• 8. Selenocystine-induced cell apoptosis and S-phase arrest inhibit human triple-negative breast cancer cell proliferation. (nih.gov)
  • 16. Genistein and daidzein induce cell proliferation and their metabolites cause oxidative DNA damage in relation to isoflavone-induced cancer of estrogen-sensitive organs. (nih.gov)
  • Cancer cells exhibit three characteristics that are linked directly to genome duplication: genome instability, unregulated cell proliferation, and resistance to apoptosis. (nih.gov)
  • Unregulated proliferation means that cancer cells duplicate their genome much more frequently than normal cells do, and therefore increase the risk of genome instability and genetic mutations. (nih.gov)
  • Unregulated proliferation results from increased sensitivity of cancer cells to mitogenic stimuli and decreased sensitivity to contact inhibition. (nih.gov)
  • The tumor suppressor genes Retinoblastoma (Rb) and TP53 are the cell proliferation control genes whose activities are most frequently altered in cancers (1). (nih.gov)
  • TP53 regulates expression of genes that either arrest cell proliferation or trigger apoptosis. (nih.gov)
  • We evaluated DNA damage following BPA exposure using the comet assay and immunofluorescence staining, and used cell counting and three-dimensional cultures to evaluate effects on proliferation. (nih.gov)
  • Low-dose BPA significantly promoted DNA damage, up-regulated c-Myc and other cell-cycle regulatory proteins, and induced proliferation in parallel in estrogen receptor-α (ERα)-negative mammary cells. (nih.gov)
  • Silencing c-Myc diminished these BPA-induced cellular events, suggesting that c-Myc is essential for regulating effects of BPA on DNA damage and proliferation in mammary cells. (nih.gov)
  • the molecular mechanisms underlying low-dose BPA-mediated regulation of proliferation and DNA damage in ERα-negative breast cells are largely unknown. (nih.gov)
  • Cell proliferation, migration, colony formation, and cell cycle assays were performed along with analysis of a nude mouse tumorigenesis model to explore RAB20's oncogenic functions. (researchsquare.com)
  • This study has revealed the ability of ruthenium complexes to inhibit cell proliferation, induce cell cycle progression and apoptosis. (biomedcentral.com)
  • Here we mimicked the lymph node microenvironment using CD40 ligand (CD40L)-expressing stroma and interleukin-21 (IL-21) to find that inducing proliferation of the primary CLL cells conferred enhanced sensitivity to NAE inhibition. (elsevierpure.com)
  • The cytotoxicity was examined using cell proliferation and acridine orange/ethidium bromide (AO/EB) assay. (hindawi.com)
  • In this study, we found that the addition of CHKi to the EGFR inhibitor cetuximab with and without radiotherapy significantly decreased cell proliferation and survival fraction in human papillomavirus virus (HPV)-positive and HPV-negative HNSCC cell lines. (aacrjournals.org)
  • Reduced proliferation was accompanied by decreased checkpoint activation, induced S-phase accumulation, persistent DNA damage, and increased caspase cleavage and apoptosis. (aacrjournals.org)
  • The model has four outcomes that convey alternative cell fates: proliferation, (transient) cell cycle arrest, apoptosis and senescence. (biomedcentral.com)
  • These enzymes regulate acetylation of histone and non-histone proteins, and thereby control key cellular processes including cell cycle progression, proliferation, survival, DNA repair and differentiation [6,7]. (acp2018.org)
  • Knock down of ZFP57 in OC cells inhibited the cell proliferation and migration, and also arrested the cells at G1 phase as well as accelerated the apoptosis. (jcancer.org)
  • Numerous studies confirmed that deguelin activated the virus signaling pathway for inhibiting tumor cell proliferation with no or less toxicity ( 5 - 8 ), while demonstrating the highest activity in inhibiting DMBA-induced tumorigenesis compared with tephrosin, 13α-hydroxytephrosin and 13α-hydroxydeguelin. (spandidos-publications.com)
