Cancer stem cells cell biology clone cells. Medical search. Frequent questions

His demonstration that the expression of four master regulatory genes was sufficient to cause the reprogramming of adult cells has opened up many possibilities for human stem cell therapies. (brandeis.edu)
Thus, a better understanding of the in vivo mechanisms that regulate CSCs is essential for the development of more effective anti-cancer therapies. (nature.com)
It is currently accepted by many that failure to eradicate CSC populations severely limits the ultimate effectiveness of many current cancer therapies. (bio-connect.nl)
We are also applying this approach to analyse patients receiving novel targeted therapies in order to better understand mechanisms of resistance to molecularly targeted therapy in stem cell populations and pathways of transformation to more aggressive forms of disease. (ox.ac.uk)
People who undertake medical tourism for stem cell therapies are demonstrating their own risk preferences: balancing the plausible expected benefits based on what is presently known of the science and the outcomes (in the absence of rigorous trials) against the cost and estimated risk. (fightaging.org)
For stem cell treatments perhaps the largest inherent risk for early stage therapies is that of cancer resulting from the activities of transplanted cells. (fightaging.org)
The world of cancer treatments is, meanwhile, changing profoundly, gearing up for a new generation of therapies that will displace chemotherapy and radiotherapy . (fightaging.org)
Improvements in cancer treatment - leading to the introduction of robust therapies that can clear most common forms of cancer quickly and without accompanying illness - will, I think, go hand in hand with a far greater demand for and use of very aggressive stem cell treatments. (fightaging.org)
Similarly, why boost regeneration and tissue maintenance via stem cell therapies only in the sick and the wounded? (fightaging.org)
That makes sense if there is a significant risk associated with treatment, but in a world in which cancer is merely troublesome, why not make stem cell therapies a part of general health maintenance? (fightaging.org)
These cells have been sought after as potential therapies for diseases ranging from heart disease to Parkinson's to cancer. (news-medical.net)
But SCNT can also be used to clone human cells for transplant or other therapies. (news-medical.net)
What is the main risk factor when using embryonic stem cells in medical therapies? (goodmancoaching.nl)
The review highlights the discovery of oncogenes and suppressor tumor genes, underlining the crucial role of these achievements in cancer diagnosis and therapies. (jcancer.org)

This also might have explained why cloning is inefficient: only 1-3% of cloned embryos eventually develop into an adult clone. (rupress.org)
Three days ago the science journal Nature reported that mouse tissue cells in the US and Japan were turned into embryonic-type stem cells without the use of eggs or embryos. (freerepublic.com)
Despite the many advances in adult stem cell research, the federal and Victorian parliaments have already passed bad legislation legitimising the destruction of human embryos. (freerepublic.com)
One aspect to this project will be to source oocytes, or immature egg cells to generate SCNT embryos from which embryonic stem cells are harvested. (medicalxpress.com)
In humans, a major roadblock in achieving successful SCNT leading to embryonic stem cells has been the fact that human SCNT embryos fail to progress beyond the eight-cell stage. (news-medical.net)
They derived several human embryonic stem cell lines from these cloned embryos whose DNA was an exact match to the adult cell that donated the DNA. (news-medical.net)
Using embryos in stem cell medicine? (goodmancoaching.nl)
Is it ethical to take stem cells from embryos? (goodmancoaching.nl)
Can IVF embryos be used for stem cell research? (goodmancoaching.nl)
These tiny embryos can be used for research , and scientists used them to figure out how to grow pluripotent cells in the lab (Figure 2). (goodmancoaching.nl)
How many embryos are destroyed each year for stem cell research? (goodmancoaching.nl)
However, human embryonic stem cell (hESC) research is ethically and politically controversial because it involves the destruction of human embryos . (goodmancoaching.nl)
Somatic cell nuclear transfer is immoral as it involves creating embryos only to destroy them. (goodmancoaching.nl)

Receptor tyrosine kinases (RTKs) play fundamental tasks in varied cell functions including proliferation differentiation survival migration and rate of metabolism (16). (exposed-skin-care.net)
Drs. John B. Gurdon, Irving L. Weissman, and Shinya Yamanaka have been pioneers in studying stem cells and the reprogramming of highly differentiated adult cells into pluripotent cells capable of directing differentiation from a single cell to an adult animal. (brandeis.edu)
Transferring a terminally differentiated cell nucleus into an egg cell that has had its own nucleus removed wipes away the epigenetic marks of differentiation and allows the nucleus once again to code for any cell type. (rupress.org)
Despite resemblance to mesenchymal stem cells (MSCs) in terms of self-renew and tri-lineage differentiation, the ability of IMRCs to repair the meniscus and the underlying mechanism remains undetermined. (bvsalud.org)
The basal cells (BC) are the stem/progenitor cells of the SAE, responsible for the differentiation into intermediate cells and ciliated, club and mucous cells. (biomedcentral.com)
The resulting cell line (hSABCi-NS1.1) was characterized by RNAseq, TaqMan PCR, protein immunofluorescence, differentiation capacity on an air-liquid interface (ALI) culture, transepithelial electrical resistance (TEER), airway region-associated features and response to genetic modification with SPDEF. (biomedcentral.com)
The immortalized hSABCi-NS1.1 cell line has diverse differentiation capacities and retains SAE features, which will be useful for understanding the biology of SAE, the pathogenesis of SAE-related diseases, and testing new pharmacologic agents. (biomedcentral.com)
The topics covered include nuclear reprogramming, regulation of stem cell self-renewal and differentiation, the stem cell niche, and signaling and gene regulation in stem cells. (cshlpress.com)
Temporal multimodal single-cell profiling of native hematopoiesis illuminates altered differentiation trajectories with age. (lu.se)

