Cancer wnt signaling pathway. Medical search. Frequent questions

The DEA and the Heinz analyses suggest 20 Wnt and Ras-MAPK signalling genes being deregulated by AURKA, whereof β-catenin and KRAS occurred in both cell lines. (vu.nl)
Finally, shortest path analysis over the PPI network revealed eight 'connecting genes' between AURKA and these Wnt and Ras-MAPK signalling genes, of which UBE2D1, DICER1, CDK6 and RACGAP1 occurred in both cell lines. (vu.nl)
This study, first, confirms that AURKA influences deregulation of Wnt and Ras-MAPK signalling genes, and second, suggests mechanisms in CRC cell lines describing these interactions. (vu.nl)
Genetic association studies have successfully revealed several important genes consistently associated with gastric cancer to date. (oncotarget.com)
However, these robust gastric cancer-associated genes do not fully elucidate the mechanisms underlying the development and progression of the disease. (oncotarget.com)
Also, Quantitative RT-PCR was used to evaluate the mRNA expression level of genes related to the Wnt signal pathway in treated cancer cells and control groups. (researchsquare.com)
Our data rule out a model suggesting that xKaiso is a direct repressor of Wnt signalling target genes in early Xenopus development via binding to promoter-proximal CTGCNA sequences as part of a xTcf3 repressor complex. (biologists.com)
In colorectal cancer, an early mutation leading to such features usually occurs in the APC or CTNNB1 genes, thereby activating Wnt signalling. (biomedcentral.com)
In reaction to Wnt activation we observe downregulation of location specific genes and differentiation markers. (biomedcentral.com)
A similar effect is seen in patient data, where genes with significant differential expression between the normal left and right colon are downregulated in the cancer samples. (biomedcentral.com)
Furthermore, the signature of Wnt target genes differs between the three intestinal locations in the organoids. (biomedcentral.com)
The location specific Wnt signatures are dominated by genes which have been lowly expressed in the tissue of origin, and are the targets of transcription factors that are activated following enhanced Wnt signalling. (biomedcentral.com)
The real-time PCR method was used to analyse the L. rhamnosus supernatant effect on the expression of Wnt signaling pathway genes. (hindawi.com)
The supernatant of this bacterium significantly reduced the expression of Wnt signaling pathway genes. (hindawi.com)
This study is the first report that assessed the potential impact of L. rhamnosus , especially its supernatant on esophageal cancer and Wnt signaling pathway genes. (hindawi.com)
In the presence of Wnt signals, the Wnt proteins bind to (frizzled) frizzled receptors ( FZDs ) and low-density lipoprotein receptor-related protein ( LRP ) receptors, leading to the stabilization of β-catenin , its transfer to the nucleus, and the activation of target genes. (hindawi.com)
β-catenin forms a complex with T-cell factor ( TCF ) /lymphoid enhancer factor ( LEF ) transcription factors and cofactors such as histone acetyltransferase p300 (p300), CBP, BCL9, and pygopus, to transcribe Wnt signaling target genes such as Cyclin D1 , C-Myc , and survivin [ 9 , 12 - 15 ]. (hindawi.com)
Independent experiments confirmed several target genes, including PLOD2 , HADH , LCOR and REEP1 as non-canonical target genes in various colon cancer cells. (nature.com)
Moreover, non-canonical Wnt target genes are regulated via RoR2, Dvl2, ATF2 and ATF4. (nature.com)
Although mutations in these same genes have not been observed as recurrent genetic events in breast tumors, there is strong evidence implicating Wnt/β-catenin activity in breast tumorigenesis. (plos.org)
This pathway describes progression of a serrated precursor lesion, often followed by the onset of epigenetic instability involving promoter methylation and silencing of key tumour suppressor genes, and accounts for 15%-20% of sporadic colorectal cancer [ 1 , 2 ]. (hindawi.com)
Somatic mutations in only three genes (TP53, PIK3CA and GATA3) occurred at >10% incidence across all breast cancers. (genome.jp)
In one study, 5 of 37 (13.5%) patients with medulloblastoma were found to have germline mutations in one of the known cancer predisposing genes. (medscape.com)
Association study of Wnt signaling pathway genes in bipolar disorder. (cdc.gov)

WNT, fibroblast growth factor (FGF), Notch, Hedgehog, and transforming growth factor β/bone morphogenetic protein signaling network are implicated in the maintenance of tissue homeostasis by regulating self-renewal of normal stem cells as well as proliferation or differentiation of progenitor (transit-amplifying) cells. (aacrjournals.org)
The Notch signaling pathway, also involved in embryogenesis, plays a key role in regulating cell differentiation, proliferation and programmed cell death (apoptosis), as well as the functioning of normal stem cells. (beforeitsnews.com)
Aberrant Notch signaling has been implicated in a wide range of cancers. (beforeitsnews.com)
Curcumin has been found to suppress tumor cells along the Notch pathway. (beforeitsnews.com)
Furthermore, the Wnt/β-catenin can crosstalk with other signaling pathways including Notch, FGF, Hedgehog, and TGF-β/BMP signaling cascades to form a signaling network to regulate the survival and progression of cancer cells ( 14 - 16 ). (frontiersin.org)
In patients suffering from TNBC, the deregulation of various signalling pathways (Notch and Wnt/beta-catenin), EGFR protein have been confirmed. (genome.jp)
New Rochelle, NY, April 4, 2016--A new study shows that Frizzled7 (FZD7), a protein present on human breast epithelial cells and a component of the Wnt signaling pathway is uniquely controlled by the Notch signaling pathway, both of which play key roles in mammary gland formation and breast cancer development. (eurekalert.org)
Evidence supporting the potential ability to regulate Notch-mediated Wnt signaling by targeting the NOTCH3-FZD7signaling network is presented in the study published in Stem Cells and Development , a peer-reviewed journal from Mary Ann Liebert, Inc., publishers . (eurekalert.org)
Vasudeva Bhat, Yu Jia Sun, Steve Weger, and Afshin Raouf, University Manitoba and CancerCare Manitoba, Winnipeg, Canada, determined how the Notch signaling pathway uniquely regulates a specific component of the Wnt signaling pathway--the FZD7receptor--in human breast epithelial cells. (eurekalert.org)
In the article "Notch-induced Expression of FZD7 Required Noncanonical NOTCH3 Signaling in Human Breast E0pithelial Cells" , the researchers provide evidence that Notch-induced expression of FZD7 is controlled only by the NOTCH3 receptor and in a unique way that differs from other demonstrated mechanisms of Notch-mediated modulation of the Wnt signaling pathway. (eurekalert.org)

