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FungemiaCandidaCandidiasisCandida albicansAntifungal AgentsFluconazoleCandida glabrataDrug Resistance, FungalCandida tropicalisEchinocandinsAmphotericin BMycosesMycologyMycological Typing TechniquesTrichosporonMicrobial Sensitivity TestsTriazolesFungiLipopeptidesCandidiasis, OralItraconazoleCandidiasis, VulvovaginalCryptococcusBloodSterol 14-DemethylaseFlucytosineDNA, FungalCulture MediaOsmoregulationChromogenic CompoundsCandidemiaPeptides, CyclicMicrobiological TechniquesYeastsAgarKetoconazolePyrimidinesAzolesSpecies SpecificityCryptococcus neoformansCross InfectionDermatomycosesNeutropeniaRhodotorulaAspergillusEvaluation Studies as TopicDrug Resistance, MicrobialCatheterization, Central VenousExophialaPeptonesAspergillosisImmunocompromised HostDrug Resistance, Multiple, FungalOpportunistic InfectionsBacteremiaFungal ProteinsZygomycosisAntigens, FungalErgosterolDNA, Ribosomal SpacerCentrifugationHyphaeQuality ControlMouthRandom Amplified Polymorphic DNA TechniqueSensitivity and SpecificityYeast, DriedCryptococcosisCytochrome c GroupSepsisPolymerase Chain ReactionHematologic NeoplasmsHospitals, UniversityTrichosporonosisAIDS-Related Opportunistic InfectionsBacteriaFatal OutcomeReproducibility of ResultsSugar AlcoholsPichiaColony Count, MicrobialAerobiosisEye Infections, Fungal
GlabrataTropicalisParapsilosisInfectionsVirulence factorsCandidemiaStrainsPathogenicityIsolatesOpportunisticNosocomialYeastCandidiasisFungusInfectionFungiSusceptibilityBiofilmsPathogenicPathogensCommensal organismsAurisEchinocandinsSkin and mucousAlbicans speciesPatientsIncidenceFacilitateFrequently isolatedMortalityTemperature
Glabrata15
  • Other Candida species that also fit this profile are C. parapsilosis, C. glabrata, C. tropicalis, C. guillermondii and C. rugosa. (wikipedia.org)
  • Candida albicans, C. tropicalis, C. glabrata, C. parapsilosis and C. guilhermondii were seeded into antibacterial (cefepime, meropenem, vancomycin, and piperacillin- tazobactam) gradient plates produced in Mueller-Hinton Agar. (bvsalud.org)
  • however, Candida glabrata and Candida parapsilosis tend to be the most common isolates after Candida albicans in invasive candidiasis. (medscape.com)
  • C glabrata and C krusei have been identified as common causes of candidemia in patients with hematologic malignancies. (medscape.com)
  • however, C. glabrata (formerly Torulopsis glabrata ) and other non-albicans species are increasingly involved in fungemia, urinary tract infections, and, occasionally, other focal disease. (msdmanuals.com)
  • The oral Candida strains were isolated from the HIV patients and included species of C. albicans , C. glabrata , C. tropicalis , C. parapsilosis , C. krusei , C. norvegensis , and C. dubliniensis . (biomedcentral.com)
  • Candida glabrata is a yeast of increasing medical relevance, particularly in critically ill patients. (encyclopedia.pub)
  • Candida glabrata is an asexual, haploid yeast of the clade Nakaseomyces. (encyclopedia.pub)
  • Candida glabrata is a successful pathogen colonising epithelial surfaces (mouth, gastrointestinal tract, vagina, skin, and present in stool) as healthy microbial flora with no age specificity [ 10 ] . (encyclopedia.pub)
  • Increasing incidence of C. glabrata among Candida species as a cause of BSI in U.S. ICUs between 1989 and 1999 in a survey showed that C. glabrata ranked second to C. albicans accounting for 20% to 24% of all Candida BSIs [ 12 ] . (encyclopedia.pub)
  • However, the rate of non- albicans Candida species such as C. tropicalis, C. krusei, C. parapsilosis, C. glabrata which are more resistant to antifungal therapy, has been increasing rapidly in recent studies (1, 2, 4, 5). (idcmjournal.org)
  • Of the total 70 clinical Candida isolates, the most predominant organism isolated was found to be C. tropicalis 27 (38.57%) which is succeeded by 19 (27.14%) C. albicans , 13 (18.57%) C. parapsilosis , 6 (8.57%) C. glabrata, and 5 (7.14%) C. krusei respectively. (microbiologyjournal.org)
