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  • anandamide
  • At present, there are five recognized cannabinoids produced endogenously throughout the body: Arachidonoylethanolamine (anandamide), 2-arachidonoyl glycerol (2-AG), 2-arachidonyl glyceryl ether (noladin ether), virodhamine, as well as the recently discovered N-arachidonoyl-dopamine (NADA). (wikipedia.org)
  • Synthetic Cannabinoid
  • Zynerba Pharmaceuticals Inc (NASDAQ: ZYNE), which specializes in transdermal synthetic cannabinoid treatments, has a 25-percent probability for success in its treatment of adult epilepsy, an analyst said Tuesday. (benzinga.com)
  • Dexanabinol (HU-211), a synthetic cannabinoid, is currently being assessed in clinical trials for traumatic brain injury and stroke. (springer.com)
  • NMS Labs has responded to the recent explosive growth in popularity of synthetic cannabinoid agonists in so-called "herbal blends" by developing new tests for the active chemicals in botanical material, and most recently for the parent drugs and their metabolites in blood and urine. (slideshare.net)
  • anti-inflammatory properties
  • The researchers also uncovered studies that showed that THC reduced inflammation in mice, which indicates that the skin health benefits of cannabinoids might be down to their anti-inflammatory properties. (medicalnewstoday.com)
  • Cannabinoids contain anti-inflammatory properties that could make them useful in the treatment of a wide range of skin diseases, according to researchers at the University of Colorado Anschutz Medical Campus. (uspharmacist.com)
  • Effects
  • Very little is known about the physiological and biochemical mechanisms involved in the effects of Δ9-tetrahydrocannabinol and the cannabinoids in feeding and appetite. (google.com)
  • Cannabinoids have many side effects and adverse drug reactions. (springer.com)
  • Based on the cannabinoid distribution and activity mechanism as well as proteins involved in their biotransformation, a set of candidate genes can be chosen which variants may determine the therapeutic effect and also the occurrence of possible side effects and adverse reactions. (springer.com)
  • An important step forward in understanding the biological effects of cannabinoids was made in 1988 when Howlett and colleagues ( 11 ) used a high-affinity radioactive cannabinoid ligand, [ 3 H]CP-55,940, to demonstrate the existence of a specific cannabinoid binding site in cell membranes of rat brain. (pnas.org)
  • The discovery of this receptor helped provide a molecular explanation for the established effects of cannabinoids on the immune system. (wikipedia.org)
  • The meta-analysis, led by the University of Bristol and published in the Journal of the American Medical Association, analysed the results of 79 different randomised-controlled studies involving more than 6,400 patients to investigate the benefits and side effects of medical cannabinoids. (bristol.ac.uk)
  • The team did not find any clear evidence on the benefits or adverse effects from taking particular type of cannabinoids or its mode of administration. (bristol.ac.uk)
  • And, over recent years, the potential anti-cancer effects of cannabinoids have come into focus . (medicalnewstoday.com)
  • The drugs were developed in the 1980's and 1990's as potential cannabinoid agonists that might possess some of the advantageous effects of cannabis, appetite stimulation, and anti- nausea properties, blood pressure, and much flaunted as adjuncts in cancer pain therapy, without the euphoric intoxicating effects for which the drug was popular recreationally. (slideshare.net)
  • Cannabinoids, the active components of the hemp plant Cannabis sativa, along with their endogenous counterparts and synthetic derivatives, have elicited anti-cancer effects in many different in vitro and in vivo models of cancer. (unboundmedicine.com)
  • And Δ9-tetrahydrocannabivarin (THCV), a naturally occurring cannabinoid, modulate the effects of THC via direct blockade of cannabinoid CB1 receptors, thus behaving like first-generation CB1 receptor inverse agonists, such as rimonabant. (wikipedia.org)
  • CB1 receptors are expressed most densely in the central nervous system and are largely responsible for mediating the effects of cannabinoid binding in the brain. (wikipedia.org)
  • The discovery of this receptor helped provide a molecular explanation for the established effects of cannabinoids on the immune system. (wikipedia.org)
  • The psychoactive effects of THC are primarily mediated by the activation of cannabinoid receptors, which result in a decrease in the concentration of the second messenger molecule cAMP through inhibition of adenylate cyclase. (wikipedia.org)