Hyperactivation of Wnt and Ras-MAPK signalling are common events in development of colorectal adenomas. (vu.nl)
Here we first performed differential expression analysis (DEA) of AURKA knockdown in two colorectal cancer (CRC) cell lines with 20q gain and AURKA overexpression. (vu.nl)
Here, a novel mass spectrometry-based proteomics technique in colorectal cancer cells expressing stabilized β-catenin, was used to identify a protein-protein interaction between β-catenin and DNA methyltransferase I (Dnmt1) protein, the primary regulator of DNA methylation patterns in mammalian cells. (nih.gov)
Dnmt1 and β-catenin strongly colocalized in the nuclei of colorectal cancer cells, and the interaction is mediated by the central domain of the Dnmt1 protein. (nih.gov)
Two critical oncoproteins, Dnmt1 and β-catenin, mutually regulate one each other's levels and activities in colorectal cancer cells. (nih.gov)
Colorectal cancer is the second leading cause of cancer-related death in the United States. (novapublishers.com)
Among many gene mutations associated with colorectal cancer, mutation of APC (adenomatous polyposis coli) or ß-catenin, which activates Wnt signaling, represents the initiation step of colon tumorigenesis. (novapublishers.com)
We use a 3D in vitro organoid model to study the early phase of colorectal cancer development. (biomedcentral.com)
Colorectal cancer with liver metastases: Neoadjuvant chemotherapy, surgical resection first or palliation alone? (wjgnet.com)
Khan K, Wale A, Brown G, Chau I. Colorectal cancer with liver metastases: Neoadjuvant chemotherapy, surgical resection first or palliation alone? (wjgnet.com)
Colorectal cancer (CRC) is one of the commonest cancers with 1.2 million new cases diagnosed each year in the world. (wjgnet.com)
Colorectal cancer is one of the commonest cancers in the world. (wjgnet.com)
primarily based on better understanding of the molecular complexity of colorectal cancer coupled with aggressive approach in management of colorectal liver metastases. (wjgnet.com)
The BRAF oncogene is an integral component of the MAP kinase pathway, and an activating V600E mutation occurs in 15% of sporadic colorectal cancer. (hindawi.com)
Recent studies have found that they have clinical and molecular features of both the BRAF mutant/MSI and the conventional BRAF wild-type cancers and comprise a distinct colorectal cancer subgroup. (hindawi.com)
This review highlights the importance of the BRAF mutation occurring in colorectal cancer stratified for molecular background and discusses its prognostic and clinical significance. (hindawi.com)
In colorectal cancer, the presence of a BRAF mutation can be associated with an aggressive phenotype and is a key prognostic biomarker for poor outcome particularly in late-stage disease. (hindawi.com)
The BRAF V600E mutation occurs early in tumourigenesis and is highly correlated with the serrated neoplasia pathway of colorectal cancer. (hindawi.com)
BRAF mutant/MSS cancers form a distinct colorectal cancer entity that shares clinical and molecular features with both BRAF mutant/MSI serrated pathway cancers and the BRAF wild-type cancers of the conventional pathway [ 9 - 11 ]. (hindawi.com)
This latter pathway involves the previously well-defined series of genetic aberrations such as APC mutation and chromosomal instability and accounts for the majority of colorectal cancer [ 12 ]. (hindawi.com)
Although the relevance of mutant BRAF in the clinical setting is increasingly being acknowledged, the relatively low frequency of its occurrence requires further studies and larger experimental cohorts to secure its mutational status as a definitive biomarker for colorectal cancer. (hindawi.com)
Plus, research in 2019 suggested that K3 could suppress some activities of colorectal cancer cells. (greatist.com)

Canonical WNT signals are transduced through Frizzled family receptors and LRP5/LRP6 coreceptor to the β-catenin signaling cascade. (aacrjournals.org)
Epigenetic silencing and loss-of-function mutation of negative regulators of the canonical WNT pathway occur in a variety of human cancer. (aacrjournals.org)
Nonsteroidal anti-inflammatory drugs and PPARγ agonists with the potential to inhibit the canonical WNT signaling pathway are candidate agents for chemoprevention. (aacrjournals.org)
ZTM000990 and PKF118-310 are lead compounds targeted to the canonical WNT signaling cascade. (aacrjournals.org)
Moreover, AHNAK suppressed the progress of ovarian cancer partly via dampening the Canonical Wnt cascade. (aging-us.com)
The central effector of canonical Wnt signaling, β-catenin (CTNNB1), is a multifunctional protein, and has been extensively studied with respect to its roles in cell-cell adhesion and in regulation of Wnt-driven transcription. (nih.gov)
Canonical Wnt/β-catenin signaling is initiated by binding of Wnt ligands to Frizzled (Fzd)-LRP5/6 receptor complexes, leading to inactivation of the destruction complex and stabilization of β-catenin. (plos.org)
Activation of the non-canonical Wnt signaling pathway via Wnt5a has been correlated with increased migration and invasion as well as a poor prognosis in malignant melanoma patients. (lu.se)

