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  • carcinomas
  • 9FY can accurately discriminate between ERG positive prostate cancer cells and lymphocytes and other cell types, helping to establish prostatic origin in metastatic carcinomas to lymph nodes or other metastatic sites. (biocare.net)
  • gastric cancer
  • Adjuvant chemoradiotherapy after d2-lymphadenectomy for gastric cancer: the role of n-ratio in patient selection. (springer.com)
  • Adjuvant chemoradiotherapy is part of a multimodality treatment approach in order to improve survival outcomes after surgery for gastric cancer. (springer.com)
  • N-category and N-ratio interaction, perineural invasion and extended resections were prognostic factors for survival in gastric cancer patients treated with D2-lymphadenectomy, but adjuvant chemoradiotherapy was not. (springer.com)
  • The aims of this study are to describe the results of gastrectomy with or without adjuvant chemoradiotherapy in gastric cancer patients treated in a single institution, and to identify prognostic factors that could help establish subgroups of patients who would benefit from this treatment. (springer.com)
  • Though incidence and mortality of gastric cancer has declined in many countries over the past 50 years, there has been an increase in occurrences of gastric SRCC-type cancers. (wikipedia.org)
  • One study suggests that when signet-ring cells are found in a breast tumor, the presence of gastric cancer should also be considered. (wikipedia.org)
  • The role of other risk factors in gastric cancer such as salt-preserved food, smoking, auto-immune gastritis are not well studied in SRCC. (wikipedia.org)
  • This includes patients diagnosed with gastric adenocarcinoma (especially those with early-stage disease), patients found to have atrophic gastritis or intestinal metaplasia, as well as first-degree relatives of patients with gastric adenocarcinoma since the relatives themselves are at increased risk of gastric cancer partly due to the intrafamilial transmission of H. pylori. (wikipedia.org)
  • mucin
  • Highly differentiated adenocarcinomas form SRCCs via a loss of adherens and tight junctions that typically separate MUC4, a mucin protein, and ErbB2, an oncogenic receptor. (wikipedia.org)
  • Pseudomyxoma peritonei (PMP) is a clinical condition caused by cancerous cells (mucinous adenocarcinoma) that produce abundant mucin or gelatinous ascites. (wikipedia.org)
  • lung cancer
  • AURORA, Ontario, November 19, 2008 /PRNewswire/ -- Helix BioPharma Corp. today announced that it will present preclinical data about the mechanism of action for L-DOS47, the first drug candidate under development based on the Company's DOS47 technology, at The Second Conference of Lung Cancer on November 22, 2008, at the Hyatt Regency Hotel in Warsaw, Poland. (drugs.com)
  • By doing so at the site of cancerous tissues in the body, L-DOS47 is believed to modify the microenvironmental conditions of lung cancer cells in a manner that leads to their death. (drugs.com)
  • High miR-708 expression levels are observed in lung cancers due to their oncogenic role in lung cancer tumour growth and progression. (wikipedia.org)
  • pancreatic
  • ARBs for the Treatment of Pancreatic Cancer? (pancreatica.org)
  • The authors find and postulate that losartan appears to be the right ARB to optimally increase vascular perfusion and oxygen delivery in the stroma laden environment of pancreatic adenocarcinomas. (pancreatica.org)
  • As a part of the study losartan was given together with chemotherapy drugs including 5-FU and doxorubicin, and appears to potentiate chemotherapy delivery to the tumor site in pancreatic cancer. (pancreatica.org)
  • The authors end by postulating that drugs such as losartan (ARBs) might be considered for further evaluation as adjuvant to standard chemotherapy for pancreatic cancer. (pancreatica.org)
  • The mission of the foundation is to promote awareness, increase education, and further pancreatic cancer research. (pancreatica.org)
  • Join us in our effort to fight pancreatic cancer. (pancreatica.org)
  • Examples include: Pancreatic adenocarcinoma is often associated with mutations in the CDKN2A gene. (wikipedia.org)
  • mutation
  • On one end, the hypermethylation, mutation, or deletion of p16 leads to downregulation of the gene and can lead to cancer through the dysregulation of cell cycle progression. (wikipedia.org)
