• It is found in the core promoter regions of approximately 1% of human genes. (wikipedia.org)
  • HIF-1 is known to induce transcription of gene involved in energy metabolism, angiogenesis, apoptosis, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. (wikipedia.org)
  • This domain occurred 6 times on human genes ( 21 proteins). (umbc.edu)
  • The transcription factor ETS-1 can mediate the transcription of some downstream genes that play specific roles in the regulation of cancerous cell invasion and metastasis. (geneticsmr.com)
  • Overexpression of ELF4 boosted CRC metastasis via transactivating its downstream target genes, fibroblast growth factor receptor 4 (FGFR4) and SRC proto-oncogene, non-receptor tyrosine kinase, SRC . (thno.org)
  • Opposing actions of c-ets/PU.1 and c-myb protooncogene products in regulating the macrophage-specific promoters of the human and mouse colony-stimulating factor-1 receptor (c-fms) genes. (musc.edu)
  • We have learned that genes in mammalian cells are transcribed into messenger RNAs (mRNAs), which are to be translated into polypeptides (proteins). (intechopen.com)
  • Of the 31 genes, the 21 upregulated genes were primarily associated with cell paracrine and intracellular signaling, transcription regulation and cell adhesion and migration, and their transcriptional products included transforming growth factor-β2 (TGF-β2), insulin-like growth factor-binding protein 2 and transcriptional factor AP-2α/γ ( 11 ). (spandidos-publications.com)
  • By contrast, the 10 downregulated genes were primarily associated with epithelial membrane proteins ( 11 ). (spandidos-publications.com)
  • A diagram showing the major cancer genes for some cancers. (cancerquest.org)
  • Of the 30,000 or so genes that are currently thought to exist in the human genome , there is a small subset that seems to be particularly important in the prevention, development, and progression of cancer. (cancerquest.org)
  • These genes have been found to be either malfunctioning or non-functioning in many different kinds of cancer. (cancerquest.org)
  • Genes whose protein products stimulate or enhance the division and viability of cells. (cancerquest.org)
  • Genes whose protein products can directly or indirectly prevent cell division or lead to cell death. (cancerquest.org)
  • The normal versions of genes in the first group are called proto-oncogenes. (cancerquest.org)
  • The mutated or otherwise damaged versions of these genes are called oncogenes. (cancerquest.org)
  • Numerous genes have been identified as proto-oncogenes. (cancerquest.org)
  • As stated in the introduction to this section, the defective versions of these genes, known as oncogenes, can cause a cell to divide in an unregulated manner. (cancerquest.org)
  • ALL cancers have lots of additional changes, the so-called 'passenger' mutations, that may contribute to the cancer, but are not the main genes. (cancerquest.org)
  • By contrast, somatic alterations in the genes encoding Notch signaling components drive various types of human cancer, such as breast cancer, small-cell lung cancer (SCLC) and T-cell acute lymphoblastic leukemia (T-ALL) ( 6 - 9 ). (spandidos-publications.com)
  • EXPERIMENTAL DESIGN: To identify the genes involved in pancreatic cancer metastasis, we analyzed the gene expression profiles between highly metastatic Colo357L3.6pl and parental Colo357FG pancreatic cancer cell lines using cDNA microarrays and confirmed differential gene expression by reverse transcription-PCR, Western blotting, and immunologic analysis of 54 samples from pancreatic cancer patients. (duke.edu)
  • Human ELF-1, a transcription factor that appears to be required for the T- cell-receptor-mediated trans activation of HIV-2 genes. (expasy.org)
  • Proto-oncogenes are normal genes that help cells grow. (diaridelsestudiants.com)
  • In this review, the involvement of Y chromosome genes in male-specific diseases such as prostate cancer and the cases that are more prevalent in men, such as cardiovascular disease, neurological disease, and cancers, has been highlighted. (biomedcentral.com)
  • The role of MSY genes in important cellular processes such as transcription regulation, translation, and protein stability in males is vital not only in sex determination but also in sex-dependent organ development [ 3 ]. (biomedcentral.com)
  • Despite extensive studies on the effect of these genes on the development pathways, some MSY genes have remained as missing proteins with no experimental protein evidence due to highly transient and spatio-temporal restricted expression patterns. (biomedcentral.com)
  • MicroRNAs (miRNAs) are short (about 21 nucleotides long) strands of non-coding RNA that regulate the expression of multiple genes [ 1 ]. (biomedcentral.com)
  • They are important post-transcriptional regulators of gene expression in plants, metazoans, and mammals, and are predicted to control the activity of 30% of all protein-coding genes [ 2 ]. (biomedcentral.com)
  • The ETS family of oncogenic transcription factors in solid tumours. (musc.edu)