  • Apoptosis is a crucial step in cancer therapy and prevention, whereby cells undergo programmed death to eliminate the damaged and harmful cells and restrict cell proliferation. (spandidos-publications.com)
  • Certain lncRNAs are involved in important biological processes in cancer development through the regulation of target genes, including DNA methylation, histone modification and chromatin remodeling ( 13 ), and have considerable roles in the processes of proliferation, migration and invasion in a variety of tumors, which are closely related to treatment strategies and prognoses of these patients. (spandidos-publications.com)
  • For instance, lncRNA hypoxia-inducible factor 1α-antisense 2 (AS2) is an oncogenic KRAS-inducible lncRNA and its high expression may promote lung cancer cell proliferation and tumor metastasis ( 14 ). (spandidos-publications.com)
  • PLK4 inhibition also prevents cell division and inhibits proliferation of PLK4-overexpressing tumor cells. (nih.gov)
  • Upon oral administration, ibcasertib binds to and inhibits the activity of aurora B, VEGFRs, c-kit and PDGFRs, which may result in a decrease in the proliferation of tumor cells that overexpress these kinases. (nih.gov)
  • Upon intravenous administration, cifurtilimab binds to CD40 on a variety of immune cell types, triggering both cellular proliferation and activation of antigen-presenting cells (APCs), which activates B-cells and T-cells, and enhances the immune response against tumor cells. (nih.gov)
  • In addition, this agent binds to the CD40 antigen present on the surfaces of tumor cells, which induces antibody-dependent cytotoxicity (ADCC), and eventually inhibits the proliferation of CD40-expressing tumor cells. (nih.gov)
  • Indeed, depletion of PLK1 gene expression outcomes in inhibition of proliferation as a result of accumulation in the mitotic phase and apoptosis induction in tumor cell lines [7, 8]. (achrinhibitor.com)
  • Tumor microenvironment (TME) Oncology research solutions TABLE OF CONTENTS Molecular drivers of cancer pathogenesis Cancer progression is associated with the interplay between tumor cells and the surrounding environment, which requires signal transduction pathways to relay messages throughout the cell.1,2 Cell signaling pathways regulate everything from cell growth to proliferation to survival. (technologynetworks.com)
  • Many of the genes commonly mutated encode Purpose and scope INTRODUCTION components or targets of the PI3K/AKT and Ras/ERK pathways, causing dysregulation of cellular signaling.1 This dysregulation drives cancer progression by influencing the behavior of tumor cells through cell proliferation, survival, migration, differentiation, metabolism, polarity, angiogenesis, and the tumor microenvironment. (technologynetworks.com)
  • Cell proliferation assay was performed by MTT Cell cycle, ROS levels and apoptosis were analyzed by flow cytometry, protein levels were detected by Western Blotting. (biomedcentral.com)
  • Cell treatment with Valproic Acid reduced cell proliferation and induced G0/G1 cell cycle arrest in MCF-7 and G2/M block in MDA-MB-231 cells. (biomedcentral.com)
  • Cell viability detection results indicated that APS can inhibit the proliferation of human lung cancer cell line A549 and NCI-H358 in the concentration of 20 and 40 mg/mL. (biomedcentral.com)
  • 1. Quantitative phosphoproteomics reveals genistein as a modulator of cell cycle and DNA damage response pathways in triple-negative breast cancer cells. (nih.gov)
  • 2. Genistein induces G2/M cell cycle arrest and apoptosis of human ovarian cancer cells via activation of DNA damage checkpoint pathways. (nih.gov)
  • 7. Inverse agonist of estrogen-related receptor α suppresses the growth of triple negative breast cancer cells through ROS generation and interaction with multiple cell signaling pathways. (nih.gov)
  • 14. Maximiscin Induces DNA Damage, Activates DNA Damage Response Pathways, and Has Selective Cytotoxic Activity against a Subtype of Triple-Negative Breast Cancer. (nih.gov)
  • The genetic backgrounds of these cells were characterized for the status of key pathways and gene products involved in drug response and cell death. (nih.gov)
