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  • genomic
  • Finally, using allele-specific transcription data, we present evidence for a transcriptional buffering system that increases the expression of maternal alleles and represses paternal alleles in response to excess paternal genomic dosage. (plantcell.org)
  • The presence of few gene hybridization abnormalities, corroborated by gene dosage measurements, were hypothetically due to the segregation of hemizygous alleles and minor genomic rearrangements occurring during the haploidization procedure. (biomedcentral.com)
  • The candidate genomes were evaluated using genomic or EST-derived SSR markers and microarray technology. (biomedcentral.com)
  • We have performed a combined comparative genomic hybridization and transcriptomic analyses of 10 adult-type GCTs to obtain a picture of the genomic landscape of this cancer type and to identify new candidate co-driver genes. (biomedcentral.com)
  • This combined analysis is the first attempt to obtain a "bird's eye" view of the genomic landscape of this cancer type and to identify new candidate (co-)driver genes (termed henceforth driver genes for simplicity). (biomedcentral.com)
  • We are an interdisciplinary team of physicists, bioinformaticians and experimental biologists, and we focus on data collection (behavior, 3D imaging, genomic data) of many variables of the system (longitudinal behavioral analysis, population based analysis in neuronal networks, gene expression patterns). (crg.eu)
  • We take advantage of computer modeling and bioinformatics analysis (gene networks, neuronal network modeling, etc.) to tackling classical unresolved questions in the field, such as: (a) pathological disturbances of structural optimality in single cell and neuronal networks, (b) genomic dependence of cognitive disturbances, (c) identification of predictive non-invasive biomarkers, (d) discovery of pro-cognitive therapies. (crg.eu)
  • locus
  • To convince ourselves that the observation could indeed be due to incomplete dosage compensation in the ITM2A locus, we gathered further pieces of evidence. (genomesunzipped.org)
  • A statistical comparison showed that, given the effect estimates and standard errors in each sex, escape from inactivation is a much more likely model than full dosage compensation in the ITM2A locus, but not in the other two associated loci. (genomesunzipped.org)
  • We define a 1007 bp evolutionarily conserved region (ECR) 5′ to the Hand1 locus sufficient to drive reporter gene expression throughout the developing and postnatal sympathetic ganglia (SG). (jneurosci.org)
  • 5, 6 Using a cell line in which a specific gene locus (DNA), its mRNA product, and the final protein product can be fluorescently labeled and visualized in vivo , it is possible to detect the actual transcription of mRNAs on the gene of interest. (jove.com)
  • The tissues and DNA samples from the three candidate plants have been analyzed and characterized using various technologies and methods by laboratories in several institutions worldwide to assure that they are free of large deletions or other defects, as well as to confirm their homozygosity (mono-allelic at any locus analyzed). (biomedcentral.com)
  • overexpression
  • Validation of the circular CV for mouse transgenesisAs proof-of-principle for the use of the circular CV for the overexpression of XLID- (candidate-) genes in mice we modified BACs RP11-119A22 and RP11-51C14 encoding MECP2 and SOX3, respectively, and inserted them into the CV via Cre-loxP recombination. (kuleuven.be)
  • mutations
  • For this, three model systems are used within the lab: primary hippocampal neurons, Drosophila melanogaster and the mouse.Whereas early-on it was generally accepted that most genetic disorders were caused by gene deletions or loss-of function mutations, recently it has become clear that duplications can underlie (severe) genetic diseases as well. (kuleuven.be)
  • Behavioral screening methods allow us to determine visual responsiveness levels resulting from gene mutations or drug treatments, and electrophysiology in individual flies identifies brain processes affected by our manipulations. (edu.au)
  • polymerase
  • We previously showed that loss of the RNA polymerase IV gene NUCLEAR RNA POLYMERASE D1 (NRPD1) in tetraploid fathers represses seed abortion in paternal excess crosses. (plantcell.org)
  • More recently a few studies have used microarray based technology to identify gene signatures predictive of radiation response [ 12 - 14 ] however, none of them had validated their genes using further techniques such as Real time Polymerase Chain Reaction (PCR). (biomedcentral.com)
  • deletions
  • On average, at least one additional gene and two additional CpG islands were disrupted by rare deletions in cases compared to controls. (cancerindex.org)
  • cervical
  • Detection of hypermethylated genes as markers for cervical screening in women living with HIV. (nih.gov)
  • Identification and Validation of a 3-Gene Methylation Classifier for HPV-Based Cervical Screening on Self-Samples. (nih.gov)
  • We have identified a 7 gene signature which could help identify patients with cervical cancer who can be treated with radiotherapy alone. (biomedcentral.com)
  • determination
  • Here we show that a SNP, 538G right arrow A (rs17822931), in the ABCC11 gene is responsible for determination of earwax type. (blogspot.ca)
  • elongation
  • 4 Herein we describe how to perform analysis of Pol II elongation kinetics on a specific gene in living cells. (jove.com)
  • promoter
  • We initiated study of the 5'-flanking region of the rat Class III neuron-specific beta-tubulin gene (betaIII-tubulin) because this gene is expressed at the time of terminal mitosis only in neurons and thus its promoter should be an excellent tool for studying neuron-specific gene expression during the transition from proliferative progenitor cell to early neuronal differentiation. (jove.com)
  • We identified the minimal promoter region needed to drive expression of the betaIII-tubulin gene. (jove.com)
  • cell
  • Cyclin D1-negative mantle cell lymphoma: a clinicopathologic study based on gene expression profiling. (springer.com)
  • The decrease in granule cell proliferation demonstrated in newborn Ts1Cje cerebellum was correlated with a major gene dosage effect on the transcriptome in dissected cerebellar external granule cell layer. (pubmedcentralcanada.ca)
  • tissues
  • The impact of this gene dosage effect on the whole transcriptome is still debated and longitudinal studies assessing the variability among samples, tissues and developmental stages are needed. (pubmedcentralcanada.ca)
  • likely
  • Using a seven gene based scoring system, it was possible to distinguish between the tumours which were likely to respond to the radiotherapy and those likely to fail. (biomedcentral.com)
  • Additionally, the X-linked, candidate dosage-sensitive sex-reversal gene, Dax-1, antagonizes synergy between SF-1 and WT1, most likely through a direct interaction with SF-1. (uniprot.org)
  • thus
  • Interploidy seed abortion is thus unlikely to be caused by transposable elements or imprinted gene misregulation, and its repression by the loss of paternal RdDM is associated with only modest gene expression changes. (plantcell.org)
  • level
  • We approach this problem by targeting candidate molecular systems at the level of molecular lesions and pharmacology. (edu.au)
  • Level 3 of Exp-Gene" files from COAD Data Matrix Datasets were downloaded and used to extract mRNA expression for RFC4 . (biomedcentral.com)