Cancer cells small rna molecules micro rna that regulates. Medical search. Frequent questions

MicroRNAs function to regulate the expression levels of other genes by several mechanisms, whilst siRNAs are involved primarily with the RNA interference (RNAi) pathway. (wikipedia.org)
Specifically, he is determining how certain genes drive cancer growth and looking for ways to disable those genes. (ascopost.com)
The objective of our research is to figure out how we can use drugs to 'turn off' cancer-promoting genes as a way to eliminate tumors," he said. (ascopost.com)
In his lab, Dr. Vakoc performs genetic screening with the gene-editing technique CRISPR to figure out which genes and proteins are most important for cancer. (ascopost.com)
About 30% of the human protein-coding genes are negatively regulated by miRNAs which suggests that they have a major role in regulating gene expression. (usda.gov)
In animals with cancer, the results showed that too much miR-21, or overexpression, promotes the formation, growth and survival of new tumours by turning off certain genes that normally allow cancer cells to die. (myvmc.com)
Up to 30% of human protein-coding genes may be regulated by miRNAs ( 8 , 9 ). (spandidos-publications.com)
The multifunctional regulator nuclear factor erythroid 2-related factor (Nrf2) is considered not only as a cytoprotective factor regulating the expression of genes coding for anti-oxidant, anti-inflammatory and detoxifying proteins, but it is also a powerful modulator of species longevity. (springer.com)
The discovery of the antioxidant response element (ARE) have led to the conclusion that the battery of genes, including glutamate-cysteine ligase (GCL), thioredoxin reductase 1 (Txnrd1), NAD(P)H-quinone oxidoreductase 1 (NQO1) and heme oxygenase-1 (HMOX1) is regulated through Nrf2 binding to this consensus binding sequence [ 3 ]. (springer.com)
The changes in the G1-to-S cell cycle pathway showed that 1,25(OH) 2 D 3 down-regulates the genes influencing the G1-to-S phase transition. (biomedcentral.com)
Six of the nine differentially expressed microRNAs target genes in the extended network, including CLSPN , an important checkpoint regulator in the cell cycle that was down-regulated, and FZD5 , a receptor for Wnt proteins that was up-regulated. (biomedcentral.com)
Genetic susceptibility to breast cancer is highly increased with mutations in breast cancer susceptibility genes (BRCA1 and BRCA2). (biogenex.com)
MicroRNA (miRNA) belongs to the family of single-stranded noncoding RNA with approximately 22 nucleotides that negatively regulates the target genes at the posttranscriptional level, which is involved in a wide range of biological processes [ 11 ]. (hindawi.com)
Each miRNA can have multiple target genes, and several miRNAs can regulate the same gene. (researchsquare.com)
MicroRNAs have been reported to regulate about one-third of human genes [ 11 ] . (researchsquare.com)
The U-M researchers want to study whether miRNAs are regulating the cell's nucleus, which would have an effect on the number of genes expressed through epigenetics. (umich.edu)
Some miRNAs are hosted in pri-miRNAs annotated as long non-coding RNAs (lncRNAs) and defined as MIRHGs (for miRNA Host Genes). (mdpi.com)
Background: As microRNAs play important roles in cancer development and progression by regulating the expressions of oncogenes and tumor suppressor genes though interacting with the 3' untranslated region (UTR) of target genes, we aimed to evaluate the association between genetic variants of miRNAs and their binding sites and prognosis in patients with colorectal cancer (CRC). (iiarjournals.org)
For CRC, polymorphisms in the genes involved in tumor progression, apoptosis, and angiogenesis have already been extensively studied for their association with cancer susceptibility and prognosis ( 1 - 7 ). (iiarjournals.org)
In general, microRNAs, a class of small (~21 nucleotide) non-coding RNAs, negatively regulate the expression of their target genes. (spandidos-publications.com)
The progression of hepatocellular carcinogenesis is thought to involve the deregulation of genes that are critical to cellular processes, such as cell cycle control, cell growth, apoptosis, cell migration and spreading. (spandidos-publications.com)
MiR-326 plays an anticancer role in a variety of malignant tumors and targets different genes in glioma, endometrial cancer, and cervical cancer [ 11 - 14 ]. (hindawi.com)
MicroRNAs (miRNAs), a recently identified class of endogenous, small (~22 nt), non-protein coding, single-stranded RNA molecules, negatively regulate protein-coding genes by base-pair matching with the 3' UTRs of mRNAs. (biomedcentral.com)
MicroRNAs (miRNAs) are a class of small noncoding RNA molecules that negatively regulate the expression of target genes by either mRNA degradation or translational inhibition. (biomedcentral.com)
The full sequencing of the human genome revealed the surprising existence of a vast assortment of small RNA molecules that have the ability to regulate the activity of genes. (pewtrusts.org)
Cancer genomics analysis revealed that 36 of the most differentially expressed mRNAs were involved in a pancreatic cancer network and were associated with many critical mutated genes such as TP53, KRAS, SMAD4, and CDKN2A. (jcancer.org)
The enzyme phosphatase and tensin homologue (PTEN) gene is one of the most frequently inactivated tumor suppressor genes in a variety of cancers. (biosemiotics2013.org)
The molecule miR-450a is usually underexpressed in tumors, but experiments in cultured cells and mice showed that when overexpressed, it can have positive effects on the treatment of cancer by silencing genes involved in cell migration and tumor energy metabolism. (fapesp.br)
They bind to messenger RNAs expressed by genes and break them down or prevent them from being translated into proteins. (fapesp.br)
However, it was still necessary to identify the proliferation and cell invasion genes that were inhibited by the molecule. (fapesp.br)
After the characterization stage, we had to find out which cellular migration and invasion genes were regulated by miR-450a," Silva Junior said. (fapesp.br)
The researchers found that miR-450a blocked genes associated with vimentin, a protein in the cell invasion pathway. (fapesp.br)
It also dysregulated genes involved in the epithelial-to-mesenchymal transition pathway - essential for cell migration, invasion and resistance to apoptosis (programmed cell death) - thereby inhibiting the process of metastasis. (fapesp.br)
The molecule also decreased tumor growth by inhibiting one mitochondrial gene ( MT-ND2 ) and three nuclear genes ( ACO2 , ATP5B and TIMMDC1 ) involved in one of the stages of cell respiration and in energy production (oxidative phosphorylation). (fapesp.br)
Function annotation of target genes indicated that most of them tend to target genes involved in signal transduction and cell communication, especially cancer-related PI3K-Akt and p53 signaling pathway. (ijcto.org)
For example, single cell analysis allows for the direct measurement of gene expression kinetics, or for the unambiguous identification of co-regulated genes, even in the presence of de-synchronization and heterogeneity that could obscure population-averaged measurements. (justia.com)
Scientists from the Max Planck Institute for Heart and Lung Research in Bad Nauheim have now discovered that the two micro RNA molecules miR-1 and miR-133 in the adult heart inactivate two genes that normally force cell division. (mpg.de)
Micro-RNAs are short, non-coding RNA molecules that are crucially involved in regulating the activity of genes. (mpg.de)
Indeed, the expression of the genes for the oncostatin M receptor and the FGF receptor 1 increased in these cells, and with it the number of receptor molecules. (mpg.de)
That only a very small part of the DNA chain consisted of genes which code for protein could not be explained and those parts were irreverently called junk DNA as their function was not understood. (lu.se)
This article briefly discusses tumor suppressor genes and then focuses on the role of proto-oncogenes in childhood cancer. (medscape.com)
Inactivation of tumor suppressor genes, whose products normally provide negative control of cell proliferation, contributes to malignant transformation in various cell types. (medscape.com)
Like Rb protein, many of the proteins encoded by tumor suppressor genes act at specific points in the cell cycle. (medscape.com)
TP53 activates the expression of genes involved in apoptosis, cell cycle regulation (p21), and MDM2. (medscape.com)
Another important class of tumor suppressor genes involved in cell cycle control and in the generation of human cancers is the cyclin-dependent kinase (CDK) inhibitors. (medscape.com)

