Cancer tumor cell proliferation and migration tumor cells cell cycle. Medical search. Frequent questions

Flow cytometry was used to examine apoptosis, cell cycle distribution, and accumulation of reactive oxygen species (ROS). (jcancer.org)
Moreover, it induced cell cycle arrest in the G0/G1 phase, apoptosis, and ROS generation in these cells. (jcancer.org)
Silibinin considerably reduced the development of oral cancer cells by inducing apoptosis, G 0 /G 1 arrest, ROS generation, and activation of the JNK/c-Jun pathway. (jcancer.org)
Exhibiting high consistence in sequence and structure, S100 family members are interchangeable in function and they show a wide spectrum of biological processes, including proliferation, apoptosis, migration, inflammation and differentiation and the like. (cancerindex.org)
In contrast, no significant alteration of apoptosis in the BCa cells with downregulated LAPTM5 was noticed. (spandidos-publications.com)
NF-kappaB and AP-1 transcriptional factors contribute to the development and progression of prostate malignancy by regulating the expression of genes involved in proliferation, apoptosis, angiogenesis, and metastasis. (positivehealth.com)
The above studies shows how Vitamin E succinate interacts in different ways with the complex array of genes involved in the development and progression of prostate cancer - genes involved in proliferation, apoptosis, angiogenesia and metastasis. (positivehealth.com)
it inhibits cell migration, reduces the ability to form colonies and induces apoptosis or programmed cell death through the modulation of other key genes (p53, caspase-3, c-PARP) and various apoptotic factors," says Maurizio Battino, coordinator of the research. (agenciasinc.es)
It also suppresses the receptor of the epidermal growth factor called EGFR/HER2 and its signalling pathways, which could be an attractive target in cancer therapies because of their important role in the processes of cell survival and proliferation, as well as in those of apoptosis and metastasis. (agenciasinc.es)
Cell apoptosis and cycle were detected by flow cytometry. (jcancer.org)
we found that EERAC inhibited the cell viability, migration, and invasion of SW480 cells in a concentration dependent manner, but promoted apoptosis and the cell percentage in S phase significantly. (jcancer.org)
Promoting PTEN expression in CRC cell lines will stop the activation of the phosphatidylinositol-3-kinase ( PI3K )/sinkserine/threonine kinase ( Akt ) signaling pathway, which affects CRC cell growth, promotes apoptosis, and improves sensitivity to targeted therapy, immunotherapy, and conventional therapy. (aging-us.com)
IM combined with IR can synergistically inhibit the proliferation, apoptosis, clonogenesis, invasion, migration and cell cycle of GIST cells. (researchsquare.com)
Lastly, the BJBMS stated that the cannabinoids themselves affect the signaling pathways that are responsible for tumor cells survival and went on to state that the cannabinoids can "…induce cell cycle arrest, promote apoptosis (cell death), and inhibit proliferation, migration, and angiogenesis in tumor cells" (Dariš, Tancer, Knez, Ferk, 2019). (beescannafarm.com)
This is the case, for instance, of loss-of-function mutations of TP53 , amplifications of MDM2 and MDM4 , and deletions of CDKN2A , all leading to evading apoptosis and uncontrolled proliferation in malignancies such as glioblastoma. (biomedcentral.com)
Furthermore, silencing PrP c expression with si-PRNP amplified the fucoidan-induced changes in cell proliferation, apoptosis, and migration. (iiarjournals.org)
Crypt hyperplasia in GCC-/- mice was associated with compensatory increases in cell migration and apoptosis. (jefferson.edu)
Indeed, in colons of mice carrying mutations in Apc (ApcMin/+) or exposed to the carcinogen azoxymethane, elimination of GCC increased tumor initiation by corrupting genomic integrity in the context of disabled compensatory apoptosis. (jefferson.edu)
Loss of cell division cycle‑associated 5 promotes cell apoptosis by activating DNA damage response in clear cell renal cell carcinoma. (nih.gov)
Silencing oncogene cell division cycle associated 5 induces apoptosis and G1 phase arrest of non-small cell lung cancer cells via p53-p21 signaling pathway. (nih.gov)
Downregulation of CDCA5 Can Inhibit Cell Proliferation, Migration, and Invasion, and Induce Apoptosis of Prostate Cancer Cells. (nih.gov)
In addition, gain and loss-of-function studies with miR-206 mimics and inhibitors showed that inhibition of miR-206 in hypoxic MSCs promoted the migration ability of the cells, prevented cell apoptosis, and protected membrane potential of mitochondria, while the benefits were all blocked by Pim-1 inhibitor. (biomedcentral.com)
These pro- has been implicated as contributing apoptosis, inflammation, and several liferating cel s replace dead cel s to the cancer phenotype, through pleiotropic responses. (who.int)
Role of PDL-1 in NSCLC chemoresistance was assessed using CRISPR/Cas9 knockdown and various functional assays including MTT, cell invasion, sphere formation, and cell apoptosis. (cdc.gov)
Mechanistically, an upregulation of PDL-1 in chemotherapy-treated CAFs led to an increase in hepatocyte growth factor (HGF) secretion, which stimulates cancer progression, cell invasion, and stemness of lung cancer cells, while inhibiting apoptosis. (cdc.gov)

