• 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT)-test was used to observe the proliferation of human breast cancer MCF-7 and MDA-MB-231 cells induced on VALD-3. (researchsquare.com)
  • The current study demonstrated that PD markedly inhibited PAC cell proliferation and triggered their apoptosis. (biomedcentral.com)
  • These agents inhibit cell growth and proliferation. (medscape.com)
  • Cisplatin inhibits DNA synthesis and, therefore, cell proliferation, by causing DNA cross-linking and denaturation of the double helix. (medscape.com)
  • The drug leads to single-stranded and double-stranded DNA breaks that arrest cellular proliferation in the late S or early G2 phase of cell cycle. (medscape.com)
  • Coculture of CAFs with PDAC cells revealed that most of the glucose was taken up by the tumor cells and that CAFs consumed lactate via monocarboxylate transporter 1 to enhance proliferation through the TCA cycle. (jci.org)
  • Effects of Ganoderma lucidum spores on HepG2 cells proliferation and growth cycle. (springer.com)
  • In addition, AKT/mTOR signaling and MAPK signaling were inhibited by JIB extract to suppress melanoma cell growth and proliferation. (medsci.org)
  • The results demonstrated that JIB extract combined with cisplatin enhanced the inhibition of cell growth, proliferation, and survival through the obstruction of cell cycle progression and AKT/mTOR and MAPK signaling as well as the induction of cell apoptosis. (medsci.org)
  • To find the mechanism that exerts a suppressive proliferation effect on P. paniceum , we determined the DNA fragmentation and cell cycle distribution. (wjon.org)
  • P. paniceum did not possess any toxicity (cytotoxic and mutagenic) but has the potential for anticancer activity against human colorectal cells by increasing apoptosis, which leads to the suppression of cell proliferation. (wjon.org)
  • Previous studies have demonstrated that glycolysis inhibitors reduce the proliferation of non‑small cell lung cancer (NSCLC) cells by interfering with the aerobic glycolytic pathway. (spandidos-publications.com)
  • Methods used to study the cytotoxic effects include cytotoxicity assay, double staining cell morphological analysis, cell cycle analysis, apoptosis test and cell proliferation assay. (upm.edu.my)
  • Related to its effect on other reported cancer cells, Cuc B could considerably inhibit A549 cells proliferation and development inside a dose- and time- dependent manner. (achrinhibitor.com)
  • Although low concentrations of Cuc B showed no important impact on A549 cell proliferation right after 24 h therapy, prolonged treatment significantly inhibited cancer cells proliferation and colony formation clearly demonstrating that Cuc B is often a potent cytotoxic compound. (achrinhibitor.com)
  • Potential synergistic effects of various combinations including these compounds were tested by measuring cancer cell proliferation and apoptosis. (frontiersin.org)
  • By contrast, the combination of UHRF1 depletion and histone deacetylase (HDAC) inhibition reactivated the silenced genes and strongly suppressed CRC cell proliferation. (biomedcentral.com)
  • Their antitumor activities include inhibition of tumor cell proliferation, induction of tumor cell apoptosis and tumor angiogenesis, modulation of host immune responses, anti-inflammatory and anti-oxidative properties, and protective autophagy. (baituxiao.com)
  • Astragalus polysaccharides (APS) have been shown to regulate the immune function by enhancing the immune organ index, promoting the proliferation of immune cells, stimulating the release of cytokines, and affecting the secretion of immunoglobulin (Ig) and conduction of immune signals. (baituxiao.com)
  • Sirtuins are NAD + -dependent histone deacetylases regulating important metabolic pathways in prokaryotes and eukaryotes and are involved in many biological processes such as cell survival, senescence, proliferation, apoptosis, DNA repair, cell metabolism, and caloric restriction. (biomedcentral.com)
  • Finally, we determined that knockdown of LIPT1 gene expression inhibited proliferation and invasion of hepatoma cells. (biomedcentral.com)
  • In addition, we verified that LIPT1 may promote proliferation, invasion and migration of LIHC cells. (biomedcentral.com)
  • The proliferation of effector T cells such as cytotoxic T cells and the production of cytokines are highly dependent on glycolysis, and therefore become inactive under conditions of low glucose levels and high lactic acid concentrations. (medicaltrend.org)
  • Adjuvant chemotherapy has become the main treatment for breast cancer in China, and about 81.4% of patients with invasive breast cancer begin chemotherapy treatment [5]. (researchsquare.com)
  • Most efforts directed to tame Cancer such as radiotherapy or chemotherapy, all came at a cost of severe side effects. (bvsalud.org)
  • Cancer chemotherapy is based on an understanding of tumor cell growth and how drugs affect it. (medscape.com)
  • This difference allows healthy cells to recover from chemotherapy more quickly than do malignant cells, and this is the rationale for current cyclic dosage schedules. (medscape.com)
  • Because most tumors are deficient in one or more aspects of the function of the p53 tumor suppressor, either as a consequence of mutations within p53, or impairment of upstream and downstream modulators of p53 activity 19 , targeting MK2 has the potential to selectively enhance tumor cell killing without increasing the genotoxic effects of chemotherapy on normal p53-wild type tissues. (nature.com)
  • Platinum-based chemotherapy is still an effective treatment for ovarian cancer in spite of severe side effects and development of resistance associated with its use [ 10 ]. (biomedcentral.com)
  • In order to mitigate the side effects and resistance resulting from cisplatin-based chemotherapy, it is essential to investigate new drugs which are non-toxic and work in alternative/similar pathways to cisplatin, thus providing additional therapeutic options in ovarian cancer. (biomedcentral.com)
  • According to the stage of cancer and the degree of the complication, current treatment methods rely on the success of chemotherapy either alone or combined with surgical resection or radiation therapy. (frontiersin.org)
  • 9. When cancer is treated with surgery followed by chemotherapy it is referred to as adjuvant therapy. (studylib.net)
  • Cancer treatment to relive symptoms of advanced disease is referred to as palliative chemotherapy. (studylib.net)
  • Chemotherapy is one of the most important aspects of cancer treatment, although no ideal chemotherapeutic drug has yet to be developed[ 3 ]. (ijpsonline.com)
  • Leukemia cells in patients are intrinsically resistant to standard chemotherapy, and resistance development in leukemia cells toward drugs results in treatment failure[ 4 , 5 ]. (ijpsonline.com)
  • BT-ON013 trade name] treatment should only be initiated by a health care provider experienced in the administration of cytotoxic chemotherapy (see section 4.4), and should be administered by a health care provider only. (who.int)
  • This study is the first to show that VALD-3 induces apoptosis and cell cycle arrest in human breast cancer cells by suppressing Wnt/β-catenin signaling, indicating that it could be a potential drug for the treatment of breast cancer. (researchsquare.com)
  • Induction of apoptosis and cell cycle arrest, important mechanisms for cancer therapy, are stimulated by resveratrol through different mechanisms, e.g., activation of p53 and modulation of cell cycle proteins. (lacienciadelvino.com)
  • Vanillin also induced apoptosis and cell cycle arrest. (upm.edu.my)
  • Studies of the inhibitory mechanism revealed that ACPS-1 induced apoptosis and cell cycle arrest (cells remained in G2/M phase) through blocking of topoisomerase I/tyrosyl-DNA phosphodiesterase I (TOP1/TDP1)-mediated DNA repair pathway. (tonicology.com)