  • Recent global analyses of gene transcripts revealed that specific transcription factors (TFs) and their networking systems physiologically correspond to the onset of human diseases, including cancer. (intechopen.com)
  • This gene is a member of the Ets family of transcription factors and of the ternary complex factor (TCF) subfamily. (nih.gov)
  • Although OSM and IL-6 induced STAT (signal transducers and activators of transcription) factors to bind a high affinity Sis-inducible element DNA probe, binding to homologous TIMP-1 promoter sequences was not detected. (uea.ac.uk)
  • The Ets family of eukaryotic transcription factors is based around the conserved Ets DNA-binding domain. (hud.ac.uk)
  • TMPRSS2 is a prostate-specific and androgen-response gene that encodes a protein belonging to the serine protease family, which functions in prostate carcinogenesis and relies on gene fusion with ETS transcription factors, such as ERG and ETV1 (8). (diaridelsestudiants.com)
  • ERG is a member of the ETS (erythroblast transformation-specific) family of transcription factors. (diaridelsestudiants.com)
  • These findings are significant, since they provide novel molecular insights into the functions of ETS transcription factors in mammary cell transformation. (biomedcentral.com)
  • The human ETS (E26 Transformation-Specific) protein family is a diverse group of 27 known transcription factors that regulate such varied cellular processes as differentiation and apoptosis, but also appear to induce oncogenesis when mutated or aberrantly expressed [ 1 - 4 ]. (biomedcentral.com)
  • ETS family of transcription factors including Elk1, ETS1 and ETS2 are some of the well-known targets for the EGFR-Ras-MEK1/2 signaling pathway [11]. (researchassistantresume.com)
  • ETS1 is usually Narlaprevir a founding family member of ETS-domain transcription factors. (researchassistantresume.com)
  • An exciting finding is that in approximately half of the cases, there are recurrent chromosomal rearrangements resulting in the fusion of transmembrane protease serine 2 (TMPRSS2 ) and a member of the ETS family transcription factors , most commonly ERG . (medscape.com)
  • The role of two members of the ETS (E26 avian leukemia oncogene) family of transcription factors, ETS-1 and ETS-2, has been investigated in many cancers but has not yet been studied in ocular tumors. (molvis.org)
  • Overexpression of LKLF in lung epithelial cells increases cytosolic phospholipase A2, which has shown to be the cause of tumorigenesis of non-small-cell lung cancer. (wikipedia.org)
  • Using a CRISPR Cas9-guided immunoprecipitation assay, we identify a circular RNA in the FLI1 promoter chromatin complex, consisting of FLI1 exons 4-2-3, referred to as FECR1.Overexpression of FECR1 enhances invasiveness of MDA-MB231 breast cancer cells. (biomedcentral.com)
  • Mitogenic signaling by colony-stimulating factor 1 and ras is suppressed by the ets-2 DNA-binding domain and restored by myc overexpression. (musc.edu)
  • Scholars@Duke publication: Overexpression of tropomysin-related kinase B in metastatic human pancreatic cancer cells. (duke.edu)
  • CONCLUSION: These results suggest that overexpression of TrkB and activation of mitogen-activated protein kinase and AP-1, which may in turn induce the expression of vascular endothelial growth factor and interleukin 8, may mediate the cardinal clinical features of locally aggressive growth and metastasis of pancreatic cancer. (duke.edu)
  • Overexpression of one ETS protein in particular, the epithelium-specific ETS factor ESE-1, is implicated in human mammary transformation. (biomedcentral.com)
  • These genetic alterations often results in overexpression or activity of proto-oncogenes and inhibition of the function of tumor suppressor [1], [2].Therefore, understanding of the mechanisms by which the activity of both proto-oncogenes and tumor suppressors is usually altered in malignancy is usually crucially important both academically, and for development of new approaches to target malignancy cells for therapy. (researchassistantresume.com)
  • The overexpression of a membrane protein designated P-glycoprotein (P-gp) is a typical phenotypic marker of pleiotropic drug resistance. (ashpublications.org)
  • Galectin-1 knockdown reduced sorafenib resistance in Huh-7/SR cells, whereas Galectin-1 overexpression in Huh-7 cells increased sorafenib resistance. (aging-us.com)
  • Galectin-1 overexpression promoted the phosphorylation of AXL receptor tyrosine kinase (AXL) and MET proto-oncogene, receptor tyrosine kinase (MET) signaling, which increased sorafenib resistance. (aging-us.com)
  • Chromosome 1 open reading frame 198 (C1orf198) is a protein that in humans is encoded by the C1orf198 gene. (wikipedia.org)
  • C1orf198 is a protein-encoding gene found on the reverse strand of chromosome 1 at the locus 1q42. (wikipedia.org)
  • The Fli-1 gene was initially described in Friend virus-induced erythroleukemias as a site for virus integration. (umbc.edu)
