Germ-Line MutationLi-Fraumeni SyndromeMutation, MissenseMutationDNA Mutational AnalysisPedigreeGenes, p53Polymerase Chain ReactionHeterozygoteGenetic Predisposition to DiseasePoint MutationBase SequenceMolecular Sequence DataBreast NeoplasmsMicrosatellite RepeatsGenotypeCell LineGerm CellsFrameshift MutationCell Line, TumorNeoplasms, Germ Cell and EmbryonalRNA, MessengerEarly Detection of CancerAllelesAmino Acid SequenceSpermatogenesisExonsPhenotypeTestisOvarian NeoplasmsLung NeoplasmsMutation RateReverse Transcriptase Polymerase Chain ReactionDNA-Binding ProteinsGonadsGene Expression Regulation, NeoplasticDNA PrimersProstatic NeoplasmsTranscription FactorsAmino Acid SubstitutionNeoplasm ProteinsPromoter Regions, GeneticWheat Germ AgglutininsSequence Analysis, DNAPolymorphism, Single-Stranded ConformationalColonic NeoplasmsHomozygoteTranscription, GeneticTransfectionNeoplasmsDNA, NeoplasmCaenorhabditis elegansCell Line, TransformedStomach NeoplasmsNuclear ProteinsBlotting, WesternSpermatozoaDNAOogenesisGerm LayersMutagenesisMice, NudeChromosome MappingDNA MethylationSignal TransductionNeoplasm MetastasisDrosophila melanogasterGene ExpressionNeoplasm InvasivenessGene Expression ProfilingGenetic TestingMutagenesis, Site-DirectedSex Determination AnalysisPancreatic NeoplasmsCloning, MolecularAntineoplastic AgentsGene Expression Regulation, DevelopmentalSequence DeletionCaenorhabditis elegans ProteinsSpermatogoniaMice, TransgenicTumor Suppressor Protein p53ApoptosisGene DeletionTesticular NeoplasmsCell DifferentiationCell Transformation, NeoplasticPolymorphism, GeneticProtein BindingMembrane ProteinsDrug Resistance, NeoplasmProtein Structure, TertiaryGenes, BRCA1Colorectal NeoplasmsSequence Homology, Amino AcidGene Expression RegulationCell ProliferationProto-Oncogene ProteinsImmunohistochemistryCell Survival