DNA has an important job-it tells your cells which proteins to make. (udel.edu)
In cells, the arrangement of these four nucleotides determines the output-the proteins made by the DNA. (udel.edu)
Previous work has shown how powerful DNA nanotechnology might possibly be, and we know how powerful proteins are within cells," said Rebecca P. Chen. (udel.edu)
Most traditional targeted therapies block the activity of cancer-causing proteins. (ascopost.com)
His lab studies noncoding RNAs, which lack the instructions for making proteins. (ascopost.com)
MicroRNAs regulate messenger RNA molecules, which do encode proteins," Dr. Mendell said. (ascopost.com)
We want to understand why our genome is producing so many RNAs that do not encode proteins and what role they may have in diseases, including cancer," he said. (ascopost.com)
These small snippets of RNA - the chemical cousin of DNA - normally help coordinate and regulate the production of specific proteins in cells. (myvmc.com)
The effect of miR-126 expression on target proteins was assessed using miR-126 mimics or miR-126 inhibitors in ESCC cell lines. (spandidos-publications.com)
Wnt inhibitors arbitrated modifications affecting Wnt pathway proteins on the cell membranes, in the cytoplasm, and in the nucleus have been shown to span essential contributions in the initiation, progression, and chemoresistance of ovarian cancer. (edu.au)
In a person's cells, RNA receives instructions from DNA about how to build proteins, then directs the cell to build those proteins. (umich.edu)
However, scientists estimate that while upward of 95 percent of DNA transcribes into RNA, most of that RNA does not actually translate into proteins. (umich.edu)
Some of these RNA strands break into smaller chunks called microRNAs, or miRNAs, which stop messenger RNA from producing proteins. (umich.edu)
Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. (thermofisher.com)
The DNA instructions are transcribed into RNA molecules called messenger RNAs (mRNAs), which serve to produce these proteins (translation). (debra.org.uk)
However, some RNAs, called non-coding RNAs, are not translated into proteins but regulate the amount of proteins produced. (debra.org.uk)
We will also identify proteins that specifically interact with and alter the structure of the large primary microRNA, differentially altering access to the enzymes that process and release its individual microRNAs. (pewtrusts.org)
To identify factors that help non-cancerous mammary gland stem cells (MaSCs) resist differentiation and retain their capacity to self-renew, Yibin Kang, the Warner-Lambert/Parke-Davis Professor of Molecular Biology, and colleagues searched for short RNA molecules called microRNAs that can bind and inhibit protein-coding messenger RNAs to reduce the levels of specific proteins. (medicalxpress.com)
For example, exosomes and nanovesicles secreted by living cells serve as intercellular couriers of mRNA, microRNAs (miRNAs), long noncoding RNAs (lncRNAs), and proteins and have thus garnered considerable interest [ 3 ]. (jcancer.org)
Constitutive activation of STAT proteins notably of STAT3 is definitely detected in many human being tumor cells and cells transformed by oncoproteins [19]-[21]. (biosemiotics2013.org)
MicroRNAs like miR-450a are small RNAs that do not encode proteins but perform a regulatory role in the genome and hence in several intracellular processes. (fapesp.br)
In 1958, Francis Crick coined the concept of the central dogma of molecular biology, which can be succinctly described as DNA coding for RNA and RNA coding for proteins. (lu.se)

Background: MicroRNAs (miRNA) are small, highly conserved, non-coding RNAs that regulate gene expression of target mRNAs through cleavage or translational inhibition. (usda.gov)
Next generation miRNA sequencing identified a panel of five miRNAs associated with prostate cancer recurrence and metastasis. (oncotarget.com)
We hypothesize that cellular networks of miRNA-mRNA interactions are involved in carboplatin resistance in lung and ovarian cancer. (southcoastbiosciencesdtp.ac.uk)
Initially, to evaluate which miRNA-mRNA interaction confers resistance to carboplatin in lung and ovarian cancers, we will integrate miRNA and RNA sequencing in non-resistant and resistant cancer cell lines. (southcoastbiosciencesdtp.ac.uk)
Furthermore, to understand their mechanism of action we will establish the first miRNA-based single-cell CRISPR screen to evaluate how selected carboplatin-resistance miRNA-mRNA networks act in carboplatin resistance at single-cell resolution. (southcoastbiosciencesdtp.ac.uk)
The Discovery of miRNA-target networks involved in this process will provide new insights into the underlying evolutionary processes and, hence, into the principles of evolution as well as new therapeutic avenues to overcome lung and ovarian cancer relapse. (southcoastbiosciencesdtp.ac.uk)
Dysregulation of miRNA has been widely reported in many cancer types, including breast cancer. (biogenex.com)
Although numerous methods are available for gaining information about miRNA signatures, in situ hybridization (ISH) assay is a powerful tool that allows direct assessment of malignant cells. (biogenex.com)
BioGenex miRNA probes are dual-end labeled on 3' and 5' with five FAM molecules that amplify the signal, giving intense stains. (biogenex.com)
BioGenex is pleased to launch two Super Sensitive TM Nucleic Acid miRNA in situ hybridization (SSNA miRNA ISH) probes and automated systems for differentiation of wild type and BRCA mutated breast cancer. (biogenex.com)
As compared with wild type breast cancer, expression of miR-17 and miR-21 was downregulated in BRCA mutated breast cancer, suggesting that the miRNA expression pattern may serve as a potential biomarker in predicting BRCA mutation status in invasive breast cancer. (biogenex.com)
A single mRNA is regulated by multiple miRNAs, and individual miRNA targets even hundreds of mRNAs, leading to complicated regulatory networks [ 12 ]. (hindawi.com)
Regulation of single nucleotide polymorphisms (SNP) in micro-RNA (miRNA) on the host cells may be one of the most important factors influencing the occurrence of cervical cancer based on the prevalence of HPV infection and the development of cervical cancer. (researchsquare.com)
In order to explore the contribution of miRNA polymorphism to the occurrence and development of cervical cancer, we conducted an analytical study. (researchsquare.com)
The miRNA-146a rs2910164 mutation significantly reduced the risk of cervical cancer in both recessive model (OR= 0.804, 95%CI= 0.652-0.992, P = 0.042；CC vs. CG+GG) and allelic model (OR= 0.845, 95%CI= 0.721-0.991, P = 0.038；C vs. G). There was no significant correlation between miRNA -499 rs3746444 and the risk of cervical cancer. (researchsquare.com)
In summary, this meta-analysis shows that the mutant genotypes of miRNA -146a rs2910164 and miRNA -196a2 rs11614913 are associated with a reduced risk of cervical cancer. (researchsquare.com)
Live cells showing the trajectories of single miRNA molecules. (umich.edu)
To track the miRNA molecules, the researchers attach what's called a fluorophore to the molecule. (umich.edu)
Using a powerful microscope, the researchers can pick up the light, tracking the miRNA at a single-molecule level. (umich.edu)
First, they observe what the miRNAs are doing in the living cell at different points in time after they've been injected a miRNA with the fluorophore attached. (umich.edu)
Previously, scientists thought miRNA only regulated RNA in the cytoplasm of the cell, but more evidence shows miRNA is present in the cell's nucleus where the DNA is housed. (umich.edu)
Researchers have identified miRNA signatures associated with different lung cancer subtypes and stages. (newspatrolling.com)
miRNAs are highly conserved, small, non-coding RNAs that negatively regulate gene expression in vertebrates through multiple mechanisms, such as complimentary base pairing with the 3′-UTR of their target mRNAs, resulting in translational repression, mRNA cleavage and mRNA decay initiated by miRNA-guided rapid deadenylation ( 10 ). (spandidos-publications.com)
Like lncRNA, miRNA has been widely recognized in cancer. (hindawi.com)
The miRNA/mRNA high-throughput sequencing suggested that downregulation of circ-EPB41 promoted microRNA (miR)-486-3p and suppressed eukaryotic translation initiation factor 5A (eIF5A) expression. (biomedcentral.com)
For instance, circFGFR1 may interact directly with miR-381-3p and function as a miRNA sponge to upregulate expression of miR-381-3p target gene C-X-C motif chemokine receptor 4, which enhances NSCLC progression as well as resistance to anti-programmed cell death 1-based therapy [ 11 ]. (biomedcentral.com)
Moreover, exosomal miRNA-130a was transferred from CAFs to recipient NSCLC cells and knockdown of miRNA-130a reversed the effect of CAFs-derived exosomes during chemoresistance of NSCLC cells. (dovepress.com)
Furthermore, pumilio homolog 2 (PUM2), a RNA-binding protein, mediated the packaging of miRNA-130a into exosomes. (dovepress.com)
Taken together, these results suggest that CAFs-derived exosomes confer cisplatin resistance of NSCLC cells through transferring miRNA-130a and that PUM2 is a critical factor for packaging miRNA-130a into exosomes. (dovepress.com)

Micro RNAs (MiRNAs) are endogenous, small RNA molecules that were identified in a wide range of eukaryotes. (usda.gov)
MicroRNAs (miRNAs), a class of small, endogenous, non-coding RNAs, are able to regulate gene expression by translational repression or mRNA degradation of the target, thereby affecting critical functions in various physiological processes, ranging from cell proliferation to apoptosis ( 8 , 9 ). (iiarjournals.org)
RNA silencing at the transcriptional and posttranscriptional levels regulates endogenous gene expression, controls invading transposable elements (TEs), and protects the cell against viruses. (scentoferos.com)
SNHG3 was identified as a competitive endogenous RNA molecule to promote the malignant progression of colorectal cancer [ 8 ]. (hindawi.com)