Soluble Axl (sAxl) is present in cell-conditioned medium of CUDC-305 (DEBIO-0932 ) tumor cells growing in vivo and in vitro and in the sera of humans mice and rats (23 50 However the identities of the sAxl-generating protease(s) and the mechanism(s) that account for this process remain unknown. (exposed-skin-care.net)
CSCs display the slow-migratory, invadopod-rich phenotype that is the hallmark of disseminating tumor cells. (nature.com)
60% of circulating tumor cells. (nature.com)
however, restoration of CBY1 expression in tumor cells reduces BCSC and its enrichment, thus lnc408 plays an essential role in maintenance of BCSC stemness. (nature.com)
It is also expressed on mesenchymal stem cells, erythroid precursors, activated macrophages, pre-B cells, and some tumor cells and cell lines including U937 cells. (bdbiosciences.com)
It is the outcome of many factors, including the cross-talk between tumor cells within the tumor microenvironment and the acquisition and accumulation of genetic and epigenetic alterations in tumor cells. (molcells.org)
The regulation of the stem cell-like properties by several important signaling pathways have been found to endow the tumor cells with an increased level of tumorigenicity, chemoresistance, and metastatic ability. (molcells.org)
HCC heterogeneity is believed to be the outcome of combinatorial effects, including the acquisition of genetic and epigenetic alterations in tumor cells, the cross-talk of cells within the tumor microenvironment, as well as the existence of a cancer stem cell (CSC) subpopulation that has the ability to self-renew and differentiate. (molcells.org)

He makes knockout and transgenic mice to study the function of genes in bone development and cancer. (rupress.org)
He cloned, characterized the family of phosphoglycerate kinase (PGK) genes and pseudogenes. (madridge.org)
Characteristics of Clonal Hematopoiesis (CH) Mutations - a) We identified somatic mutations in known clonal hematopoiesis of indeterminate potential (CHIP) driver genes using peripheral blood mononuclear cells isolated from 14 astronauts who flew short space Shuttle missions lasting a median of 12 days between 1998-2001. (spaceref.com)
However, the frequency of the somatic mutations in the genes that the researchers assessed was less than two percent, the technical threshold for somatic mutations in hematopoietic stem cells to be considered clonal hematopoiesis of indeterminate potential (CHIP). (spaceref.com)
CD326 functions as a homotypic calcium-independent cell adhesion molecule and is believed to be involved in carcinogenesis by its ability to induce genes involved in cellular metabolism and proliferation. (biolegend.com)
Our scientists pursue every aspect of cancer research-from exploring the biology of genes and cells, to developing immune-based treatments, uncovering the causes of metastasis, and more. (mskcc.org)
Amongst the intestinal Wnt target genes (13), we found the Gpr49/Lgr5 gene to be unique in that it marks small cycling cells at crypt bottoms. (hubrecht.eu)
Two other Wnt target genes, RNF43 and ZNRF3, encode stem cell-specific E3 ligases that downregulate Wnt receptors in a negative feedback loop (35). (hubrecht.eu)
He and his colleagues, in collaboration with the Broad Institute of Harvard and MIT, analyzed some 17,000 blood samples, searching for mutations in nearly 200 genes known to be associated with blood cancers. (dana-farber.org)
They also discovered that these mutated genes coincided with the abnormal expansion of the blood cells that harbor them - a phenomenon known as clonal hematopoiesis (CH) . (dana-farber.org)
In animal studies conducted in collaboration with Peter Libby, MD, at Brigham and Women's Hospital, they showed that blood cells carrying one of the commonly mutated genes associated with CH can accelerate the onset of heart disease in mice. (dana-farber.org)
Screening for recurrently mutated genes in the mononuclear cell fraction revealed mutations in SF3B1 in 39 of 40 cases (97.5%), combined with TET2 and DNMT3A in 11 (28%) and 6 (15%) patients, respectively. (nih.gov)
Compared to the large airway cell line BCi-NS1.1, differentiated of hSABCi-NS1.1 cells on ALI were enriched with small airway epithelial genes, including surfactant protein genes, LTF and small airway development relevant transcription factors NKX2-1, GATA6, SOX9, HOPX, ID2 and ETV5. (biomedcentral.com)
Below is a non-exhaustive list of in-house infrastructures that are categorized into three overarching themes: bio-imaging, proteins, genes & cells and other resources. (lu.se)
Below you can see some examples of the infrastructure for research on genes and cells, available for researchers at Lund University. (lu.se)
In addition to infrastructures for bioimaging, protein and genes & cells, we also provide other resources e.g., databases, networks and specialized labs. (lu.se)
Inoculation with a high dose strains of LMP1 transgenic mice vide a powerful tool in mechanistic of EBV caused a B-cell lymphopro- were established that express LMP1 studies on the role of individual viral liferative disorder in these mice, under the control of the immunoglob- genes in cancer. (who.int)

The Haematopoietic Stem Cell Biology (HSCB) Laboratory is focused on understanding how the normal haematopoietic stem/progenitor hierarchy is disrupted during the development of myeloid malignancies. (ox.ac.uk)
The major focus of our research programme is to identify and genetically model leukaemic and pre-leukaemic stem cells in myeloid malignancies. (ox.ac.uk)
1. Development of genetically engineered models of myeloid malignancies in order to study the impact of specific driver mutation(s) on the establishment, evolution and propagation of leukaemic stem cells. (ox.ac.uk)
Our particular focus is to refine risk stratification of patients using these molecular markers and also to gain a better understanding of how germline mutations might disrupt stem/progenitor cell populations to promote the development of myeloid malignancies. (ox.ac.uk)
Single-cell transcriptomics uncovers distinct molecular signatures of stem cells in chronic myeloid leukemia. (ox.ac.uk)
All recurrent mutations identified in mononuclear cells could be tracked back to the phenotypically defined hematopoietic stem cell (HSC) compartment in all investigated patients and were also present in downstream myeloid and erythroid progenitor cells. (nih.gov)
Some persons with clonal hematopoiesis are at increased risk for the development of myeloid cancers such as acute myeloid leukemia or myelodysplastic syndromes, a risk that increases as the hematopoietic clone expands in size.16 Stopping this expansion may delay or avert leukemic progression, and therapeutic approaches to this end are being developed and tested. (cdc.gov)
POT1 mutation carriers had a range of benign and malignant neoplasms involving epithelial, mesenchymal, and neuronal tissues in addition to B- and T-cell lymphoma and myeloid cancers. (cdc.gov)