  • Filamentous forms may contribute to colonization and infection, although species that do not form filaments, such as Candida glabrata, colonize and cause invasive disease in VLBW infants. (medscape.com)
  • Candida albicans accounts for majority of the cases followed by some non albicans species as C. krusei and C. glabrata . (wikidoc.org)
  • Candida glabrata is the most common isolated pathogen in this group affecting 10 to 20% of women and is associated with recurrent Candida vulvovaginitis . (wikidoc.org)
Tropicalis4
Parapsilosis2
  • Several institutions reported a rise not only in fungemia incidence but also in the number of cases caused by Candida auris or fluconazole-resistant C. parapsilosis during the COVID-19 pandemic. (bvsalud.org)
  • however, unlike in North America, C parapsilosis is the second most common Candida species in many Latin American countries. (medscape.com)
Infections21
  • Candida is the third or fourth most common cause of nosocomial bloodstream infection in the United States, accounting for 8%-10% of all bloodstream infections. (medscape.com)
  • [ 1 ] There is an increasing shift toward infections caused by non- albicans Candida species, which now cause 40%-60% of reported cases. (medscape.com)
  • In Europe, Candida species are the sixth to tenth most common cause of bloodstream infections. (medscape.com)
  • Candida species account for about 80% of major systemic fungal infections and are the most common cause of fungal infections in immunocompromised patients. (msdmanuals.com)
  • Because of the inherent immunosuppression of cancer patients opportunistic infections by Candida spp, occur frequently. (biomedcentral.com)
  • Cancer patients with metastasis have a high probability of mucocutaneous and bloodstream infections by fungi, including Candida species. (biomedcentral.com)
  • Echinocandins are the first-line therapy for treatment of invasive Candida infections, but the mortality rate remains high, calling for novel strategies. (dovepress.com)
  • Single caspofungin doses used in mice in this study are attainable in humans as well, suggesting a potential place of this dosing strategy not only in prevention but also in curative treatment of evolved invasive Candida infections. (dovepress.com)
  • The frequency of invasive Candida infections has increased worldwide in the last decades. (dovepress.com)
  • 1 - 5 The mortality rate of invasive Candida infections is around 40%, but in intensive care units, 50-75% mortality rates were observed among critically ill patients even in case of C. albicans despite the introduction of echinocandins into the antifungal armamentarium. (dovepress.com)
  • 6 - 8 This antifungal class shows excellent in vitro and in vivo activity against Candida species and has quickly become the first therapeutic choice for the treatment of candidemia and other forms of invasive Candida infections. (dovepress.com)
  • Invasive Candida infections in a pediatric intensive care unit in Turkey: evaluation of an 11-year period. (pidjournal.com)
  • Ten-year review of invasive Candida infections in a tertiary care center in Saudi Arabia. (pidjournal.com)
  • Candida can cause mucocutaneous and/or systemic infections in hospitalized and immunosuppressed patients. (biomedcentral.com)
  • Among Candida species, C. albicans is the most commonly isolated and responsible for the majority of superficial and systemic infections. (biomedcentral.com)
  • Candida species commonly cause invasive nosocomial infections in immunocompromised patients [ 5 ] . (encyclopedia.pub)
  • We aimed to detect the risk factors for invasive candida infections by evaluating the fungal strains cultivated from samples taken in a medical intensive care unit (ICU). (idcmjournal.org)
  • Moreover, laboratory misidentification and multi-drug-resistant profiles, rarely observed for other non-albicans Candida species, result in difficult eradication and frequent therapeutic failures of C. auris infections. (biomedcentral.com)
