2023NSCLCEGFRMetastasisTumorTumorsClinicalCarcinomaHistologicallyDIAGNOSISColorectal cancerNoduleMucinous adenocarcinomasIdiopathicEpithelialMutationsNodulesChronicAlveolar microlithiasisPathologyAbstractIncidenceDivision of PulmonaryHistologicLung cancer etiologyPrimary pulmonaryEpidermal growth fPrognosticChemotherapyProgressionRisk of lung cancerDiffuseOvarian cancerMetastasesMolecularObstructiveOncologySurvivalDiseaseLesionsPrognosisPancreatic cancerRadiographsMonoclonalPathologistGastric CancerMortalityArterialDiseasesInvestigationPathways
20238
- Investigators have discovered that women with certain reproductive factors may have an elevated risk of developing lung cancer, according to recent findings presented by Zhang et al at the International Association for the Study of Lung Cancer (IASLC) 2023 World Conference on Lung Cancer (Abstract. (ascopost.com)
- Researchers have validated the accuracy of the International Association for the Study of Lung Cancer's (IASLC) 2009 pleural mesothelioma database, with these findings presented by Wolf et al at the IASLC 2023 World Conference on Lung Cancer (Abstract MA17.04). (ascopost.com)
- WEDNESDAY, Sept. 20, 2023 -- Patients with nonerosive gastroesophageal reflux disease (GERD) do not have an increased risk for esophageal adenocarcinoma compared with the general population, according to a study published online Sept. 13 in The. (medworm.com)
- A modified adenocarcinoma classification approach significantly enhances reproducibility and may be an improvement on the existing World Health Organization classification system, according to research unveiled at the International Association for the Study of Lung Cancer (IASLC) 2023. (medworm.com)
- FRIDAY, Sept. 1, 2023 -- For patients with human epidermal growth factor receptor 2 (HER2)-negative, locally advanced unresectable or metastatic gastric or gastroesophageal junction (mG/GEJ) adenocarcinoma, zolbetuximab, a monoclonal antibody that. (medworm.com)
- Bispecific Antibodies in Lung Cancer" Encyclopedia , https://encyclopedia.pub/entry/45901 (accessed December 11, 2023). (encyclopedia.pub)
- Cancer statistics, 2023. (msdmanuals.com)
- CA Cancer J Clin 73(1):17-48, 2023. (msdmanuals.com)
NSCLC35
- Non-small cell lung cancer (NSCLC) accounts for approximately 85% of all lung cancers. (medscape.com)
- Histologically, NSCLC is divided into adenocarcinoma, squamous cell carcinoma (SCC) (see the image below), and large cell carcinoma. (medscape.com)
- Because most lung cancers cannot be cured with currently available therapeutic modalities, the appropriate application of skilled palliative care is an important part of the treatment of patients with NSCLC. (medscape.com)
- Deeper understanding of the pathobiology of non-small cell lung cancer (NSCLC) has led to the development of small molecules that target genetic mutations known to play critical roles in the progression to metastatic disease. (medscape.com)
- Fusion between echinoderm microtubule-associated proteinlike 4 ( EML4 ) and ALK is seen in approximately 2-7% of patients with NSCLC adenocarcinomas. (medscape.com)
- ROS-1 gene alterations, thought to lead to abnormal cells, have been identified in various cancers, including NSCLC. (medscape.com)
- The principle of preferentially selecting patients most likely to benefit from therapy according to their genetic profile has led to substantial clinical benefit in some tumour types, and has potential to considerably refine treatment in advanced nonsmall cell lung cancer (NSCLC). (ersjournals.com)
- This review considers the current evidence linking biomarker profile to efficacy of epidermal growth factor receptor (EGFR)-targeted therapy in advanced nonsmall cell lung cancer (NSCLC) and the clinical implications of recent findings. (ersjournals.com)
- As reported in the Journal of Clinical Oncology by Goto et al, primary results of the phase II DESTINY-Lung02 trial have shown activity of fam-trastuzumab deruxtecan-nxki (T-DXd) in patients with HER2-mutant metastatic non-small cell lung cancer (NSCLC) previously treated with platinum-containing. (ascopost.com)
- In patients with advanced non-small cell lung cancer (NSCLC) harboring EGFR mutations, the role of immune checkpoint inhibitors following disease progression with tyrosine kinase inhibitors has been unclear. (ascopost.com)
- In the phase II HERTHENA-Lung01 trial reported in the Journal of Clinical Oncology, Helena Yu, MD, and colleagues found that patritumab deruxtecan (HER3-DXd), a new anti-HER3 antibody-drug conjugate, showed activity in patients with EGFR-mutated advanced non-small cell lung cancer (NSCLC). (ascopost.com)
- The oral KRAS G12C inhibitor adagrasib may offer durable clinical activity, with a median overall survival of 14.1 months and a 2-year survival rate of about 33%, in patients with KRAS G12C-mutated non-small cell lung cancer (NSCLC), according to findings presented by Gadgeel et al at the. (ascopost.com)
- Researchers have discovered that therapy with first-line nivolumab in combination with ipilimumab may improve the 6-year survival and quality of life of patients with metastatic non-small cell lung cancer (NSCLC) compared with standard chemotherapy, according to findings presented by Peters et al. (ascopost.com)
- The TROP-2-directed antibody-drug conjugate datopotamab deruxtecan may significantly improve progression-free survival in patients with metastatic non-small cell lung cancer (NSCLC), especially in patients with non-squamous cell tumors, according to new findings simultaneously published by Ahn et. (ascopost.com)
