Cancers proteins metastasis. Medical search. Frequent questions

To collect response data on triple-negative breast cancer, Bargonetti's team exposed mouse-model groups to cells with knocked-down MDMX or MDM2 genes. (cuny.edu)
When researchers compared these groups to a mouse-model that received triple negative breast cancer cells expressing the two genes, they found a 96 percent reduction in circulation tumor cells (CTCs) in the mouse model that received the knocked-down MDMX cells and a 78 percent reduction in CTCs in mouse model that received the knocked-down MDM2 cells. (cuny.edu)
The MDMX and MDM2 genes are expressed in multiple breast cancer subtypes. (cuny.edu)
Determining these genes' unique effect on tumor development and metastases in various types of cancer could help researchers identify new drug targets, novel therapies and create more precise treatment regimens. (cuny.edu)
In a screen for genes involved with prostate cancer metastasis, we found that 4.1B expression is reduced in highly metastatic tumors. (umn.edu)
Genetic knockdown of the particular genes in cancer cells were achieved by lentiviral-mediated interference. (biomedcentral.com)
To date, 1527 human miRNAs have been identified (Sanger miRBase 18 http://www.miRbase.org/index.shtml), forming less than 1% of all human genes, potentially regulating more than 10% of all protein coding genes [ 1 ]. (intechopen.com)
To evaluate the role of mitochondrial genes, stem cell-specific genes and DNA repair genes in cancer development, their mutation frequency was determined via further analysis. (biomedcentral.com)
This study has provided researchers with a publicly available data repository for studying both CATH and Pfam domain regions on protein-coding genes. (biomedcentral.com)
Moreover, the associations between different groups of genes/domains and various cancer types have been clarified. (biomedcentral.com)
Even though there has been some degree of success in identifying genes that are strongly associated with cancer, much is yet to be done for discovering causal genes and variants. (biomedcentral.com)
Cancer type-specific alterations in actin genes : worth a closer look? (ugent.be)
The genetic study showed promising results in "silencing" the genes that translate into tau protein, the primary component behind dementia. (medicaldaily.com)
135 antibodies against 65 mainly immunoregulatory proteins, we of a multitude of different genes (8, 9). (lu.se)
Here we examined 145 SNPs in 6 miRNA processing genes and in 78 miRNAs which target genes known to be important in breast cancer among 906 African American (AA) and 653 European American (EA) cases and controls enrolled in the Women's Circle of Health Study (WCHS). (cdc.gov)
We found a number of SNPs in miRNAs and processing genes in association with breast cancer overall or stratified by estrogen receptor (ER) status. (cdc.gov)
Variants in motilin, somatostatin and their receptor genes and risk of biliary tract cancers and stones in Shanghai, China. (cdc.gov)
Asynchronous DNA Replication of Biallelically Expressed Genes in Human Peripheral Blood Lymphocytes as a Prognostic Sign of Cancer. (cdc.gov)

Recent studies have shown that extracellular vesicles (EVs) can be exploited by tumors to assist in cancer cell growth, proliferation, migration, invasion and metastasis. (springer.com)
Mechanistic studies further reveal that the binding of NAP1 to the cellular chaperone heat shock protein 90 (HSP90) is required for its protein stabilization, and NAP1 plays an essential role in HSP90-mediated invasion and metastasis by provoking MMP9 activation and the epithelial-to-mesenchymal transition in NSCLC cells. (biomedcentral.com)
WASF3 is a tumor metastasis driver in breast cancer, and its knockdown leads to a significant reduction in metastatic breast cancer cell invasion and metastasis in mice [ 5 ]. (biomedcentral.com)
AXL significantly promotes tumour cell migration, invasion and metastasis, as well as angiogenesis. (cancerindex.org)
Sp2 promotes invasion and metastasis of hepatocellular carcinoma by targeting TRIB3 protein. (nih.gov)
Invasion and Metastasis (1998) 18 (4): 209-218. (karger.com)
In recent years, emerging studies have highlighted the critical role of these pathways and their regulation by microRNAs (miRNAs) in cancer invasion and metastasis. (intechopen.com)
The MVP metabolic pathway is up-regulated in certain breast cancers by the mutations in the tumor suppressor p53, allowing for enhancement in some cancer cell invasion and metastasis. (pharmacytimes.com)
To explore the mechanism of pancreatic cancer development, development, invasion and metastasis, in this study we focused on long non-coding RNA (LncRNA), which has been reported to be involved in tumorigenesis. (jcancer.org)
Taken together, LINC00673 can through suppress miR-504/ HNF1A regulating invasion and migration in pancreatic cancer. (jcancer.org)
Progress in the diagnosis and treatment of pancreatic cancer depends on elucidation of the pathophysiological mechanisms involved, and it is important to study the mechanisms of pancreatic cancer development, invasion and metastasis. (jcancer.org)
LncRNAs involved in tumor cell proliferation, apoptosis, invasion and metastasis [ 4 ] . (jcancer.org)
Overexpression of LINC00673 promotes invasion and metastasis which associated with a poor prognosis in tongue squamous cell carcinoma [ 6 ] . (jcancer.org)
Thus, this paper discusses some of the emerging molecular targets that have provided insights into the cascade of metastases in lung cancer with the focus on bone invasion. (hindawi.com)
Our laboratory focusses on how WNT5A expression is regulated in these cancers and deciphering the WNT5A signaling pathways governing cancer cell migration and invasion. (lu.se)
[ 4 ] It has been suggested that the MUC1 protein and its overexpression may be causally related to cancer invasion and metastasis. (medscape.com)
HIFs exert differential effects on tumor growth and affect important cancer hallmarks including cell proliferation, apoptosis, differentiation, vascularization/angiogenesis, genetic instability, tumor metabolism, tumor immune responses, and invasion and metastasis. (lu.se)

Protein 4.1B suppresses prostate cancer progression and metastasis. (umn.edu)
Dive into the research topics of 'Protein 4.1B suppresses prostate cancer progression and metastasis. (umn.edu)
Our findings indicate importance of both proteins for breast cancer progression and metastasis. (muni.cz)

Objective To investigate the correlation between metastasis-associated protein 3 (MTA3) and the prognosis of patients with breast cancer. (shsmu.edu.cn)
The expression of MTA3 protein was detected by immunohistochemical method and the correlation between the expression of MTA3 and the prognosis was analyzed. (shsmu.edu.cn)
For EGFR+/ER+ breast cancer, the expression of MTA3 in cancer tissues did not correlate to the prognosis (P=0.405). (shsmu.edu.cn)
Conclusion The function of MTA3 may be bi-directionally regulated by EGFR and ER pathways, so as to affect the prognosis of patients with breast cancer. (shsmu.edu.cn)
Meta-analysis of the effect of BRAF gene mutation on the prognosis of colorectal cancer patients with liver metastases after hepatectomy [J]. JOURNAL OF SHANGHAI JIAOTONG UNIVERSITY (MEDICAL SCIENCE), 2021, 41(6): 786-792. (shsmu.edu.cn)
Study on the function and prognosis of circular RNA in colorectal cancer tissues based on high-throughput sequencing [J]. JOURNAL OF SHANGHAI JIAOTONG UNIVERSITY (MEDICAL SCIENCE), 2021, 41(2): 187-195. (shsmu.edu.cn)
Metastatic cancer is a complex disease associated with poor prognosis and accounts for the majority of cancer related deaths. (springer.com)
Whether or not the cancer has spread to the lymph nodes can affect a patient's prognosis, particularly after surgery. (sciencedaily.com)
This type of cancer is associated with aggressive behavior and an overall poor prognosis 16 . (nature.com)
Aggressive breast cancer is a highly heterogeneous disease caused by a variety of distinct cell-intrinsic genetic alterations in mammary epithelial cells, leading to vastly heterogenic disease manifestation in individual patients and predominantly affecting patient prognosis and treatment options [ 14 ]. (nature.com)
Pancreatic cancer is a highly invasive type of malignant tumor with a very poor prognosis [ 1 ] . (jcancer.org)
The prognosis is dependent on the stage of the disease and extent of metastases. (hindawi.com)
The risk of distant recurrence in breast cancer patients is difficult to prognostic indices, such as the Nottingham Prognostic Index (6, 7), assess with current clinical and histopathological parameters, and have proven valuable in identifying patients with poor prognosis. (lu.se)
As a consequence, HIFs mediate resistance to chemo- and radiotherapy and are associated with poor prognosis in cancer patients. (lu.se)
we found that the expression of cartilage protein COMP is associated with metastases and a poor prognosis for patients with various types of solid cancers. (lu.se)
ABSTRACT The value of serum tumour markers in the prognosis of patients with breast cancer is controversial. (who.int)
Association of cyclin D1, p16 and retinoblastoma protein expressions with prognosis and metastasis of gallbladder carcinoma. (cdc.gov)