The protein inhibits GSK-3-mediated phosphorylation of beta-catenin and positively regulates the Wnt signaling pathway. (nih.gov)
In addition, Wnt signaling also regulates the self-renewal and differentiation of adult stem cells. (novapublishers.com)
The Wnt signaling pathway regulates a wide range of processes during embryonic development, but are also dsyregulated in cancer. (beforeitsnews.com)
Another pathway involved in embryogenesis, the Hedgehog pathway also regulates normal stem cell activity. (beforeitsnews.com)
Wnt/β-catenin pathway regulates MGMT gene expression in cancer and inhibition of Wnt signalling prevents chemoresistance. (lu.se)

Then, we overexpressed AHNAK in vitro and in vivo to establish the roles of AHNAK in ovarian cancer cell proliferation and metastasis. (aging-us.com)
The effects of TMZ and KC7F2 on cancer cell viability and proliferation were investigated by WST-1 method. (researchsquare.com)
Wnt signal is known to play a significant role in many cellular processes such as cell proliferation, survival, self-renewal, and differentiation. (harvard.edu)
Lung cancer is a type of maligned cancer caused by the deterioration of cellular homeostasis due to various reasons, such as the unbalanced proliferation of cells in the lung, gene expression change, epigenetic factors, and mutation accumulation. (harvard.edu)
Cancer results from the accumulation of mutations leading to the acquisition of cancer promoting characteristics such as increased proliferation and resistance to cell death. (biomedcentral.com)
Cancer-preventing strategies of these beneficial bacteria such as binding to carcinogens and degrading them, stimulating anti-cancer enzymes, and preventing the conversion of procarcinogens to carcinogens, production of beneficial compounds that act as signaling molecules affecting the immune system, cell death, and proliferation, and interference with cell signaling pathways are reported [ 16 - 19 ]. (hindawi.com)
Furthermore, we show that the ligands Wnt5a/b are upstream regulators of the non-canonical signature and moreover regulate proliferation of cancer cells in a β-catenin-independent manner. (nature.com)
Our experiments indicate that colon cancer cells are dependent on both β-catenin-dependent and -independent Wnt signaling routes for growth and proliferation. (nature.com)
Major factors that may contribute to the proliferation of the leiomyoma are the decrease in the protein CCN5 and the expression of the gene HBP1--both of which are components of the Wnt signaling pathway, a fundamental pathway in normal development and in disease. (tufts.edu)
CCN5 is a matricelluar protein, which has a role in cell proliferation, angiogenesis, and progression of certain cancers. (tufts.edu)
This suggests the possibility that strictly regulated self-renewal mediated by Wnt signaling in cancer cells may be disturbed by the SUMOylation pathway to allow more malignant proliferation. (frontiersin.org)
Moreover, overexpression of microRNA-340-5p could suppress the invasion and proliferation of lung cancer cells. (ijpsonline.com)
Our results demonstrate that up-regulation of microRNA-340-5p attenuates lung cancer cell invasion and proliferation via inhibiting wingless-related integration site/beta-catenin pathway. (ijpsonline.com)
They found that they were able to inhibit both Wnt signaling and cell proliferation in another cell line, without affecting a non-cancerous breast cell line. (unige.ch)
Here we identify CSNK1E , the gene encoding casein kinase 1 epsilon (CK1ε) as required specifically for the proliferation of breast cancer cells with activated β-catenin and confirm its role as a positive regulator of β-catenin-driven transcription. (plos.org)
The Wnt/β-catenin pathway plays a critical role in embryonic development, maintenance of multipotent progenitor cell populations and proliferation of many tissue types [1] , [2] . (plos.org)
In addition to the pathogonomic translocation , MCL progression is controlled by secondary genetic abberations and dysregulated signaling pathways involved in DNA damage repair , proliferation , and apoptosis . (wikidoc.org)
The Wnt signaling pathway promotes the growth and division (proliferation) of cells and helps determine the specialized functions a cell will have (differentiation). (medlineplus.gov)
This active beta-catenin protein promotes Wnt signaling longer than normal, which leads to the unchecked proliferation of kidney cells and tumor development. (medlineplus.gov)
BRAF is a protein kinase and part of the MAP kinase signalling cascade which involves transduction of a growth signal from the cell membrane to the nucleus via a chain of protein kinases and is responsible for cellular proliferation and survival. (hindawi.com)

