- Chemotherapy , in its most general sense, refers to treatment of disease by chemicals that kill cells, specifically those of micro-organisms or cancer . (wikidoc.org)
- The first drug used for cancer chemotherapy, however, dates back to the early 20th century, though it was not originally intended for that purpose. (wikidoc.org)
- The targeted-therapy revolution has arrived, but the principles and limitations of chemotherapy discovered by the early researchers still apply. (wikidoc.org)
- These drugs have been used to prevent rejection of transplants and these are used as chemotherapy for cancers. (aao.org)
- Resistance to chemotherapy is when the cancer cells do not respond to the drugs. (savedelicious.com)
- a partial or complete loss of hair that may result from radiation therapy to the head, chemotherapy, skin disease, drug therapy, and natural causes. (thewomenofhope.org)
- Chemotherapy (often abbreviated to chemo and sometimes CTX or CTx ) is a type of cancer treatment that uses one or more anti-cancer drugs (chemotherapeutic agents or alkylating agents) as part of a standardized chemotherapy regimen. (worldsbest.rehab)
- Chemotherapy is one of the major categories of the medical discipline specifically devoted to pharmacotherapy for cancer, which is called medical oncology . (worldsbest.rehab)
- Importantly, the use of drugs (whether chemotherapy, hormonal therapy or targeted therapy) constitutes systemic therapy for cancer in that they are introduced into the blood stream and are therefore in principle able to address cancer at any anatomic location in the body. (worldsbest.rehab)
- The efficiency of chemotherapy depends on the type of cancer and the stage. (worldsbest.rehab)
- Cancer Chemotherapy - Lecture Outline 1. (present5.com)
- Targets for cancer chemotherapy 2. (present5.com)
- This variability together with the cellular heterogeneity are complications for cancer chemotherapy. (present5.com)
- Unlike microbial chemotherapy in which there are marked differences in chemistry from the host cells, the cancer cell provides relatively limited changes from the normal cells and does not offer clear targets for chemotherapeutic attack. (present5.com)
- Inhibition of Growth Experimental cancer chemotherapy has been largely directed at the inhibition of cellular proliferation with little attention being directed to more difficult models which would detect effects on the invasive and metastatic potential of cancer cells. (present5.com)
- Inhibition of Growth Cancer chemotherapy has often been seen as a last resort after surgery and irradiation have failed but there has been growing use of adjuvant chemotherapy in combined modality treatments. (present5.com)
- In contrast to microbial chemotherapy, there has been much greater emphasis on combination chemotherapy against cancer. (present5.com)
- The objectives in combination chemotherapy have been to limit the toxicity of individual agents and to evade drug resistance by exposing the cancer cell to drugs with different modes of action simultaneously. (present5.com)
- The remainder of this review will focus on the different chemotherapeutic agents currently being used for the treatment of cancer and their mechanism of action. (savedelicious.com)
- Traditional chemotherapeutic agents are cytotoxic by means of interfering with cell division (mitosis) but cancer cells vary widely in their susceptibility to these agents. (worldsbest.rehab)
- Toxicity of Anticancer Drugs The therapeutic index for cancer chemotherapeutic agents is usually low and the cells of the bone marrow and the gastrointestinal tract are usually the most sensitive normal cells. (present5.com)
- Cancer is the uncontrolled growth of cells coupled with malignant behavior: invasion and metastasis . (wikidoc.org)
- Together, these data indicate that SHIP2 expression contributes to the malignant potential of colorectal cancer, providing a possible target in the fight against this devastating disease. (oncotarget.com)
- and MELANOMA and non-melanoma skin cancers of the head and neck. (lookformedical.com)
- The overall effectiveness ranges from being curative for some cancers, such as some leukemias, to being ineffective, such as in some brain tumors, to being needless in others, like most non-melanoma skin cancers. (worldsbest.rehab)
- Methotrexate-induced lung disease, including acute or chronic interstitial pneumonitis, is a potentially dangerous lesion, which may occur acutely at any time during therapy and has been reported at low doses. (nih.gov)
- Cancer is thought to be caused by the interaction between genetic susceptibility and environmental toxins. (wikidoc.org)
- The development of therapies with specific molecular or genetic targets, which inhibit growth-promoting signals from classic endocrine hormones (primarily estrogens for breast cancer and androgens for prostate cancer) are now called hormonal therapies. (worldsbest.rehab)
- Fluorouracil interferes with genetic material (DNA and RNA), which is necessary for the growth and reproduction of cancer cells. (rxhealthmed.ca)
- As well as interfering with the genetic material DNA and RNA of cancer cells, fluorouracil can interfere with some of your normal cells. (rxhealthmed.ca)
- The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
- Colorectal cancer (CRC) is the second most common cause of cancer-related death, encouraging the search for novel therapeutic targets affecting tumor cell proliferation and migration. (oncotarget.com)