Signaling molecules released by the cancer cells drive both processes and thereby increase the malignancy of tumors. (scitechdaily.com)
The presence of high levels of a particular protein in tumors drives metastasis, providing a valuable biomarker for predicting the spread of cancer. (oncologynurseadvisor.com)
However, the team helped shed light on this process by finding that the carboxypeptidase E gene is alternatively spliced in human tumors to yield an N-terminal truncated protein that drives metastasis. (oncologynurseadvisor.com)
By measuring the protein's genetic material in human tumors and the genetic material from surrounding tissue, the investigators could predict at least 90% of the time whether a cancer would spread within 2 years, regardless of cancer stage. (oncologynurseadvisor.com)
The most dangerous aspect of breast cancer is its ability to spread to distant sites, and most tumors are initially unable to do that," says Andrew Ewald, Ph.D., assistant professor of cell biology at the Johns Hopkins School of Medicine and member of the Institute for Basic Biomedical Sciences' Center for Cell Dynamics. (bioquicknews.com)
Protein 4.1B is a 4.1/ezrin/radixin/moesin domain-containing protein whose expression is frequently lost in a variety of human tumors, including meningiomas, non-small-cell lung cancers, and breast carcinomas. (umn.edu)
Tumor necroptosis often happens in advanced solid tumors, and blocking necroptosis by MLKL deletion in breast cancer dramatically reduces tumor metastasis. (biomedcentral.com)
Interestingly, the levels of some soluble cell surface proteins including sE-cadherin that are known to promote metastasis are also dramatically reduced in MLKL null tumors/mice. (biomedcentral.com)
Administration of ADAMs pan inhibitor reduces the levels of soluble cell surface proteins in WT tumors/mice and leads to the dramatic decrease in metastasis. (biomedcentral.com)
Dr. Brody, Charles Yeo, M.D., Samuel D. Gross Professor and chair of Surgery at Jefferson Medical College and their co-workers analyzed IDO expression in 14 lymph nodes to which pancreatic cancer cells had spread and compared them to the primary tumors that had not spread in the same patients. (sciencedaily.com)
SRC-2 was highly elevated in a variety of tumors, especially in prostate cancer, in which SRC-2 was amplified and overexpressed in 37% of the metastatic tumors evaluated. (jci.org)
Metabolic profiling of human prostate tumors identified a massive increase in the SRC-2-driven metabolic signature in metastatic tumors compared with that seen in localized tumors, further implicating SRC-2 as a prominent metabolic coordinator of cancer metastasis. (jci.org)
Wieschaus discovered that cancer can co-opt this pathway, essentially corrupting its ability to grow as rapidly as embryos must, to grow tumors. (princeton.edu)
LRRC15 was expressed on stromal fibroblasts in many solid tumors (e.g., breast, head and neck, lung, pancreatic) as well as directly on a subset of cancer cells of mesenchymal origin (e.g., sarcoma, melanoma, glioblastoma). (aacrjournals.org)
However, researchers believe that statin-like drugs could be effective in treating breast cancer patients whose tumors have a high expression of Arf6. (pharmacytimes.com)
We report protease-resistant prion protein (PrP res ) in spontaneous lymphoreticular tumors of mice infected with the agent of variant Creutzfeldt-Jakob disease (vCJD). (cdc.gov)

This subsequently induces cancer cell growth, proliferation and metastasis. (amrita.edu)
Roles of circ-CSPP1 on the proliferation and metastasis of glioma cancer. (nih.gov)
Previous studies have reported that LINC00673 can promote epithelial-mesenchymal transition (EMT), proliferation and metastasis in thyroid carcinoma [ 5 ] . (jcancer.org)

These mutations were confirmed in patient lung metastases (n = 53) and were statistically associated with shorter median time to pulmonary metastasis. (nih.gov)
Two cases showed strong uniform expression of CAIX and HIF1α in the primary tumour as well as in the lymph node metastases, and sequencing revealed mutations in the coding regions of the Von-Hippel-Lindau gene (VHL). (ox.ac.uk)
Scope includes mutations and abnormal protein expression. (cancerindex.org)
Cancer cell-extrinsic mechanisms, which are poorly understood, are also believed to contribute to disease progression and the heterogeneous genetic mutations with diverse presentations. (nature.com)
Discriminating driver mutations from the ones that play no role in cancer is a severe bottleneck in elucidating molecular mechanisms underlying cancer development. (biomedcentral.com)
Since protein domains are representatives of functional regions within proteins, mutations on them may disturb the protein functionality. (biomedcentral.com)
This article presents a comprehensive study to map mutations from 29 cancer types to both sequence- and structure-based domains. (biomedcentral.com)
Only some of the mutations in coding regions, and not all of them lead to cancer. (biomedcentral.com)
Therefore, distinguishing mutations with drastic impacts on protein functionality may help discriminate driver mutations from less significant ones. (biomedcentral.com)
To this aim, some efforts have been made to study cancer mutations at the protein domain level. (biomedcentral.com)
12 ] mapped non-synonymous somatic mutations of Breast Invasive Carcinoma and Colon Adenocarcinoma Tumor samples to their corresponding protein domains, in order to extract domains with significant mutation frequency. (biomedcentral.com)
But the genetic mutations that caused the cancer in the first place can survive in a specific group of cells of the colon. (sciencedaily.com)
After cancer treatment ends, the surviving stem cells, still containing the cancerous mutations, can reappear and cause a relapse. (sciencedaily.com)
Almost all of the ASPM gene mutations responsible for MCPH reduce production of the ASPM protein. (medlineplus.gov)
Because the ASPM protein is found in cells throughout the body, it is unclear why ASPM gene mutations affect neural progenitor cells more severely than other cell types. (medlineplus.gov)
Protein-truncating mutations in ASPM cause variable reduction in brain size. (medlineplus.gov)
In these people, the reason why they develop lung cancer is unknown, but certain genetic mutations may be responsible. (msdmanuals.com)

But researchers have also found a causal connection between overexpression of MDMX and MDM2 and breast cancer. (cuny.edu)
Finally, we showed that USP19 overexpression is a surrogate prognostic marker of distant relapse in patients with early breast cancer. (nature.com)
This conundrum brings to question whether cancer ST6GAL1 overexpression is beneficial or ultimately detrimental to long-term patient outcomes and highlights the incomplete mechanistic understanding of how ST6GAL1 is involved in cancer progression. (nature.com)
Interestingly, while KLF6-SV1 overexpression increased metastasis, it did not affect localized tumor growth. (jci.org)
LINC00673 Overexpression is associated with good survival in pancreatic cancer patients, Effects of LINC00673 on pancreatic cancer cell apoptosis, viability, migration. (jcancer.org)
LINC00673 negatively correlated with miR-504 and MiR-504 overexpression promoted cancer progression in Pancreatic cancer. (jcancer.org)
IL-33 overexpression in gallbladder cancers associated with pancreatobiliary maljunction. (cdc.gov)

UCN-01, a protein kinase C (PKC) inhibitor, induces growth arrest and apoptosis in cancer cells and was recently introduced in a phase I clinical trial. (karger.com)
More than 15 years ago, cholesterol decrement was first shown to inhibit tumor cell growth, metastasis of tumor cells, and induction of apoptosis (7). (cdc.gov)
These pro- has been implicated as contributing apoptosis, inflammation, and several liferating cel s replace dead cel s to the cancer phenotype, through pleiotropic responses. (who.int)

Its mortality rate is mainly driven by metastatic breast cancer , which is still generally incurable . (medscape.com)
Advances in knowledge about AKT signaling may potentially lead to future novel treatment options for patients with advanced or metastatic breast cancer. (medscape.com)
How much do you know about AKT in advanced and metastatic breast cancer? (medscape.com)
The results from this prevali- the field of cancer biomarkers (11-13), and that approach was dation study showed that patients could be classified into high- adopted here to define predictive serum biomarkers associated versus low-risk groups for developing metastatic breast cancer with tumor relapse in breast cancer patients. (lu.se)
CA 15-3 levels are most commonly used to monitor metastatic breast cancer during active therapy. (medscape.com)
CA 15-3 measurement can also be used to survey disease recurrence after treatment of metastatic breast cancer. (medscape.com)
The highest levels may be seen in metastatic breast cancer, particularly when metastases to the liver or bones exist. (medscape.com)
Thus, normal levels do not ensure the absence of localized or metastatic breast cancer. (medscape.com)

