Cancer chemoprevention by garlic organosulfur compounds. Medical search. Frequent questions

This article reviews current knowledge on cancer chemopreventive effects of a few highly promising dietary constituents, including garlic-derived organosulfides, berry compounds, and cruciferous vegetable-derived isothiocyanates, and serves to illustrate complexity of the signal transduction mechanisms in cancer chemoprevention by these promising bioactive food components. (nih.gov)
Garlic, a common spice used since time immemorial for various purposes, is considered a potential functional food as it exhibits cardioprotection to chemoprevention properties due to the presence of organosulfur constituents in each garlic pod. (phcog.com)

11) When raw garlic cloves are crushed, the compound allicin forms. (wemagazineforwomen.com)
Once consumed, allicin generates multiple compounds that benefit human health. (wemagazineforwomen.com)
12) One hundred forty-six participants took either a daily garlic supplement with 180 mg of allicin or a placebo for 12 weeks. (wemagazineforwomen.com)
13) To get the maximum benefit, be sure to chew raw garlic or buy a garlic supplement with allicin. (wemagazineforwomen.com)
Alliin is not widely studied for its bioactivity as it is an unstable compound which is converted to allicin on mechanical and chemical degradation. (phcog.com)
Garlic produces a chemical called allicin. (supplemented.net)
Allicin also makes garlic smell. (supplemented.net)

2016. Sulforaphane modulates telomerase activity via epigenetic regulation in prostate cancer cell lines. . (oregonstate.edu)
2009. Modulation of histone deacetylase activity by dietary isothiocyanates and allyl sulfides: studies with sulforaphane and garlic organosulfur compounds. . (oregonstate.edu)
2017. Long noncoding RNAs and sulforaphane: a target for chemoprevention and suppression of prostate cancer. . (oregonstate.edu)
2013. HDAC turnover, CtIP acetylation and dysregulated DNA damage signaling in colon cancer cells treated with sulforaphane and related dietary isothiocyanates. . (oregonstate.edu)
2017. A functional pseudogene, NMRAL2P, is regulated by Nrf2 and serves as a coactivator of NQO1 in sulforaphane-treated colon cancer cells. . (oregonstate.edu)
Effects of sulforaphane and 3,3'-diindolylmethane on genome-wide promoter methylation in normal prostate epithelial cells and prostate cancer cells. (oregonstate.edu)
Analysis of autophagic flux in response to sulforaphane in metastatic prostate cancer cells. (oregonstate.edu)
2006. Histone deacetylases as targets for dietary cancer preventive agents: lessons learned with butyrate, diallyl disulfide, and sulforaphane. . (oregonstate.edu)
Food contains chemical compounds, like sulforaphane, that enhance the way that Tamoxifen works. (uniquenutritionsolutions.com)

For instance, anticancer effect of Allium vegetables including garlic is attributed to organosulfur compounds (e.g., diallyl trisulfide). (nih.gov)

2007. Cruciferous vegetables and human cancer risk: epidemiologic evidence and mechanistic basis. . (oregonstate.edu)
Green vegetables (the cruciferous family in particular) contain compounds with anti-cancer properties and substances that protect blood vessels. (drfuhrman.com)
Cruciferous vegetables, which contain phytochemicals, inhibit a wide range of cancer-promoting cellular processes, including angiogenesis (new blood vessel growth), which is needed for tumor growth and fat tissue growth. (drfuhrman.com)
6-9 Eating cruciferous vegetables regularly is associated with decreased risk of breast cancer and has even been shown to increase survival in women after being diagnosed with breast cancer. (drfuhrman.com)

