Cannabinoids induce apoptosis. Medical search. Frequent questions

Cannabidiol Ameliorates Monocrotaline-Induced Pulmonary Hypertension in Rats. (nih.gov)
The administration of the non-psychotropic cannabinoid CBD ( cannabidiol ) induces selective apoptosis in hepatic stellate cells (HSCs), according to preclinical findings reported in the journal Cell Death and Disease. (jackherer.com)
There is a growing body of anecdotal and scientific evidence that the "major cannabinoids" tetrahydrocannabinol (THC) and cannabidiol (CBD), certain "minor cannabinoids" (some without a name), and other cannabis compounds have antineoplastic action against cancer cells. (projectcbd.org)
They further revealed that apoptosis was induced by cannabidiol as shown by increased subG0/G1 and apoptosis through annexin V. Apoptosis was confirmed by overexpression of p53, caspase 3 and bax. (biomedcentral.com)
In conclusion, these data suggest that cannabidiol rather than Cannabis sativa crude extracts prevent cell growth and induce cell death in cervical cancer cell lines. (biomedcentral.com)
CBD (cannabidiol) is the second most prevalent cannabinoid - after tetrahydrocannabinol (THC) - and is usually extracted from hemp, a strain of the Cannabis sativa plant that contains a high percentage of CBD. (dsm.com)
Two of the major cannabinoids found in cannabis, tetrahydrocannabinol (THC) and cannabidiol (CBD), activate the cannabinoid 1 (CB1) and cannabinoid 2 (CB2) receptors of the endocannabinoid system. (qualifyingconditions.com)
Cannabinoids, such as delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD), have potential therapeutic benefits in various medical conditions. (cannabisclinicians.org)
Cannabidiol (CBD) is a nonintoxicating cannabinoid extracted from the cannabis plant that is used for medicinal purposes. (cannabisclinicians.org)
The total cannabinoid content in the dry products averaged 14,960mg kg 1, with CBD&CBDA (sum of cannabidiol (CBD) and cannabidiolic acid (CBDA)) being the major compo- nent, accounting for 87% of the total cannabinoid content. (cannabisclinicians.org)
Younger hemp flowers contain an abundance of CBG, but as the plant ages, the molecule transforms into other cannabinoids, including delta-9 tetrahydrocannabinol (THC), cannabidiol (CBD), and cannabichromene (CBC). (justkana.com)

Activation of the cannabinoid receptor CB1 or CB2 in different tissues, including skin, inhibit FAAH, and thereby increases endocannabinoid levels. (wikipedia.org)
Thus, cannabinoids, CBD and DMH-CBD inhibit the NF-kB, but in different ways. (news-medical.net)
According to their findings , cannabinoid administration was able to inhibit cancerous growth, prevent its spread, and even induce cancer cell apoptosis in live animal models. (medicaljane.com)
specifically, evidence showing that cannabinoids inhibit neuroinflammation and that immune cells express the entire machinery that constitutes a functional cannabinoid signaling system. (420magazine.com)
They determined that cannabinoids inhibit cancer cell proliferation, induced cancer cell apoptosis and impair tumor angiogenesis. (morethanshipping.com)
Cannabinoids inhibit glioma cell invasion by down-regulating matrix metalloproteinase-2 expression. (caplancannabis.com)
THC and CBD have been shown to inhibit the progression of cancers located in the breast, lung, prostate, and colon in animal models, suggesting that the cannabinoids may also be effective at mediating cancer cell death in human subjects35,53,63,74. (qualifyingconditions.com)
Cannabinoids, especially THC, have been shown to inhibit antitumor immunity. (royalseedsboutique.com)
Other cannabinoids are able to stimulate apoptosis and inhibit angiogenesis. (royalseedsboutique.com)
The study by Manuel Guzman of Madrid Spain found that cannabinoids, the active components of marijuana, inhibit tumor growth in laboratory animals. (wakeup-world.com)
Cannabinoids, the active components of marijuana, inhibit tumor growth in laboratory animals and also kill cancer cells. (wakeup-world.com)