Low AKAP12 expression in a larger cohort of patients (75) characterized tumor invasiveness, recurrence, and progression, indicating its potential as a prognostic biomarker. (nature.com)
The development of human cancer is a multistep process characterized by the accumulation of genetic and epigenetic alterations that drive or reflect tumour progression. (nih.gov)
A vast amount of research exists on the possible molecular mechanisms through which vitamin D affects cancer cell proliferation, cancer progression, angiogenesis, and inflammation. (mdpi.com)
S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. (cancerindex.org)
Recently, HMGB1 has been recognized as a positive regulator of tumor glutamine, and its overexpression has been correlated with tumorigenesis and cancer progression. (bvsalud.org)
However, functions and mechanisms of HMGB1 in regulation of glycolysis during cancer progression in lung adenocarcinoma (LUAD) is still unclear. (bvsalud.org)
In this research, we aimed to explore the role and mechanism of BCL6 in malignant progression and ferroptosis of gastric cancer. (bvsalud.org)
CONCLUSIONS: In summary, BCL6 should be considered a potential intermediate tumor suppressor to inhibit the malignant progression and induce ferroptosis, which might be a promising molecular biomarker for further mechanistic investigation of GC. (bvsalud.org)
In recent years, epithelial-mesenchymal transition (EMT) has been suggested to play a key role in the process of embryonic development, differentiation of tissues and organs, chronic inflammation and fibrosis, as well as cancer progression ( 14 ). (spandidos-publications.com)
CRISPEN and COLLEAGUES, Fox Chase Cancer Center, Philadelphia, PA 19111, USA studied the interaction with and modulation of Vitamin E succinate upon transcriptional factors involved in the development and progression of prostate cancer. (positivehealth.com)
This specific project aims to identify sequences within caveolin involved in regulation of raft internalisation, cell cycle progression and anchorage-dependent cell growth. (europa.eu)
This objective integrates into a bigger project that also aims to identify molecular mechanisms by which caveolin regulates anchorage-dependent signalling pathways and cell cycle progression and to identify oncogenes that induce constitutive surface localization of rafts (and hence Rac), and/or changes in phosphocaveolin localization. (europa.eu)
proteasome inhibition interferes with cell cycle progression, upregulates tumor suppressors such as p53, and diminishes activation of pro-proliferation pathways such as those controlled by NFB and extracellular signal-regulated kinases (ERKs) [3], [4]. (scienza-under-18.org)
This study is to investigate the expression changes of lymphocyte migration regulation related proteins in urine exosomes of lung cancer patients, and further verify their correlation with the development and progression of lung cancer. (biomedcentral.com)
Genetic mutations participate in development and progression of cancer. (drtaheriazam.com)
It functions as double-edged sword and has ability of suppressing tumor progression. (drtaheriazam.com)
The role of the ncRNA/autophagy axis in affecting the progression of gastric, liver, colorectal, pancreatic, esophageal, and gallbladder cancers is investigated. (drtaheriazam.com)
The current review focuses on the role of miR-21 in cancers and its association with tumor progression. (drtaheriazam.com)
miR-21 primarily decreases PTEN expression to induce PI3K/Akt signaling in cancer progression. (drtaheriazam.com)
Cancer progression results from activation of various signaling networks. (drtaheriazam.com)
The study is designed to investigate the effect and molecular mechanism of KIF18A on the progression of colorectal cancer. (aging-us.com)
PTEN can inhibit cell cycle progression and induce cell death to stimulate angiogenesis [ 6 ]. (aging-us.com)
The siRNA-mediated DEPDC1 depletion resulted in significant inhibition of proliferation and delay in cell cycle progression in both NPC cell lines, CNE-1 and HNE-1. (oncotarget.com)
Taken together, our present study demonstrated that DEPDC1 is essentially required for the accelerated cell cycle progression and motility in NPC cells, and strongly suggested that DEPDC1 may serve as a novel therapeutic target in NPC. (oncotarget.com)
Background: The putative functions of the cellular prion protein (PrP c ) are believed to be associated with cell signaling, differentiation, survival, and cancer progression. (iiarjournals.org)
With respect to cancer development and progression, elevations and mutations of PrP c expression have been shown to increase the risk for malignancy and metastasis in breast and colorectal cancer. (iiarjournals.org)
Since both natural supplements and direct regulation of PrP c expression contribute to inhibition of cancer progression and growth, we hypothesized that knockdown of PrP c could lead to an enhanced synergic effect on the inhibition of cancer growth by fucoidan. (iiarjournals.org)
Recent evidences demonstrate that dysregulated expression of microRNA-320d (miR-320d) has been associated with several cancer development and progression. (biomedcentral.com)
Modulating miR-320d function by transfection of miR-320 mimics or inhibitor led to inhibition or promotion of GCA cell proliferation and invasion, thus regulating tumor progression in GCA-tumor bearing mice. (biomedcentral.com)
CDCA5 promotes the progression of breast cancer and serves as a potential prognostic biomarker. (nih.gov)
CDCA5 promotes the progression of prostate cancer by affecting the ERK signalling pathway. (nih.gov)
MDM2 ISH (mouse double minute 2) MDM2 is a gene that encodes a protein that inhibits p53 activation and promotes progression through the cell cycle. (azbio.org)
Genetic amplifications of MDM2 are associated with aberrant progression through the cell cycle and the formation of neoplasms. (azbio.org)
Additionally, miR-146a silencing or restoration of FLAP led to a reduction of HepG2 cell proliferation, cell cycle progression, migration, and invasion. (biomedcentral.com)
Recent reports have implicated that BEX2 is involved in tumor development and progression in several types of cancer, such as glioblastoma, glioma and breast cancer [ 7 - 9 ]. (ijbs.com)
However, biological roles of lncRNAs in occurrence and progression of colorectal cancer (CRC) remain unclear. (biomedcentral.com)
Therefore, their dysregulation may participate in NPC cell invasion and migration, contributing to its progression and metastasis. (biomedcentral.com)
Cytarabine blocks the progression from G1 to the S phase and, in turn, kills cells that undergo DNA synthesis in the S phase of the cell proliferation cycle. (medscape.com)
PSA testing not only helps identify men in whom a prostate biopsy would be appropriate but also assists in assessing the response to therapy, determining tumor progression, and, in its most controversial role, screening for prostate cancer. (medscape.com)

These observations suggest that GCC signaling may regulate the renewal of the intestinal epithelium by restricting the proliferating compartment and promoting the transition from proliferation to differentiation along the crypt to villus axis. (jefferson.edu)
Gene enrichment analysis revealed that these lncRNA-related mRNAs are associated with cell adhesion, collagen adhesion, cell differentiation, and mainly enriched in ECM-receptor interaction and PI3K-Akt signaling pathways. (biomedcentral.com)
Recent advances in live imaging and genetics of mammalian division, movement and cell differentiation leading to development which integrate observations of biochemical tissue formation [14 ]. (lu.se)

Monocarboxylate transporter 4 (MCT4, SLC16A3 ) is elevated under hypoxic conditions in many malignant tumors including gliomas. (hindawi.com)
In recent years, the utilization of Chinese native medicine and other plant extracts in the treatment of diseases has attracted extensive attention, especially in the area of malignant tumors. (hindawi.com)
With the changes of the diet types and the bad living habits, malignant tumors have gradually developed into a serious threat to human health and life. (hindawi.com)
Oral cancer is one of the most prevalent malignant tumors worldwide. (jcancer.org)
Colorectal cancer (CRC), including colon cancer and rectal cancer, is one of the most common malignant tumors. (biomedcentral.com)
According to the latest global cancer statistics 2018, CRC has risen to the rank third of malignant tumors and when it comes to the cancer mortality, CRC ranks second, ahead of the stomach cancer and liver cancer [ 3 ]. (biomedcentral.com)

Finally, MCT4 inhibition mitigates the induction of angiogenesis, suggesting that MCT4 also plays a crucial role in tumor-related angiogenesis. (hindawi.com)
For this purpose, we designed an MCT4 overexpression and knockdown/inhibition model to explore the functional consequences of MCT4 expression on cancer cell metabolism, survival, proliferation, migration, invasion potential, and angiogenesis as well as on cell cycle profiles and cell death mechanisms. (hindawi.com)
Transcriptional coactivator Yes-associated protein (YAP) can promote the proliferation of multiple cancer cells, corneal endothelial cells, and vascular smooth muscle cells, which participate in angiogenesis. (molvis.org)
Mechanism of miR-455-3 in suppressing epithelial-mesenchymal transition and angiogenesis of non-small cell lung cancer cells. (nih.gov)
Inhibits migration, proliferation and network formation by endothelial cells as well as angiogenesis. (novusbio.com)
Does not affect the proliferation of cancer cells in vitro, but inhibits tumor growth and tumor angiogenesis. (novusbio.com)

Distinct hallmarks of cancer were examined using in silico analysis, various in vitro cell culture assays, and ex vivo organotypic rat brain slice culture model. (hindawi.com)
We investigated the impact on tumor malignancy in F98 glioma cells using in silico analysis, in vitro cell culture assays, and ex vivo vascular organotypic glioma impact model (VOGIM) [ 35 ] by implanting F98 cells into rat brain slices. (hindawi.com)
Background/Aim: Demethoxycurcumin (DMC), a derivate of curcumin from natural plants, exerts antitumor effects on various human cancer cells in vitro and in vivo. (iiarjournals.org)
Additionally, DRAM2 overexpression promoted cell metastasis and proliferation in vitro, while knockdown of DRAM2 expression yielded opposite result. (cancerindex.org)
We aimed to examine the molecular processes underlying the effects of silibinin in oral cancer in vitro and in vivo as well as its potential anticancer effects. (jcancer.org)
Next, we investigated the molecular processes underlying both in vitro and in vivo outcomes of silibinin treatment on oral cancer. (jcancer.org)
The upregulation of BCL6 may significantly inhibited the proliferation and metastasis of GC cells in vitro and in vivo. (bvsalud.org)
Selenium has been reported to inhibit the growth of prostate cancer cells in vitro. (positivehealth.com)
Stem cell senescence in the in vitro expansion stage is an essential concern in clinical procedures of cell therapy. (magiran.com)
Cell proliferation, migration, and invasion assays were performed to evaluate the effects of miR-320d on GCA cells after transfection in vitro. (biomedcentral.com)
In close agreement, induction of GCC signaling in mucosal sheets ex vivo and intestinal cells in vitro inhibited proliferation by activating cGMP-dependent protein kinase and delaying the cell cycle at the G1/S transition. (jefferson.edu)
Herein, we demonstrated that BEX2 knockout resulted in enhanced migratory and metastatic potential in colorectal cancer cells both in vitro and in vivo, and re-expression of BEX2 in knockout cells could reverse the enhanced migratory capacity. (ijbs.com)
In this study, we established that miR-296-5p has a significantly lower expression in NPC tissues and cells and was involved in regulating the EMT and metastasis of NPC cells in vitro. (biomedcentral.com)