The incidence of colorectal cancer is highest in Western populations. (naturalmedicinejournal.com)
Screening and early diagnosis have profound effects on the prognosis of individuals with colorectal cancer, and recognizing those at high risk may save lives through early detection. (naturalmedicinejournal.com)
In addition, many evidence-based nutritional interventions exist that may reduce the risk of developing colorectal cancer in those at high risk. (naturalmedicinejournal.com)
Colorectal cancer (CRC) is the third most common cancer 1 and the second leading cause of cancer deaths in the United States. (naturalmedicinejournal.com)
While the incidence of colorectal cancer cases directly attributable to these genetic syndromes is small, they are highly penetrant, with a lifetime risk of 100% and 80% of developing colorectal cancers in those with FAP and Lynch syndrome respectively. (naturalmedicinejournal.com)
In addition to genetic syndromes and IBD, established risk factors include age, personal history of adenomas, family history of colorectal cancer, diets high in fat and low in fruit/vegetables, obesity, sedentary lifestyle, smoking, and excessive alcohol intake. (naturalmedicinejournal.com)
Common symptoms of colorectal cancer include alterations in bowel habit, rectal bleeding, weight loss, abdominal pain, obstructive symptoms, and changes in the caliber/shape of stool (See Table I). The general nature and prevalence of benign abdominal complaints make recognizing which patients may have a malignancy very challenging. (naturalmedicinejournal.com)
11 However, there is greater PPV for colorectal cancer when rectal bleeding is accompanied by changes in bowel habits, or when unaccompanied by perianal symptoms. (naturalmedicinejournal.com)
11 The presence of severe anemia in those patients presenting with rectal bleeding also increases the PPV for colorectal cancer in a primary care setting. (naturalmedicinejournal.com)
12 One study from the United Kingdom showed that concomitant signs and symptoms with rectal bleeding doubles the likelihood of a colorectal cancer diagnosis. (naturalmedicinejournal.com)
Hsieh SL, Li JH, Dong CD, Chen CW, Wu CC*. Carnosine suppresses human colorectal cancer cell proliferation by inducing necroptosis and autophagy, and reducing angiogenesis. (nutr-metab-pu.org)
Suppression of carnosine on adhesion and extravasation of human colorectal cancer cells. (nutr-metab-pu.org)
Hsieh SL, Hsieh S, Kuo YH, Wang JJ, Wang JC, Wu CC*. Effects of Panax notoginseng on the metastasis of human colorectal cancer cells. (nutr-metab-pu.org)

2 Overall risk of colon cancer is approximately 5% in the general population without family history, with 92% of colorectal cancers diagnosed after age 50. (naturalmedicinejournal.com)
3 Unfortunately, 20% of those diagnosed with colon cancer are diagnosed in late, less treatment-responsive stages. (naturalmedicinejournal.com)
Those at greatest risk for colon cancer are carriers of 1 of 2 familial genetic disorders, familial adenomatous polyposis (FAP) or hereditary non-polyposis colon cancer (HNPCC), also known as Lynch syndrome. (naturalmedicinejournal.com)
8 The National Cancer Institute (NCI) has created an online risk assessment tool to calculate the risk of colon cancer in patients over 50 years old. (naturalmedicinejournal.com)
The fiber and resistant starch in beans reduce the total number of calories absorbed from beans, 10-11 reduce cholesterol levels, and are converted by healthy gut bacteria into many substances that protect against colon cancer. (drfuhrman.com)

Garlic appears to enhance immune system function by stimulating multiple types of immune cells and modulating immune activity. (wemagazineforwomen.com)
Seventy to eighty percent of cancer patients in chemotherapy experienced side effects such as anemia, the decreased number of white blood cells and/or platelets, oral mucositis, vomiting, diarrhea, hair loss, and disabled generative functions as chemotherapy also affects the rapidly proliferating normal cells. (jcpjournal.org)
To decrease side effects from non-specific cytotoxicity, new drugs, such as targeted agents, are being developed to selectively destroy specific cancer cells. (jcpjournal.org)
Interestingly, unlike cancer chemotherapy drugs, many bioactive food components selectively target cancer cells. (nih.gov)
Molecular basis for selectivity of anticancer bioactive food components towards cancer cells remains elusive, but these agents appear promiscuous and target multiple signal transduction pathways to inhibit cancer cell growth in vitro and in vivo. (nih.gov)
It is impressive to note that alliin content was high in fresh aqueous extract compared to that of dried garlic extract which concludes that the use of garlic from time immemorial is a worthy functional food in its fresh form to combat cancer cells. (phcog.com)
18-21 These vegetables are known for their characteristic (and eye-irritating) organosulfur compounds, which slow tumor growth and kill cancer cells. (drfuhrman.com)
In one fascinating study, women were given flaxseeds daily after being diagnosed with breast cancer and reduced growth and increased death of their tumor cells was found after just 4-5 weeks. (drfuhrman.com)
However, during research, it was discovered that tamoxifen inhibited the growth of ER-positive breast cancer cells. (uniquenutritionsolutions.com)