Potential synergistic effects of various combinations including these compounds were tested by measuring cancer cell proliferation and apoptosis. (frontiersin.org)
Purified cannabinoids have been reported to prevent proliferation, metastasis, and induce apoptosis in a variety of cancer cell types. (nih.gov)
Cannabinoids are a class of pharmacologic compounds that offer potential applications as antitumor drugs, based on the ability of some members of this class to limit inflammation, cell proliferation, and cell survival. (aacrjournals.org)
Cannabinoids, interacting through the endocannabinoid system (ECS), have been shown to affect a variety of cellular pathways involved in cancer cell proliferation, apoptosis, and metastasis (Velasco et al. (caplancannabis.com)
Purified cannabinoids have been shown to prevent proliferation and induce apoptosis in colorectal carcinoma cell lines", claims the abstract of the study. (themarijuanaherald.com)

C. sativa compounds interact synergistically for cytotoxic activity against colon cancer cells and induce cell cycle arrest, apoptotic cell death, and distinct gene expression. (nih.gov)
Cannabinoid refers to a group of chemicals naturally found in the marijuana plant Cannabis sativa L. and includes compounds that are either structurally or pharmacologically similar to Δ(9)-tetrahydrocannabinol or those that bind to the cannabinoid receptors. (aacrjournals.org)
That?s why they named it the Endocannabinoid System (endo means internal and cannabinoids are compounds found in the cannabis plant). (911weknow.com)
The vast majority of the existing research is on how specific cannabinoids kill cancer, but a growing body of work is revealing how the entourage of compounds found in whole-plant cannabis kills cancer. (projectcbd.org)
Although most of the studies presented here demonstrated the antineoplastic effects of individual or isolated cannabinoids, most of this research points to what lay healers and patients who make and use their own cannabis oil already know: the whole cannabis plant, including hemp varieties, every part of them, contain antineoplastic compounds that together kill cancer. (projectcbd.org)
This review discusses the anti-inflammatory properties of cannabinoid compounds at molecular, cellular and whole animal levels, first by examining the evidence for anti-inflammatory effects of cannabinoids obtained using in vivo animal models of clinical neuroinflammatory conditions, specifically rodent models of multiple sclerosis, and second by describing the endogenous cannabinoid (endocannabinoid) system components in immune cells. (420magazine.com)
Aside from these two receptors, evidence exists supporting the presence of yet uncloned cannabinoid receptors, a hypothesis predominantly based on pharmacological activity of cannabinoid compounds in CB1 and CB2 receptor-deficient mice or following the administration of 'selective' CB1 and CB2 receptor antagonists (Jarai et al. (420magazine.com)
2003). Here cannabinoids are defined as ingredients of the cannabis plant or other compounds that bind to and activate cannabinoid receptors, and Table 1 summarizes their pharmacological properties. (420magazine.com)
1995). There are notable studies showing the anti-inflammatory properties of cannabinoid-like compounds, such as Δ9-tetrahydrocannabinol (THC) metabolites and the endogenous compound palmitoylethanolamide. (420magazine.com)
Since these compounds do not act through known cannabinoid receptors (Dajani et al. (420magazine.com)
Cannabinoids comprise of (a) the active compounds of the Cannabis sativa plant, (b) endogenous as well as (c) synthetic cannabinoids. (oncotarget.com)
Cannabinoids are the active compounds of this marijuana plant. (oncotarget.com)
Cannabinoid is a family of complex chemicals (terpenophenolic compounds) that exert most of their actions by binding to and activating specific Gαi protein-coupled receptors named as cannabinoid receptor, CB1 (Central receptor) and CB2 (Peripheral receptor) respectively [ 4 - 5 ]. (oncotarget.com)
These eighty compounds are specifically known as cannabinoids. (potmy.com)
Cannabinoids relieve symptoms of illness by attaching to receptors in the brain that look for similar compounds that occur in the human body, like dopamine. (potmy.com)
The cannabis plant contains hundred of compounds, some of which are cannabinoids. (dsm.com)
Cannabinoids are compounds found in the cannabis sativa plant. (cannabisclinicians.org)
Although neither cannabinoid is inherently better than the other, the two compounds do have some distinct differences. (justkana.com)