BACKGROUND: B-cell lymphoma 6 (BCL6) is a transcription repressor that plays a tumor suppressor or promoting role in various tumors. (bvsalud.org)
Caveolin-1 regulates anchorage-dependent growth and is a tumour suppressor. (europa.eu)
These results may provide a molecular explanation for the role of caveolin-1 as tumour suppressor and provide insight into the mechanism of anchorage-independent growth, one of the hallmarks of cancer. (europa.eu)
miR-21 has both oncogenic and onco-suppressor functions and most of the experiments are in agreement with the tumor-promoting function of this miRNA. (drtaheriazam.com)
PTEN (phosphatase and tensin homolog deleted on chromosome 10) belongs to a cancer suppressor gene (one of the protein phosphatases). (aging-us.com)
Taken together, our data suggested that miR-320d acts as a tumor suppressor in GCA by directly targeting FoxM1 and thus potentially serves as a biomarker for anti-GCA therapy in GCA patients. (biomedcentral.com)
This previously unrecognized role of GCC as a tumor suppressor by restricting proliferation and maintaining genomic integrity suggests that receptor dysregulation reflecting ligand insufficiency is a key event during early colorectal tumorigenesis. (jefferson.edu)
Together with the uniform over-expression of GCC in human tumors, and the standard of care in which hormone deficiencies are treated by replacement therapy, the role of GCC as a tumor suppressor underscores the potential of oral administration of GCC ligands for targeted prevention and therapy of colorectal cancer. (jefferson.edu)
It is mutated in a variety of cancers and is believed to be a tumor suppressor. (frontiersin.org)
Strikingly, contrary to its role as a tumor suppressor, excessive SETD2 results in the upregulation of cell cycle-associated pathways. (frontiersin.org)

The ncRNAs regulate various molecular pathways and mechanisms in cancer that can lead to induction/inhibition of carcinogenesis. (drtaheriazam.com)
Furthermore, KIN17 is associated with cancer cell proliferation, migration, invasion and cell cycle regulation by regulating pathways including the p38 MAPK, NF‑κB‑Snail and TGF‑β/Smad2 signaling pathways. (spandidos-publications.com)
The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
I thus uncover these circuits of connected drivers which cause tumorigenesis through the perturbation of overlapping cellular pathways in a pan-cancer manner across 15 malignancies. (biomedcentral.com)
An evolving paradigm expanding the genetic basis of cancer suggests that developmental programs indelibly imprint restricted repertoires of homeostasis, forming the substrate for lineage-dependent tumor induction by deregulation of tissue-specific survival pathways. (jefferson.edu)
Furthermore, activated miR-146a inhibited cancer migration, invasion, and metastasis by downregulating vascular endothelial growth factor through dual pathways in HCC. (biomedcentral.com)
BEX proteins have been reported to be involved in transcriptional regulation and signaling pathways in neurodegeneration, cell cycle and tumor growth [ 5 - 8 ]. (ijbs.com)

The mechanism behind malignancy and tumor genesis is unknown, limiting development of alternative therapies. (nature.com)
In summary, our data highlight MCT4 /SLC16A3 as a key gene for distinct hallmarks of tumor malignancy in glioma cells. (hindawi.com)
Oral cancer is a common malignancy of the head and neck region [ 1 ], with more than 350,000 new cases and 177,000 deaths annually recorded worldwide [ 2 ]. (jcancer.org)
Increasing evidence suggested EMT was involved in cancer invasion, metastasis ( 16 ) and the malignancy of tumors ( 17 ), often marked by reduction of E-cadherin and induction of N-cadherin ( 18 ). (spandidos-publications.com)
We searched the databases such as EMBASE, PubMed, and Web of Science with the keywords "stem cell," "progenitor cell," "satellite," "senescence" and excluded the keywords "cancer," "tumor," "malignancy" and "carcinoma" until June 2020. (magiran.com)

In the past years, a large number of studies have demonstrated that Polygonum cuspidatum and its active components like resveratrol showed excellent antitumor activities, including our own antitumor studies about resveratrol in colorectal cancer. (hindawi.com)
Previous researches completed by our team have also demonstrated that resveratrol inhibits the proliferation, invasion, and metastasis of colorectal cancer cells [ 5 ]. (hindawi.com)
Most cases of colorectal cancer in adolescents and young adults are sporadic, but several genetic syndromes are associated with these tumors in young patients. (medscape.com)
Surgical treatment of metastatic colorectal cancer offers a chance for cure or prolonged survival. (medscape.com)
Colorectal cancer (CRC) is the most common cancer of the gastrointestinal (GI) tract. (medscape.com)
With these data it is not yet possible to speak of a cure or safe prevention of colorectal cancer thanks to strawberry tree honey," emphasizes Battino, who adds: "This work constitutes a starting point in the effort to evaluate its possible biological and anti-cancer effects and indicates the main molecular mechanisms through which it exerts its effect, reinforcing the interest in the study and production of this Mediterranean foodstuff. (agenciasinc.es)
Colorectal cancer (CRC) is one of the most common tumors, and its five-year survival is still very low despite of the advance of treatment strategies. (jcancer.org)
Colorectal cancer (CRC) is a common public health problem, being one of the most common gastrointestinal tumors in the world [ 1 , 2 ]. (jcancer.org)
Liu Y , Sun M , Zhang B , Zhao W , . KIF18A improves migration and invasion of colorectal cancer (CRC) cells through inhibiting PTEN signaling. (aging-us.com)
However, we have never known the influences of KIF18A on colorectal cancer (CRC). (aging-us.com)
Based on the Global Cancer Statistics Report, colorectal cancer (CRC) is currently the third most common cancer and the second leading cause of cancer death [ 1 ]. (aging-us.com)
Although these results support the potential development of fucoidan as an anticancer drug, there is little information on the anticancer effect of fucoidan on colorectal cancer (CRC). (iiarjournals.org)
The incidence of colorectal cancer is increasing, and cancer metastasis is one of the major causes of poor outcomes. (ijbs.com)
BEX2 has been reported to be involved in tumor development in several types of cancer, but its role in metastatic colorectal cancer remains largely undefined. (ijbs.com)
moreover, the hedgehog signaling inhibitors, GANT61 and GDC-0449 could reverse the migratory enhancement of BEX2-/- colorectal cancer cells. (ijbs.com)
In summary, our findings suggest that BEX2 negatively modulates the hedgehog signaling pathway by retaining Zic2 in the cytoplasm in colorectal cancer cells, thereby inhibiting migration and metastasis of colorectal cancer cells. (ijbs.com)
Colorectal cancer (CRC) is one of the most common types of cancer, with a high disease-related mortality among all cancers [ 1 , 2 ]. (ijbs.com)

Our results further indicate that MCT4 promotes proliferation and survival by altered cell cycle regulation and cell death mechanisms. (hindawi.com)
Besides, upregulated MCT4 has been linked to altered tumor metabolism as well as to increased growth and survival in breast and pancreatic cancer [ 33 , 34 ]. (hindawi.com)
However, there has only been one previous functional study investigating MCT4 in glioblastoma (GBM) neurospheres, mainly focusing on tumor growth and survival dependent on the oxygen level [ 14 ]. (hindawi.com)
Here, we found that intracellular HMGB1 was consistently upregulated in LUAD specimens, and positively relevant to tumor grade and poor survival. (bvsalud.org)
However, the usefulness of SCNA for predicting the survival of patients treated with cytokine-induced killer (CIK) cells or chemotherapy (CT) is unknown. (bvsalud.org)
Meanwhile, EERAC remarkably reversed the effects of mastermind like transcriptional coactivator 1 (MAML1, activator of notch-signaling pathway) on cell survival of SW480. (jcancer.org)
The bad prognosis induced tumor metastases and invasion leads to the low five-year survival rate of CRC patients [ 3 ]. (jcancer.org)
At present, the diagnosis and prognosis of lung cancer remain poor, and the survival rate of lung cancer has only slightly improved over the past few decades [ 6 ]. (biomedcentral.com)
For example, data show that the average five-year survival rate for lung cancer patients in the United States is 19% [ 7 ]. (biomedcentral.com)
Autophagy is a molecular "self-digestion" mechanism its function can be pro-survival or pro-death in tumor cells. (drtaheriazam.com)
Both the Kaplan‑Meier survival analysis and multivariate Cox regression analysis indicated that KIN17 is aberrantly high expressed in various tumor tissues and is also associated with poor prognosis in patients with various tumor types. (spandidos-publications.com)
Among them, VEGF-A can promote the division and proliferation of vascular endothelial cells and neovascularization and maintain the survival of new vessels. (molvis.org)
We proposed that hypoxic preconditioning could increase survival of bone marrow mesenchymal stem cells (MSCs) via upregulation of Pim-1 and aimed to determine the microRNAs that modulate the expression of Pim-1. (biomedcentral.com)
9 ] reported that hypoxic preconditioning increases survival of cardiac progenitor cells via upregulation of Pim-1, discovering a method for nongenetic modification of Pim-1 in stem cells. (biomedcentral.com)
Arguments supporting the reactive nature of LCH include the occurrence of spontaneous remissions, the extensive elaboration of multiple cytokines by dendritic cells and T-cells (the so-called cytokine storm) in LCH lesions, and the good survival rate in patients without organ dysfunction. (medscape.com)
Despite methodological differences, findings evidence that although IBC presents particular features (lower survival rate and worse prognostics than most types of breast cancer), very few studies examine its epidemiology and specific risk factors in depth and use any other therapeutic approaches than those commonly used for other breast cancer subtypes. (bvsalud.org)
With an average survival rate of three years, IBC accounts for about 2.5% of all breast cancer types in the US. (bvsalud.org)
Despite the apparent survival advantage conferred by PSA screening, the US Preventive Services Task Force (USPSTF) recommends against screening for prostate cancer in men aged 75 years or older. (medscape.com)