  • Ets-2 interacts with co-repressor BS69 to repress target gene expression. (musc.edu)
  • Non-nuclear oncogenes and the regulation of gene expression in transformed cells. (musc.edu)
  • The larger the gene name, the more frequently that gene is defective in that cancer type. (cancerquest.org)
  • Note that by convention gene names are italicized and the proteins they make are not. (cancerquest.org)
  • As an example TP 53 refers to the gene and p53 refers to the protein. (cancerquest.org)
  • We have two copies of each gene and for oncogenes, a single defective copy is enough to cause a cell to divide. (cancerquest.org)
  • The protein encoded by this gene is phosphorylated by the kinases, MAPK1 and MAPK8. (nih.gov)
  • Polymerase chain reaction deletion analysis of the murine TIMP-1 proximal promoter in chloramphenicol acetyltransferase reporter gene constructs identified an AP-1 element (-59/-53) that allows maximal responsiveness to OSM in HepG2 cells. (uea.ac.uk)
  • Phorbol 13-myristate 12-acetate could also induce c-Fos but could not regulate the TIMP-1 reporter gene constructs. (uea.ac.uk)
  • We evaluated gene expression signatures associated with outcome in a large cohort of patients with early stage (Barcelona-Clinic Liver Cancer 0/A), single-nodule HCC and heterogeneity of signatures within tumor tissues. (gsea-msigdb.org)
  • Evolution of the ets gene family. (expasy.org)
  • ERG (ETS-related gene) is an oncogene. (diaridelsestudiants.com)
  • The ERG gene encodes for a protein, also called ERG, that functions as a transcriptional regulator. (diaridelsestudiants.com)
  • An oncogene is any gene that causes cancer. (diaridelsestudiants.com)
  • Proto-oncogenes only cause cancer when a mutation occurs in the gene that results in the gene being permanently turned on. (diaridelsestudiants.com)
  • The ER81 ETS protein, for example, is activated in human breast cancer cells by the oncoprotein HER-2, resulting in over-expression of the prosurvival telomerase reverse transcriptase (hTERT) gene [ 6 ]. (biomedcentral.com)
  • [ 5 ] The length of a polymorphic CAG repeat region in the first exon of the AR gene appears to explain the racial differences in the incidence of prostate cancer. (medscape.com)
  • Using semi-quantitative reverse-transcription polymerase chain reaction (RT-PCR) and western blots experiments, we compared changes in ETS-1 and ETS-2 expression, their protein levels, and the regulation of some of their target gene expressions at different stages of the ocular tumoral progression in the transgenic mouse model, Tyrp-1-TAg, with those in normal eyes from control mice of the same age. (molvis.org)
  • This gene is located within a chromosomal region that shows loss of heterozygosity in some bladder cancers. (cancerindex.org)
  • SAM Pointed domain of FLI-1 (Friend Leukemia Integration) subfamily of ETS transcriptional regulators is a putative protein-protein interaction domain. (umbc.edu)
  • Transfection studies also showed that 3'-deletion of sequences downstream of the transcriptional start site (+1/+47) markedly reduced OSM -fold induction. (uea.ac.uk)
  • Human ERF, a potent transcriptional repressor that binds to the HI element of the Ets-2 promoter. (expasy.org)
  • FLI-1, a sequence specific transcriptional activator. (expasy.org)
  • PU.1 is probably a transcriptional activator that may be specifically involved in the differentiation or activation of macrophages or B cells. (expasy.org)
  • ESE-1 initiates transformation of MCF-12A cells via a non-transcriptional, cytoplasmic process that is mediated by a unique 40-amino acid serine and aspartic acid rich (SAR) subdomain, whereas, ESE-1's nuclear transcriptional property is required to maintain the transformed phenotype of MCF7, ZR-75-1 and T47D breast cancer cells. (biomedcentral.com)
  • While previous publications have established ESE-1's transcription factor function, we have reported that ESE-1 initiates transformation of MECs via a novel non-nuclear, non-transcriptional mechanism [ 13 ]. (biomedcentral.com)
  • Establishing the transcriptional programme for blood: the SCL stem cell enhancer is regulated by a multiprotein complex containing Ets and GATA factors. (ox.ac.uk)
  • A ubiquitously expressed sequence-specific transcriptional repressor that is normally the target of signaling by NOTCH PROTEINS. (harvard.edu)
  • RB transcriptional corepressor 1 [Source:HG. (gsea-msigdb.org)
  • see RTKRas/MAP kinase signaling ), LIN-12 (see LIN-12/Notch signaling in C. elegans ), and WNT (see Wnt signaling ), as well as the functions of the SynMuv and mediator proteins (see Transcriptional regulation ). (wormbook.org)
  • Extracellular signal-regulated kinases 1 and 2 were activated and Elk-1 and AP-1 DNA binding activity was induced in Colo357L3.6pl cells. (duke.edu)
  • However, whether Galectin-1 regulates receptor tyrosine kinases by sensitizing HCC to sorafenib remains unclear. (aging-us.com)
  • OSM stimulated a rapid and transient increase in c-Fos mRNA and nuclear protein that coincided with complex 2 formation. (uea.ac.uk)