In mammary gland development, Notch-dependent heterotypic signaling between resident tissue macrophages and mammary stem cells supports survival and function of the normal mammary stem cell 20 . (nature.com)
Our goal is to identify and define the single normal and cancer stem cell of every human tissue in order to succeed in cancer and stem cell therapy, organ engineering, reconstructive and cosmetic surgery.The exact phenotype of CSC and their counterparts in normal mammary gland is not well characterized. (madridge.org)
He contributed to the emergence of the field of stem cell biology & tissue engineering. (madridge.org)
SSCs are adult-tissue stem cells in the mammalian testis that balance self renewing and differentiating fate decisions to give rise to and sustain the entire spermatogenic lineage. (utsa.edu)
The Organoid group, previously Clevers group, studies the molecular mechanisms of tissue development and cancer of various organs using organoids made from adult Lgr5 stem cells. (hubrecht.eu)
These cells represent the epithelial stem cells of the small intestine and colon (23), the hair follicle (24), the stomach (28) and many other tissue stem cell types. (hubrecht.eu)
This versatility allows embryonic stem cells to be used to regenerate or repair diseased tissue and organs . (goodmancoaching.nl)
8 Jun, 2007 04:13 pm Stem cells provide the starting material for the development and repair of every organ and tissue in the body and they are present in all stages of life. (scitizen.com)

The mutations identified in this study were characterized by the overrepresentation of blood cells derived from a single clone, a process called clonal hematopoiesis (CH). Such mutations are frequently caused by environmental factors, such as exposure to ultraviolet radiation or certain chemicals, and may be a result of cancer chemo- or radiotherapy. (spaceref.com)
We use this model to investigate clonal hematopoiesis, which is a significant risk factor for hematologic cancers. (uzh.ch)
In collaboration with Dr. Papapetrou from Mt. Sinai, André is using pre-identified primary samples with sub-clonal patterns of mutations to generate patient tailored induced pluripotent stem cell (iPSCs) lines. (mskcc.org)
Long-term clonal culturing of organoids from Lgr5 stem cells. (hubrecht.eu)
While in agreement with previous studies, little or no evidence for clonal ( SF3B1 mutation) involvement could be found in mature B cells, consistent involvement at the pro-B-cell progenitor stage was established, providing definitive evidence for SF3B1 mutations targeting lymphomyeloid HSCs and compatible with mutated SF3B1 negatively affecting lymphoid development. (nih.gov)

Retrieved on December 04, 2023 from https://www.news-medical.net/life-sciences/Cloning-Human-Cells.aspx. (news-medical.net)

It was thought that mammalian cells might be refractory to cloning. (rupress.org)
He cloned the pgk-2 gene, showing for the first time that gene duplication, by retroposition more than 100 million years ago, have been used as a mechanism for evolutionary diversification and that mammalian genomes are fluid creating new species. (madridge.org)
One cloning technology that has been developed for mammalian and human cells is somatic cell nuclear transfer (SCNT). (news-medical.net)
SCNT is a method of cloning mammalian cells that can be used to create personalized embryonic stem cells from an adult animal or human. (news-medical.net)

The Organizer cordially invites abstracts and full length research papers from all over the World to participate in the World Congress on "Stem Cell Research, Cancer Biology and Applied Biotechnology" (Biotech-2014) is the premier forum for the presentation of new advances and research results in the fields of theoretical, experimental, applied molecular biology, genetics, cell sciences, cancer biology, stem cell research and applied biotechnology. (iranconferences.ir)
Ginés introduced me to genetics, but I wanted a middle ground between molecular biology and genetics. (rupress.org)
Group II: Graduates of Biology, Molecular Biology and Genetics and Chemistry departments at the Faculty of Sciences. (etu.edu.tr)
A large body of new data from Mendelian genetics and epidemiology now provides an opportunity to reconsider paradigms related to the role of telomeres in human aging and cancer. (cdc.gov)
Genetics of human telomere biology disorders. (cdc.gov)

The image shows single cell RNA-sequencing analysis of haematopoietic stem/progenitor cells from a patient with a myeloproliferative neoplasm. (ox.ac.uk)
4. Characterisation of cell-extrinsic regulators of haematopoietic stem/progenitor cells, including bone marrow niche populations, and how they are disrupted during the development of myeloproliferative neoplasms and related conditions. (ox.ac.uk)
This process relies on the formation of a blastema, a pool of progenitor cells that is formed in response to amputation. (lu.se)

We predict the time taken for mutant clones to expand within a host, as well as chimerism levels that can be expected following transplantation therapy, and the probability that a preconditioned host is reconstituted by donor cells. (uzh.ch)
Clare's lab recently identified a population of progenitor/stem cells in mice that, on transplantation, is sufficient to generate a fully functional thymus. (eurostemcell.org)
These epithelial organoid cultures are genetically and phenotypically extremely stable, allowing transplantation of the cultured offspring of a single stem cell, as well as disease modeling by growing organoids directly from diseased patient tissues (32, 47, 53). (hubrecht.eu)
Second-line chemotherapy regimens vary, depending on whether hematopoietic stem cell transplantation (HSCT) is being considered. (medscape.com)
Reprogramming skin cells to blood stem cells could potentially provide an unlimited source of cells for transplantation to patients with blood disorders. (lu.se)
The essence of MDS is damage of In the current work we examined All our patients were of the high-risk colony-forming units [4], but the defect haematopoietic stem cells of high-risk group and none of them was eligible of the haematopoietic stem cells is not MDS cases for apoptotic and anti-apop- for stem cell transplantation. (who.int)