APC, WNT signaling pathway regulator is a protein that in humans is encoded by the APC gene. (wikipedia.org)
This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. (wikipedia.org)
In summary, a functional protein-protein interaction was identified between two critically important oncoproteins, in turn revealing a link between Wnt signaling and downstream nuclear functions mediated by Dnmt1. (nih.gov)
Frequently, mesenchymal and hematopoietic progenitors are associated with the action of parathyroid hormone-related protein (PTHrP), a well-known regulator of tumour-associated bone destruction [ 1 ], as well as with the hypercalcemia seen in many types of cancer [ 2 ]. (aging-us.com)
In wild type cells, Wnt family protein members (e.g. (biomedcentral.com)
In the absence of Wnt signals, the cytoplasmic catenin beta-1 ( β-catenin ) is associated with a complex including auxin, glycogen synthase kinase 3 ( GSK-3 ), and adenomatous polyposis coli ( APC ) (the APC protein acts as the primary regulator of β-catenin function). (hindawi.com)
What pathways are this gene/protein implicaed in? (cancerindex.org)
CCN5 is equivalent to WISP2 (Wnt-Inducible Secreted Protein 2). (tufts.edu)
Signaling is initiated when the Wnt ligand binds to the Frizzled receptor on the cell membrane and the LDL receptor-associated protein 5/6 (LRP5/6) co-receptor. (frontiersin.org)
The Rap2 interacting protein 9 (RPIP9) is highly expressed in human breast carcinomas and correlates with a poor prognosis, suggesting a role for Rap2 in breast cancer oncogenesis. (nih.gov)
The deduced 4660-aa sequence, expected to constitute a mature protein of M(r) 516,715, consists of a probable N-terminal signal peptide sequence (25 aa), an extracellular region (4400 aa), a single transmembrane domain (22 aa), and a C-terminal cytoplasmic tail (213 aa). (embl.de)
and 3) define the causality between TNF-α, one of the mot critical inflammatory cytokines, and Wnt signaling by measuring the gene expression of the Wnt targets in samples from normal to overweight and obese postmenopausal women treated with anti-TNF-α antibody or TNF-α recombinant protein respectively. (umass.edu)
The beta-catenin protein is also involved in cell signaling as an essential part of the Wnt signaling pathway. (medlineplus.gov)
Certain proteins in this pathway attach (bind) to beta-catenin, which triggers a multistep process that allows the protein to move into the cell nucleus. (medlineplus.gov)
The purpose of this study was to investigate the role of m 6 A demethylase fat mass and obesity-associated protein (FTO) in the tumor metastasis of non-small cell lung cancer (NSCLC). (bvsalud.org)

In embryonic Xenopus development, Rap2 is necessary for the Wnt/beta-catenin signaling pathway. (nih.gov)

Wnt signaling pathways control a wide range of processes during embryonic development and tissue homeostasis. (nature.com)
It contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. (novusbio.com)
The Wnt signaling pathway is highly conserved and crucial during embryonic development. (lu.se)

The human WNT gene family consists of 19 members, encoding evolutionarily conserved glycoproteins with 22 or 24 Cys residues ( 1 ). (aacrjournals.org)
Wnt signaling is an evolutionarily conserved signaling route required for development and homeostasis. (nature.com)

This pathway has been linked to various types of cancer after the definition of mutations and various dysfunctions after the discovery of this pathway. (harvard.edu)
However, substantial phenotypic differences between cancers originating within the same organ, such as molecular subtypes, are not fully reflected by differences in mutations. (biomedcentral.com)
It is believed that mutations in the deoxyribonucleic acid (DNA) signal the cells related to the esophagus to multiply abnormally [ 4 , 5 ]. (hindawi.com)
Loss-of-function mutations in APC or AXIN or activating mutations in the gene encoding β-catenin, CTNNB1 , lead to aberrant activation of Wnt/β-catenin signaling and have been causally linked to tumorigenesis of the colon, liver and skin [1] , [4] . (plos.org)
Mutations in the CTNNB1 gene have been found in Wilms tumor, a rare form of kidney cancer that occurs almost exclusively in children. (medlineplus.gov)
The first piece of information, which was a little surprising, was that there was no significant impact of any of the mutations on outcome, including the BRAF amplifications, mutations in the MAP kinase pathway, or MEK1/2 mutations. (medscape.com)
No. But what we do see is that in patients with low TMB and low interferon gamma, there were mutations in the Wnt signaling pathway and beta-catenin, which we know bodes a poor outcome. (medscape.com)

Expression of DKK1 inhibited the Wnt/β-catenin signaling pathway and partially rescued osteogenic differentiation of MSCs. (aging-us.com)
In HER2 positive breast tumours, HER2 activates the PI3K/AKT and the RAS/RAF/MAPK pathways, and stimulate cell growth, survival and differentiation. (genome.jp)

Curcumin has been found to inhibit the Hedgehog pathway through a number of different mechanisms. (beforeitsnews.com)
The scientists then checked whether their compounds could inhibit the Wnt signaling pathway in other triple-negative breast cancer cell lines. (unige.ch)
In addition to ligand-regulated degradation of β-catenin, Wnt signaling is antagonized by extracellular factors that inhibit the ability of Wnt ligands to bind to Fzd and initiate signaling, such as the secreted frizzled-related proteins (SFRP1, WNT inhibitory factor (WIF) and dickkopf (DKK) [3] . (plos.org)
Functional studies show that SFRP3 can inhibit Wnt5a signaling and induce a decrease in migration and invasion. (lu.se)

In mammals, the family of Wnt ligands consists of 19 members, which trigger multiple intracellular signaling cascades and orchestrate complex, context-dependent responses. (nature.com)

However, predicting the signaling outcome of different Wnt ligands has remained difficult. (nature.com)
In the absence of Wnt ligands, a complex containing APC, AXIN and GSK3 phosphorylates β-catenin, marking it as a substrate for ubiquitination by β-TrCP and subsequent proteasomal degradation. (plos.org)
This signal transduction pathway is initiated by epidermal growth factor ligands binding to and activating receptor tyrosine kinases (RTK) at the cell membrane. (hindawi.com)

In addition, Wnt/β-catenin has emerged as a critical regulator of cancer stem cells (CSCs), which is considered one of the root causes of cancer recurrence and metastasis because of their heterogeneity and plasticity ( 13 ). (frontiersin.org)
Axin is a tumor suppressor and a key negative regulator of the Wnt/β-catenin signaling pathway. (rcsb.org)