  • This review discusses the various forms of polymeric and non-polymeric nanocarriers (NC) and the encapsulation of TQ for increasing oral bioavailability and enhanced in vitro and in vivo efficacy of TQ-combined treatment with different chemotherapeutic agents against various breast cancer cell lines. (bvsalud.org)
  • Although valuable progress has been made in the treatment of NSCLC in previous years, the high metastasis rate, post-operative recurrence rate and resistance to chemotherapeutic drugs in lung cancer have led to unsatisfactory outcomes ( 4 , 5 ). (spandidos-publications.com)
  • The cytotoxic effects of resveratrol on healthy cells can be neglected, and, as several pathways leading to chemotherapeutic effects are activated by resveratrol, chemoresistance-inducing mutations in cancer cells can be overcome. (lacienciadelvino.com)
  • Adjuvant treatment for breast cancer involves radiation therapy and a variety of chemotherapeutic and biologic agents. (medscape.com)
  • Although, non-psychoactive cannabidiol (CBD) and cannabigerol (CBG) display antineoplastic effects by repressing tumor growth and angiogenesis both in cell line and animal models, their use as chemotherapeutic agents is awaiting further investigation. (frontiersin.org)
  • 4. Pharmaceuticals used to destroy cancer cells are called anticancer, chemotherapeutic, antineoplastic, or cytotoxic 5. (studylib.net)
  • Here in this study, we screened a panel of chemotherapeutic agents for their possible antitumor activity in high-grade meningioma and discovered that high-grade meningioma cells show a preferential sensitivity to antimetabolites, in particular, to gemcitabine. (oncotarget.com)
  • However, the applicability of such traditional chemotherapeutic approaches is primarily limited due to acquired Multi-Drug Resistance (MDR) in cells, which is acquired through the production of anti-apoptotic cascades and the overexpression of cell membrane-based drug efflux pumps, such as P-glycoprotein, for self-defense. (ijpsonline.com)
  • Artificially increased levels of myosin contractility were also shown to induce blebbing in cells. (wikipedia.org)
  • Some viruses, such as the poxvirus Vaccinia, have been shown to induce blebbing in cells as they bind to surface proteins. (wikipedia.org)
  • Ganoderic acid Mf and S induce mitochondria mediated apoptosis in human cervical carcinoma HeLa cells. (springer.com)
  • In conclusion, vanillin could induce cytotoxic effects on colorectal cancer cells. (upm.edu.my)
  • Cancer cells are characterized by dual DNA methylation-related changes: global hypomethylation, which can induce chromosomal instability and oncogene activation, and regional hypermethylation, which is associated with transcriptional silencing. (biomedcentral.com)
  • Our results suggest that lcn2 acts in an autocrine manner to induce cell death sensitization and morphological changes in astrocytes under inflammatory conditions and that these phenotypic changes may be the basis of reactive astrocytosis in vivo . (jneurosci.org)
  • indicated that S-1 is more effective on HeLa than PNT1-A. S-1 was able to induce apoptosis of cervical malignancy cells and is a possible candidate for future anticancer studies. (euromed2016.com)
  • The same LDH inhibitors can reduce ATP levels and induce oxidative stress and cell death in cancer. (medicaltrend.org)
  • Modulating the intracellular glutathione level by pre-treating the cells with either BSO (buthionine- Sulfoximine) or glutathione significantly influenced the potential of Cr(VI) to induce expression of the HO-1 gene. (cdc.gov)
  • In this study, we aimed to assess the neoplastic-like transformation potential of two forms of CNC derived from wood (powder and gel) in human pulmonary epithelial cells (BEAS-2B) in comparison to fibrous tremolite (TF), known to induce lung cancer. (cdc.gov)
  • The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
  • We discuss TQ's cytotoxic effects for breast cancer treatment with a deep look at the relevant stimulatory or inhibitory signaling pathways. (bvsalud.org)
  • However, in recent years, there has been increasing evidence that metformin exerts its anticancer effects through the inhibition of oxidative phosphorylation (OXPHOS) of tumor cell mitochondria, and metabolic pathways based on metformin targeting have only recently become the focus of intensive research. (spandidos-publications.com)
  • Another mechanism is up-regulation of pathways that inhibits cell apoptosis. (oncologynurseadvisor.com)
  • Inducing cell cycle arrest by cucurbitacins has been B7-2/CD86 Inhibitors targets properly Methyl-PEG3-Ald custom synthesis established while the detailed mechanisms and pathways are largely to become clear. (achrinhibitor.com)
  • Antrolone, a Novel Benzoid Derived from Antrodia cinnamomea, Inhibits the LPS-Induced Inflammatory Response in RAW264.7 Macrophage Cells by Balancing the NF-[Formula: see text]B and Nrf2 Pathways. (tonicology.com)
  • Previously, we exhibited the novel synthesised S-1 attenuated apoptotic, cytotoxic, cell cycle pathways and oxidative stress, therefore, S-1 may have an anti-cancer potential in cervical carcinoma. (euromed2016.com)
  • The following introduces some metabolic pathways regulated by high lactate levels, which are related to the occurrence and development of chronic inflammatory diseases and cancer. (medicaltrend.org)
  • My laboratory is interested in targeting metabolic and molecular pathways in cancer and cancer stem cells by using preclinical cancer models and computer-aided drug discovery approach. (edu.in)
  • The regulation of the stem cell-like properties by several important signaling pathways have been found to endow the tumor cells with an increased level of tumorigenicity, chemoresistance, and metastatic ability. (molcells.org)
  • We demonstrated that CDBPA significantly reduced cell viability and induced apoptosis via the extrinsic and the intrinsic apoptotic pathways of Burkitts lymphoma cells without causing cell cycle arrest but reduction of the various phases. (longdom.org)
  • A polysaccharide from Antrodia cinnamomea mycelia exerts antitumor activity through blocking of TOP1/TDP1-mediated DNA repair pathway. (tonicology.com)
  • The antitumor activity of S-1 in HeLa cells and the main components of the mechanism underlying this impact were investigated. (euromed2016.com)
  • Together, our data demonstrate that gemcitabine exerts potent antitumor activity against high-grade meningioma through cytostatic and cytotoxic mechanisms. (oncotarget.com)
  • AuNPL exerted their cytotoxic activity against HeLa cells through accumulation of the cells in the subG1 phase of the cell cycle, inducing the apoptotic cell death mediated by the activation of caspase-3 − 8, and − 9. (ac.rs)
  • In vitro , gemcitabine inhibited the growth of high-grade meningioma cells effectively by inducing S-phase arrest and apoptotic cell death. (oncotarget.com)
  • Histological analysis indicated that systemic gemcitabine blocks cell cycle progression and promotes apoptotic cell death in tumor cells in vivo . (oncotarget.com)
  • CDBPA exerted a strong apoptotic cell death. (longdom.org)
  • A cell cycle arrest in early S-phase and in G 0 /G 1 -phase was also found after exposure to cisplatin and sunitinib malate, in isolation, respectively. (hindawi.com)
  • Flow cytometry analysis showed that VALD-3 triggered cell cycle arrest and induced apoptosis of breast cancer cells. (researchsquare.com)
  • Our results demonstrate that Pulsatillae chinensis and particularly its bioactive ingredient β-peltatin suppress PAC by triggering cell cycle arrest at G2/M phase and apoptosis. (biomedcentral.com)
  • Therefore, compared to normal p53-proficient cells, p53-defective cells are more reliant on MK2 activity, which drives an alternative cell cycle checkpoint pathway that stabilizes the CKI inhibitors p27 Kip1 and Gadd45α in order to maintain G 1 /S and G 2 /M arrest after certain types of DNA damage 16 , 18 . (nature.com)