Gas6 is the product of growth arrest-specific gene 6 which was in the beginning cloned from serum-starved fibroblasts and shares about CUDC-305 (DEBIO-0932 ) 44% sequence identity and related website organization with protein S a negative regulator of blood coagulation (48). (exposed-skin-care.net)
He designed and constructed The PGK1-Neo Shuttle which is being used around the world for gene therapy, to engineer, from embryonic stem cells, transgenic and knockout animals to understand the causes and mechanisms of all human diseases and find cures. (madridge.org)
We were the first to link Wnt signaling with adult stem cell biology, when we showed that TCF4 gene disruption leads to the abolition of crypts of the small intestine (8), and that TCF1 gene knockout severely disables the stem cell compartment of the thymus (2). (hubrecht.eu)
The Tcf4-driven target gene program in colorectal cancer cells is the malignant counterpart of a physiological gene program in selfrenewing crypts (13, 14). (hubrecht.eu)
The Wnt target gene encoding the transcription factor Achaete scute-like 2 controls intestinal stem cell state (26). (hubrecht.eu)
Amazingly, the first human cancer gene was cloned only thirty years ago. (jcancer.org)
Cloning and characterization of a serine/threonine protein phosphatase2A-encoding gene IbPP2A1 from Ipomoea batatas (L.) Lam. (tubitak.gov.tr)
Our data have provided evidence for a comparable prediction of clinical outcome in CMF-treated breast cancer patients using conventional clinical variables and gene expression based markers. (lu.se)
Our findings are paving the way for the development of a gene therapy for cancer where the three molecules are delivered directly into tumors in patients eliciting a response independently of the tumor type. (lu.se)
2. Nuclear transfer is a technique used to duplicate genetic material by creating an embryo through the transfer and fusion of a diploid cell in an enucleated female oocyte.2 Cloning has a broader meaning than nuclear transfer as it also involves gene replication and natural or induced embryo splitting (see Annex 1). (who.int)

West organized the first collaborative effort to isolate human pluripotent (embryonic) stem cells for the purpose of manufacturing products in regenerative medicine in collaboration with James Thomson at the University of Wisconsin at Madison, John Gearhart at Johns Hopkins School of Medicine, and Roger Pedersen at the University of California, San Francisco. (wikipedia.org)
The awards will be given March 26 in a private reception, following a free public symposium entitled "Generation of Pluripotent Stem Cells. (brandeis.edu)
Scientists from the Monash Institute of Medical Research (MIMR) and colleagues from New South Wales will compare two different methods of creating patient-specific stem cells: somatic cell nuclear transfer (SCNT) and induced pluripotent stem cells (iPS). (medicalxpress.com)
The resulting cells were pluripotent and could be differentiated into insulin-producing beta cells to restore the function of the pancreas in the donor. (news-medical.net)
These are pluripotent (ploo-RIP-uh-tunt) stem cells, meaning they can divide into more stem cells or can become any type of cell in the body. (goodmancoaching.nl)

Things like periodic infusions of massive numbers of immune cells cloned from a patient's own cells, done not just for people with medical conditions, but for the healthy as a beneficial preventative measure. (fightaging.org)
Partner with us to treat your patient's cancer. (mskcc.org)
Driven by the challenges his patients face when fighting cancer - specifically addressing the vast heterogeneity in treatment response by identifying the optimal treatment to pair with each patient's unique biology - he leads a laboratory focused on developing integrated circuits (or "computer chips") for in vivo cancer sensing. (nih.gov)

West has authored and co-edited books on topics including animal cloning, aging, biogerontology, stem cells, stem cell biology, and regenerative medicine. (wikipedia.org)
Dr. Irving L. Weissman is professor of pathology and developmental biology at the Stanford University School of Medicine , where he is director of the Institute of Stem Cell Biology and Regenerative Medicine. (brandeis.edu)
These are the sort of shifts in the cost-benefit picture of regenerative medicine that will emerge over the next couple of decades, driven by a growing ability to control the undesirable aspects of cellular biology, such as cancer. (fightaging.org)
The intricate molecular mechanisms involved in the regenerative process of the normal intestine and the identity of putative somatic intestinal stem cells have become clear. (mdpi.com)
We're a partnership of more than 400 stem cell and regenerative medicine labs across Europe, connected via research centres, consortia, networks and hubs. (eurostemcell.org)
Paolo De Coppi is a Consultant Paediatric Surgeon at Great Ormond Street Hospital (GOSH), and Reader and Head of Stem Cells and Regenerative Medicine at the UCL Institute of Child Health in London. (eurostemcell.org)

In 1962 he made the stunning observation that it was possible to take a differentiated adult cell from a frog and to re-set its genetic program so that the reprogrammed nucleus could be implanted in an enucleated egg and direct the development of tadpoles. (brandeis.edu)
Scientists are also working on ways to develop stem cells from other cells, using genetic "reprogramming" techniques. (goodmancoaching.nl)
While many scientists were studying genetic markers of cancer in people already diagnosed with the condition, the team had a very different question: Do the genetic mutations that drive the growth of leukemia and other blood cancers lurk in the bodies of people without cancer? (dana-farber.org)
Through the cloning of Dolly, we learned that the cell nucleus contains all the genetic information needed for the cell to develop into any type of cell. (lu.se)
A clone is an organism that is a genetic copy of an existing one. (who.int)