  • Malignant extracellular vesicles carrying MMP1 mRNA facilitate peritoneal dissemination in ovarian cancer. (cusabio.com)
  • ETS-1 and ETS-2 mRNA and protein levels were much higher in the ocular tissues of Tyrp-1-TAg mice than in control ocular tissues from wild-type mice. (molvis.org)
  • Friend leukemia virus integration 1 (FLI1), an ETS transcription factor family member, acts as an oncogenic driver in hematological malignancies and promotes tumor growth in solid tumors. (biomedcentral.com)
  • The Notch signaling network exerts oncogenic and tumor‑suppressive effects in a cancer stage‑ or (sub)type‑dependent manner. (spandidos-publications.com)
  • It has been linked to malignancy since its identification as an oncogenic fusion with the product of c-Myb proto-oncogene in the. (researchassistantresume.com)
  • While there is some controversy surrounding recent research that claims that miR-155 may display anti-oncogenic or pro-immunological benefits (Cell Rep 2:1697-1709, 2012), most research seems to point to the importance of anti-miRs, with anti-miR-155 in particular, for cancer therapy. (biomedcentral.com)
  • Relative to the average human protein, C1orf198 is serine-rich, proline-rich, and tyrosine-poor. (wikipedia.org)
  • ABL proto-oncogene 1, non-receptor tyrosine. (gsea-msigdb.org)
  • MET proto-oncogene, receptor tyrosine kinas. (gsea-msigdb.org)
  • EGF-receptor and Notch signaling are antagonistic: EGF-receptor signaling leads to down-regulation of the Notch-like receptor LIN-12 , while LIN-12 signaling induces negative regulators of EGF-receptor signaling such as MAP kinase phosphatase LIP-1 and the tyrosine kinase ARK-1. (wormbook.org)
  • The FLI-1 protein participates in regulation of cellular differentiation, proliferation, and survival. (umbc.edu)
  • These data suggest that FECR1 circular RNA acts as an upstream regulator to control breast cancer tumor growth by coordinating the regulation of DNA methylating and demethylating enzymes. (biomedcentral.com)
  • ELK4 promotes the development of gastric cancer by inducing M2 polarization of macrophages through regulation of the KDM5A-PJA2-KSR1 axis. (nih.gov)
  • These results also suggest that in addition to its established role in invasion and angiogenesis, ETS1 may support malignant cellular Narlaprevir growth via regulation of CIP2A expression and protein phosphatase 2A inhibition. (researchassistantresume.com)
  • In the present study, we investigated the sequential regulation of Elk-1 and Egr-1 on As3+-induced GADD45alpha, an effector of G2/M checkpoint. (omeka.net)
  • Additionally, DBC1 knockdown eliminated the up-regulation of MMP7, EMT-related proteins, and cell cycle-related proteins as well as the enhanced proliferation and invasiveness induced by ZNF326. (cancerindex.org)
  • E26 transformation-specific (ETS) Proto-oncogene 1 functions as an oncogene and plays a key role in the progression of certain cancer. (wikipedia.org)
  • Transmembrane serine protease 2 (TMPRSS2) is a cell surface protein primarily expressed by endothelial cells across the respiratory and digestive tracts. (diaridelsestudiants.com)
  • As a serine protease, it is involved in the cleaving peptide bonds of proteins that have serine as the nucleophilic amino acid within the active site. (diaridelsestudiants.com)
  • At cellular level, the trans-membrane protease serine 2 (TMPRSS2) primes the spike protein of human coronaviruses and facilitates cell entry and infection. (diaridelsestudiants.com)
  • Serine protease inhibitors, or serpins, comprise a family of proteins that antagonize the activity of serine proteases. (diaridelsestudiants.com)
  • Raf-1 proto-oncogene, serine/threonine kina. (gsea-msigdb.org)
  • Nowadays, lncRNAs can play important roles in cancer progression by combining with miRNAs, activating molecular targets and other ways, and are also related to the diagnosis, treatment and prognosis for cancer, such as prostate cancer. (bvsalud.org)
  • Here, we investigated the function of E74-like factor 4 (ELF4), an ETS family member, in facilitating CRC progression. (thno.org)
  • Due to the critical role of CAFs during cancer progression, the genetic characterization of CAFs aids in the investigation of cancer therapy. (spandidos-publications.com)
  • Finally, CAFs promote cancer progression and act in cancer cell drug resistance. (spandidos-publications.com)
  • Galectin-1 modulates cell-cell and cell-matrix interactions and plays a crucial role in HCC progression. (aging-us.com)
  • This review article focuses on the role of honey in modulating the development and progression of tumors or cancers. (mdpi.com)
  • Expression of ETS1was increased in cancer tissues as compared with the expression in corresponding non-neoplastic tissues. (wikipedia.org)
  • The proprotein convertase furin is a type I transmembrane protein that is ubiquitously expressed in eukaryotic tissues and cells. (diaridelsestudiants.com)
