Cancer tumor cell proliferation growth of tumor cells cell cycle. Medical search. Frequent questions

Propidium iodide staining and flow cytometry analysis of Annexin V binding was utilized to measure the progression of the cell cycle and the induction of apoptosis. (techscience.com)
Abstract Fos-related antigen 1 (Fra-1) is a nuclear transcription factor that regulates cell growth, differentiation, and apoptosis. (techscience.com)
It is involved in the proliferation, invasion, apoptosis and epithelial mesenchymal transformation of malignant tumor cells. (techscience.com)
Fra-1 is highly expressed in gastric cancer (GC), affects the cycle distribution and apoptosis of GC cells, and participates in GC occurrence and development. (techscience.com)
Cell cycle distribution and apoptosis were detected using flow cytometry. (hindawi.com)
10 mg/mL) of Nidus Vespae decoction (NVD) inhibited SGC-7901 gastric cancer cell growth by inducing G2/M cell cycle arrest and apoptosis. (hindawi.com)
Furthermore, the supernatant of THP-1 DCs significantly inhibited the proliferation of gastric cancer cells by inducing apoptosis and G1/S cell cycle arrest. (hindawi.com)
They can trigger apoptosis, a process of programmed cell death, when a cell becomes irreparably damaged or poses a risk of becoming cancerous. (pharmiweb.com)
miRNA-149 was underexpressed in gastric cancer tissues and cells, while overexpression of miRNA-149 promoted cell apoptosis, retarded cell cycle, and inhibited proliferation and migration in AGS and MKN28 cells. (hindawi.com)
As a consequence, any modulations of the target transcript expression, miRNAs can affect various signalling pathways and cellular process such as apoptosis, proliferation or differentiation. (ukessays.com)
Although the conventional activities of p53 such as cell cycle arrest, senescence, and apoptosis are well accepted as the major checkpoints in stress responses, accumulating evidence implicates the importance of other tumor suppression mechanisms. (nature.com)
Is p53-dependent ferroptosis sufficient for tumor suppression in the absence of cell cycle arrest, senescence, and apoptosis? (nature.com)
To date, various mechanisms have been suggested to explain the powerful tumor-suppressive effect of p53, including the induction of cell cycle arrest, senescence, and apoptosis. (nature.com)
The TP53 gene plays an important role in regulating the cell cycle, apoptosis and DNA damage repair ( 8 , 9 ). (spandidos-publications.com)
Wild-type TP53 can inhibit the cell cycle and activate apoptosis-related genes that induce apoptosis and regulate cell proliferation ( 10 ). (spandidos-publications.com)
Of note, an increased carbohydrate uptake and/or induction of death receptors of cancer cells was exploited to develop glycoconjugates that potentially induce cellular stress, ROS and apoptosis. (degruyter.com)
ASncmtRNA knockdown with an antisense oligonucleotide induces massive apoptosis in tumor cell lines, without affecting healthy cells. (uandes.cl)
This effect is mediated by downregulation of the key cell cycle progression factors cyclin B1, cyclin D1, CDK1, CDK4, and survivin, the latter also constituting an essential inhibitor of apoptosis, underlying additionally the onset of apoptosis. (uandes.cl)
This work adds to the elucidation of the molecular mechanisms behind cell cycle arrest preceding tumor cell apoptosis induced by ASncmtRNA knockdown. (uandes.cl)
Flow cytometry was used to examine apoptosis, cell cycle distribution, and accumulation of reactive oxygen species (ROS). (jcancer.org)
Moreover, it induced cell cycle arrest in the G0/G1 phase, apoptosis, and ROS generation in these cells. (jcancer.org)
Silibinin considerably reduced the development of oral cancer cells by inducing apoptosis, G 0 /G 1 arrest, ROS generation, and activation of the JNK/c-Jun pathway. (jcancer.org)
In 4T1 breast cancer cells, short-term starvation resulted in increased phosphorylation of the stress-sensitizing Akt and S6 kinases, increased oxidative stress, caspase-3 cleavage, DNA damage, and apoptosis. (kingdomfasting.com)
Apoptosis was measured by Hoechst 33258/propidium iodide double staining of nuclear chromatin and the formation of gaps into the lymphendothelial barrier in a three-dimensional co-culture model consisting of MCF-7 tumour cell spheroids and human lymphendothelial monolayers. (nature.com)
In HL-60 leukaemia cells, di-GA activated caspase 3 and dose-dependently induced apoptosis. (nature.com)
These data show that di-GA exhibits three distinct anticancer activities: induction of apoptosis, cell-cycle arrest and disruption of cancer cell-induced lymphendothelial disintegration. (nature.com)
it inhibits cell migration, reduces the ability to form colonies and induces apoptosis or programmed cell death through the modulation of other key genes (p53, caspase-3, c-PARP) and various apoptotic factors," says Maurizio Battino, coordinator of the research. (agenciasinc.es)
It also suppresses the receptor of the epidermal growth factor called EGFR/HER2 and its signalling pathways, which could be an attractive target in cancer therapies because of their important role in the processes of cell survival and proliferation, as well as in those of apoptosis and metastasis. (agenciasinc.es)
At UIC the inventor found that mammalian BARA (β- subunit Associated Regulator of Apoptosis)/LIN-9 is a predominantly nuclear protein that inhibits cell proliferation. (univation.co)
ZOL effects were studied in vivo on bone lesion development and in vitro on AT6-1 cell proliferation, apoptosis and cell cycle analysis. (whiterose.ac.uk)
Studied extensively, ginsenosides display anticancer and anti-metastatic properties - not only by restricting cancer cell proliferation, viability, invasion and migration, but also by promoting apoptosis (cell death) or paraptosis (a new and unique cell death mode), cell cycle arrest and autophagy (the body's process of reusing old and damaged cell parts) in several cancers, such as brain, breast, gastric, liver and lung cancer. (girlsfeel.com)
Researchers in a study from the Journal of Ginseng Research reported that in glioblastoma multiforme (GBM) - the most common primary malignant brain tumor in adults and a challenging disease to be treated - ginsenoside F2 induced glioma stem cells, including CD133 cells (one of the most well-characterized biomarkers used for the isolation of cancer stem cells), to commit apoptosis and inhibit new blood cells from forming. (girlsfeel.com)
One study from September 2023 published in Frontiers in Pharmacology updated the therapeutic role of ginsenosides in breast cancer treatment and summarized its mechanisms of action, which include inducing apoptosis, autophagy, inhibiting epithelial-mesenchymal transition (EMT) and metastasis, and regulating miRNA and lncRNA. (girlsfeel.com)
these oncomodulatory viruses can alter the pathology of these tumors by affecting cell signaling, cell metabolism, apoptosis mechanisms, cell-cell communication, inflammation, antitumor immunity suppression, and angiogenesis. (surgicalneurologyint.com)
Oncomodulation is a process, whereby tumor behavior is affected by virally induced mechanisms acting on cancer cells as well as stromal cells within the tumor microenvironment, including suppression of cancer cell apoptosis mechanisms, altering tumor metabolism, suppressing antitumor immunity, triggering tumor microenvironment inflammation, initiating angiogenesis, stimulating tumor cell proliferation, increasing tumor invasion, and enhancing tumor cell migration (metastasis) [ Figures 1 and 2 ]. (surgicalneurologyint.com)
Another mechanism is up-regulation of pathways that inhibits cell apoptosis. (oncologynurseadvisor.com)
Since BCL2, a protein that indirectly inhibits cell apoptosis, is required for certain chemotherapies to work, the absence of BCL2 obscures their uses in prostate cancer. (oncologynurseadvisor.com)
70 Mcl1 (myeloid cell leukemia differentiation protein 1) and other members of the BCL family, such as BCL-xl (B-cell lymphoma-extra-large), are also involved in resistance to Interleukin (IL)-6, stromal cell derived factor-1, and cytokine-induced apoptosis. (oncologynurseadvisor.com)
71 Clusterin is a small heat shock glycoprotein overexpressed in most of the solid tumors, which promotes apoptosis by binding to various molecules such as BAX (BCL2-associated X protein) 72 and signal transducer and activator of transcription (STAT)−1. (oncologynurseadvisor.com)
75,76 Tumor necrosis factor (TNF)-α inhibits apoptosis by activating NF-κB and its downstream pathway, including IL6 and IL8, in androgen-independent prostate cancer cells, whereas it promotes apoptosis in androgen-dependent cancer cells. (oncologynurseadvisor.com)
Our objective was to evaluate the effect of the COX-2 inhibitor, celecoxib, on (1) proliferation and apoptosis in human ovarian cancer cell lines and primary cultures of ovarian cancer cells, and (2) inhibition of tumor growth in a genetically engineered mouse model of serous ovarian cancer under obese and non-obese conditions. (houstonmethodist.org)
Treatment with celecoxib resulted in G1 cell cycle arrest, induction of apoptosis, inhibition of cellular adhesion and invasion and reduction of expression of hTERT mRNA and COX- 2 protein in all of the ovarian cancer cell lines. (houstonmethodist.org)
In the ovarian tumors from obese and non-obese KpB mice, treatment with celecoxib as compared to control resulted in decreased proliferation, increased apoptosis and reduced COX-2 and MMP9 protein expression, as assessed by immunohistochemistry. (houstonmethodist.org)
recruits CD8+ T cells, granulocytes, and macrophages to the infection area and induces the release of TNF-related apoptosis-inducing ligand (TRAIL) from neutrophils. (metabiom.org)
Once in the tumor, S. typhimurium continues to proliferate and directly kills cancer cells by triggering of apoptosis, necrosis, and cell rupture. (metabiom.org)