Mature microRNAs (miRNAs) are a class of small, well-conserved, non-coding RNA molecules that silence gene expression usually by interfering with mRNA stability or protein translation ( 6 , 7 ). (spandidos-publications.com)
MicroRNAs (miRNAs) are small RNA molecules that repress post-transcriptional gene expression by interacting with the 3'UTR of mRNA targets. (southcoastbiosciencesdtp.ac.uk)
In this study, we performed an integrative network-based analysis using a publicly available data set studying the role of 1,25-dihydroxyvitamin D 3 (1,25(OH) 2 D 3 ) in prostate cancer cells on mRNA and microRNA level. (biomedcentral.com)
The extendable network-based tools PathVisio and Cytoscape enable straightforward, in-depth and integrative analysis of mRNA and microRNA expression data in 1,25(OH) 2 D 3 -treated cancer cells. (biomedcentral.com)
Nowadays high-throughput technologies enable the measurements of mRNA and microRNA expression on a large scale. (biomedcentral.com)
In the present study, we will combine pathway- and network-based methods to decipher the regulatory action of 1,25(OH) 2 D 3 in prostate cancer cells on mRNA and microRNA level. (biomedcentral.com)
Ranjan J. Perera, Ph.D., associate professor of oncology at the Johns Hopkins University School of Medicine, and colleagues report that using a specialized transcript sequencing method called BRIC-seq, they have identified highly stable and unstable mRNA gene transcripts that participate in cell growth and invasion during melanoma progression. (news-medical.net)
miRNAs exert their function via base pairing with complementary mRNA molecules, resulting in gene silencing via transcriptional repression or target degradation. (biogenex.com)
Chen J, Wang S, Jia S, Ding G, Jiang G, Cao L. Integrated Analysis of Long Non-Coding RNA and mRNA Expression Profile in Pancreatic Cancer Derived Exosomes Treated Dendritic Cells by Microarray Analysis. (jcancer.org)

In addition, the impact of miR-126 on cell proliferation, apoptosis, migration and invasion was detected in ESCC cell lines. (spandidos-publications.com)
miR-126 mimics downregulated the expression of IRS-1 and GOLPH3 protein and suppressed the proliferation, migration and invasion of ESCC cells, whereas miR-126 inhibitors led to the opposite results. (spandidos-publications.com)
miR-126 suppressed the proliferation, migration and invasion of ESCC cells, and acted as a tumor suppressor in the carcinogenesis of ESCC. (spandidos-publications.com)
miRNAs are involved in biological and pathological processes including cell differentiation, proliferation, apoptosis and metabolism, and they are emerging as highly tissue-specific biomarkers with potential clinical application for defining cancer types and origins. (spandidos-publications.com)
BACKGROUND: MicroRNAs are small, non-coding RNA molecules that regulate important cellular processes such as tumorigenesis, cell proliferation, and apoptosis. (bvsalud.org)
Cancer stem cells are a subset of cells that control metastasis and cell proliferation. (bvsalud.org)
MicroRNAs (miRNAs) are a class of non-coding single-stranded RNA molecules with a length of about 22 nucleotides that regulate various intracellular activities such as cell proliferation, apoptosis and carcinogenesis [ 8 - 10 ] . (researchsquare.com)
It was shown that in pancreatic cells, p27Kip1 and miR-221/222 expression levels inversely correlated and that miR221/222 overexpression had important consequences on the proliferation rate and the cell cycle phase distribution. (biovendor.com)
Moreover, inhibition of miR-222-3p can suppress OS cell proliferation, colony formation, and invasion in vitro. (biovendor.com)
For childhood neoplasms, it is safe to assume that cancer is the product of degeneration in a neoplastic sense of tissues undergoing very rapid proliferation and differentiation, in which proliferative and differentiative programs are being disturbed by increasingly early (maternal-fetal) exposure to a growing number of environmental stressors and pollutants. (frontiersin.org)
They seem unwilling to tell others how the proliferation of viruses links energy theft to the viral microRNAs in cancer cells and in other pathological cell types via alternative splicings. (scentoferos.com)
Importantly, we demonstrate that the overexpression of miR-148a significantly inhibits HCC cell proliferation and cell cycle progression. (spandidos-publications.com)
Since their discovery in 1993, miRNAs have been described in all multicellular organisms and are associated with a vast breadth of biological functions, including cellular proliferation, cellular differentiation and immunity, as well as tissue remodeling and various human diseases, including cancer ( 4 ). (spandidos-publications.com)
The aim of our study was to investigate the role of SNHG3 in the proliferation, migration, and invasion of GC cell lines. (hindawi.com)
CCK-8 and Transwell assays were performed to detect cell proliferation, invasion, and migration abilities. (hindawi.com)
Moreover, lncRNA SNHG3 knockdown or miR-326 overexpression significantly inhibited cell proliferation, migration, and invasion of GC cell lines. (hindawi.com)
In addition, TWIST overexpression can reverse the inhibition of lncRNA SNHG3 knockdown or miR-326 overexpression on cell proliferation, migration, and invasion. (hindawi.com)
They regulate gene expression at the post-transcriptional level and control thereby cellular mechanisms including developmental transitions, organ morphology, apoptosis and cell proliferation. (uni-luebeck.de)
Reduced circ-EPB41 expression in NSCLC decreased cell proliferation and invasion in both in vitro and in vivo experiments. (biomedcentral.com)
Taken togeter, these data revealed the important role of circ-EPB41 in regulating NSCLC cell invasion and proliferation by modifying miR-486-3p/eIF5A axis-mediated stemness. (biomedcentral.com)
growth and apoptosis of NPC cells and assays exposed that miR-21 enhanced NPC cell proliferation JWH 370 and suppressed apoptosis. (biosemiotics2013.org)
STAT3 is normally a well-characterized transcription aspect that is demonstrated to contribute to numerous processes of tumorigenesis such as MUC12 tumor cell survival and proliferation invasion angiogenesis and drug resistance [22]. (biosemiotics2013.org)
MicroRNA-29b-2-5p inhibits cell proliferation by directly targeting Cbl-b in pancreatic ductal adenocarcinoma. (genosensor.co)
Cells must tightly control protein synthesis to maintain homeostasis and regulate proliferation, growth, differentiation, and development. (cshlpress.com)
In response to mito- pendence between the key mecha- gens, cell proliferation is triggered by nistic characteristics. (who.int)
H - Ras cell proliferation are also linked with haematopoietic cel s. (who.int)

A tiny molecule that spurs the progression of non-small-cell lung cancer could become a player in fighting the disease, say researchers at University of Texas Southwestern Medical Center, who published a study on how the molecule behaves in mice in the 14 September issue of Cancer Cell. (myvmc.com)
Dysregulation of miRNAs is frequently associated with disease and, in particular, is involved in prostate cancer progression. (oncotarget.com)
Previous research in other labs showed DUSP3 was involved in the progression and spread of various cancer types, including cervical, prostate and breast cancers. (news-medical.net)
It is currently well recognized that microRNA deregulation is a hallmark of human cancer, and an aberrant expression of these tiny regulatory RNA molecules in several cell types is not just a random association, but it also plays a causal role in different steps of the tumorigenic process, from the initiation and development to progression toward the acquisition of a metastatic phenotype. (nih.gov)
These are measurable molecular indicators found in body fluids or tissues that reveal the presence or progression of cancer. (newspatrolling.com)
It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. (thermofisher.com)
Recently, an increasing number of reports have implicated a new class of small regulatory RNA molecules, termed microRNAs (miRNAs), in HCC progression. (spandidos-publications.com)
The abnormal upregulation of snhg3 in ovarian cancer is closely related to poor prognosis and malignant progression [ 9 ]. (hindawi.com)
MiR-221 and miR-222 (miR-221/222), upregulated in gliomas, can regulate glioma cell cycle progression and apoptosis, respectively. (biomedcentral.com)
The cellular and molecular nature of the TIME influences cancer progression and metastasis by altering the ratio of immune- suppressive versus cytotoxic responses in the vicinity of the tumor. (biomedcentral.com)
Dysregulation of circular RNAs (circRNAs) has recently been found to play an important role in the progression and development of cancers such as non-small cell lung cancer (NSCLC). (biomedcentral.com)
Circ_0002483 has been verified to inhibit NSCLC progression in vivo and in vitro, and increases NSCLC cell sensitivity to Taxol through sponging of miR-182-5p to inhibit expression of FOXO1, FOXO3 and GRB2 mRNAs [ 13 ]. (biomedcentral.com)
The CDK4-cyclinD complex normally phosphorylates the retinoblastoma protein (Rb protein), leading to release of the E2F transcription factor and cell cycle progression. (medscape.com)

abstract = "MicroRNAs (miRNAs) represent a class of naturally occurring small non-coding RNA molecules. (uni-luebeck.de)
This abstract was presented at the BIT's 8th Annual World Cancer Congress, which was held from May 15-17, 2015 in Beijing, China. (ijcto.org)