  • ECM consists of proteins and polysaccharides distributed in many different tissues of the body. (biomedcentral.com)
  • However, little is known about the mechanisms underlying the activation of this proto-oncogene in tumors. (biomedcentral.com)
  • Phase III clinical trials of Rova‑T for patients with small‑cell lung cancer and a phase III clinical trial of nirogacestat for patients with desmoid tumors are ongoing. (spandidos-publications.com)
  • Unlike cancer arising in the human population, tumors in genetically engineered mouse models arise in mice with well defined genetic backgrounds where genetic variability can be minimized. (molvis.org)
  • The article also underscores the various possible mechanisms by which honey may inhibit growth and proliferation of tumors or cancers. (mdpi.com)
  • The biological role and underlying mechanism of action of zinc-finger protein 326 (ZNF326) in malignant tumors, including breast cancer, are still not clear. (cancerindex.org)
  • Drosophila protein pointed (pnt) which is required for glial-neuronal cell interactions. (expasy.org)
  • Finally, using a monoclonal antibody targeting the SAR domain, we demonstrate that the SAR domain contains a region accessible for protein - protein interactions. (biomedcentral.com)
  • These data highlight that ESE-1 contains NLS and NES signals that play a critical role in regulating its subcellular localization and function, and that an intact SAR domain mediates MEC transformation exclusively in the cytoplasm, via a novel nontranscriptional mechanism, whereby the SAR motif is accessible for ligand and/or protein interactions. (biomedcentral.com)
  • It synthesizes information from ten recent papers on miR-155, and includes an analysis and discussion of its association with cancer, interactions with other miRNAs, mechanisms of action, and the most promising available treatment options. (biomedcentral.com)
  • Genomatix predicted several promoters, but the best prediction was of a 1,223 bp long promoter that overlapped with exon 1 of C1orf198 by 82 bp. (wikipedia.org)
  • Using this CasIP assay, we identified FECR1, a FLI1 exonic circular RNA that binds to the FLI1 promoter and epigenetically activates FLI1 in breast cancer cells. (biomedcentral.com)
  • Proteins of the TCF subfamily form a ternary complex by binding to the the serum response factor and the serum reponse element in the promoter of the c-fos proto-oncogene. (nih.gov)
  • Thus, OSM (but not IL-6) stimulates c-Fos, which participates in maximal activation of TIMP-1 transcription, likely in cooperation with other factors such as SP1 or as yet unidentified mechanisms involving the +1 to +47 region of the promoter. (uea.ac.uk)
  • It might have an important polymorphic association at the promoter regions of several MMPs such as MMP-1 (-1607 1G/2G), MMP-2 (-1306 C/T), MMP-3 (-1171 5A/6A), MMP-9 (-1562 C/T) and TIMP-2 (-418 G/C or C/C). Tissue inhibitors of metalloproteinases (TIMPs) are naturally occurring inhibitors of MMPs, which inhibit the activity of MMPs and control the breakdown of ECM. (biomedcentral.com)
  • Furthermore, we discuss recent advances in drug development for inhibition of Ets factors, and the roles structural biology can play in their future. (hud.ac.uk)
  • These results together suggest that inhibition of the pathway activity both at the level of the receptor, and Narlaprevir its downstream effectors may be required for an effective anti-cancer therapy. (researchassistantresume.com)
  • Advanced and metastatic prostate cancers require systemic therapies, including hormonal inhibition, chemotherapy, and targeted agents. (bjbms.org)
  • Macrophage colony-stimulating factor promotes cell survival through Akt/protein kinase B. (musc.edu)
  • ets-2 is a target for an akt (Protein kinase B)/jun N-terminal kinase signaling pathway in macrophages of motheaten-viable mutant mice. (musc.edu)
  • Canonical Notch signaling activates the transcription of BMI1 proto‑oncogene polycomb ring finger, cyclin D1, CD44, cyclin dependent kinase inhibitor 1A, hes family bHLH transcription factor 1, hes related family bHLH transcription factor with YRPW motif 1, MYC, NOTCH3, RE1 silencing transcription factor and transcription factor 7 in a cellular context‑dependent manner, while non‑canonical Notch signaling activates NF‑κB and Rac family small GTPase 1. (spandidos-publications.com)
  • sphingosine kinase 1 [Source:HGNC Symbol;Ac. (gsea-msigdb.org)
  • The ULK3 Kinase Is Critical for Convergent Control of Cancer-Associated Fibroblast Activation by CSL and GLI. (harvard.edu)
  • Most benefits were demonstrated in cyclin dependent-kinase 12 ( CDK12) mutated cell lines when treated with anti-programmed cell death protein 1 (PD1) therapy. (bjbms.org)
  • S-phase kinase associated protein 2 [Source. (gsea-msigdb.org)
  • mitogen-activated protein kinase 11 [Source. (gsea-msigdb.org)
  • CD13/APN transcription is induced by RAS/MAPK-mediated phosphorylation of Ets-2 in activated endothelial cells. (musc.edu)
  • In most species where it has been sequenced, c-ets-1 exists in various isoforms generated by alternative splicing and differential phosphorylation. (expasy.org)
