD8 is an independent prognostic indicator that regulates Wnt/ß-catenin signaling and the cell cycle in gastric cancer. (ouhsc.edu)

A novel viral mechanism for dysregulation of beta-catenin in Kaposi's sarcoma-associated herpesvirus latency. (ac.ir)

Deregulation of components involved in Wnt/β-catenin signaling has been implicated in a wide spectrum of diseases including a number of cancers and degenerative diseases. (chemdiv.com)
We discovered that in contrast to its function in other cancers, in melanoma, beta-catenin blocks invasion. (hud.ac.uk)
Uclear beta-catenin in about 60 of breast cancers. (scdinhibitor.com)

ZW4864 (free base) inhibits β catenin/BCL9 PPI with a Ki value of 0.76 μM and an IC50 value of 0.87 μM. (dcchemicals.com)

R-spondin 2 synergizes with canonical WNT to activate beta-catenin. (wikipedia.org)
Wnts in this functional class activate the canonical Wnt/beta-catenin pathway (Wnt-1, -3A, and -8). (biomedcentral.com)
Vertebrate Wnts signal through frizzled receptors that in some experimental contexts (e.g., without co-expressing LRP5/6) preferentially activate the Wnt/beta-catenin or Wnt/Ca 2+ pathways [ 5 ]. (biomedcentral.com)

FH535 is a compound that suppresses both Wnt/beta-catenin and peroxisome proliferator-activated receptor (PPAR) signaling. (dcchemicals.com)

Complementary Wnt Sources Regulate Lymphatic Vascular Development via PROX1-Dependent Wnt/ß-Catenin Signaling. (ouhsc.edu)

β-catenin also plays an essential role in cell-cell adhesion, and is thought to maintain the attachment of stem cells to their niche by interacting with membrane-bound cadherin and α-catenin. (tocris.com)

Antagonist of the Tcf/β-catenin complex. (tocris.com)

In melanoma, beta-catenin is a suppressor of invasion. (hud.ac.uk)
In summary, the cell-type-specific presence of MITF in melanoma affects beta-catenin's pro-invasive properties otherwise active in colon or liver cancer. (hud.ac.uk)

All the diversity of catenins forms a complex functional network. (chemdiv.com)

CL555-51067 targets Beta Catenin in IF applications and shows reactivity with human, mouse, rat, pig samples. (ptglab.com)

The recently described role of the Wnt/β-catenin pathway in the regulation of immune cell infiltration of microenvironment tumor resumes interest because of its potential impact to rection of immune therapy. (chemdiv.com)
regulation of gastrulation movements via Dishevelled , but not through the canonical Wnt pathway. (xenbase.org)

The Wnt pathway mediates the biological processes of the canonical or non-canonical pathway, depending on the involvement of β-catenin in signal transduction. (chemdiv.com)
Several studies suggested an involvement of lipid rafts in the WNT /β-catenin pathway. (frontiersin.org)

A representative example of a 'druggable' 'hot spots' included specific topological features of the β -catenin interaction. (chemdiv.com)

This canonical pathway has been shown to influence developmental processes such as cell proliferation and body axis specification, as well as carcinogenesis. (tocris.com)

The Wnt cascade consists of canonical and non-canonical pathways, of which the former is believed to be involved in self-regeneration. (hindawi.com)

This frees beta-catenin, allowing it to interact with DNA-binding proteins to alter gene expression. (biologists.com)

Beta-catenin plays an important role in sticking cells together (cell adhesion) and in communication between cells. (medlineplus.gov)

Excess beta-catenin promotes the uncontrolled proliferation of cells, allowing the formation of desmoid tumors. (medlineplus.gov)

The primary structure of beta-catenin consists of an NH2-terminal domain (NDT), a central region represented by 12 Arm-repeats (R1-12), and a COOH-terminal end (CTD). (chemdiv.com)

Crosstalk between NF-kappaB and beta-catenin pathways in bacterial-colonized intestinal epithelial cells. (uchicago.edu)

We report here activated canonical Wnt signaling in the hematopoietic system through conditional expression of a stable form of beta-catenin. (ox.ac.uk)

Nussе and Varmus identified components of the Wnt/β-catenin pathway in 1982 in a study of oncogenic breast tumor viral diseases (MMTV) [1]. (chemdiv.com)

This inhibition can be rescued by Dsh , a component of the Wnt signalling pathway and also by a truncated form of Dsh which cannot signal through the canonical Wnt pathway involving GSK-3 and (beta)-catenin. (xenbase.org)

Among its many activities, beta-catenin appears to play an important role in the normal function of hair follicles, which are specialized structures in the skin where hair growth occurs. (medlineplus.gov)

This article presents the roles of the Wnt/β-catenin pathway in cancer and current therapeutic strategies involving this pathway. (chemdiv.com)

Anatomy10

Diseases6

Chemicals and Drugs44

Analytical, Diagnostic and Therapeutic Techniques and Equipment7

Phenomena and Processes10

Disciplines and Occupations1

Information Science2

Protein30

Signaling Pathway13

Cytoplasmic2

Nucleus5

Downstream4

Transcriptional2

Degradation1

Genes4

Planar cell pol2

Intracellular2

Nuclear1

Stabilization1

Kinase1

Differentiation3

Evolutionarily conserved1

Modulators1

Axin3

Activation6

Inhibitor8

Antibody2

Metastasis1

Destruction complex2

Embryonic development2

Regulates1

Mechanism1

Cancers3

Inhibits1

Activate3

Suppresses1

Dependent1

Cadherin1

Antagonist1

Melanoma2

Functional1

Targets1

Regulation2

Involvement2

Interaction1

Carcinogenesis1

Cascade1

Gene expression1

Plays1

Proliferation1

Consists1

Epithelial1

Stable1

Components1

Signal1

Role1

Roles1