Overexpression of IRS-1 was associated with cell differentiation, whereas GOLPH3 was related to lymph node metastasis, tumor invasion in-depth and TNM stage in ESCC patients. (spandidos-publications.com)
As part of their ongoing studies, Perera and his colleagues are also looking at how miR-211 might affect other melanoma gene transcripts in ways that promote cancer metastasis and resistance to certain anti-cancer drugs. (news-medical.net)
miRNAs are small, evolutionarily conserved, noncoding RNAs that negatively regulate gene expression and have fundamental roles in cancer growth and metastasis. (biogenex.com)
It has been reported that miR-326 associates with bone metastasis, a biochemical marker of bone turnover in lung cancer, and promotes EMT-induced cellular lung adenocarcinoma infiltration [ 15 ]. (hindawi.com)
reported that miR-326 is abnormally expressed in metastasis and nonmetastasis tissues in non-small-cell lung cancer, providing an experimental basis for exploring the mechanism of non-small cell lung cancer metastasis and molecular diagnosis and treatment [ 16 ]. (hindawi.com)
We detected miR-27a expression in two lung adenocarcinoma cell lines, A549 and A549/CDDP, and then investigated the effects of miR-27a on the metastasis and the chemosensitivity of cancer cells, using both gain- and loss-of-function studies. (biomedcentral.com)
Therefore, chemotherapy-induced EMT in tumor cells has been linked to chemotherapeutic resistance and metastasis. (biomedcentral.com)
Next we explored the roles of miR-27a and its target Raf Kinase Inhibitory Protein (RKIP) in regulating cisplatin resistance and metastasis in lung adenocarcinoma. (biomedcentral.com)
The crosstalk between pro-tumorigenic immune cells, stromal cells, and cytokines helps to establish the pre-metastatic niche for disseminated circulatory tumor cells and facilitates metastasis. (biomedcentral.com)
During metastasis, tumor-derived exosomes help in the requirement and arrangement of immunosuppressive immune cells for favorable premetastatic niche formation and growth of metastases. (biomedcentral.com)
Scientists in Brazil and the United States have reported discoveries regarding a molecule with the potential to combat ovarian cancer and prevent it from spreading to other parts of the body (metastasis). (fapesp.br)
MicroRNA-328 is associated with (non-small) cell lung cancer (NSCLC) brain metastasis and mediates NSCLC migration. (genosensor.co)
Moreover, miR-141 and miR-488 post-transcriptionally regulated androgen receptor (AR) expression, and inhibited the growth and metastasis of prostate gland epithelial cells. (ijcto.org)

Song C, Chen H, Ru G, Ding Q, Yang W. Expression profile analysis of microRNAs in prostate cancer by next-generation sequencing. (ijcto.org)

Promising regulatory molecules in this respect are small non-coding RNAs, like microRNAs, which regulate gene expression post-transcriptionally. (biomedcentral.com)
In particular, CLIP has been used to identify targets of microRNAs, small non-coding RNA molecules that bind to a protein Ago2 and thus regulate gene expression post-transcriptionally. (princeton.edu)

Generally, Perera says, scientists approach their studies of the genetics of melanoma by looking to see which gene and protein products are up- or down-regulated in tumor cells compared with normal skin progenitors. (news-medical.net)
survive in tumor cells before they degrade. (news-medical.net)
The hallmark of GBM is the widespread diffuse invasion of tumor cells into brain tissues. (biomedcentral.com)
Targeting tumor cells or the tumor microenvironment (TME) are the two major fundamental principles for antitumor therapies. (biomedcentral.com)
The oncogenic communication with tumor cells and through the crosstalk of autocrine and paracrine components in almost all tumor types are responsible for this phenomenon. (biomedcentral.com)
The stromal component interacts with tumor cells in complex crosstalk to support tumor growth. (biomedcentral.com)
GEP analyses were performed on highly purified, flow-cytometry sorted tumor-cells from eight subgroups of BCLs. (lu.se)
This enabled identification of TFs that can be uniquely associated to the tumor cells of chronic lymphocytic leukemia (CLL), diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL), hairy cell leukemia (HCL), and mantle cell lymphoma (MCL). (lu.se)
These changes can be inherited and are, therefore, found in every cell, but more often, they are somatically acquired and restricted to tumor cells. (medscape.com)

Recent profiling research suggests that miRNAs are aberrantly expressed in PCa, and these have been implicated in the regulation of apoptosis, cell cycle, epithelial to mesenchymal transition, PCa stem cells, and androgen receptor pathway. (ijcto.org)
These pro- has been implicated as contributing apoptosis, inflammation, and several liferating cel s replace dead cel s to the cancer phenotype, through pleiotropic responses. (who.int)
The TP53 gene is also capable of stimulating apoptosis of cells containing damaged DNA. (medscape.com)

Dysregulation of microRNAs has been confirmed to be involved in cardiac fibrosis development. (hindawi.com)
Causes and consequences of microRNA dysregulation. (nih.gov)
Dysregulation of miRNAs is a common feature in human cancers, but this phenomenon has not been studied extensively in hepatocellular carcinoma (HCC). (spandidos-publications.com)

One particularly important contribution from his lab was the discovery that MYC , a gene that's overactive in many human cancers, promotes cancer in part by reprogramming microRNAs to favor tumor growth. (ascopost.com)
Although SNHG3 has been recognized as a carcinogenic gene in a series of human cancers, the mechanism of SNHG3 in GC remains elusive. (hindawi.com)

MicroRNAs (miRNAs) are small non-coding RNA molecules, approximately 22 nucleotides in length that regulate gene translation through silencing or degradation of target mRNAs. (biovendor.com)

The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
We found that miR-652 directly targets the B" regulatory subunit, PPP2R3A, of the tumor suppressor PP2A, inducing epithelial-mesenchymal transition (EMT) in PC3 cells and neuroendocrine-like differentiation (NED) in LNCaP cells. (oncotarget.com)
Adding microRNA regulation to the network enabled the identification of gene targets of significantly expressed microRNAs after 1,25(OH) 2 D 3 treatment. (biomedcentral.com)
2019) Transcriptome stability profiling using 5'-bromouridine IP chase (BRIC-seq) identifies novel and functional microRNA targets in human melanoma cells. (news-medical.net)
We developed a new algorithm CLIPanalyze for analysis of such data and used it for comprehensive analysis of microRNA targets in vivo in mouse embryonic stem cells, developing embryos, adult tissues and multiple cancer models. (princeton.edu)
The role of these molecules in controlling scarring (fibrosis) may make them targets for EB therapies. (debra.org.uk)
TIME-related RNA or RNA regulators could be promising targets for anticancer immunotherapy. (biomedcentral.com)
Recently, miRNAs have been studied as potential diagnostic or therapeutic targets in cancer treatment. (uni-luebeck.de)
Because many of the microRNA targets we are studying are enriched in various cancers, our work could lead to novel forms of chemotherapy. (pewtrusts.org)
With the technology available at the NIH lab to look for noncoding RNA targets, we discovered that this microRNA also caused cell death by reducing cell energy. (fapesp.br)
11 Chemoresistance, either acquired or intrinsic, is associated with a complicated and multifactorial process, including decreases of intracellular drugs, changes of drug targets, aberrant regulation of cell survival or death, and crosstalks between tumor microenvironment and cancer cells. (dovepress.com)
We also discuss the functional significance of the differentially expressed miRNAs and the molecular pathways/targets regulated by these miRNAs. (ijcto.org)
B-cell lymphomas (BCLs) constitute a diverse set of tially identify new functional, diagnostic, and therapeutic tumors, both morphologically and clinically, that are mainly targets. (lu.se)
Gene signatures and potential therapeutic targets of Middle East respiratory syndrome coronavirus (MERS-CoV)-infected human lung adenocarcinoma epithelial cells. (cdc.gov)

Dr. Muneesh Tewari's project is on the cutting edge of a new technology whereby diagnosis, prognosis and optimal prostate-cancer treatment strategy might be determined by analysis of circulating microRNAs. (fredhutch.org)
Identifying genomic biomarkers for breast cancer prognosis will lead to a better understanding of breast cancer genetics and a more accurate understanding of tumor behavior. (biogenex.com)
Owing to their stability in biological fluids and resistance to various storage conditions, miRNAs are considered as useful biomarkers for cancer diagnosis, prognosis, and prediction of treatment efficacy. (biogenex.com)
The prognosis for lung cancer varies depending on the cancer type, stage at diagnosis, and the patient's overall health. (newspatrolling.com)
Here we are exploring exciting new possibilities in lung cancer, there diagnosis and prognosis - the realm of emerging biomarkers. (newspatrolling.com)
The results showed that the expression of Small Nucleolar RNA Host Gene 3 (SNHG3) was related to the malignant state, and the prognosis was relatively poor. (hindawi.com)
In collaboration with researchers led by Zhi-Ming Shao, a professor at Fudan University Shanghai Cancer Center in China, Kang's team found that breast cancer patients whose tumors expressed large amounts of miR-199a showed poor survival rates, whereas tumors with high levels of LCOR had a better prognosis. (medicalxpress.com)
Background: Vestigial like family member 3 (VGLL3) is associated with the prognosis of epithelial ovarian cancer and soft tissue sarcoma, but its role in gastric cancer (GC) is unclear. (researchgate.net)
Several studies demonstrate important associations between differential expression of micro-RNAs (miRs) and the prognosis of CRC. (biorxiv.org)