  • Infections caused by Candida spp. (biomedcentral.com)
  • Candida species causing bloodstream infections (BSIs) are also called candidemia which exists mostly as a pervasive type of invasive candidiasis. (microbiologyjournal.org)
  • Candida Albicans is responsible for the majority of Candida infections. (wikidoc.org)
Virulence factors3
  • The infection thrives best in the presence of Candida species-specific virulence factors such as the presence of hyphae for invasion into host tissues [ 19 ] . (encyclopedia.pub)
  • All of these multiple virulence factors could raise BSIs of Candida species by escape mechanism which is part of the defence system in order to impair the host tissue. (microbiologyjournal.org)
  • 12 The manifestation of virulence factors of Candida species can be differentiated based on species, type of infection, geographical region, host reaction and stage, and the site of infection. (microbiologyjournal.org)
Candidemia4
Strains4
  • We assessed the pathogenicity of the strains by infecting G. mellonella animals with Candida strains and observing survival. (biomedcentral.com)
  • Among fungal growths in samples from critically ill patients, the incidence of non- albicans Candida strains was gradually increasing. (idcmjournal.org)
  • The incidence of non- albicans strains among candida growths has been increasing over the years. (idcmjournal.org)
  • Due to these variations, it is important to differentiate these strains in clinical situations like Candida endophthalmitis due to potential differences in presentation, treatment, and clinical outcomes. (springeropen.com)
Pathogenicity4
  • The pathogenicity of Candida spp. (biomedcentral.com)
  • Candida albicans - biology, molecular characterization, pathogenicity, and advances in diagnosis and control - an update. (pidjournal.com)
  • Importantly, for C. albicans the pathogenicity of oral Candida isolates was similar to systemic Candida isolates, suggesting that Candida isolates have similar biofilm-forming ability and virulence regardless of the infection site from which it was isolated. (biomedcentral.com)
  • Many available factors facilitate the pathogenicity of Candida species. (encyclopedia.pub)
Isolates7
  • OBJECTIVES: Antifungal susceptibility testing is mostly conducted on blood-cultured Candida spp isolates. (bvsalud.org)
  • DISCUSSION: Testing sequential Candida isolates from intra-abdominal samples is required to detect antifungal resistance, particularly to echinocandins, in patients whose incident isolates turned out to be susceptible. (bvsalud.org)
  • Since the pandemic broke out in early 2020, we studied its impact on fungemia incidence, species epidemiology, potential patient-to-patient transmission, and antifungal resistance in 166 incident yeast isolates collected from January 2020 to December 2022. (bvsalud.org)
  • therefore, Candida accounts for proportionately more fungal corneal isolates at temperate latitudes. (medscape.com)
  • Seventy clinically known Candida isolates are isolated in positively flagged blood samples from BacT/ALERT 3D from various wards. (microbiologyjournal.org)
  • Among the70 Candida isolates, 49 (70%) showed hemolysin production, 43 (61.42%) isolates demonstrated phospholipase activity, 34 (48.57%) showed coagulase activity and 55 (78.57%) isolates showed biofilm production by crystal violet assay. (microbiologyjournal.org)
  • A high level of Fluconazole resistance has been observed in 23 (32.85%) Candida isolates in comparison with other antimicrobials utilized in this study. (microbiologyjournal.org)
Opportunistic1
  • The balance between the virulence of the fungus and the host immune defense is responsible avoiding opportunistic infection of candida. (wikidoc.org)
Nosocomial2
  • Candida krusei is an emerging fungal nosocomial pathogen primarily found in the immunocompromised and those with hematological malignancies. (wikipedia.org)