  • JIB extract induced cell cycle arrest at the G 0 /G 1 phase and decreased cyclin and cdk protein expressions. (medsci.org)
  • Different concentrations of vanillin showed arrest of cell cycle at different checkpoints. (upm.edu.my)
  • However, the expressions of a few xenobiotic metabolism, cell cycle arrest and apoptosis genes were up-regulated by 5 % ethanol injection. (upm.edu.my)
  • The colon gene expression analysis showed that vanillin could enhance recombinational repair and mismatch repair, arrest cell at cell cycle checkpoints, increase the expression of tumour suppressor gene, colorectal cancer biomarker and proto-oncogene. (upm.edu.my)
  • O additional establish the role of ATM in Cuc B-mediated G2/M phase arrest, transiently transfect A549 cells with ATM siRNA was performed. (achrinhibitor.com)
  • Cuc B, one of many extensively investigated cucurbitacins, lead to diverse phase cell cycle arrest in diverse cancer cells. (achrinhibitor.com)
  • Previous data suggested that Cuc B triggered cell cycle arrest by blocking the STAT3 signaling pathway, which resulted in reduced expression of downstream targets, like Cyclin B1, Cyclin A [402]. (achrinhibitor.com)
  • In SW480 cells, Cuc B induced G2 arrest and apoptosis by means of a STAT3-independent but ROS-dependent mechanism [14]. (achrinhibitor.com)
  • Within this study, we showed that Cuc B induced G2/M arrest inside a ROS dependent manner without having affecting STAT3 in A549 cells: Cuc B induced ROSmediated DNA harm, which activated G2/M phase checkpoint through ATM-activated Chk1-Cdc25C-Cdk1 and -p53-14-3-3-s cascades. (achrinhibitor.com)
  • Activation of STAT3 signaling could up-regulate Cyclin B1, c-Myc, Bcl-x and regulating cell growth and survival.Chk1 knockdown reversed Cuc B induced G2/M phase arrestTo dissect the downstream effector in Cuc B mediated G2/M phase arrest, the part of Chk1 was examined with Chk1 siRNA. (achrinhibitor.com)
  • Comparable to that of ATM siRNA, Cuc B- induced G2/M arrest in A549 cells was substantially decreased by Chk1 siRNA therapy (Fig. 5A, 5B). (achrinhibitor.com)
  • BL cells and normal fibroblasts were exposed to CDBPA for cytotoxicity screening by XTT assay, followed by cell cycle arrest, determination of apoptosis using Flow Cytometry and by annexin V/FITC/PI assay. (longdom.org)
  • In this study, we investigated the cytotoxic and apoptotic effects of VALD-3, a Schiff base ligand synthesized from o-vanillin derivatives, on human breast cancer cells and the possible underlying mechanisms. (researchsquare.com)
  • In order to explore the underlying mechanisms, we performed tests to assess cell migration and motility, apoptosis, expression of glucose transporter 1 and proapoptotic proteins. (oncotarget.com)
  • However, the bioactive ingredients and mechanisms underlying its anti-cancer effect remains unclear. (biomedcentral.com)
  • JAHA's lethal effect was found linked to perturbations of cell cycle, mitochondrial activity, signal transduction, and autophagy mechanisms. (unipa.it)
  • however, mechanisms through which these bioactive compounds act on epithelial cells have not been identified. (biorxiv.org)
  • Moreover, CAR-T cells are vulnerable to immunosuppressive mechanisms. (nature.com)
  • In conclusion, prostate cancer cells have resistance mechanisms to overcome cytotoxic therapies such as docetaxel and cabazitaxel. (oncologynurseadvisor.com)
  • Hence, understanding known mechanisms could be a start in coming up with novel therapies to combat resistant prostate cancer cells. (oncologynurseadvisor.com)
  • In order to better understand the molecular mechanisms responsible for the dermal toxicity of chromium , differential gene expression profiles of human skin fibroblasts exposed to a cytotoxic concentration of hexavalent potassium dichromate [Cr(VI)] were studied. (cdc.gov)
  • Polyphenols (PPs) exert preventive activity against infectious and degenerative diseases and may also help prevent oral diseases via various mechanisms 58 . (bvsalud.org)
  • Gemcitabine plus cisplatin exert comparable activity and a lower toxicity profile when compared to the methotrexate, vinblastine, doxorubicin, and cisplatin (MVAC) regimen [ 6 ]. (hindawi.com)
  • By xenografting human breast cancer cells into nude mice, we found that VALD-3 significantly suppressed tumor cell growth while showing low toxicity against major organs. (researchsquare.com)
  • Therefore, it is imperative to develop new low-cost drugs with low toxicity to treat or prevent breast cancer. (researchsquare.com)
  • Doxorubicin's maximum toxicity occurs during the S phase of cell cycle. (medscape.com)
  • Given the vast differences in metabolism between healthy and tumor cells, there is hope that selective targeting of tumor metabolism may be achieved while limiting toxicity to healthy tissue. (spandidos-publications.com)
  • It is also responsible for inhibition of vascular endothelial growth factors receptors, plateletderived growth factor receptors, and stem cell factor receptor [ 8 , 9 ]. (hindawi.com)
  • SL originally described a relationship between two genes, where alteration of either gene alone results in viable cells, but alteration (mutation, loss, or inhibition) of both genes simultaneously was lethal. (nature.com)
  • Inherited resistance is noted in prostate cancer cells that do not express BCL2, indicating that taxanes' mechanism of action relies at least partly on BCL2 inhibition. (oncologynurseadvisor.com)
  • The combination of UHRF1 depletion and HDAC inhibition also induced marked changes in the gene expression profiles such that cell cycle-related genes were strikingly downregulated. (biomedcentral.com)
  • Another study found that extracts of Astragalus membranaceus overcome tumor immune tolerance by inhibition of tumor programmed cell death protein ligand-1 expression. (baituxiao.com)
  • Chang HL, Kuo YH, Wu LH, Chang CM, Cheng KJ, Tyan YC, Lee CH. The extracts of Astragalus membranaceus overcome tumor immune tolerance by inhibition of tumor programmed cell death protein ligand-1 expression. (baituxiao.com)
  • In the NCI test model, in contrast to conventional cytostatic preparations which caused the growth inhibition only in some cancer cell lines, like thiotepa inhibited the growth of MLI-09 (non-small lung cancer) and UOK-57LN (renal cancer), NSC631570 killed all 60 tested cancer cell lines (190), which represent the eight important human tumours, including the cell lines which were resistant to the strongest cytostatic drug at the time, cisplatin. (ukrin.com)
  • In order to achieve 50% growth inhibition a tenfold concentration of NSC 631570 had to be administered to normal endothelial cells in comparison to a human osteosarcoma cell line. (ukrin.com)
  • particularly, the effect of miR-195-5p modulation seemed to affect cell cycle, while miR-107 seemed to be implicated in the inhibition of cells migration. (biomedcentral.com)
  • Effects of triterpenes from Ganoderma lucidum on protein expression profile of HeLa cells. (springer.com)
  • Novel luteolin capped gold nanoparticles (AuNPL) were synthesized and their anticancer effect towards human cervical adenocarcinoma HeLa cells was investigated in vitro. (ac.rs)
  • AuNPL cytotoxicity against HeLa, human malignant melanoma A375, and normal human keratinocytes HaCaT cells was tested by MTT cell survival assay, and their IC50 values were determined. (ac.rs)
  • n HeLa cells were demonstrated by flow cytometry. (ac.rs)
  • The selectivity in the cytotoxic action of AuNPL on HeLa and A375 cancer cells compared with their cytotoxicity on normal keratinocytes HaCaT was observed. (ac.rs)