They call for more studies to explore this "potentially powerful biomarker for predicting future metastasis and recurrence. (oncologynurseadvisor.com)
However, studies suggest that unusually high activity of the ASPM gene is related to cancer progression, spread to other parts of the body (metastasis), and recurrence. (medlineplus.gov)
This predict the likelihood of a later recurrence, i.e., an indicator that unique longitudinal sample material was collected from each pa- allows risk assessment for breast cancer metastasis, would be tient between 0 and 36 mo after the primary operation. (lu.se)
Cancer antigen 15-3 (CA 15-3) is used to monitor response to breast cancer treatment and disease recurrence. (medscape.com)
sis in primary breast cancer patients, toms of metastasis or recurrence and Tumour markers assays with elevated levels reflecting adverse with no other malignant disorders. (who.int)

Mechanisms governing metastasis-a major cause of mortality in cancer patients-remain elusive, noted Y. Peng Loh of the Eunice Kennedy Shriver National Institute of Child Health and Human Development, and fellow researchers in their online report of their protein discovery ( The Journal of Clinical Investigation , www.jci.org/articles/view/40433/pdf ). (oncologynurseadvisor.com)
Hence, further studies are required to unravel the molecular mechanisms of metastasis - governed by the establishment and release of cancer associated EVs. (springer.com)
SW480 and SW620 are two colon cancer cell lines established from the same patient with different metastatic potentials, making them an ideal model for investigation of metastatic mechanisms. (nih.gov)
In conclusion we observed unique histone modifications in two colon cancer cell lines with different metastatic potentials, indicating possible mechanisms for the down-regulation of NDRG1 in metastatic SW620. (nih.gov)
Given the intricate and expanding roles played by proteins in human health and disease, these have been studied extensively to uncover disease mechanisms, define diagnostic, prognostic and theranostic markers and identify novel therapeutic targets. (edu.au)
However, not much is known about specific molecular mechanisms underpinning NSCLC metastasis. (biomedcentral.com)
Although the function of NAP1 is associated with the invasive potentials of cancers and therefore their aggressive nature, there is lack of preclinical evidence and mechanisms reporting the importance of NAP1 during the metastasis and progression of NSCLC. (biomedcentral.com)
To evaluate the mechanisms underlying the role of AXL signalling in tumour metastasis, we screened a phage display library to generate a novel human monoclonal antibody, named DAXL-88, that recognizes both human and murine AXL. (cancerindex.org)
We explored the possible mechanisms underlying the anticancer activity of adenine in colorectal cancer cells. (hindawi.com)
A vast amount of research exists on the possible molecular mechanisms through which vitamin D affects cancer cell proliferation, cancer progression, angiogenesis, and inflammation. (mdpi.com)
These very close relationships, among very diverse research areas, allow us to bring in technologies from many different angles, and allow breakthroughs to understanding the mechanisms of metabolism in cancer - its progression, metastasis and the immune response - and also come up with new ways to target it. (princeton.edu)
However, the underlying mechanisms leading to pancreatic cancer are unclear. (jcancer.org)
Mark L., Lee W. H., Villoutreix B. O., Proctor D., Blackbourn, D., Spiller B. O. and Blom A. M. (2004) KSHV complement control protein mimics human molecular mechanisms for inhibition of the complement system. (lu.se)

These findings demonstrate the availability of a new route for therapeutic intervention in the inhibition of cancer dissemination. (springer.com)
Hence, the inhibition of EMT is now considered a promising strategy for stopping cancer metastasis. (naturalnews.com)
Moreover, SRC-2 inhibition in murine models severely attenuated the survival, growth, and metastasis of prostate cancer. (jci.org)
inhibition of angiogenesis is a promising new approach in cancer therapy. (karger.com)
Inhibition of HMG-CoA reductase by statin in effect prevents the synthesis of mevalonic acid, a precursor of nonsteroidal isoprenoids, lipid attachment molecules for small G proteins, such as Ras, Rho, and Rac. (cdc.gov)
Different strategies to target hypoxic cancer cells and/or HIFs include hypoxia-activated prodrugs and inhibition of HIF dimerization, mRNA or protein expression, DNA binding capacity, and transcriptional activity. (lu.se)
MicroRNAs (miRNAs) are small, noncoding RNAs that bind to the 3' UTR of target mRNAs, and silence gene expression by inducing degradation of target mRNAs or inhibition of protein translation [ 10 ]. (cdc.gov)

Since hypoxia activates hypoxia-inducible factor (HIF-1)-dependent transcription in cancer cells that, in a paracrine fashion, drive tumor angiogenesis, we investigated the effects of UCN-01 on HIF-1-responsive promoter constructs. (karger.com)
2008. NVP-AUY922: a novel heat shock protein 90 inhibitor active against xenograft tumor growth, angiogenesis, and metastasis . (ub.edu)

CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. (rndsystems.com)
In addition, you will have the opportunity to learn microbiologic and immunologic techniques and to express and purify recombinant proteins. (lu.se)

Caption: The MDMX and MDM2 proteins promote metastasis in triple-negative breast cancer, while the MDM2 protein promotes tumor growth in estrogen receptor a-positive breast cancer. (cuny.edu)

Construction of prognostic risk score model of colorectal cancer gene signature based on transcriptome dysregulation [J]. JOURNAL OF SHANGHAI JIAOTONG UNIVERSITY (MEDICAL SCIENCE), 2021, 41(3): 285-296. (shsmu.edu.cn)
Establishment and validation of prognostic prediction model of colorectal cancer based on single-cell RNA sequencing [J]. JOURNAL OF SHANGHAI JIAOTONG UNIVERSITY (MEDICAL SCIENCE), 2021, 41(2): 159-165. (shsmu.edu.cn)
Role of uPAR in colorectal cancer -- 4. (edu.au)
Antagonism of metastasis in late-stage colorectal cancer (CRC) -- 5. (edu.au)
Colorectal cancer (CRC) is one of the leading malignancies, which is expected to account for 2.2 million new cases and 1.1 million deaths worldwide in 2030 [ 1 ]. (hindawi.com)
Although these therapeutic regimens achieve somewhat satisfactory local disease control, effective regimens for metastatic CRC patients with liver metastases from colorectal cancer are limited. (hindawi.com)
It is of interest to explore the inhibitory effect of adenine on the growth of colorectal cancer cells and to determine the underlying mechanism. (hindawi.com)
The present study aimed to investigate components other than phenolic compounds that may have antitumor effects against colorectal cancer (CRC). (spandidos-publications.com)
Statins have been associated with a significantly lower risk of breast (8), colorectal (9), and lymph cancers (10-12) in several observational studies (10,13). (cdc.gov)
A total of 2226 deter- or regression status in breast cancer cological (lung, colorectal, pancreas minations of serum CEA and CA15-3 patients [5-8]. (who.int)