  • DNA damage that cannot be repaired within a few hours), then DNA damage response pathways trigger apoptosis. (nih.gov)
  • Breast cancer is one of the most common cancer types and malfunctioning proteins in apoptotic pathways are known to be the main contributors of cancer development. (ijpsonline.com)
  • Although 1 affects different signaling pathways in different cell lines and has multiple functions, we have identified its target proteins, which explain and clarify the universal mechanism of its medicinal efficacy. (nature.com)
  • The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
  • These responses are elicited through signalling pathways, which activate cell cycle checkpoints and basically lead to three cellular fates: cycle arrest promoting DNA repair, senescence (permanent arrest) or cell death. (biomedcentral.com)
  • Here, we advance a qualitative model covering DNA damage response pathways, focusing on G1/S checkpoint enforcement, supposedly more sensitive to arrest than G2/M checkpoint. (biomedcentral.com)
  • We define a discrete, logical model encompassing ATM (ataxia telangiectasia mutated) and ATR (ATM and Rad3-related) pathways activation upon DNA damage, as well as G1/S checkpoint main components. (biomedcentral.com)
  • As a step towards an integrative model of DNA-damage response pathways to better cover the onset of senescence, our model focuses on G1/S checkpoint enforcement. (biomedcentral.com)
  • Deguelin induced cell apoptosis by blocking anti-apoptotic pathways, such as PI3K-Akt, IKK-IκBα-NF-κB and AMPK-mTOR-survivin, while inhibiting tumor cell propagation and malignant transformation through p27-cyclinE-pRb-E2F1 cell cycle control and HIF-1α-VEGF anti-angiogenic pathways. (spandidos-publications.com)
  • Deguelin has been reported to kill cancer cells or inhibit tumor growth through targeting apoptosis, cell cycle arrest and anti-angiogenesis, including PI3K-Akt, IKK-IκBα-NF-κB and AMPK-mTOR-survivin pathways. (spandidos-publications.com)
  • Therefore, key regulatory components involved in apoptotic or anti-apoptotic pathways are necessary with a view to developing new targeting agents, with fewer side effects, eliminating cancer cells ( 9 ). (spandidos-publications.com)
  • lncRNAs can reprogram cancer lipid metabolism pathways and are important factors regulating abnormal lipid metabolism in cancer ( 6 ). (spandidos-publications.com)
  • In cancer cells, DDR pathways are often upregulated due to genomic instability, elevating the chances of resistance to DNA-damaging therapies. (vietnamtribune.com)
  • Rather than depending on in vitro and in vivo screens for antiproliferative activity, investigators can now focus on new molecular targets and pathways essential for the development and maintenance of the cancer phenotype. (nih.gov)
  • Drug induced double-strand breaks also trigger a DNA damage response characterized by activation of serine-threonine kinases driving the ATMCHK2 and ATR-CHK1 ANGPTL3 Inhibitors MedChemExpress mediated checkpoint pathways and cell cycle arrest at the G1/S and G2/M cell cycle phase transitions. (achrinhibitor.com)
  • This guide highlights some of the key pathways that are commonly dysregulated in cancer. (technologynetworks.com)
  • Finally, downstream nuclear targets of signaling pathways like the transcription factors Myc and NF-κB, chromatin remodelers, and cell cycle effectors are also commonly altered. (technologynetworks.com)
  • Decoding these cellular changes and correlating to molecular pathways are key to novel discoveries that will help develop the next generation of cancer treatments. (technologynetworks.com)
  • Benjamin D. Cancer Signaling Pathways and Crosstalk. (technologynetworks.com)
  • In this study, we tested the effects of Valproic Acid on the signaling pathways involved in breast cancer cells viability, apoptosis and in Reactive Oxygen Species (ROS) production using ER-α positive MCF-7 and triple negative MDA-MB-231 cells. (biomedcentral.com)