Together, these results indicate epigenetic loss of BCO2 expression is associated with prostate cancer progression. (nih.gov)
Moreover, TSPAN12 accelerated mitotic progression by controlling cell cycle. (molcells.org)
in fact, it may promote the progression of cancer. (hindawi.com)
Studies [ 13 - 15 ] have shown that miR-149 plays an important role in many cancers, although its regulatory role in the FOXC1-mediated progression of gastric cancer remains unclear. (hindawi.com)
T he presence and activity of various proteins are required in the cell cycle progression. (ukessays.com)
This miRNA functions as a tumor suppressor and dysregulation or loss of the host gene from which this miRNA is processed is associated with cancer progression in numerous cell types. (cancerindex.org)
A vast amount of research exists on the possible molecular mechanisms through which vitamin D affects cancer cell proliferation, cancer progression, angiogenesis, and inflammation. (mdpi.com)
Here, cycles of fasting for 2 days in the absence of other treatments are shown to delay the progression of several tumor types in mice and, in some cases, to be as effective as toxic chemotherapy drugs. (kingdomfasting.com)
However, the combination of fasting and chemotherapy was much more effective than either alone and delayed the progression of a variety of tumors, including breast cancer and glioma, reduced the number of organs affected by melanoma metastases, and promoted long-term cancer-free survival in up to 40% of mice with neuroblastomas. (kingdomfasting.com)
In mice injected with human breast and ovarian cancer cells, fasting cycles promoted survival extension by protecting the mice from chemotherapy while causing a strong inhibition of tumor progression. (kingdomfasting.com)
Cycles of starvation were as effective as chemotherapeutic agents in delaying progression of different tumors and increased the effectiveness of these drugs against melanoma, glioma, and breast cancer cells. (kingdomfasting.com)
Also, DR only retards the progression of specific cancers, possibly because of its relatively small effect on glucose and growth factors (7, 8). (kingdomfasting.com)
It further inhibited cell-cycle progression in the G1 phase by four different mechanisms: rapid downregulation of cyclin D1, induction of Chk2 with simultaneous downregulation of Cdc25A, induction of the Cdk-inhibitor p21 Cip/Waf and inhibition of ribonucleotide reductase activity resulting in reduced dCTP and dTTP levels. (nature.com)
The study identified 2 genes known to contribute to tumor progression and 8 known to be present in tumor cells but which have unknown functions. (frontiersin.org)
This specific project aims to identify sequences within caveolin involved in regulation of raft internalisation, cell cycle progression and anchorage-dependent cell growth. (europa.eu)
This objective integrates into a bigger project that also aims to identify molecular mechanisms by which caveolin regulates anchorage-dependent signalling pathways and cell cycle progression and to identify oncogenes that induce constitutive surface localization of rafts (and hence Rac), and/or changes in phosphocaveolin localization. (europa.eu)
While some patients experience spontaneous regression or differentiation of the tumor, others are affected by rapid and fatal tumor progression despite increasingly intensive treatment strategies [ 9 ]. (biomedcentral.com)
proteasome inhibition interferes with cell cycle progression, upregulates tumor suppressors such as p53, and diminishes activation of pro-proliferation pathways such as those controlled by NFB and extracellular signal-regulated kinases (ERKs) [3], [4]. (scienza-under-18.org)
Our study uncovered a novel molecular mechanism of lncRNA SNHG4 in driving prostate cancer progression and enzalutamide resistance, revealing the critical roles and therapeutic potential of RREB1, SNHG4, RRM2 and let-7 miRNAs in anticancer therapy. (biomedcentral.com)
The results showed that Ganoderma lucidum inhibits cell growth and disruption of cell cycle progression via down regulation of cyclin D1. (greenmedinfo.com)
During cell growth and proliferation, ubiquitin plays an outsized role in promoting progression through the cell cycle. (intechopen.com)
Progression through the cell cycle is driven by the oscillating activity of Cyclin Dependent Kinases (CDKs). (intechopen.com)
It is within the tumor microenvironment that myoblasts are linked to the progression of lung cancer. (phytid.org)
Although the involvement of myofibroblasts (MFs) in these tumor microenvironment has been studied and their contribution to tumor progression have been elucidated, the exact role of MFs in these complicated signaling cascades remains unclear. (phytid.org)
It is known that the interaction between MFs and lung cancer cells influences the formation and progression of lung cancer development3C5. (phytid.org)
Provided the stimulatory part of IL-6 on JAK/STAT signaling, IL-6/JAK/STAT3 signaling might be included in lung cancer progression. (phytid.org)
Epithelial-mesenchymal transition occurs when epithelial cells take about mesenchymal properties and is definitely essential for metastasis and progression of cancer. (phytid.org)
As such, pro-inflammatory cytokine signaling through JAK/STAT3 could become essential for the relationships between lung tumor cells and stromal cells in the modification of lung tumor cells to consider on stromal cell properties, which promote progression of lung result and cancer in poor prognosis14. (phytid.org)
Gaining CP-673451 a better understanding of the inflammatory signaling cascades in the discussion between lung tumor cells and MFs would aid in the development of approaches for inhibiting cancer progression. (phytid.org)
Chronic inflammation over the years results in altered immune responses and increases risk of tumor formation and progression. (metabiom.org)
Prediction of desmoid tumor progression using miRNA expression profiling. (medscape.com)

Oncogenes are responsible for cell proliferation and differentiation. (wikipedia.org)
This family, which includes epidermal growth factor receptor (EGFR), plays a pivotal role in normal cell growth, lineage determination, repair, and functional differentiation. (medscape.com)
The THP-1 DCs had significantly increased expression of cluster of differentiation 11c (CD11c), CD40, CD80, CD83, and CD86, as well as secretion of tumor necrosis factor-alpha. (hindawi.com)
It possesses a unique forkhead domain combined with a fragment of the target gene to initiate transcription [ 10 ] and regulates various biological processes such as tumor cell differentiation, cell proliferation, and migration [ 11 ]. (hindawi.com)
Let-7 Let-7 has an essential role in cell cycle and the differentiation of cell cycle terminals. (ukessays.com)
The positive rate of p53 protein expression was 54.5% (201/369) in the multi‑ethnic group, and was significantly different between sex (P=0.026) and between tumor differentiation groups (P=0.032). (spandidos-publications.com)
This protein also forms a core subunit of the nucleosome remodeling and histone deacetylation (NURD) complex that epigenetically regulates embryonic stem cell differentiation. (cancerindex.org)
For childhood neoplasms, it is safe to assume that cancer is the product of degeneration in a neoplastic sense of tissues undergoing very rapid proliferation and differentiation, in which proliferative and differentiative programs are being disturbed by increasingly early (maternal-fetal) exposure to a growing number of environmental stressors and pollutants. (frontiersin.org)
Through this role in regulating the activity (expression) of genes, the Dicer protein is involved in many processes, including cell growth and division (proliferation) and the maturation of cells to take on specialized functions (differentiation). (medlineplus.gov)
Cancer stem cells are a selective clonal subset of tumour cells that have avoided various cell regulatory mechanisms, including terminal differentiation, and yet have retained the self-renewal properties and proliferative potential of adult stem cells. (who.int)
Its prominent properties are A lack of cell differentiation Local invasion of adjoining tissue Metastasis, which is spread to distant sites through. (msdmanuals.com)

Some of the new approaches depend on tumor biology and aim specifically to inhibit tumor growth and metastasis by targeting the tumor microenvironment or vasculature (leaving normal cells unaffected) or focusing on specific protein or signal transduction pathways. (medscape.com)
Some tumor suppressor proteins are involved in maintaining cell adhesion, preventing cells from breaking away and spreading to other parts of the body (metastasis). (pharmiweb.com)
Dysregulation of these molecules can lead to various diseases, including cancer metastasis, autoimmune disorders, and developmental abnormalities. (pharmiweb.com)
Although valuable progress has been made in the treatment of NSCLC in previous years, the high metastasis rate, post-operative recurrence rate and resistance to chemotherapeutic drugs in lung cancer have led to unsatisfactory outcomes ( 4 , 5 ). (spandidos-publications.com)
Our previous study had identified the negative correlation between circHIPK3 and bladder cancer grade, invasion, as well as lymph node metastasis. (biomedcentral.com)
Bladder cancer (BC) is the number one malignancy of urinary system with an estimated over 79,030 deaths predicted in 2017 in the United State [ 1 ].The high rate of recurrence and distant metastasis of BC created a huge economic burden in EU [ 2 ]. (biomedcentral.com)
Overexpression of cyclophilins has been observed in HCC increasing proliferation, metastasis and promoting chemoresistance. (lu.se)
Although most circulating cancer cells die, an occasional cell may penetrate into tissues, generating a metastasis at a distant site. (msdmanuals.com)