In order to understand the anti-inflammatory potential of cannabinoids in clinical neuroinflammation, it is necessary to examine their anti-inflammatory effects in animal models. (420magazine.com)
As researchers look for innovative treatment options, the therapeutic potential of cannabinoids has gained significant attention. (caplancannabis.com)

The diversified effects of cannabinoids are now known to be mediated through the activation of G-protein-coupled receptors that are normally bound by a family of endogenous ligands, the endocannabinoids ( 1 ). (aacrjournals.org)
Endocannabinoids (eCBs) are endogenous lipid ligands that bind to cannabinoid receptors that also mediate the effects of marijuana. (degruyter.com)
Some can activate the cannabinoid receptors type-1 and -2 (CB1 and CB2), that are part of the endocannabinoid system (ECS), alongside the endocannabinoids and their metabolic enzymes. (cannabisclinicians.org)
Endocannabinoids are endogenously-produced cannabinoids that are involved in a variety of physiological processes (including pain-sensation and memory) through the activation of cannabinoid receptors [ 1 ]. (biomedcentral.com)
Evidence suggests that endocannabinoids might suppress cancer cell viability through the activation of classic cannabinoid receptors such as cannabinoid receptor-1/2 (CB1 and CB2) and vanilloid receptor-1 (VR1). (biomedcentral.com)
THC that targets cannabinoid receptors CB1 and CB2 is similar in function to endocannabinoids, which are cannabinoids that are naturally produced in the body and activate these receptors. (wakeup-world.com)

First, they induced tumor growth in a group of nude mice. (medicaljane.com)
Cannabinoids are proven to reduce cancer cells and tumor growth. (morethanshipping.com)
The reversal of this THC-induced tumor growth is achieved by neutralizing mAb anti-IL-10. (royalseedsboutique.com)

Cannabinoids lead to apoptosis of pancreatic tumor cells via a CB 2 receptor. (medicaljane.com)
In conclusion, the Spanish researchers determined, "cannabinoids lead to apoptosis of pancreatic tumor cells via a CB 2 receptor" They went on to report that their findings could spur the beginning of "a new therapeutic approach for the treatment of pancreatic cancer. (medicaljane.com)
The potential antineoplastic effects of cannabinoids, including epigenetic modifications that may lead to apoptosis and prevention of cancer cell migration, are still under investigation and are not yet clinically validated (Blázquez et al. (caplancannabis.com)

A study published by the US National Library of Medicine , conducted by Harvard Medical School, they investigated the role of cannabinoid receptors in Lung Cancer cells. (morethanshipping.com)
Since chronic inflammation is a known risk factor for colorectal cancer, the researchers decided to look into the role of cannabinoid receptors in a mouse model of colon cancer. (naturallyhealingmd.com)

More than 15,000 peer reviewed scientific articles have been published on the chemical and pharmacologic uses of cannabis and cannabinoids (CBD). (totalhealthmagazine.com)

Cannabinoids exert their effects through the endocannabinoid system (ECS) that comprises cannabinoid receptors (CB1, CB2), endogenous ligands, and metabolizing enzymes. (therichardrosereport.com)
These anti-proliferative effects seemed to be mediated in a cannabinoid receptor-independent manner, since the antagonist of cannabinoid receptor-1 (CB1) and vanilloid receptor-1 (VR1), two endocannabinoid receptors, did not reverse the ability of DHEA and NALA to induce cell death. (biomedcentral.com)