- Intensity-modulated radiation therapy (IMRT) reduced the risk of toxicity to the lungs and radiation exposure to the heart vs three-dimensional conformal radiotherapy (3D-CRT) for the treatment of locally advanced non-small cell lung cancer (NSCLC), according to a planned long-term prospective. (ascopost.com)
- Early-phase trials demonstrate the potential for TROP-2-directed antibody-drug conjugates to enhance the response to immune checkpoint inhibitors in patients with advanced non-small cell lung cancer (NSCLC) without actionable genomic alterations, several investigators reported at the International. (ascopost.com)
- Tina Cascone, MD, PhD, of The University of Texas MD Anderson Cancer Center, discusses new phase III findings from the CheckMate 77T trial of patients with previously untreated resectable stage II-IIIB non-small cell lung cancer (NSCLC). (ascopost.com)
- Compared with neoadjuvant chemotherapy alone, adding perioperative immunotherapy-given before and after surgery-significantly improved event-free survival in patients with resectable early-stage non-small cell lung cancer (NSCLC). (ascopost.com)
- The combination of the ATR inhibitor ceralasertib and the immune checkpoint inhibitor durvalumab has demonstrated notable survival rates and clinical benefits among patients who have advanced non-small cell lung cancer (NSCLC) with RAS mutations, according to data presented at the International. (ascopost.com)
- Complete surgical resection is the treatment of choice for operable early-stage non-small cell lung cancer (NSCLC) and resectable stage IIIA. (ascopost.com)
- On October 11, the U.S. Food and Drug Administration (FDA) approved the BRAF inhibitor encorafenib (Braftovi) with the MEK inhibitor binimetinib (Mektovi) for adult patients with metastatic non-small cell lung cancer (NSCLC) and a BRAF V600E mutation, as detected by an FDA-approved test. (ascopost.com)
- Clinical trial data continue to emerge on treatments in advanced non-small cell lung cancer (NSCLC), supporting the strategy that histology and molecular driver mutations should guide treatment selection. (jnccn.org)
- She was diagnosed with non-small cell lung cancer (NSCLC) with bone metastasis and pneumocystis pneumonia (PCP). (biomedcentral.com)
- Non-small cell lung cancer (NSCLC) is the most common type of lung cancer in pregnant women, accounting for approximately 85% of all gestational cancers [ 6 ]. (biomedcentral.com)
- Background The liver is a frequent site of metastases and liver metastases (LM) correlate with diminished immunotherapy efficacy in non-small cell lung cancer (NSCLC). (bmj.com)
- This study aimed to analyze whether tumor response to immunotherapy differs between pulmonary lesions (PL) and LM in NSCLC and to explore potential mechanisms through multiomics analysis. (bmj.com)
- B7-H1 and B7-H3, two members of the B7 family that are thought to regulate T-cell activation, are expressed in human non-small cell lung cancer (NSCLC). (oncotarget.com)
- Interferon-γ reduced CXCR4 expression on cancer cells and inhibited the CXCL12-induced cell migration.B7-H1 and B7-H3 are independent predictors of poorer survival in patients with NSCLC. (oncotarget.com)
- Although some improvements have been made, the five-year survival rate of NSCLC (16.6%) is still lower than many other leading cancers, such as the colon (64.2%), breast (89.2%) and prostate (99.2%) cancer. (oncotarget.com)
- The present study evaluated the prognostic value of the epidermal growth factor receptor (EGFR) mutation status, and excision repair cross-complementation group 1 (ERCC1) and thymidylate synthase (TS) expression following intercalated tyrosine kinase inhibitor (TKI) therapy and platinum- and pemetrexed-based chemotherapies (subsequent second-line treatment) for patients with adenocarcinoma non-small-cell lung cancer (AC-NSCLC). (medsci.org)
- It has been classified histologically into two major groups: small-cell lung cancer and non-small-cell lung cancer (NSCLC). (medsci.org)
- Adenocarcinoma, squamous cell carcinoma, bronchioalveolar carcinoma, and large cell carcinoma are the subtypes of NSCLC. (medsci.org)
- More than 80% of NSCLC cases are of the adenocarcinoma subtype (AC-NSCLC), whose incidence rate has steadily increased over the past decade. (medsci.org)
- Non-small cell lung cancer (NSCLC) contributes to around 85% of lung cancer diagnoses (vs. 15% for small cell lung cancer), which is further categorized into adenocarcinoma 78% and squamous 18% [ 2 ] . (encyclopedia.pub)
- Surgery is recommended for patients with stage I or II non-small cell lung cancer NSCLC) and may provide the best possibility for a cure. (medscape.com)
EGFR12
- Initial studies with the EGFR tyrosine kinase inhibitors (TKIs) gefitnib (Iressa) and erlotinib (Tarceva) demonstrated biologic and clinical activity in only a relatively limited subset of lung cancers. (medscape.com)
- In general, activating EGFR mutations are more commonly observed in patients with adenocarcinomas and no prior history of smoking, as well as in females and those of Asian descent. (medscape.com)
- [ 7 ] researchers identified EGFR mutations in 50.5% of surgically resected lung adenocarcinomas. (medscape.com)
- Use of the EGFR-TKIs gefitinib, erlotinib, and afatinib is limited to patients with adenocarcinomas who have known activating EGFR mutations. (medscape.com)
- The treatment of patients with epidermal growth factor receptor (EGFR)-mutated lung cancer that progresses on EGFR-targeted tyrosine kinase inhibitors has been challenging. (ascopost.com)
- In addition, molecular testing should be performed on all patients with adenocarcinoma as it provides even further information, revealing whether the tumor is negative for epidermal growth factor receptor (EGFR) and anaplastic lymphoma kinase (ALK) mutations, for instance. (jnccn.org)