  • As a result, cytoskeleton and cell-cell adhesion pathways, calcium-channels and glutamate receptors, as well as oxidoreductase and endoplasmic reticulum-associated degradation pathways were found to be the most important and redundant findings associated to meningioma progression. (neurorgs.net)
  • ATR is a potential target for anticancer therapeutics to induce cancer cell death by inhibiting cell cycle arrest pathways in response to chemotherapeutics. (nih.gov)
  • Another study reported that total saponins of A. membranaceus (AST) possess potential antitumorigenic effects in human colon cancer cells and tumor xenografts through modulation of both mTOR and ERK signaling pathways [ 9 ]. (biomedcentral.com)
  • The pathogenesis of laryngeal cancer is not clearly understood, but it is undoubtedly a complex developmental process involving multiple pathways and genes. (ijpsonline.com)
  • p38 mitogenactivated protein kinase/prostaglandin-endoperoxide synthase 2-related targets and signalling pathways have repeatedly been shown to play an important role in the development of tumours, including laryngeal cancer. (ijpsonline.com)
  • This paper explores the potential association of p38 mitogen-activated protein kinase/prostaglandin-endoperoxide synthase 2 related targets and pathways with the development of laryngeal cancer in the context of the mechanisms of action of these pathways in a variety of tumors, with the aim of predicting possible targets for drug treatment of laryngeal cancer. (ijpsonline.com)
  • The study of p38 Mitogen-Activated Protein Kinase (p38 MAPK)/Prostaglandin- Endoperoxide Synthase 2 (PTGS2) related targets and signaling pathways can help to elucidate and refine the biological characteristics of laryngeal cancer, and provide guidance for the diagnosis and treatment of laryngeal cancer and the development of laryngeal cancer drugs. (ijpsonline.com)
  • Figure 1 below schematically illustrates a summary of the TOR signaling pathways in mammalian cells under nutrient replete and restricted conditions, and under rapamycin treatment. (nih.gov)
  • Specifically, it regulates the organization of apical plasma membrane in epithelial cells, disk morphogenesis during early retinal development, MAPK and Akt signaling pathways, and in cholesterol metabolism. (nih.gov)
  • This study was designed to identify the cell cycle phase at which U937 cells are most sensitive to arsenite-induced growth inhibition. (nih.gov)
  • Future study of cell cycle inhibition by arsenic should consider that the effect may not be mediated by the major cell cycle checkpoints. (nih.gov)
  • 9 Extension of these preliminary findings suggested that the association of competent protein forms of each member of the p53-p33 ING1b complex is essential for the optimum inhibition of cell growth and transactivation by TP53. (bmj.com)
  • a G0/G1 cell cycle arrest, an inhibition of BrdU incorporation and a reduced level of cyclin D1. (vittori-lab.com)
  • 1 Inhibition of CDK4 and CDK5 leads to a reversible pause in the cell cycle in the G1 phase for approximately 16 hours. (drugbank.com)
  • HDAC3 is very important for maintaining genomic stability25 and DNA damage handle,26 and its inhibition has been shown to induce DNA harm.27 Consequently, below the exact same conditions as described above, DNA harm was assessed in the ITC-treated colon cancer cells applying the comet assay. (caspaseinhibitor.com)
  • These events were more prominent in cells stimulated with IL-21 compared with CD40L alone, indicating that, following NAE inhibition, the culture conditions were able to direct CLL cell fate from an NF-κB inhibition to a Cdt1 induction program. (elsevierpure.com)
  • We hypothesized that Chk1/2 inhibition (CHKi) with prexasertib may enhance cytotoxicity from EGFR inhibition plus radiotherapy in head and neck squamous cell carcinoma (HNSCC). (aacrjournals.org)
  • The inhibition of mitochondrial activity by various pharmacological inhibitors, as well as by gene-specific targeting using siRNA-mediated technology showed a dramatic attenuation of polyploidy and bi-nucleation development during in vitro stromal cell decidualization, suggesting mitochondria play a major role in positive regulation of decidual cell polyploidization. (plos.org)