Cancer cells obtain a growth advantage through uncontrolled cell proliferation ( Hanahan and Weinberg, 2011 ), which may be caused by mutations that help them adapt to the microenvironment through selective pressure. (molcells.org)
thus, glucose restrictions are imposed on nontumor cells in the PDAC tumor microenvironment (TME). (jci.org)
Understanding these connections inside the tumor microenvironment would contribute to unraveling new therapeutic targets. (biotech-angels.com)
We are also learning that much of the behavior of tumors depends on cancer stem cells and stromal cells within the tumor microenvironment, which participate in extensive, dynamic crosstalk known to affect tumor behavior. (surgicalneurologyint.com)
In a number of studies, it has been shown that while only a select number of cells are actually infected with the virus, numerous viral proteins are released into the cancer and stromal cells in the microenvironment and these viral proteins are known to affect tumor behavior and aggressiveness. (surgicalneurologyint.com)
Tumor cell proliferation, angiogenesis, and suppression of antitumor immune activity are enhanced in the face of tumor microenvironment inflammation. (surgicalneurologyint.com)
Activation of this factor occurs in the stromal cells, tumor cells, and invading immune cells within the tumor microenvironment. (surgicalneurologyint.com)

The mutated DNA affects genes involved with the cell cycle, classified as either oncogenes or tumor suppressor genes. (wikipedia.org)
Tumor suppressor genes prevent cells with erroneous cell cycles from replicating. (wikipedia.org)
This task can be accomplished by replacing tumor suppressor genes that have been lost or mutated, selectively inserting genes that produce cytotoxic substances, or modifying the immune system to destroy the tumor cells. (medscape.com)
Tumor suppressor genes code for proteins that inhibit cell division and growth, acting as a control mechanism to prevent excessive cell proliferation. (pharmiweb.com)
Tumor suppressor genes can promote cellular senescence, a state in which cells stop dividing, preventing the replication of damaged DNA. (pharmiweb.com)
miR-149 is a type of miRNA, which can regulate the biological functions of tumors by targeting multiple genes, such as TGF- β 2, GIT1, and HDAC4 [ 7 - 9 ]. (hindawi.com)
1) The alternation of protein levels of critical oncogenes or tumour suppressor genes, which causes by miRNAs deregulation may also lead to proliferative diseases such as cancer. (ukessays.com)
Besides cancer, some miRNAs genes cause or contribute in many inherited and genetic based diseases. (ukessays.com)
These 12 genes are located at a region, which is frequently deleted in cancer. (ukessays.com)
The tumor suppressor TP53 (also called p53) has been among the most extensively studied genes since its discovery in 1979 [ 1 , 2 ]. (nature.com)
Treatment with honey stops the tumour cells cycle by regulating some genes (cyclin D1, CDK2, p27Kip. (agenciasinc.es)
identified 189 frequently mutated genes associated with these cancers, most of which were not previously known. (frontiersin.org)
We investigated by real-time quantitative RT-PCR the expression profile of a panel of genes important in cell cycle regulation. (biomedcentral.com)
Interestingly, the 1p36 region is frequently deleted not only in NB, but also in other human cancer types, including those of neural, epithelial and hematopoietic origin, indicating that the same tumor suppressor genes might be involved in a broad range of human cancers [ 11 ]. (biomedcentral.com)
Bioinformatic analyzing approaches were used to identified the over-expressed genes in prostate cancer tumor tissues from three GEO datasets. (biomedcentral.com)
PGE2 activation of JAK2/STAT3 acting on genes controlling tumor invasion/migration, cell proliferation, angiogenesis, and initiating immune suppression is demonstrated. (surgicalneurologyint.com)
Aberrations of AR, erythroblast transformation-specific ( ETS ) genes, Tumor protein 53 (TP53), and Phosphatase and tensin homolog (PTEN) occurred in 40%-60% of 150 mCRPC cases in a recent study. (oncologynurseadvisor.com)
Without appropriate regulation by miRNA, genes are likely expressed abnormally, which could cause cells to grow and divide uncontrollably and lead to tumor formation. (medlineplus.gov)
The total chromosomal content of a cell involves approximately 105 genes in a specialized macromolecule of deoxyribonucleic acid (DNA). (cdc.gov)
This is an autosomally dominant germline mutation in DNA mismatch repair (MMR) genes ( MSH1 , MSH2 , MSH6 ) and accounts for 9% of patients younger than 50 years with endometrial cancer. (medscape.com)

Dogs can develop carcinomas of epithelial cells and organs, sarcomas of connective tissues and bones, and lymphomas or leukemias of the circulatory system. (wikipedia.org)
Here, we reported that mammalian target of rapamycin complex 2 (mTORC2) kinase is overexpressed in pancreatic cancer tissues and promotes pancreatic cancer cell growth and invasion. (techscience.com)
They facilitate adhesion between leukocytes and endothelial cells, enabling leukocyte extravasation into tissues during inflammation. (pharmiweb.com)
Ig-superfamily CADMs are involved in mediating cell-to-cell adhesion, helping cells stick together and form tissues and organs. (pharmiweb.com)
qRT-PCR was used to detect the expression of miRNA-149 and FOXC1 in gastric cancer tissues and cells. (hindawi.com)
Twenty pairs of gastric cancer and adjacent nontumor tissues, which were not subjected to radiotherapy or chemotherapy, were obtained from the First Affiliated Hospital of Xi'an Jiaotong University. (hindawi.com)
Can ferroptosis be specifically induced in tumors but not in normal tissues? (nature.com)
We had analyzed circRNA high-throughout sequencing from human tissues and determined bladder cancer related circRNA-3 (BCRC-3, GenBank: KU921434.1) as a new candidate circRNA derived from PSMD1 gene. (biomedcentral.com)
The expression levels of circRNAs, mRNAs and miRNAs in human tissues and cells were detected by quantitative real-time PCR (qRT-PCR). (biomedcentral.com)
BCRC-3 was lowly expressed in bladder cancer tissues and cell lines. (biomedcentral.com)
Instead of oral administration, probiotics can also be delivered locally at tumor sites, which can reduce non-specific pharmacological effects on non-tumor tissues. (metabiom.org)
Cyclophilin overexpression is a common event in fibrotic tissues playing a key role in different stages of the fibrotic process, including inflammation, hepatocyte death, and activation of the hepatic stellate cells leading to increased collagen production. (lu.se)
Local growth is facilitated by enzymes (eg, proteases) that destroy adjacent tissues. (msdmanuals.com)
Our finding of BLV in human tissues indicates a risk for the acquisition and proliferation of this virus in humans. (cdc.gov)

Carcinogenesis is linked with DNA mutations, chromosomal translocations, dysfunctional proteins, and aberrant cell cycle regulators. (wikipedia.org)
Many tumor suppressor proteins play a role in DNA repair, helping to correct genetic mutations and maintain the stability of the genome. (pharmiweb.com)
Mutations in TP53 can lead to the loss of these functions, inducing uncontrolled cell growth and the promotion of tumor development ( 11 , 12 ). (spandidos-publications.com)
piloted the use of NGS to study the exomes of 140 samples of human acute myeloid leukemia (AML) cells in 2003, identifying 6 previously described and 7 undescribed mutations relevant for AMP pathogenesis. (frontiersin.org)
Table 1 provides a summary of cancers and gene mutations. (frontiersin.org)
Caveolin sporadic mutations occurring in human cancers will be tested for these effects. (europa.eu)
Today's dominant paradigm in the field of carcinogenesis can be described as stochastic mutational, a model where cancer is ultimately viewed as the product of a slow accumulation of stochastic DNA mutations. (frontiersin.org)
The fact that cancer increases especially in the early years of life is something unexpected and difficult to explain with the model of slow accumulation of stochastic mutations. (frontiersin.org)
many people who have mutations in the DICER1 gene do not develop abnormal growths. (medlineplus.gov)
Genetic testing for germline mutations of the APC gene in patients with apparently sporadic desmoid tumors but a family history of colorectal carcinoma. (medscape.com)
These mutations lead to microsatellite instability in 90% of colon cancers and 75% of endometrial cancers. (medscape.com)