  • Additionally, Cuc B brought on phosphorylation of your Chk1 downstream effector Cdc25C on Ser-216 and Cdk1 on Tyr15 had been also inhibited (Fig. 5C).Cuc B induced ROS generation and didn't influence STAT3 phosphorylationRecent research have shown that Cuc B induced intracellular ROS formation in HeLa, SW480, and B16F10 cells [14,15,39]. (achrinhibitor.com)
  • ACPS-1 displayed strong in vitro growth-inhibitory effects on several human and mouse cancer cell lines (HeLa, A431, H22 and S180), and were not cytotoxic to normal mouse spleen cells. (tonicology.com)
  • Tests on human cervical carcinoma cells HeLa, squamous cell carcinoma WHCO5 and normal equine lung cell lines demonstrated that NSC631570 is selectively toxic against cancer cells. (ukrin.com)
  • Live, apoptotic and inactive prices of HeLa cells treated with S-1. (euromed2016.com)
  • Supplies the IC50 worth of S-1 on HeLa and ITIC-4F PNT1-A cell lines (beliefs (euromed2016.com)
  • Amount 3 signifies the cytotoxicity of varied concentrations of S-1 in HeLa cells. (euromed2016.com)
  • Cytotoxic aftereffect of different dosages of S-1 on HeLa cell series. (euromed2016.com)
  • Apoptosis recognition by Annexin V affinity assay To be able to determine whether several concentrations (20, 50, 100?M) of S-1 impacts apoptosis of HeLa cell series. (euromed2016.com)
  • Apoptotic prices of HeLa cells after Annexin V staining. (euromed2016.com)
  • The amount of past due apoptotic cells was elevated in HeLa cells treated with different dosages of S-1 weighed against neglected (0?M) simply because a poor control. (euromed2016.com)
  • 4.?Debate Within this scholarly research, the cytotoxic aftereffect of low-dose cytotoxicity in HeLa cells that are CA-IX appearance, and the reduced cytotoxic aftereffect of low CA-IX appearance in PNT-1A cells may be the most important evidence that this product includes a selective impact. (euromed2016.com)
  • It had been backed by molecular methods such as for example Annexin V also, cell cycle, where in fact the substance exhibited anticancer activity on HeLa cells. (euromed2016.com)
  • An important implication of these findings is the number of viable cells remaining in harvested HeLa cells after culturing with different.Apoptosis detection by Annexin V affinity assay In order to determine whether numerous concentrations (20, 50, 100?M) of S-1 has an effect on apoptosis of HeLa cell collection. (euromed2016.com)
  • Physique 2 clearly shows that the sensitivity of the HeLa cell collection to S-1 is usually greater than that of PNT1-A cell collection. (euromed2016.com)
  • Lin A, Gallicchio VS. (2023) Stem Cell Therapy for Glioblastoma. (genesispub.org)
  • Because BRCA mutations are observed in fewer than 10% of cancer patients (cBioPortal: 6.7%) 11 , 12 , 13 the identification of additional genes that share synthetic lethal sensitivity relationships with mutated oncogenes or tumor suppressors would greatly enhance the implementation of tumor cell-specific synthetic lethal sensitivity to improve an anticancer therapeutic response. (nature.com)
  • Targeted therapy drugs are used to target specific genes and proteins of cancer cells to precisely identify and attack specific types of cancer cells. (medsci.org)
  • In vivo , CWO induced transcriptional changes in immune-related genes, resulting in cytotoxic T cell-dependent tumor regression. (biorxiv.org)
  • Further analysis with GenomeLab GeXP genetic system on brain tissues showed that the expression of most xenobiotic metabolism, cell progression, tumour suppressor, DNA damage and inflammation genes was maintained at normal level. (upm.edu.my)
  • STARD12 co-expressed genes participated in cell cycle and DNA replication, and STARD14 were enriched in ECM-receptor interaction. (medsci.org)
  • Recently we reported hub genes and miRNAs associated with the pathophysiology of cancer and cancer stemness/self-renewal property. (edu.in)
  • Gene expression experiments indicated that CARD9, BNIP3(L), TNFRSF-1B, and TNFRSF-25 genes are highly expressed in Ramos BL cells following treatment with CDBPA. (longdom.org)
  • In general, genes involved in stress response, cell cycle control, drug metabolism, apoptosis and growth were differentially expressed in response to Cr(VI) exposure. (cdc.gov)
  • Two novel compounds labelled as thioglycoside A and B were designed and evaluated on breast and colon cancer cell lines. (oncotarget.com)
  • Medicinal herbs contain multitarget compounds that can control cancer development and advancement. (bvsalud.org)
  • Compounds (C1-8 and doxorubicin) were placed to 96-well culture plate in triplicate order at doses of 1, 10, 100, 1000 μM and then K562 cells were seeded into the wells at the dose of 105/ml. (ijpsonline.com)
  • The metal complexes of the compounds had stronger cytotoxic effects and cleaved caspase-3 expression than their ligands. (ijpsonline.com)
  • Mitochondrial membrane potential was found at low levels in cells treated with Schiff base compounds and doxorubicin. (ijpsonline.com)
  • To study the molecular mechanism of natural compounds as Notch Signaling inhibitor in cancer cell lines: in silico and in vitro investigation (completed). (edu.in)
  • Conjugation of glucose with metabolic agents to selectively target cancer cells was inspired by the widespread use of radiolabeled glucose analog to visualize tumors and their metastases. (oncotarget.com)
  • It is suggested that curcumin can selectively kill tumor cells through its multifaceted metabolic effects, that culminate in its anti-oxidant and anti-inflammatory activities ( Hewlings and Kalman, 2017 ). (frontiersin.org)
  • The expanded NK cells were significantly more potent than unstimulated or IL-2-stimulated NK cells against acute myeloid leukemia cells in vitro . (aacrjournals.org)
  • Data exist that demonstrate isoflavones' potent antiproliferative effects on prostate cancer cells. (biomedcentral.com)
  • As far as LEV is concerned, in 2010 Bobustuc hypothesized that AED may modulate O-6 methylguanine-DNA methyltransferase (MGMT), a DNA repair protein that has an important role in tumor cell resistance to alkylating agents, and LEV was reported as the most potent MGMT inhibitor among several AED [ 10 ]. (biomedcentral.com)
  • Zhao S, Ye G, Fu G, Cheng JX, Yang BB, Peng C. Ganoderma lucidum exerts anti-tumor effects on ovarian cancer cells and enhances their sensitivity to cisplatin. (springer.com)
  • Collectively, our results indicate that JIB extract showed anti-tumor effects and synergized with cisplatin against B16/F10 cells, indicating the possibility of JIB extract to be developed as adjuvant therapy for melanoma. (medsci.org)
  • 12. Anticancer drugs exert adverse effects on the bone marrow resulting in decreased WBC's, platelets and RBC's termed myelosuppression. (studylib.net)
  • In December 2013, Hoffmann-La Roche, manufacturer of capecitabine (Xeloda), an oral agent for the treatment of breast and colorectal cancers, reported that in rare cases, patients using the drug may develop potentially fatal cutaneous disease, such as Stevens-Johnson syndrome or toxic epidermal necrolysis. (medscape.com)
  • Four herbal PD formula was then disassembled into 15 combinations of herbal ingredients and a cytotoxicity assay showed that the Pulsatillae chinensis exerted the predominant anti-PAC effect. (biomedcentral.com)
  • Methods: The present study evaluated the wound healing properties of Nigella sativa L. ( N. sativa) seed extracts using normal cell lines such as normal human dermal fibroblasts (NHDFs) and human umbilical vein endothelial cells (HUVECs). (bvsalud.org)
  • Bleb formation has been artificially induced in multiple lab cell models using different methods. (wikipedia.org)
  • however, they may lead to resistance in the later stages of cancer because of the cancer's innate resistance methods. (oncologynurseadvisor.com)
  • The development of clinically applicable methods to produce large numbers of fully functional NK cells is a critical step to maximize the potential of this approach. (aacrjournals.org)