- Unlike classical lung adenocarcinoma, the primary driver genes implicated in SMARCA4-dNSCLC, as revealed by molecular detection tests, primarily involve SMARCA4, TP53, KRAS and STK11 , while the more commonly associated driver genes like EGFR, ALK and ROS1 show no marked association ( 1 ). (spandidos-publications.com)
- The standard therapies for lung adenocarcinoma include epidermal growth factor receptor (EGFR) mutation targeted therapy and conventional chemotherapy, such as platinum- and pemetrexed-based chemotherapies. (medsci.org)
- Transformed SCC after TKI treatment in EGFR -mutant adenocarcinoma (AdenoCa) branched out early from the clones with completely inactivated RB1 and TP53 [ 7 ]. (e-crt.org)
- EGFR -mutant lung cancers with RB1 / TP53 alterations are at exceptionally high risk for SCC transformation [ 9 ]. (e-crt.org)
- The need for an alternative to physical biopsies is no more apparent than in lung cancer given the high risks associated with lung biopsies, as well as the discovery of actionable driver mutations like the epidermal growth factor receptor (EGFR) and anaplastic lymphoma kinase (ALK) for which targeted therapies now exist ( 3 - 5 ) together with identified resistance mutations to tyrosine kinase inhibitor therapy. (amegroups.org)
- Toward automatic prediction of EGFR mutation status in pulmonary adenocarcinoma with 3D deep learning. (cdc.gov)
Metastasis9
- The TNM (tumor-node-metastasis) staging system from the American Joint Committee for Cancer Staging and End Results Reporting is used for all lung carcinomas except small-cell lung cancer. (medscape.com)
- He underwent an en bloc resection, and pathological findings concluded to a metastasis of a pulmonary combined small cell carcinoma and adenocarcinoma. (hindawi.com)
- However, intussusception due to a jejunal metastasis of combined lung cancer is extremely rare [ 3 ]. (hindawi.com)
- Indeed, lung cancer metastasis to the bowel is uncommon, reported in less than 1% of patients [ 4 ]. (hindawi.com)
- In this present case, we report the observation of a patient who presented with an acute intestinal intussusception caused by a jejunal metastasis of pulmonary combined small cell carcinoma and adenocarcinoma and we present a review of the literature. (hindawi.com)
- The distinction between primary lung adenocarcinoma and pulmonary metastasis from the gastrointestinal (GI) tract may be difficult. (lu.se)
- Metastasis was confirmed to be adenocarcinoma by FNA or Biopsy when feasible, though several pulmonary masses were diagnosed based on radiography alone. (vin.com)
- CAFs provide cancer cells with nutrition and promote the proliferation, invasion and metastasis of cells ( 6 - 9 ). (spandidos-publications.com)
- An ego network analysis approach identified important biomarkers with an association to progression and metastasis of gastric cancer. (cdc.gov)
Tumor9
- Enzootic nasal adenocarcinoma Jaagsiekte sheep retrovirus Enzootic nasal tumor virus "2.7.9 Ovine pulmonary adenocarcinoma (adenomatosis)" (PDF). (wikipedia.org)
- Mammary cancer in cats is a common, highly aggressive tumor that requires aggressive therapy to control. (vin.com)
- Pulmonary tumor thrombotic microangiopathy (PTTM) is a complication characterized by dyspnea, pulmonary hypertension, and occasionally sudden death. (go.jp)
- Cancer-associated fibroblasts (CAFs) are one major type of component identified in the tumor microenvironment. (spandidos-publications.com)
- SWI/SNF‑related, matrix‑associated, actin‑dependent regulator of chromatin, subfamily a, member 4 (SMARCA4)‑deficient non‑small cell lung cancer (dNSCLC) is a rare malignant tumor that originates in the lungs. (spandidos-publications.com)
- A multimodal combination of circulating tumor DNAs (ctDNAs), CTCs, proteomics, and CTC-derived xenografts (CDXs) to create computational models useful in diagnosis, prognostication, and predictiveness to treatment is likely the future of tailoring individualized cancer care. (amegroups.org)
- Thus, there exists the appeal of a so-called "liquid biopsy" that can less invasively act as a reliable surrogate for tumor biopsies, yet provide as much or even more information pertinent to cancer diagnosis, characteristics, and treatment options. (amegroups.org)
- The first report of a CTC came in 1869 from Thomas Ashworth, who described the presence of tumor-derived epithelial cells in the blood compartment of a patient with end stage metastatic cancer, and postulated that this circulation of cells may account for the presence of multiple tumor metastases throughout the body of the patient ( 6 ). (amegroups.org)
- Universal tumor DNA BRCA1/2 testing of ovarian cancer: prescreening PARPi treatment and genetic predisposition. (cdc.gov)
Tumors2
Clinical16
- From one such study, it appeared that mutational testing should become standard at diagnosis, at least for adenocarcinoma patients with a never or low smoking history, as clinical predictors are insufficient to optimise treatment. (ersjournals.com)
- Therapies tailored to specific genetic lesions and diagnostic tests that assay for their respective molecular targets are now an established part of clinical practice across various tumour types, including chronic myeloid leukaemia 1 , gastrointestinal stromal tumours and epithelial tumours, such as breast and colon cancer 2 . (ersjournals.com)
- Clinical practice in colon cancer also reflects the need for mutational testing to identify patients most likely to benefit from cetuximab: patients whose tumours lack a KRAS mutation (also called wild-type) show significantly increased overall survival (OS) (median 9.5 versus 4.8 months) with cetuximab, whereas those with KRAS mutations do not benefit from therapy 4 . (ersjournals.com)
