• They are broadly divided in two classes: The germinomatous or seminomatous germ-cell tumors (GGCT, SGCT) include only germinoma and its synonyms dysgerminoma and seminoma. (wikipedia.org)
  • The nongerminomatous or nonseminomatous germ-cell tumors (NGGCT, NSGCT) include all other germ-cell tumors, pure and mixed. (wikipedia.org)
  • Compared with germinomatous tumors, nongerminomatous tumors tend to grow faster, have an earlier mean age at time of diagnosis (around 25 years versus 35 years, in the case of testicular cancers), and have a lower five-year survival rate. (wikipedia.org)
  • They are found in:[citation needed]} head inside the cranium - pineal and suprasellar locations are most commonly reported inside the mouth - a fairly common location for teratoma neck mediastinum - account for 1% to 5% of all germ cell neoplasms pelvis, particularly sacrococcygeal teratoma In females, GCTs account for 30% of ovarian tumors, but only 1 to 3% of ovarian cancers in North America. (wikipedia.org)
  • In younger women, they are more common, thus in patients under the age of 21, 60% of ovarian tumors are of the germ-cell type, and up to one-third are malignant. (wikipedia.org)
  • The present invention relates to compositions and methods for treating cancerous tumors, including naïve, metastatic and recurrent cancers. (justia.com)
  • The following text points out several possibilities and chemical pathways in which "Intume" chlorine dioxide intervention can destroy tumors and prevent proliferation of cancer cells. (justia.com)
  • Cancer cells are rich in polyamines which is necessary for survival and growth of tumors. (justia.com)
  • Teratocarcinoma refers to a germ cell tumor that is a mixture of teratoma with embryonal carcinoma, or with choriocarcinoma, or with both. (wikipedia.org)
  • The observation that one inch of cancerous liver tissue can have more than 100 000 000 mutations and an identical mutation can result in different phenotypes, depending on the environment surrounding that mutation, makes it very unlikely that mutations by themselves are causative of most cancers. (4open-sciences.org)
  • According to the American Cancer Society (ACS), the 5-year relative survival rate differs significantly according to cancer type with higher rates ≥90% for prostate cancer, melanoma, skin and female breast cancer compared to lower rates ≤18% in liver, lung, and pancreatic cancer [ 1 ]. (4open-sciences.org)
  • Targeted therapies specifically target cancer cells while sparing healthy cells, leading to fewer side effects and improved patient outcomes. (patentpc.com)
  • Immunotherapies harness the body's immune system to recognize and destroy cancer cells, offering a novel and effective treatment option. (patentpc.com)
  • ix Capacity of cancer tissue to produce abundant PA likely contributes to cancer cell's higher growth rates.ix ,x High concentrations of PA enhance cancer cells to invade, and is associated with less apoptosis and increased expression of the genes affecting metastasis.ix ,xi The association of increased polyamine synthesis and cancer was first reported in the late 1960s. (justia.com)
  • We speculate that precancerous stem cells (pCSCs) arise during the evolution of carcinomas based on long-term experimental findings, published literature, and the cancer stem cell (CSC) theory, wherein pCSCs exist in precancerous lesions and have characteristics of both CSCs and normal stem cells. (biomedcentral.com)
  • Therefore, investigations on testing and maintaining the integrity of genomic DNA within precancerous stem cells (pCSCs), which are within the framework of the cancer stem cell (CSC) hypothesis, are necessary. (biomedcentral.com)
  • We then focused on two genes previously linked to various cancers, mesothelin and stromelysin-1, which are respectively up-regulated by Wnt-1 and Wnt-5a in C57mg cells. (biomedcentral.com)
  • In their meta-analysis, Kinkel et al compared US, CT, MRI, and fluorodeoxyglucose (FDG) imaging in the detection of liver metastases from colorectal, gastric, and esophageal cancers and concluded that, with an equivalent specificity, FDG positron emission tomography (PET) is the most sensitive noninvasive imaging modality for the diagnosis of liver metastases. (medscape.com)
  • The market for compositions for the treatment and detection of cancer has witnessed significant growth in recent years. (patentpc.com)
  • Compositions for the treatment and detection of cancer play a crucial role in improving patient outcomes and saving lives. (patentpc.com)
  • As a result, there is a pressing need for advanced compositions that can effectively treat and detect cancer at an early stage. (patentpc.com)
  • Compositions such as targeted therapies, immunotherapies, and precision medicine have emerged as promising approaches in the fight against cancer. (patentpc.com)
  • The market for compositions for the treatment and detection of cancer is also driven by increased research and development activities. (patentpc.com)
  • Pharmaceutical and biotechnology companies are investing heavily in developing innovative compositions that can effectively target and treat various types of cancer. (patentpc.com)
  • Furthermore, the growing importance of early cancer detection has contributed to the demand for compositions that can accurately diagnose cancer at its earliest stages. (patentpc.com)
  • Compositions such as liquid biopsies, molecular diagnostics, and imaging techniques have shown great promise in detecting cancer at its earliest stages, enabling timely intervention and treatment. (patentpc.com)
  • The market for compositions for the treatment and detection of cancer is highly competitive, with numerous players vying for market share. (patentpc.com)
