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  • tumor
  • The only cure for pancreatic cancer is surgery, provided the tumor has not spread and can be removed completely and safely. (bidmc.org)
  • They inhibit the proliferation of 60 cancer cell lines derived from nine different tumor types. (knowcancer.com)
  • SAN FRANCISO - A deadly form of cancer in children, which starts out as a tumor in the eye, can now be treated successfully by a combination of therapies. (eurekalert.org)
  • Albeit kind tumors might be lethal if untreated, because of weight on key organs, as on account of an amiable mind tumor, surgery or radiation are the favored techniques for treating developments which have a very much characterized area. (omicsonline.org)
  • Anticancer medications are utilized when the tumor has spread, or may spread, to all regions of the body. (omicsonline.org)
  • Drugs used in chemotherapy, such as temozolomide, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. (clinicaltrials.gov)
  • Therapy is based on the location of the tumor, gene classification, and disease prognosis. (rochester.edu)
  • This is the most common treatment for any stage of colorectal cancer, but the type of surgery often depends on factors such as stage, size, and location of the tumor, and the overall health of the patient. (rochester.edu)
  • Both of these operations are used to remove early-stage cancers without opening the abdominal wall-but the type of surgery depends on the location of the tumor. (rochester.edu)
  • Interestingly, radiation at ∼20% of the dose necessary to induce local tumor control exerts similar tumor growth-inhibitory effects as the antiangiogenic drugs given at their maximum effective dose. (aacrjournals.org)
  • With respect to tumor angiogenesis, radiation further decreased microvessel density (CD31 count) and tumor cell proliferation (Ki-67 index) in all drug-treated groups. (aacrjournals.org)
  • Of note, the slowly growing PC3 tumor responded better to the antiangiogenic drug treatments than the faster-growing U87 tumor. (aacrjournals.org)
  • In addition to the beneficial effect of abrogating VEGF survival signaling when combined with radiation, we identified here a novel mechanism for the tumor escape from radiation damage. (aacrjournals.org)
  • A relative low radiation dose markedly enhances local antitumor effects of combined VEGF and PDGF signaling inhibition, suggesting a promising combination regimen for local tumor treatment with radiotherapy remaining an essential element. (aacrjournals.org)
  • The present article investigates the therapeutic potential of dual VEGF and PDGF RTKI in combination with radiotherapy as the present mainstay of nonsurgical local tumor therapy in vitro and in vivo . (aacrjournals.org)
  • As a consequence, investigations on hypoxia, including its causes and consequences for the cancer patient and its susceptibility to therapeutic manipulation, dominated research on tumor metabolism and microenvironment for many years. (aacrjournals.org)
  • However, findings concerning overexpression of glycolysis-related genes in 70% of all human cancers worldwide ( 2 ) and the exploitation of increased glucose uptake of cancer cells for tumor diagnostics by positron emission tomography with 18 F-fluorodeoxyglucose contributed to the topic once again experiencing a renaissance. (aacrjournals.org)
  • therapeutic
  • Drug repositioning, also named "drug repurposing or drug recycling," is a promising approach to overcome hurdles in discovering and developing new drugs via identification of the new therapeutic applications of known drugs. (frontiersin.org)
  • There is one more very important clinical application of these findings," Antoch said, "as they provide a rationale for developing drugs that can enhance the therapeutic index through the modulation of the circadian clock. (innovations-report.com)
  • novel
  • In the last 10 years the introduction of novel therapies, such as thalidomide, lenalidomide and bortezomib have further improved overall survival. (knowcancer.com)
  • Biology
  • you want to study the molecular pathology, biology and therapeutics of cancer at an advanced level and develop a dynamic career in biological research or continue with further postgraduate study. (le.ac.uk)