- The biomarker-driven Lung Cancer Master Protocol (Lung-MAP) may have enrolled a higher percentage of patients who are older, are from rural or socioeconomically deprived areas, and have Medicaid or no insurance compared with conventional, standalone clinical trials in advanced non-small cell lung. (ascopost.com)
- The second part of the review discusses potential host-directed interventional strategies based on existing translational and clinical knowledge of infection-induced inflammation, as well as cancer initiation/progression models. (frontiersin.org)
- The study was supported by Swedish governmental funding of clinical research (ALF), the Franke and Margareta Bergqvist Foundation, and the Swedish Cancer Society. (lu.se)
- A lower body mass index, interstitial lung disease, prior pulmonary tuberculosis, larger clinical target volume, history of lung cancer surgery or radiation pneumonitis, and use of inhaled corticosteroids were independent risk factors for CPI development. (e-crt.org)
- A clinical study to evaluate of the combination of AHCC plus PLD in the treatment of ovarian cancer is being pursued. (researchgate.net)
- Fig 1 Example of stratified medicines research, with translation from discovery of human epidermal growth factor receptor 2 (HER-2) status as a prognostic factor for metastatic breast cancer 5 to development of trastuzumab treatment and use in clinical practice. (bmj.com)
- After total thyroidectomy (performed in Patient 2 only) and 131I therapy (cumulative dose of 12.3 GBq in Patient 1 and 9.6 GBq in Patient 2), there was a rapid clinical improvement with significant reduction of the pulmonary metastatic disease in both patients: Patient 1 became euthyroid, while Patient 2 became hypothyroid. (unicatt.it)
- See Clinical Presentations of Lung Cancer: Slideshow , a Critical Images slideshow, to help efficiently distinguish lung carcinomas from other lung lesions, as well as how to stage and treat them. (medscape.com)
- Development, technical validation, and clinical application of a multigene panel for hereditary gastrointestinal cancer and polyposis. (cdc.gov)
- Feasibility and clinical utility of endoscopic ultrasound guided biopsy of pancreatic cancer for next-generation molecular profiling. (cdc.gov)
- This study documents for the first time the clinical and epidemiological characteristics of lung cancer cases in Qatar from 1998 to 2005. (who.int)
- The aim of the present study was to document the clinical and epidemiological characteristics of lung cancer cases in Qatar. (who.int)
- To address this aim we have designed the lungNENomics study, an international cohort of over 250 cases of pulmonary carcinoids, with clinical data and central pathology review, as well as whole-genome sequencing, RNA sequencing, DNA methylation array, and digital spatial profiling data. (who.int)
Carcinoma9
- Squamous cell carcinoma was the most common type of lung cancer in IPF patients. (nih.gov)
- It has also been known as sheep pulmonary adenomatosis and ovine pulmonary carcinoma. (wikipedia.org)
- [ 3 , 4 ] The term "pseudomesotheliomatous carcinoma" was first applied by Harwood and colleagues in 1976 to 6 cases of peripheral lung adenocarcinoma that closely mimicked mesothelioma. (medscape.com)
- Adenocarcinoma in situ was previously known as bronchioloalveolar carcinoma. (cancer.org)
- Mendelian randomization analyses demonstrate that reduced FEV 1 increases squamous cell carcinoma risk (odds ratio (OR) = 1.51, 95% confidence intervals: 1.21-1.88), while reduced FEV 1 /FVC increases the risk of adenocarcinoma (OR = 1.17, 1.01-1.35) and lung cancer in never smokers (OR = 1.56, 1.05-2.30). (nature.com)
- The most common histological change is the switch from adenocarcinoma (AdenoCa) to small cell carcinoma (SCC) against to tyrosine kinase inhibitors (TKI). (e-crt.org)
- Lung carcinoma is the leading cause of cancer-related death in men and women worldwide. (msdmanuals.com)
- Biomarkers of the transsulfuration pathway and risk of renal cell carcinoma in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. (who.int)
- To have been diagnosed before March 12, 2012 with: a) Lung cancer or b) Cancer (squamous cell carcinoma) of the throat, that is to say of the larynx, the oropharynx or the hypopharynx or c) Emphysema. (who.int)
Histologically4
- Seventy IPF patients with histologically proven lung cancer were identified through a search of the Seoul National University Bundang Hospital database between 2003 and 2012. (nih.gov)
- OPA has been used as an animal model for human lung cancer, because OPA is histologically similar to human adenocarcinoma in situ of the lung. (wikipedia.org)
- The multicenter, randomized, double-blind, placebo-controlled KEYNOTE-859 trial enrolled patients with histologically or cytologically confirmed locally advanced or metastatic adenocarcinoma of the stomach or GEJ who received no prior treatment, had a known PD-L1 status, were HER2 negative and had an ECOG performance status of 0 or 1. (ajmc.com)
- The objective of the present work was to analyse the VOCs in alveolar air to build a diagnostic tool able to identify the presence of pancreatic ductal adenocarcinoma in patients with histologically confirmed disease. (biomedcentral.com)
DIAGNOSIS6
- Diagnosis of pulmonary hemosiderosis by MR imaging. (radiopaedia.org)
- Cats were required to have a complete medical record including a histologic diagnosis of mammary adenocarcinoma, with metastatic disease confirmed based on physical exam (PE), ultrasound, radiographs or CT. (vin.com)
- The current case report further accentuates the intricate landscape of lung cancer subtypes and highlights the importance of a nuanced understanding of their molecular underpinnings to guide accurate diagnosis and tailored therapeutic approaches. (spandidos-publications.com)