  • prevention
  • The Company is actively developing innovative products for the prevention and treatment of cancer based on its proprietary technologies. (drugs.com)
  • While 5α-reductase inhibitors appear to decrease low-grade cancer risk they do not affect high-grade cancer risk and thus are not recommended for prevention. (wikipedia.org)
  • Asian Pacific Journal of Cancer Prevention. (wikipedia.org)
  • rectal cancer
  • Gunderson LL, Jessup JM, Sargent DJ, Greene FL, Stewart A. Revised tumor and node categorization for rectal cancer based on surveillance, epidemiology, and end results and rectal pooled analysis outcomes. (springermedizin.de)
  • Secure scope in place with Martin Arm Courtesy Peter Cataldo, MD TEM Technique Direct view through stereoscope or on monitor Courtesy Peter Cataldo, MD Technique Inject lesion with lidocaine w/ epinephrine Courtesy Peter Cataldo, MD ENDOSCOPIC VIEW Multifocal Dysplastic Adenoma (TEM Specimen) T1 Polypoid Cancer TEM specimen T2 Adenocarcinoma of Mid Rectum TEM VIDEO TEM for Rectal Cancer? (slidegur.com)
  • 2006 "Mesorectal grades predict recurrences after curative resection for rectal cancer. (slidegur.com)
  • signet
  • For example, neoplasms characterized by high-grade features, invasive glands and or signet ring cells, are termed adenocarcinoma in pathology literature. (wikipedia.org)
  • alterations
  • Mutations resulting in deletion or reduction of function of the CDKN2A gene are associated with increased risk of a wide range of cancers and alterations of the gene are frequently seen in cancer cell lines. (wikipedia.org)
  • breast
  • my aunt was suffering from breast cancer. (unews.top)
  • Because of its additional activity against Her2, it is being investigated for breast cancer as well as other EGFR and Her2 driven cancers. (wikipedia.org)
  • verification needed] Phase II results for breast cancer that over-expresses the protein human epidermal growth factor receptor 2 (Her2-positive breast cancer) were described as promising by the authors, with 19 of 41 patients achieving benefit from afatinib. (wikipedia.org)
  • Her2-negative breast cancers showed limited or no response to the drug. (wikipedia.org)
  • Breast Cancer Research and Treatment. (wikipedia.org)
  • cells
  • Dr. Chao will highlight previously announced laboratory and animal data that demonstrates the potential for L-DOS47 to bind to and debilitate and destroy human lung adenocarcinoma cells. (drugs.com)
  • Among these theorized effects, L-DOS47 is believed to stimulate an increase in the pH of the microenvironment surrounding the cancerous cells, effectively reversing the acidic extra-cellular conditions that are known to be necessary for cancer cell survival. (drugs.com)
  • In addition, the local production of ammonia at the site of cancerous tissues is thought to readily diffuse into the cancer cells to exert a potent cytotoxic effect by interfering with their critical metabolic functions. (drugs.com)
  • It works by preventing cancer cells from multiplying and it also makes them more likely to die from the treatment. (clinicaltrials.gov)
  • Pasireotide works by binding to a protein called somatostatin receptor, which is expressed in many tissues throughout the body including thyroid cancer cells. (clinicaltrials.gov)
  • MAJOR CANCER BREAKTHROUGH: Scientists Find Plant That Kills 98% Of Cancer Cells In Just 16 Hours! (unews.top)
  • This reduction in the division and production of stem cells protects against cancer while increasing the risks associated with cellular senescence. (wikipedia.org)
  • The cancer cells may spread from the prostate to other area of the body, particularly the bones and lymph nodes. (wikipedia.org)
  • Thyroid Cancer
  • The purpose of this study is to determine the effectiveness of two anticancer drugs, everolimus and pasireotide, in patients with thyroid cancer when the cancer is no longer responding to treatment with radioiodine or where it is deemed unsafe for the patient to receive additional radioiodine treatment. (clinicaltrials.gov)
  • The investigators also want to establish the best manner of taking the two medications when used together to treat thyroid cancer. (clinicaltrials.gov)
  • Would this be good for thyroid cancer? (unews.top)
  • Genes