This technology could lead to the development of new cancer therapies and other drugs. (udel.edu)
Dr. Gray's research centers on drug development and medicinal chemistry related to targeted therapies for cancer. (ascopost.com)
We're interested in finding therapies that change the activity of these microRNAs," he explained. (ascopost.com)
Promising results will translate into better therapies for patients with advanced prostate cancer. (fredhutch.org)
The use of alternative and adjuvant therapies in pediatric cancer patients appears to be a frequent choice as reported in the reviewed literature. (frontiersin.org)
Advances in medical technology, personalized therapies, and targeted treatments have shown promising results, offering hope for improved outcomes for patients with lung cancer. (newspatrolling.com)
This approach has shown encouraging results in detecting early-stage lung cancer and tracking treatment response, allowing doctors to adjust therapies as needed. (newspatrolling.com)
The study, which will be published in the June issue of Nature Cell Biology , suggests that this "microRNA" promotes particularly deadly forms of breast cancer and that inhibiting the effects of this molecule could improve the efficacy of existing breast cancer therapies. (medicalxpress.com)

Therefore, they may be two gene regulatory points for the prevention of cervical cancer. (researchsquare.com)
We apply these methods to study regulatory genomics of cell function and cell-cell interactions in vivo , with a focus on immunology and cancer. (princeton.edu)
We now continue studying regulatory mechanisms and cell-cell interactions governing CD8 T cell activation and functional commitment across immune challenges in mouse and human using single-cell and spatial multi-omics. (princeton.edu)
Regulatory T (Treg) cells are critical for tolerance to self-antigens and preventing autoimmunity. (princeton.edu)
MicroRNAs (miRNAs) are small regulatory non-coding RNAs, resulting from the cleavage of long primary transcripts (pri-miRNAs) in the nucleus by the Microprocessor complex generating precursors (pre-miRNAs) that are then exported to the cytoplasm and processed into mature miRNAs. (mdpi.com)
If smORFs present within lncRNAs can encode functional small peptides, they can also constitute cis -regulatory elements involved in lncRNA decay. (mdpi.com)
Different regulatory mechanisms can control microRNA expression at a genetic or epigenetic level as well as involve the biogenesis machinery or the recruitment of specific transcription factors. (nih.gov)
The Keane lab will explore how the structural configurations of large RNAs control the production of smaller regulatory RNA molecules. (pewtrusts.org)
Among these regulatory RNAs, microRNAs play critical roles in the control of gene expression. (pewtrusts.org)
These microRNAs are encoded in larger RNA transcripts that must be trimmed to produce the active regulatory molecules. (pewtrusts.org)

MiRNAs are known to control diverse processes including animal development and growth, cell differentiation, signal transduction, cancer disease, virus-induced immune defense, programmed cell death, insulin secretion and metabolism. (usda.gov)
Hormone refractory prostate cancer is often associated with neuroendocrine differentiation (NED) [ 1 ]. (oncotarget.com)
For instance, miR-409-3p promotes epithelial to mesenchymal transition and tumor growth in prostate cancer and also accelerates osteoblastic differentiation through the Wnt/ β -catenin pathway [ 17 , 18 ], a crucial pathway in regulating cardiac fibrosis. (hindawi.com)
What other experimental evidence of biologically-based cause and effect links hydrogen-atom transfer in DNA base pairs from ecological variation to ecological adaptation in all living genera via cell type differentiation in all individuals of all species? (scentoferos.com)
Some tumors, such as triple-negative breast cancers, are particularly deadly because they contain large numbers of cancer stem cells that self-renew and resist differentiation. (medicalxpress.com)
During normal mammary gland development, these cells secrete interferon-alpha to promote cell differentiation and inhibit cell division, the researchers discovered. (medicalxpress.com)
Inevitably, there are fundamental and applied questions, such as those relating to transcriptional control of stem cell differentiation, intrinsic noise in gene expression, and the origins of disease, that may only be addressed at the single cell level. (justia.com)
Transcription factors (TFs) are critical for B-cell differentiation, affecting gene expression both by repres- sion and transcriptional activation. (lu.se)
In this study, highly purified, flow-cytometry sorted, classified in relation to normal B-cell differentiation [1]. (lu.se)
Firstly, we present a robust 2-week protocol for the differentiation of human pluripotent stem cells (PSCs) into forebrain neural progenitor cells. (lu.se)

To do this, the scientists based their sequence inputs on microRNA, small RNA molecules that regulate cellular gene expression. (udel.edu)
To address this, Perera and colleagues used BRIC-seq, a method that tags transcripts with 5-Bromouridine, which is incorporated into newly synthesized RNAs and then can be immunocytochemically analyzed over time without disturbing the rest of the cellular environment. (news-medical.net)
But those safeguards can be turned off by viruses or cancer cells that know how to circumvent natural cellular processes. (scentoferos.com)

The mesenchymal marker N-cadherin increased and epithelial marker E-cadherin decreased in PC3 cells overexpressing miR-652. (oncotarget.com)
LncRNA SNHG3 is also characterized by its involvement in the microRNA pathway of HCC, where miR-128/CD151 signaling of SNHG3 induces epithelial mesenchymal transition (EMT). (hindawi.com)
miR-27a regulates epithelial-mesenchymal transition (EMT) and cisplatin resistance in vitro and modulates response of lung adenocarcinoma cells to cisplatin in vivo . (biomedcentral.com)
Kang and colleagues found that LCOR sensitizes cells to the effects of interferon-signaling molecules released from epithelial and immune cells, particularly macrophages, in the mammary gland. (medicalxpress.com)

NED in prostate cancer has been associated with specific signaling pathways. (oncotarget.com)
Pathway analysis revealed 15 significantly altered pathways: eight more general mostly cell cycle-related pathways and seven cancer-specific pathways. (biomedcentral.com)
One gene, dual specificity phosphatase 3 (DUSP3), regulates important melanoma signaling pathways. (news-medical.net)
Furthermore, RNA-Sequencing and bioinformatic analysis revealed that metabolic pathways are regulated by the KDM. (ntu.ac.uk)
Integration of ChIP-Sequencing with the RNA-Sequencing and metabolic profiling data will reveal the molecular pathways regulated by KDM. (ntu.ac.uk)
Gene Ontology (GO), KEGG, and cancer genomics analyses were performed to identify significant functions, pathways, and the associations of differentially expressed mRNAs. (jcancer.org)
to other RNAs may initiate epige- cleus pathways. (who.int)

miR-616 overexpression has been observed in androgen-independent prostate cancer cells, specifically in malignant tissue compared with benign forms. (wikipedia.org)
However, studies have also reported that aberrant overexpression of miR-126 contributes to carcinogenesis, suggesting that miR-126 acts as an oncogene in gastric cancer and oral squamous cell carcinoma ( 16 , 17 ). (spandidos-publications.com)
Overexpression of miR-652 in prostate cancer cells, PC3 and LNCaP, resulted in increased growth, migration and invasion. (oncotarget.com)
In LNCaP cells and xenografted tumors, overexpression of miR-652 increased markers of NED, including chromogranin A, neuron specific enolase, and synaptophysin. (oncotarget.com)
In addition, several studies indicate that miR-221/222 have a prominent role in acquisition of anti-estrogen resistance and that miR221/222 overexpression is linked to altered response to cancer therapy, either to hormone-based or to conventional chemotherapy. (biovendor.com)
The tumorigenic process implies a substantial alteration of these mechanisms, thus disrupting the equilibrium within the cell and leading to a global change in microRNA expression, with loss of oncosuppressor microRNAs and overexpression of oncomiRNAs. (nih.gov)
Additionally, DNMT1, the DNA methyltransferase that maintains methylation patterns, is aberrantly upregulated in HCC cell lines, and its overexpression is responsible for hypermethylation of the miR-148a promoter. (spandidos-publications.com)
Small interfering RNA-mediated RKIP knockdown revealed similar effects as that of ectopic miR-27a expression, while overexpression of RKIP attenuated the function of miR-27a in lung adenocarcinoma cells. (biomedcentral.com)
Conversely, overexpression of miR-1/133a caused the cells to terminate any cell division activity if we had previously induced it by administering the binding molecules of the two receptors, i.e. oncostatin and FGF,' explains Melissa Valussi, first author of the study. (mpg.de)