  • Its therapeutic effects on urinary bladder cancer have already been assessed in two clinical studies of phase II cancers and showed clinical benefits [ 10 , 11 ]. (hindawi.com)
  • Besides expanding the biological knowledge of the effect exerted by the modifications in compound structures on cell phenotype, the molecular elements put in evidence in our study may provide promising targets for therapeutic interventions on TNBCs. (unipa.it)
  • Our results suggest that novel combinations such as BT and cisplatin might be an attractive therapeutic approach to enhance ovarian cancer chemosensitivity. (biomedcentral.com)
  • Our study provides insight regarding the crosstalk among tumor cells, CAFs, and immune cells mediated by lactate and offers therapeutic strategies for targeting LDHA enzymatic activity in PDAC cells. (jci.org)
  • Therapeutic approaches that target the metabolism of tumor cells have been a popular research topic in recent years. (spandidos-publications.com)
  • In this study, we investigated a plausible therapeutic synergism of a triple combination of CBD/CBG, curcumin, and piperine in the colon adenocarcinoma using HCT116 and HT29 cell lines. (frontiersin.org)
  • Because epigenetic alterations are associated with the pathogenesis and clinicopathological characteristics of cancer, they are thought to be useful biomarkers and therapeutic targets [ 1 ]. (biomedcentral.com)
  • Although the goal of Glioblastoma is not only to treat the disease but to cure it, current animal in vivo studies have shown promising therapeutic effects in mesenchymal stem cells, induced neural stem cells, and induced pluripotent stem cells. (genesispub.org)
  • While research has shown that each stem cell poses its own risk to the disease, their therapeutic effects have also shown encouraging and promising results. (genesispub.org)
  • This review outlines the research, progress, and potential therapeutic effects different stem cells have on Glioblastoma. (genesispub.org)
  • This study aimed to review the current progress researchers have made regarding stem cell therapeutic effects for Glioblastoma, how it is applied, and to discover the potential future progress and treatments these stem cells can create. (genesispub.org)
  • This process with possibly low cytotoxic results on regular cells may provide ITIC-4F a brand-new therapeutic advantage in the treating cervical cancer. (euromed2016.com)
  • For better management of the disease, we are trying to identify putative prognostic, diagnostic, and therapeutic biomarkers associated with cancer and cancer stemness at the gene and RNA (coding and non-coding) level. (edu.in)
  • Effect of Withania somnifera phytoconstituents on miRNA expression profile in breast cells: Therapeutic and Cytoprotective role. (edu.in)
  • Based on antineoplastic effect of brivaracetam and lacosamide on glioma cells, we assume that patients with glioma could benefit by the treatment with these two molecules, in addition to standard therapeutic options. (biomedcentral.com)
  • Cell viability was determined using Cell Counting Kit-8 assay. (biomedcentral.com)
  • To glean novel insights on how MDA-MB231 breast cancer cells respond to the cytotoxic effect induced by JAHA, and to compare the biological effect with the related compound SAHA, we have employed a combination of differential display-PCR, proteome analysis, and COMET assay techniques and shown some differences in the molecular signature profiles induced by exposure to either HDACis. (unipa.it)
  • The cytotoxic effects of drugs either alone or in combination were evaluated using presto-blue assay. (biomedcentral.com)
  • Khz cytotoxicity was measured using an MTT assay and the mitochondrial membrane potential (MMP)-related, calcium-induced generation of reactive oxygen species (ROS) in A549 cells was measured by flow cytometry. (springer.com)
  • Also, genotoxicity of AuNPL in HaCaT cells was investigated by the single cell alkaline comet assay. (ac.rs)
  • Apoptosis induction, cell cycle distribution, and migration abilities were assessed by cell death detection enzyme-linked immunoassay (ELISA), flow cytometry, and wound healing assay. (wjon.org)
  • To investigate the putative anti-proliferative effect, apoptosis assay, microRNA expression profile and study of cell cycle were performed. (biomedcentral.com)
  • Besides, 12% of patients have second- or third-degree skin reactions that are sensitive to light, and about 18% of patients develop cutaneous squamous-cell carcinoma and keratoacanthoma or occurred at the same time [ 6 ]. (medsci.org)
  • SUMMARY BLURB Essential oil derived from the camphor tree acts by stimulating immune cell-dependent regression of skin tumors in a mouse model of cutaneous squamous cell carcinoma. (biorxiv.org)
  • It is the outcome of many factors, including the cross-talk between tumor cells within the tumor microenvironment and the acquisition and accumulation of genetic and epigenetic alterations in tumor cells. (molcells.org)
  • HCC heterogeneity is believed to be the outcome of combinatorial effects, including the acquisition of genetic and epigenetic alterations in tumor cells, the cross-talk of cells within the tumor microenvironment, as well as the existence of a cancer stem cell (CSC) subpopulation that has the ability to self-renew and differentiate. (molcells.org)
  • Taken together, the present study revealed that MWCNTs exert epigenetic effects in the lungs of exposed animals, potentially driving the subsequent gene expression changes. (cdc.gov)
  • The efficacy of the BT-cisplatin combination depends upon the cell type and concentrations of cisplatin and BT. (biomedcentral.com)
  • In cisplatin-sensitive cell lines, BT and cisplatin were mostly antagonistic except when used at low concentrations, where synergy was observed. (biomedcentral.com)
  • In contrast, in cisplatin-resistant cells, BT-cisplatin combination treatment displayed synergistic effects at most of the drug ratios/concentrations. (biomedcentral.com)
  • Moreover, nontoxic concentrations of AuNPL did not cause considerable DNA damage of HaCaT cells, indicating low genotoxicity of the nanoparticles. (ac.rs)
  • It could exert cytotoxicity at pretty low concentrations (5000 nM). (achrinhibitor.com)
  • At lower NSC631570 concentrations malignant cells die as a result of apoptosis, at higher concentrations the formation of microtubules is prevented und polyploidy occurs (62). (ukrin.com)
  • Finally, lipid accumulation in cells induced to undergo adipogenesis and treated with BPC decreased although without significant differences at different concentrations. (unav.edu)
  • Max Planck Institute (MPI) cells, a non-transformed mouse line that has an AM phenotype and genotype, were treated with mass-, surface area- (s.a.), and particle number- (p.n.) equivalent concentrations of respirable asbestiform and non-asbestiform riebeckite/tremolite EMP for 24h. (cdc.gov)
  • The CAR-containing exosomes express a high level of cytotoxic molecules and inhibit tumour growth. (nature.com)
  • Genistein is known to inhibit both androgen-dependent and androgen-independent prostate cancer cell growth in vitro . (biomedcentral.com)
  • The cell cycle distribution was analyzed through PI staining and flow cytometry analysis, while apoptotic cells were measured by double staining with Annexin V-FITC and PI. (biomedcentral.com)
  • Flow cytometry analysis showed that the percentage of A549 cells in sub-G1 phase of the cell cycle increased in response to Khz treatment. (springer.com)
  • Cytoprotective properties of AuNPL towards HaCaT cells were examined by measuring the physiological and H2O2 induced intracellular reactive oxygen species (ROS) levels using flow cytometry. (ac.rs)
  • Apoptosis induction potential of each compound determined by mitochondrial membrane potential analysis (Rho123), cleaved caspase-3 expression analysis by flow cytometry and immunofluorescent staining and cell morphology analysis by giemza, hematoxylin and eosin and Papanicolaou protocols. (ijpsonline.com)