But these treatments, to some extent, easily produce side effects on normal cells, organs, and other tissues of the human body, thus accelerating the death process of cancer patients. (hindawi.com)
DRAM2 was preferentially upregulated in NSCLC tissues and higher expression of DRAM2 in NSCLC correlated with tumor node metastases stage and lymph node metastasis. (cancerindex.org)
Our transcriptome analysis revealed in bladder cancer (BCa) tissues a significant induction of lysosomal-associated multispanning membrane protein 5 (LAPTM5), a lysosomal membrane protein preferentially expressing in immune cells and hematopoietic cells. (spandidos-publications.com)
Immunohistochemical analysis revealed that there were significant differences in the expression of KIN17 between cancer tissues and adjacent tissues. (spandidos-publications.com)
Our results showed that DEPDC1 was overexpressed at both mRNA and protein levels in NPC tissues compared with normal or non-tumor tissues. (oncotarget.com)
Here, we evaluated expression profile of miR-320d and FoxM1 in 60 human GCA tissues and GCA cell lines (OE-19 and SK-GT2). (biomedcentral.com)
Herein, we aimed to demonstrate the expression of miR-146a and FLAP in human HCC tissues and liver cancer cell lines. (biomedcentral.com)
We demonstrated that miR-146a expression is overexpressed, while FLAP protein and mRNA are suppressed in hepatocellular carcinoma tissues and HepG2 cells compared to para-carcinoma tissues and HL-7702 cells. (biomedcentral.com)
The expressions of miR-296-5p in NPC tissues and cells were determined using GSE32920 database analysis and real-time PCR and miRNA microarray assays. (biomedcentral.com)

Treatment with alpha-tocopherol succinate (VES) inhibits NF-kappaB but augments AP-1 activity, reduces expression of IL-6, IL-8, and VEGF, suppresses cell adhesion, ICAM-1 and gp130 expression in androgen-independent PC-3, DU-145, and CA-HPV-10 cells. (positivehealth.com)
Vitamin E succinate inhibits NF-kappaB and prevents the development of a metastatic phenotype in prostate cancer cells: implications for chemoprevention. (positivehealth.com)
Integrin-mediated retention of phosphorylated caveolin in focal adhesions inhibits raft internalisation, which occurs upon its recruitment to caveolae after cell detachment. (europa.eu)
Hu W, Wu C, Yuan C, Chen M, Jin C, Zheng C. Ethanol Extracted from Radix of Actinidia Chinensis Inhibits Human Colon Tumor Through Inhibiting Notch-signaling Pathway. (jcancer.org)
Our results show that miR-296-5p inhibits the migratory and invasive capacities of NPC cells by targeting TGF-β, which suppresses EMT. (biomedcentral.com)
Vinblastine inhibits microtubule formation, which, in turn, disrupts the formation of a mitotic spindle, causing cell proliferation to arrest at metaphase. (medscape.com)
Etoposide inhibits topoisomerase II and causes DNA strand breakage, causing cell proliferation to arrest in the late S or early G2 portion of the cell cycle. (medscape.com)
Mercaptopurine is a purine analog that inhibits DNA and RNA synthesis, causing cell proliferation to arrest. (medscape.com)
Methotrexate is an antimetabolite that inhibits DNA synthesis and cell reproduction in malignant cells. (medscape.com)

Furthermore, silibinin inhibited the migration and invasion abilities of YD10B and Ca9-22 cells by regulating the expression of proteins involved in the epithelial-mesenchymal transition. (jcancer.org)
Role of mesothelin in carbon nanotube -induced carcinogenic transformation of human bronchial epithelial cells. (cdc.gov)
In this study, the role of MSLN in the carcinogenic transformation of human bronchial epithelial cells chronically exposed to single-walled CNT (BSW) was investigated. (cdc.gov)
Together, our results indicate a novel role of MSLN in the malignant transformation of bronchial epithelial cells following CNT exposure, suggesting its utility as a potential biomarker and drug target for CNT-induced malignancies. (cdc.gov)
Annexin A2 and S100A10 as Candidate Prognostic Markers in Epithelial Ovarian Cancer. (cancerindex.org)
The aim of this study was to examine whether Annexin A2 and S100A10 expression can be used as prognostic markers for epithelial ovarian cancer (EOC). (cancerindex.org)
During EMT, cells will undergo transformation from epithelial phenotype to mesenchymal phenotype ( 14 ) and many characteristics of cells will change including loss of cell-cell adhesion and acquisition of aggressive and metastatic ability ( 15 ). (spandidos-publications.com)
Lung cancer is the most common form of cancer worldwide and originates in the epithelial cells of the respiratory tract [ 1 ]. (biomedcentral.com)
Microcrystalline silica particles induce inflammatory response via pyroptosis in primary human respiratory epithelial cells. (nih.gov)
Separately, deletion of GCC increased tumor growth by releasing a restriction on the cell cycle normally constraining epithelial cell proliferation. (jefferson.edu)
Other particles may be engulfed by epithelial cells, primarily in the vicinity of the bronchial-alveolar duct junctions, and retained for much longer periods, with gradual removal to lymph nodes. (cdc.gov)

AKAP12 knockdown in benign meningioma cells SF4433 increases proliferation, cell cycle, migration, invasion, and confers an anaplastic profile. (nature.com)
Stable F98 glioma cell lines with MCT4 overexpression, normal expression, and knockdown were generated. (hindawi.com)
Transwell migration, cell cycle analysis, MTT and colony formation assays were performed to determine the effect of DRAM2 overexpression and knockdown on NSCLC-cell migration and proliferation. (cancerindex.org)
The functional role of MSLN in the BSW cells was then investigated by using stably transfected MSLN knockdown (BSW shMSLN) cells. (cdc.gov)
MSLN knockdown resulted in significantly decreased invasion, migration, colonies on soft agar, and tumor sphere formation. (cdc.gov)
Furthermore, we established a BCa cell model with downregulated LAPTM5, revealing a significantly delayed growth rate in the BCa cells with knockdown of LAPTM5. (spandidos-publications.com)
Furthermore, previous studies suggested that knockdown of LAPTM4B , another important subtype of the LAPTM family inhibited proliferation of hepatocellular carcinoma ( 11 ), prostate ( 12 ) and breast cancer cells ( 13 ). (spandidos-publications.com)
Considering that a host of intracellular proteins are affected by proteasome inhibition, coupled with evidence that knockdown of MKP3 expression enhances growth factor-stimulated ERK phosphorylation in some contexts [13] but not in others [16], led us to question whether or not the diminution of ERK signaling in MG132-treated cells could be attributed solely to upregulation of MKP3 and other DUSPs. (scienza-under-18.org)
In addition, knockdown of KIN17 was found to enhance the sensitivity of tumor cells to chemotherapeutic agents. (spandidos-publications.com)
Consistent with its regulatory role in NF-κB pathway, knockdown of DEPDC1 caused significant upregulation of A20 and downregulation of mutiple NF-κB downstream target genes implicated in proliferation and tumorigenesis (c-Myc, BCL2, CCND1, CCNB1 and CCNB2), and metastasis (MMP2, MMP9, ICAM1, vimentin, Twist1). (oncotarget.com)
Moreover, in vivo study demonstrated that DEPDC1 knockdown also caused significant inhibition of tumor growth in the NPC xenograft nude mouse model. (oncotarget.com)
Knockdown of miR-146a also resulted in increased FLAP expression of cancer cells. (biomedcentral.com)
We also demonstrated that the nuclear translocation of Zic2 after BEX2 silencing could activate the hedgehog signaling pathway, while Zic2 knockdown abrogated the migratory enhancement of BEX2-/- cells and inhibited the hedgehog signaling pathway. (ijbs.com)