  • Current research in carcinogenesis has identified many enzymes, genetic lesions, and their cellular constituents associated with inhibition and progression of pre-cancers to invasive disease. (nih.gov)
  • Here, we explored the role of PLK1 inside the sensitivity of cell lines of distinct tumor forms to SN38 and evaluated pharmacological inhibition of PLK1 in preclinical models as an approach to improve CPT11 antitumor activity and overcome drug resistance.of treatment with SN38, the active metabolite of CPT11, in squamous cell carcinoma (SCC) cell lines previously characterized for sensitivity towards the CPTs [24, 25]. (achrinhibitor.com)
  • The inhibition effect of APS on the P65 mRNA and protein was detected by reverse transcriptase-PCR (RT-PCR) and Western blot in A549 cells respectively. (biomedcentral.com)
  • The inhibition effect of APS on the p50, CyclinD1 and Bcl-xL protein was detected by Western blot in A549 cells respectively. (biomedcentral.com)
  • PMA can partially alleviate the inhibition activity of P65 transcription activity of APS in A549 cells, and Bay can enhance the down-regulation of the P65 transcription activity induced by APS in A549 cells. (biomedcentral.com)
  • Basic research indicates that Astragalus saponins could induce growth inhibition and apoptosis in human colon cancer cells and tumor xenografts [ 8 ]. (biomedcentral.com)
  • 18. GPER mediates enhanced cell viability and motility via non-genomic signaling induced by 17β-estradiol in triple-negative breast cancer cells. (nih.gov)
  • Cellular responses to docetaxel were assessed by characterizing cell viability, cell cycle checkpoint arrest, and mechanisms of cell death. (nih.gov)
  • Cell viability percentages, cell cycle phases, which cells were on, apoptotic cell rates, drug efflux levels via P-gp, expression levels of Mdr-1 as well as certain genes in p53 apoptotic pathway were measured. (ijpsonline.com)
  • ITCs decreased the viability of HCT116 cells (Fig. 3A), with SFN, 6-SFN and 9-SFN getting highly significant (p 0.001). (caspaseinhibitor.com)
  • alkyl chain length increases ITc-induced loss of viability, cell cycle arrest and apoptosis. (caspaseinhibitor.com)
  • hcT116 cells treated for 24 h with 15 M ITc, as in Figure 1, had been examined for (A) cell viability by ccK-8 assay, (B) DNa content by means of flow cytometry or (C) caspase activity and paRp cleavage. (caspaseinhibitor.com)
  • Changes in cell viability, apoptosis, lactate dehydrogenase release, and cell cycle analysis were measured by cell counting kit-8 assay, annexin V/ propidium iodide staining, and enzyme-linked immunosorbent assay, respectively. (medsci.org)
  • The molecules which facilitated this repair were photoactivated by wavelengths of light only seen in the visible spectrum, explaining why instead of lethality, survival and retained viability was seen in these treated cell cultures. (clinuvel.com)
  • In different types of cancer, a variety of epigenetic mechanisms can be perturbed, such as the silencing of tumor suppressor genes and activation of oncogenes by altered CpG island methylation patterns, histone modifications, and dysregulation of DNA binding proteins. (wikipedia.org)
  • It has been proved that multiple types of cancer including breast cancer are developed due to malfunctioning of the genes, which code antiapoptotic proteins, apoptosis inhibitors or tumor suppressors [ 6 , 7 ]. (ijpsonline.com)
  • In this part of interphase, the cell synthesizes mRNA and proteins in preparation for subsequent steps leading to mitosis. (wikipedia.org)
  • Once the required proteins and growth are complete, the cell enters the next phase of the cell cycle, S phase. (wikipedia.org)
  • More recent work has revealed that MMR proteins play an important role in cell cycle arrest and apoptosis in response to certain DNA damaging agents. (uchc.edu)