- However, cancer cells can become multidrug resistant, a phenomenon due to cells expressing mechanisms that cause simultaneous resistance to many different, structurally and functionally, unrelated drugs [6]. (savedelicious.com)
- Systemic therapy is often used in conjunction with other modalities that constitute local therapy (i.e., treatments whose efficacy is confined to the anatomic area where they are applied) for cancer such as radiation therapy, surgery or hyperthermia therapy. (worldsbest.rehab)
- In popular usage, it usually refers to antineoplastic drugs used to treat cancer or the combination of these drugs into a standardized treatment regimen . (wikidoc.org)
- As a result, many other drugs have been developed to treat cancer, and drug development since then has exploded into a multi-billion dollar industry. (wikidoc.org)
- Most cancer chemotherapeutic drugs affect only one characteristic aspect, which is uncontrolled proliferation [3]. (savedelicious.com)
- Increased drug efflux, via these transporters, lowers intracellular drug concentration, allowing cancer cells to escape the toxic effects of the drugs. (savedelicious.com)
- Drugs used in the treatment of cancer are summarised in table 2. (savedelicious.com)
- The recommended dose of fluorouracil varies widely according to the specific condition being treated, the response to therapy, and the other medications being used. (rxhealthmed.ca)
- Further evidence suggests that a given dose of a cancer chemotherapeutic agent causes the death of a constant proportion of cancer cells (first order kinetics). (present5.com)
- We found that SHIP2 and INPPL1 expression is increased in colorectal cancer tissue in comparison to adjacent normal tissue, and this is correlated with decreased patient survival. (oncotarget.com)
- Moreover, SHIP2 is more active in colorectal cancer tissue, suggesting that SHIP2 can induce oncogenesis in colonic epithelial cells. (oncotarget.com)
- It was reasoned that an agent that damaged the rapidly growing white blood cells might have a similar effect on cancer. (wikidoc.org)
- Therefore, in the 1940s, several patients with advanced lymphomas (cancers of certain white blood cells) were given the drug by vein, rather than by breathing the irritating gas. (wikidoc.org)
- Introduction Cancer may be considered to be an unregulated proliferation of cells of which the cardinal features in addition to growth are invasion and metastasis. (present5.com)
- Since there is generally negligible immune response to cancer cells it has been argued that there should be complete elimination of neoplastic cells for a cure to be achieved. (present5.com)
- For this reason, the elimination of all cancer cells is more likely to be achieved when the tumor burden is small. (present5.com)
- Therapeutic targeting of the hallmarks of cancer. (present5.com)
- Furthermore, in vitro experiments performed on colorectal cancer cell lines shows an oncogenic role for SHIP2, by enhancing chemoresistance, cell migration, and cell invasion. (oncotarget.com)
- It represents a large group of epithelial lung malignancies which can be divided into two clinical groups: SMALL CELL LUNG CANCER and NON-SMALL-CELL LUNG CARCINOMA . (lookformedical.com)
- There is experimental evidence that a single cancer cell may be sufficient to give rise to a fatal response after proliferation. (present5.com)
- Aberrant activity of kinases is observed in many forms of cancer and as phosphatases counteract such "oncogenic" kinases, it is generally assumed that phosphatases function as tumor suppressors. (oncotarget.com)
- an organization that supports research, educational materials and programs, and offers many other services to cancer patients and their families. (thewomenofhope.org)
- Please consider making a contribution to support our efforts to educate, promote awareness, and provide hope for families currently coping with the effects of breast cancer. (thewomenofhope.org)
- The following are health and medical definitions of terms that may appear in reference to breast cancer. (thewomenofhope.org)
- male sex hormone which may be used to treat recurrent breast cancer by opposing the activity of estrogen. (thewomenofhope.org)
- In referring to a growth, abnormal may mean that it is cancerous or premalignant (likely to become cancer). (thewomenofhope.org)
- By contrast, other inhibitions of growth-signals like those associated with receptor tyrosine kinases are referred to as targeted therapy. (worldsbest.rehab)
- Antibiotics may be needed along with the cancer treatment to prevent or treat infections. (thewomenofhope.org)
- Cancer is one of the major causes of death in the developed world and statistics show that one in three people will be diagnosed with cancer during their lifetime [1]. (savedelicious.com)
- Diarrhea and ulcerative stomatitis require interruption of therapy: otherwise, hemorrhagic enteritis and death from intestinal perforation may occur. (nih.gov)
- That experience led researchers to look for other substances that might have similar effects against cancer. (wikidoc.org)
- stage of cancer in which the disease has spread from the primary site to other parts of the body. (thewomenofhope.org)
- long-term dependence on steroid therapy, if more than 5-10mg/day of prednisolone is required to keep the disease in control- steroid-sparing IMT is indicated. (aao.org)
- Usage of L-lysine HCl independently as well as in compounded form has been reported for nephroprotection when radioactive therapy is conducted especially against cancer. (empowerpharmacy.com)