That same year, he joined the laboratory of Samuel Goldstein, a molecular gerontologist at the University of Arkansas at Little Rock, and began to research the molecular biology of aging. (wikipedia.org)
Prior to joining BioTime, West was chairman of the board, chief scientific officer and CEO of Advanced Cell Technology (ACT), another biotechnology company focused on stem cell research. (wikipedia.org)
In their telomerase research, West and colleagues at Geron cloned the RNA component of telomerase and collaborated with Thomas Cech (winner of 1989 Nobel Prize in Chemistry), with whom they cloned the catalytic component of the enzyme telomerase, and sponsored collaborative research in the laboratory of Carol Greider, then at Cold Spring Harbor Laboratory. (wikipedia.org)
A decade of stem-cell research. (wikipedia.org)
The 2009 Rosenstiel Award for Distinguished Work in Basic Medical Science will be awarded to three pioneers in stem cell research. (brandeis.edu)
MPs may have voted for stem cell research, but it is unethical and a scientific dead end, writes Cardinal George Pell. (freerepublic.com)
Research institutes around St Vincent's Hospital make up one of the largest bio-medical research complexes in the southern hemisphere. (freerepublic.com)
Professor Alan Mackay Sim's Queensland team of scientists working on nasal stem cell research for spinal cord injuries and Professor Pritinder Kaur's team at Peter MacCallum Cancer Centre working on using adult stem cells for burns victims are both supported by grants from the Sydney archdiocese. (freerepublic.com)
Victoria and New South Wales have put aside their competitive interstate rivalry to collaborate on a stem cell research project, as announced by Innovation Minister Gavin Jennings and NSW Minister for Science and Medical Research, Verity Firth, today. (medicalxpress.com)
Mr Jennings said changes to the Victorian Infertility Treatment Act and the NSW Human Cloning and Other Prohibited Practices Act have opened up new opportunities for stem cell research in Australia. (medicalxpress.com)
Australia is already a global leader in overall stem cell research and this new and clear regulatory framework gives us an opportunity to extend our leadership into SCNT which could transform how we treat diabetes, heart diseases and Parkinson's," Mr Jennings said. (medicalxpress.com)
Our highly-specialized educational programs shape leaders to be at the forefront of cancer care and research. (mskcc.org)
André Deslauriers is a research scholar at the Memorial Sloan Kettering Cancer Center in the Department of Epidemiology and Biostatistics under the supervision of Dr. Elli Papaemmanuil. (mskcc.org)
EuroStemCell has key partnerships with European Union-funded stem cell research consortia who provide significant contribution to the project financially and scientifically. (eurostemcell.org)
He co-ordinates the EU Horizon2020 funded stem cell research consortium - INTENS which aims to aims to make a functional reconstructed bowel for people with Short Bowel Syndrome. (eurostemcell.org)
He has been leader of a research group at the Max-Delbrück-Center for Molecular Medicine in Berlin until 2011 focusing his research on signal transduction mechanisms in human and murine embryonic stem cells. (eurostemcell.org)
However, human embryonic stem cell (HESC) research is unethical since it results in the destruction of human life for research purposes . (goodmancoaching.nl)
Stem cell research is legal in the United States , however, there are restrictions on its funding and use. (goodmancoaching.nl)
Opponents argue that the research is unethical, because deriving the stem cells destroys the blastocyst, an unimplanted human embryo at the sixth to eighth day of development . (goodmancoaching.nl)
Stem cell research would deviate efforts from other health strategies. (goodmancoaching.nl)
In both cases, the embryo is ultimately destroyed, which opponents of embryonic stem cell research argue is immoral. (goodmancoaching.nl)
He did a four-month internship in Leukemia stem cells research group, at Josep Carreras Leukaemia Research Institute. (isglobal.org)
His master's thesis was completed in Cancer and aging research group, at IDIBELL, under the supervision of Dra. (isglobal.org)
This, and other extraordinary scientific goals achieved by molecular cancer research in the last 30 years, seems to suggest that definitive answers and solutions to this severe disease have been finally found. (jcancer.org)
Old theories and achievements have provided the pillars of cancer understanding, in laying the basis of 'modern era' cancer research, are discussed. (jcancer.org)
This knowledge, previously unproved, is a reality in today's research and plays a vital role in the understanding of cancer. (jcancer.org)
Nowadays, even though scientific research moves ahead rapidly, cancer still needs solid and reliable solutions. (jcancer.org)
Considering the past, and reviewing the milestones of every scientific finding could help in molding future experimental approaches in cancer research. (jcancer.org)
8 Feb, 2008 06:09 pm Six years ago, biomedical engineer Michael King was exploring the strange rolling motion of white blood cells when his research took a radical turn. (scitizen.com)
27 Nov, 2007 10:41 am Tony Maciulis talks with Dr. Jon LaPook about a breakthrough in stem cell research. (scitizen.com)
21 Nov, 2007 10:54 am A huge advancement in stem cell research--and a stake in the heart of human cloning--was announced yesterday. (scitizen.com)
6 Sep, 2007 12:57 pm British authorities decided yesterday to permit research that uses animal eggs to create human stem cells because of the limited supply of human eggs. (scitizen.com)
25 Jun, 2007 04:43 pm On June 7, the House of Representatives voted 247-176 to pass a bill (S 5) that would allow federal funding for research using stem cells derived from. (scitizen.com)
Based on presentations by world-renowned investigators at the 73rd annual Cold Spring Harbor Symposium on Quantitative Biology, this volume reviews the latest advances in research on the control and regulation of stem cells. (cshlpress.com)
Studies of embryonic stem cells and adult stem cells are covered, along with research shedding light on the roles of these cells in regeneration and cancer. (cshlpress.com)
Pereira's research also involves reprogramming skin cells into dendritic cells, which are the sentinels of the immune system. (lu.se)
5. In 2001, France and Germany requested the United Nations General Assembly to develop international conventions on human reproductive cloning, therapeutic cloning and research on stem cells. (who.int)
The 2005 World Health Organization-European Organization for Research and Treatment of Cancer (WHO-EORTC) classification of CTCLs is divided into those with indolent clinical behavior and those with aggressive subtypes. (medscape.com)

Our protocols help understand breast cancer, cancers heterogeneity, drug resistance, towards eradicating the roots of all cancers. (madridge.org)
This is crucial in order to unravel the intratumoural heterogeneity within any phenotypically defined malignant stem cell population. (ox.ac.uk)
A leading contributing factor to metastasis and treatment resistance is the heterogeneity and plasticity of the cells within tumors 6 . (nature.com)

Cloning of human cells is a technology that holds the potential to cure many diseases and provide a source of exactly matched transplant tissues and organs. (news-medical.net)
In mammals, physiological Wnt signaling is intimately involved with the biology of adult stem cells and self-renewing tissues (18,19). (hubrecht.eu)
MSC are known to home to specific tissues e.g. the bone marrow, muscle, or spleen, particularly when the tissues are damaged or under pathological conditions such as ischemia or cancer [32,81,82,84,85]. (goodmancoaching.nl)
27 Jun, 2007 06:08 pm Stem cells have the potential to become all the cells and tissues in the human body. (scitizen.com)
Inspired from developmental processes, human mesenchymal cell lines can be programmed to form cartilage, bone and bone marrow tissues in vitro and in vivo. (lu.se)
Our facilities provide the opportunity to study protein structure, molecular probes and drug design, system biology and molecular interactions in cells and tissues. (lu.se)
genic models are inadequate for number of activated CD8-positive T LMP1 was strongly expressed in the understanding the cancer etiology in cells increased considerably in the lymphoma tissues but was hardly the context of natural viral infection. (who.int)