  • Nosocomial transmission of Candida pelliculosa fungemia in a pediatric intensive care unit and review of the literature. (pidjournal.com)
Yeast2
  • Candida is a unicellular yeast whose cells reproduce by budding. (medscape.com)
  • Candida has the ability to grow either as pseudohyphae (elongated ellipsoid form) or in a yeast form (rounded to oval budding form. (wikidoc.org)
Candidiasis6
Fungus5
Infection6
  • The range of infection with Candida species varies from a benign local mucosal membrane infection to disseminated disease. (medscape.com)
  • Candida bloodstream infection: changing pattern of occurrence and antifungal susceptibility over 10 Years in a tertiary care Saudi hospital. (pidjournal.com)
  • However, since the procedure is invasive, it is suggested that the Candida score may also be used to estimate the presence of infection (2,4-6). (idcmjournal.org)
  • Adherence and the slow-growing nature of Candida facilitate its ability to colonize and disseminate into the bloodstream and body tissues before clinical signs and symptoms of infection become apparent. (medscape.com)
  • It is usually a superficial infection of the moist areas of the body and is generally caused by CANDIDA ALBICANS. (lookformedical.com)
  • These cases are usually associated with deficient immunity C. albicans is the main species causing infection in humans more than any other candida species. (wikidoc.org)
Fungi2
  • This takes place with two fungi: C. krusei and Geotrichum. (wikipedia.org)
  • Candida species are the most common fungi in intensive care units (ICU) and mostly C. albicans (1-3). (idcmjournal.org)
Susceptibility2
  • Each Candida species holds unique characteristics comparative to invasive potential, virulence, and antifungal susceptibility pattern [ 1 ] . (encyclopedia.pub)
  • Further investigations revealed that 2 genetic mutations in genes responsible for MBL and IL4 production increase the host susceptibility of getting recurrent candida vulvovaginitis . (wikidoc.org)
Biofilms1
  • A major virulence factor of Candida is its ability to adapt to a variety of different habitats and the consequent formation of surface-attached microbial communities known as biofilms [ 5 ]. (biomedcentral.com)
Pathogenic2
Pathogens1
Commensal organisms1
  • Candida species are commensal organisms that colonize the skin and mucosal surfaces and adhere to catheter surfaces. (medscape.com)
Auris1
  • For the purpose of this review, we performed a systematic review of the literature using "Candida" AND "auris" as keywords. (biomedcentral.com)
Echinocandins2
Skin and mucous1
  • Candida is a normal commensal of the skin and mucous membranes. (wikidoc.org)
Albicans species1
Patients4
  • This study aimed to identify Candida species in the oral mucosa of 59 patients with orogastric cancer (OGC) and to analyze the immunological phenotype of these patients. (biomedcentral.com)
  • Among bone marrow transplant patients, C. krusei has also been noted to increase in frequency [ 2444 ]. (drfungus.org)
  • Candida species also pose a significant threat to patients in the intensive care unit (ICU) with consequential mortality outcomes. (encyclopedia.pub)
  • La réanimation agressive, la prise en charge nutritionnelle, l'excision chirur- gicale complète des plaies infectées, la fermeture rapide des plaies, les greffes et la mise au point d'une chimiothérapie locale et systémique efficace ont permis d'améliorer grandement le taux de morbidité et de mortalité chez les patients brûlés. (who.int)
Incidence1
  • Fungemia incidence increased during the COVID-19 pandemic in our hospital, however, clonal spreading was not uncontrolled. (bvsalud.org)
Facilitate1
Frequently isolated1
  • Although the proportion of non- albicans Candida species increased significantly, C. albicans is still the most frequently isolated Candida species from normally sterile body sites. (dovepress.com)
Mortality1
Temperature1
  • citation needed] C. krusei grows at a maximum temperature of 43-45 °C. Although most of the medically important Candida spp. (wikipedia.org)