  • Mammalian ELK-1, ELK-3 (also known as Net or SAP-2) and ELK-4 (also known as SRF accessory protein 1 (SAP-1)), which all form a ternary complex with the serum response factor (SRF). (expasy.org)
  • Identification of ETS-like transcription factor 4 as a novel androgen receptor target in prostate cancer cells. (nih.gov)
  • Detection of TMPRSS2-ERG Fusion Transcript in Biopsy Specimen of Prostate Cancer Patients: A Single Centre Experience. (diaridelsestudiants.com)
  • Is there a link between prostate cancer and TMPRSS2? (diaridelsestudiants.com)
  • The association of diabetes with risk of prostate cancer defined by clinical and molecular features. (diaridelsestudiants.com)
  • DNA Damage Promotes TMPRSS2-ERG Oncoprotein Destruction and Prostate Cancer Suppression via Signaling Converged by GSK3beta and WEE1. (diaridelsestudiants.com)
  • Some of the ethnic differences in the incidence of prostate cancer are attributed to diets. (medscape.com)
  • [ 4 ] For example, Asians have the lowest incidence of prostate cancer, while Asian immigrants who have adopted Western-style diets have an increased incidence of the disease, although still less than that of the white population. (medscape.com)
  • Other lifestyle factors, such as sexual practices and occupation, are currently not considered important with regard to the development of prostate cancer. (medscape.com)
  • In this article, the role of Y chromosome in male-specific diseases (male infertility and prostate cancer (PC), and the ones which primarily affect men such as cardiovascular diseases, inflammatory diseases, and various types of cancers has been reviewed (Fig. 2 ). (biomedcentral.com)
  • Prostate cancer is one of the most significant causes of morbidity and mortality in male patients. (bjbms.org)
  • The occurrence of prostate cancer is associated with many risk factors, including genetic and hereditary predisposition. (bjbms.org)
  • The most common genetic syndromes associated with prostate cancer risk are BRCA -associated hereditary breast and ovarian cancer (HBOC) and Lynch syndrome. (bjbms.org)
  • Local-regional therapy, i.e., surgery is beneficial in early-stage prostate cancer management. (bjbms.org)
  • Castration-resistant prostate cancer (CRPC) usually involves the PI3K/AKT/mTOR pathway and requires targeted therapy. (bjbms.org)
  • Many genetic defects are listed as diagnostic, prognostic, and clinically actionable markers in prostate cancer. (bjbms.org)
  • This review summarizes the pathophysiological mechanisms and available targeted therapies for prostate cancer. (bjbms.org)
  • DBC1 promotes castration-resistant prostate cancer by positively regulating DNA binding and stability of AR-V7. (cancerindex.org)
  • Constitutively active AR-V7, one of the major androgen receptor (AR) splice variants lacking the ligand-binding domain, plays a key role in the development of castration-resistant prostate cancer (CRPC) and anti-androgen resistance. (cancerindex.org)
  • In the present paper, we review the progress made over the last decade to elucidate the structural mechanisms involved in modulation of DNA binding and protein partner selection during dimerization. (hud.ac.uk)
  • We see that Ets domains, although conserved around a core architecture, have evolved to utilize a variety of interaction surfaces and binding mechanisms, reflecting Ets domains as dynamic interfaces for both DNA and protein interaction. (hud.ac.uk)
  • We have studied the transgenic mouse strain, Tyrp-1-TAg, to try to gain insight into possible molecular mechanisms common to pigmented ocular neoplasms occurring spontaneously in the eyes of these mice and human choroidal melanoma. (molvis.org)
  • In mouse, Spi-1 is an oncogene involved in murine acute friend erythroleukemia. (expasy.org)
  • This is the first study describing the production and distribution of ETS-1 and ETS-2 mRNAs and proteins using in situ hybridization and immunohistochemistry in murine ocular tissue sections of normal control eyes and tumoral eyes from mice of the same age. (molvis.org)
  • Immunohistochemical staining showed that FLI1 is aberrantly overexpressed in advanced stage and metastatic breast cancers. (biomedcentral.com)
  • We hypothesized that these components might actively participate in the control of FLI1 in the development of breast cancers. (biomedcentral.com)
  • In this study, the effects of LINE-1 ORF-1p on ETS-1 activity and on the proliferation and invasion of human colorectal cancer LoVo cells were investigated. (geneticsmr.com)
  • Metastasis accounts for the high lethality of colorectal cancer (CRC) patients. (thno.org)
  • These effects of honey have been thoroughly investigated in certain cancers such as breast, liver and colorectal cancer cell lines. (mdpi.com)
  • The human proto-oncogene long interspersed nucleotide acid element-1 (LINE-1) open reading frame-1 protein (ORF-1p) is involved in the progress of several cancers. (geneticsmr.com)
