• alphav-beta3-integrin is a major sensor and activator of innate immunity to herpes simplex virus-1. (unibo.it)
  • Furthermore, neither anti-mouse beta3 integrin function-blocking monoclonal antibody (mAb) nor alphav integrin function-blocking mAb inhibited sperm binding to or fusion with beta1 integrin null eggs. (lu.se)
  • Thus, function of beta3 or alphav integrins does not seem to be involved in compensating for the absence of beta1 integrins. (lu.se)
  • Intracellular calcium and calcineurin regulate neutrophil motility on vitronectin through a receptor identified by antibodies to integrins alphav and beta3. (rush.edu)
  • Integrin beta3 occurs as three alternatively spliced isoforms, designated beta3A-C. (lookformedical.com)
  • Colon cancer cells overexpressing Tβ 4 also exhibited enhanced cell migration, due in part to the activation of the Rac1 signaling pathway ( 3 ). (spandidos-publications.com)
  • Migration of brain tumor cells on extracellular matrix proteins in vitro correlates with tumor type and grade and involves alphaV and beta1 integrins. (thieme-connect.com)
  • Various beta1 integrins and alphav integrins are present on mouse eggs. (lu.se)
  • Here, we show that although this receptor is present on most vascular and blood cells, the key regulatory function in tumor and wound angiogenesis is performed by β 3 integrin on bone marrow-derived cells (BMDCs) recruited to sites of neovascularization. (rupress.org)
  • Integrins are not constitutively active but rather exist in multiple activation states wherein ligand binding stability is related to the activation status of the receptor. (thno.org)
  • It is expressed on erythrocytes and erythroblasts, and serves as a receptor for LFA-1, Mac-1, and CD11c/CD18, plus alpha 4 beta 1 and alpha-V containing integrins. (rndsystems.com)
  • Integrin alpha-5/beta-1 is a receptor for fibrinogen. (biossantibodies.com)
  • Integrin alpha-4/beta-1 is a receptor for VCAM1. (biossantibodies.com)
  • Integrin alpha-3/beta-1 is a receptor for epiligrin, thrombospondin and CSPG4. (biossantibodies.com)
  • Some of these integrins are also reported to be receptors for ADAMs, which are expressed on sperm. (lu.se)
  • These results indicate that none of the integrins known to be present on mouse eggs or to be ADAM receptors are essential for sperm-egg binding/fusion, and thus, egg integrins may not play the role in gamete fusion previously attributed to them. (lu.se)
  • Integrins are heterodimeric, transmembrane receptors that function as mechanosensors, adhesion molecules and signal transduction platforms in a multitude of biological processes. (thno.org)
  • Integrins are heterodimeric cell surface receptors found in nearly all metazoan cell types, composed of non-covalently linked α and β subunits. (thno.org)
  • Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. (biossantibodies.com)
  • Integrins alpha-2/beta-1, alpha-3/beta-1, alpha-4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha-11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. (biossantibodies.com)
  • Integrin alpha-1/beta-1, alpha-2/beta-1, alpha-6/beta-1 and alpha-7/beta-1 are receptors for lamimin. (biossantibodies.com)
  • Vitaxin (MEDI-523) is a humanized monoclonal antibody against the vascular integrin alpha-v beta-3. (wikipedia.org)
  • Extracellular factors that influence integrin activation are ligand binding, divalent cation concentration, chemokine signaling and mechanical stress. (thno.org)
  • Angiogenesis is an important component of cancer growth, invasion and metastasis. (biomedcentral.com)
  • Angiogenesis is a pivotal component of cancer growth, including invasion and metastasis. (biomedcentral.com)
  • While metastasis ranks among the most lethal of all cancer-associated processes, on the molecular level, it remains one of the least well understood. (biomedcentral.com)
  • Initial observations that many characteristics of cancer metastasis appear to be recapitulations of key features of EMT/MET, led to the hypothesis that similar, if not identical, molecular mechanisms may be involved [ 2 - 4 ]. (biomedcentral.com)
  • Indeed, while it is clear that cancer metastasis must involve detachment of cancer cells from the primary tumor, such a phenomenon could well be attributed to mutation(s) and/or aberrant gene expression patterns in one or a few genes and not necessarily reflect involvement of a more coordinated process such as EMT [ 9 ]. (biomedcentral.com)
  • Ovarian cancer metastasis is primarily due to the exfoliation of malignant cells or cell aggregates from the primary tumor into the abdominal cavity and their subsequent spread and attachment to visceral and parietal peritoneal surfaces of abdominal organs such as the omentum. (biomedcentral.com)
