• C. albicans infections can be provoked by such factors as a compromised immune system (whether from illness or stress), dietary changes, medical treatments or even alterations in hygienic routines that disrupt the normal balance of microorganisms. (giantmicrobes.com)
  • However, given that the vast majority of Candida infections occur at mucosal surfaces, recent interest has turned towards investigating the interactions between Candida and epithelial cells (ECs) and how this might elicit protective immunity. (hindawi.com)
  • Infections due to Candida albicans are frequent and of clinical importance. (biomedsearch.com)
  • Especially at a time of increasing organ transplantations, HIV infections, and resistance to antimicrobial agents a profound knowledge of the interaction between C. albicans and host tissue is mandatory. (biomedsearch.com)
  • In this Chapter, we review our current knowledge of the C. albicans diploid genome and its variability, the genetic structure of the C. albicans population and the mechanisms that are involved in C. albicans genome dynamics, with a focus on the parasexual cycle and loss-of-heterozygosity events. (springer.com)
  • We further explore the impact of genetic diversity and genome dynamics on C. albicans phenotypic diversity. (springer.com)
  • Research in the Fungal Biology and Pathogenicty Unit on the topic of genetic diversity and genome dynamics in C. albicans has been funded by Institut Pasteur and Institut National de la Recherche Agronomique. (springer.com)
  • Anderson JB, Wickens C, Khan M, Cowen LE, Federspiel N, Jones T, Kohn LM (2001) Infrequent genetic exchange and recombination in the mitochondrial genome of Candida albicans . (springer.com)
  • Genetic manipulation of Candida albicans is constrained by its diploid genome and asexual life cycle. (genetics.org)
  • The genome of C. albicans is almost 16Mb for the haploid size (28Mb for the diploid stage) and consists out of 8 sets of chromosome pairs called chr1A, chr2A, chr3A, chr4A, chr5A, chr6A, chr7A and chrRA. (wikipedia.org)
  • Next to this ORFeome there is also the availability of a GRACE (gene replacement and conditional expression) library to study essential genes in the genome of C. albicans. (wikipedia.org)
  • One of the most important features of the C. albicans genome is the high heterozygosity. (wikipedia.org)
  • These mechanisms are further being explored with the availability of the complete analysis of the C. albicans genome. (wikipedia.org)
  • The fungistatic effect is not attributable to antimetabolic action and is not caused by lysozyme or tears, neither of which inhibit growth and viability of Candida albicans. (sciencemag.org)
  • Finally, we discuss how our current knowledge of C. albicans genetic diversity could be leveraged in the future in order to get insights in the mechanisms underlying important biological attributes that are subject to variations across C. albicans isolates. (springer.com)
  • Here, we review current knowledge of the interactions between C. albicans and epithelial surfaces and how this may shape our understanding of microbial-mucosal interactions. (hindawi.com)
  • Blignaut E, Molepo J, Pujol C, Soll DR, Pfaller MA (2005) Clade-related amphotericin B resistance among South African Candida albicans isolates. (springer.com)
  • We offer Candida Albicans Antibodies for use in common research applications: ELISA, Immunocytochemistry/Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Frozen, Western Blot. (novusbio.com)