Moreover, MCT4 overexpression enhances cell migration and invasiveness via reorganization of the actin cytoskeleton. (hindawi.com)
LPA receptors and ATX are upregulated in numerous cancer cell types and show expression patterns that correlate with tumor cell invasiveness. (betalifesci.com)
Silencing PDL-1 expression suppressed CAFs' ability to promote stem cell-like properties and invasiveness of lung cancer cells, favoring chemoresistance. (cdc.gov)

Therefore, screening new Chinese medicine active components and determining their antitumor effects have become a new breakthrough in the prevention and treatment of tumor disease. (hindawi.com)
Many natural products and their active components have been reported to have potential antitumor or tumor preventive properties. (hindawi.com)
Therefore we investigated the antitumor effects of DMC on a HeLa cell xenograft model in nude mice in this study. (iiarjournals.org)
The antitumor effect of ethanol extracted from radix of Actinidia chinensis (EERAC) were identified in human colon cancer cells, but the underlying mechanism remains unclear. (jcancer.org)
Cannabinoids were shown to have antitumor properties, prevent tumor cell proliferation, induce tumor cell death, prevent the formation of new malignant tumor cells, and prevent secondary cancer growth sites from establishing (Dariš, Tancer, Knez, Ferk, 2019). (beescannafarm.com)
ATX has been found to catalyze the formation of cyclic phosphatidic acid (cPA), which have antitumor role by antimitogenic regulation of cell cycle, inhibition of cancer invasion and metastasis. (betalifesci.com)

The significant inhibition of tumor growth by EERAC was also observed. (jcancer.org)

Taken together, KIN17 has key roles in tumorigenesis and cancer development. (spandidos-publications.com)
The above biological processes have important roles in tumorigenesis, cancer development and chemoresistance in tumor cells. (spandidos-publications.com)
Large tumor genome sequencing projects have now uncovered a few hundred genes involved in the onset of tumorigenesis, or drivers, in some two dozen malignancies. (biomedcentral.com)
First, I explore their involvement in tumorigenesis as mutational drivers in 28 different tumor types. (biomedcentral.com)
First, while the most frequent drivers in these lists have been long known and studied in their involvement in tumorigenesis, many novel mid- and low-frequent drivers have emerged whose roles in cancer need to be systematically clarified. (biomedcentral.com)

Results: DMC significantly reduced tumor weights and volumes of HeLa cell xenografts in mice, indicating the suppression of growth of xenograft tumors. (iiarjournals.org)
Silibinin significantly inhibited xenograft tumor growth in nude mice, with no obvious toxicity. (jcancer.org)
Importantly, silibinin effectively suppressed xenograft tumor growth in nude mice. (jcancer.org)
Xenograft tumor assay was applied to detect the influence of EERAC on tumor growth. (jcancer.org)
In vivo experiments were conducted using a co-implantation xenograft mouse model with live cell imaging and immunohistochemistry. (cdc.gov)

Silibinin has been reported to exert therapeutic effects in various cancer models. (jcancer.org)
Actinidia chinensis has presented promising therapeutic effect on several types of cancers including breast, liver, and gastric cancer [ 10 , 11 ]. (jcancer.org)
There are a number of therapeutic modalities for cancer such as chemotherapy, radiotherapy and surgery. (drtaheriazam.com)
The present review was the first, to the best of our knowledge, to systematically summarize and clarify the relevance between KIN17 and tumor development from different aspects ( Table I ), including the structure, function, expression level and regulatory mechanisms of KIN17, so as to explore the potential of KIN17 as a tumor diagnostic and prognostic biomarker and as a potential therapeutic target. (spandidos-publications.com)
The present study aimed to summarize the influence of KIN17 on tumor development and the possibility of KIN17 as a tumor diagnostic and prognostic biomarker and as a potential therapeutic target. (spandidos-publications.com)
DEP domain containing 1 (DEPDC1) is a newly identified cancer-related and cell cycle related gene and has been demonstrated as a novel therapeutic target for bladder cancer. (oncotarget.com)
Cannabinoids in cancer treatment: Therapeutic potential and legislation. (beescannafarm.com)
The systematic detection of these circuits may be key to propose novel therapeutic strategies indirectly targeting driver alterations in tumors. (biomedcentral.com)
Furthermore, we provide evidence for the therapeutic application of PrP c silencing with other anticancer drugs for cancer. (iiarjournals.org)
It also contributes significantly to cancer-related deaths, despite continuous progress in developing diagnostic and therapeutic methods ( 15 ). (iiarjournals.org)
Thus, miR-146a may be a tumor promoter and a potential therapeutic target for the treatment of HCC patients. (biomedcentral.com)

Transcreener assays are not validated with cell lysates, blood, serum, or other biological samples. (bellbrooklabs.com)
Investigating the histological characteristics of CRC is conducive to the research of the biological characteristics of tumors. (aging-us.com)
CCK-8, transwell, wound-healing assays, and in vivo experiments were conducted using GCA cells that treated with miR-320d mimics or inhibitors to evaluate the biological functions of miR-320d. (biomedcentral.com)
The mechanism analysis of miR-320d/FoxM1 showed that FoxM1 has two miR-320d binding sites in its 3′-untranslated region (3′-UTR), that contributes to regulation of the cell biological behaviors. (biomedcentral.com)

Overexpression of this gene is associated with tumor cell proliferation and metastasis. (cancerindex.org)
DRAM2 overexpression also increased proteins CDK4, CyclinD3, and decreased p27 expression, all of which are cell cycle-related factors. (cancerindex.org)
MSLN overexpression was found in human lung tumors, lung cancer cell lines, and BSW cells. (cdc.gov)
ERK signaling is usually inappropriately activated in a wide array of human cancers, which can be caused by an activating mutation in one of the upstream signaling proteins or through overexpression of growth factors or growth factor receptors [7], [8]. (scienza-under-18.org)
Overexpression of Pim-1 in stem/progenitor cells stimulated cell cycling and enhanced cardiac regeneration in vivo. (biomedcentral.com)

Besides, many studies have proved that ethanol extract from radix of Actinidia chinensis (EERAC) has an obviously curative effect on several types of tumors including hepatocellular carcinoma and lung cancer, [ 15 - 17 ]. (jcancer.org)
Hepatocellular carcinoma (HCC) is a primary liver cancer with high incidence rate, especially in regions with high prevalence of viral hepatitis infection. (drtaheriazam.com)

Results: Fucoidan treatment significantly inhibited growth and reduced cyclin and cyclin-dependent kinase (CDK) expression in HT29 colon cancer cells. (iiarjournals.org)

Cdk5 is a proline-directed serine/threonine kinase, which was first identified as a CDK family member due to its similar structure to CDC2/CDK1 in humans, a protein that plays a crucial role in the regulation of the cell cycle. (wikipedia.org)
The functional regulation of cells is a complex and dynamic process. (nature.com)
Moreover, some studies demonstrated that LAPTM5 was highly expressed in malignant B lymphomas and involved in B cell malignancies ( 10 ), involving in negative regulation of cell surface T and B cell receptor by promoting lysosome degradation ( 6 ). (spandidos-publications.com)
equally central to the regulation of cell signaling. (scienza-under-18.org)
But changes in the expression of lymphocyte migration regulation related proteins in urine exosomes remain unclear. (biomedcentral.com)
Mass spectrometry was used to screen and explore the expression changes of lymphocyte migration regulation related proteins in healthy people of different ages. (biomedcentral.com)
Enzyme-linked immunosorbent assay and western blotting were used to detect the expression changes of lymphocyte migration regulation related proteins in lung cancer patients. (biomedcentral.com)
Analyzing the data of urine exosome proteomics, a total of 12 lymphocyte related proteins were identified, 5 of which were lymphocyte migration regulation related proteins. (biomedcentral.com)
Lymphocyte migration regulation related proteins were differentially expressed in the urine exosome of lung cancer patients, and WASL, STK10 and WNK1 may serve as potential biomarkers for lung cancer diagnosis. (biomedcentral.com)
It has been shown that the effective response of the immune system depends on the regulation of lymphocyte migration and homing in many ways. (biomedcentral.com)
KIN17, which is known as a DNA and RNA binding protein, is highly expressed in numerous types of human cancers and was discovered to participate in several vital cell behaviors, including DNA replication, damage repair, regulation of cell cycle and RNA processing. (spandidos-publications.com)
Previous studies have indicated that KIN17 is involved in global genome repair, DNA replication, transcription and regulation of the cell cycle as part of a multi-protein complex. (spandidos-publications.com)
and regulation of cell cycle process. (nih.gov)