Cell adhesion molecules are a diverse group of proteins that play a crucial role in mediating cell-to-cell interactions and cell-to-extracellular matrix interactions. (pharmiweb.com)
Our results suggest that ASncmtRNA targeting blocks tumor cell proliferation through reduction of essential cell cycle proteins, mediated by mitochondrial and nuclear miRNAs. (uandes.cl)
Furthermore, silibinin inhibited the migration and invasion abilities of YD10B and Ca9-22 cells by regulating the expression of proteins involved in the epithelial-mesenchymal transition. (jcancer.org)
In addition, proteome analysis of NBPF1-overexpressing DLD1 cells identified 32 differentially expressed proteins, of which several are implicated in carcinogenesis. (biomedcentral.com)
We demonstrated that NBPF1 exerts different tumor suppressive effects, depending on the cell line analyzed, and provide new clues into the molecular mechanism of the enigmatic NBPF proteins. (biomedcentral.com)
The ubiquitin-proteasome pathway is an essential quality control mechanism directing degradation of mislocated, misfolded, and damaged proteins, and, by tempering the expression levels Carnosol of specific signaling proteins, it also exerts a level of control over cell physiology [1]. (scienza-under-18.org)
ERK signaling is usually inappropriately activated in a wide array of human cancers, which can be caused by an activating mutation in one of the upstream signaling proteins or through overexpression of growth factors or growth factor receptors [7], [8]. (scienza-under-18.org)
Considering that a host of intracellular proteins are affected by proteasome inhibition, coupled with evidence that knockdown of MKP3 expression enhances growth factor-stimulated ERK phosphorylation in some contexts [13] but not in others [16], led us to question whether or not the diminution of ERK signaling in MG132-treated cells could be attributed solely to upregulation of MKP3 and other DUSPs. (scienza-under-18.org)
Tumor cell growth, proliferation, cell cycling and expression of cell cycle regulating proteins were then evaluated. (biotech-angels.com)
Oncomodulatory viruses, such as human cytomegaloviruses (HCMV), are known to release over 200 proteins, many of which can alter tumor behavior [ Table 1 ]. (surgicalneurologyint.com)
NCMV proteins and their oncogenic effects on cell mechanisms. (surgicalneurologyint.com)
Rather, only a few cells need to be infected, with the release of viral proteins from the viruses, which occupy most if not all of the tumor cells, including stromal cells. (surgicalneurologyint.com)
Cells depend on their DNA for coding information to make various classes of proteins that include enzymes, certain hormones, transport proteins, and structural proteins that support life. (cdc.gov)
Specialized cell structures called ribosomes are the cellular organelles that actually synthesize the proteins (RNA transcription). (cdc.gov)

Targeted molecular therapy against EGFR has shown promise as an adjuvant therapy in preliminary studies in several solid tumors, including head and neck cancer. (medscape.com)
People with DICER1 syndrome are also at risk of multinodular goiter, which is enlargement of the thyroid gland caused by the growth of multiple fluid-filled or solid tumors (both referred to as nodules). (medlineplus.gov)

It is reported that FOXC1 plays an important role in the occurrence, development, and migration of malignant tumors [ 12 ]. (hindawi.com)
Esophageal cancer is one of the most common malignant tumors. (spandidos-publications.com)
Oral cancer is one of the most prevalent malignant tumors worldwide. (jcancer.org)

Notably, restoring bco2 expression in prostate cancer cells inhibited cell proliferation and colony formation, irrespective of lycopene exposure. (nih.gov)
Further exploration showed that TSPAN12 overexpression accelerated proliferation and colony formation of OVCAR3 and SKOV3 OC cells. (molcells.org)
Knockdown of TSPAN12 expression in A2780 and SKOV3 cells decreased both proliferation and colony formation. (molcells.org)
The MTT, colony formation, flow cytometry, wound healing, transwell, and western blotting were performed to examine the function of miRNA-149 and FOXC1 in the development of gastric cancer. (hindawi.com)
To investigate the effects of silibinin on the growth of oral cancer cells, cell proliferation and anchorage-independent colony formation tests were conducted on YD10B and Ca9-22 oral cancer cells. (jcancer.org)
Silibinin effectively suppressed YD10B and Ca9-22 cell proliferation and colony formation in a dose-dependent manner. (jcancer.org)
CCK-8, plate colony formation and EdU assays were performed to assess the cell proliferation. (biomedcentral.com)

In addition, overexpression of ZYX in hepatoma cell lines (PLC/PRF/5, HCCLM3) enhanced their proliferation, migration and invasion, whereas ZYX knockdown had the opposite effects (SK HEP-1, Huh-7). (techscience.com)
Accumulating evidence suggests that RhoA overexpression contributes to human cancer development. (nih.gov)
Human gastric cancer cell lines AGS and MKN28 were cultured and transfected with miR-149 overexpression plasmid and its control or FOXC1 siRNA and its control. (hindawi.com)
For instance, overexpression of cyclins or the elimination of CDK inhibitors or pRB due to genetic mutation are common cause in human cancer. (ukessays.com)
In vitro and in vivo experiments showed that SNHG4 overexpression markedly enhanced cell resistance to enzalutamide. (biomedcentral.com)
77 IL-8 acts through chemokine receptors 1 and 2 (CXCR1 and 2) and is involved in promoting angiogenesis through overexpression of vascular endothelial growth factor (VEGF) and fibroblast growth factor (FGF). (oncologynurseadvisor.com)

Moreover, we dissected the signaling pathway from the cell surface receptors to RhoA using a broad-spectrum G protein coupled receptor (GPCR) antagonist, [D-Arg1,D-Trp5,7,9,Leu11]Substance P (SP), and a recently reported Galphaq/11-selective inhibitor, YM-254890. (nih.gov)
Finally, the LDHA inhibitor FX11 reduced tumor growth and improved antitumor immunity in CAF-rich PDAC tumors. (jci.org)
Mouse model for mutant allele of the cell cycling inhibitor BARA in mice. (univation.co)
Forced expression of NBPF1 in HEK293T cells resulted in a G1 cell cycle arrest that was accompanied by upregulation of the cyclin-dependent kinase inhibitor p21 CIP1/WAF1 in a p53-dependent manner. (biomedcentral.com)
To investigate the function of TGF- and IL-6 in myofibroblasts (MFs) lung cancers cell connections, lung cancers cells (Lewis and CTM-167 cell lines) were stimulated simply by IL-6, MF-conditioned moderate (MF-CM) or MFs, with or without TGF- signaling inhibitor SB431542 and/or JAK2/STAT3 inhibitor JSI-124. (phytid.org)
BCRC-3 functions as a tumor inhibitor to suppress BC cell proliferation through miR-182-5p/p27 axis, which would be a novel target for BC therapy. (biomedcentral.com)
Treatment with the novel cyclophilin inhibitor NV651, presented a potent antiproliferative effect in HCC cell lines via cell cycle perturbations arresting cells in the mitotic phase. (lu.se)

Tumor suppressors are involved in regulating the cell cycle, ensuring that cells only divide when necessary and that the process is tightly controlled. (pharmiweb.com)
These are divided into two group, those miRNAs that are upregulated in cancer which are likely to be acting as oncogenes and those downregulated in cancer which are likely to be acting as tumour suppressors. (ukessays.com)
regulates EMT or the process by which breast epithelial cells transform into mesenchymal stem cells, which are more motile and invasive and regulates miRNAs, which can act as either tumor suppressors or oncogenes that can transform a normal cell into a tumor cell. (girlsfeel.com)

With the increased understanding of molecular mechanisms and basic pathways in the pathogenesis of squamous cell cancer of the head and neck , these pathways may be modified, and rational approaches in cancer therapy at the molecular level may be created. (medscape.com)
In this study, we investigated how TSPAN12 regulates OC cell proliferation both in vitro and in vivo and found that it contributed to tumor proliferation and poor prognosis in this disease through cyclin and cyclin-dependent kinase (CDK) pathways. (molcells.org)
Here, we review the role of ferroptosis in p53-mediated tumor suppression, with a focus on what cellular factors are critical for p53-dependent ferroptosis during tumor suppression and how p53 modulates both the canonical (GPX4-dependent) and the non-canonical (GPX4-independent) ferroptosis pathways. (nature.com)
Once activated, p53 coordinates multiple downstream pathways, thereby maintaining the homeostasis of the host cell or organism (if the stress is mild, transient, and repairable) or eliminating damaged cells (if the stress is acute, prolonged, and difficult to resist). (nature.com)
High abundance of glucose in the cytoplasm of a cancer cell also increases flux into other metabolic pathways such as hexosamine biosynthetic pathway (HBP) [ 7 ]. (degruyter.com)
However, in recent years, there has been increasing evidence that metformin exerts its anticancer effects through the inhibition of oxidative phosphorylation (OXPHOS) of tumor cell mitochondria, and metabolic pathways based on metformin targeting have only recently become the focus of intensive research. (spandidos-publications.com)
Numerous E3 ubiquitin ligases, which facilitate the ubiquitination of specific substrates, have been shown to control G1/S. In this chapter, we will discuss components in the ubiquitin proteasome system that are implicated in G1/S control, how these enzymes are interconnected, gaps in our current knowledge, and the potential role of these pathways in the cancer cycle and disease proliferation. (intechopen.com)
Several pathways involved in cell cycle and DNA repair were affected upon NV651 treatment. (lu.se)
A number of direct and indirect radiation interaction pathways can produce damage to the DNA of irradiated cells. (cdc.gov)