- 23 patients with histological diagnosis of pancreatic adenocarcinomas and 25 controls were correctly identified by the model. (biomedcentral.com)
- In both patients, a simultaneous diagnosis of thyrotoxicosis and metastatic thyroid cancer was made, based on thyroid function tests as well as 131I whole-body scans showing low thyroid uptake of radioiodine and multiple foci of intense 131I uptake in the lungs. (unicatt.it)
- Socioeconomic status, access to care, risk factor patterns, and stage at diagnosis for head and neck cancer among black and white patients. (who.int)
Colorectal cancer12
- Tissue microarrays from 629 resected primary lung cancers and 422 resected pulmonary epithelial metastases from various sites (whereof 275 colorectal cancer) were investigated for the immunohistochemical expression of CDH17, GPA33, MUC2, MUC6, SATB2, and SMAD4, for comparison with CDX2, CK20, CK7, and TTF-1. (lu.se)
- Aberrant Expression and Subcellular Localization of ECT2 Drives Colorectal Cancer Progression and Growth. (charite.de)
- Mutation-specific effects of NRAS oncogenes in colorectal cancer cells. (charite.de)
- It is difficult to separate epidemiological considerations of rectal cancer from those of colon cancer because studies often consider colon and rectal cancer together (i.e., colorectal cancer). (cancer.gov)
- Worldwide, colorectal cancer is the third most common form of cancer. (cancer.gov)
- In 2020, there were an estimated 1.93 million new cases of colorectal cancer and 935,173 deaths. (cancer.gov)
- Colorectal cancer affects men and women almost equally. (cancer.gov)
- Among all racial groups in the United States, Black individuals have the highest sporadic colorectal cancer incidence and mortality rates. (cancer.gov)
- Family history of colorectal cancer in a first-degree relative. (cancer.gov)
- Evidence supports screening for rectal cancer as a part of routine care for all adults aged 50 years and older, especially for those with first-degree relatives with colorectal cancer. (cancer.gov)
- For more information, see Colorectal Cancer Screening . (cancer.gov)
- Wild-type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer. (nature.com)
Nodule4
- Hello everyone, I am 56-year old former smoker (quit 7 years ago) and was just diagnosed with Adenocarcinoma In Situ based on needle biopsy done on a 1.3cm nodule in my right middle robe. (cancer.org)
- The purpose of this study was to assess the effects of IV contrast medium and different CT scan delays on volumetric measurements of pulmonary nodule. (ajronline.org)
- We recommend comparing volume of pulmonary nodules obtained from CT examinations only if they are all performed with or without contrast material, whereas nodule volumes obtained by use of enhanced CT performed with different scan delays are comparable. (ajronline.org)
- Fig. 1 - 59-year-old woman with right lower lobe pulmonary nodule. (ajronline.org)
Mucinous adenocarcinomas3
- MUC2 was negative in all primary lung cancers, but positive only in less than half of pulmonary metastases from mucinous adenocarcinomas from other organs. (lu.se)
- Combining six GI markers did not perfectly separate primary lung cancers from pulmonary metastases including subgroups such as mucinous adenocarcinomas or CK7-positive GI tract metastases. (lu.se)
- Despite its drawbacks, immunohistochemistry is often employed to help assign a primary site for mucinous adenocarcinomas in the lung. (wustl.edu)
Idiopathic2
- Idiopathic pulmonary fibrosis (IPF) is reportedly associated with an increased risk of lung cancer. (nih.gov)
- Idiopathic pulmonary hemosiderosis. (radiopaedia.org)
Epithelial3
- Annexin A2 and S100A10 as Candidate Prognostic Markers in Epithelial Ovarian Cancer. (cancerindex.org)
- The aim of this study was to examine whether Annexin A2 and S100A10 expression can be used as prognostic markers for epithelial ovarian cancer (EOC). (cancerindex.org)
- Many cancers originate from stem or progenitor cells hijacked by somatic mutations that drive replication, exemplified by adenomatous transformation of pulmonary alveolar epithelial type II (AT2) cells1. (stanford.edu)
Mutations3
- KRAS mutations are also predominantly found in adenocarcinomas and are seen in approximately 25% of cases. (medscape.com)
- Invariably, the development of new mutations, changes in cancer cell populations, and other resistance mechanisms lead to therapeutic resistance. (amegroups.org)
- Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. (nature.com)
Nodules7
- Multiple pulmonary nodules in my lung were first discovered by CT (taken because I was feeling shortness of breath) in 2005 and they were monitored every 6 months for three years and every year after that and no change in size was observed in any of the nodules until the last CT taken two weeks ago. (cancer.org)
- Diffuse pulmonary nodules. (radiopaedia.org)
- Automated volumes of 35 pulmonary nodules were calculated with two dedicated software packages (designated as software A and software B) for each unenhanced and contrast-enhanced CT scan at 30-, 60-, 120-, 180-, and 300-second delays (injection protocol, 2 mL/s and 2 mL/kg). (ajronline.org)
- CT follow-up of lung nodules is commonly used to assess potential growth of undetermined lesions and to evaluate therapeutic response of pulmonary metastases. (ajronline.org)
- Thus, the aim of this study was to assess the effects of IV contrast material and different CT scan delays on automated volume measurement of pulmonary nodules and to determinate whether different software packages provide different contrast-enhanced measurements. (ajronline.org)