The quantity of alliin in fresh and dried garlic extract was measured by high-performance liquid chromatography to corroborate the cytotoxicity activity identified by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide assay and acridine orange/ethidium bromide staining. (phcog.com)

Onions, leeks, garlic, shallots, chives, and scallions not only lend great flavor to meals, they have beneficial effects on the cardiovascular and immune systems, as well as anti-diabetic and anti-cancer effects. (drfuhrman.com)

Research over the last three decades has provided convincing evidence to support the premise that diets rich in fruits and vegetables may be protective against the risk of different types of cancers. (nih.gov)
Initial evidence for protective effect of fruits and vegetables against cancer risk came from population-based case-control studies, which prompted intense research aimed at (a) identification of bioactive component(s) responsible for the anticancer effects of fruits and vegetables, (b) elucidation of the mechanisms by which bioactive food components may prevent cancer, and (c) determination of their efficacy for prevention of cancer in animal models. (nih.gov)
Organized by region, the following fruits and vegetables offer record levels of vitamins and high-potency, cancer-healing compounds. (cancerfreewithfood.com)
22-23 These vegetables also contain high concentrations of anti-inflammatory flavonoids--antioxidants that contribute to their anti-cancer properties. (drfuhrman.com)

[i] It is also great for the digestive tract because of compounds it contains that promote gastrointestinal health. (cancerfreewithfood.com)
Eating onions and garlic frequently is associated with reduced risk of digestive cancers. (drfuhrman.com)

4 Hence, regular consumption of anticancer foods that display no or little toxicity to the body and boost efficacy of anti-tumor drugs or stop the development of tolerance would be beneficial in preventing cancer. (jcpjournal.org)
2012. Cancer chemoprevention by dietary chlorophylls: a 12,000-animal dose-dose matrix biomarker and tumor study. . (oregonstate.edu)
Increased expression of the alpha receptor is good, especially when pregnant, but not so much if we have a breast cancer tumor. (uniquenutritionsolutions.com)
Tamoxifen helps balance these two types of cell receptors, thereby reducing the risk of tumor development and cancer. (uniquenutritionsolutions.com)
This is part three of three articles with excerpts from "Tumor Angiogenesis as a Target for Dietary Cancer Prevention" by Dr. William Li. (ppt-health.com)

2012. MicroRNAs, diet, and cancer: new mechanistic insights on the epigenetic actions of phytochemicals. . (oregonstate.edu)
7 Up to 70% of colorectal cancers may be due to preventable habits involving diet and lifestyle. (naturalmedicinejournal.com)
Staying slim and active, focusing on healthful natural foods, and avoiding the disease-causing foods of the Standard American diet are strategies women can use to win the war on breast cancer. (drfuhrman.com)
Likewise, Japanese men in Hawaii who consume a high soy diet have low mortality from prostate cancer. (ppt-health.com)

Other compounds like epigallocatechin gallate or EGCG, found in green tea, actually increase the bioavailability or absorption of Tamoxifen. (uniquenutritionsolutions.com)

Historically, breast cancer incidence rates have been 4 to 7 times higher among white women in the US compared to in women in China or Japan. (ppt-health.com)

Currently, the treatment of cancer patients in the medical field consists mainly of surgery, radiation therapy, and chemotherapy. (jcpjournal.org)
Resting energy expenditure and body mass changes in women during adjuvant chemotherapy for breast cancer. (lifeovercancer.com)
Harvie MN, Campbell IT, Baildam A, Howell A. Energy balance in early breast cancer patients receiving adjuvant chemotherapy. (lifeovercancer.com)
Reduced rates of metabolism and decreased physical activity in breast cancer patients receiving adjuvant chemotherapy. (lifeovercancer.com)