  • First, we are examining the cellular functions of the MMR proteins and the effects of cancer-causing missense mutations by studying how these mutant proteins perform in DNA repair, cell cycle checkpoint signaling, apoptosis signaling and other functional assays. (uchc.edu)
  • tumor_purity tumor purity C C177536 GDC Property Terminology C13202 Chromosome A structure found in cells that is comprised of a strand of linearized double-stranded DNA plus proteins that package the DNA in a condensed coil form and regulate chromosomal function. (nih.gov)
  • Genetic alterations to cellular genes may be inherited or arise spontaneously because of DNA damage from an environmental carcinogen or mutation from replication errors.1 Many common genetic lesions in cancer involve signaling proteins. (technologynetworks.com)
  • Apoptosis and cellular senescence-related proteins were measured by Western blotting. (medsci.org)
  • These changes were markedly reversed by EPA administration, and the expressions of apoptosis and cellular senescence-related proteins were reversed by EPA treatment. (medsci.org)
  • Neoantigens are new proteins that form on cancer cells when certain mutations occur in tumor DNA. (nih.gov)
  • DHA provides little influence on the formation of cholesterol in SW620 cells [23] though it escalates the sterol regulatory component binding proteins-2 (SREBP-2) which induces the transcription of many genes mixed up in cholesterol synthesis - e.g. (biospraysehatalami.com)
  • With proteins required for almost all tasks of cellular life, preserving the integrity of our genes, and therefore DNA, is thus critical to upholding normal cell activity and survival. (clinuvel.com)
  • It cleaves the membrane-bound precursor of TUMOR NECROSIS FACTOR-ALPHA between ALANINE 76 and VALINE 77 to its functional form, as well as several other CELL SURFACE PROTEINS to their soluble forms, including AMYLOID BETA-PROTEIN PRECURSOR and PRION PROTEIN. (nih.gov)
  • HN - 2017 MH - ADAM12 Protein UI - D000072199 MN - D8.811.277.656.675.374.102.125 MN - D9.400.430.500.125 MN - D12.776.395.33.125 MS - A disintegrin and metalloproteinase domain-containing protein that is expressed as two alternatively-spliced forms: a long transmembrane form (ADAM12-L) and a short soluble form (ADAM12-S). It modulates the cleavage of INSULIN-LIKE GROWTH FACTOR BINDING PROTEINS and may also regulate CELL FUSION during MYOGENESIS. (nih.gov)
  • In contrast to ADAM proteins, which reside on CELL MEMBRANES, ADAMTS proteases are secreted and function in the EXTRACELLULAR MATRIX. (nih.gov)
  • This study describes a nonapoptotic response to docetaxel therapy in human breast cancer cells of increasing cancer progression (MCF-10A, MCF-7, and MDA-mb-231). (nih.gov)
  • Arsenite delays progression through each cell cycle phase and induces apoptosis following G2/M arrest in U937 myeloid leukemia cells. (nih.gov)
  • Arsenic has previously been shown to inhibit cancer cell cycle progression, but the targeted cell cycle phase has been debated. (nih.gov)
  • These fractions were monitored for cell cycle phase progression in the presence and absence of sodium arsenite. (nih.gov)
  • We found an overall reduction in cell cycle progression rather than induction of arrest at one specific checkpoint. (nih.gov)
  • Despite research progress, the lack of appropriate cell lines and large-scale clinical validation methods greatly hinders the exploration of biomarkers associated with the PSCC progression. (researchsquare.com)
  • Some authors will say that the restriction point and the G1/S checkpoint are one and the same, but more recent studies have argued that there are two different points in the G1 phase that check the progression of the cell. (wikipedia.org)
  • The G1/S checkpoint is the point between G1 phase and the S phase in which the cell is cleared for progression into the S phase. (wikipedia.org)
  • Cellular uptake of ruthenium complexes was determined by ICP-MS. Cell cycle progression and apoptosis were assessed using propidium iodide and Annexin V flow cytometry. (biomedcentral.com)