- All data used in this retrospective study were collected from a previous research protocol aimed at diagnosing the nature of undetermined pulmonary nodules and small mass lesions by dynamic contrast enhancement study. (ajronline.org)
- slideshow for more information on benign and malignant etiologies of solitary pulmonary nodules and the Cutaneous Clues to Diagnosing Metastatic Cancer slideshow to help identify various skin lesions that are cause for concern. (medscape.com)
Chronic7
- Ovine pulmonary adenocarcinoma (OPA), also known as ovine pulmonary adenomatosis, or jaagsiekte, is a chronic and contagious disease of the lungs of sheep and goats. (wikipedia.org)
- This study aimed to investigate cumulative incidence and risk factors associated with chronic pulmonary infection (CPI) development after radiotherapy for lung cancer. (e-crt.org)
- CPI was defined as pulmonary tuberculosis, non-tuberculous mycobacterial pulmonary disease, chronic pulmonary aspergillosis, or pulmonary actinomycosis. (e-crt.org)
- Chronic pulmonary infections (CPIs), such as pulmonary tuberculosis (PTB), non-tuberculous mycobacterial pulmonary disease (NTM-PD), and chronic pulmonary aspergillosis (CPA), usually occur in patients with underlying lung diseases. (e-crt.org)
- The risk factors for CPI include fibronodular lesions on chest images, the presence of bronchiectasis or chronic obstructive pulmonary disease (COPD), and sequelae of PTB [ 6 - 8 ]. (e-crt.org)
- Chronic inflammation increases the risk of many cancers, including lung cancer. (msdmanuals.com)
- Chronic Obstructive Pulmonary Disease (COPD) Chronic obstructive pulmonary disease (COPD) is airflow limitation caused by an inflammatory response to inhaled toxins, often cigarette smoke. (msdmanuals.com)
Alveolar microlithiasis1
- Insights into pulmonary phosphate homeostasis and osteoclastogenesis emerge from the study of pulmonary alveolar microlithiasis. (uc.edu)
Pathology2
- Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas. (bvsalud.org)
- MMP-12 (macrophage elastase) is implicated in the pathology of many diseases such as emphysema, aortic lesions and cancer. (anaspec.com)
Abstract1
Incidence9
- In a study reported in a research letter in JAMA Oncology, Jemal et al found that rates of lung cancer declined more in men vs women in the United States in recent years, such that incidence is now higher in women vs men aged ≤ 55 years. (ascopost.com)
- MedPage Today) -- Patients with non-erosive gastroesophageal reflux disease (GERD) appear to have a similar incidence of esophageal adenocarcinoma as the general population, according to a large Nordic population-based cohort study with up to. (medworm.com)
- The long-term survival rate of lung cancer patients receiving radiotherapy was not low, but the cumulative incidence of CPI gradually increased to 6.8% at 7 years after radiotherapy. (e-crt.org)
- the impact on future lung cancer incidence rates needs further investigation. (cdc.gov)
- Lifestyle and cancer incidence and mortality risk depending on family history of cancer in two prospective cohorts. (cdc.gov)
- National and Regional Fraction of Cancer Incidence and Death Attributable to Current Tobacco and Water-Pipe Smoking in the Eastern Mediterranean Countries in 2020. (who.int)
- Background: In some settings, lung cancer incidence appears higher among disadvantaged groups. (who.int)
- We analyzed the harmonized database of the Lung Cancer Cohort Consortium (LC3) to assess the relationship between socioeconomic status and lung cancer incidence across different world regions. (who.int)
- Among current/former smoking participants, higher educational level was associated with decreased lung cancer incidence in nearly all cohorts. (who.int)
Division of Pulmonary1
- 1 Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Ulsan College of Medicine, Ulsan University Hospital, Ulsan, Republic of Korea. (nih.gov)
Histologic3
- IPF reduced the survival of surgically treated lung cancer patients regardless of age, sex, histologic type, and/or lung cancer stage. (nih.gov)
- Only adenocarcinoma in situ is identified in the histologic sections examined. (cancer.org)
- Histologic change is a resistant mechanism in lung cancer. (e-crt.org)
Lung cancer etiology2
- These findings support a causal role of pulmonary impairment in lung cancer etiology. (nature.com)
- Design and methodological considerations for biomarker discovery and validation in the Integrative Analysis of Lung Cancer Etiology and Risk (INTEGRAL) Program. (who.int)
Primary pulmonary1
- [ 12 ] Rare cases of primary pulmonary or pleural DSRCT have subsequently been identified. (medscape.com)
Epidermal growth f2
- Clinically relevant improvements in survival have been attained by administering targeted therapy to the appropriate patient population: for example, the addition of trastuzumab to standard first-line chemotherapy in patients with human epidermal growth factor receptor-positive (HER2+) metastatic breast cancer 3 . (ersjournals.com)
- Arriola E, Taus Á, Casadevall D. Is there a role for epidermal growth factor receptor tyrosine kinase inhibitors in epidermal growth factor receptor wild-type non-small cell lung cancer? (imim.es)
Prognostic4
- Prognostic values of S100 family members in ovarian cancer patients. (cancerindex.org)
- While the prognostic value of each individual S100 in ovarian cancer is still elusive. (cancerindex.org)
- In current study, we investigated the prognostic value of S100 family members in the ovarian cancer. (cancerindex.org)
- Metastatic feline mammary cancer: prognostic factors, outcome and comparison of different treatment modalities - a retrospective multicentre study. (vin.com)
Chemotherapy10