Most of us consume garlic regularly in the form of garlic powder or cooked garlic in savory dishes. (wemagazineforwomen.com)
Dairy products like milk, Greek yogurt, skyr (Icelandic yogurt), cottage cheese and cheese, not to mention the protein powders whey and casein, aren't just the most anabolic proteins you can consume, they're also known (and documented by piles of research) to help reduce your risk of cancer. (jimstoppani.com)
People who consume high amounts of garlic over about an 8-week period seem to have a reduced number of tick bites. (supplemented.net)

Seventeen potentially bioactive peptides are derived from the protein in quinoa, which scientists believe might be utilized as new nutraceuticals with the aim of reducing diseases, like cancer, which are associated with oxidative stress. (cancerfreewithfood.com)

Taking a specific garlic powder supplement (Allicor, INAT-Farma) twice daily for 24 months seems to reduce how much hardening of the arteries progresses. (supplemented.net)
Also, 150 mg of a specific garlic supplement (Allicor, INAT-Farma) twice daily for 24 months has been used. (supplemented.net)

It's unclear if garlic reduces post-meal blood sugar levels or HbA1c levels. (supplemented.net)

Over the trial period, the participants who took garlic experienced significantly fewer cold episodes than those who took the placebo. (wemagazineforwomen.com)

In foods and beverages, fresh garlic, garlic powder, and garlic oil are used to add flavor. (supplemented.net)
A 300 mg garlic powder tablet (Kwai, Lichtwer Pharma), taken as a single dose or three times daily for up to 4 years, has been used. (supplemented.net)

Additionally, the Health Professionals Follow-up Study identified a protective effect for prostate cancer with a 36% risk reduction in men drinking 2-4 glasses of red wine per week. (ppt-health.com)

2006. Xenobiotic metabolism relevance to cancer. . (oregonstate.edu)
In addition, these top 5 foods help promote healthy estrogen metabolism, reducing your risk for breast cancer. (uniquenutritionsolutions.com)

Despite convincing observational and experimental evidence, however, limited effort has been directed towards clinical investigations to determine efficacy of bioactive food components for prevention of human cancers. (nih.gov)

Early clinical research suggests that taking garlic extract supplements might reduce the risk of prostate cancer or reduce symptoms associated with prostate cancer. (supplemented.net)
Clinical aspects of nutrition in advanced cancer. (lifeovercancer.com)

When discussing men's health issues, we tend to hear the same diseases brought up time and again: prostate cancer, testicular cancer, heart disease, high blood pressure, to name just a handful. (jimstoppani.com)

When people ate food provided by the Earth without tampering with it, there were fewer cases of cancer. (cancerfreewithfood.com)

2007. Frontiers in polyphenols and cancer prevention. . (oregonstate.edu)

Researchers from the United Kingdom published a study in Advances in Therapy that examined the effect of garlic on the common cold. (wemagazineforwomen.com)
They also noted that while there may be occasional reports about the probable causative effect of milk consumption on some types of cancer, it must be remembered that not only are there far more published studies showing a beneficial impact from dairy consumption, there's ample convincing evidence through thousands of years of consumption of dairy products that shows their definitive impact on health maintenance, survival and longevity. (jimstoppani.com)
Garlic seems to reduce this effect. (supplemented.net)
Such antibacterial activity may be due to the synergistic effect of the plant compounds acting as capping agents [ 6 ] . (encyclopedia.pub)

Plus, mushrooms are unique in that they contain aromatase inhibitors--compounds that can block the production of estrogen. (drfuhrman.com)
Aromatase inhibitors are thought to be largely responsible for mushrooms' preventive effects against breast cancer. (drfuhrman.com)

Garlic is most commonly used for conditions related to the heart and blood system. (supplemented.net)

Thus, consumption of plant-derived natural foods to prevent cancer with few side effects and toxicity is crucial. (jcpjournal.org)
In my opinion, it's more powerful to eat cancer-healing foods farmed in your local area. (cancerfreewithfood.com)
Source out what cancer fighting foods are grown locally to you because they do strengthen the immune system. (cancerfreewithfood.com)
[i] "Five Foods That May Help Lower Your Cancer Risk," MD Anderson Cancer Center. (cancerfreewithfood.com)
As I describe in my book Super Immunity , G-BOMBS (Greens, Beans, Onions, Mushrooms, Berries and Seeds) are the foods with the most powerful immune-boosting and anti-cancer effects. (drfuhrman.com)
Berries and pomegranate are anti-angiogenic foods, and have anti-inflammatory effects that may protect against cancer and other chronic diseases. (drfuhrman.com)