We aim to study the coupling between LTCC and β adrenergic receptors in different cardiomyocyte microdomains, the distinct involvement of PKA and CAMKII (Ca2+/calmodulin-dependent protein kinase II) and explore how this functional complex is disrupted in heart failure.Methods:Global signaling between LTCCs and β adrenergic receptors was assessed with whole-cell current recordings and western blot analysis. (imperial.ac.uk)
Therefore, the full utilization of some natural products and their active components will provide unique ideas and methods for cancer prevention and treatment. (hindawi.com)
Materials and Methods: Twenty-four nude mice were subcutaneously injected with HeLa cells. (iiarjournals.org)
METHODS: Firstly, BCL6 was identified as an important biomarker that attenuated the proliferation and metastasis of GC through tumor microarrays and confirmed in GC cell lines. (bvsalud.org)
Materials and Methods: PrP c expression was suppressed in HT29 human colon cancer cells by utilizing small-interfering RNA (si-PRNP), and cells were subsequently used to study the antiproliferative and anticancer effects of fucoidan treatment of HT29 human colon cancer cells. (iiarjournals.org)
These results demonstrate differential sensitivity of standard cytotoxicity assessments on the PPP, thus (1) decoupling 'mitochondrial activity' as an interpretation of cellular formazan and Alamar Blue metabolism, and (2) demonstrating the implicit requirement for investigators to sufficiently verify interaction of these methods in routine cytotoxicity and proliferation characterization. (cdc.gov)

Phosphorylations are of vital importance during glycolysis, therefore, making kinases an essential part of the cell due to their role in the metabolism, cell signaling, and many other processes. (wikipedia.org)
In the metabolic symbiosis model, these cells have been proposed to overexpress MCT4 to release high amounts of lactate produced during anaerobic glycolysis into the tumor microenvironment. (hindawi.com)
This led to other relevant results, such as the reduction of some transcription factors, the inhibition of the activity of certain enzymes and the decrease of mitochondrial respiration and glycolysis of tumour cells. (agenciasinc.es)
Activation of PI3K/Akt signaling promotes glucose uptake, favors glycolysis and increases tumor cell proliferation. (drtaheriazam.com)

The BJBMS stated that cannabinoids displayed anti-tumor effects against various types of cancers in animal and cell cultures, which further displayed their anti-cancer properties (Dariš, Tancer, Knez, Ferk, 2019). (beescannafarm.com)
MicroRNAs (miRNAs) negatively regulate gene expression post-transcriptionally by binding to the 3'-untranslated region (3'-UTR) of the target mRNA sequences and have been shown to be involved in various types of cancers. (biomedcentral.com)

However, its mechanism of action in oral cancer remains unclear. (jcancer.org)
However, its function and molecular mechanism in gastric cancer (GC) remain unclear. (bvsalud.org)
Cell death, lipid peroxidation, MDA and Fe2+ level were detected to determine the effect of BCL6 on ferroptosis and the mechanism was revealed. (bvsalud.org)
Our findings propose a potential mechanism of VES-mediated anti-tumour activity and support the role of vitamin E analogs as potential chemopreventative agents against prostate cancer. (positivehealth.com)
The main goal of this research proposal is to study the relevance of this novel mechanism to cancer. (europa.eu)
The ubiquitin-proteasome pathway is an essential quality control mechanism directing degradation of mislocated, misfolded, and damaged proteins, and, by tempering the expression levels Carnosol of specific signaling proteins, it also exerts a level of control over cell physiology [1]. (scienza-under-18.org)
The migration of lymphocytes shares many similarities in mode and mechanism with the metastasis of lung cancer tumor cells. (biomedcentral.com)
Preclinical evaluation of these nanoaggregates is discussed with a special focus on the investigation of their mechanism of action at a molecular level, highlighting their pharmacological potential in tumor disease models and value for biomedical applications. (mdpi.com)
To explore the effect of miR-296-5p on the metastasis of nasopharyngeal carcinoma (NPC) cells and investigate the underlying mechanism. (biomedcentral.com)
This study revealed a novel mechanism by which miR-296-5p regulates the EMT and metastasis of NPC cells, indicating that it could be a new target for the treatment of NPC. (biomedcentral.com)

Binding of PD-L1 to its receptors suppresses T-cell migration, proliferation and secretion of cytotoxic mediators, and restricts tumour cell killing. (nih.gov)
DRAM2 acts as an oncogene in non-small cell lung cancer and suppresses the expression of p53. (cancerindex.org)

Malignant gliomas are the most common primary malignant brain tumors with an increasing incidence of up to nine per 100,000 habitants over the last years [ 1 , 2 ]. (hindawi.com)

Mesothelin (MSLN) is overexpressed in many human tumors, including mesotheliomas and pancreatic and ovarian carcinomas. (cdc.gov)

Many patients are not diagnosed until the middle and late stages of the disease, so there is an urgent need to find new tumor markers and more sensitive indicators for assessing patient prognosis to find new targets and directions for lung cancer diagnosis and treatment. (biomedcentral.com)
Conventional treatment options in oral cancer have resulted in relatively poor prognosis and an unmet need of treatment. (brjnmims.org)
Recombinant Kinesin Family, Member 18A ( KIF18A ) belongs to Recombinant Kinesin Family [ 9 ], which is highly expressed in tumors and associated with poor prognosis [ 10 , 11 ]. (aging-us.com)
In this study, we verified the prognosis value of miR-320d in human GCA tissue, and identified its expression level in GCA specimens, GCA cell lines, and GCA tumor-bearing mice. (biomedcentral.com)

Nevertheless, no reports have disclosed whether DMC can affect the growth of human cervical cancer cells in vivo. (iiarjournals.org)
In vivo, BSW shMSLN cells formed smaller primary tumors and less metastases. (cdc.gov)
The authors hope that these promising results and the anti-tumour potential of this food will be confirmed in in vivo models. (agenciasinc.es)
None of these effects was observed when honey was applied to healthy cell lines," the authors point out, noting the anticarcinogenic potential of this natural product, but insisting on the need for new studies with colon cancer in vivo models to confirm its chemopreventive effects. (agenciasinc.es)

Furthermore, responses were associated with T-helper type 1 (TH1) gene expression, CTLA4 expression and the absence of fractalkine (CX3CL1) in baseline tumour specimens. (nih.gov)
Tumor specimens from 259 NSCLC patients were collected and analyzed. (cancerindex.org)

Spanish and Italian researchers have proven that when honey from strawberry trees, a product typical of Mediterranean areas, is added to colon cancer cells grown in the laboratory, cell proliferation is stopped. (agenciasinc.es)
Now, scientists from the universities of Vigo and Granada (Spain) and from the Polytechnic University of Marche (Italy) have analysed for the first time the potential of this Mediterranean product to fight colon cancer. (agenciasinc.es)
The cytotoxicity and anti-tumour effects of strawberry tree honey in relation to colon cancer lines increased with the amount and time of treatment. (agenciasinc.es)
Conclusion: Combination of fucoidan with silencing of PrP c has a synergic effect on the inhibition of HT29 colon cancer cell growth. (iiarjournals.org)
Recently, signaling by GCC and its downstream effector, cyclic GMP (cGMP) has emerged as a principal regulator of proliferation in human colon cancer cells. (jefferson.edu)