  • The determination of lactate should enter further clinical trials to confirm its relevance in cancer biology. (aacrjournals.org)
  • Antoch further extended these original findings after she moved to Cleveland and established her research program in the Department of Cancer Biology at the Cleveland Clinic Foundation. (innovations-report.com)
  • pancreatic cancer
  • Doctors use a number of different imaging tests to screen for pancreatic cancer. (bidmc.org)
  • CT Scan - Rapid multidetector computed tomography (CT) with three-dimensional imaging is one of the best ways to diagnose pancreatic cancer and determine its stage (how widespread it is). (bidmc.org)
  • A CT scan also can detect liver metastases, where pancreatic cancer is likely to spread. (bidmc.org)
  • ERCP and EUS can help diagnose pancreatic cancer at a very early stage. (bidmc.org)
  • Pancreatic cancer is one of the less common but deadliest cancers. (news-medical.net)
  • glioblastoma
  • Here, we analyze the combined VEGF (SU5416) and PDGF (SU6668) receptor tyrosine kinase inhibition with irradiation in human endothelium (HUVEC), prostate cancer (PC3), and glioblastoma (U87) in vitro and in vivo . (aacrjournals.org)
  • lymph nodes
  • A doctor removes the cancer and some of the surrounding healthy tissue and nearby lymph nodes, called a partial colectomy. (rochester.edu)
  • Cancer that has spread through the lining of the bladder and invades the muscle wall of the bladder or has spread to nearby organs and lymph nodes is called invasive bladder cancer. (cigna.com)
  • occurs
  • Juvenile myelomonocytic leukemia (JMML) is a rare childhood cancer that occurs more often in children around the age of 2 years and is more common in boys. (cancer.gov)
  • One of the most common cancers, lung cancer usually occurs when a cancer-causing agent, or carcinogen, triggers the growth of abnormal cells in the lung. (drugs.com)
  • occur
  • Anaplastic thyroid cancer tends to occur most often among women and accounts for about 2 percent of thyroid cancer cases. (orlive.com)
  • chemotherapeutic
  • Material and Methods: Human lung cancer cell line (NCI-H520) and various chemotherapeutic agents (paclitaxel, docetaxel, gemcitabine, and cisplatin) were used in this study. (aacrjournals.org)
  • Results: Among the various combinations of chemotherapeutic agents and radiation doses, concurrent chemoradiation therapy (CCRT) led to the highest rate of apoptosis and synergism. (aacrjournals.org)
  • certain
  • Animal studies have shown that CoQ10 helps the immune system work better and makes the body better able to resist certain infections and types of cancer (see Question 5 ). (cancer.gov)
  • Animal studies found that CoQ10 boosts the immune system and helps the body fight certain infections and types of cancer. (cancer.gov)
  • Cancer Fatigue -A certain type of fatigue associated with the cancer experience that has physical, social, and psychological impact. (mywhatever.com)
  • Having certain changes in the genes that are linked to bladder cancer. (cigna.com)
  • Research
  • Thank you for sharing this Cancer Research article. (aacrjournals.org)
  • Message Body (Your Name) thought you would be interested in this article in Cancer Research. (aacrjournals.org)
  • As well as developing your understanding of the processes and techniques used in cancer research, you will learn how to critically analyse research data and research papers and how to communicate complex scientific concepts and processes. (le.ac.uk)
  • Preclinical
  • Preclinical results in the NCI60 cancer cell line panel show that HIV protease inhibitors such as nelfinavir exhibit a wide spectrum of antitumor activity. (knowcancer.com)
  • cells
  • The drug valproic acid, currently approved for treating seizures, has been shown in laboratory tests to increase the radiosensitivity of glioma cells. (clinicaltrials.gov)
  • A predictive prognostic factor that has gained significant interest in association with breast cancer is the presence of cancer stem cells (CSCs). (spandidos-publications.com)
  • Lymphomas are cancers of the lymphoid cells in the body. (news-medical.net)