  • Moreover we examine the role of a monoclonal antibody (mAb) against HSP90, mAb 4C5, regarding these interactions and its value as a potential inhibitor of human breast cancer cell invasion and metastasis. (biomedcentral.com)
  • Finally mAb 4C5 significantly inhibits the metastatic deposit formation of MDAMB453 cells, by preventing their extravasation and infiltration in the lung tissue and therefore it could be used as a potential therapeutic agent for cancer metastasis. (biomedcentral.com)
  • Thus, inhibition of invasion and metastasis of cancer cells is of great importance in the treatment of cancer. (biomedcentral.com)
  • Integrins also function in pathological processes such as inflammation, wound healing, angiogenesis, and tumor metastasis. (thno.org)
  • Inositol Hexaphosphate and Inositol Inhibit Colorectal Cancer Metastasis to the Liver in BALB/c Mice. (biossantibodies.com)
  • Oral squamous cell carcinoma (OSCC) is the most common type of head and neck malignant tumor and is ranked the eighth leading cause of cancer worldwide. (nature.com)
  • Thus, β 3 integrin has the potential to control processes such as tumor growth and wound healing by regulating BMDC recruitment to sites undergoing pathological and adaptive angiogenesis. (rupress.org)
  • Similar to most cancers of mesenchymal origin, little or nothing is demonstrated by blood work, although the sudden development of profound thrombocytopenia in patients with angiosarcoma may either suggest rapid growth of the primary tumor or herald the development of metastatic disease. (medscape.com)
  • The dissemination of tumor cells from their primary site of growth to distant organs is the major cause of morbidity and death among cancer patients [ 1 , 2 ]. (biomedcentral.com)
  • This review focusses on clinical aspects of treatment of breast cancer with monoclonal antibodies, and tyrosine kinase and mammalian target of rapamycin (mTOR) inhibitors. (biomedcentral.com)
  • It is shown to be a promising angiogenesis inhibitor used in the treatment of some forms of cancer. (wikipedia.org)
  • This integrin may regulate angiogenesis and cancer progression. (assaygenie.com)
  • Using knockin mice expressing functionally stunted β 3 integrin, we show that bone marrow transplantation rescues impaired angiogenesis in these mice by normalizing BMDC recruitment. (rupress.org)
  • Therefore, inhibition of angiogenesis is an attractive strategy for treatment of cancer. (biomedcentral.com)
  • Integrins are heterodimeric integral membrane proteins composed of an alpha subunit and a beta subunit that function in cell surface adhesion and signaling. (assaygenie.com)
  • Finally, we have presented data indicating that surface HSP90 interacts specifically with the extracellular domain of HER-2 and that this interaction which is necessary for the receptor's activation leading to breast cancer cell invasion, is disrupted by mAb 4C5 [ 14 ]. (biomedcentral.com)
  • Integrin-mediated interactions with the extracellular matrix (ECM) are required for the attachment, cytoskeletal organization, mechanosensing, migration, proliferation, differentiation and survival of cells in the context of a multitude of biological processes including fertilization, implantation and embryonic development, immune response, bone resorption and platelet aggregation. (thno.org)
  • E/PCF-NPs show enhanced anti-cancer effects due to synergistic effects of chemotherapy with photothermal therapy and may be potential therapeutic agents for cancer treatment. (dovepress.com)
  • Therefore, pharmacological inhibition of integrins is of great interest for the treatment and prevention of disease. (thno.org)
  • In the absence of integrin ligation, these processes are abrogated therefore pharmacological inhibition of integrin ligation is of great interest for the therapy of numerous diseases resulting from abberant integrin mediated signaling. (thno.org)
  • The integrin tails have no intrinsic kinase activity but rather serve as a site for the docking of various kinases and related adaptor proteins that comprise focal adhesions. (thno.org)
  • Concentrated growth factor promotes Schwann cell migration partly through the integrin β1-mediated activation of the focal adhesion kinase pathway. (biossantibodies.com)
  • Heat shock protein 90 (HSP90) is a molecular chaperone that is considered a new target for the treatment of cancer. (biomedcentral.com)
  • The ITGB3 protein product is the integrin beta chain beta 3. (modellab.cn)
  • Herein, this review examines and evaluates the various drugs and compounds targeting integrins and the disease states in which they are implicated. (thno.org)
  • 2007) referred to the Compact disc146 epitope (Most cancers Cell Adhesion Molecule, MCAM) as an antigen associated with self-renewing human osteoprogenitors capable of HME formation when transplanted subcutaneously in hydroxyapatite/tri-calcium phosphate (HA/TCP)/fibrin constructs [11]. (opioid-receptors.com)