It explored the pathways cannabinoids use on a cellular level to bring about these results. (marijuanadoctors.com)
These findings showed that YQRG improved CCl 4 -induced liver fibrosis through multiple mechanisms and pathways, offering critical insight into the YQRG-related therapeutic mechanism and promoting further research into its potential application. (biomedcentral.com)
They do so by modulating key cell-signalling pathways, thereby inducing direct growth arrest and death of tumor cells, as well as by inhibiting the growth of blood vessels that supply the tumor. (wakeup-world.com)

The locks are called cannabinoid receptors which are located throughout the brain and body. (911weknow.com)

Other N-acylethanolamines, such as N-oleoylethanolamine and N-palmitoylethanolamine The sleep-inducing lipid oleamide The N-acyltaurines, which are agonists of the transient receptor potential (TRP) family of calcium channels. (wikipedia.org)
In particular, emerging evidence suggests that agonists of cannabinoid receptors expressed by tumor cells may offer a novel strategy to treat cancer. (aacrjournals.org)
Potential application of cannabinoids as anti-tumor drugs is an exciting prospect, because cannabinoid agonists are being evaluated now to treat the side-effects of chemotherapy and radiation therapy," DuBois said. (naturallyhealingmd.com)

Despite the long history of cannabinoid use for medicinal and ritual purposes, an endogenous system of cannabinoid-controlled receptors, as well as their ligands and the enzymes that synthesise and degrade them, was only discovered in the 1990s. (thctotalhealthcare.com)
Cannabinoids are a group of ligands that serve a variety of cell-signaling roles. (naturallyhealingmd.com)

Finally, because of their impaired ability to degrade anandamide, FAAH KOs also display supersensitivity to exogenous anandamide, a cannabinoid receptor (CB) agonist. (wikipedia.org)
So when you consume cannabis, the THC and CBD are able to fit into the cannabinoid receptors in the same way that anandamide and 2-AG do. (911weknow.com)
Anandamide Induces Apoptosis in Human Cells via Vanilloid Receptors. (caplancannabis.com)
The eCB system is comprised of eCBs, anandamide, and 2-arachidonoyl glycerol, their cannabinoid-1 and cannabinoid-2 receptors (CB 1 and CB 2 , respectively), and the enzymes involved in their biosynthesis and degradation. (degruyter.com)

The therapeutic effects of cannabinoids have been well-documented, but the effect of cannabinoids on the immune system is still not explored to a great extent. (news-medical.net)
In this review article, we will focus on a broad range of cannabinoids, their receptor dependent and receptor independent functional roles against various cancer types with respect to growth, metastasis, energy metabolism, immune environment, stemness and future perspectives in exploring new possible therapeutic opportunities. (oncotarget.com)
This study evaluated the therapeutic effect of YQRG on carbon tetrachloride (CCl 4 )-induced liver fibrosis in rats and its molecular mechanism. (biomedcentral.com)
An International Journal of Molecular Sciences study has found that cannabinoids have a toxic effect on colon polyps, indicating therapeutic potential in battling colon cancer cells. (themarijuanaherald.com)

Another 2006 study entitled "Delta9-tetrahydrocannabinol-induced apoptosis in Jurkat leukemia T cells is regulated by translocation of Bad to mitochondria" confirmed THC causes death to cancer cells found in leukemia patients. (marijuanadoctors.com)
To date, more than 60 plant-derived cannabinoid molecules have been identified in marijuana [ 2 ], among which only Δ 9 -tetrahydrocannabinol (THC) is responsible for its psychoactive properties [ 3 ]. (degruyter.com)
One such compound is tetrahydrocannabinol, which is the main active cannabinoid in cannabis. (royalseedsboutique.com)

THC binds to two types of cannabinoid receptors, CB1 and CB2. (projectcbd.org)