  • 1 . A method for treating disease, comprising (a) determining the location and number of cells characteristic of the disease according to claim 2 , and (b) applying a therapy to the patient. (google.de)
  • b4) treating the patient such that the inhibitor is overcome and drug acts on the cells characteristic of the disease. (google.de)
  • They are specialized phagocytic cells that attack foreign substances, infectious microbes and cancer cells through destruction and ingestion. (or.jp)
  • Radiofrequency ablation can be used to kill cancer cells with tiny electrodes. (rochester.edu)
  • We found that radiation induced up-regulation of all four isoforms of PDGF (A-D) in endothelial cells supporting adjacent smooth muscle cells resulting in a prosurvival effect of radiation. (aacrjournals.org)
  • Increased glucose uptake and accumulation of lactate, even under normoxic conditions (i.e., aerobic glycolysis or the Warburg Effect), is a common feature of cancer cells. (aacrjournals.org)
  • Radiation therapy involves the use of high-energy x-rays to kill cancer cells. (texasoncology.com)
  • Chemotherapy has the ability to kill cancer cells directly and make radiation therapy more effective in killing cancer cells. (texasoncology.com)
  • The body uses it for cell growth and to protect cells from damage that could lead to cancer (see Question 1 ). (cancer.gov)
  • By protecting cells against free radicals, antioxidants help protect the body against cancer. (cancer.gov)
  • Also, studies suggest that CoQ10 analogs ( drugs that are similar to CoQ10) may prevent the growth of cancer cells directly. (cancer.gov)
  • Skin cancer cells from a mouse show how cells attach at contact points, ZEISS Microscopy. (beckleyfoundation.org)
  • Therapy with natural chemicals to kill or regulate growth of cancer cells. (mywhatever.com)
  • This means cancer cells had started to spread before surgery, but they couldn't yet be detected. (drugs.com)
  • Bladder cancer is a disease in which malignant (cancer) cells form in the tissues of the bladder. (cigna.com)
  • There are three types of bladder cancer that begin in cells in the lining of the bladder. (cigna.com)
  • Transitional cell carcinoma: Cancer that begins in cells in the innermost tissue layer of the bladder. (cigna.com)
  • Most bladder cancers begin in the transitional cells. (cigna.com)
  • risk
  • Smoking cigarettes is by far the leading risk factor for lung cancer. (drugs.com)
  • Nonsmokers who inhale fumes from cigarette, cigar, and pipe smoking have an increased risk of lung cancer. (drugs.com)
  • People exposed to asbestos on the job (miners, construction workers, shipyard workers, and some auto mechanics) have a higher-than-normal risk of lung cancer. (drugs.com)
  • People who live or work in buildings with asbestos-containing materials that are deteriorating also have an increased risk of lung cancer. (drugs.com)
  • Asbestos exposure also increases the risk of developing mesothelioma , a relatively rare and usually fatal cancer. (drugs.com)
  • Hysterectomy with bilateral salpingo-oophorectomy (surgical removal of the uterus with removal of the fallopian tubes and ovaries on both sides) may be recommended for such high-risk women who no longer desire to get pregnant, to eliminate the chance of future cancer in these organs. (healthhype.com)
  • Smoking can affect the risk of bladder cancer. (cigna.com)
  • Talk to your doctor if you think you may be at risk for bladder cancer. (cigna.com)
  • Older age is a risk factor for most cancers. (cigna.com)
  • breast cancer
  • While breast cancer is the biggest and most publicized cancer threat American women face, it is not the only female-specific cancer. (energytimes.com)
  • A previous study revealed a significant difference in distant disease-free survival following IBTR depending on the subtype of breast cancer tissues present, as determined by immunohistochemical staining ( 6 ). (spandidos-publications.com)
  • Aldehyde dehydrogenase 1 (ALDH1) is a marker of CSCs ( 9 ) that may be easily evaluated in primary breast cancer tissues and is a potentially useful prognostic factor. (spandidos-publications.com)