Moreover, CD44 is reported as cell surface marker for cancer stem cells (CSCs) derived from solid tumors including breast, prostate, colon, head and neck and pancreatic cancer. (bio-connect.nl)
Cancer has been in existence on Earth even before the appearance of man, as evidenced by paleontological findings of tumors in animals ( 1 , 2 ). (jcancer.org)
In cancer patients dendritic cells may become dysfunctional or excluded from tumors. (lu.se)
The reprogrammed cancer cells thereby lose their ability to become tumors, and instead activate the immune system to respond to mutated proteins in the tumor. (lu.se)
Resolving the Pathogenesis of Anaplastic Wilms Tumors through Spatial Mapping of Cancer Cell Evolution. (lu.se)

He was the first to appreciate the therapeutic potential of stem cell therapy and has pioneered its development. (brandeis.edu)
The therapeutic potential of cloned human cells has been demonstrated by another study using human oocytes to reprogram adult cells of a type 1 diabetic. (news-medical.net)
Sinevici N, Harte N, O'Grady I, Xie Y, Min S, Hun Mok K, O'Sullivan J., The novel therapeutic potential of bovine "-lactalbumin made lethal to tumour cells and oleic acid in oral squamous cell carcinoma. (tcd.ie)

Furthermore, macrophages were shown to contribute to a niche that can support and maintain a breast CSC (BCSC) phenotype through heterotypic CD90/EphA4 signaling between macrophage and tumor cell 14 . (nature.com)
Stem cells numbers remain fixed because stem cells compete 'neutrally' for niche space (30). (hubrecht.eu)
Daughters of the small intestinal stem cells, the Paneth cells, serve as crypt niche cells by providing Wnt, Notch and EGF signals (33). (hubrecht.eu)
By targeting GPNMB along with CD133, combinatorial therapeutic regimens could target the cancer stem cell hierarchy and its supportive niche. (bmj.com)
Filipe Pereira has found his niche at the interface of cellular reprogramming and blood cell identity. (lu.se)

Following a clash with Goldstein over a series of experiments in which he demonstrated that results which Goldstein had published in Cell were experimental artifacts, he transferred to the Baylor College of Medicine, where he worked in the laboratory of another molecular gerontologist, James Smith, and graduated with a PhD in cell biology in 1989. (wikipedia.org)
His laboratory has also identified human stem cells including human leukemia stem cells that have helped to form the concept of cancer stem cells. (brandeis.edu)
This laboratory pursues several lines of investigation to understand how T cells contribute to autoimmune diseases and protection from infection, and how to modulate T cell immunity for therapeutic purposes in humans. (utsa.edu)
My laboratory also studies fertility preservation in male cancer patients. (utsa.edu)
The Hsieh laboratory is a neural stem cell biology laboratory that focuses on 4 major areas: (1) epilepsy-in-a-dish, (2) 3D cerebral organoids, (3) patient recruitment, and (4) mechanisms of adult neurogenesis. (utsa.edu)
I had heard about the European Molecular Biology Laboratory (EMBL), so I went there for a summer internship with Steve Cohen in my last year of university. (rupress.org)
2 Haematopoietic Stem Cell Biology Laboratory, MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom. (nih.gov)

Colorectal cancer is the third-leading cause of cancer related mortality in the United States. (mdpi.com)

He discovered several cancer and stem cell specific biomarkers. (madridge.org)

ABSTRACT This study examined haematopoietic stem cells of 19 high-risk cases of myelodysplastic syndrome (MDS) for apoptotic and anti-apoptotic signals and cellular proliferation and correlated these with clinical and cytogenetic subtypes, particularly trisomy 8. (who.int)

Far from extending life, long telomeres appear to cause cancer and a blood disorder known as CHIP, a condition that increases the risk of blood cancers and heart disease. (cdc.gov)

The diagnosis of diffuse large cell lymphoma is usually confirmed after positive findings are obtained from a lymph node biopsy specimen. (medscape.com)
Cutaneous T-cell lymphoma (CTCL) (see the image below) is a heterogeneous group of lymphoproliferative disorders characterized by localization of neoplastic T lymphocytes to the skin, with no evidence of extracutaneous disease at the time of diagnosis. (medscape.com)
Early patch-stage cutaneous T-cell lymphoma. (medscape.com)
Related articles include Cutaneous B-Cell Lymphoma and Cutaneous Pseudolymphoma . (medscape.com)
Among the changes to CTCL classification were the addition of primary cutaneous acral CD8 + T-cell lymphoma as a new provisional entity. (medscape.com)
Also, the term "primary cutaneous CD4 + small/medium T-cell lymphoma" was changed to "primary cutaneous CD4 + small/medium T-cell lymphoproliferative disorder" because of its indolent clinical behavior and uncertain malignant potential. (medscape.com)
Animal models for human tumour mental animals is not easy to answer does induce adult T-cell leukaemia/ viruses that make use of animal virus- for these agents, because cancer bi- lymphoma (ATLL), albeit in monkeys es are scarce. (who.int)

Dermal fibroblasts were taken from a 35-year old male and a 75-year-old male and used to create embryonic stem cells. (news-medical.net)
CD105 is expressed on vascular endothelial cells and placental syncytiotrophoblasts and at lower levels on stromal fibroblasts. (bdbiosciences.com)
that is histopathological y very simi- T cel s, B cel s, natural kil er cel s, LMP1 of EBV can transform ro- lar to that caused by hepatitis B vi- macrophages, and dendritic cells, dent fibroblasts and is expressed rus (HBV) in humans, but it does so and this humanized mouse model in most of the human cancers as- through a different mechanism. (who.int)

CHIP is more common in older individuals and is associated with increased risk of developing cardiovascular disease and both hematologic and solid cancer. (spaceref.com)

The aim of his master's thesis was to study the molecular mechanisms that downregulate MHC-I in advanced skin squamous cell carcinoma cells. (isglobal.org)
Cisplatin induces autophagy-associated apoptosis in human oral squamous cell carcinoma (OSCC) mediated in part through reactive oxygen species. (tcd.ie)