  • Ruthenium treatment upregulated the marker genes involved in apoptosis and cell cycle progression while it downregulated BRCA1 mRNA and replication of HCC1937 cells. (biomedcentral.com)
  • However, TNBC has a less favorable clinical outcome in terms of the nature and progression, compared with other subtypes of breast cancer. (biomedcentral.com)
  • also comprises p53 together with cell cycle regulation allowing to investigate the impact of DNA damage intensities on cell cycle progression [ 14 ]. (biomedcentral.com)
  • Subsequently, studies on tumor-induced immune suppressive mechanisms have identified multiple suppressor cell populations and inhibitory molecules, all of which exert critical regulatory roles in tumor generation and progression ( 6 - 8 ). (frontiersin.org)
  • The FDA subsequently expanded the approved use of nivolumab to patients with advanced squamous non-small cell lung cancer (NSCLC) with progression on or after platinum-based chemotherapy in 2015 ( 12 ). (frontiersin.org)
  • The zinc finger protein 57 (ZFP57) plays crucial functions during the progression of cancer and is reported as a prognostic and therapeutic candidate in a variety of cancer. (jcancer.org)
  • Additionally, ZFP57 transcriptionally regulated BRCA1 expression in OC, indicating that ZFP57 may affect BRCA1 mediated G1 checkpoint to regulate the cell cycle of OC cells and further influence the progression of OC. (jcancer.org)
  • The main pathway by which cancer cell lipid metabolism influences cancer progression is increased fatty acid synthesis. (spandidos-publications.com)
  • lncRNAs are widely known for their key role in human cancer progression ( 11 ). (spandidos-publications.com)
  • A promising target is cyclin-dependent kinase 5 (CDK5), the hyperactivity of which has been shown to have a role in cancer progression. (nih.gov)
  • RAB20, a member of the RAS GTPase oncogene family, promotes tumorigenesis in several cancers with poor survival outcomes but its role in penile squamous cell carcinoma (PSCC) remains unclear. (researchsquare.com)
  • This study was undertaken to examine the possible cytotoxic effect of three novel complexes (0.125-64 µ g/mL) on human gastric carcinoma (AGS), esophageal squamous cell carcinoma (Kyse-30), and hepatocellular carcinoma (HepG2) cell lines. (hindawi.com)
  • Cutaneous squamous cell carcinoma (SCC) is one of the most frequent malignancies in humans and academia as well as public authorities expect a further increase of its incidence in the next years. (frontiersin.org)
  • Head and neck tumors are the sixth most common malignant tumors in the world, in which Squamous Cell Carcinoma (SCC)[ 1 ] predominantly, accounting for approximately 90 % of cases. (ijpsonline.com)
  • Therefore, p33 ING1b expression could be used as a marker of differentiation in invasive breast cancer. (bmj.com)
  • These results support the view that loss of p33 ING1b may be an important molecular event in the differentiation and pathogenesis of invasive breast cancer. (bmj.com)
  • Cell Death and Differentiation. (wustl.edu)
  • The disturbance of epigenetic processes in cancers, can lead to a loss of expression of genes that occurs about 10 times more frequently by transcription silencing (caused by epigenetic promoter hypermethylation of CpG islands) than by mutations. (wikipedia.org)
  • Indeed, cancer cells can become addicted to the transcriptional silencing, due to promoter hypermethylation, of some key tumor suppressor genes, a process known as epigenetic addiction. (wikipedia.org)
  • Cell cycle exit depends upon turning off these genes. (nih.gov)
  • We have identified 42 genes that restrict genome duplication to once per cell division by preventing either DNA re-replication or unscheduled endoreplication. (nih.gov)
  • All 42 genes participate in one or more of eight cell cycle events. (nih.gov)
  • Therefore, expression levels of p53 and other genes in p53 pathway have major role on cancer development [ 11 ]. (ijpsonline.com)
  • P53 is a sequence-specific transcriptional activator of genes involved in cellular outcomes such as cell cycle arrest and apoptosis. (nih.gov)