  • Oocyte-specific, beta1 integrin conditional knockout mice allowed us to obtain mature eggs lacking. (lu.se)
  • Capillary Electrophoresis Frontal Analysis for Characterization of Alpha-V Beta-3 Integrin Binding Interactions. (ubc.ca)
  • Using advanced imaging techniques such as optical coherence tomography (OCT), nonlinear interferometric vibrational imaging (NIVI), interferometric synthetic aperture microscopy (ISAM), and multi-photon microscopy, it is feasible to generate high-resolution, real-time, non-invasive images of biological tissue at the cellular and molecular level for diagnosing diseases such as cancer. (illinois.edu)
  • This mechanism of intra-abdominal metastatic spread allows for the capture and molecular comparison of primary and metastatic cancer cells isolated from the same patient, providing a favorable opportunity to evaluate the potential role of epithelial-to-mesenchymal transition (EMT) in the metastatic process. (biomedcentral.com)
  • The product of this gene belongs to the integrin alpha chain family. (assaygenie.com)
  • Gene expression profiling (Affymetrix, U133) was carried out on 14 matched sets of primary (ovary) and metastatic (omentum) ovarian cancer (serous adenocarcinoma) patient samples. (biomedcentral.com)
  • The researchers showed that removing a gene in the myofibroblasts that makes a specific subset of proteins called alpha v integrins blocks the ability of these cells to trigger activation of TGF beta. (healthmedicinet.com)
  • In tandem with the drug discovery research, scientists working on another part of the study found they could protect mice from pulmonary fibrosis, liver fibrosis and renal fibrosis by deleting a gene that makes the same specific integrins in myofibroblasts that were targeted by the drug. (healthmedicinet.com)
  • Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. (modellab.cn)
  • In situ hybridization studies have demonstrated expression of VEGF mRNA in many human tumours, including breast cancer. (biomedcentral.com)
  • This phase I trial identifies the best dose, possible benefits and/or side effects of BAY 1895344 in combination with chemotherapy in treating patients with solid tumors or urothelial cancer that has spread to other places in the body (advanced). (ucbraid.org)
  • Combining BAY 1895344 with chemotherapy treatment (cisplatin, or cisplatin and gemcitabine) may be effective for the treatment of advanced solid tumors, including urothelial cancer. (ucbraid.org)
  • This phase II trial studies how well Ataxia telangiectasia and Rad3-related (ATR) kinase inhibitor AZD6738 works alone or in combination with olaparib or durvalumab in treating participants with renal cell carcinoma (RCC), urothelial carcinoma, all pancreatic cancers, endometrial cancer, and other solid tumors excluding clear cell ovarian cancer that have spread to nearby tissue or lymph nodes or other parts of the body. (ucbraid.org)
  • Alternative integrins may be involved in sperm-egg binding and fusion and could compensate for the absence of alpha6beta1. (lu.se)
  • Ovarian Cancer Clinical Trial: Study of PF-06940434 in Patients With Advanced or Metastatic Solid Tumors. (survivornet.com)
  • Our results are consistent with a role of EMT in most if not all ovarian cancer metastases and demonstrate that identical morphologies between primary and metastatic cancer samples is insufficient evidence to negate a role of EMT in the metastatic process. (biomedcentral.com)
  • Clinical Cancer Research. (wikipedia.org)
  • We describe existing clinical trials of antiangiogenic agents and the challenges facing the clinical development and optimal use of these agents for the treatment of breast cancer. (biomedcentral.com)
  • At present, several antiangiogenic therapies are in clinical trials testing their promise in breast cancer. (biomedcentral.com)
  • Proceedings from conferences of the American Society of Clinical Oncology (ASCO), the American Association of Cancer Research (2005 to 2009), and the San Antonio Breast Cancer Symposium (2005 to 2009) were searched for relevant abstracts. (biomedcentral.com)
  • In the last two decades several integrin-targeted drugs have made their way into clinical use, many others are in clinical trials and still more are showing promise as they advance through preclinical development. (thno.org)
  • In vivo, SGN-B7H4V demonstrated strong antitumor activity in multiple xenograft models of breast and ovarian cancer, including xenograft tumors with heterogeneous B7-H4 expression, consistent with the ability of vedotin ADCs to elicit a bystander effect. (bvsalud.org)
  • Ovarian cancer is the most malignant of all gynecological cancers and is responsible for over 14,000 deaths per year in the United States alone [ 12 ]. (biomedcentral.com)
  • This phase II trial studies how well abemaciclib works in treating patients with ovarian or endometrial cancer that has an activation of the CDK4/6 pathway and that has come back (recurrent). (ucbraid.org)