  • Expression of chemoresistance molecules was evaluated using flow cytometry in U87MG and human umbilical vein endothelial cells (HUVECs). (biomedcentral.com)
  • VALD-3 also regulated the Wnt/β-catenin signaling pathway in breast cancer cells, inhibiting the activation of downstream molecules. (researchsquare.com)
  • A 2D moving cell is able to use adhesive molecules to gain traction in its environment while blebs form at the leading edge. (wikipedia.org)
  • According to a hypothesis, polyphenol (PP) activity against several forms of cancer, proliferative diseases, inflammation and neurodegeneration is mainly exerted through the inhibiting and modulating activities against a wide range of receptors, enzymes and transcription molecules 88 . (bvsalud.org)
  • We assessed their cytotoxic effect after sensitizing cancer cells with insulin. (oncotarget.com)
  • Etoposide is a glycosidic derivative of podophyllotoxin that exerts a cytotoxic effect by stabilizing the normally transient covalent intermediates formed between the DNA substrate and topoisomerase II. (medscape.com)
  • IC50 concentration of AuNPL exerted cytoprotective effect against HaCaT cells by the significant reduction of the physiological intracellular ROS level. (ac.rs)
  • In the 1920s, Otto Heinrich Warburg discovered that cancer cells, unlike normal cells, use the glycolytic pathway to obtain energy for growth even in the presence of oxygen, which is a phenomenon known as 'aerobic glycolysis' or the Warburg effect ( 9 ), and aerobic glycolysis is a common metabolic phenotype in NSCLC ( 11 ). (spandidos-publications.com)
  • Compared with CAR-T cells, CAR exosomes do not express Programmed cell Death protein 1 (PD1), and their antitumour effect cannot be weakened by recombinant PD-L1 treatment. (nature.com)
  • From the in vivo study, results showed that treatment of 300 mg/kg of vanillin by intra-peritoneal injection caused the rats to be unconscious without exerting any negative effect on blood cells, kidney and liver. (upm.edu.my)
  • Compared with Cuc B treated group, a dramatic decrease of Cyclin B 1-bound Cdk1 was observed in ATM knockdown and Cuc B co-treatment (Fig. 4D).DiscussionMore focus has been paid for the anti-cancer effect of cucurbitacins in current years. (achrinhibitor.com)
  • The anti-proliferative effect of Cuc B on cancer cells has been reported everywhere. (achrinhibitor.com)
  • Researchers at the University of Natural Resources and Life Sciences, Vienna compared NSC631570's inhibitive effect on the reproduction of malignant and normal cells. (ukrin.com)
  • In a study of the effect of NSC631570 on K-562 erythroleucemia cells it was found that the preparation causes bimodal cell death. (ukrin.com)
  • S-1 exerts cytotoxic and anti-proliferative efficiency on CC cells but very own less effect on individual healthful PNT1-A cells (Amount 4). (euromed2016.com)
  • After inhibiting LDH, even in the presence of lactic acid, the function of effector T cells can be restored, which indicates that the effect of lactic acid on these immune cells is highly dependent on LDH. (medicaltrend.org)
  • The expression of pro-apoptotic proteins and anti-apoptotic proteins in MCF-7 and MDA-MB-231 cells was investigated by Western blotting. (researchsquare.com)
  • Iron and BIM (Bcl-2-interacting mediator of cell death) proteins were involved in the cytotoxic sensitization process. (jneurosci.org)
  • Cuproptosis is a newly discovered type of cell death in tumor, which is characterized by accumulation of intracellular copper leading to the aggregation of mitochondrial lipoproteins and destabilization of proteins. (biomedcentral.com)
  • 75,76 Tumor necrosis factor (TNF)-α inhibits apoptosis by activating NF-κB and its downstream pathway, including IL6 and IL8, in androgen-independent prostate cancer cells, whereas it promotes apoptosis in androgen-dependent cancer cells. (oncologynurseadvisor.com)
  • Thus, synergistic action of the integrants serves better combat force against breast cancer in the form of whole extract, hence aiming at a more lucrative paradigm while significantly regulating microRNAs associated with breast cancer migration and apoptosis. (bvsalud.org)
  • Along with lamellipodia, blebs serve an important role in cell migration. (wikipedia.org)
  • Moreover, P. paniceum could decrease the migration of HCT116 and HT29 cancer cells. (wjon.org)
  • P. paniceum also inhibits cell migration and exerts antimutagenicity, thereby suggesting that P. paniceum might be useful for colorectal cancer treatment. (wjon.org)
  • We propose that lcn2 is an autocrine mediator of reactive astrocytosis based on the multiple roles of lcn2 in the regulation of cell death, morphology, and migration of astrocytes. (jneurosci.org)
  • LCN2 protein induced upregulation of glial fibrillary acidic protein (GFAP), cell migration, and morphological changes similar to characteristic phenotypic changes termed reactive astrocytosis. (jneurosci.org)
  • Our results indicated that lcn2 is critical for cell death sensitization, stimulation of cell migration, and morphological changes of reactive astrocytes. (jneurosci.org)
  • The in vivo effects of β-peltatin and podophyllotoxin were evaluated on a subcutaneously-xenografted BxPC-3 cell nude mice model. (biomedcentral.com)
  • If confirmed in vivo , this conjugation may provide a means of new perspectives in muscle-invasive urinary bladder cancer treatment. (hindawi.com)
  • These findings establish a mechanism for co-targeting DNA damage-induced cell cycle checkpoints in combination with repair of cisplatin-DNA lesions in vivo using RNAi nanocarriers, and motivate further exploration of ASL as a generalized strategy to improve cancer treatment. (nature.com)
  • Aunque existe una evidencia de que el resveratrol es un potente agente chemopreventivo in vitro, la baja viabilidad del resveratrol en humanos puede ser un problema a la hora de considerarlo como tratamiento en vivo. (lacienciadelvino.com)
  • In zebrafishes, forced expression of rat lcn2 gene increased the number and thickness of cellular processes in GFAP-expressing radial glia cells, suggesting that lcn2 expression in glia cells plays an important role in vivo . (jneurosci.org)
  • Combination therapy for treatment of triple negative breast cancer: An in vitro and in vivo study. (edu.in)
  • CDBPA, possesses strong in vitro and in vivo activity against Ramos cells, representing a potential approach for therapy of Burkitt lymphoma. (longdom.org)
  • Although CNC exposures are associated with pulmonary inflammation and damage as well as oxidative stress responses and genotoxicity in vivo, studies evaluating cell transformation or tumorigenic potential of CNC's were not previously conducted. (cdc.gov)
  • Since BCL2, a protein that indirectly inhibits cell apoptosis, is required for certain chemotherapies to work, the absence of BCL2 obscures their uses in prostate cancer. (oncologynurseadvisor.com)
  • 70 Mcl1 (myeloid cell leukemia differentiation protein 1) and other members of the BCL family, such as BCL-xl (B-cell lymphoma-extra-large), are also involved in resistance to Interleukin (IL)-6, stromal cell derived factor-1, and cytokine-induced apoptosis. (oncologynurseadvisor.com)
  • STAT3, one of the seven members on the STAT transcription issue protein loved ones, has been implicated as a potential target for cancer therapy. (achrinhibitor.com)
  • Forced expression of lcn2 or treatment with LCN2 protein increased the sensitivity of astrocytes to cytotoxic stimuli. (jneurosci.org)
  • This investigation aims to analyse the in vitro effects of cisplatin and sunitinib malate in isolation and in combination, on one human nonmuscle invasive urinary bladder-cancer cell line (5637) and on two human muscle-invasive urinary bladder-cancer cell lines (T24 and HT1376). (hindawi.com)