Although marijuana cannabinoids have been shown to exert immunosuppression in adults, virtually nothing is known about the effects of marijuana use during pregnancy on the developing immune system of the fetus and during postnatal life. (aspetjournals.org)
This 2002 study explored how cannabinoids in marijuana could be used to treat tumors of immune origin. (marijuanadoctors.com)
This is one of the main reasons why certain strains of medical marijuana are bred to have different amounts of each cannabinoid and are recommended for different conditions. (potmy.com)
It is probably the best known cannabinoid present in medical and recreational marijuana. (potmy.com)
External cannabinoids include manmade versions and those present in plants, most famously the active ingredient in marijuana (THC). (naturallyhealingmd.com)

Studies in cells and animals and genetic studies in humans have shown that inhibiting FAAH may be a useful strategy to treat anxiety disorders, as inhibition produce analgesic, anxiolytic, neuroprotective, and anti-inflammatory effects by elevated N-acylethanolamines (NAE's) and their activation of cannabinoid receptors. (wikipedia.org)
Interestingly, the researchers used a cell culture experiment to determine that pancreas cancer cells express an increased number of cannabinoid receptors. (medicaljane.com)
With a few exceptions, tumor cells throughout the body have cannabinoid receptors on their surface, and THC can bind to these receptors and induce apoptosis or programmed cell death. (projectcbd.org)
Either CB1, CB2, or both must be present in the tumor cells for THC to induce apoptosis in the tumor. (projectcbd.org)
A study published in the US National Library of Medicine illustrates a decrease in Prostate Cancer cells by acting through cannabinoid receptors. (morethanshipping.com)
There are cannabinoid receptors on many cells throughout the body, including the brain, lungs, liver, kidneys and various part of our immune system. (totalhealthmagazine.com)
The results showed that YQRG effectively alleviated CCl 4 -induced liver injury and fibrosis in rats, including observations of improved liver function, decreased activity of hepatic stellate cells (HSCs), and decreased extracellular matrix (ECM) deposition. (biomedcentral.com)
Cannabinoids can block cell growth, progression of cell cycle and induce apoptosis selectively in tumour cells. (therichardrosereport.com)
Cannabinoid-induced cell death in endometrial cancer cells: involvement of TRPV1 receptors in apoptosis. (leaf411.org)
From these findings, we suggest that ROS production induced by the 5-LO pathway mediates the anti-cancer effects of DHEA and NALA on HNSCC cells. (biomedcentral.com)
Cannabinoids previously had been shown to kill cancer cells in lab experiments by inducing apoptosis - programmed cell death. (naturallyhealingmd.com)
The team confirmed the role of CB1 in apoptosis, showing that tumor cells with high CB1 expression were sensitive to apoptosis when treated by a cannabinoid agonist. (naturallyhealingmd.com)
Cannabinoids are known to cross the blood-brain barrier and have been shown to kill numerous types of brain cancer cells. (rsocancerfree.com)
p38 MAPK Is Involved in CB2 Receptor-Induced Apoptosis of Human Leukaemia Cells. (rxleaf.com)
It induces apoptosis on tumor cancer cells. (healthycures.org)
Apoptosis is cellular programmed cell death (PCD) that's part of normal cells die-off and replacement from new cells. (healthycures.org)
But cancer tumor cells don't do apoptosis. (maxdiaries.com)
A study published in Nature Reviews: Cancer provides an historic and detailed explanation about how THC and natural cannabinoids counteract cancer, but preserve normal cells. (wakeup-world.com)

In a story very similar to the discovery of opiate receptors in the brain, cannabinoid receptors have been discovered along with their endogenous cannabinoids, representing the largest neurotransmitter system in the brain and immune system. (greenmedinfo.com)
It seemed likely that something similar was happening with THC and the cannabinoid receptors in the brain and the immune system. (greenmedinfo.com)

Two cannabinoid G protein-coupled receptors have been cloned thus far, CB1 receptors (Matsuda et al. (420magazine.com)

2018). Therefore, using cannabinoids for tumor reduction could potentially interfere with established breast cancer treatments. (caplancannabis.com)