Dr. Gray is the Nancy Lurie Marks Professor of Biological Chemistry and Molecular Pharmacology at Harvard Medical School and the Dana-Farber Cancer Institute. (ascopost.com)
These molecules appear to be cancer-specific and hold great promise for molecular profiling of tumors. (fredhutch.org)
Dr Eric Olson, chairman of molecular biology at UT Southwestern and the study's senior author, said the experiments also show that deleting miR-21 sensitizes the animals' cancer cells to a certain kind of chemotherapy, suggesting that inhibiting miR-21 in lung-cancer patients could be of therapeutic value. (myvmc.com)
The molecular mechanism of Wnt signaling underlying the development of ovarian cancer, drug resistance, and relapse is not completely understood. (edu.au)
Breast cancer represents a heterogeneous group of tumors characterized by a wide range of clinical, pathologic and molecular features. (biogenex.com)
Aim 2: To characterize the molecular mechanisms regulated by KDM. (ntu.ac.uk)
Better molecular characterization of CD8 T cells in different contexts is fundamentally important and can lead to improved clinical results in cancer immunotherapies, infectious diseases, autoimmunity. (princeton.edu)
In this review we deal in the molecular mechanisms, the epigenetic effects and modulation of the oxidative stress pathway of ketogenic diets, that underlie its possible role, in the treatment of infantile gliomas, as a complementary approach to conventional cancer therapy. (frontiersin.org)
In 1995, she moved to the Istituto Dermopatico dell'Immacolata (IDI), where she was Director of the Laboratory of Molecular and Cell Biology (1995-2015) and then Scientific Director (2017-2018). (debra.org.uk)
Using techniques in molecular and structural biology combined with a method I developed for monitoring the structure of large RNA molecules, my lab will elucidate the conformational "switch" that directs the processing of microRNAs encoded on large primary transcripts. (pewtrusts.org)
Researchers from Princeton University's Department of Molecular Biology have identified a small RNA molecule that helps maintain the activity of stem cells in both healthy and cancerous breast tissue. (medicalxpress.com)
Thus, it is an essential reference for cell and molecular biologists, as well as cancer biologists and all those investigating human diseases associated with translation dysfunction. (cshlpress.com)
The Potential Bioactive Components of Nine TCM Prescriptions Against COVID-19 in Lung Cancer Were Explored Based on Network Pharmacology and Molecular Docking. (cdc.gov)

Additionally, we will explore the post-transcriptional regulation of KDM based on our microRNA preliminary data using western blot, RT-qPCR and 3'UTR reporter assays. (ntu.ac.uk)
We show that human and chimpanzee cells differentiate in a similar man¬ner and that the difference in interspecies protein abundance is higher than transcript-level differences, suggesting that post-transcriptional mechanisms play a role in the difference between human and chim¬panzee brain development. (lu.se)

It has been suggested that abnormal expression of microRNAs (miRNAs) is associated with carcinogenesis. (spandidos-publications.com)
In addition, they examined the expression of microRNAs in these cells upon treatment with 1,25(OH) 2 D 3 . (biomedcentral.com)

Extracellularly secreted Wnt signaling inhibitors are crucial regulators of ovarian cancer tumorigenesis and malignant properties of cancer stem cells. (edu.au)
miR-17 has been linked to tumorigenesis in a broad range of cancers, including gastric cancer (2), and colon cancer (3). (biogenex.com)
A recent demonstration of the differential expression of miRNAs and their target mRNAs in cancer and the discovery that some miRNAs can function as oncogenes or tumor suppressors have sparked considerable interest in elucidating their role in tumorigenesis ( 5 , 6 ). (spandidos-publications.com)
The microRNA plays a similar role during tumorigenesis, protecting breast cancer stem cells from the effects of interferons secreted by immune cells present in the tumor. (medicalxpress.com)

We review the main mechanisms regulating microRNAs and the consequences of their aberrant expression in cancer, with a glance at the possible implications at a clinical point of view. (nih.gov)
To better understand the biological mechanisms of chemoresistance in lung adenocarcinoma cells and search for the reversion opportunities, we made use of a cisplatin-sensitive and derived resistant lung cancer cell line pair (A549 and A549/ CDDP). (biomedcentral.com)
The present study is to investigate the role of microRNA-21 (miR-21) in nasopharyngeal carcinoma (NPC) and the mechanisms of regulation of PTEN by miR-21. (biosemiotics2013.org)
Cancer-associated fibroblasts (CAFs) have been demonstrated to be essential stromal components in the tumor microenvironment, regulating cancer cell growth, migration, invasion, and chemo-response through various mechanisms. (dovepress.com)

MiR-222 and miR-221 are two highly homologous microRNAs located in tandem on the X chromosome in human, mouse and rat and are highly conserved in vertebrates. (biovendor.com)

We are now studying the role of Foxp3 and other factors in chromatin organization and gene expression regulation in functionally heterogeneous Treg cells across tissues. (princeton.edu)
It has been demonstrated that miR-222-3p was upregulated in OS tissues and OS cell lines. (biovendor.com)
Stem cells give rise to the different cell types in adult tissues but, in order to maintain these tissues throughout adulthood, stem cells must retain their activity for decades. (medicalxpress.com)
Results: Analysis of the ONCOMINE and GEPIA databases showed that VGLL3 was significantly up-regulated in GC tissues (P = 0.003), and associated with the tumor TNM stage (P = 0.0163). (researchgate.net)
The results show that the circ-EPB41 was upregulated in NSCLC tissues and cell lines. (biomedcentral.com)

Esophageal squamous cell carcinoma (ESCC) is a common histologic subtype in China. (spandidos-publications.com)
Although Barrett's adenocarcinoma is the most rapidly increasing cancer in Western countries, esophageal squamous cell carcinoma (ESCC) remains dominant in East Asia ( 3 ). (spandidos-publications.com)

Ovarian cancer is a fatal malignancy in women with a low survival rate that demands new therapeutic paradigms. (edu.au)
As the third leading cause of cancer death, HCC accounts for 85-90% of all primary liver cancers and ranks as the fifth most prevalent malignancy worldwide ( 1 ). (spandidos-publications.com)
Gastric cancer (GC) is a common malignancy in the world [ 1 ]. (hindawi.com)

Long noncoding RNA (lncRNA) is more than 200 nucleotides in length without significant protein-coding potential [ 5 ]. (hindawi.com)

Therefore a further understanding of the evolutionary processes underlying resistance formation is crucial for developing effective treatments that are able to overcome resistance and cancer relapse. (southcoastbiosciencesdtp.ac.uk)
Moreover, after 1,25(OH) 2 D 3 treatment the gene expression in several cancer-related processes was down-regulated. (biomedcentral.com)
2011 ) clearly showed that 1,25(OH) 2 D 3 can modulate gene and microRNA profiles in LCNaP cells and affects processes involved in cell cycle arrest, calcium ion homoeostasis and phosphoinositide-mediated signalling. (biomedcentral.com)
MicroRNAs (miRNAs) have been identified as important posttranscriptional regulators involved in various biological and pathological processes of cells, but their association with tumor chemoresistance has not been fully understood. (biomedcentral.com)
This triggered intracellular processes, at the end of which cell division was initiated in the cardiac muscle cells. (mpg.de)
for example they can be important in regulating processes such as cell growth, organ formation and cell death. (lu.se)

The small RNA transcriptomes obtained in this study uncovers the differentially expressed miRNAs, and provides a better understanding of the expression and function of miRNAs in the development of PCa and reveals several miRNAs in PCa that may have biomarker and therapeutic potentials. (ijcto.org)

In addition, several miRNAs were shown to influence sensitivity to chemo- or radiotherapy: miRNAs of the Let-7 family induced radiosensitivity in vitro/in vivo, inhibition of miR-21 and miR-200b increased sensitivity to gemcitabine in cholangiocarcinoma cell lines, and restoration of miR-34 in p53-deficient human gastric cancer cells induced chemosensitisation. (uni-luebeck.de)

MiR-222-3p was conﬁrmed to exhibit higher expression level in oral squamous cell carcinoma (OSCC). (biovendor.com)
It is responsible for mitten hand formation, limb contractures and mucosal strictures, and is implicated in the development of early and aggressive skin squamous cell carcinoma. (debra.org.uk)
4 As the primary type of lung cancer, non-small cell lung cancer (NSCLC) exhibits multiple histological types, such as bronchoalveolar carcinoma, large cell carcinoma, squamous cell carcinoma, and adenocarcinoma. (dovepress.com)

Brain tumors account for 20-25% of pediatric cancers. (frontiersin.org)
Glioblastomas are intrinsic brain tumors believed to originate from neuroglial stem or progenitor cells. (frontiersin.org)
The carcinogens present in tobacco smoke damage the cells lining the lungs, leading to the development of cancerous tumors over time. (newspatrolling.com)
Many tumors also contain so-called " cancer stem cells " that can drive tumor formation. (medicalxpress.com)
Just as boosting miR-199a levels helped normal mammary gland stem cells retain their activity, the researchers showed that miR-199a enhanced the ability of cancer stem cells to form tumors. (medicalxpress.com)
Sex cord-stromal tumors are groups of tumors composed of granulosa cells, theca cells, Sertoli cells, Leydig cells, and fibroblasts of stromal origin, singly or in various combinations. (medscape.com)
A worldwide database analysis revealed that younger age, smaller tumor size, early stage, and granulosa cell tumor histologic type appear to be independent prognostic factors for improved survival in patients with malignant sex cord-stromal tumors who undergo lymph node dissection. (medscape.com)
Impact of TMPRSS2 Expression, Mutation Prognostics, and Small Molecule (CD, AD, TQ, and TQFL12) Inhibition on Pan-Cancer Tumors and Susceptibility to SARS-CoV-2. (cdc.gov)
An important development in cancer research over the past 2 decades has been the recognition that genetic changes drive the pathogenesis of tumors of both adulthood and childhood. (medscape.com)

