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  • Molecular
  • A long-term goal is to use information gleaned from molecular and mechanistic studies to improve cancer treatment. (massgeneral.org)
  • Concentrating on molecular biomarkers in cancer research, Cancer Biomarkers publishes original research findings (and reviews solicited by the editor) on the subject of the identification of markers associated with the disease processes whether or not they are an integral part of the pathological lesion. (iospress.com)
  • Methods: 108 … formalin-fixed and paraffin-embedded breast cancer specimens (of invasive ductal carcinoma "NOS" type) from the pathology archive of Alzahra hospital(Isfahan, Iran) which had been studied for expression of routine molecular biomarkers were selected. (iospress.com)
  • Our work focuses on understanding the molecular differences between functional CD8 T cells and dysfunctional, exhausted CD8 T cells that are characteristic of chronic infection and cancer. (harvard.edu)
  • The discovery of molecular markers associated with various breast cancer subtypes has greatly improved the treatment and outcome of breast cancer patients. (biomedcentral.com)
  • As the survival rate of patients with colon cancer can be increased with effective treatment in its nonmetastatic phase, an extensive study of the underlying molecular networks of colon cancer metastasis is important for the discovery of novel prognostic molecular markers for colon cancer diagnosis and also for the development of effective targeted therapy for patients with metastatic colon cancer. (hindawi.com)
  • Ribociclib
  • NYSE: NVS) application for FDA approval of ribociclib for first-line use alongside letrozole, in patients who have advanced breast cancer with an amenable genetic makeup, has been accepted by regulators under priority review. (foxbusiness.com)
  • Unsurprisingly for cancer treatments, adverse events were significantly more common in the ribociclib arm than the placebo arm. (foxbusiness.com)
  • Melanoma
  • Melanoma is less common than nonmelanoma skin cancer, but 5% to 10% of all melanomas arise in multiple-case families and may be inherited in an autosomal dominant fashion. (oncolink.org)
  • Most of the psychosocial literature about hereditary skin cancers has focused on patients with familial melanoma. (oncolink.org)
  • In individuals at risk of familial melanoma, psychosocial factors influence decisions about genetic testing for inherited cancer risk and risk-management strategies. (oncolink.org)
  • CDK6 overexpression has also been implicated in lymphoma, melanoma and leukaemia. (news-medical.net)
  • apoptosis
  • Loss of these cell-cycle control and increased resistance to apoptosis (programmed cell death) represent major hallmarks of cancer . (omicsonline.org)
  • postmenopausal women
  • Depending on whether they are pre- or postmenopausal, women with advanced breast cancer may receive aromatase inhibitors, such as letrozole, anastrozole, and exemestane, or other estrogen-blocking drugs, such as toremifene, fulvestrant, and tamoxifen. (jons-online.com)
  • Because postmenopausal women with estrogen receptor-positive breast cancer can live with their disease for several years, treatments that maximize efficacy and minimize toxicity are crucial. (jons-online.com)
  • Therapeutic
  • This review was briefly described the above-mentioned possible roles of CDKs in the physiological and pathological mechanisms of cancer, further discussing recent advances and challenges in CDKs as a therapeutic target. (omicsonline.org)
  • We found a novel therapeutic window that attacks the dependency of a cancer cell on its growth regulator ", said Uras. (eurekalert.org)
  • Global Markets Directs, Human papillomavirus (HPV) Associated Cancer - Pipeline Review, H2 2015, provides an overview of the Human papillomavirus (HPV) Associated Cancers therapeutic pipeline. (marketresearchreports.biz)
  • This report provides comprehensive information on the therapeutic development for Human papillomavirus (HPV) Associated Cancer, complete with comparative analysis at various stages, therapeutics assessment by drug target, mechanism of action (MoA), route of administration (RoA) and molecule type, along with latest updates, and featured news and press releases. (marketresearchreports.biz)
  • It also reviews key players involved in the therapeutic development for Human papillomavirus (HPV) Associated Cancer and special features on late-stage and discontinued projects. (marketresearchreports.biz)
  • Uncovering the mechanisms by which autophagy and DDR are intertwined provides novel insight into the pathobiology of conditions associated with accumulation of DNA damage, including cancer and aging, and novel concepts for the development of improved therapeutic strategies against these pathologies. (frontiersin.org)
  • The potential of miRNAs used as biomarkers in the diagnosis, prognosis, and therapeutic targets in colon cancer is also discussed. (hindawi.com)
  • tissues
  • Materials and Methods: Tumor tissues (punch biopsies) were collected from 52 oral cancer patients and as a control, 8 independent adjacent normal tissue samples were also obtained. (koreascience.or.kr)
  • Cyclin D1
  • Gautschi O, Ratschiller D, Gugger M, Betticher DC, Heighway J. Cyclin D1 in non-small cell lung cancer: a key driver of malignant transformation. (springer.com)
  • patients
  • 2 Patients with these hormone receptor (HR)-positive cancers are most often treated with hormone therapy. (jons-online.com)
  • A potential drug for helping cancer patients withstand the side effects of chemotherapy showed positive results in a recent Phase 2 clinical trial involving small cell lung cancer, according to its developer, G1 Therapeutics of Research Triangle Park. (ncbiotech.org)
  • Small cell lung cancer is difficult to treat, particularly in later lines of therapy, and trilaciclib has shown potential to improve outcomes for these patients," said Raj Malik, M.D., G1's chief medical officer and senior vice president of R&D. "We now have four randomized Phase 2 trials showing trilaciclib's multi-lineage myelopreservation benefits. (ncbiotech.org)
  • It is intended as a resource to inform and assist clinicians who care for cancer patients. (oncolink.org)
  • Correction to: A phase I study of LY3164530, a bispecific antibody targeting MET and EGFR, in patients with advanced or metastatic cancer. (nih.gov)
  • A phase I study of LY3164530, a bispecific antibody targeting MET and EGFR, in patients with advanced or metastatic cancer. (nih.gov)
  • It has been revealed that approximately one-third of patients with colon cancer have synchronous or metachronous metastasis. (hindawi.com)
  • cell-cycle
  • The cell-cycle kinase CDK6 has attracted considerable attention over the past decade. (aacrjournals.org)
  • therefore, cancer is considered as a proliferative disorder and targeting the cell cycle, therefore, seems to be a good strategy for new targeted anticancer agents. (omicsonline.org)
  • A kinase-independent function of CDK6 links the cell cycle to tumor angiogenesis. (springer.com)
  • Malumbres M, Barbacid M. Cell cycle, CDKs and cancer: a changing paradigm. (springer.com)
  • Cell cycle arrest at sub-G1 phase was induced by rosamultic acid along with downregulation of expression levels of CDK4, CDK6 and cydin D1. (thefreedictionary.com)
  • Since CDKS drive the cell cycle forward, CDK inhibitors have been suggested as a possible treatment for cancer. (news-medical.net)
  • metastasis
  • About 1.2 million new cases are diagnosed and it causes 0.6 million deaths annually around the world, of which cancer metastasis is the main cause of death [ 1 ]. (hindawi.com)
  • treatment
  • G1 is a clinical-stage oncology company with three clinical-stage programs - trilaciclib , lerociclib and G1T48 - that are designed to enable more effective combination treatment strategies and improve patient outcomes across multiple cancers. (ncbiotech.org)
  • Treatment of hereditary skin cancers is similar to the treatment of sporadic skin cancers. (oncolink.org)