Results For EGFR+/ER- breast cancer, the overall survival of patients with high expression of MTA3 in cancer tissues was longer (67.9% and 41.2%, P=0.059). (shsmu.edu.cn)
For EGFR-/ER+ breast cancer, the overall survival of patients with low expression of MTA3 in cancer tissues was longer (100.0% and 72.0%, P=0.039). (shsmu.edu.cn)
This observation was confirmed in vitro as COMP-expressing cells showed better survival as well as a higher rate of protein synthesis when treated with brefeldin A, compared with control cells. (lu.se)
Nck-associated protein 1 (NAP1/NCKAP1) is highly expressed in primary non-small-cell lung cancer (NSCLC) when compared with adjacent normal lung tissues, and its expression levels are strongly associated with the histologic tumor grade, metastasis and poor survival rate of NSCLC patients. (biomedcentral.com)
Metabolic pathway reprogramming is a hallmark of cancer cell growth and survival and supports the anabolic and energetic demands of these rapidly dividing cells. (jci.org)
Here, we determined that upregulation of the oncogenic transcriptional coregulator steroid receptor coactivator 2 (SRC-2), also known as NCOA2, drives glutamine-dependent de novo lipogenesis, which supports tumor cell survival and eventual metastasis. (jci.org)
SRC-2 is essential for prostate cancer cell survival. (jci.org)
Aberrant expression and glycosylation of mucins contribute to tumour survival and proliferation in many cancers, which in turn activates numerous signalling pathways such as NF-kB, ERα, HIF, MAPK, p53, c-Src, Wnt and JAK-STAT, etc. (amrita.edu)
Kaplan-Meier analysis associated COMT and DSC1 with decreased overall survival in breast cancer subsets. (muni.cz)
Tumor cell dissemination in cancer patients is associated with a significant reduction in their survival and quality of life. (nature.com)
Bone metastases can cause a wide range of symptoms that could impair quality of life of lung cancer patients and shorten their survival. (hindawi.com)
Bone metastasis is a major determinant of treatment outcome, quality of life, and survival for lung cancer patients [ 12 - 14 ]. (hindawi.com)
Certainly, the presence of bone metastasis usually leads to worse outcome and shorter median survival [ 11 , 15 , 16 ]. (hindawi.com)
Although there are currently some available palliative treatment options for patients with bone metastases from any solid tumor origin such as radiation therapy and bone targeted/bone strengthening treatments (bisphosphonates and denosumab) that are used in clinical practice, none of them is specific for lung cancer metastases and they do not affect the poor survival outcome of this disease. (hindawi.com)
Survival from breast cancer has improved during the past dec- markerserumlevelshavebeenusedpreviously,e.g.,incalculating ades in the Western world. (lu.se)
For example, in breast cancer loss of WNT5A protein is associated with poor survival. (lu.se)
In contrast, WNT5A expression is associated with increased metastasis and reduced survival in melanoma patients. (lu.se)
The disparities in breast cancer incidence and survival between AA and EA populations have been attributed to several factors, including disease management, access to proper care, and biological influences. (cdc.gov)

Metastasis of cancer cells involves a process called epithelial-mesenchymal transition (EMT), wherein epithelial cells undergo phenotypic changes to resemble mesenchymal cells -- stem cells capable of turning into different types of adult cells. (naturalnews.com)
Recently, epithelial-mesenchymal transition (EMT) programs have become the focus of the mechanism of metastasis [ 1 , 17 - 20 ]. (intechopen.com)

Regions with high numbers of mutation for each cancer type were called hotspot. (biomedcentral.com)
This study represents a method to explore protein domains with significant mutation frequencies, using whole exome sequencing data. (biomedcentral.com)

However, the exact mechanism by which tumor necroptosis promotes tumor metastasis remains elusive. (biomedcentral.com)

MUC glycoproteins: Potential biomarkers and molecular targets for cancer therapy. (amrita.edu)
Home Publications MUC glycoproteins: Potential biomarkers and molecular targets for cancer therapy. (amrita.edu)
11 proteins were up-regulated and 17 proteins were down-regulated, while consistent presence/absence expression profile group contains one elevated protein and nine reduced proteins, among which seven proteins were identified as potential biomarkers for IVR treatment through PRM assays. (frontiersin.org)
Their superficial location on the cell makes them attractive biomarkers, that is, molecules that can be used to detect different types of cancer and other diseases. (lu.se)