  • The effects of VALD-3 on the cell cycle were analyzed in MCF-7 and MDA-MB-231 cells by PI single staining. (researchsquare.com)
  • Regarding the adverse effects and consequences of current treatments, cancers' health, and socio-economical aspects have become more complicated, leaving research aimed at improved or new treatments on top priority. (bvsalud.org)
  • This study aimed to investigate the anti-proliferative effects of Khz on A549 lung cancer cells. (springer.com)
  • After 14 weeks of vanillin administration, the effects of vanillin on blood cells, kidney, liver and brain were studied. (upm.edu.my)
  • This shows that 5% ethanol could pose negative effects onto the brain cells. (upm.edu.my)
  • Triple treatment showed synergism in terms of exhibiting anti-tumorigenic effects by activating the Hippo YAP signaling pathway in the HCT116 cell line. (frontiersin.org)
  • In addition to their anticonvulsant action, some drugs have been documented for cytotoxic effects. (biomedcentral.com)
  • Aim of this study was to evaluate possible in vitro cytotoxic effects of two new-generation antiepileptic drugs on a human glioma cell line U87MG. (biomedcentral.com)
  • Brivaracetam and lacosamide showed a dose-dependent cytotoxic and anti-migratory effects. (biomedcentral.com)
  • Black seed might have effects in the body that help boost the immune system, fight cancer, prevent pregnancy, reduce swelling, and lessen allergic reactions by acting as an antihistamine. (medlineplus.gov)
  • JAHA's cytotoxic activity on MDA-MB231 triple negative breast cancer (TNBC) cells at 72 h has been previously demonstrated with an IC50 of 8.45 μM. (unipa.it)
  • Findings from the in vitro study showed that vanillin was cytotoxic towards HT-29 and 3T3 cells with the IC50 value of 400 μg/ml and 1000 μg/ml respectively. (upm.edu.my)
  • Here, we report that cancer-associated fibroblasts (CAFs) with restricted glucose availability utilize lactate from glycolysis-enhanced cancer cells as a fuel and exert immunosuppressive activity in the PDAC TME. (jci.org)
  • Moreover, lactate-stimulated CAFs upregulated IL-6 expression and suppressed cytotoxic immune cell activity synergistically with lactate. (jci.org)
  • We tested an essential-oil derivative, camphor white oil (CWO), for anti-tumor activity in a mouse model of keratinocyte-derived skin cancer. (biorxiv.org)
  • Dietary intervention with isoflavone supplementation may have biologic activity in men with biochemical recurrent prostate cancer as shown by a decline in the slope of PSA. (biomedcentral.com)
  • This study may lend support to the literature that nutritional supplements have biologic activity in prostate cancer and therefore, further studies with these agents in randomized clinical trials should be encouraged. (biomedcentral.com)
  • AR activity has been implicated as pivotal in several phases of prostate cancer: origin, transition to androgen independent status, and progression. (biomedcentral.com)
  • Astrocytes, the most abundant glial cell type in the brain, provide metabolic and trophic support to neurons and modulate synaptic activity. (jneurosci.org)
  • Increasing evidences supporting the potential use of SIRT inhibitors (SIRTi) for the treatment of cancer, HIV infection, and muscular diseases and of SIRT activators (SIRTa) for age-related disorders have led to the identification of many SIRT modulators over recent years, mainly through chemical library screening and catalytic mechanism-based design approaches, often combined with structure-activity relationship (SAR) investigations. (biomedcentral.com)
  • in the same model, natural killer (NK) cells in tumor tissue depleted by LDHA show higher killing activity, indicating LDH activity The increase in tumor immune escape by suppressing the function of immune cells. (medicaltrend.org)
  • Polyphenols exert preventive activity against infectious and degenerative diseases including oral diseases. (bvsalud.org)
  • Together, these studies identify T cell-mediated tumor regression as the mechanism through which a plant-derived essential oil diminishes established tumor burden. (biorxiv.org)
  • A third potential mechanism deals with the limited amount of blood supply and hence, limited cytotoxic drug accessibility to the source of cancer. (oncologynurseadvisor.com)
  • A fourth mechanism suggests that cytotoxic drugs are removed from the source using efflux pumps, and the last mechanism is microtubule alterations that affect cytotoxic drug attachment to cancer cells. (oncologynurseadvisor.com)
  • Daily topical treatment with CWO induced dramatic regression of pre-malignant skin tumors and a two-fold reduction in cutaneous squamous cell carcinomas. (biorxiv.org)
  • This means that NSC631570 can differentiate between healthy and malignant cells, a feature not yet managed by other anti-cancer drugs. (ukrin.com)
  • Laser scanning microscopy showed a high capacity to absorb NSC631570 in malignant cells while absorption in normal cells was considerable lower under the same experimental conditions (36). (ukrin.com)
  • Lung cancer is the first leading diagnosed malignant tumor globally [ 1 ]. (medsci.org)
  • Hepatocellular carcinoma (HCC), a highly malignant disease and the third leading cause of all cancer mortalities worldwide, often responses poorly to current treatments and results in dismal outcomes due to frequent chemoresistance and tumor relapse. (molcells.org)
  • Human exposures to asbestiform elongate mineral particles (EMP) may lead to diffuse fibrosis, lung cancer, malignant mesothelioma and autoimmune diseases. (cdc.gov)
  • Tumor microenvironment (TME) accelerates the metabolism of tumor cells and cancer-related fibroblasts to form an immune environment that promotes tumor growth. (medicaltrend.org)
  • In IMIDs, lactic acid is produced by mesenchymal fibroblasts and metabolically active infiltrating immune cells, and is a key driver of the microenvironment of inflammatory tissues. (medicaltrend.org)
  • Khz, a naturally occurring compound derived from the fusion of Ganoderma lucidum and Polyporus umbellatus mycelia, inhibits the growth of cancer cells. (springer.com)
  • In vitro tests showed that after incubation with NSC631570 normal liver cells and Ehrilch tumour ascitic cells demonstrate different oxygen consumption: after initial increase, oxygen consumption in cancer cells falls to zero whereas oxygen consumption in normal cells returns to normal and the cells remain undamaged (38). (ukrin.com)
  • This study brought the first indications that, in contrast to its starting substances thiotepa (a well known cytostatic agent) and greater celandine alkaloids, NSC631570 is in fact only toxic against cancer cells and not against normal cells. (ukrin.com)
  • Doxorubicin, a cytotoxic anthracycline antibiotic isolated from cultures of Streptomyces peucetius var. (medscape.com)
  • Combination drug therapy appears a promising approach to overcome drug resistance and reduce drug-related toxicities in ovarian cancer treatments. (biomedcentral.com)
  • Low doses of BT and cisplatin enhanced efficiency of cisplatin treatment in all the ovarian cancer cell lines tested. (biomedcentral.com)
  • Drug resistance to currently used chemotherapies is the fundamental cause of recurrence and poor overall survival in ovarian cancer patients [ 1 - 3 ]. (biomedcentral.com)
  • In current clinical development, targeting CD19 + B cell malignancies, which include acute and chronic B-cell leukaemia and B-cell non-Hodgkin lymphomas (NHLs), with anti-CD19 CAR-T cells is one of the most advanced adoptive T-cell therapies and has been approved by the FDA. (nature.com)
  • We therefore adapted the K562-mb15-41BBL stimulation method to large-scale clinical-grade conditions, generating large numbers of highly cytotoxic NK cells. (aacrjournals.org)