There is a need to elucidate on the mechanisms involved in ovarian cancer progression and to identify novel cancer targets. (aging-us.com)
Both mechanisms are found to increase Wnt signalling in early carcinogenesis in the intestine. (biomedcentral.com)
Further analyses seek to define the Wnt signaling mechanisms and are focused on our lab's unique organotypic model of leiomyoma, in which human fibroid tumors are grown in immune-compromised mice. (tufts.edu)
This has led to an improved understanding of the multilayered mechanisms of this pathway transduction proceeds as well as the molecular mechanism regulating this pathway ( 28 ). (frontiersin.org)
However, the mechanisms involved in the relationship between obesity and breast cancer are still not fully understood. (umass.edu)
This thesis highlights the complexity of Wnt signaling in general and Wnt5a signaling in melanoma in particular and extends our knowledge of the mechanisms behind progression of malignant melanoma. (lu.se)

WNT signals are context-dependently transduced to both pathways based on the expression profile of WNT, SFRP, WIF, DKK, Frizzled receptors, coreceptors, and the activity of intracellular WNT signaling regulators. (aacrjournals.org)
Hence, LMWH reduces the cisplatin-induced rise in Wnt activity and TCF-4 expression in A2780cis cells, but keeps sensitive A2780 cells unaffected. (oncotarget.com)
Therefore, we investigated the combined effect of Temozolomide (TMZ) and KC7F2 on cell survival and changes in gene expression in the Wnt signal pathway. (researchsquare.com)
The gene expression before and after Wnt activation is compared within each intestinal origin and across the three locations using RNA sequencing. (biomedcentral.com)
It's over expression has been linked to the progression from inflammation to cancer. (beforeitsnews.com)
Gene expression profiling was performed after silencing of key components of Wnt signaling pathway and an iterative signature algorithm was applied to predict pathway-dependent gene signatures. (nature.com)
β-catenin then translocates to the nucleus where it forms a complex with TCF/LEF transcription factors and activates Wnt target gene expression 28 , 29 . (nature.com)
However, the expression and function of microRNA-340-5p in lung cancer are still unknown. (ijpsonline.com)
Our study showed that the expression of microRNA-340-5p in lung cancer tissues and was significantly lower than normal tissues. (ijpsonline.com)
The expression of this gene is decreased in a variety of cancer cell lines and it may function as a tumor suppressor gene. (novusbio.com)

There are also various intracellular signal transmission pathways known to be active or inactive in cancer. (harvard.edu)

Abnormal activation of the Wnt cascade leads to carcinogenesis [ 10 , 11 ]. (hindawi.com)
The Wnt cascade consists of canonical and non-canonical pathways, of which the former is believed to be involved in self-regeneration. (hindawi.com)
The Wnt signaling pathway is a cascade of chemical reactions often dysregulated in cancer. (unige.ch)

A new research paper was published in Oncotarget's Volume 14 on May 26, 2023, entitled, "Deconstructing the role of MALAT1 in MAPK-signaling in melanoma: insights from antisense oligonucleotide treatment. (news-medical.net)
This was a well-performed trial of adjuvant therapy with dabrafenib (BRAF inhibitor) plus trametinib (MEK inhibitor) in patients with resected stage IIIA, IIIB, and IIIC melanoma by the American Joint Committee on Cancer (AJCC) 7th edition criteria. (medscape.com)
Jeffrey S. Weber, MD, PhD, is deputy director of the Laura and Isaac Perlmutter Cancer Center at NYU Langone Medical Center and co-director of its Melanoma Research Program. (medscape.com)
Malignant melanoma is a highly aggressive tumor type, in which Wnt signaling is essential. (lu.se)
Our studies show that the secreted Wnt modulator, SFRP3 is down-regulated in malignant melanoma patients. (lu.se)
Activation of Wnt5a signaling in melanoma cell lines resulted in a pro-tumorigenic effect by favoring aerobic glycolysis. (lu.se)
Taken together these data suggests that, in melanoma, an altered Wnt5a signal can induce different pro-tumorigenic effects. (lu.se)

Boudou C, Mattio L, Koval A, Soulard V and Katanaev VL (2022), Wnt-pathway inhibitors with selective activity against triple-negative breast cancer: From thienopyrimidine to quinazoline inhibitors. (unige.ch)

Breakage of the stem cell signaling network leads to carcinogenesis. (aacrjournals.org)

Interestingly, AURKA has been shown to further enhance Wnt and Ras-MAPK signalling. (vu.nl)
An activating hotspot mutation occurs at V600E and results in constitutive MAPK signalling and uncontrolled cellular growth. (hindawi.com)