  • MLPA has a variety of applications including detection of mutations and single nucleotide polymorphisms, analysis of DNA methylation, relative mRNA quantification, chromosomal characterisation of cell lines and tissue samples, detection of gene copy number, detection of duplications and deletions in human cancer predisposition genes such as BRCA1, BRCA2, hMLH1 and hMSH2 and aneuploidy determination. (wikipedia.org)
  • Hypermethylation of tumor suppressor genes has been implicated in various cancers. (wikipedia.org)
  • Gene
  • ERG gene fusions are among the most validated cancer genome defects present in half of all prostate cancers in western countries. (biocare.net)
  • The gene is expressed at low levels in almost all human tissues, but higher levels have been seen in certain cancer tissues. (wikipedia.org)
  • curative
  • This retrospective study included patients with pathologically confirmed gastric adenocarcinoma who underwent surgical treatment with curative intent in a single cancer center in Brazil, between 1998 and 2008. (springer.com)
  • This is a retrospective study, which included patients with pathologically confirmed gastric adenocarcinoma who underwent surgical treatment with curative intent in a single cancer center in Brazil, in the period between September 1998 and December 2008. (springer.com)
  • bone
  • Spread of cancer into other bones such as the femur is usually to the proximal or nearby part of the bone. (wikipedia.org)
  • therapy
  • Helix BioPharma Corp. is a biopharmaceutical company specializing in the field of cancer therapy. (drugs.com)
  • biopsy
  • Foreman notices the shape of the fluid collection is odd, House recommends they do a dural biopsy to confirm brain cancer. (wikipedia.org)
  • form
  • L-DOS47 combines Helix's proprietary DOS47 new drug candidate with a highly specific, single-domain antibody to form a potential new targeted drug product for the treatment of lung adenocarcinoma, the most common form of cancer today. (drugs.com)
  • high
  • We conclude that individual CRNDE transcripts show promise as tissue and plasma biomarkers, potentially exhibiting high sensitivity and specificity for colorectal adenomas and cancers. (garvan.org.au)
  • HPV vaccines protect against between two and seven high-risk strains of this family of viruses and may prevent up to 90% of cervical cancers. (wikipedia.org)
  • research
  • for instance at Crocker Institute for Cancer Research. (wikipedia.org)
  • Laboratory rats are frequently subject to dissection or microdialysis to study internal effects on organs and the brain, such as for cancer or pharmacological research. (wikipedia.org)
  • PDAC
  • All patients diagnosed with a first primary PDAC in Sweden between 2006 and 2009 were identified through the Swedish Cancer Register (n=2,394). (aacrjournals.org)
  • epithelial
  • Coloured mammogram (breast X-ray) of an 82-year-old woman's right breast with an adenocarcinoma, a cancerous tumour (white, right) formed from glandular structures in epithelial tissue. (sciencephoto.com)
  • Adenocarcinomas can arise in many tissues of the body owing to the ubiquitous nature of glands within the body, and, more fundamentally, to the potency of epithelial cells. (wikipedia.org)
  • The β-elemene - a traditional Chinese medicine, upregulates MTA3's expression in breast cancer cells The MTA3-NuRD complex represses Snail, a master regulator of epithelial-to-mesenchymal transition (EMT), Wnt4 expression in mammary epithelial cells, and BCL6-corepressor target genes The MTA3-NuRD complex interacts with GATA3 to regulate the expression of GATA3 downstream targets. (wikipedia.org)
  • stomach cancer
  • Stomach cancer, also known as gastric cancer, is cancer developing from the lining of the stomach. (wikipedia.org)
  • Most of the time, stomach cancer develops in stages over years. (wikipedia.org)
  • Japan and South Korea, two countries that have high rates of the disease, screen for stomach cancer. (wikipedia.org)
  • Globally, stomach cancer is the fifth leading cause of cancer and the third leading cause of death from cancer making up 7% of cases and 9% of deaths. (wikipedia.org)
  • Stomach cancer occurs most commonly in East Asia and Eastern Europe. (wikipedia.org)
  • Stomach cancer is often either asymptomatic (producing no noticeable symptoms) or it may cause only nonspecific symptoms (symptoms that may also be present in other related or unrelated disorders) in its early stages. (wikipedia.org)