Expression of the bco2 gene is dramatically decreased in prostate cancer tissue and in a range of prostate cancer cell lines as compared with nonneoplastic prostate tissue and normal prostatic epithelial cells, respectively. (nih.gov)
The human gastric epithelial permanent cell line (GES-1), human gastric cancer cell lines (AGS, BGC-823, MKN45, and SGC-7901), and HEK293 cells were provided by the Biomedical Experiment Center of Xi'an Jiaotong University. (hindawi.com)
Rat AT6-1 prostate tumor cells were characterized in vitro at the transcriptional (bone and epithelial markers) and functional (induction of mineralized nodules) levels. (whiterose.ac.uk)
Apart from epithelial markers, AT6-1 cells express an osteoblast phenotype as they express osteoblastic markers and are able to induce mineralized nodule formation in vitro. (whiterose.ac.uk)

Its biological function, however, especially in ovarian cancer (OC), has not been well elucidated. (molcells.org)
Epidemiologic evidence indicates that lower circulating vitamin D levels are associated with a higher risk of ovarian cancer and that vitamin D supplementation is associated with decreased cancer mortality. (mdpi.com)
We conducted a systematic review of the literature on the effects of vitamin D on ovarian cancer cell. (mdpi.com)
Reishi suppresses the proliferation of ovarian cell cells. (greenmedinfo.com)
Suppression of proliferation and oxidative stress by extracts of Ganoderma lucidum in the ovarian cancer cell line OVCAR-3. (greenmedinfo.com)
In this study, we investigated whether Ganoderma lucidum elicits its anti-tumor effects by suppressing cell growth and inducing antioxidative/detoxification activity in human ovarian OVCAR-3 cells. (greenmedinfo.com)
Celecoxib inhibited cell proliferation in three ovarian cancer cell lines and five primary cultures of human ovarian cancer after 72 hours of exposure. (houstonmethodist.org)
Celecoxib strongly decreased the serum level of VEGF and blood vessel density in the tumors from the KpB ovarian cancer mouse model under obese and non-obese conditions. (houstonmethodist.org)
This work suggests that celecoxib may be a novel chemotherapeutic agent for ovarian cancer prevention and treatment and be potentially beneficial in both obese and non-obese women. (houstonmethodist.org)

L1CAM plays a role in neural development, axon guidance, and cell migration. (pharmiweb.com)
The effects of silibinin on the migration and invasion of oral cancer cells were evaluated using transwell assays. (jcancer.org)
Integrins are key regulators of gene expression, cell proliferation and migration. (europa.eu)

In light of the advancements in tumor biology and molecular technology, further research into the molecular mechanism involved in gastric cancer and identification of biomarkers with high specificity and good targeting [ 3 ] is of great significance for the diagnosis and treatment of this condition. (hindawi.com)
Therefore, identifying biomarkers related to the occurrence, development and prognosis of esophageal cancer is important for early diagnosis and treatment, as well as for finding new targets and treatment methods. (spandidos-publications.com)

Gastric cancer is a highly recurrent malignancy. (hindawi.com)
Previous studies demonstrated that p53 was highly expressed in esophageal cancer tissue and was associated with tumor malignancy ( 15 - 17 ). (spandidos-publications.com)
Oral cancer is a common malignancy of the head and neck region [ 1 ], with more than 350,000 new cases and 177,000 deaths annually recorded worldwide [ 2 ]. (jcancer.org)
The most frequent type of brain tumor is Glioma from grade I to grade IV according to the rate of malignancy. (frontiersin.org)
Notably, the G1/S boundary represents a major barrier to cell proliferation and is universally dysfunctional in cancer cells, allowing for the unbridled proliferation observed in malignancy. (intechopen.com)
Cancer of the uterine corpus is the most common pelvic gynecologic malignancy in the United States and in most developed countries with access to sufficient health care. (medscape.com)

The goal of specific molecular targets in cancer therapy is to create a "magic bullet" that selectively kills cancer cells. (medscape.com)
As our understanding of the molecular biology of HNSCC continues to develop, we can target the specific components of cancer cells that are not found in normal cells. (medscape.com)
Targeted molecular therapy, like therapy with monoclonal antibodies, gene therapy, and other therapies, has limited or nonexistent side effects on normal cells of the body, unlike present modalities such as surgery, chemotherapy, and radiotherapy. (medscape.com)
Targeted molecular therapy can also act as a complement to other existing cancer therapies. (medscape.com)
With increasing globalization and advancements in modern medicine, novel therapeutic approaches such as targeted molecular therapy [ 4 ], immunotherapy [ 5 ], and latent/residual tumor cell ablation have been used to improve clinical outcomes for cancer patients, but the prognosis for patients with gastric cancer remains poor. (hindawi.com)
Recently, the molecular mechanism of miRNAs in tumors has been a popular research topic in tumor-related fields. (hindawi.com)
We aimed to examine the molecular processes underlying the effects of silibinin in oral cancer in vitro and in vivo as well as its potential anticancer effects. (jcancer.org)
Next, we investigated the molecular processes underlying both in vitro and in vivo outcomes of silibinin treatment on oral cancer. (jcancer.org)
With these data it is not yet possible to speak of a cure or safe prevention of colorectal cancer thanks to strawberry tree honey," emphasizes Battino, who adds: "This work constitutes a starting point in the effort to evaluate its possible biological and anti-cancer effects and indicates the main molecular mechanisms through which it exerts its effect, reinforcing the interest in the study and production of this Mediterranean foodstuff. (agenciasinc.es)
These results may provide a molecular explanation for the role of caveolin-1 as tumour suppressor and provide insight into the mechanism of anchorage-independent growth, one of the hallmarks of cancer. (europa.eu)
Therefore, to improve treatment efficacy, it is necessary to tailor therapies to patient and tumor characteristics, using appropriate molecular targets. (frontiersin.org)
In this review we deal in the molecular mechanisms, the epigenetic effects and modulation of the oxidative stress pathway of ketogenic diets, that underlie its possible role, in the treatment of infantile gliomas, as a complementary approach to conventional cancer therapy. (frontiersin.org)
CTNNB1 45F mutation is a molecular prognosticator of increased postoperative primary desmoid tumor recurrence: An independent, multicenter validation study. (medscape.com)

The expression of lactate dehydrogenase A (LDHA), which regulates lactate production, was a poor prognostic factor for patients with PDAC, and LDHA depletion suppressed tumor growth in a CAF-rich murine PDAC model. (jci.org)
It has been proposed that C. elegans LIN-9 functions downstream of CDK4 in a pathway that regulates cell proliferation. (univation.co)
Caveolin-1 regulates anchorage-dependent growth and is a tumour suppressor. (europa.eu)

1) For example, the down-regulation of miR15s and miR - 16 - 1 in chronic lymphocytic leukaemia, prostate cancer and pituitary tumours, leading to the inhibition of tumour growth and induce cell cycle arrest at the G 1 - phase by target cell cycle regulators ( cyclin D1, cyclin E1, cyclin D3 and CDK6). (ukessays.com)
ZOL prevents the development of such osteoblastic lesions, related to a direct inhibitory effect on tumor cell proliferation independent of caspase 3 activation, but associated with cell cycle arrest. (whiterose.ac.uk)
Additionally, forced expression of NBPF1 in two p53-mutant neuroblastoma cell lines also resulted in a G1 cell cycle arrest and CDKN1A upregulation. (biomedcentral.com)
In addition, SNHG4 or RRM2 knockdown significantly induced cell cycle arrest and cell senescence, and inhibited DNA damage repair and cell proliferation, and the effects can be partially reversed by let-7a knockdown or RRM2 reoverexpression. (biomedcentral.com)
Further, blockage of nuclear export of p27 by inhibition of Exportin-1 (XPO1) marketed growth arrest, demonstrating the fact that biological ramifications of agencies relied in the localization and expression of p27. (biotech-angels.com)

However, little is known about how such glucose competition alters metabolism and confers phenotypic changes in stromal cells in the TME. (jci.org)
The foamy stromal cells between the capillaries stain positive for glial fibrillary acid protein and neuron-specific enolase. (medscape.com)

In contrast, there were no significant associations of disease duration, anti-tumour necrosis factor alpha antibodies, or other clinical factors with mCAs. (bvsalud.org)

Ferroptosis acts as an independent pathway for suppressing tumor growth and is tightly connected with metabolism and oxidative stress responses. (nature.com)
Western blotting revealed that silibinin downregulated SOD1 and SOD2 and triggered the JNK/c-Jun pathway in oral cancer cells. (jcancer.org)
Previous studies have demonstrated that glycolysis inhibitors reduce the proliferation of non‑small cell lung cancer (NSCLC) cells by interfering with the aerobic glycolytic pathway. (spandidos-publications.com)
However, the mitochondrial oxidative phosphorylation (OXPHOS) pathway in tumor cells has also been implicated in lung cancer metabolism. (spandidos-publications.com)
In the 1920s, Otto Heinrich Warburg discovered that cancer cells, unlike normal cells, use the glycolytic pathway to obtain energy for growth even in the presence of oxygen, which is a phenomenon known as 'aerobic glycolysis' or the Warburg effect ( 9 ), and aerobic glycolysis is a common metabolic phenotype in NSCLC ( 11 ). (spandidos-publications.com)
It has been reported that lung cancer cells exhibit upregulated expression of all key glycolytic enzymes [hexokinase 2 (HK2), phosphofructokinase and pyruvate kinase (PK)] ( 13 ), suggesting that the essential enzymes of the aerobic glycolytic pathway have a critical role in the development of lung carcinoma. (spandidos-publications.com)
We could confirm the increased polyploidy upon Mps1 inhibition in neuroblastoma cell lines and PDX model, leading to mitotic catastrophe activating the caspase-dependent mitochondrial apoptotic pathway. (lu.se)
tax causes malignant transformation not through integration and insertional mutagenesis, as many retroviruses do, but by inhibition of DNA repair (base excision pathway) and trans-activating disruption of cellular growth control mechanisms ( 2 ). (cdc.gov)