Metastasis occurs when cancer cells break free from a primary tumor and spread throughout the body, requiring them to sever connections with neighboring cells and migrate to other tissues. (scitechdaily.com)
The dynamics of the actin-network enable the locomotion of cells, for example during development or wound closure, but also that of spreading cancer cells. (scitechdaily.com)
For their study, they used high-resolution microscopy to track the movement of individual transport vesicles within living cancer cells. (scitechdaily.com)
NEW YORK, January 30, 2019 - The MDMX and MDM2 proteins play critical roles in keeping the tumor-suppressing protein p53 from damaging the production of healthy cells. (cuny.edu)
A new study from Johns Hopkins researchers and colleagues suggests that the lethal spread of breast cancer is as dependent on a tumor's protein-rich environment as on genetic changes inside tumor cells. (bioquicknews.com)
In a report in the September 25, 2005 issue of PNAS, the scientists conclude that a molecular signal in the protein meshwork surrounding the breast cancer cells may provide the critical trigger to initiate the life-threatening process of metastasis to distant sites in the body. (bioquicknews.com)
Moreover, their experiments suggest that the environment surrounding a tumor can even coax healthy breast cells to invade surrounding tissue just as cancer cells do, and that a healthy environment can cause cancer cells to stay put and not spread as they usually do. (bioquicknews.com)
Down-regulation of 4.1B increased the metastatic propensity of poorly metastatic cells in an orthotopic model of prostate cancer. (umn.edu)
We previously described a gene signature for breast cancer stem cells (BCSCs) derived from patient biopsies. (nih.gov)
Cancer cells have proven efficient in educating fibroblasts, within their microenvironment, to secrete EVs as communicative vessels for mediating phenotypic changes in recipient cells. (springer.com)
Using this vesicular delivery system, cancer cells can establish a new metastatic niche within distant sites, away from the primary tumor, thus favoring cancer progression. (springer.com)
Tissue microarrays derived from two cohorts of patients with breast cancer (n=122 and n=498) were immunostained, revealing varying expression of COMP, both in the tumor cells and surrounding stroma. (lu.se)
Breast cancer cells, MDA-MB-231, stably expressing COMP were injected into the mammary fat pad of SCID (CB-17/Icr-Prkdc(scid)/Rj) mice. (lu.se)
EMT not only increases the motility of cancer cells, but it also makes them more invasive. (naturalnews.com)
The modern TCM formulation YGJDSJ is composed of different medicinal herbs, some of which have shown the ability to inhibit EMT in cancer cells in numerous experiments. (naturalnews.com)
Duchesnea indica (mock strawberry or she mei) -- A recent study reported that D. indica extracts could inhibit highly metastatic lung adenocarcinoma cells by down-regulating EMT-related proteins. (naturalnews.com)
Polygonum cuspidatum (Japanese knotweed or hu zhang) -- The anti-tumor and anti-metastatic properties of P. cuspidatum come from the ability of its active component, resveratrol, to stop DNA synthesis in cancer cells . (naturalnews.com)
To determine the effects of YGJDSJ on TGF- B 1-induced EMT, the researchers tested the formula on Bel-7402 liver cancer cells. (naturalnews.com)
Based on these findings, the researchers concluded that YGJDSJ could inhibit TGF- B 1-induced EMT and mediates the metastatic potential of liver cancer cells by down-regulating Smad3 phosphorylation and Snail expression. (naturalnews.com)
Nck-associated protein 1 (NAP1/NCKAP1), a protein that associates with the Src homology 3 (SH3) domain of NCK protein both in vitro and in intact cells, was found to localize along the lamellipodia and to mediate contact-dependent cell migration [ 4 ]. (biomedcentral.com)
Our previous studies further demonstrated that NAP1 is required for the protein stability of WASF3 in breast cancer cells, implicating that NAP1 is a critical regulator in favor of breast cancer metastasis [ 5 ]. (biomedcentral.com)
MLKL activation also leads to the protease, ADAMs-mediated ectodomain shedding of cell surface proteins of necroptotic cells. (biomedcentral.com)
Here, we report that the ectodomain shedding of cell surface proteins of necroptotic cells is critical for the promoting effect of tumor necroptosis in tumor metastasis through inhibiting the anti-tumor activity of T cells. (biomedcentral.com)
We found that blocking tumor necroptosis by MLKL deletion led to the dramatic reduction of tumor metastasis and significantly elevated anti-tumor activity of tumor-infiltrating and peripheral blood T cells. (biomedcentral.com)
Importantly, the increased anti-tumor activity of T cells is a key cause for the reduced metastasis as the depletion of CD8+ T cells completely restored the level of metastasis in the Mlkl KO mice. (biomedcentral.com)
Finally, we showed the sE-cadherin/KLRG1 inhibitory receptor is the major pathway for necroptosis-mediated suppression of the anti-tumor activity of T cells and the promotion of metastasis. (biomedcentral.com)
A protein that helps prevent a woman's body from rejecting a fetus may also play an important role in enabling pancreatic cancer cells to evade detection by the immune system, allowing them to spread in the body. (sciencedaily.com)
Researchers found that the metastatic pancreatic cancer cells in the lymph nodes produce enough of the protein, IDO, to wall-off the immune system's T-cells and recruit cells that suppress the immune response to the tumor. (sciencedaily.com)
According to Jonathan Brody, Ph.D., assistant professor of Surgery at Jefferson Medical College of Thomas Jefferson University, one way that metastatic cancer cells can survive in nearby lymph nodes is by avoiding the immune system. (sciencedaily.com)
The Jefferson scientists wanted to know if metastatic pancreatic cancer cells residing in the lymph nodes expressed IDO to avoid being found, and if so, could they target this enzyme with available drugs to prevent the cancer cells from hiding from the immune system. (sciencedaily.com)
These data point to the fact that IDO may play a role in helping cancer cells avoid the immune system. (sciencedaily.com)
The immune system appears to have a balance that can allow cancer cells to grow but also can detect and destroy them, Brody explains. (sciencedaily.com)
An inhibitor might be able to activate T-cells to kill cancer cells, for example. (sciencedaily.com)
In the present study, we investigated the anticancer effects of adenine and the underlying mechanism in colon cancer cells. (hindawi.com)
Adenine significantly inhibited the viability of colon cancer cells, HT29 and Caco-2 cells, in a dose-dependent manner. (hindawi.com)
Our findings suggest that adenine inhibits the growth of colon cancer cells. (hindawi.com)
Anticancer activity of adenine in colon cancer cells is attributable to the activation of apoptotic signaling and in turn the AMPK/mTOR pathway. (hindawi.com)
Adenine has been suggested to induce cell cycle arrest in cancer cells, leading to cell death [ 9 , 10 ]. (hindawi.com)
However, the mechanism by which adenine inhibits the proliferation of cancer cells is sketchy. (hindawi.com)
In this study, we investigated the effects of adenine against the proliferation of colon cancer cells. (hindawi.com)
In prostate cancer cells, SRC-2 stimulated reductive carboxylation of α-ketoglutarate to generate citrate via retrograde TCA cycling, promoting lipogenesis and reprogramming of glutamine metabolism. (jci.org)
D ) Quantification of Ki67-stained cells (antibody epitope reacts with human Ki67 protein) in mouse lung sections from shNT-, sh18-, and sh19-injected animals. (jci.org)
The ubiquitination pathway plays a fundamental role in the maintenance of protein homeostasis both in normal and stressed conditions and its dysregulation has been associated with malignant transformation and invasive potential of tumor cells, thus highlighting its value as a potential therapeutic target. (nature.com)
We demonstrate that UCN-01, at concentrations lower than those necessary to inhibit cancer cell growth, inhibit proliferation of human endothelial cells in vitro. (karger.com)
We conclude that UCN-01, at clinically relevant concentrations, exerts an anti-neovascularization effect by blocking two important steps in vessel formation: (1) the response of cancer cells to hypoxia, and (2) endothelial cell proliferation. (karger.com)
This 3D image of human breast cancer bone metastases shows the formation of the newly described organelle (magenta) in cancer cells (cyan). (princeton.edu)
Cell nuclei from both cancer cells and normal bone cells are labeled in blue. (princeton.edu)
immunotherapeutics being a prime example of the latter) with the potential to eliminate all cancer cells, despite their clonal heterogeneity and their surrounding microenvironment. (nih.gov)
Cancer cells depart their normal microenvironment from the primary tumor site through complicated and multistep processes disseminate and colonize distant organs [ 1 ]. (intechopen.com)
Cancer refers to a group of diseases characterized by uncontrolled growth and division of cells in the body, and is caused by environmental as well as genetic factors. (biomedcentral.com)
Castro-Puyana M, Pérez-Sánchez A, Valdés A, Ibrahim OHM, Suarez-Álvarez S, Ferragut JA, Micol V, Cifuentes A, Ibáñez E and García-Cañas V: Pressurized liquid extraction of Neochloris oleoabundans for the recovery of bioactive carotenoids with anti-proliferative activity against human colon cancer cells. (spandidos-publications.com)
There are many reasons for this, but one has to do with a group of persisting cancer cells in the colon that cause relapses. (sciencedaily.com)
The approach activates a protein that is lost in the persisting cancer cells. (sciencedaily.com)
The researchers were able to reactivate it using vitamin A, thus eliminating the cancer cells and preventing metastasis. (sciencedaily.com)
When a colon-cancer patient receives treatment, e.g. chemotherapy, most of the cancer cells die off. (sciencedaily.com)
In the adult body, proteins like HOXA5 regulate the body's stem cells to maintain both the identity and function of different tissues. (sciencedaily.com)
By blocking the HOXA5 gene, the cancerous stem cells of the colon can grow uncontrollably and spread, causing relapses and metastasis. (sciencedaily.com)
By turning the gene for HOXA5 back on, this treatment eliminated cancer stem cells and prevented metastasis in the live animals. (sciencedaily.com)
The "cargo carriers," or endosomes, of certain brain cancer cells contain overactive NHE9 proteins (blue), which pump out too many protons (orange), changing the endosomes' acidity and slowing their "shipping speed. (medicaldaily.com)
Additionally, the Arf6 pathway could promote drug resistance in breast cancer cells. (pharmacytimes.com)
Blocking the MVP might effectively kill cancer cells that overexpress the Arf6 pathway, especially in combination with other drugs," said lead researcher Hisataka Sabe. (pharmacytimes.com)
HNF1A inhibited cell progression in pancreatic cancer cells. (jcancer.org)
A human Pancreatic duct epithelial cells line (HPDE), HEK-293T and three human pancreatic cancer cell lines (CanPan-1, Hs-766T, CFPAC-1) were obtained from Chinese typical culture preservation center. (jcancer.org)
Studies suggest that the ASPM protein helps maintain the orderly division of early brain cells called neural progenitor cells, which ultimately give rise to mature nerve cells (neurons). (medlineplus.gov)
By promoting the division of neural progenitor cells during early brain development, the ASPM protein helps determine the total number of neurons and the overall size of the brain. (medlineplus.gov)
A shortage of functional ASPM protein impairs cell division, especially in neural progenitor cells in the developing brain. (medlineplus.gov)
Some researchers believe that neural progenitor cells are more sensitive than other types of cells to a shortage of the ASPM protein. (medlineplus.gov)
Other researchers have suggested that another protein may be able to compensate for the loss of the ASPM protein in cells outside the brain. (medlineplus.gov)
The ASPM gene is upregulated in several types of cancer, which means that it produces more of the ASPM protein than usual in cancer cells. (medlineplus.gov)
It is unclear why the ASPM gene is abnormally active in these cancers or what effects the extra ASPM protein may have in cancer cells. (medlineplus.gov)
Induction of cancer-associated fibroblast-like cells by carbon nanotube s dictates its tumorigenicity. (cdc.gov)
The mechanism by which CNT-induced CAF-like cells promote tumor growth involved the acquisition of cancer stem cells (CSCs) in cancer population. (cdc.gov)
Primary lung cancer is cancer that originates from lung cells. (msdmanuals.com)
The CA 15-3 antigen (also known as MUC1, from which it is derived) represents sequences of mucins that are often overexpressed in malignant glandular cells, such as breast cancer. (medscape.com)
2019) Cartilage Oligomeric Matrix Protein initiates cancer stem cells through activation of Jagged1-Notch3 signaling. (lu.se)
Trouw L., Nilsson S., Goncalvez I., Landberg G. and Blom A. M. (2005) C4b-binding protein binds to necrotic cells and DNA, which limits DNA release and inhibits complement activation. (lu.se)
TRANSPORT PROTEINS can be found on the surface of all human cells. (lu.se)
We studied cell samples from 25 different types of tumours as well as the corresponding normal tissue to see how the expression of transport proteins differs between healthy and diseased cells. (lu.se)
A weak radioactive substance that binds specifically to the cells where the protein is expressed is already applied to diagnose certain diseases in which neural tissue is broken down. (lu.se)
Because the transport proteins exist on the surface of the cancer cells in the kidney, the same substance can be used to find them. (lu.se)

Protein levels were assessed by Western blotting and immunohistochemistry. (biomedcentral.com)