Furthermore, the expression and function of BCL6 in GC were regulated by the ring finger protein 180 (RNF180)/ras homolog gene family member C (RhoC) pathway, which had been elucidated to be involved in significantly mediating the proliferation and metastasis of GC cells. (bvsalud.org)
LAPMT5 is a lysosomal membrane protein preferentially expressed in immune cells ( 5 , 6 ) and hematopoietic cells ( 7 ), having a close interaction with the Nedd4 ( 8 ), a member of the E3 ubiquitin ligases family ( 8 ). (spandidos-publications.com)
PSMA (prostate specific membrane antigen) PSMA is a cell surface protein that mediates signal transduction processes leading to cell migration. (azbio.org)
Increased expression of FGFR2 protein has been observed in a number of human malignancies, including gastric, lung, ovarian, and breast cancers. (azbio.org)
The Autotaxin protein is important for generating the lipid signaling molecule lysophosphatidic acid (LPA), which is a potent mitogen, which facilitates cell proliferation and migration, neurite retraction, platelet aggregation, smooth muscle contraction, actin stress formation and cytokine and chemokine secretion. (betalifesci.com)
Abnormal expression of 5-Lipoxygenase Activating Protein (FLAP) has been detected in many tumor cells. (biomedcentral.com)
Although SETD2 is functionally important, the protein does not accumulate in human cells. (frontiersin.org)
DeMarini, and Chapter 20, by Rice and cell death determine the size protein in several signal ing path- and Herceg). (who.int)
Prostate-specific antigen (PSA) is a protein produced by normal prostate cells. (medscape.com)

Because colorectal cancer's migration and invasion are one of main factors to the severity of the disease, exploring the molecular mechanisms of proliferation, migration and invasion of CRC cells will contribute to the development of targeted therapy [ 5 ]. (aging-us.com)
This study showed that YAP upregulation promoted CNV formation by upregulating the proliferation of endothelial cells, providing evidence for the molecular mechanisms of CNV and suggesting a novel molecular target for nAMD treatment. (molvis.org)
In this study, we investigated programmed death-ligand 1 (PDL-1) as a potential biomarker for CAF-induced chemoresistance and evaluated its role and the underlying mechanisms of chemoresistance in non-small cell lung cancer (NSCLC). (cdc.gov)
of the most critical events which lead to tissue patterning involves mechanisms going beyond single cells. (lu.se)

Epidemiologic evidence indicates that lower circulating vitamin D levels are associated with a higher risk of ovarian cancer and that vitamin D supplementation is associated with decreased cancer mortality. (mdpi.com)
We conducted a systematic review of the literature on the effects of vitamin D on ovarian cancer cell. (mdpi.com)
Ovarian cancer (OC) is the 5th most common cancer among European women. (cancerindex.org)
Prognostic values of S100 family members in ovarian cancer patients. (cancerindex.org)
While the prognostic value of each individual S100 in ovarian cancer is still elusive. (cancerindex.org)
In current study, we investigated the prognostic value of S100 family members in the ovarian cancer. (cancerindex.org)
For example, taxol and docetaxel were used to treat breast cancer and ovarian cancer, and irinotecan was applied for advanced CRC treatment [ 5 - 7 ]. (jcancer.org)

The aim of the present review is to evaluate the role of ncRNAs in regulating autophagy in gastrointestinal tumors. (drtaheriazam.com)
pendent of those associated with cretory ducts, columnar epithelia the KRAS gene is more frequent- other key mechanistic characteris- lining the gastrointestinal tract and ly mutated in human cancer, which tics of IARC Group 1 carcinogens. (who.int)

Since the advent of PSA evaluation, fewer than 3% of men have metastases at the time of diagnosis, and 75% of men have nonpalpable cancer. (medscape.com)

The present work introduces a computational implementation of some principles of a theory of organism development, namely that the default state of cells is proliferation and motility, and includes the principle of variation and organization by closure of constraints. (nature.com)
Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. (cancerindex.org)
This gene product stimulates the motility of tumor cells, has angiogenic properties, and its expression is upregulated in several kinds of carcinomas. (betalifesci.com)

Here, I focus on driver transcription factors and their connection to tumorigensis in several tumor types through the alteration of the expression of their targets. (biomedcentral.com)

Langerhans cell histiocytosis (LCH) is a group of idiopathic disorders characterized by the presence of cells with characteristics similar to bone marrow-derived Langerhans cells juxtaposed against a backdrop of hematopoietic cells, including T-cells, macrophages, and eosinophils. (medscape.com)

In addition, we found that BCL6 directly binds and transcriptionally represses Wnt receptor Frizzled 7 (FZD7) to inhibit the proliferation, metastasis of GC cells. (bvsalud.org)

The incidence of cervical cancer is increasing worldwide. (iiarjournals.org)
Tobacco and alcohol use increase the development and incidence rates of oral cancer as the main risk factors. (jcancer.org)
nonetheless, the incidence of pediatric colorectal tumors is rising. (medscape.com)
[ 1 ] The incidence of distal colon and rectal tumors is rising at the fastest rate, and rectal tumors are disproportionately represented in the very young age groups. (medscape.com)
A previous prevention trial showed that selenium supplementation was effective in reducing (by 50%) the incidence of prostate cancer. (positivehealth.com)
Oral cancer is a high incidence cancer in Asian countries including India with an annual incidence of 77,003 and is the most common cancer in males (53,842) and fifth most common cancer in females (23,161) in India. (brjnmims.org)
Nasopharyngeal carcinoma (NPC) is a major cause of cancer-related mortality in Southern Asia, especially in southern China, where the annual incidence is as high as 35-50 cases per 100,000 people [ 1 , 2 ]. (biomedcentral.com)
Breast cancer is a public health problem, its incidence increases worldwide. (bvsalud.org)

MiR-455-5p upregulation in umbilical cord mesenchymal stem cells attenuates endometrial injury and promotes repair of damaged endometrium via Janus kinase/signal transducer and activator of transcription 3 signaling. (nih.gov)

Western blotting revealed that silibinin downregulated SOD1 and SOD2 and triggered the JNK/c-Jun pathway in oral cancer cells. (jcancer.org)
We also found that BCL6 promoted lipid peroxidation, MDA and Fe2+ level to facilitate ferroptosis of GC cells by FZD7/ß-catenin/TP63/GPX4 pathway. (bvsalud.org)
The results of Western blot illustrated that KIF18A could forward the migration and invasion of CRC cells, and inhibit PTEN , which promoted the activation of PI3K/Akt signaling pathway, thus bringing about the expression of MMP2 and MMP9 . (aging-us.com)
Therefore, targeting drugs molecules in the PTEN signaling pathway may be another strategy to suppress tumor cells by inhibiting tumor activity [ 7 , 8 ]. (aging-us.com)
The current investigation aimed to demonstrate how interpretation of results from several standard cytotoxicity and proliferation assays vary in dependence on contributions from the pentose phosphate pathway (PPP). (cdc.gov)

Intraperitoneal injection of si-PRNP with fucoidan reduced proliferation and tumor volume in Balb/c nude mice. (iiarjournals.org)

The effects of silibinin on the migration and invasion of oral cancer cells were evaluated using transwell assays. (jcancer.org)
Cell proliferation, migration, and invasion were measured with cell counting kit-8 (CCK-8), wound healing, and transwell assays. (jcancer.org)
In addition, the scratch wound assay and Transwell assay were conducted to detect the effect of KIF18A on the migration and invasion of CRC cells. (aging-us.com)
Both scratch wound assay and Transwell indicated that the migration and invasion of CRC could be promoted by KIF18A . (aging-us.com)
Then, immunofluorescence imaging, scratch wound-healing, transwell migration and invasion assays were used to observe the effects of miR-296-5p on cell metastasis and invasion. (biomedcentral.com)

Not only is m7G involved in the normal physiological metabolism of RNA, but recent research also shows that m7G and related regulators appear to be considerably dysregulated in tumors [ 12 ]. (beds.ac.uk)
It disrupts cell metabolism, causing death to resting and dividing cells. (medscape.com)