As proof-of-concept, we show that in vivo knockdown of ASncmtRNAs results in drastic inhibition of tumor growth in a xenograft model of MDA-MB-231 subcutaneous tumors, further supporting this approach for the development of new therapeutic strategies against breast cancer. (uandes.cl)
Therefore we investigated the antitumor effects of DMC on a HeLa cell xenograft model in nude mice in this study. (iiarjournals.org)
Results: DMC significantly reduced tumor weights and volumes of HeLa cell xenografts in mice, indicating the suppression of growth of xenograft tumors. (iiarjournals.org)
Silibinin significantly inhibited xenograft tumor growth in nude mice, with no obvious toxicity. (jcancer.org)
Importantly, silibinin effectively suppressed xenograft tumor growth in nude mice. (jcancer.org)
In addition, NV651 decreased tumour growth in xenograft-mouse model. (lu.se)

This study provides new insights into RhoA signaling in lung cancer cells and may help in developing novel therapeutic strategies against lung cancer. (nih.gov)
This indicates the intricate control of metabolism and redox balance for survival of cancer cells that can be targeted by therapeutic agents. (degruyter.com)
A review on therapeutic targeting of cancer via death receptors dissects this topic comprehensively and is therefore subtly discussed in this minireview which focuses on ROS cancer therapeutics [ 22 ]. (degruyter.com)
Silibinin has been reported to exert therapeutic effects in various cancer models. (jcancer.org)
Therapeutic approaches that target the metabolism of tumor cells have been a popular research topic in recent years. (spandidos-publications.com)
Our study provides insight regarding the crosstalk among tumor cells, CAFs, and immune cells mediated by lactate and offers therapeutic strategies for targeting LDHA enzymatic activity in PDAC cells. (jci.org)
The paper reported on the therapeutic potential of ginsenosides , the herb's main bioactive component, and their prospects in the treatment of fatal diseases such as cancer. (girlsfeel.com)
Relevant studies concluded that acquired chemoresistance can be reversed or suppressed by ginseng's ginsenosides and improves sensitivity to drugs in patients undergoing chemotherapy - confirming that ginsenosides taken with other pharmaceutical agents in new therapeutic strategies for cancer or may be used alone - with little to no adverse event or negative side effects. (girlsfeel.com)
Targeting the cell cycle has been proposed as a therapeutic strategy in cancer treatment with special interest in the mitotic phase. (lu.se)
Despite methodological differences, findings evidence that although IBC presents particular features (lower survival rate and worse prognostics than most types of breast cancer), very few studies examine its epidemiology and specific risk factors in depth and use any other therapeutic approaches than those commonly used for other breast cancer subtypes. (bvsalud.org)

The aim of this study was to investigate the in vitro antitumor effects of Nidus Vespae on gastric cancer and its ability to promote immune function. (hindawi.com)
Background/Aim: Demethoxycurcumin (DMC), a derivate of curcumin from natural plants, exerts antitumor effects on various human cancer cells in vitro and in vivo. (iiarjournals.org)
In a study published in Food & Function , in in vivo and in vitro lung cancer models, ginsenosides Rg3, Rh2, and CK were reported to have strong anti-lung cancer effects . (girlsfeel.com)
Laboratory studies have shown that Ganoderma lucidum enhances immune functions and also inhibits growth of various cancer cells both in vitro and in vivo. (greenmedinfo.com)
The effects of BCRC-3 on cancer cells were explored by transfecting with plasmids in vitro and in vivo. (biomedcentral.com)
Proliferation of BC cells was suppressed by ectopic expression of BCRC-3 in vitro and in vivo. (biomedcentral.com)
NV556 treatment in an in vitro 3D human liver Extracellular Matrix (ECM) cultured with a TGFβ1-activated human hepatic stellate cell line led to decreased collagen production. (lu.se)
In vitro studies based on MCF-7 cell proliferation and induction of vitellogenin in primary culture of rainbow trout hepatocytes. (cdc.gov)

Cyclin A2, Cyclin D1, Cyclin E2, CDK2, and CDK4) were significantly involved in the regulation of cell cycle downstream of TSPAN12. (molcells.org)
Therefore, investigating the expression and regulation of miRNAs may elucidate the mechanism of gastric cancer. (hindawi.com)
1) The regulation of these protein levels is vital for the understanding of the cell cycle control and its dysregulation. (ukessays.com)
Apoptotic death is preceded by proliferation blockage, suggesting that these transcripts are involved in cell cycle regulation. (uandes.cl)
This gene thus plays a role in both cell-cycle and epigenetic regulation. (cancerindex.org)
equally central to the regulation of cell signaling. (scienza-under-18.org)

The aim of the present study was to investigate the association between tumor protein 53 (TP53) gene deletion and protein expression and clinical features in esophageal squamous cell carcinoma (ESCC), and to evaluate the predictive value of these two characteristics in the prognosis of ESCC. (spandidos-publications.com)
However, other previous studies reported that the expression of p53 protein had no significant association with the prognosis of esophageal cancer ( 18 , 19 ). (spandidos-publications.com)
However, it has a favorable prognosis because the majority of patients present at an early stage, resulting in only 4% of cancer deaths in women. (medscape.com)
9% of cancers of uterine corpus, however is associated with more aggressive behavior and a poorer prognosis. (medscape.com)

Various techniques have been developed for targeting cancer cells: gene therapy, monoclonal antibodies (MAbs), antibody toxin conjugates, small-molecule inhibitors, antisense molecules, and tumor vaccines. (medscape.com)
Poly(ADP-ribose) polymerase (PARP) inhibitors have been recently approved for BRCA1/2-mutant pancreatic cancer, opening a new era for targeted therapy for this disease. (techscience.com)
However, most pancreatic cancer patients carry wild-type BRCA1/2 with resistance to PARP inhibitors. (techscience.com)
Accordingly, cells treated with MG132 or other proteasome inhibitors exhibit higher expression of MKP3/DUSP6, an ERK1/2-specific DUSP, accompanied by lower levels of ERK phosphorylation stimulated by growth factors [12]C[14]. (scienza-under-18.org)
particular inhibitors inhibited cell proliferation and tumor growth of lung tumor cells significantly. (phytid.org)

As the cancer volume increases, the cancer may release angiogenesis factors, such as vascular endothelial growth factor (VEGF), which promote formation of new blood vessels that are required for further growth. (msdmanuals.com)

3) p53 null mice develop tumors with 100% penetrance. (nature.com)
most individuals with genetic changes associated with this condition never develop tumors. (medlineplus.gov)
People with DICER1 syndrome who develop tumors most commonly develop pleuropulmonary blastoma, which is characterized by tumors that grow in lung tissue or in the outer covering of the lungs (the pleura). (medlineplus.gov)

p53-mediated ferroptosis is required for its tumor suppression in mouse models. (nature.com)
What is the physiological ferroptosis inducer(s) for p53 during tumor suppression? (nature.com)
BARAΔ84/Δ84, the shortened version of BARA with the first 84 amino acids eliminated from the coding sequence of the gene, can be used in research of the cell cycle, growth hormone production, as well as cancer associated with pRB suppression. (univation.co)

The incidence rate of gastric cancer is fifth in the world, and the mortality rate is third, second only to lung cancer and colorectal cancer [ 1 ]. (hindawi.com)
The first solid tumor exomes to be investigated were from 11 breast and 11 colorectal cancer tissue samples. (frontiersin.org)
Experimentations with wild-type probiotics have been performed against not only colorectal cancer , but also other cancers such as bladder, breast, cervical, and liver cancers. (metabiom.org)
It is the fourth most common cancer, accounting for 7% of female cancers, following breast, lung, and colorectal cancer. (medscape.com)
Another group of women at increased risk of premenopausal endometrial cancer are those with Lynch II syndrome, also known as hereditary nonpolyposis colorectal cancer (HNPCC). (medscape.com)

The authors hope that these promising results and the anti-tumour potential of this food will be confirmed in in vivo models. (agenciasinc.es)
The cytotoxicity and anti-tumour effects of strawberry tree honey in relation to colon cancer lines increased with the amount and time of treatment. (agenciasinc.es)