Knockdown of RPL39 and MLF2 by specific siRNA nanoparticles in patient-derived and human cancer xenografts reduced tumor volume and lung metastases with a concomitant decrease in BCSCs. (nih.gov)
Metastatic lung cancer is a life-threatening condition that develops when cancer in another area of the body metastasizes, or spreads, to the lung. (biomedcentral.com)
Despite advances in our understanding of primary lung oncogenesis, the biological basis driving the progression from primary to metastatic lung cancer remains poorly characterized. (biomedcentral.com)
Non-small-cell lung cancer (NSCLC) accounts for 85%-90% of all lung cancer cases, and is the most common cause of cancer-related deaths worldwide [ 1 ]. (biomedcentral.com)
C ) H&E-stained sections of mouse lungs from experimental lung metastasis assay. (jci.org)
Despite advances in diagnosis and treatment, the morbidity and mortality of lung cancer remains to mount up. (intechopen.com)
Lung cancer is the second most common cancer and the leading cause of cancer related mortality in both men and women. (hindawi.com)
Each year, more people die of lung cancer than of colon, breast, and prostate cancers combined. (hindawi.com)
It is widely accepted that tumor metastasis is a formidable barrier to effective treatment of lung cancer. (hindawi.com)
The bone is one of the frequent metastatic sites for lung cancer occurring in a large number of patients. (hindawi.com)
We strongly believe that molecular targets (tumor-related and bone microenvironment based) that have been implicated in lung cancer bone metastases hold great promise in lung cancer therapeutics. (hindawi.com)
It is anticipated that the information gathered might be useful in future efforts of optimizing lung cancer treatment strategies. (hindawi.com)
Lung cancer is a significant public health burden in the USA. (hindawi.com)
It is estimated that, in 2014, there will be approximately 224,000 newly diagnosed cases of lung cancer and 159,000 deaths from lung cancer [ 1 ]. (hindawi.com)
There are two main subcategories of lung cancer: nonsmall cell lung cancer (NSCLC) and small cell lung cancer (SCLC). (hindawi.com)
It is generally believed that the high mortality rate of lung cancer cases may be a result of the aggressiveness and invasive and metastatic potential of the disease and the fact that it is not easily detectable until it reaches advanced stages [ 2 ]. (hindawi.com)
In fact, over two-thirds of lung cancer patients have regional lymph-node involvement or distant metastases at the time of presentation [ 3 ]. (hindawi.com)
The bone is one of the most common metastatic sites for lung cancer [ 8 , 9 ]. (hindawi.com)
Involvement of bone in lung cancer metastases is a major source of morbidity and mortality arising from skeletal related events (SREs) [ 10 ]. (hindawi.com)
This underscores the need to assess molecular targets that can be exploited in prevention or clinical management of lung cancer metastases to bone. (hindawi.com)
Thus, in this report, we will assess the data on lung cancer bone metastases with the intention of evaluating key molecular targets that could be applied in optimizing lung cancer treatment strategies. (hindawi.com)
Chest x-rays can detect most lung cancers, but other additional imaging tests and biopsies are needed to confirm the diagnosis. (msdmanuals.com)
In 2022, the American Cancer Society estimated that 236,740 new cases of lung cancer will be diagnosed in the United States (118,830 in women and 117,910 in men), and 130,180 people will die from the disease. (msdmanuals.com)
The incidence of lung cancer has been declining in men over the past 3 decades and has started to decline in women. (msdmanuals.com)
Primary lung cancer can start in the airways that branch off the trachea to supply the lungs (the bronchi) or in the small air sacs of the lung (the alveoli). (msdmanuals.com)
About 85% of lung cancers are in this category. (msdmanuals.com)
This cancer grows more slowly than small cell lung cancer. (msdmanuals.com)
The most common types of non-small cell lung cancer are squamous cell carcinoma, adenocarcinoma, and large cell carcinoma. (msdmanuals.com)
Sometimes called oat cell carcinoma, this cancer accounts for about 15% of all lung cancers. (msdmanuals.com)
Cigarette smoking is the leading cause of lung cancer, accounting for about 85% of all lung cancer cases. (msdmanuals.com)
The risk of developing lung cancer varies by both the number of cigarettes smoked and the number of years of smoking. (msdmanuals.com)
Still, some heavy smokers do not develop lung cancer. (msdmanuals.com)
In people who quit smoking, the risk of developing lung cancer decreases, but former smokers continue to have a higher risk of developing lung cancer than people who never smoked. (msdmanuals.com)
About 15 to 20% of people who develop lung cancer have never smoked or have smoked only minimally. (msdmanuals.com)
The risk of contracting lung cancer is greater in people who are exposed to these substances and who also smoke cigarettes. (msdmanuals.com)
The risk of lung cancer related to electronic nicotine delivery systems such as e-cigarettes remains to be determined, although doctors think that the substances created by burning tobacco are more likely to be the cause of cancer than nicotine itself. (msdmanuals.com)
It is unknown whether marijuana smoking increases the risk of lung cancer. (msdmanuals.com)

Princeton cancer researchers Yibin Kang (left) and Mark Esposito, seen here in April 2019, discovered a new, still-unnamed organelle that plays a role in bone metastasis and is formed via liquid-liquid phase separation - when liquid blobs of living materials merge into each other. (princeton.edu)

Our findings suggest that despite of the fact that MTCs have only slowly growth, tumour hypoxia plays an important role in the development of loco-regional metastases. (ox.ac.uk)
This prospective study in Yazd, Islamic Republic of Iran, assessed the value of the tumour markers carcinoembryonic antigen (CEA) and cancer antigen (CA) 15-3 in 159 patients with primary breast cancer. (who.int)
Early diagnosis is critical as the disease can be cured by surgically removing the affected organ if detected while the cancer is still confined to the actual kidney", says Håkan Axelsson, Professor of Tumour Biology at Lund University and one of the founders of Akuru Pharma - a company trying to develop diagnostic methods and treatments for renal cancer. (lu.se)

Evidence of this process was seen in human metastatic colon, breast, liver, and head and neck cancer cell lines. (oncologynurseadvisor.com)
Liver cancer is one of the deadliest types of human cancer. (naturalnews.com)
Hepatocellular carcinoma (HCC), which often occurs in patients with already existing liver disease, is considered the most common form of liver cancer. (naturalnews.com)
The researchers found that YGJDSJ can decrease the expression of proteins important for metastasis , making it a promising natural medicine for metastatic liver cancer. (naturalnews.com)
These activities may be used for the prevention of liver cancer metastasis . (naturalnews.com)
Imaging studies in- was one of the first serum-based tu- The study sample was women with cluding chest X-rays, liver ultrasonog- mour markers to be characterized, primary breast cancer attending a pri- raphy and bone scans were performed and its utility has been assessed in vate clinic in Yazd, Islamic Republic if there was clinical or laboratory a variety of malignancies including of Iran. (who.int)

N-Myc downstream-regulated gene 1 (NDRG1) plays vital roles in tumor metastasis suppression and is frequently silenced in metastatic colon cancers. (nih.gov)
TAM family members (TYRO3, AXL and MERTK) play essential roles in the resolution of inflammation and in infectious diseases and cancer. (cancerindex.org)
microRNAs are a class of noncoding RNAs that play important roles in cancer progression. (cancerindex.org)
Subsequent research has revealed that the Wnt signaling pathway plays multiple roles in healthy bone growth as well as in cancer metastasizing to bones. (princeton.edu)
Unlocking the Mysteries of the Immune System: new Roles of complement proteins in Diabetes and Cancer. (lu.se)

In mice that had colon cancer, the treatment with retinoids blocked tumor progression and normalized the tissue. (sciencedaily.com)

Desmoplastic stroma reaction is a strong risk factor associated with lymph node metastases. (ox.ac.uk)

Research progress in the systemic treatment for breast cancer with brain metastasis [J]. JOURNAL OF SHANGHAI JIAOTONG UNIVERSITY (MEDICAL SCIENCE), 2021, 41(5): 671-677. (shsmu.edu.cn)
Expression of breast cancer susceptibility gene 1 protein in brain gliomas and its influence on the sensitivity of temozolomide [J]. JOURNAL OF SHANGHAI JIAOTONG UNIVERSITY (MEDICAL SCIENCE), 2021, 41(1): 118-122. (shsmu.edu.cn)
BMC cancer 2021 11 21 (1): 1245. (cdc.gov)

An experimental mouse model was generated to investigate the gene regulation in tumor growth and metastasis. (biomedcentral.com)

Learning more specifically what triggers metastases may provide additional targets for preventing and treating the malignant process that causes cancer deaths, Dr. Ewald adds. (bioquicknews.com)
however, these factors have potential as cancer therapy targets. (jci.org)
Biological treatment of many cancers currently targets membrane bound receptors located on a cell surface. (muni.cz)
We believe that these molecular targets could guide in determining timing of therapeutic interventions that offer the best opportunity to prevent and/or halt extent of bone metastases. (hindawi.com)