  • These companies are constantly striving to develop innovative compositions that can address the unmet needs of cancer patients. (patentpc.com)
  • In conclusion, the market for compositions for the treatment and detection of cancer is witnessing significant growth due to the rising incidence of cancer, advancements in technology, increased research and development activities, and the growing importance of early cancer detection. (patentpc.com)
  • As the global burden of cancer continues to increase, the demand for effective and innovative compositions will only continue to rise. (patentpc.com)
  • Patients with germ-cell cancer often need to be treated with combination chemotherapy for at least three cycles, but female patients with early-stage disease may not require this treatment. (wikipedia.org)
  • The prognosis for GBM is poor despite the availability of many treatments including surgery, radiotherapy, and chemotherapy. (patentpc.com)
  • Interest in targeting polyamine metabolism as a potential strategy for cancer chemotherapy was stimulated in the early 1970s. (justia.com)
  • Wnt ligands are secreted glycoproteins that function in intracellular signaling pathways to regulate a variety of developmental processes including cell growth, cell differentiation, cell polarity, and apoptosis. (biomedcentral.com)
  • In males, GCTs of the testis occur typically after puberty and are malignant (testicular cancer). (wikipedia.org)
  • In general, all patients with malignant GCTs have the same staging surgery that is done for epithelial ovarian cancer. (wikipedia.org)
  • Presently, the likelihood of an oral potentially malignant disorder (OPMD) progressing to oral cancer is determined according to histopathological findings, which are susceptible to inadequate and/or subjective qualitative interpretations [ 5 ]. (biomedcentral.com)
  • With the increasing prevalence of cancer worldwide, there is a growing need for innovative and effective solutions to combat this deadly disease. (patentpc.com)
  • The increasing prevalence of risk factors such as tobacco use, unhealthy diets, physical inactivity, and exposure to carcinogens has contributed to the growing burden of cancer. (patentpc.com)
  • Accurate assessment of the carcinogenic potential of oral mucosal diseases can significantly reduce the prevalence of oral cancer. (biomedcentral.com)
  • Plain chest radiographs are routinely obtained in patients who are suspected of having cancer and are also used in the staging of cancer, but plain abdominal radiography has a limited role in the investigation of liver metastases. (medscape.com)
  • The antibodies can be used to target carcinomas in the brain, skin and bone, as well as cancers of the lungs, esophagus or stomach, liver, gallbladder, pancreas. (patentpc.com)
  • There is a kind of zeitgeist that findings in genetics, namely somatic mutations, are reflexively viewed as being causative for carcinogenesis, although some 80% of all cancers are presently termed "sporadic" (i.e., with no proven cause). (4open-sciences.org)
  • The development of novel therapies and diagnostic tools holds great promise in improving patient outcomes and ultimately eradicating cancer. (patentpc.com)
  • From a "birds-eye" view, it may appear that we have made little progress in eradicating cancer and that outcomes are largely based on the merits, or lack thereof, of any selected therapy " meaning to reach the proposed vision " Imagine a world without cancer " [ 6 ], we need to work much harder to understand the as yet unanswered questions that surround the origins of most cancers. (4open-sciences.org)
  • A vast amount of research exists on the possible molecular mechanisms through which vitamin D affects cancer cell proliferation, cancer progression, angiogenesis, and inflammation. (mdpi.com)
  • While more advanced cancer stages reveal significantly lower survival rates [ 1 ] they may just represent clinical empiricism [ 4 , 5 ] and do not explain the origin of cancer. (4open-sciences.org)
  • Advancements in technology have revolutionized the field of cancer treatment and detection. (patentpc.com)
  • Early detection plays a crucial role in improving survival rates and reducing the burden of cancer. (patentpc.com)
  • Despite success in some cancer survival rates, these numbers differ by race, ethnicity, socioeconomics, health policy, geography, and age so the overall survival numbers ignore the large variations within any given group. (4open-sciences.org)
  • The antibodies disclosed herein can bind certain cancer cell surface. (patentpc.com)
  • We conducted a systematic review of the literature on the effects of vitamin D on ovarian cancer cell. (mdpi.com)
  • We hope that our study will increase attention to pCSC research and lead to the development of novel strategies for the prevention and treatment of oral cancer by identifying pCSC markers. (biomedcentral.com)
  • Epidemiologic evidence indicates that lower circulating vitamin D levels are associated with a higher risk of ovarian cancer and that vitamin D supplementation is associated with decreased cancer mortality. (mdpi.com)
  • Epidemiologically, cancer is an age-related disease which will be a major burden to healthcare worldwide along with neurologic, cardiovascular diseases, and diabetes [ 3 ]. (4open-sciences.org)
  • If the patient has finished having children, the surgery involves complete staging, including salpingoophorectomy on both sides, as well as hysterectomy. (wikipedia.org)
  • This is not an option when the cancer is in both ovaries. (wikipedia.org)
  • The methods of use are not limited to cancer diagnostics and therapies. (patentpc.com)