  • The mutant proteins often retain some of their capabilities but are no longer sensitive to the controls that regulate the normal form of the protein. (cancerquest.org)
  • It is widely recognized that the accumulation of various harmful genetic alterations in normal cells may induce malignant cancer cells ( 1 ). (spandidos-publications.com)
  • Therefore, it has been demonstrated that genetic or epigenetic alterations may be responsible for the special features of CAFs ( Fig. 1 ) ( 10 ). (spandidos-publications.com)
  • For MMP-1(-1607) 1G/2G, a significant association was observed using the recessive genetic model. (cusabio.com)
  • The combined action of genetic and environmental factors is believed to underlie the etiology of esophageal cancer. (biomedcentral.com)
  • Some prostate cancers may have a genetic component. (medscape.com)
  • NOTCH1, NOTCH2, NOTCH3 and NOTCH4 are transmembrane receptors that transduce juxtacrine signals of the delta‑like canonical Notch ligand (DLL)1, DLL3, DLL4, jagged canonical Notch ligand (JAG)1 and JAG2. (spandidos-publications.com)
  • Stromal PTEN inhibits the expansion of mammary epithelial stem cells through Jagged-1. (musc.edu)
  • Breast cancer-associated fibroblasts confer AKT1-mediated epigenetic silencing of Cystatin M in epithelial cells. (musc.edu)
  • The protein-protein interaction (PPI) network was further constructed according to mRNAs in the miRNAs-mRNAs network. (biomedcentral.com)
  • these include the LIM domain protein LIN-11 , the Pax2/5/8 protein EGL-38 , the zinc finger protein LIN-29 , and the Nkx6.1/6.2 protein COG-1. (wormbook.org)
  • The carboxy-terminal catalytic domain of the GTPase-activating protein inhibits nuclear signal transduction and morphological transformation mediated by the CSF-1 receptor. (musc.edu)
  • Ets-1 differs slightly from v-ets at its carboxy-terminal region. (expasy.org)
  • Among the ETS family members, Friend leukemia virus integration 1 ( FLI1 ) was first identified as a proto-oncogene activated by proviral integration in F-MuLV-induced erythroleukemias [ 4 ]. (biomedcentral.com)
  • solute carrier family 38 member 1 [Source:H. (gsea-msigdb.org)
  • transmembrane 4 L six family member 1 [Sour. (gsea-msigdb.org)
  • The ETS family transcription factor ESE-1 is often overexpressed in human breast cancer. (biomedcentral.com)
  • Avian species do not have brown adipose tissue (BAT), and lack Uncoupling Protein 1 ( UCP1 ) [ 12 ]. (biomedcentral.com)
  • Integration of human intelligence, cognitive computing and explainable artificial intelligence is necessary to construct a Notch‑related knowledge‑base and optimize Notch‑targeted therapy for patients with cancer. (spandidos-publications.com)
  • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA563995(MMP1 Antibody) at dilution 1/60, on the right is treated with fusion protein. (cusabio.com)
  • Localization and modulation of the DNA-binding activity of the human c-ets-1 protooncogene. (expasy.org)
  • CIP2A promotes malignant cell growth and is over expressed at high frequency (40C80%) in most of the human cancer types. (researchassistantresume.com)
  • Narlaprevir Thus, ETS1 is probably mediating high CIP2A expression in human cancers with increased EGFR-MEK1/2-ERK pathway activity. (researchassistantresume.com)
  • With the launch of the human proteome project (HPP), the association of Y chromosome proteins with pathological conditions has been increasingly explored. (biomedcentral.com)
  • Sterile alpha motif (SAM)/Pointed domain of friend leukemia integration 1 transcription activator. (umbc.edu)
  • Notch signaling is aberrantly activated in breast cancer, non‑small‑cell lung cancer and hematological malignancies, such as T‑cell acute lymphoblastic leukemia and diffuse large B‑cell lymphoma. (spandidos-publications.com)
  • ADCs and CAR‑Ts could alter the therapeutic framework for refractory cancers, especially diffuse‑type gastric cancer, ovarian cancer and pancreatic cancer with peritoneal dissemination. (spandidos-publications.com)
  • Our results also imply that TrkB receptor may be a novel therapeutic target for pancreatic cancer. (duke.edu)
  • Consequently, Galectin-1 is a promising therapeutic target for reducing sorafenib resistance and sorafenib-mediated ferroptosis in patients with HCC. (aging-us.com)
  • the expression level of ZNF326 was inversely associated with advanced pTNM stage (P = 0.002), positive lymph node metastasis (P = 0.004), poor prognosis in patients with breast cancer (P = 0.0097), and ER/PR/Her2 status (P = 0.013). (cancerindex.org)
  • Therefore, we concluded that ZNF326 is highly expressed in breast cancer, is associated with poor prognosis, and plays a vital role in promoting the malignant phenotype of breast cancer cells by interacting with DBC1. (cancerindex.org)
  • In non-small cell lung cancer, the FLI1 expression score is associated with the stage of SCLC. (biomedcentral.com)
  • Some proto-oncogenes work to regulate cell death. (cancerquest.org)