MicroRNAs (miRNAs) are small non-coding RNAs (20 to 24 nucleotides) that post-transcriptionally modulate gene manifestation by negatively regulating the stability or translational effectiveness of their target mRNAs [6]. (biosemiotics2013.org)
MicroRNAs (miRNAs) are small single stranded non-coding RNA molecules (~22 nucleotides) which impede protein production by directly interacting with 3'-untranslated regions of the target mRNAs. (ijcto.org)

MicroRNAs (miRNAs) are non-coding RNAs that block protein production by interacting with specific mRNAs. (debra.org.uk)
The expression profiles of long noncoding RNAs (lncRNAs) and mRNAs of PEX-treated dendritic cells are unknown. (jcancer.org)

We develop computational methods for design and analysis of high-throughput functional genomic assays and perturbations, with a focus on multi-modal single-cell, spatial and genome editing technologies. (princeton.edu)
To facilitate the use of this technology, especially in the noncoding genome and for batch screens, we developed GuideScan , a fully customizable CRISPR guide RNA (gRNA) design tool . (princeton.edu)
We now continue working on tools for design and analysis of CRISPR-based genome perturbations and their combinations with single-cell functional genomic assays. (princeton.edu)
International Cancer Genome Consortium. (cancerindex.org)
Microfluidic devices employing active valving to position and isolate cells have allowed for the isolation and genome amplification of individual microbial cells (32). (justia.com)
ing of microRNAs to the genome or inside the cel via membrane-to-nu- 2011 ). (who.int)

Today's dominant paradigm in the field of carcinogenesis can be described as stochastic mutational, a model where cancer is ultimately viewed as the product of a slow accumulation of stochastic DNA mutations. (frontiersin.org)
These data clearly implicated that miR-21 acted as a key molecule in carcinogenesis. (biosemiotics2013.org)

Wnt signaling is an evolutionarily conserved signaling cascade that has been shown to regulate ovarian cancer pathogenesis. (edu.au)
Given the importance of Wnt signaling in ovarian cancer, more systematic studies combined with clinical studies are requisite to probe the precise mechanistic interactions of Wnt antagonists in ovarian cancer. (edu.au)
This review outlines the latest progress on the Wnt antagonists and ovarian cancer-specific regulators such as micro-RNAs, small molecules, and drugs regulating these Wnt antagonists in ovarian tumourigenesis. (edu.au)
It's a promising molecule that can be the basis for future therapeutic strategies against ovarian cancer using nanotechnology," Wilson Araújo da Silva Junior , a researcher affiliated with CTC and principal investigator for the study, told Agência FAPESP . (fapesp.br)
Ovarian cancer is initially asymptomatic and often goes undetected until it is already at an advanced stage. (fapesp.br)

yet, little attention has been given to the roles of miRNAs in non-model species including fishes. (usda.gov)
In this study, we focus on the roles of miR-10b, miR-21 and correlate with cancer stem cells through the apoptotic pathway in different stages of prostate cancer (PCa). (bvsalud.org)
As might be expected from molecules with these roles, miRNAs are involved in cancer development, and deregulation of several miRNAs has been found in various cancer types. (uni-luebeck.de)
The roles of the endoplasmic reticulum, the unfolded protein response, processing bodies (P-bodies), stress granules, and small RNAs are also covered. (cshlpress.com)

microRNA profiling revealed potential regulators of the KDM, and preliminary in vitro functional studies propose an oncogenic role of KDM in liver cancer. (ntu.ac.uk)

Colorectal cancer (CRC) is a leading cause of death and is annually responsible for more than 500,000 deaths worldwide. (iiarjournals.org)
SNHG3 is a new type of lncRNA, which may be related to Alzheimer's disease and colorectal cancer. (hindawi.com)
Colorectal cancer (CRC) is a multifactorial disease commonly diagnosed worldwide, with high mortality rates. (biorxiv.org)
The studies investigated the expression of 102 different miRs associated with prognostic aspects in colorectal cancer patients. (biorxiv.org)
Colorectal cancer (CRC) is one of the most prevalent neoplasms in the world, being the second type of cancer more frequent in women and the third type more frequent in men. (biorxiv.org)
In Brazil, for the 2018-2019 biennium, it is estimated the occurrence of 36.030 new colorectal cancer cases with 17.380 cases in men and 18.980 cases in women 1 . (biorxiv.org)

We have screened 182 small molecule epigenetic modulators on liver cancer cells and found that inhibitors of a specific histone demethylase (KDM) induce cell death. (ntu.ac.uk)
Herein, we describe the epigenetic regulation of miR-148a and its impact on HCC cells. (spandidos-publications.com)
Activating mutations upstream may also underlie some epigenetic or within the ERK1/2 cascade are events that change cell signalling. (who.int)
More so, our results show that the epigenetic regulation of TE transcription is dynamically regulated throughout life (Paper II), upon the beginning of neuroinflammation (Paper III), and in a disease-driving polymorphic TE insertion (Paper IV). (lu.se)

Understanding the mechanism underlying the role of tumor stroma, especially cancer-associated fibroblasts (CAFs), during chemoresistance would significantly contribute to the clinical application of chemotherapy agents. (dovepress.com)

1 In 2018, approximately 2.09 million new lung cancer cases took place, ranking first in all cancer types. (dovepress.com)

Cancer prodrugs are inactive until they are metabolized into their therapeutic form. (udel.edu)
Aim 3: To explore the therapeutic potential of KDM inhibition in liver cancer. (ntu.ac.uk)
Targeting or activating the TIME components show a promising therapeutic avenue to combat cancer. (biomedcentral.com)
It clearly has therapeutic implications for designing strategies to rationally target the breast cancer stem cells with immune modulators. (medicalxpress.com)
This volume includes discussion of translational deregulation in cancer and the development of therapeutic agents that target translation initiation. (cshlpress.com)

The fact that cancer increases especially in the early years of life is something unexpected and difficult to explain with the model of slow accumulation of stochastic mutations. (frontiersin.org)
Inactivating mutations and deletions of the PTEN gene are found in many types of cancers including NPC [26]. (biosemiotics2013.org)

Cells, of course, already know how to sense toxic molecules and the development malignant tendencies, and to then take action. (scentoferos.com)
This is a very nice study linking a normal and malignant mammary gland stem cell program to protection from immune modulators," said Michael Clarke, the Karel H. and Avice N. Beekhuis Professor in Cancer Biology at Stanford School of Medicine, Institute of Stem Cell Biology and Regenerative Medicine, who first discovered breast cancer stem cells but was not involved in this study. (medicalxpress.com)
C: Tumor either Stage IA or Stage IB, but with tumor on the surface of one or both ovaries, or with capsule ruptured, or with ascites containing malignant cells or with positive peritoneal washings. (medscape.com)
or ascites present containing malignant cells or with positive peritoneal washings. (medscape.com)

miR-616 has been found to induce the specifically androgen-independent growth of prostate cancer cells. (wikipedia.org)
The Prostate Cancer Foundation has announced that it has funded 10, $100,000 Creativity Awards for advanced prostate cancer research. (fredhutch.org)
Tewari will optimize the isolation of exosomes and purification of microRNAs from prostate cancer models followed by genetic probing of these materials. (fredhutch.org)
These awards feed our pipeline of compelling ideas to cultivate new solutions for the prostate cancer problem. (fredhutch.org)
Read more about prostate cancer and the PCF at www.pcf.org . (fredhutch.org)
Adapted from a Prostate Cancer Foundation news release. (fredhutch.org)
High expression of one of these five miRNAs, miR-652, correlated significantly with an increased rate of prostate cancer biochemical recurrence. (oncotarget.com)
Prostate cancer cell xenografts overexpressing miR-652 showed increased tumorigenicity and metastases. (oncotarget.com)
MiR-652 expression could serve as a biomarker for aggressive prostate cancer, as well as provide an opportunity for novel therapy in prostate cancer. (oncotarget.com)
Several studies suggest that activation of the Wnt pathway promotes NED of prostate cancer cells [ 7 , 8 ]. (oncotarget.com)
The present study explores the role of the biologically active form of vitamin D3, 1,25-dihydroxyvitamin D 3 (1,25(OH) 2 D 3 ), in prostate cancer. (biomedcentral.com)
Several studies suggest that adequate vitamin D levels have a protective effect with respect to the development of prostate cancer, and it is believed that vitamin D has chemopreventive properties. (biomedcentral.com)
In the Gene Expression Omnibus (GEO, http://ncbi.nlm.nih.gov/geo/ , Barrett and Edgar 2006 ), we found two studies in which global gene expression was measured in 1,25(OH) 2 D 3 -treated prostate cells, accession numbers: GSE17461 and GSE15947. (biomedcentral.com)
Screen Targeting Lung and Prostate Cancer Oncogene Identifies Novel Inhibitors of RGS17 and Problematic Chemical Substructures. (nih.gov)
Prostate cancer (PCa) is the second leading cause of tumor mortality among males in western societies. (ijcto.org)