WNT signals are transduced to the canonical pathway for cell fate determination, and to the noncanonical pathway for control of cell movement and tissue polarity. (aacrjournals.org)
Elevated AHNAK contents in ovarian cancer cell lines remarkably repressed ovarian cancer cell growth, along with metastasis in vitro, as well as in vivo. (aging-us.com)
The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
Frequently rearranged in advanced T‑cell lymphomas‑1 demonstrates oncogenic properties in prostate cancer. (nih.gov)
In addition, C57BL mice were injected with the human gastric cancer cell line HGC27 and its effect on bone mass was analyzed by Micro-CT, immunoblotting, and immunohistochemistry. (aging-us.com)
This book discusses the development and trends in the field of cancer stem cell research, with emphasis on colon cancer stem cells. (novapublishers.com)
We observed that the region-specific cell identity has a substantial effect on the reaction to Wnt activation in a simple intestinal adenoma model. (biomedcentral.com)
It is speculated that the cell of origin, i.e. the normal cell that acquires the first cancer-promoting mutation, might have a profound impact as well [ 17 ]. (biomedcentral.com)
In this study, the cytotoxicity effects of L. rhamnosus supernatant and whole-cell culture on a cancer cell line (Kyse30) compared to 5fu were evaluated by the MTT assay. (hindawi.com)
This cancer is divided into two types: (1) squamous cell carcinoma, which appears in the middle or top of the esophagus and (2) adenocarcinoma, seen in the glandular cells of the esophagus [ 1 ]. (hindawi.com)
Molecular subtypes of small cell lung cancer: a synthesis of human and mouse model data. (cancerindex.org)
Small cell lung cancer (SCLC) is an exceptionally lethal malignancy for which more effective therapies are urgently needed. (cancerindex.org)
IL-1, a family of cytokines, are involved in response to injury and infection, with IL-1 β playing a key role in cancer cell growth and the stimulation of CSCs. (beforeitsnews.com)
HBP1, an HMG Box transcription factor, is a cell cycle inhibitor and a transcriptional repressor of the Wnt signaling pathway. (tufts.edu)
Studies have shown that the Wnt/β-catenin signaling pathway controls cell fate and function through the transcriptional and post-translational regulation of omics networks. (frontiersin.org)
The lung cancer cell lines of human lung squamous cell carcinoma cell line SKMES1, human lung adenocarcinoma cell line A549, lung adenocarcinoma cells H23, human lung cancer cell line SPC-A1 and human squamous cell carcinoma H520 were used in present study. (ijpsonline.com)
They screened thousands of compounds and, after validation and further characterization, they were able to identify an interesting small molecule able to block the pathway in a triple-negative breast cancer cell line(compound 4a in the Figure below). (unige.ch)
To uncover genetic dependencies in breast cancer cells that harbor active β-catenin signaling, we performed RNAi-based loss-of-function screens in breast cancer cell lines in which we had characterized β-catenin activity. (plos.org)
However, the role of m6A in non-small cell lung cancer (NSCLC) is still unclear. (bvsalud.org)

The Wnt pathway is one of the most critical signaling pathways activated by mutation in many cancers [ 7 - 9 ]. (hindawi.com)
Recent studies have also found that presence of the BRAF mutation has direct implications for clinical management as along with TNM stage, BRAF mutational status was the only molecular variable that independently accounted for poor survival [ 13 ], and studies have found that BRAF mutant cancers are refractory to anti-EGRF therapy [ 14 , 15 ]. (hindawi.com)

Glypican-3 (GPC3) is upregulated in A2780cis cells in response to LMWH treatment, probably as counter-regulation to sustain the high Wnt activity against LMWH. (oncotarget.com)
Therefore, precise regulation of Wnt/β-catenin signaling as a cancer-targeting strategy may contribute to the treatment of some malignancies. (frontiersin.org)
Here, we review the complex regulation of Wnt/β-catenin signaling by SUMOylation and discuss the potential targets of SUMOylation therapy. (frontiersin.org)
In recent years, emerging studies have highlighted the critical role of these pathways and their regulation by microRNAs (miRNAs) in cancer invasion and metastasis. (intechopen.com)
It has been shown that inflammatory cytokines, such as TNF-α, IL-1β, IFNγ, are potential mediators in the regulation of Wnt-signaling. (umass.edu)

The SHH-subgroup accounts for 30% of medulloblastoma cases in children and is characterized by aberrant activation of the Sonic hedgehog (SHH) signaling pathway. (medscape.com)

We demonstrate that a direct interaction between the methyl-CpG-dependent transcription repressor Kaiso and xTcf3, a transducer of the Wnt signalling pathway, results in their mutual disengagement from their respective DNA-binding sites. (biologists.com)

More generally, these observations delineate an approach that can be used to identify druggable synthetic lethal interactions with signaling pathways that are frequently activated in cancer but are difficult to target with the currently available small molecule inhibitors. (plos.org)
In addition, our analyses also reveal the structural basis for TNKS substrate recruitment, and shed light on the overall structure of TNKS that should help in developing specific inhibitors of Wnt/β-catenin signaling. (rcsb.org)

Wnt/β-catenin signaling is a delicate and complex signal transduction pathway mediated by multiple signaling molecules, which plays a significant role in regulating human physiology and pathology. (frontiersin.org)

Aberrant activation of the Wnt signaling pathway is an important step in the initiation and progression of tumor development in diverse cancers. (nih.gov)
Generally speaking, signal transduction pathways in the initiation and progression of cancer are essential. (hindawi.com)
Proteins associated with the Wnt/β-catenin pathway have been identified as SUMOylated substrates, and evidences suggested that the initiation and progression of cancers depended on the function of the SUMOylation ( 23 ). (frontiersin.org)
Tumor initiation, development, and relapse may be closely associated with cancer stem cells (CSCs). (nature.com)

Instead, we propose that mutual inhibition by Kaiso/TCF3 of their DNA-binding functions may be important in developmental or cancer contexts and acts as a regulatory node that integrates epigenetic and Wnt signalling pathways. (biologists.com)
Epigenetic Alteration of the Cancer-Related Gene TGFBI in B Cells Infected with Epstein-Barr Virus and Exposed to Aflatoxin B1: Potential Role in Burkitt Lymphoma Development. (who.int)

The WNT-subgroup, which accounts for 10% of medulloblastoma cases in children, is characterized by aberrant activation of the Wingless (WNT) signaling pathway. (medscape.com)

A better understanding of how the two pathways interact could help identify an underlying cause of breast carcinogenesis. (eurekalert.org)