  • The results that we report here provide rationale and practical platform for clinical testing of expanded and activated NK cells for cell therapy of cancer. (aacrjournals.org)
  • The most provocative data supporting the influence of dietary factors on the clinical incidence of prostate cancer come from international studies and from studies of disease expression in immigrant populations. (biomedcentral.com)
  • These cultural differences may contribute to the lower rates of clinical prostate cancer in the Far East compared to Northern Europe and North America. (biomedcentral.com)
  • In addition, recent evidence suggests that soy consumption contributes to the lower clinical incidence of prostate cancer in Asian countries [ 5 ]. (biomedcentral.com)
  • Cells in the microenvironment of TME and IMID have completely different responses to lactic acid, so new research in this context has a variety of clinical application potentials. (medicaltrend.org)
  • Similar to other cancers, HCC is heterogeneous in terms of cellular morphology, molecular profiles and clinical outcome. (molcells.org)
  • The standard approach for muscle-invasive urinary bladder cancer treatment is based on a radical cystectomy with bilateral pelvic lymph node dissection. (hindawi.com)
  • Despite considerable advancements in cancer treatment, the survival rate of PAC remains largely consistent for the past 60 years. (biomedcentral.com)
  • The traditional Chinese medicine formula Pulsatilla Decoction (PD) has been clinically used to treat inflammatory diseases for millennia and recently as a supplementary anti-cancer treatment in China. (biomedcentral.com)
  • The concept of synthetic lethality (SL) holds great promise for the treatment of human cancers, best exemplified by the now widespread use of PARP inhibitors in BRCA mutant cancers. (nature.com)
  • Treatment with P. paniceum caused a loss of cell viability in HCT116 and HT29 cells (not found in HEK293), which had an IC 50 (half-maximal inhibitory concentration) of 1,156.2 and 1,207.0 µg/mL, respectively. (wjon.org)
  • We also found that P. paniceum treatment increased apoptosis and arrested of the cell cycle at G0/G1 remarkably when compared with the control group. (wjon.org)
  • Genetically engineered T cells expressing a chimeric antigen receptor (CAR) are rapidly emerging a promising new treatment for haematological and non-haematological malignancies. (nature.com)
  • Although a strong response was observed for CAR-T cells in patients with treatment-refractory haematologic malignancies, only modest outcomes have been reported in solid tumours. (nature.com)
  • Treatment is aimed at reducing the risk of future recurrence, thereby reducing breast cancer−related morbidity and mortality. (medscape.com)
  • In patients receiving adjuvant aromatase inhibitor therapy for breast cancer who are at high risk for fracture, the monoclonal antibody denosumab or either of the bisphosphonates zoledronic acid and pamidronate may be added to the treatment regimen to increase bone mass. (medscape.com)
  • In terms of tumor treatment, Astragalus polysaccharides (PG2) have been shown to enhance the M1 polarization of macrophages, functional maturation of dendritic cells, and T cell-mediated anticancer immune responses in patients with lung cancer. (baituxiao.com)
  • The seven members of this family of enzymes are considered potential targets for the treatment of human pathologies including neurodegenerative diseases, cardiovascular diseases, and cancer. (biomedcentral.com)
  • Therefore, lactic acid treatment reduces effector T cell function without affecting Treg cell function. (medicaltrend.org)
  • The Cr-induced overexpression of the HO-1 gene in the BSO-treated cells was significantly higher than in those cells without BSO treatment. (cdc.gov)
  • lt;p>The statistical data of the recent decades demonstrate a rapid growth of breast cancer (BCa) incidence and a tendency toward its increase especially in young women. (exp-oncology.com.ua)
  • the iron-doxorubicin complex induces the production of free radicals that can destroy DNA and cancer cells. (medscape.com)
  • The aim of this paper is to analyse sunitinib malate in vitro ability to enhance cisplatin cytotoxicity in T24, 5637, and HT1376 human urinary bladder-cancer cell lines. (hindawi.com)
  • Urinary bladder cancer is a common malignancy of the urinary tract, being four times higher in men than in women [ 1 ]. (hindawi.com)
  • Nonetheless, there is a scarce of data available about the combination of sunitinib malate and cisplatin on urinary bladder cancer. (hindawi.com)
  • The study was performed on the 5637, T24, and HT1376 urinary bladder-cancer cell lines. (hindawi.com)
  • Miyajima, A, Nakashima J, Yoshioka K. Role of reactive oxygen species in cis-dichlorodiammineplatium-induced cytotoxicity on bladder cancer cells. (springer.com)
  • Metastatic castration-resistant prostate cancer (mCRPC) is a type of cancer that is resistant to conventional prostate cancer treatments, such as androgen deprivation therapies (ADTs) and other chemotherapies. (oncologynurseadvisor.com)
  • Our findings revealed that different genetic backgrounds of HCT116 and HT29 cell lines resulted in divergent responses to the combination treatments. (frontiersin.org)
  • DNA damage assessment and cell cycle analysis revealed differences in the modes of cell death between asbestos and respective CF. There was an increase in chemokines, but not pro-inflammatory cytokines after all EMP treatments. (cdc.gov)
  • Liver hepatocellular carcinoma (LIHC) ranks sixth among the most common types of cancer with a high mortality rate. (biomedcentral.com)
  • Liver hepatocellular carcinoma (LIHC) is one of the most common malignancies worldwide, ranking as the sixth most common type of cancer globally [ 1 ]. (biomedcentral.com)
  • According to the World Health Organization, liver cancer will kill more than 1 million people by 2030 [ 2 ]. (biomedcentral.com)
  • However, the mitochondrial oxidative phosphorylation (OXPHOS) pathway in tumor cells has also been implicated in lung cancer metabolism. (spandidos-publications.com)
  • Lung cancer is the most common cause of cancer-related death worldwide ( 1 ). (spandidos-publications.com)
  • According to the latest statistical report from the American Cancer Center from 2021, lung cancer has the second-highest incidence and the highest mortality rate among all malignancies ( 2 ). (spandidos-publications.com)
  • There are primarily two types of lung cancer: Non-small cell lung cancer (NSCLC) and SCLC, and the former accounts for ~85% of all lung cancer cases ( 3 ). (spandidos-publications.com)
  • It has been reported that lung cancer cells exhibit upregulated expression of all key glycolytic enzymes [hexokinase 2 (HK2), phosphofructokinase and pyruvate kinase (PK)] ( 13 ), suggesting that the essential enzymes of the aerobic glycolytic pathway have a critical role in the development of lung carcinoma. (spandidos-publications.com)
  • Astragalus polysaccharides (PG2) Enhances the M1 Polarization of Macrophages, Functional Maturation of Dendritic Cells, and T Cell-Mediated Anticancer Immune Responses in Patients with Lung Cancer. (baituxiao.com)
  • Non-small cell lung cancer (NSCLC) accounts for 85-90% of cases, while lung adenocarcinoma (LUAD) is the most common subtype [ 2 ]. (medsci.org)
  • To investigate P. paniceum 's anticancer ability, HCT116 and HT29 cell lines were treated with a water extract containing P. paniceum , and then the cell viability was examined using the trypan blue exclusion method which were compared to HEK293 (non-cancerous cells). (wjon.org)
  • We found that P. paniceum significantly inhibited the proliferative function of HCT116 and HT29 cells. (wjon.org)
  • We evaluated the efficacy of isoflavone in patients with PSA recurrent prostate cancer after prior therapy. (biomedcentral.com)