Pretreatment with CBD and its analog could reduce the levels of NF-kB, suggesting that the cannabinoids were indeed acting through the NF-kB pathway. (news-medical.net)
Thus, the researchers wanted to test if the cannabinoids were reducing NF-kB due to induction of apoptosis or an independent pathway. (news-medical.net)
RNA profiling identified 2283 differentially expressed genes in F7+F3 treatment, among them genes related to the Wnt signaling pathway and apoptosis-related genes. (nih.gov)
This pathway controls the process of apoptosis, or cell death. (rxleaf.com)

For example, it was shown to activate an immune response in mice in response to LPS induced pulmonary inflammation. (royalseedsboutique.com)
Cannabinoids Activate p38 Mitogen‐Activated Protein Kinases through CB1 Receptors in Hippocampus. (rxleaf.com)

It was earlier thought that cannabinoids exert their physiologic and behavioral effects via nonspecific interaction with cell membranes. (aacrjournals.org)

In a recent study, the researchers investigate the potential effects of the cannabinoids on inflammation and the mechanisms behind it. (news-medical.net)
However, the effects of cannabinoids are not limited to the central nervous system. (news-medical.net)
Currently, use of cannabinoids is limited to improve adverse effects of chemotherapy and their palliative administration during treatment is curiously concomitant with improved prognosis and regressed progression in patients with different tumor types. (frontiersin.org)
Although anticancer effects of cannabinoids were shown as early as 1975 in Lewis lung carcinoma (ref. 1 and references therein), renewed interest was generated little after the discovery of the cannabinoid system and cloning of the specific cannabinoid receptors ( 1 ). (aacrjournals.org)
These outcomes were reversed by CB1/CB2 antagonists, suggesting that THC-mediated these effects through cannabinoid receptors. (aspetjournals.org)
Nevertheless, the study performed by Merroun and colleagues [33] suggested the lateral hypothalamus-derived orexin A as a mediator of the anorexigenic effects induced by CB1 antagonist AM251 as well [33]. (researchgate.net)
The research team also investigated the effects of cannabinoid treatments on living animal models. (medicaljane.com)
Our aim is to identify immune functions modulated by cannabinoids that could account for their anti-inflammatory effects in these animal models. (420magazine.com)
Though cannabinoids are clinically used for anti-palliative effects, recent studies open a promising possibility as anti-cancer agents. (oncotarget.com)
CB1 receptors are ubiquitously located, with their highest presence found in the central nervous system (basal ganglia, hippocampus, cerebellum and cortex) where they mediate cannabinoid psychoactive effects [ 7 - 8 ]. (oncotarget.com)
While there are no studies to date that have confirmed CBD eases the side effects of cancer or cancer therapy, the molecule is understood to have some potential in modulating the most common and debilitating symptoms 15 Although largely based on THC, there are also already some cannabinoid-based drugs on the market prescribed to help relieve symptoms caused by chemotherapy. (dsm.com)
Epigenetic effects that may induce apoptosis (Maccarrone et al. (caplancannabis.com)
Yet, it is only in the last several decades that our understanding of these effects had grown following some landmark discoveries in the field of cannabinoid research. (degruyter.com)
The current study is to reveal the regulatory effects of Rg1 on cytoskeletal and morphological lesion in oxidative stress-induced neuronal apoptosis. (ijbs.com)
Activation of the CB1 and CB2receptors by cannabinoids can elicit antitumor effects in a number of aggressive cancers. (qualifyingconditions.com)
Unveiling the angiogenic effects of cannabinoids: Enhancers or inhibitors? (cannabisclinicians.org)
https://www.cannabisclinicians.org/wp-content/uploads/2020/06/scc_logo-long-R-2-1.png 0 0 Michelle Smith https://www.cannabisclinicians.org/wp-content/uploads/2020/06/scc_logo-long-R-2-1.png Michelle Smith 2023-08-04 08:01:22 2023-08-04 08:01:22 Unveiling the angiogenic effects of cannabinoids: Enhancers or inhibitors? (cannabisclinicians.org)
Their high barrier permeability and strong apoptosis-inducing effects make cannabinoids very promising candidates for the treatment of many brain cancers. (rsocancerfree.com)
The documents went into such a memory hole that researchers in Madrid, Spain's 2000 huge breakthrough study of cannabis TCH cannabinoid effects on cancer couldn't get them for their paper. (healthycures.org)
Dr. Kirsten Mueller-Vahl of the Hanover Medical College in Germany led a team that investigated the effects of chemicals called cannabinols (a non-psychoactive cannabinoid) in 12 adult Tourette's patients. (wakeup-world.com)