- The combination of benmelstobart, anlotinib, and chemotherapy may be effective at improving median progression-free survival and overall survival in patients with extensive-stage small cell lung cancer compared with placebo and chemotherapy, according to findings presented by Cheng et al at the. (ascopost.com)
- Purpose: Pembrolizumab is currently used to treat advanced triple-negative breast cancer (TNBC) and high-risk early TNBC with neoadjuvant chemotherapy (NAC). (koreamed.org)
- He was diagnosed with PTTM with adenocarcinoma by a transbronchial lung biopsy and received chemotherapy and anticoagulant therapy. (go.jp)
- These finding are particularly beneficial in the treatment of recurrent cancer when maintaining a good quality of life during chemotherapy is a priority and allows patients to have a natural, nutritional approach to preventing and managing chemotherapy adverse effects. (researchgate.net)
- 2 ] By focusing on cancer-specific molecular changes, targeted cancer therapies may be more effective than other traditional treatments, such as chemotherapy and radiotherapy, and less harmful to normal cells. (oncotarget.com)
- The FDA has approved pembrolizumab (Keytruda) in combination with fluoropyrimidine- and platinum-containing chemotherapy for the first-line treatment of adult patients with locally advanced unresectable or metastatic, HER2-negative gastric or gastroesophageal junction adenocarcinoma. (ajmc.com)
- The FDA has approved pembrolizumab (Keytruda) in combination with fluoropyrimidine- and platinum-containing chemotherapy for the first-line treatment of adults with locally advanced unresectable or metastatic, HER2-negative gastric or gastroesophageal junction (GEJ) adenocarcinoma. (ajmc.com)
- Cancer chemotherapy is in evolution from non-specific cytotoxic drugs that damage both tumour and normal cells to more specific agents and immunotherapy approaches. (nature.com)
- Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2 . (nature.com)
- DNA repair by ERCC1 in non small cell lung cancer and cisplatin-based adjuvant chemotherapy. (nature.com)
Progression7
- Higher checkpoint inhibitor arthritis disease activity may be associated with cancer progression. (wjgnet.com)
- In a phase II trial reported in JAMA Oncology, Takahashi et al found that the addition of the ataxia telangiectasia and Rad3-related (ATR) kinase inhibitor berzosertib to topotecan did not improve progression-free survival in patients with relapsed small cell lung cancer (SCLC). (ascopost.com)
- Molecular portraits of cell cycle checkpoint kinases in cancer evolution, progression, and treatment responsiveness. (uc.edu)
- RON-augmented cholesterol biosynthesis in breast cancer metastatic progression and recurrence. (uc.edu)
- Due to the critical role of CAFs during cancer progression, the genetic characterization of CAFs aids in the investigation of cancer therapy. (spandidos-publications.com)
- Finally, CAFs promote cancer progression and act in cancer cell drug resistance. (spandidos-publications.com)
- Immune evasion is now recognized as a key feature of cancer progression. (oncotarget.com)
Risk of lung cancer2
Diffuse2
- An autopsy revealed primary gastric cancer with PTTM that can have a presentation similar to diffuse pulmonary diseases, including chemical inhalation lung injury. (go.jp)
- A few notes on each cancer site and its subgroups staining techniques (e.g., glandular and diffuse neoplasms of are included in this chapter. (who.int)
Ovarian cancer3
- Ovarian cancer (OC) is the 5th most common cancer among European women. (cancerindex.org)
- Scientific Methods: In vitro growth inhibition assays were completed with AHCC alone and in combination with PLD in panel of human cancer cell lines and findings confirmed in vivo in an ovarian cancer xenograft mouse model. (researchgate.net)
- Industrial Relevance: This study presents an example of the successful integration of a well- known herbal supplement, AHCC, with traditional western medicine cytotoxic agent, pegylated liposomal doxorubicin, for the treatment of recurrent ovarian cancer. (researchgate.net)
Metastases3
- The most sensitive markers for GI origin were GPA33 (positive in 98%, 60%, and 100% of pulmonary metastases from. (lu.se)
- We report two cases of thyrotoxicosis resulting from hyperfunctioning lung metastases from differentiated thyroid cancer. (unicatt.it)
- Analysis of the 54 cases reported in the literature, including the 2 cases described here, shows this to be a very rare cause of thyrotoxicosis and one that can pose serious problems for both the diagnostic evaluation and choice of therapeutic strategy when compared with the much more common nonhyperfunctioning metastases from thyroid cancer. (unicatt.it)
Molecular3
- Peppercorn, J., Perou, C. M. & Carey, L. A. Molecular subtypes in breast cancer evaluation and management: divide and conquer. (nature.com)
- Molecular Diagnostic and Prognostication Assays for the Subtyping of Urinary Bladder Cancer Are on the Way to Illuminating Our Vision. (who.int)
- While progress has been made in recent years in the characterisation of pulmonary carcinoids, little is known about the underlying biology or developmental origins of these molecular groups, hampering efforts to identify predictive markers and suitable therapeutic options. (who.int)
Obstructive1
- Lung cancer and obstructive pulmonary disease share multiple etiological factors, such as cigarette smoking, occupational inhalation hazards, and air pollution, and 50-70% of lung cancer patients present with co-existing COPD or airflow obstruction 6 . (nature.com)
Oncology2
- Department of Thoracic, Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas. (bvsalud.org)