Hochedlinger pushes cells' developmental rewind buttons to examine their epigenetic history. (rupress.org)
Whether this trick was even possible was a fundamental question of developmental biology until Konrad Hochedlinger, as a Ph.D. student, finally delivered unequivocal proof ( 1 ). (rupress.org)

Cancer stem cells (CSCs) play an important role during metastasis, but the dynamic behavior and induction mechanisms of CSCs are not well understood. (nature.com)
At the apex of the hierarchy are the cancer stem cells (CSCs). (nature.com)
Cancer stem cells (CSCs) are defined as a small, self-renewing cell population within a tumor that can give rise to all other tumor cell types found within that tumor. (bio-connect.nl)
Thus, CSCs are considered to be critical targets for an important new generation of anti-cancer strategies. (bio-connect.nl)
Recently however, the ability to enrich and characterize CSC from several tumor types based on the expression of cell surface marker phenotypes is leading to significant progress in defining the nature and roles of CSCs in tumor formation, tumor plasticity, tumor recurrence, and tumor metastasis. (bio-connect.nl)
In vitro sphere formation assays are a type of colony formation assay used to evaluate the clonogenic potential of CSCs and other stem cells. (bio-connect.nl)
Tumor initiation, development, and relapse may be closely associated with cancer stem cells (CSCs). (nature.com)
Increasing evidence has shown that many cancers, including breast cancer exist CSCs. (nature.com)

constitutively released by murine main cells such as dendritic and transformed cell lines. (exposed-skin-care.net)
Therefore, new ways are needed to reprogram other cells into immune cells with the same capacity as the "natural" dendritic cells. (lu.se)
By using skin cells as the starting cell-type, he managed to identify the three molecules needed to "program" dendritic cells in just nine days. (lu.se)
In the next step, he used the same molecules to reprogram cancer cells into dendritic cells. (lu.se)

These highly specific CD44v monoclonal antibodies are highly recommended for measuring CD44v expression by flow cytometry and for enrichment of CSC populations by cell sorting. (bio-connect.nl)
Examples of preparative CSC enrichment from human cancer cell lines using anti-CD44 v9 antibody RV3 (Cat. (bio-connect.nl)

Notch signaling has been implicated in many microenvironmental processes associated with cancer progression such as vascular remodeling, immunosuppression, epithelial to mesenchymal transition (EMT), as well as maintenance of the CSC pool 21 . (nature.com)
Whereas the standard isoform of CD44 (CD44 s) is expressed predominantly in hematopoietic cells and normal epithelial cell subsets, CD44v (variant) isoforms contain insertions in the membrane-proximal extracellular region and are highly expressed in epithelial-type carcinomas. (bio-connect.nl)
This cell surface glycosylated 40 kD protein is highly expressed in bone marrow, colon, lung, and most normal epithelial cells and is expressed on carcinomas of gastrointestinal origin. (biolegend.com)

I think that the Center for Molecular Biology in Madrid has some of the greatest scientists in Spain. (rupress.org)
In 2013, scientists reported a successful SCNT procedure by modifying the protocol for specific human oocyte biology. (news-medical.net)
The relationship between cancer and chemicals captured the interest of scientists since the 18th century, and this having had a greater impact in the last century. (jcancer.org)
Scientists have found a way to possibly avoid using embryonic stem. (scitizen.com)
1. Cloning is an umbrella term traditionally used by scientists to describe different processes for duplicating biological material. (who.int)

At Geron, West initiated and managed programs in telomere biology relating to aging, cancer and human embryonic stem cell technology. (wikipedia.org)
In humans, Mendelian defects in several of these factors can result in abnormally short or dysfunctional telomeres, causing a group of rare heterogeneous premature-ageing diseases, termed telomeropathies, short-telomere syndromes or telomere biology disorders (TBDs). (cdc.gov)

Our overarching aim is to improve the management of myeloproliferative neoplasms and related conditions through better monitoring and therapeutic targeting of malignant stem cell populations. (ox.ac.uk)
Our overarching aim is to better characterise the cellular and molecular biology of these key populations of cells in order to understand how malignant stem cell populations might be more effectively targeted and eradicated. (ox.ac.uk)
We have developed new methods to study the molecular signatures of normal and malignant stem cell populations at the single-cell level. (ox.ac.uk)
After analyzing their data, Ebert's team recognized that individuals with this early pre-malignant state had a higher risk of developing blood cancer than those without it. (dana-farber.org)
Hepatocellular carcinoma (HCC), a highly malignant disease and the third leading cause of all cancer mortalities worldwide, often responses poorly to current treatments and results in dismal outcomes due to frequent chemoresistance and tumor relapse. (molcells.org)

Cancer theories, oncogenes, genomics. (jcancer.org)
The scientific path taken to understand cancer is paved with thousands of theories and scientific findings, from the time of Hippocrates to genomics today. (jcancer.org)

Astronauts are at higher risk for developing mutations-possibly linked to spaceflight-that can increase the risk of developing cancer and heart disease during their lifetimes, according to a first-of-its kind study from the Icahn School of Medicine at Mount Sinai. (spaceref.com)
Although CH is not necessarily an indicator of disease, it is associated with a higher risk for cardiovascular disease and blood cancer. (spaceref.com)
The presence of these mutations does not necessarily mean that the astronauts will develop cardiovascular disease or cancer, but there is the risk that, over time, this could happen through ongoing and prolonged exposure to the extreme environment of deep space," Dr. Goukassian said. (spaceref.com)
After more than 25 years of experiments with embryonic stem cells in animal models, researchers have yet to develop one successful treatment in mice for any disease that could be used as a model to undertake the first steps for a clinical trial with human patients. (freerepublic.com)
There is also peer-reviewed evidence of the therapeutic benefit to patients who have received an adult stem cell treatment for 72 disease and conditions. (freerepublic.com)
Currently, the only stem cells now used to treat disease are from blood cell-forming adult stem cells found in bone marrow. (goodmancoaching.nl)
These old Egyptian documents recorded cancer as a grave incurable disease and associated it to 'the curse of the gods' ( 1 ). (jcancer.org)
He believed that cancers, and more broadly any disease, developed whenever the balance in the four body humours (blood, phlegm, yellow bile, and black bile) were lost. (jcancer.org)
The pathology of chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF) and most lung cancers involves the small airway epithelium (SAE), the single continuous layer of cells lining the airways ≥ 6th generations. (biomedcentral.com)
To facilitate the study of the biology of the human SAE in health and disease, we immortalized and characterized a normal human SAE basal cell line. (biomedcentral.com)
In this context, if it is possible to immortalize normal human SAE BC that retain the capacity to differentiate to ciliated, secretory, and other differentiated cell types in vitro on air-liquid interface (ALI) culture, it would be very useful to the investigation of SAE biology in health and disease, and the assessment of pharmacologic agents targeted to modify dysregulated BC biology relevant to the pathogenesis of human lung disease. (biomedcentral.com)
Breast cancer is a heterogeneous disease with a large variabil- survival after adjuvant polychemotherapy was 10% (from ity in clinical outcome. (lu.se)