Indeed, aberrant translational control is associated with cancer, several neurologic syndromes, and a group of genetic disorders termed "ribosomopathies. (cshlpress.com)

They have called their tool iSHiRLoC, or "intracellular single molecule, high-resolution localization and counting. (umich.edu)
Existing methods for measuring transcript levels in single cells include RT-qPCR (1), single molecule counting using digital PCR (2) or hybridization probes (3, 4), and next generation sequencing (5). (justia.com)

Cross-linking immunoprecipitation followed by sequencing (CLIP-seq) is a family of methods for profiling sites of protein binding to RNA. (princeton.edu)
Luciferase reporter gene analysis and RNA immunoprecipitation (RIP) analysis confirmed the interaction between lncRNA SNHG3, miR-326, and TWIST. (hindawi.com)

In fact, at 18 weeks of age, the study group with overexpressed miR-21 had significantly more tumours than their lung-cancer-carrying littermates with normal levels of miR-21. (myvmc.com)
Studies have shown that the expression of miR-126 is downregulated in cancers such as non-small cell lung cancer and colon cancer ( 14 , 15 ), suggesting that the downregulation of miR-126 is significantly related to the occurrence and development of cancer. (spandidos-publications.com)
miR-27a was significantly up-regulated in cisplatin-resistant lung adenocarcinoma A549/CDDP cells compared with parental A549 cells. (biomedcentral.com)
In this study, we observed that miR-27a is significantly upregulated in cisplatin-resistant human lung adenocarcinoma A549/CDDP cells compared with parental A549 cells. (biomedcentral.com)
In this study, we demonstrated that NSCLC-derived CAFs were innately resistant to cisplatin treatment and CAFs-conditioned medium significantly promoted the survival rate of NSCLC cells after cisplatin treatment. (dovepress.com)

However, the association of miR-221/222 with glioma cell invasion and survival remains unknown. (biomedcentral.com)
Over-expression of miR-221/222 increased cell invasion, whereas knockdown of miR-221/222 decreased cell invasion via modulating the levels of the target, TIMP3. (biomedcentral.com)
Introduction of a TIMP3 cDNA lacking 3' UTR abrogated miR-221/222-induced cell invasion. (biomedcentral.com)
The present data indicate that miR-221 and miR-222 directly regulate cell invasion by targeting TIMP3 and act as prognostic factors for glioma patients. (biomedcentral.com)
However, there is little direct evidence to show the mechanism by which miR-221/222 controls glioma invasion. (biomedcentral.com)
Furthermore, knockdown of miR-221/222 decreased invasion capability, reduced tumor growth and up-regulated the expression of the target, TIMP3, whereas ectopic expression of miR-221/222 exhibited the opposite effects. (biomedcentral.com)

MicroRNAs (miRNAs) are tiny RNA molecules that play a crucial role in regulating gene expression. (newspatrolling.com)

In this paper, we've shown that we have the tools with which we can actually see single miRNAs in cells, and we can look at their movement from nucleus to cytoplasm and cytoplasm to nucleus," Walter said. (umich.edu)
Circular RNAs (circRNAs) belong to a class of noncoding and protein-coding RNAs localized to the cytoplasm which originate from both single and multiple exons [ 7 , 8 ]. (biomedcentral.com)

Scientists have known that the molecule microRNA-21, or miR-21, is present in overabundant quantities in human tumours, including non-small-cell lung cancer (NSCLC). (myvmc.com)
Until now, however, it was unclear whether miR-21 contributed to the development of lung cancer, or whether it was simply an indicator of the presence of the disease. (myvmc.com)
To find out, lead study author Dr Mark Hatley, an instructor of paediatric haematology/oncology, and UT Southwestern colleagues used mice that had been altered specifically to harbor non-small-cell lung cancer. (myvmc.com)
Instead, it appears that miR-21 enhances the growth and survival of existing lung cancer,' said Dr Hatley, a Pediatric Scientist Development Program Fellow sponsored by the Eunice Kennedy Shriver National Institute of Child Health and Human Development. (myvmc.com)
These results were then confirmed in glioblastomas, in thyroid papillary carcinomas, in breast cancer, hepatocellular carcinoma, and lung cancer. (biovendor.com)
Lung cancer, a devastating disease that affects millions worldwide, is primarily caused by prolonged exposure to harmful substances. (newspatrolling.com)
Smoking is the most significant risk factor, accounting for the majority of lung cancer cases. (newspatrolling.com)
However, non-smokers can also develop lung cancer due to exposure to secondhand smoke, air pollution, radon gas, asbestos, and other occupational hazards like certain chemicals and minerals. (newspatrolling.com)
The symptoms of lung cancer often manifest in the later stages of the disease, which makes early detection challenging. (newspatrolling.com)
Sometimes, lung cancer may cause symptoms outside the respiratory system, such as bone pain, headaches, and neurological issues if the cancer has spread to other parts of the body. (newspatrolling.com)
Diagnosing lung cancer typically involves a combination of imaging tests, such as chest X-rays and CT scans, and tissue sampling through biopsies. (newspatrolling.com)
These biomarkers hold the potential to transform lung cancer management, offering early detection, personalized treatment approaches, and better outcomes for patients. (newspatrolling.com)
Conventional diagnostic methods for lung cancer, such as imaging and tissue biopsies, have been useful but not without limitations. (newspatrolling.com)
One of the most promising types of emerging biomarkers for lung cancer is circulating tumor DNA (ctDNA). (newspatrolling.com)
When cancer cells die, they release DNA into the bloodstream, and ctDNA can be detected and analyzed to identify specific genetic changes associated with lung cancer. (newspatrolling.com)
In lung cancer, specific miRNAs have shown potential as diagnostic and prognostic biomarkers. (newspatrolling.com)
Immunotherapy has transformed cancer treatment, and lung cancer has benefited from these advances. (newspatrolling.com)
These results indicate that tumor suppresses the function of miR-326 in lung cancer. (hindawi.com)
Our results suggest that up-regulation of miR-27a could suppress RKIP expression and in turn contribute to chemoresistance of lung adenocarcinoma cells to cisplatin. (biomedcentral.com)
Lung cancer (LC) is among the most prevalent cancers, and its prevalence is a major factor affecting cancer mortality worldwide. (biomedcentral.com)
miR-1254 and miR-574-5p: serum-based microRNA biomarkers for early-stage non-small cell lung cancer. (genosensor.co)
Chemoresistance is a significant barrier to the treatment and management of non-small cell lung cancer (NSCLC). (dovepress.com)
Lung cancer has emerged as the leading cause of cancer-associated deaths worldwide, accounting for about 20% of all cancer deaths. (dovepress.com)
2 , 3 In China, lung cancer mortality is higher than in most other countries, and it is estimated that lung cancer mortality may surge nearly 40% between 2015 and 2030. (dovepress.com)
Scientists from Thomas Braun's department at the Max Planck Institute for Heart and Lung Research in Bad Nauheim have now been able to show in mice that one such mechanism involves two so-called micro-RNAs, miR-1 and miR-133a. (mpg.de)
Repurposing Methotrexate in Dampening SARS-CoV2-S1-Mediated IL6 Expression: Lessons Learnt from Lung Cancer. (cdc.gov)

Primary liver cancer mainly refers to hepatocellular carcinoma (HCC), cholangiocarcinoma and hepatic angiosarcoma. (spandidos-publications.com)

Anatomy13

Organisms9

Diseases21

Chemicals and Drugs99

Analytical, Diagnostic and Therapeutic Techniques and Equipment38

Phenomena and Processes74

Disciplines and Occupations2

Information Science6

Health Care3

Genes45

Proteins22

MiRNA29

Endogenous4

MRNA9

Proliferation26

Progression13

Abstract2

Metastasis13

Analysis of microRNAS1

Gene expression post-transcriptionally2

Tumor cells9

Apoptosis3

Dysregulation3

Human cancers2

Approximately 22 nucleotides1

Targets14

Prognosis9

Therapies8

Regulatory10

Differentiation10

Cellular3

Epithelial4

Pathways7

Overexpression9

Molecular13

Post-transcriptional2

Expression of microRNAs2

Tumorigenesis4

Mechanisms4

Highly conserved1

Tissues5

Esophageal squamous cell carc2

Malignancy3

Nucleotides in length1

Processes6

Differentially expressed1

Gastric1

Squamous3

Tumors9

Target mRNAs2

MRNAs2

Genome6

Carcinogenesis2

Ovarian Cancer5

Roles4

Regulators1

Colorectal cancer6

Epigenetic4

Chemotherapy1

20181

Therapeutic5

Mutations2

Malignant4

Prostate15

Translational1

Single molecule2

Immunoprecipitation2

Significantly5

Invasion6

Role in regulating gene1

Cytoplasm2

Lung26

Carcinoma1