Tumor microenvironment has been recognized as a key determinant of tumor formation and metastasis, but how tumor microenvironment is affected by nanomaterial s is essentially unknown. (cdc.gov)
Here, we investigated whether carbon nanotube s (CNTs), a widely used nanomaterial with known carcinogenic potential, can affect cancer-associated fibroblasts (CAFs), which are a key component of tumor microenvironment that provides necessary support for tumor growth. (cdc.gov)

Vascular endothelial growth factor single-nucleotide polymorphism in gallbladder cancer. (cdc.gov)

In a secondary experiment, the researchers also looked at the relationship between MDM2 and tumor growth in estrogen receptor positive breast cancer. (cuny.edu)
Methods Tissue microarrays were made using 160 breast cancer samples and contained epidermal growth factor receptor (EGFR) data, estrogen receptor (ER) data, and follow-up information. (shsmu.edu.cn)
Euphorbia helioscopia (madwoman's milk or ze qi) -- Like L. lucidum , E. helioscopia can stop tumor growth , induce cell death, and inhibit the metastasis of HCC in vivo. (naturalnews.com)
Transcription growth factor-beta 1 (TGF- B 1) is a protein involved in many cellular functions. (naturalnews.com)
It transduces signals from the extracellular matrix into the cytoplasm by binding to the vitamin K-dependent protein growth arrest-specific 6 (Gas6). (cancerindex.org)
While scientists know a great deal about how a pancreatic cancer develops from a pre-cancerous growth into a cancer, they still don't have a clear understanding of how it progresses from a primary cancer to metastatic disease. (sciencedaily.com)
While IDO is crucial to regulating this balance, too much IDO tips the balance toward an immune suppression, supporting cancer growth. (sciencedaily.com)
It regulates tumor growth and various processes leading to breast cancer metastasis. (medscape.com)
We report that, in addition to direct inhibitory effects on endothelial cell growth, UCN-01 abrogates hypoxia-mediated transactivation of HIF-1-responsive promoters in a prostate cancer cell line. (karger.com)
To compare the differences of vitreous protein profiles in PDR patients before and after a complete anti-vascular endothelial growth factor (VEGF) loading dose with ranibizumab treatment. (frontiersin.org)
Now the biological pathway behind the growth of colon cancer has been discovered by researchers who have been able block it with vitamin A. (sciencedaily.com)

Progress in understanding tumor stromal biology has been constrained in part because cancer-associated fibroblasts (CAF) are a heterogeneous population with limited cell-type-specific protein markers. (aacrjournals.org)

These studies are very expensive, but our next goal would be to test one of the small molecules known to block MDMX to see if it can inhibit metastases," she said. (cuny.edu)
Thus, statins may inhibit the synthesis of isoprenoids and thereby suppress the activation of small G proteins (7). (cdc.gov)

Its therapeutic use for managing cancer is of great interest. (hindawi.com)
Together, these results suggest that the SRC-2 pathway has potential as a therapeutic target for prostate cancer. (jci.org)
MUC proteins have great significance as prognostic and diagnostic markers as well as a potential target for therapeutic interventions in most cancers of glandular epithelial origin. (amrita.edu)
HX-MS can be used to study a wide range of structural properties including protein folding, ligand binding and allostery, and epitope mapping in the development of therapeutic antibodies. (diwou.com)
In order to resist cancer dissemination, more effective therapeutic strategies are clearly required. (intechopen.com)
Dutta S, Mahalanobish S, Saha S, Ghosh S and Sil PC: Natural products: An upcoming therapeutic approach to cancer. (spandidos-publications.com)
On therapeutic front, we have developed a hexapeptide, Foxy5 (an agonist of WNT5A) which is currently in Phase1 clinical trial for breast cancer, prostate cancer and colon carcinoma (NCT02020291). (lu.se)
Therefore, therapeutic targeting of HIFs in cancer has the potential to improve treatment efficacy. (lu.se)

The findings might mean not only a better way to detect pancreatic cancer spreading to lymph nodes, but also could enhance tumor immune therapy strategies against the fast-moving, deadly disease. (sciencedaily.com)
They also looked at three cases of lymph node-negative pancreatic cancers, finding little IDO present. (sciencedaily.com)
The group also examined pancreatic cancer cell lines in the laboratory for IDO expression. (sciencedaily.com)
Dr. Brody notes that IDO inhibitors are available clinically, and these could in theory be used with chemotherapy or perhaps other forms of immune therapy against pancreatic cancer. (sciencedaily.com)
Pancreatic cancer, the fourth-leading cause of cancer death in this country, takes some 33,000 lives a year. (sciencedaily.com)
Pancreatic cancer is a highly invasive malignant tumor of the digestive system. (jcancer.org)
We identified a LINC00673, which is highly correlated with the pancreatic cancer risk. (jcancer.org)
MiR-504 negatively correlated with HNF1A, which was highly expressed Pancreatic cancer. (jcancer.org)
showed that the rs7214041 gene site of LINC00673 is highly correlated with the incidence of pancreatic cancer [ 7 ] . (jcancer.org)
LINC00673 plays an important role in maintaining cellular homeostasis, and its germline variability affects pancreatic cancer susceptibility. (jcancer.org)
Additionally, we identified miR-504 as a target of LINC00673 in pancreatic cancer. (jcancer.org)
Our findings will help develop potential therapies for the treatment of pancreatic cancer metastasis. (jcancer.org)
We found very high levels of expression of the central complement protein, C3, and complement inhibitor CD59 in human pancreatic islets. (lu.se)
Polymorphisms of SPINK1 N34S and CFTR in patients with sporadic and familial pancreatic cancer. (cdc.gov)

For death-receptor-induced necroptosis, the protein kinase receptor-interacting protein kinase 1, 3 (RIPK1, RIPK3) and mixed lineage kinase domain-like protein (MLKL) are the key components of the necroptosis machinery [ 1 , 2 , 3 ]. (biomedcentral.com)
The protein encoded by this gene is a member of the Tyro3-Axl-Mer (TAM) receptor tyrosine kinase subfamily. (cancerindex.org)
AKT , also known as protein kinase B (PKB), belongs to the AGC family of protein kinases. (medscape.com)
The data showed that adenine activated AMP-activated protein kinase (AMPK) signaling contributing to autophagic cell death through mTOR in both colon cancer cell lines. (hindawi.com)
Involvement of AMP-activated protein kinase (AMPK) in anticancer property of adenine was also investigated. (hindawi.com)

We evaluated immunohistochemically the expression of two hypoxia-associated proteins, carbonic anhydrase IX (CAIX) and hypoxia-induced factor 1α (HIF1α), and ki-67, intercellular matrix adhesion molecule E-cadherin and the stroma remodelling marker tenascin C in a series of 100 sporadic MTCs and corresponding lymph node metastases, if present. (ox.ac.uk)
The absence of membranous E-cadherin staining was significantly associated with the grade of desmoplasia, tenascin expression and lymph node metastases (p≤0.05) but not with ki67 proliferation index or expression of hypoxia-associated factors. (ox.ac.uk)
Expression of hypoxia-associated proteins was in most cases identical between primary tumours and lymph node metastases. (ox.ac.uk)
In every case, they found greater expression of the IDO protein in the cancerous lymph nodes. (sciencedaily.com)
Presumably we could give IDO inhibitors up front to patients who we know are lymph node-positive to try to reduce the cancer and possibly convert them to surgical candidates," he explains. (sciencedaily.com)
To date, all tested vCJD patients have shown an accumulation of misfolded protease-resistant protein (PrP res ), a highly reliable indicator of infection, in lymphoreticular tissues such as spleen, tonsil, lymph nodes, and appendix ( 1 ). (cdc.gov)

Kask L., Hillarp A., Ramesh B., Dahlbäck B., and Blom A. M. (2002) Structural requirements for the intra-cellular subunit polymerization of the complement inhibitor C4b-binding protein. (lu.se)

SND1 acts as oncogene in many cancers and in hepatocellular carcinoma progression. (wikipedia.org)