Hematopoietic stem cells in mammals are known to reside mostly in the bone marrow, but also transitively passage in small numbers in the blood. (uzh.ch)
We investigated the origin of SF3B1 mutations within the bone marrow hematopoietic stem and progenitor cell compartments in patients with MDS-RS. (nih.gov)
15]. The percentage of bone common of which are trisomy 8, mono- marrow blast cells for estimation of the Myelodysplastic syndrome (MDS) is somy 7 and 5q- [11]. (who.int)

The ability to avoid the consequences of exposure to high levels of ROS is required for cancer cell survival and propagation in vivo . (bio-connect.nl)
Lgr5 resides in Wnt receptor complexes and mediates signaling of the Wnt-agonistic R-spondins (31), explaining the unique dependence of Lgr5 stem cells on secreted R-spondins in vivo and in vitro. (hubrecht.eu)
Assessment of stem cell function in vitro as well as in vivo established that only HSCs and not investigated progenitor populations could propagate the SF3B1 mutated clone. (nih.gov)
This project will delve into innate immune cell function, establishing in vitro and in vivo systems test innate immune cell function in regeneration. (lu.se)

This was the first successful reprogramming of human somatic cells into embryonic stem cells using a cloning technique, SCNT. (news-medical.net)

At just 31 years old, Hochedlinger has already worked on therapeutic cloning in a mouse model ( 2 ), reprogramming cancer nuclei ( 3 ), and the molecular mechanisms controlling stem cell pluripotency ( 4 ). (rupress.org)
Possible mechanisms for gram for breast cancer in southern Sweden issued 1991, pre- recurrence after treatment are low initial drug sensitivity or menopausal lymph node positive (N+) breast cancer patients an acquired drug resistance. (lu.se)
Radiotherapy was delivered to ipsilateral axil- cancer patients in the future, it is essential to increase our lary and supraclavicular lymph nodes and the remaining knowledge in mechanisms responsible for drug resistance, breast parenchyma after breast conservation surgery or tho- and to define reliable indicators for response to therapy. (lu.se)

and from 2002 on pluripotency in embryonic stem cells in the lab of Ali H. Brivanlou. (eurostemcell.org)

They discovered DNA mutations, known as somatic mutations, in the blood-forming system (hematopoietic stem cells) in all 14 astronauts studied. (spaceref.com)
Their findings, published in the August issue of Nature Communications Biology, suggest that spaceflight could be associated with these mutations and emphasize the importance of ongoing blood screening of astronauts throughout their careers and during their retirement to monitor their health. (spaceref.com)
Somatic mutations are mutations that occur after a person is conceived and in cells other than sperm or egg cells, meaning they cannot be passed on to offspring. (spaceref.com)
Less understood are a newly recognized group of cancer-prone syndromes that are associated with mutations that lengthen telomeres. (cdc.gov)

Embryonic stem cells are immortal, and have the potential to develop into any type of adult cell, even after months growing in culture dishes. (news-medical.net)
By transferring adult cell DNA into an embryonic stem cell, it is possible to create a line of immortal embryonic cells that are able to develop into any type of adult cell, genetically identical to the donor. (news-medical.net)
The cloning method is based on the fact that cytoplasmic factors in mature, metaphase II oocytes are able to reset the identity of a transplanted adult cell nucleus to an embryonic state. (news-medical.net)
The adult cell nuclei were transferred into metaphase-II stage human oocytes, producing a karyotypically normal diploid embryonic stem cell line from each of the adult male donor cells. (news-medical.net)

Reprogramming immune cells or introducing targeted viruses and nanoparticles to seek out and kill cancer cells with few side-effects will be the standard operating procedure twenty years from now - and probably available outside the US in a decade. (fightaging.org)
They play a key role in orchestrating the immune response by "informing" other immune cells about the threat from foreign substances in the body. (lu.se)
In other words, using the molecules as a trojan horse to "force" cancer cells to develop into immune cells. (lu.se)
We know that innate immune cells are required for blastema progenitor cell formation, but are lacking an understanding of the immune cell processes and functions that are required for inducing and maintaining these progenitors cells. (lu.se)

Anatomy37

Organisms8

Diseases36

Chemicals and Drugs69

Analytical, Diagnostic and Therapeutic Techniques and Equipment49

Phenomena and Processes46

Disciplines and Occupations12

Technology, Industry, Agriculture3

Information Science4

Health Care4

Therapies14

Embryos13

Differentiation9

Tumor cells8

Genes17

Myeloid8

Tissue8

Clonal5

20231

Mammalian4

Genetics5

Progenitor cells3

Transplantation6

Gene10

Pluripotent5

Patient's3

Regenerative6

Genetic5

Research38

Heterogeneity3

Tissues7

Tumors5

Therapeutic potential3

Niche5

Laboratory7

Colorectal1

Biomarkers1

Haematopoietic stem1

Blood cancers1

Lymphoma7

Fibroblasts3

Hematologic1

Squamous cell carc2

Developmental2

CSCs8

Dendritic4

Enrichment2

Epithelial3

Scientists5

Telomere biology2

Malignant5

Genomics2

Disease12

Bone3

Vivo4

Somatic cells1

Mechanisms3

20021

Mutations4

Adult cell4

Immune cells4