The initiation and development of tumor cell is accompanied by elevated stresses, such as oncogene activation, DNA damage, genome instability, and reprogrammed tumor metabolism. (nature.com)
Given the vast differences in metabolism between healthy and tumor cells, there is hope that selective targeting of tumor metabolism may be achieved while limiting toxicity to healthy tissue. (spandidos-publications.com)
The most striking and characteristic metabolic alteration in cancer cells is anomalous glucose metabolism and cancer cells tend to utilize glycolysis to obtain energy even under aerobic conditions via a process called 'aerobic glycolysis' ( 9 ). (spandidos-publications.com)

However, with the development of immunology, western scientists are gradually realizing the importance of homeostasis in the human body, especially immune balance in tumor patients [ 9 ]. (hindawi.com)
however, the treatment of patients with cervical cancer depends on the cancer stage and tumor location according to diagnosis and characteristics of the patients ( 7 , 8 ). (iiarjournals.org)
Other side-effects of the current chemotherapy treatment of patients with cervical cancer are fatigue, nausea, vomiting, and diarrhea ( 11 ). (iiarjournals.org)
CDK2AP1 expression in disease-free patients at 10 years was more than threefold that of patients who died of breast cancer. (cancerindex.org)
Although treatment for oral cancer has improved over the years, the disease still proves fatal to a large number of patients. (jcancer.org)
Many promising cancer drugs being developed will require years to become approved by regulatory bodies and, in most cases, will only be effective for a fraction of patients with specific types of cancer. (kingdomfasting.com)
However, DR is not feasible for patients already prone to weight loss from the cancer itself or from the chemotherapy, because, based on animal studies, several months may be necessary for patients undergoing DR to reach a protected state. (kingdomfasting.com)
By contrast, a limited exposure to a severely restricted diet (short-term starvation or fasting) can protect yeast, mammalian cells, mice, and possibly patients from the toxic effects of oxidative and chemotherapeutic agents without causing chronic weight loss (10-14). (kingdomfasting.com)
Though challenges remain, clinicians are in the early stages of using genetic data to make treatment decisions for cancer patients. (frontiersin.org)
Clinical trials to date have benefited only limited subsets of patients, accentuating the fact that pediatric high-grade gliomas (HGGs) constitute an extremely heterogeneous group of highly aggressive brain tumors. (frontiersin.org)
The use of alternative and adjuvant therapies in pediatric cancer patients appears to be a frequent choice as reported in the reviewed literature. (frontiersin.org)
We found that RRM2 and NUSAP1 are highly expressed in PCa tumors and significantly correlated with poor clinical outcomes in PCa patients. (biomedcentral.com)
However, most PCa patients inevitably develop castration-resistant prostate cancer (CRPC), which is a fatal form of PCa that is difficult to confront [ 6 ]. (biomedcentral.com)
Lingzhi (LZ) is a medical mushroom also known as Ganoderma lucidum, which has been used in traditional Chinese medicine for more than 4,000 years and moreover, due to its presumed health benefits and apparent absence of side-effects it has also been widely consumed as a dietary supplement by cancer patients and by individuals diagnosed with various chronic diseases. (greenmedinfo.com)
Within the range of practical loss connected with lung tumor are breathing disorders such as chronic pulmonary obstructive disease, emphysema, and asthma, which further reduces the quality of life for patients. (phytid.org)
Mortality of intra-abdominal desmoid tumors in patients with familial adenomatous polyposis: a single center review of 154 patients. (medscape.com)
2014). genetic StudieS are carried out, uSing tuMour SaMPleS froM PatientS with excellent clinical data that have been collected at a PoPulation level or internationally, to Provide unique data coMbining the Pathology, geneticS, clinical featureS, and ePideMiology of tuMourS. (who.int)
[ 2 ] Diagnosed in 50% of patients with VHL disease, these hemangiomas are composed of endothelial cells and pericytes. (medscape.com)
Tumors involving other organs and the CNS (brain, spinal cord) are present in 25% of patients with VHL disease. (medscape.com)
Clinicians can play a role in skin cancer prevention by counseling their patients on use of sun protection and indoor tanning avoidance. (cdc.gov)
Circulating cancer cells are present in many patients with advanced cancer and even in some with localized disease. (msdmanuals.com)
Most patients with cancer die from metastases rather than the primary cancer. (msdmanuals.com)
Concerns that this virus might infect humans through exposure to food products from subclinically infected animals prompted 10 studies that used what were then (1975-1979) state-of-the-art immunologic methods to test serum samples from a collective total of 1,761 humans, including cancer patients, farm workers, and veterinarians ( 5 ). (cdc.gov)

It is estimated that 1 in 3 domestic dogs will develop cancer, which is the same incidence of cancer among humans. (wikipedia.org)
China has a high incidence of esophageal cancer and the highest morbidity and mortality rates in the world. (spandidos-publications.com)
The incidence of esophageal cancer exhibits significant regional and ethnic differences ( 6 ). (spandidos-publications.com)
The incidence of cervical cancer is increasing worldwide. (iiarjournals.org)
Tobacco and alcohol use increase the development and incidence rates of oral cancer as the main risk factors. (jcancer.org)
According to the latest statistical report from the American Cancer Center from 2021, lung cancer has the second-highest incidence and the highest mortality rate among all malignancies ( 2 ). (spandidos-publications.com)
1] The incidence of NMSC, which has increased over the past 20 years in the United States, may be related to higher levels of outdoor activities and sun exposure, changes in clothing style, and improved skin cancer detection. (jcadonline.com)
The incidence of brain tumors in children is about 5 cases per 100,000 population, 75% of which are classified as gliomas ( 2 ). (frontiersin.org)
Prostate cancer threatens the health of men over sixty years old, and its incidence ranks first among all urinary tumors among men. (biomedcentral.com)
After doubling in the early 1970s, the incidence of uterine cancer has remained fairly constant. (medscape.com)
Breast cancer is a public health problem, its incidence increases worldwide. (bvsalud.org)

In this study, we examined both the expression levels and the activation states of RhoA in various lung cancer cells by quantitative real-time reverse transcriptase-polymerase chain reaction and in vivo Rho guanine nucleotide exchange assay, respectively. (nih.gov)
We found that four of six small cell lung carcinoma (SCLC) cell lines exhibited a moderate to high activation rate of RhoA. (nih.gov)
Our results suggest that RhoA is activated in various lung cancer cells independent of its expression levels, and the high activation state of RhoA in SCLC cells mainly depends on a neuroendocrine peptide autocrine system which signals through Galpha12 coupled GPCR to RhoA. (nih.gov)
Lung cancer is the most common cause of cancer-related death worldwide ( 1 ). (spandidos-publications.com)
There are primarily two types of lung cancer: Non-small cell lung cancer (NSCLC) and SCLC, and the former accounts for ~85% of all lung cancer cases ( 3 ). (spandidos-publications.com)
The study suggested ginsenosides as a potential natural medicine to protect the lungs from lung cancer and inflammatory lung disease. (girlsfeel.com)
Our research demontrated that the TGF- and IL-6/JAK2/STAT3 signaling paths type a positive responses signaling cycle that mediated the relationships between MFs and lung tumor cells. (phytid.org)
Targeted inhibiton of this signaling cycle could end up being a fresh strategy for lung tumor therapy and prevention. (phytid.org)
Intro Lung tumor can be a major trigger of cancer-associated fatality and morbidity, with over 1 million fatalities from the disease world-wide per yr1. (phytid.org)
A commonality between these associated functional pathologies is a connective tissue dysregulation at least in part mediated by inflammatory events that occur within the lung tissue and tumor stroma2. (phytid.org)
Signaling paths controlled by TGF- in lung tumor cells consist of Wnt/-catenin, MAPK, and JAK/STAT3 signaling11. (phytid.org)
Latest research reveal that individuals with diagnosed lung tumor possess raised serum IL-6 (likened with regular topics) and it can be related with poor diagnosis12, 13. (phytid.org)
Outcomes Lung tumor cell-produced TGF- induce MF expansion and cytokine release To measure MF expansion, we cultured the cells with different remedies, and CCK-8 was assayed at 0?l, 24?l and 48?l. (phytid.org)
Emerging evidence suggests that sedentary behaviour is associated with an increased risk of cancers of the breast, colon, endometrium, and lung. (who.int)
Air pollution alone was responsible for an estimated 350 167 deaths from lung cancer worldwide in 2017. (who.int)

BARA inhibits cell proliferation via collaboration with tumor suppressor Retinoblactoma protein (pRB). (univation.co)

Selective breeding of dogs has led certain pure-bred breeds to be at high-risk for specific kinds of cancer. (wikipedia.org)
The selective breeding techniques used with domestic dogs causes certain breeds to be at high risk for specific cancers. (wikipedia.org)

The THP-1 human monocytic cell line was used as a source of monocytic effector cells for analyzing proliferation and dendritic cell (DC) induction. (hindawi.com)
An infectious etiology for a number of cancers has been entertained for over 100 years and modern studies have confirmed that a number of viruses are linked to cancer induction. (surgicalneurologyint.com)