  • Giving abemaciclib may work better for the treatment of recurrent ovarian and endometrial cancer. (ucbraid.org)
  • We found that the beta1 integrin null eggs were fully functional in fertilization both in vivo and in vitro. (lu.se)
  • An integrin beta subunit of approximately 85-kDa in size which has been found in INTEGRIN ALPHAIIB-containing and INTEGRIN ALPHAV-containing heterodimers. (lookformedical.com)
  • Integrin beta 3 is found along with the alpha IIb chain in platelets. (modellab.cn)
  • Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G-E-R in collagen. (biossantibodies.com)
  • Beta-1 integrins recognize the sequence R-G-D in a wide array of ligands. (biossantibodies.com)
  • We demonstrate that α v β 3 integrin enhances BMDC recruitment and retention at angiogenic sites by mediating cellular adhesion and transmigration of BMDCs through the endothelial monolayer but not their release from the bone niche. (rupress.org)
  • [ 2 ] Well- to moderately differentiated neuroendocrine neoplasms (WMD-NEN) are a highly heterogeneous group of tumors comprising low-grade (G1) and intermediate-grade (G2) NETs of the gastrointestinal tract, typical and atypical carcinoids of the lung and thymus, and other cancers such as medullary thyroid carcinoma and pheochromocytoma/paraganglioma. (oaepublish.com)
  • One persistent objection to the model is the fact that careful morphological examinations of human metastases have never uncovered the existence of cancer mesenchymal-like cells [ 9 ]. (biomedcentral.com)
  • Our results showed that both HSP90α and HSP90β are secreted by MDAMB453 human breast cancer cells and interact with MMP2 and MMP9. (biomedcentral.com)
  • MMPs have increased expression and activation in almost all human cancers[ 6 ]. (biomedcentral.com)
  • Integrin mediated cellular adhesion is dynamic process that is both indicative of and influenced by cell status. (thno.org)
  • A key adhesion molecule expressed by these cells is the α v β 3 integrin. (rupress.org)
  • Preclinical results provided here demonstrate that treatment of cancer cells with brentuximab vedotin or free MMAE leads to a catastrophic disruption of the microtubule network eliciting a robust endoplasmic reticulum (ER) stress response that culminates in the induction of the classic hallmarks of immunogenic cell death (ICD). (bvsalud.org)
  • In addition, integrin binding has been identified as a means of viral entry into cells [ 3 ]. (thno.org)
  • Ito et al ( 2 ) showed that overexpression of Tβ 4 enhanced the formation of actin-based pseudopodia and cell motility in prostate cancer cells, providing direct evidence that Tβ 4 plays a role in cell migration. (spandidos-publications.com)
  • Tandon M, Chen Z, Pratap J. Runx2 activates PI3K/Akt signaling via mTORC2 regulation in invasive breast cancer cells. (rush.edu)
  • Using alpha3 integrin null eggs, we found that the alpha3beta1 integrin was not essential for sperm-egg binding and fusion. (lu.se)
  • While experimentally supported by cell culture and animal model studies, the lack of unambiguous confirmatory evidence in cancer patients has led to persistent challenges to the model's relevance in humans. (biomedcentral.com)
  • Recently, we and others have identified a pool of HSP90 at the cell surface, where it was shown to be involved in cancer cell invasion [ 12 ]. (biomedcentral.com)
  • Integrin ligation via cell-to-cell and cell-to-matrix contacts transduces intracellular signaling events in a process called 'outside-in' signaling (Fig. 2 ). (thno.org)
  • Lineage-Specific Induced Pluripotent Stem Cell-Derived Smooth Muscle Cell Modeling Predicts Integrin Alpha-V Antagonism Reduces Aortic Root Aneurysm Formation in Marfan Syndrome Mice. (stanford.edu)
  • Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. (modellab.cn)
  • This is a Phase IB/II multi-cohort study designed to evaluate the efficacy and safety of targeted agents with or without cancer immune checkpoint therapy with atezolizumab in participant with recurrent and/or persistent endometrial cancer. (ucbraid.org)
  • The biodirectional nature of integrin mediated signaling allows both extra- and intracellular cues to regulate activation [ 4 ] (Fig. 1 ). (thno.org)
  • Intracellular signals that result in integrin activation are referred to as 'inside-out' signaling events. (thno.org)
  • The combined chemo-photothermal therapy using E/PCF-NPs for triple-negative breast cancer was evaluated. (dovepress.com)
  • While, the role of sunitinib and inhibitors of mammalian target of rapamycin (mTOR) in breast cancer has to be defined. (biomedcentral.com)
  • Breast Cancer Res. (rush.edu)
  • On the other hand, obesity is associated with a 30-70% increased risk of colon cancer in men [ 2 ]. (biomedcentral.com)