  • The proto-oncogenes that have been identified so far have many different functions in the cell. (cancerquest.org)
  • However, Notch signaling is inactivated in small‑cell lung cancer and squamous cell carcinomas. (spandidos-publications.com)
  • Matrix metalloproteinase 1(MMP1), which was downregulated in myelodysplastic syndromes (MDS)-mesenchymal stromal cells (MSCs), was identified as an inhibitory factor of MDS cell proliferation. (cusabio.com)
  • Methods Pathways governing airway mucus cell differentiation include SRY (sex determining region Y)-box 2 (SOX2), Notch, forkhead box A3(FOXA3)/SAM pointed domain containing ETS transcription factor (SPDEF), epidermal growth factor (EGF) and the EGF-related neuregulins NRG1α and NRG1β. (bmj.com)
  • One of the main characteristics of cancer is uncontrolled cell growth. (diaridelsestudiants.com)
  • Small cell carcinoma of the prostate is rare, accounting for less than 1% of all prostate cancers . (medscape.com)
  • In normal control adult mouse eyes, ETS-1 was mostly present in the nuclei of all neuroretinal layers whereas ETS-2 was mostly localized in the cytosol of the cell bodies of these layers with a smaller amount present in the nuclei. (molvis.org)
  • It constitutes fibrous proteins such as collagen and elastin, elongated glycoproteins such as fibronectin and laminin, which provide cell matrix adhesion. (biomedcentral.com)
  • Herein, we established a sorafenib-resistant HCC cell line (Huh-7/SR) and determined that Galectin-1 expression was significantly higher in Huh-7/SR cells than in parent cells. (aging-us.com)
  • Ets2 in tumor fibroblasts promotes angiogenesis in breast cancer. (musc.edu)
  • 2021). CYK-1/Formin activation in cortical RhoA signaling centers promotes organismal left-right symmetry breaking. (caltech.edu)
  • EGF promotes the 1 ° fate while LIN-12 promotes the 2 ° fate. (wormbook.org)
  • ZNF326 promotes a malignant phenotype of breast cancer by interacting with DBC1. (cancerindex.org)
  • PURPOSE: Pancreatic adenocarcinoma is currently the fourth leading cause of cancer death in the United States, and most pancreatic cancers develop locally advanced disease or metastasis at the time of diagnosis. (duke.edu)
  • Exosomes are small membrane-enclosed vesicles that are released by most living cells and harbor a diverse array of proteins, nucleic acids, and lipid cargos. (bvsalud.org)
  • CAFs provide cancer cells with nutrition and promote the proliferation, invasion and metastasis of cells ( 6 - 9 ). (spandidos-publications.com)
  • CAFs maintain their phenotype for numerous passages during culture in vitro without exposure to cancer cells, while NFs cannot be infinitely proliferous like cancer cells ( 10 ). (spandidos-publications.com)
  • In normal cells, both internal and external signals control the activity of the oncogenes. (cancerquest.org)
  • Notch signaling cascades crosstalk with fibroblast growth factor and WNT signaling cascades in the tumor microenvironment to maintain cancer stem cells and remodel the tumor microenvironment. (spandidos-publications.com)
  • Small-molecule inhibitors, antagonistic monoclonal antibodies (mAbs), antibody-drug conjugates (ADCs), bispecific antibodies or biologics (bsAbs) and chimeric antigen receptor-modified T cells (CAR-Ts) targeting Notch signaling components have been developed as investigational anti-cancer drugs ( 10 - 12 ). (spandidos-publications.com)
  • Mucus cells lining abnormal airways from patients with IPF expressed MUC5B and SOX2 but lacked SAM pointed domain containing ETS transcription factor (SPDEF) and forkhead box A3(FOXA3). (bmj.com)
  • Galectin-1 regulated ferroptosis by inhibiting excessive lipid peroxidation, protecting sorafenib-resistant HCC cells from sorafenib-mediated ferroptosis. (aging-us.com)
  • These findings indicate that Galectin-1 regulates sorafenib resistance in HCC cells through AXL and MET signaling. (aging-us.com)
  • and promoted the proliferation and invasiveness of breast cancer cells both in vivo and in vitro. (cancerindex.org)
  • Mechanistically, co-immunoprecipitation and immunofluorescence assays both demonstrated that ZNF326 interacted with deleted in breast cancer-1 (DBC1) in breast cancer cells. (cancerindex.org)
  • Nuclear factors bound to SP1 and Ets sequences were detected, but were not altered upon OSM stimulation. (uea.ac.uk)
  • These exosomes offer valuable biomarkers that may offer insights regarding as a range of physiological and pathological processes, including immune responses, cancer development, pregnancy, and diseases of the central nervous system. (bvsalud.org)
  • Characterization of SAP-1, a protein recruited by serum response factor to the c-fos serum response element. (nih.gov)
  • Liver cancer is the most common malignant neoplasm worldwide [ 1 ]. (aging-us.com)
  • Approximately 90% of patients with liver cancer have hepatocellular carcinoma (HCC) [ 2 ]. (aging-us.com)
  • Since its discovery, miR-155 has been implicated in promoting cancers of the breast, lung, liver, and lymphatic system. (biomedcentral.com)