For the study, the researchers used cannabinoids with 99.9% purity and which had no other cannabinoid present. (news-medical.net)
Upon further investigation, the team of Spanish researchers determined that cannabinoid-induced apoptosis occurred through activation of the CB2 receptor - one of two widely-acknowledged cannabinoid receptors. (medicaljane.com)
What's clear is that researchers have only scratched the surface of the health benefits of cannabinoids and how these ingredients might be used. (cysb22jc.top)
Researchers call cannabigerol (CBG) the "Mother of All Cannabinoids. (justkana.com)

Cannabinoids Promote Progression of HPV Positive Head and Neck Squamous Cell Carcinoma via p38 MAPK Activation. (rxleaf.com)

For example, previous studies show that cannabinoids can work as anti-inflammatory drugs, they can suppress the signaling of T cell receptors, induce apoptosis, lower the levels of pro-inflammatory cytokines, and act on macrophages. (news-medical.net)

Turning CB1 back on and then treating with a cannabinoid agonist could provide a new approach to colorectal cancer treatment or prevention. (naturallyhealingmd.com)

Scientists believe that cannabigerol is actually one of the oldest forms of cannabinoids, meaning it works in conjunction with the rest of the cannabinoids. (potmy.com)
But when the acid form of cannabigerol (CBGA) metabolizes, the molecule transforms into several completely distinct cannabinoids. (justkana.com)

however, DHCer induces autophagy and may be important in the regulation of this important cellular process. (sphingolipidclub.com)

Natural product anticancer agents enhance intracellular levels of ceramide, a sphingolipid that promotes cell apoptosis. (sphingolipidclub.com)
Research in animal models suggests the possible use of cannabinoids as anticancer drugs. (medscape.com)

Apoptosis induction was further confirmed by morphological changes, an increase in Caspase 3/7 and a decrease in the ATP levels. (biomedcentral.com)
The Rg1 treatment also abolished H 2 O 2 -induced morphological changes, including cell rounding, membrane blebbing, neurite retraction and nuclei condensation, which were generated by myosin IIA-actin interaction. (ijbs.com)

This study focused on the investigation of cannabinoid profiles and contents of 23 different hemp teas and on the individual transfer of 16 cannabinoids from hemp teas into their tea infusions. (cannabisclinicians.org)
For each hemp tea, an infusion was prepared according to a standardized protocol issued by the German Standardisation body DIN and transfer rates per cannabinoid were estimated by com- paring the contents in the dry material with the concentrations in the aqueous infusion. (cannabisclinicians.org)
Hemp farmers have also started harvesting the plants earlier before the CBGA starts to convert into other cannabinoids. (justkana.com)

They then proceeded to treat the tumors with one of three options - tetrahyrdrocannabinol (THC) , JWH (a synthetic cannabinoid), or a placebo for comparison. (medicaljane.com)

The administration of cannabinoids seemed to induce cancer cell apoptosis (programmed cell death). (medicaljane.com)
There are a number of pre-clinical in-vitro and in-vivo studies that suggest cannabinoids - including CBD and THC - have anti-cancer activity in a wide variety of cancer types, including a role in cancer cell death and blocking cancer cell growth. (dsm.com)
It even shuts down the function of apoptosis (cell death). (honeycolony.com)
This is called apoptosis, or programmed cell death. (wakeup-world.com)

The findings of a new study "indicate that CBD might be beneficial in alleviating UVB-induced skin damage in humans. (themarijuanaherald.com)