Gastric cancer, a highly invasive and aggressive malignancy, is the third leading cause of death from cancer worldwide. (oncotarget.com)
In summary, AURKA is a potential therapeutic target in gastric cancer and induces EMT through histone methylation. (oncotarget.com)
The miR-3648/FRAT1-FRAT2/c-Myc negative feedback loop modulates the metastasis and invasion of gastric cancer cells. (nih.gov)
However, whether primary or non-bone metastatic gastric cancer induces bone loss remains unclear. (aging-us.com)
Here, we collected clinical evidence of bone loss by analyzing serum and X-rays of 25 non-bone metastatic gastric cancer patients. (aging-us.com)
These indicated that gastric cancer could damage bone tissue before the occurrence of bone metastases. (aging-us.com)
In summary, our results suggest that gastric cancer cells might cause bone damage prior to the occurrence of bone metastasis via cilia-dependent activation of the Wnt/β-catenin signaling pathway. (aging-us.com)
While bone loss is likely to occur during the early stages of gastric cancer, it has largely remained undetected and has therefore not caused much concern. (aging-us.com)
The occurrence of cancer-associated bone disease may be due to the direct or systemic action of the gastric cancer itself during the treatment of the primary tumor. (aging-us.com)
Bone loss is associated with localized effects of metastatic deposits in the bone and/or systemic bone loss caused by bone resorption hormones or cytokines released into the systemic circulation by the gastric cancer [ 1 ]. (aging-us.com)
Once bone metastases occur, gastric cancer-induced osteoclast activation and bone resorption can proceed at a dangerously high rate resulting in the development of bone lesions that cause considerable pain and morbidity in patients [ 3 ]. (aging-us.com)
However, the phenomenon of bone loss caused by gastric cancer has not received enough clinical attention, and its molecular mechanism and optimal treatment strategy are still unknown. (aging-us.com)
In this study we focus on bone loss during the early stages of gastric cancer development before the occurrence of bone metastasis. (aging-us.com)

Integrated Analysis of Genetic Abnormalities of the Histone Lysine Methyltransferases in Prostate Cancer. (cancerindex.org)
The role of HMT gene variants in prostate cancer remains unknown. (cancerindex.org)
A 2020 study found that K3 has "potent anticancer activity" for some cancers of the breast, kidneys, liver, prostate, skin, and cervix. (greatist.com)
includes prostate cancer, for which generation" [11]. (who.int)
In addition, obesity is associated with progression (but not incidence) of tumour microenvironment through prostate cancer. (who.int)

These cells interact with tumor cells, via common signaling, and induce inflammation and immunosuppression locally in the tumor, but also systemically. (lu.se)

Noncanonical WNT signals are transduced through Frizzled family receptors and ROR2/RYK coreceptors to the Dishevelled-dependent (Rho family GTPases and c-jun NH 2 -terminal kinase) or the Ca 2+ -dependent (NLK and nuclear factor of activated T cells) signaling cascades. (aacrjournals.org)
Landscape of WNT signaling cascades. (aacrjournals.org)
Noncanonical WNT signals are transduced through Frizzled family receptors and ROR2/RYK coreceptors to the DVL-dependent (Rho family GTPases and JNK) or the Ca 2+ -dependent (NLK and NFAT) signaling cascades. (aacrjournals.org)

The activity of Wnt and Akt signaling pathways affected the level of histone methylation significantly, and we supposed that MLN8237 affected the level of histone methylation through these two signaling pathways. (oncotarget.com)
Methylation-based markers of aging and lifestyle-related factors and risk of breast cancer: a pooled analysis of four prospective studies. (who.int)

Thus, clarifying the precise mechanism of BCSCs self-renewal and identifying novel targets for effective intervention of breast cancer is urgently needed. (nature.com)

Abnormally activated Wnt/β-catenin signaling pathway plays a crucial role in promoting malignant tumor occurrence, development, recurrence, and metastasis, particularly in cancer stem cells. (frontiersin.org)
MicroRNA-340-5p is abnormally expressed in several cancers and plays an important role. (ijpsonline.com)

IC 50 values indicate the concentrations needed to reach 50% inhibition of the signal. (unige.ch)

We also found that cilia formation of MSCs was increased in the presence of HGC27 cells, which was associated with abnormal activation of the Wnt/β-catenin pathway. (aging-us.com)
These are transformed to resemble adenomas after Wnt activation through lentiviral transduction with a stable form of β-Catenin. (biomedcentral.com)
Abnormal activation of this pathway plays an essential role in chemoradiotherapy resistance ( 12 ). (frontiersin.org)
FTO was identified as a contributor to NSCLC metastasis through the activation of the FAP/integrin/FAK signaling, which may be a potential therapeutic target for NSCLC. (bvsalud.org)
We found that Wnt5a could activate regulated secretion of IL-6 and VEGF, dependent on cytoskeletal re-arrangements mediated via calcium signaling and Cdc42 activation. (lu.se)