  • Effects of synthetic cannabinoids on electroencephalogram power spectra in rats. (wikipedia.org)
  • clinical trials
  • Indeed, in clinical trials of postoperative and cancer pain and pain associated with spinal cord injury, cannabinoids have proven more effective than placebo but may be less effective than existing therapies. (springer.com)
  • Although three clinical trials studied cannabinoids for the treatment of Parkinson's Disease , these studies "did not provide a clear answer whether cannabinoids modify the progression or the outcome of the disease," wrote Bilkei-Gorzo. (time.com)
  • Parkinson's Disease
  • Evidence suggests that cannabinoids may prove useful in Parkinson's disease by inhibiting the excitotoxic neurotransmitter glutamate and counteracting oxidative damage to dopaminergic neurons. (springer.com)
  • Humans
  • Humans have endogenous (naturally occuring) cannabinoid receptors throughout our bodies and brains, which were discovered after those in the plant. (erowid.org)
  • The same effect is observed in animals and in humans with the psychotropic plant cannabinoid Δ9-tetrahydrocannabinol, which is an approved appetite-enhancing drug. (google.com)
  • CRIS aims to obtain scientific evidence about the application of Cannabinoid and Medical cannabis to humans and animals, for health, disease and disorders. (wikipedia.org)
  • chemical
  • To date, there have been more than 100 cannabinoids identified, all with different properties and chemical profiles. (medicalnewstoday.com)
  • The Cannabinoids: Chemical, Pharmacologic, and Therapeutic Aspects provides a comprehensive discussion of the various aspects of cannabis and its constituents. (elsevier.com)
  • A large number of cannabinoids have been grouped into classes based on similarities in their chemical structure, and these classes have been widely adopted across a variety of jurisdictions. (wikipedia.org)
  • example definition from Kentucky, which is substantially derived from the 2009 ACMD advice on synthetic cannabinoids in the UK) This causes a substance such as MAM-2201 to be controlled as a Schedule 1 illegal drug, even though "MAM-2201" or its corresponding chemical name are not specifically listed in the statute. (wikipedia.org)
  • With chemical name, (−)-trans-Δ⁹-tetrahydrocannabinol, the term THC also refers to cannabinoid isomers. (wikipedia.org)
  • 2017
  • The Cannabinoid Research Initiative of Saskatchewan (CRIS) was founded in 2017 as interdisciplinary research team of clinician researchers (medical and veterinary), basic scientists, and social scientists. (wikipedia.org)
  • multiple sclerosis
  • In a trial of a sublingual spray containing delta-9-THC alone or combined with cannabinol, Rog and colleagues reported a 41% reduction in pain, compared with a 22% reduction with placebo.18 Literature on cannabinoids for pain conditions other than multiple sclerosis is limited, although three recent randomized placebo-controlled trials of smoked cannabis found significant reductions in neuropathic pain. (google.com)
  • They found there was only moderate-quality evidence to suggest cannabinoids may alleviate chronic neuropathic or cancer pain and muscle contractions or involuntary movements due to multiple sclerosis. (bristol.ac.uk)
  • metabolism
  • The patient's response to cannabinoid treatment may have a genetic background, which depends on genes polymorphism involved in the action, metabolism, and the transport of these substances in the organism. (springer.com)
  • mice
  • Other studies covered in the review showed that mice bred to lack the cannabinoid receptors have better memories early in life but have more rapid cognitive decline as they age, including inflammation in the hippocampus, a key region for memory. (time.com)
  • This finding suggests that, at some point during aging, cannabinoid activity helps maintain normal cognitive functions in mice," says Daniele Piomelli, professor of neurobiology, anatomy and biological chemistry at the University of California - Irvine, who was not associated with the study. (time.com)
  • inhibition
  • Signalling is mostly inhibitory and suggests a role for cannabinoids as therapeutic agents in CNS disease where inhibition of neurotransmitter release would be beneficial. (springer.com)
  • Cabral, GA, Harmon, KN, Carlisle, SJ 2001 Cannabinoid-mediated inhibition of inducible nitric oxide production by rat microglial cells: Evidence for CB 1 receptor participation Adv. Exp. (springer.com)
  • mechanisms
  • This review will summarize the anti-cancer properties of the cannabinoids, discuss their potential mechanisms of action, as well as explore controversies surrounding the results. (unboundmedicine.com)