Chemoprevention is defined as the use of nontoxic or relatively safe chemical substances, such as vitamins, plant extracts, and pharmaceuticals to prevent cancer. (jcpjournal.org)
An ancient grain, quinoa is a whole food that is naturally loaded with fiber, vitamins, minerals, and plant compounds that reduce our cancer risk! (cancerfreewithfood.com)

Numerous studies confirm that dairy consumption is associated with a reduced risk of colorectal, breast, bladder, ovarian and prostate cancer. (jimstoppani.com)
You may have heard the complete opposite from scaremongers citing studies that suggest that eating dairy products actually increases the risk of cancer. (jimstoppani.com)
Scientific studies show there are powerful preventive lifestyle measures to protect against breast cancer. (drfuhrman.com)
A recent analysis of ten scientific studies has shown that the higher your fiber intake, the lower your risk of breast cancer . (drfuhrman.com)
In fact, among women with breast cancer, soy food consumption has now been shown in numerous, large-scale studies to be significantly associated with decreased risk of death and recurrence, regardless of estrogen receptor status or tamoxifen use. (ppt-health.com)
Both preclinical and epidemiological studies suggest that omega-3 PUFAs are effective cancer preventative agents. (ppt-health.com)

And because most men would never imagine that they could get breast cancer, they wait far too long to seek the medical attention they need when early symptoms arise. (jimstoppani.com)
The best thing you can do, in addition to watching yourself for any signs or symptoms, is talk about male breast cancer with your friends. (jimstoppani.com)
Interestingly, a recent review of 248 published papers found that the only symptoms with positive predictive value (PPV) for colorectal cancers were bleeding and weight loss. (naturalmedicinejournal.com)

Inflammatory bowel diseases (IBD), including Crohn's disease and ulcerative colitis, also raise the risk of colorectal cancers considerably. (naturalmedicinejournal.com)

3) Researchers have found that compounds within Andrographis enhance immune function. (wemagazineforwomen.com)

In the Health Professionals Follow-Up Study of over 51,000 men, the highest quintile of lycopene consumption was found to have a 15% risk reduction for developing prostate cancer compared to men in the lowest quintile. (ppt-health.com)

Duffy C, Perez K, Partridge A. Implications of phytoestrogen intake for breast cancer. (lifeovercancer.com)
Point-counterpoint: soy intake for breast cancer patients. (lifeovercancer.com)
94) Intake of omega-3 PUFAs from seafood has been associated with a decreased risk for certain cancers, including pancreatic, colon, breast, and prostate cancer. (ppt-health.com)

The efficacy of nutritional assessment and support in cancer surgery. (lifeovercancer.com)

Berries' plentiful antioxidant content helps reduce blood pressure and inflammation, prevent DNA damage that leads to cancer, protect the brain against oxidative damage and stimulate the body's own antioxidant enzymes. (drfuhrman.com)
substances that inhibit the production of estrogen, which can reduce breast cancer risk. (drfuhrman.com)
Garlic seems to modestly reduce pre-meal blood sugar levels in people with or without diabetes. (supplemented.net)
While not all research agrees, the most reliable evidence shows that taking garlic may reduce total cholesterol and low-density lipoprotein (LDL, "bad" cholesterol) in people with high cholesterol levels. (supplemented.net)
Taking garlic by mouth seems to reduce systolic blood pressure (the top number) by about 7-9 mmHg and diastolic blood pressure (the bottom number) by about 4-6 mmHg in people with high blood pressure. (supplemented.net)
Whereas tamoxifen can reduce your risk for breast cancer, especially if you are high risk, it does have negative side effects. (uniquenutritionsolutions.com)
What is Tamoxifen, and How Does It Reduce Breast Cancer Risk? (uniquenutritionsolutions.com)
By being a SERM, Tamoxifen can reduce breast cancer risk while preserving estrogen's positive actions throughout the body. (uniquenutritionsolutions.com)