Here, we show that DRAM2 may act as an oncogenic regulator in non-small cell lung cancer (NSCLC). (cancerindex.org)
Somatic copy number alterations (SCNA), which are widespread in cancer, can predict the efficacy of immune checkpoint inhibitors in non-small-cell lung cancer (NSCLC). (bvsalud.org)
Flavonoids in Ageratum conyzoides and Chinese herbal formulas Miao-Yi-Ai-Tang have presented significant inhibition on cervical carcinoma and lung cancer, respectively [ 9 ]. (jcancer.org)
Urine exosomes were collected from lung cancer patients and healthy people aged 15-79 years. (biomedcentral.com)
Lung cancer patients had reduced expression of WASL and increased expression of STK10 and WNK1 proteins in urine exosomes compared to normal people. (biomedcentral.com)
Urine exosome WASL, STK10, and WNK1 were diagnosed with lung cancer, with a combined AUC of 0.760. (biomedcentral.com)
Urine exosomes can reflect the pathological state of the body, and as a non-invasive alternative to diagnostic testing, urine exosome is expected to be a non-invasive and convenient biomarker for early detection of lung cancer [ 13 ]. (biomedcentral.com)
With respect to cancer therapy, fucoidan appears to be highly efficient in treating certain types of cancer, including breast, prostate and lung, as well as leukemia ( 10 - 12 ). (iiarjournals.org)
Cancer-associated fibroblasts (CAFs) play a vital role in cancer chemoresistance, but detailed understanding of the process particularly in chemoresistant lung cancer is lacking. (cdc.gov)
For these short fibers, which can be fully engulfed by lung cells and do not dissolve in airway fluids in less than a few weeks, their clearance will be similar to other mineral and vitreous particles. (cdc.gov)

Several types of Traditional Chinese Medicines have been proved to be a potent anti-tumor agent [ 8 ]. (jcancer.org)
Since we have a published medical journal describing the benefits of cannabinoids and the anti-tumor and anti-cancer properties, how come the majority of the public does not know this? (beescannafarm.com)

In 2018, there were an estimated 567,000 new cases and 311,000 deaths from cervical cancer globally ( 3 ). (iiarjournals.org)

This brain tumor type is highly proliferative and shows an infiltrative growth pattern, accounting for the high recurrence rates in patients. (hindawi.com)
An organism's growth and transformation during its life cycle is a tremendously complex succession of processes and events but even a simplistic and limited theory, dealing with only the general trend and generating a broad vision of tissue organization, can drive specific studies and experiments to further inform this field of research. (nature.com)
To investigate the effects of silibinin on the growth of oral cancer cells, cell proliferation and anchorage-independent colony formation tests were conducted on YD10B and Ca9-22 oral cancer cells. (jcancer.org)
Moreover, cell cycle arrest at G0/G1 phase was triggered by decreased LAPTM5 as well, which could lead to delayed BCa cell growth. (spandidos-publications.com)
Integrin signals mediate anchorage-dependence of cell growth, while growth of cancer cells is anchorage-independent. (europa.eu)
These studies will contribute to a better understanding of adhesion-dependent signalling and anchorage-dependence of cell growth, and therefore to the pathogenesis of the malignant disease. (europa.eu)
Accordingly, cells treated with MG132 or other proteasome inhibitors exhibit higher expression of MKP3/DUSP6, an ERK1/2-specific DUSP, accompanied by lower levels of ERK phosphorylation stimulated by growth factors [12]C[14]. (scienza-under-18.org)
SOX2 has capacity of increasing growth and metastasis of cancer cells. (drtaheriazam.com)
The study stated that cannabinoids expressed the ability to control cancer cell growth, invasion, and induce cancer cell death in numerous studies, which displayed the cannabinoids' ability to affect the cancer cells lines (Dariš, Tancer, Knez, Ferk, 2019). (beescannafarm.com)
FGFR2 (fibroblast growth factor receptor 2) FGFR2 is a receptor tyrosine kinase (RTK) that is responsible for mediating a number of intracellular processes culminating in cell growth and proliferation. (azbio.org)
These agents inhibit cell growth and proliferation. (medscape.com)

SOX2 promotes stemness of tumor cells and increases the number of cancer stem cells. (drtaheriazam.com)
Crypt expansion reflected hyperplasia of the proliferating compartment with reciprocal increases in rapidly cycling progenitor cells and reductions in differentiated cells of the secretory lineage, including Paneth and goblet, but not enteroendocrine, cells. (jefferson.edu)

Silibinin effectively suppressed YD10B and Ca9-22 cell proliferation and colony formation in a dose-dependent manner. (jcancer.org)

The main role of Cdk5 when it comes to neurons is to assure proper neuronal migration. (wikipedia.org)
There has been considerable interest in the role of carotenoids in the chemoprevention of cancer. (positivehealth.com)
The current review focuses on the role of SOX2 transcription factor in cancer. (drtaheriazam.com)
Non-coding RNAs (ncRNAs) are commonly dysregulated in disease pathogenesis, and their role in cancer has been well-documented. (drtaheriazam.com)
however, only 5%-10% of the high-risk individuals develop oral cancer, indicating the role of genomic variants in susceptibility to oral cancer. (brjnmims.org)
It is a necessity of cell division and plays a role by regulating microtubule dynamics and chromosome aggregation [ 12 ]. (aging-us.com)
This study showed that miR-146a has a stimulatory role in HepG2 cells and promotes HepG2 cell migration and invasion by targeting FLAP mRNA. (biomedcentral.com)
However, BEX2 appears to exhibit diverse expression patterns and functions in different types of tumors, with conflicting evidence regarding the role of BEX2 in different cancers. (ijbs.com)
Finally, TGF-β expression plasmids were transfected into NPC cells to verify the role of TGF-β in the miR-296-5p-mediated inhibition of nasopharyngeal carcinoma cell metastasis. (biomedcentral.com)

Integrins are key regulators of gene expression, cell proliferation and migration. (europa.eu)

RhoC over-expression has been reported in ductal pancreatic adenosarcoma (Suwa, 1998) and in inflammatory breast cancers (van Golen, 1999). (cancerindex.org)

OBJECTIVES: A cure for cancer is out of reach for most patients due to chemoresistance. (cdc.gov)
RESULTS: We demonstrated that chemotherapy-stimulated CAFs promoted tumorigenic and stem cell-like properties of NSCLC cells, which contribute to their chemoresistance. (cdc.gov)
CONCLUSION: Our results show that PDL-1-positive CAFs modulate stem cell-like properties of NSCLC cells by secreting elevated HGF, thereby promoting chemoresistance. (cdc.gov)

This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. (cancerindex.org)
LIU and COLLEAGUES, Department of Structural & Cellular Biology, Tulane University School of Medicine, New Orleans, LA 70112, USA researched at the molecular level, the inhibition of prostate cancer by selenium. (positivehealth.com)
With the development of tumor molecular heterogeneity theory(12), there are still some patients with GIST who are sensitive to radiotherapy, especially for the patients with advanced stage(13-16).In addition, with the development of imaging technology and modern tissue and organ radiation technology, it has become a reality to concentrate high-dose radiation locally in abdominal cavity tumors(12), which challenges RT's insensitivity to GISTs. (researchsquare.com)
3. Cancer Institute (Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education, Key Laboratory of Molecular Biology in Medical Sciences, Zhejiang Province, China), The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009, China. (ijbs.com)

Anatomy21

Organisms8

Diseases51

Chemicals and Drugs81

Analytical, Diagnostic and Therapeutic Techniques and Equipment44

Phenomena and Processes55

Disciplines and Occupations1

Information Science4

Health Care4

Apoptosis25

Progression39

Differentiation3

Malignant tumors6

Angiogenesis6

Vitro13

Suppressor10

Pathways7

Malignancy5

Colorectal cancer17

Survival18

Tissues9

Inhibits9

Epithelial11

Knockdown13

Invasiveness3

Antitumor6

Significant inhibition of tumor growth1

Tumorigenesis5

Xenograft5

Therapeutic11

Biological4

Overexpression5

Hepatocellular2

Significantly inhibited1

Regulation13

Methods6

Glycolysis4

Types of cancers2

Mechanism10

Suppresses2

Brain tumors1

Human tumors1

Prognosis4

Vivo4

Specimens2

Colon cancer5

Protein9

Mechanisms4

Ovarian7

Gastrointestinal2

Metastases1

Motility3

Alteration1

Hematopoietic cells1

Inhibit the proliferation1

Incidence8

Upregulation1

Pathway5

Nude1

Transwell5

Metabolism2

Lung10

Anti-tumor2

20181

Growth11

Increases2

Colony formation1

Role9

Gene Expression1

Pancreatic1

Chemoresistance3

Molecular4