- Diseases for Oncology (ICD-O-2)) that were used for tabulation of Diagnostic subgroups are presented for 15 cancers, as defined by the major types of sarcoma, and for mesotheliomas. (who.int)
Survival6
- However, few studies have explored whether IPF affects the long-term survival of lung cancer patients. (nih.gov)
- The primary goal of this study was to evaluate the characteristics of lung cancer in IPF patients and impact of IPF on lung cancer survival. (nih.gov)
- Among surgically treated patients (33 cases and 66 controls), the 5-year survival rates were 38% for lung cancer patients with IPF and 73% for those without IPF (p = 0.001). (nih.gov)
- Overall lung cancer survival rates have improved over the past few decades with the advances made in diagnostic and therapeutic modalities [ 1 ]. (e-crt.org)
- 20 - 25 ] A major pooled analysis evaluating the impact of T and N stage and treatment on survival and relapse in patients with rectal cancer who are treated with adjuvant therapy confirmed these findings. (cancer.gov)
- A gene expression signature as a predictor of survival in breast cancer. (nature.com)
Disease6
- See also Lung Cancer Staging -- Radiologic Options , a Critical Images slideshow, to help identify stages of the disease process. (medscape.com)
- Here, we report a severe case of IA with high arthritis disease activity in advanced pulmonary adenocarcinoma, causing permanent withdrawal of pembrolizumab, but the patient remained in complete remission (CR) 20 mo after the development of IA. (wjgnet.com)
- 4. Woolley K, Stark P. Pulmonary parenchymal manifestations of mitral valve disease. (radiopaedia.org)
- Disentangling the role of pulmonary impairment in lung cancer development is important from an etiological perspective, for refining disease susceptibility mechanisms, and for informing precision prevention and risk stratification strategies. (nature.com)
- Adenopathy, hepatomegaly, or pulmonary signs may be present with metastatic disease. (cancer.gov)
- Although pulmonary carcinoids show relatively good prognosis in comparison to carcinomas, metastatic disease and relapse do occur. (who.int)
Lesions1
- See the Critical Images slideshow Cutaneous Clues to Diagnosing Metastatic Cancer to help identify various skin lesions that are cause for concern. (medscape.com)
Prognosis3
- Evidence on the average prognosis 1 and effectiveness of therapeutic interventions is available from studies of large groups of patients with breast cancer in observational studies and randomised trials. (bmj.com)
- 2 The use of HER-2 status in breast cancer management is an example of the translation of results from prognosis research toward improved patient outcomes. (bmj.com)
- A genomic strategy to refine prognosis in early stage non small cell lung cancer. (nature.com)
Pancreatic cancer1
- Pancreatic cancer is able to alter the concentration of some molecules in the blood and hence of VOCs in the alveolar air in equilibrium. (biomedcentral.com)
Radiographs1
- It is one of several described signs of pulmonary embolus on chest radiographs . (radiopaedia.org)
Monoclonal1
- To our knowledge, this is the first published case of sarcoid‐like pulmonary lymphadenopathy associated with durvalumab, a monoclonal antibody against programmed death ligand‐1 (PD‐L1). (doaj.org)
Pathologist2
- At WCLC23 pathologist Erik Thunnissen presented a study comparing modified classification to the WHO classification of pulmonary adenocarcinoma. (bpno.se)
- This distinction often falls to the pathologist in patients with a history of mucinous adenocarcinoma of the colon. (wustl.edu)
Gastric Cancer2
- Background/Aims: AT-rich interactive domain 1A (ARID1A) is frequently mutated in gastric cancer (GC), especially Epstein-Barr virus (EBV)-associated and microsatellite instability high GC. (koreamed.org)
- Meat consumption and risk of esophageal and gastric cancer in the Golestan Cohort Study, Iran. (who.int)
Mortality5
- Lung cancer is the most commonly diagnosed cancer worldwide and the leading cause of cancer mortality 1 . (nature.com)
- Cancer case during pregnancy is rare, but it is the second leading cause of maternal mortality. (biomedcentral.com)
- The use of low-dose computed tomography (CT) imaging has proved effective for early detection of lung cancer and consequent mortality reduction [ 2 ]. (e-crt.org)
- Lung cancer is the leading cause of cancer-related mortality worldwide, particularly in highly developed counties [ 1 ]. (medsci.org)
- Lung cancer is currently the most frequently diagnosed major cancer and is the leading cause of cancer-related mortality in both men and women worldwide [1]. (who.int)
Arterial2
- WNT7A deficit is associated with dysfunctional angiogenesis in pulmonary arterial hypertension. (stanford.edu)
- INTRODUCTION: Pulmonary arterial hypertension (PAH) is characterized by loss of microvessels. (stanford.edu)
Diseases2
- Furthermore, reverse causality remains a concern since pulmonary symptoms may be early manifestations of lung cancer or acquired lung diseases in patients whose immune system has already been compromised by undiagnosed cancer. (nature.com)
- The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
Investigation1
- Pan-cancer analysis of pre-diagnostic blood metabolite concentrations in the European Prospective Investigation into Cancer and Nutrition. (who.int)
Pathways2
- Integrative analyses reveal that pulmonary function instruments, including 73 novel variants, influence lung tissue gene expression and implicate immune-related pathways in mediating the observed effects on lung carcinogenesis. (nature.com)
- The Wnt pathways control pulmonary angiogenesis, but their role in PAH is incompletely understood. (stanford.edu)