Becker A, Thakur BK, Weiss JM, Kim HS, Peinado H, Lyden D (2016) Extracellular vesicles in cancer: cell-to-cell mediators of metastasis. (springer.com)
Abnormal expression and altered activity of MMPs result in excessive extracellular matrix degradation and increased tumor metastasis in various cancers. (phiab.com)
The encoded protein possesses an extracellular domain which is composed of two immunoglobulin-like motifs at the N-terminal, followed by two fibronectin type-III motifs. (cancerindex.org)
Extracellular ST6GAL1, present in cancer exosomes or the freely soluble recombinant sialyltransferase, compensates for insufficient intrinsic ST6GAL1 by boosting cancer cell proliferation and increasing invasiveness. (nature.com)
The MUC1 protein, also known as polymorphic epithelial mucin or epithelial membrane antigen, has a large extracellular region, a transmembrane sequence, and a cytosolic domain. (medscape.com)
This protein is frequently overexpressed and aberrantly glycosylated on its extracellular region in breast cancer. (medscape.com)
Physiologically, the MUC1 protein may be involved in cell adhesion by decreasing the degree of cell-to-extracellular matrix and cell-to-cell interactions. (medscape.com)

The mevalonate pathway (MVP) activates the cell-signaling protein Arf6 that promotes breast cancer progression, a recent study found. (pharmacytimes.com)

Epidemiologic evidence indicates that lower circulating vitamin D levels are associated with a higher risk of ovarian cancer and that vitamin D supplementation is associated with decreased cancer mortality. (mdpi.com)
The key factor of cancer associated morbidity and mortality is principally attributable to the development of metastases. (intechopen.com)
Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A and Bray F: Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. (spandidos-publications.com)
Cancer is the leading cause of death in Israel (approximately 25% of all-cause mortality) and is a major cause of morbidity in the population (3). (cdc.gov)
In Sweden, there has been a steady prostate-specific antigen (PSA) velocity for the diagnosis of pros- decrease in age-standardized breast cancer mortality in women up tate cancer (15). (lu.se)
A recent study of the disparity in breast cancer mortality between AA and EA women concluded that differences in mortality are driven by higher hazard rates of breast cancer death in AA women, irrespective of ER expression [ 9 ]. (cdc.gov)

A similar observation was made when this analysis was expanded for all multi-transmembrane domain (TMD)-containing human membrane proteins coded for by the human genome. (edu.au)

Because expression of Protein 4.1B is frequently down-regulated in human clinical prostate cancer as well as in a spectrum of other tumor types, these results suggest a more general role for Protein 4.1B as a negative regulator of cancer progression to metastatic disease. (umn.edu)
Accurate management of any human disease requires a thorough understanding of the molecular underpinnings (i.e., genome + epigenome + transcriptome + proteome + peptidome + protein post-translational modifications + metabolome + microbiome) driving the biology of that specific disease. (edu.au)
It specifically adds value to the task of 'knowing thyself' in strictly molecular terms by mapping the ~20,000 proteins encoded by the human genome. (edu.au)
microRNA-183-3p Inhibits Progression of Human Prostate Cancer by Downregulating High-Mobility Group Nucleosome Binding Domain 5. (cancerindex.org)
The sialyltransferase ST6GAL1 that adds α2-6 linked sialic acids to N-glycans of cell surface and secreted glycoproteins is prominently associated with many human cancers. (nature.com)
Blom A. M . , Berggård K., Webb J. H., Villoutreix B., Lindahl G. and Dahlbäck B. (2000) Human C4b-binding protein has overlapping but not identical binding sites for C4b and streptococcal M-proteins. (lu.se)
pendent of those associated with cretory ducts, columnar epithelia the KRAS gene is more frequent- other key mechanistic characteris- lining the gastrointestinal tract and ly mutated in human cancer, which tics of IARC Group 1 carcinogens. (who.int)

Since traditional cytotoxic chemotherapy has only little effect on MTCs, targeting hypoxia-associated and -regulated proteins might be of benefit for patients. (ox.ac.uk)
20% of CRC patients have metastasis at diagnosis. (hindawi.com)
[ 1 , 2 ] is a deadly form of musculoskeletal cancer that most commonly causes patients to die of pulmonary metastatic disease (see the image below). (medscape.com)
Proteins were validated with targeted proteomics using parallel reaction monitoring (PRM) in a validation set consisting of samples from the above patients. (frontiersin.org)
We previously reported that preoperative IVR treatment in patients with severe PDR contributes to a decreased risk of postoperative neovascular glaucoma ( 11 ), and found further changes in vitreous protein profiles of PDR patients treated with and without IVR ( 12 ). (frontiersin.org)
Retinoid differentiation therapy could be significantly effective against colon cancer, not only for treatment of existing disease but also as a preventive measure in high-risk patients. (sciencedaily.com)
Les concentrations sériques de sCD40L circulant et d'interleukine 10 circulante ont été analysées à l'aide de la méthode immuno-enzymatique chez 30 patients positifs pour le VHC avec un CHC, chez 30 patients patients positifs pour le VHC avec une cirrhose du foie, et chez 30 volontaires d'âge correspondant en bonne santé avec des anticorps anti-VHC négatifs servant de groupe témoin. (who.int)
However, a simple way to screened 240 sera from 64 patients with primary breast cancer. (lu.se)
This risk assessment was not dependent on the type of adju- decoding patterns of immunoregulatory serum proteins could re- vant therapy received by the patients. (lu.se)
The samples were collected from breast cancer patients rent procedures. (lu.se)
These drugs were found to be useful both preoperatively and postoperatively in patients with osteosarcoma, a discovery made at the Sloan-Kettering Memorial Cancer Center somewhat serendipitously while custom-made prostheses were being fabricated for patients awaiting surgery. (medscape.com)
Insufficient tissue oxygenation, or hypoxia, contributes to tumor aggressiveness and has a profound impact on clinical outcomes in cancer patients. (lu.se)
We also highlight how HIFs may be targeted to improve the management of patients with therapy-resistant and metastatic cancer. (lu.se)
During follow-up, 33 patients (20.8%) presented symptomatic metastasis. (who.int)
Furthermore, approximately 25 per cent of patients initially diagnosed with localised renal cancer will later experience metastases. (lu.se)

We believe this is the first time that phase separation has been implicated in cancer metastasis," said Yibin Kang , the Warner-Lambert/Parke-Davis Professor of Molecular Biology. (princeton.edu)
The projects feature state-of-the-art methods for the investigation of cell biology, such as flow cytometry and confocal microscopy, protein interaction analyses using the proximity-ligation assay and Biacore, and genetic manipulation employing the Cas9/CRISPR system. (lu.se)
Cancer biology & therapy 0 2 (6): 652-5. (cdc.gov)

What pathways are this gene/protein implicaed in? (cancerindex.org)

0.01), 210 differentially abundant cell surface proteins with at least one transmembrane domain were found. (muni.cz)

The results of non-smoker females with primary CA15-3) suspicion of symptomatic serum CEA assay can reflect progno- breast cancer, without signs or symp- metastasis. (who.int)

They function in a variety of developmental and physiological processes, including INFLAMMATION, lipid metabolism, hematopoietic stem cell activity, and cancer metastasis. (bvsalud.org)

Anatomy13

Organisms4

Diseases67

Chemicals and Drugs52

Analytical, Diagnostic and Therapeutic Techniques and Equipment77

Psychiatry and Psychology1

Phenomena and Processes39

Disciplines and Occupations2

Anthropology, Education, Sociology and Social Phenomena2

Humanities1

Information Science8

Named Groups1

Health Care26

Geographicals3

Genes18

Invasion17

Progression and metastasis3

Prognosis17

Tumors16

Proliferation and metastasis3

Mutations17

Overexpression7

Apoptosis3

Metastatic breast cancer8

Recurrence5

Mechanisms13

Inhibition7

Angiogenesis2

Recombinant Proteins2

Promote metastasis1

Colorectal10

Survival18

Epithelial-mesenchyma2

Mutation2

Promotes tumor1

Biomarkers4

Cells80

Immunohistochemistry1

Lung37

Bone metastasis1

Tumour3

Liver6

Roles5

Mice1

Associated with lymph node1

20213

Gene regulation1

Targets4

Microenvironment2

Single Nucleotide P1

Growth11

Fibroblasts1

Inhibit2

Therapeutic8

Pancreatic14

Kinase5

Lymph6

Inhibitor1

Hepatocellular1

Extracellular7

Breast cancer progression1

Mortality6

Membrane Proteins1

Human7

Patients15

Biology3

Pathways1

Cell surface proteins1

Assay1

Metabolism1