Low molecular weight heparin (LMWH), the guideline based drug for prophylaxis and treatment of cancer-associated thrombosis, was recently shown to sensitize cisplatin resistant A2780cis human ovarian cancer cells for cisplatin cytotoxicity upon 24 h pretreatment with 50 μg × mL -1 of the LMWH tinzaparin in vitro , equivalent to a therapeutic dosage. (oncotarget.com)
Using TCF/LEF luciferase promotor assay (Top/Flash) we show that resistant A2780cis cells possess a threefold higher Wnt signaling activity compared to A2780 cells. (oncotarget.com)
Consequently, Wnt signaling pathway appears as primary target of LMWH in sensitizing A2780cis cells for cisplatin toxicity. (oncotarget.com)
Knockdown of FRAT1 inhibits hypoxia-induced epithelial-to-mesenchymal transition via suppression of the Wnt/β-catenin pathway in hepatocellular carcinoma cells. (nih.gov)
The Wnt signaling pathway creates a complex network of proteins that have different effects on cells, so they can be involved in many cancers, including gliomas. (researchsquare.com)
The Wnt signaling pathway creates a complex network of proteins that have different effects on cells. (researchsquare.com)
Recently, cancer stem cells have emerged as an exciting new concept in cancer research. (novapublishers.com)
A new study finds turmeric extract selectively and safely killing cancer stem cells in a way that chemo and radiation can not. (beforeitsnews.com)
This pathway plays a key role in regulating normal stem cells, with aberrant signaling stimulating CSCs, resulting once again in tumor recurrence and resistance to chemotherapy. (beforeitsnews.com)
Here, we aimed at identifying a β-catenin-independent Wnt target gene signature in order to understand the functional significance of non-canonical signaling in colon cancer cells. (nature.com)
Cancer cells depart their normal microenvironment from the primary tumor site through complicated and multistep processes disseminate and colonize distant organs [ 1 ]. (intechopen.com)
In adult tissues, this pathway plays a role in the maintenance and renewal of stem cells, which are cells that help repair tissue damage and can give rise to other types of cells. (medlineplus.gov)
The vast majority of breast cancers are carcinomas that originate from cells lining the milk-forming ducts of the mammary gland. (genome.jp)
These models can be used to answer how tumors respond to new cancer treatments, how current treatment works in tune with new treatments, and provide detailed knowledge of specific interactions between the tumor and surrounding cells. (lu.se)
In the USA, obesity has recent- obesity is associated with progres- aberrations of cancer cells, summa- ly surpassed tobacco use as the sion but not incidence [9]. (who.int)

At the crossroads of fertility and metabolism: the importance of AMPK-dependent signaling in female infertility associated with hyperandrogenism. (who.int)

Thus, targeting signal molecules can be helpful for cancer therapy [ 6 ]. (hindawi.com)
Conceptually, it is an efficient way to treat cancer involved the hijacking of PTMs of the key molecules in Wnt/β-catenin. (frontiersin.org)
Researchers from the laboratory of Prof. Vladimir Katanaev used an interdisciplinary approach combining both chemistry and biology to find novel small molecules inhibiting the Wnt signaling pathway. (unige.ch)

An herbal formula inhibits STAT3 signalling and attenuates bone erosion in collagen-induced arthritis. (greenmedinfo.com)

Axin1 and GSK3β are recruited to the receptor complex upon Wnt stimulation and this leads to a breakdown of the destruction complex and β-catenin stabilization. (nature.com)
Hormone receptor positive breast cancers are largely driven by the estrogen/ER pathway. (genome.jp)

Consequently, antithrombotic prophylaxis is an important component in the therapeutic regimens of cancer patients. (oncotarget.com)
CCR5 blockage by maraviroc: a potential therapeutic option for metastatic breast cancer. (cancerindex.org)
Wnt/- Catenin Signaling Pathway Function in Uterine Leiomyoma: Potential for Therapeutic Intervention. (tufts.edu)
The discovery of new agents capable of inhibiting it would provide novel therapeutic approaches to treat cancer. (unige.ch)
These promising findings open up new avenues to broaden therapeutic options against triple-negative breast cancer. (unige.ch)
These studies identify CK1ε as a critical contributor to activated β-catenin signaling in cancer and suggest it may provide a potential therapeutic target for cancers that harbor active β-catenin. (plos.org)
In order to resist cancer dissemination, more effective therapeutic strategies are clearly required. (intechopen.com)
Lnc408-CBY1-β-catenin signaling axis might serve as a new diagnostic and therapeutic target for breast cancer. (nature.com)

This review will explore our current understanding of BRAF mutant cancers with respect to presence or absence of MSI. (hindawi.com)

In the case of breast cancer only 8% of all cancers are hereditary, a phenomenon linked to genetic changes in BRCA1 or BRCA2. (genome.jp)

Recent reports based on proteomic studies have identified many SUMOylated substrates that play important roles in the development and progression of cancer. (frontiersin.org)
One such disease process is the development and progression of cancer. (lu.se)

Anatomy14

Organisms5

Diseases45

Chemicals and Drugs73

Analytical, Diagnostic and Therapeutic Techniques and Equipment61

Psychiatry and Psychology1

Phenomena and Processes48

Disciplines and Occupations2

Anthropology, Education, Sociology and Social Phenomena2

Humanities1

Information Science7

Named Groups2

Health Care28

Geographicals3

Genes24

Notch10

Colorectal22

Canonical WNT8

Regulates5

Proliferation20

Protein15

Beta-catenin signali1

Embryonic3

Evolutionarily conserved2

Mutations7

Differentiation2

Inhibit4

Consists of 19 members1

Ligands3

Regulator2

Mechanisms6

Expression10

Intracellular1

Cascade3

Melanoma7

20221

Leads to carcinogenesis1

MAPK2

Cell19

Mutation2

Regulation5

Hedgehog1

Transcription1

Inhibitors2

Transduction pathway1

Initiation4

Epigenetic2

Aberrant activation1

Carcinogenesis1

Gastric cancer13

Prostate5

Tumor cells1

Cascades3

Methylation2

Targets1

Abnormally2

Inhibition1

Activation5

Cells15

Metabolism1

Molecules3

STAT31

Receptor2

Therapeutic8

Absence1

Genetic1

Progression of cancer2