New preclinical research shows that cannabinoid cell surface receptor CB1 plays a tumor-suppressing role in human colorectal cancer, scientists report in the Aug. 1 edition of the journal Cancer Research. (naturallyhealingmd.com)
Overexpression of survivin is associated with poor outcome and reduced apoptosis in colorectal cancer patients. (naturallyhealingmd.com)
Just increasing the levels of cannabinoids to treat colorectal cancer won't work if the CB1 receptor is not present," DuBois said. (naturallyhealingmd.com)
This suggests that treating first with a demethylating agent, such as decitabine, to reactivate CB1 in the tumor and following up with a cannabinoid might be an effective attack on colorectal cancer. (naturallyhealingmd.com)

In addition to inducing apoptosis when binding to a cancer cell, THC may also help relieve pain. (projectcbd.org)

We chose to focus on MS because it is characterized by relapsing-remitting and chronic inflammation in the central nervous system (CNS), and cannabinoids have been shown to affect its pathogenesis. (420magazine.com)
Currently, a main focus of clinical research is cannabinoids' efficacy in chronic pain and neurological disorders. (cysb22jc.top)
Its ability to provide relief of chronic pain, to induce an increase in appetite, to alleviate nausea, and to ease anxiety are only some of the common uses for it. (medscape.com)

This initial discovery has allowed the synthesis of structurally modified molecules that have been used to study structure-activity relationships and reveal tight structural and steric selectivity in the biological actions of cannabinoids. (degruyter.com)
CB1 is well-established for relieving pain and nausea, elevating mood and stimulating appetite by serving as a docking station for the cannabinoid group of signaling molecules. (naturallyhealingmd.com)

Growing evidence suggests that a major physiological function of the cannabinoid signaling system is to modulate neuroinflammation. (420magazine.com)
This study provides strong evidence for the use of cannabinoid based therapies for the management of Breast Cancer. (morethanshipping.com)
Evidence shows that smoking of cannabis preparations caused cancer of the respiratory and oral tracts or, at least, potentiated tobacco smoke-induced damages [ 3 ]. (oncotarget.com)
There is evidence of THC-induced dysfunction in both splenic lymphocytes and APCs. (royalseedsboutique.com)
It also included blood samples from five patients with HPV-related throat cancer - whose plasma showed evidence of cannabinoids in their system. (rxleaf.com)

Thymic atrophy was the result of direct action of THC and not based on maternal factors inasmuch as THC was able to induce T cell apoptosis in vitro in fetal thymic organ cultures. (aspetjournals.org)

It suggests that cannabinoids could help treat pancreatic adenocarcinoma - one of the most aggressive forms of cancer. (medicaljane.com)

Anatomy23

Organisms11

Diseases15

Chemicals and Drugs135

Analytical, Diagnostic and Therapeutic Techniques and Equipment23

Psychiatry and Psychology7

Phenomena and Processes44

Disciplines and Occupations2

Anthropology, Education, Sociology and Social Phenomena3

Information Science1

Health Care5

Cannabidiol11

Inhibit11

Proliferation5

Compounds18

Potential of cannabinoids2

Endocannabinoids6

Tumor growth3

Lead to apoptosis3

Role of cannabinoid receptors2

Uses of cannabis and cannabinoids1

Endocannabinoid2

Pathways3

Called cannabinoid receptors1

Agonists3

Ligands2

Anandamide4

Therapeutic4

Tetrahydrocannabinol3

Types of cannabinoid1

Marijuana5

Cells18

Receptors in the brain2

Protein-coupled receptors1

20181

Pathway4

Activate2

Exert1

Effects20

Researchers4

Progression1

Anti-Inflammatory1

Agonist1

Cannabigerol2

Autophagy1

Anticancer2

Morphological changes2

Hemp3

Synthetic1

Cell death4

Findings1

Colorectal cancer4

Cancer cell1

Chronic3

Molecules2

Evidence5

Vitro1

Suggests1