Some seeds - sesame, chia and flax in particular - are rich in lignans, plant estrogens that protect against breast cancer. (drfuhrman.com)

While garlic may have some benefit for preventing the common cold, there is no good evidence to support using it for COVID-19. (supplemented.net)

Women aren't the only ones who get breast cancer. (jimstoppani.com)
But there's one other disease that's almost never brought up that I'd like to call your attention to: male breast cancer. (jimstoppani.com)
It may seem like an oxymoron, but it's true: Men can get breast cancer. (jimstoppani.com)
Male breast cancer accounts for only about 1% of all breast cancers. (jimstoppani.com)
It's estimated that every year there are approximately 2,000 new cases of male breast cancer and 400 men will die each year from it. (jimstoppani.com)
This pales in comparison to the roughly 40,000 women who die from breast cancer each year. (jimstoppani.com)
However, the small number of men who are diagnosed with and die from breast cancer is problematic due to the fact that no one is talking about it. (jimstoppani.com)
These are some of the reasons I'm taking this time to help raise awareness for male breast cancer. (jimstoppani.com)
My goal is to make more men realize that this is a reality and to educate them so that any man who may feel a lump in his chest or any other signs of breast cancer gets the immediate attention he needs. (jimstoppani.com)
Only when more men start talking about breast cancer can others find support from those who have also suffered from it. (jimstoppani.com)
If a man is diagnosed with breast cancer at an early stage, he has a very good chance for survival. (jimstoppani.com)
They're either uninformed that breast cancer is even a possibility or, as I mentioned earlier, are simply embarrassed by it. (jimstoppani.com)
For this reason, many cases of male breast cancer are diagnosed when the disease is more advanced. (jimstoppani.com)
Also, if you can, be sure to donate to the National Breast Cancer Foundation ( www.nationalbreastcancer.org ) and the Male Breast Cancer Foundation in Memory of Mr. John W. Nick ( www.malebreastcancer.org ). (jimstoppani.com)
Every woman can personally fight against breast cancer. (drfuhrman.com)
Women must know they are not defenseless in the war to end breast cancer. (drfuhrman.com)
In a recent Chinese study, women who ate at least 10 grams of fresh mushrooms each day (which equates to about one button mushroom per day) had a 64 percent decreased risk of breast cancer! (drfuhrman.com)
Tamoxifen is a drug often used to treat women who have had estrogen receptor-positive (ER+) breast cancer or are at high risk for breast cancer. (uniquenutritionsolutions.com)
It also helps create a healthy balance between the alpha and beta estrogen receptors, reducing breast cancer risk. (uniquenutritionsolutions.com)
Breast Cancer Res Treat. (lifeovercancer.com)
Addressing the soy and breast cancer relationship: review, commentary, and workshop proceedings. (lifeovercancer.com)
81) However, when Asian women migrate to the US, their breast cancer risk rises over several generations to reach that of US white women. (ppt-health.com)

And taking garlic doesn't help increase high-density lipoprotein (HDL, "good" cholesterol) or lower levels of other blood fats called triglycerides. (supplemented.net)

27 All types of mushrooms have anti-cancer properties. (drfuhrman.com)

Organisms5

Diseases1

Chemicals and Drugs10

Analytical, Diagnostic and Therapeutic Techniques and Equipment1

Technology, Industry, Agriculture2

Constituents2

Allicin7

Sulforaphane9

Diallyl1

Cruciferous4

Colorectal cancer13

Colon cancer5

Cells9

Dried garlic extract1

Chives1

Vegetables4

Digestive2

Tumor5

Diet4

EGCG1

Incidence1

Chemotherapy4

Consume3

Oxidative stress1

Supplement2

Reduces1

Placebo1

Powder2

Protective effect1

Metabolism2

Human1

Clinical2

Testicular1

Fewer1

Polyphenols1

Effect4

Inhibitors2

Commonly1

Foods6

Vitamins2

Studies6

Symptoms3

Diseases1

Researchers1

Consumption1

Intake3

Efficacy1

Reduce8

Plant1

Common1

Breast cancer22

High1

Properties1