Redirection of glutamine to cellular energetics destabilizes glutathione homeostasis in glioblastoma cells and other cancer cells [ 9 ]. (degruyter.com)
However, the roles of circRNAs in cellular proliferation in bladder cancer remain largely unknown. (biomedcentral.com)
destroy tumors by secreting exotoxins that damage the membrane structures of cancer cells and enter cells to disrupt essential cellular functions. (metabiom.org)
A very large radiation dose received in a short enough period of time to preclude significant repair can cause cellular walls to collapse and disrupt organ systems, producing deterministic effects such as acute radiation syndrome, cataracts, and teratogenesis (mental retardation, IQ reduction, microencephaly, stunted growth). (cdc.gov)
The cellular kinetics of particular cancers is an important consideration in the design of antineoplastic drug regimens and may influence the dosing schedules and timing intervals of treatment. (msdmanuals.com)

This study evaluates the effect of A. montana leaves hexane extract on several signaling cascades and gene expression in metastatic breast cancer cells upon insulin-like growth factor-1 (IGF-1) stimulation. (techscience.com)
Lymphendothelial gaps, adjacent to tumour bulks, can be considered as gates facilitating metastatic spread. (nature.com)
The results, published in the Journal of Functional Foods, show that strawberry tree honey is capable of inhibiting the proliferation of tumour cells cultivated in laboratory plates - more specifically, those of a line of human colon adenocarcinoma (HCT-116) and another with metastatic characteristics (LoVo), widely used to investigate this type of tumour. (agenciasinc.es)
Strawberry tree honey is capable of inhibiting the proliferation of tumour cells on a line of human colon adenocarcinoma (HCT-116) and another with metastatic characteristics (LoVo). (agenciasinc.es)
4,6,10] Squamous tumors have a metastatic risk of 0.5 to 3.3 percent. (jcadonline.com)
Metastatic castration-resistant prostate cancer (mCRPC) is a type of cancer that is resistant to conventional prostate cancer treatments, such as androgen deprivation therapies (ADTs) and other chemotherapies. (oncologynurseadvisor.com)

Cancer stem cells have been found to be particularly susceptible to infection by human cytomegaloviruses. (surgicalneurologyint.com)
A subpopulation of cells within a cancer has the properties of stem cells. (msdmanuals.com)

Cells are potent to go under abnormal growth processes and finally lead to tumor/cancer. (pharmiweb.com)

Here, we show that ASncmtRNA knockdown induces cell death preceded by proliferative blockage in three different human breast cancer cell lines. (uandes.cl)
The treatment also induces an increase in the microRNA hsa-miR-4485-3p, whose sequence maps to ASncmtRNA-2 and transfection of MDA-MB-231 cells with a mimic of this miRNA induces cyclin B1 and D1 downregulation. (uandes.cl)

Tumor protein 53 ( TP53 ) is a recognized tumor suppressor gene located on chromosome 17q13.1. (spandidos-publications.com)

Most cancer cells undergo metabolic reprogramming that support their survival and proliferation. (degruyter.com)

Aggressive fibromatosis (desmoid tumor) is derived from mesenchymal progenitor cells. (medscape.com)

Oncogenes responsible for cell growth are overexpressed in cancerous cells. (wikipedia.org)

The aim of this study was to investigate the function of miRNA-149 and FOXC1 in gastric cancer. (hindawi.com)
miRNA-149 inhibits the biological behavior of gastric cancer by targeting FOXC1, providing a promising target in the treatment of human gastric cancer. (hindawi.com)
Several studies have confirmed that miRNA can be used as an oncogene or tumor suppressor gene to regulate the occurrence and development of gastric cancer [ 6 ]. (hindawi.com)
The understanding of miRNA has increased over the past 10 years, and particularly the involvement of miRNAs in cancer. (ukessays.com)
A greater understanding of miRNA could possibly lead to better diagnostic and treatment of cancer. (ukessays.com)

Our findings suggest that NVD not only directly inhibits the growth of gastric cancer cells but also exerts indirect antitumor effects by enhancing immune function. (hindawi.com)
These results provide an important theoretical basis for the clinical application of Nidus Vespae in gastric cancer treatment. (hindawi.com)
Globally, gastric cancer remains a serious threat to human health given its high morbidity and mortality [ 1 - 3 ], and tumor treatment continues to be an important issue in modern medicine. (hindawi.com)
Gastric cancer is one of the most common cancers in the world. (hindawi.com)
The detection rate of early gastric cancer is low and lacks specificity. (hindawi.com)
In this study, we investigated the inhibitory effects of miR-149 on the biological functions of gastric cancer cells by targeting FOXC1. (hindawi.com)

This study investigated expression and functional roles of BCO2 in human prostate cancer. (nih.gov)
Many canine cancers are described with the same terminology and use the same classification systems as human cancers. (wikipedia.org)
With its absence, the human body will be functioning without its "brake" of cell proliferation. (pharmiweb.com)
We also discuss the possibility of targeting p53-mediated ferroptotic responses for the treatment of human cancers and potentially, other diseases. (nature.com)
Nevertheless, no reports have disclosed whether DMC can affect the growth of human cervical cancer cells in vivo. (iiarjournals.org)
The experimental design for the demethoxycurcumin (DMC) treatments in human cervical HeLa cell-bearing mice. (iiarjournals.org)
To our knowledge, this is the first study in the literature to examine the mRNA expression of CDK2AP1 in human breast cancer over a long-term follow-up period. (cancerindex.org)
Experiments in simple organisms, human cells, and mice indicated that these effects of fasting were caused by changes inside and outside cells that increased the death of tumor but not normal cells, a process termed differential stress sensitization. (kingdomfasting.com)
The first cancer exomes were sequenced soon after the completion of the Human Genome Project in 2001. (frontiersin.org)
Cell Culture and Immunoblotting NIH 3T3 mouse fibroblast and HT-1080 human fibrosarcoma cell lines were acquired from American Type Culture Collection (Manassas, VA). Mouse embryonic fibroblasts, derived from pregnant CD-1 mice (Charles River Laboratories, Wilmington, MA), were. (scienza-under-18.org)
The human body has nearly 1013 cells. (cdc.gov)
When the new guidelines assessing potential human cancer risk posed by envi- are final, EPA will make them available on the world ronmental agents, the concept of low-dose linearity wide Internet via its homepage ZHTTP:rrwww. (cdc.gov)
Air pollution, both outdoor and indoor, is the most widely investigated and most important contributor to the environmental cancer burden in human populations. (who.int)
Cervical cancer may be eliminated as a public health problem by vaccination against human papillomavirus (HPV) infection, even in low-income countries where cervical cancer is the major cancer type. (who.int)

Materials and Methods: Twenty-four nude mice were subcutaneously injected with HeLa cells. (iiarjournals.org)
Short-term starvation (or fasting) protects normal cells, mice, and potentially humans from the harmful side effects of a variety of chemotherapy drugs. (kingdomfasting.com)
Furthermore, it was found that BARA/LIN-9 acts downstream of cyclin D/CDK4 in mammalian cells because its antiproliferative effect is partially blocked by coexpression of cyclin D1, and also because the mutant BARA form lacking the first 84 amino acids (BARAΔ84/Δ84) restores fertility, prevents onset of diabetes and reverses low mouse body size associated with mice null for cdk4. (univation.co)
In the KpB mice fed a high fat diet (obese) and treated with celecoxib, tumor weight decreased by 66% when compared with control animals. (houstonmethodist.org)
Among KpB mice fed a low fat diet (non-obese), tumor weight decreased by 46% after treatment with celecoxib. (houstonmethodist.org)
Administration of BH4 to mice markedly reduces tumour growth and expands the population of intratumoral effector T cells. (metabiom.org)
#Bifidobacterium is associated with antitumor effects, and oral administration of #Bifidobacterium alone improved tumor control to the same degree as PD-L1 antibody therapy while combination treatment nearly abolished tumor growth in mice. (metabiom.org)

Anatomy20

Organisms8

Diseases51

Chemicals and Drugs81

Analytical, Diagnostic and Therapeutic Techniques and Equipment44

Phenomena and Processes56

Disciplines and Occupations1

Information Science4

Health Care4

Apoptosis45

Progression31

Differentiation11

Metastasis8

Microenvironment7

Genes20

Tissues14

Mutations11

Proteins14

Solid tumors2

Malignant tumors3

Colony formation7

Overexpression6

Inhibitor7

Suppressors3

Pathways9

Epithelial4

Ovarian9

Migration3

Biomarkers2

Malignancy6

Molecular13

Regulates3

Arrest5

Stromal2

Necrosis factor-alpha1

Pathway8

Xenograft6

Therapeutic10

Vitro8

Regulation6

Prognosis4

Inhibitors5

Angiogenesis1

Develop tumors3

Suppression3

Colorectal cancer5

Anti-tumour2

Metabolism3

Patients23

Incidence11

Lung15

Inhibits cell proliferation1

Selective2

Induction2

Cellular5

Metastatic6

Stem cells2

Lead to tumor1

Induces2

Protein 531

Survival and proliferation1

Mesenchymal1

Oncogenes1

MiRNA5

Gastric cancer6

Human14

Mice7