  • Stomach cancer can cause the following signs and symptoms: Early cancers may be associated with indigestion or a burning sensation (heartburn). (wikipedia.org)
  • Helicobacter pylori infection is an essential risk factor in 65-80% of gastric cancers, but only 2% of people with Helicobacter infections develop stomach cancer. (wikipedia.org)
  • The mechanism by which H. pylori induces stomach cancer potentially involves chronic inflammation, or the action of H. pylori virulence factors such as CagA. (wikipedia.org)
  • chemotherapy
  • Harnessing macrophage-derived exosomes as conveyers of antagomiRs augments the effect of chemotherapy against cancer, opening new therapeutic options against malignancies where resistance to nucleotide analogs remains an obstacle to overcome. (aacrjournals.org)
  • poorly
  • The role of the pathway in non-small lung cancer is poorly understood. (aacrjournals.org)
  • While some nasopharyngeal cancers are biologically similar to the common HNSCC, "poorly differentiated" nasopharyngeal carcinoma is lymphoepithelioma, which is distinct in its epidemiology, biology, clinical behavior, and treatment, and is treated as a separate disease by many experts. (wikipedia.org)
  • Surgeries
  • Surgeries for oral cancers include Maxillectomy (can be done with or without orbital exenteration) Mandibulectomy (removal of the mandible or lower jaw or part of it) Glossectomy (tongue removal, can be total, hemi or partial) Radical neck dissection Mohs procedure Combinational e.g., glossectomy and laryngectomy done together. (wikipedia.org)
  • Adenocarcinoma Cervical cancer staging Oncology List of surgeries by type Trachelectomy. (wikipedia.org)
  • tissues
  • The cancer can invade surrounding tissues and spread to other parts of the body (metastasis). (sciencephoto.com)
  • Adjacent non-cancer tissues and carcinoma tissues were selected from every patient. (aacrjournals.org)
  • Promoter methylation of RASSF1A could be detected in GCA (27/42, 64%), while only one was found in adjacent non-cancer tissues. (aacrjournals.org)
  • globally
  • In 2015 head and neck cancers globally affected more than 5.5 million people (mouth 2.4 million, throat 1.7 million, larynx 1.4 million) and resulted in more than 379,000 deaths (mouth 146,000, throat 127,400, larynx 105,900). (wikipedia.org)
  • invasive
  • When these glands undergo a number of changes at the genetic level, they proceed in a predictable manner as they move from benign to an invasive, malignant colon cancer. (wikipedia.org)
  • The gastroenterologist uses a colonoscopy to find and remove these adenomas and polyps to prevent them from continuing to acquire genetic changes that will lead to an invasive adenocarcinoma. (wikipedia.org)
  • cancerous
  • They explained that the mechanism behind smoking and anal-cancer development is unknown, but researchers speculate that smoking interferes with a process called apoptosis, or programmed cell death, which helps rid the body of abnormal cells that could turn cancerous. (wikipedia.org)
  • On 22 December 2010, the U.S. Food and Drug Administration approved Gardasil vaccine to prevent anal cancer and pre-cancerous lesions in males and females aged 9 to 26 years. (wikipedia.org)
  • survival
  • As there is significant long-term survival in the setting of node-positive disease, regional lymphadenectomy in patients with this type of adenocarcinoma may, in fact, be therapeutic in some patients. (cancernetwork.com)
  • Effective treatment strategies are currently lacking, and the 5-year survival is less than 5%, the lowest among all cancer patients ( 1 ). (aacrjournals.org)
  • Nevertheless, if the cancer is caught soon enough, patients can have a five-year survival rate of 90% or above. (wikipedia.org)
  • By the time esophageal cancer is usually detected, though, it might have spread beyond the esophageal wall, and the survival rate drops significantly. (wikipedia.org)
  • HPV-positive oropharyngeal cancer generally has a better outcomes than HPV-negative disease with a 54% better survival, but this advantage for HPV associated cancer applies only to oropharyngeal cancers. (wikipedia.org)
  • arises
  • Nasopharyngeal cancer arises in the nasopharynx, the region in which the nasal cavities and the Eustachian tubes connect with the upper part of the throat. (wikipedia.org)