  • Another project stems from our earlier finding that in some cells p53 is impaired in its ability to induce transcription from some of its target genes when cells are blocked in S phase. (nih.gov)
  • The most common hereditary disease that predisposes patients to colorectal cancer is Lynch syndrome (LS) which stems from mutations in the mismatch repair (MMR) genes. (uchc.edu)
  • The research in my laboratory involves an array of techniques from cell biology to molecular genetics to genomics to address the fundamental question of why mutations in DNA mismatch repair genes cause cancer. (uchc.edu)
  • We are predominantly interested in using cancer-associated missense mutations of the MSH2 and MSH6 genes to understand the functions of mismatch repair affected during colorectal tumorigenesis. (uchc.edu)
  • Based on functional enrichment analyses, up-regulated polyploidy genes appeared to implicate several functions, which primarily include cell/nuclear division, ATP binding, metabolic process, and mitochondrial activity, whereas that of down-regulated genes primarily included apoptosis and immune processes. (plos.org)
  • Ontology analysis of the transcription hub genes identified microtubule-associated cell-cycle processes as key drivers of such network. (neurorgs.net)
  • 5. Lippia origanoides extract induces cell cycle arrest and apoptosis and suppresses NF-κB signaling in triple-negative breast cancer cells. (nih.gov)
  • Other studies have shown inhibitors of CDK4 and CDK6 enhance T-cell activation, upregulating major histocompatibility complex (MHC) class I and II, and stabilize programmed death-ligand 1 (PD-L1). (drugbank.com)
  • Treatment of the CD40-stimulated CLL cells with MLN4924 resulted in deregulation of Cdt1, a DNA replication licensing factor, and cell cycle inhibitors p21 and p27. (elsevierpure.com)
  • Treatment with HDAC KLF4 antibody inhibitors reversed the altered transcriptional events and reestablished the sensitivity of the ER to tamoxifen resulting in substantial Brevianamide F Bcl-2 downregulation, growth arrest and apoptosis. (acp2018.org)
  • As such, HDAC inhibitors have become Brevianamide F an attractive constituent of combination regimens, including hormone therapy for the treatment of breast cancer [1]. (acp2018.org)
  • Recent clinical success with immune checkpoint inhibitors, chimeric antigen receptor T-cell therapy, and adoptive immune cellular therapies has generated excitement and new hopes for patients and investigators. (frontiersin.org)
  • It is therefore currently quite unclear as to what extent and under which particular circumstances sirtuin activators and/or inhibitors will find their place in the treatment of age-related disease and cancer. (biomedcentral.com)
  • DNA protein cross linked cells were washed twice with cold PBS, and were handled with lysis buffer supplemented selleck chemicals TGF-beta inhibitors with twenty mM sodium butylate for five min on ice. (fak-signal.com)
  • Numerous HDAC inhibitors have been studied and several of them have shown to influence growth, apoptosis and invasiveness in cancer cells both in vitro and in vivo . (biomedcentral.com)
  • p33 ING1b , p53, oestrogen receptor (ER), and progesterone receptor (PgR) expression was studied in 86 primary invasive breast cancers using immunohistochemistry. (bmj.com)
  • Breast cancers with a BRCA1 mutation are also frequently triple-negative. (biomedcentral.com)
  • Our results could provide an alternative approach to finding effective therapeutic ruthenium-based agents with promising anticancer activity, and demonstrated that the BRCA1 RING domain protein was a promising therapeutic target for breast cancers. (biomedcentral.com)
  • Triple-negative breast cancers (TNBCs) are defined by the lack of expression of an estrogen receptor (ER), a progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2). (biomedcentral.com)
  • They represent approximately 15% of all breast cancers and account for a higher percentage of breast cancer related mortality detected in African and African-American women [ 1 ]. (biomedcentral.com)
  • Introduction About 70% of all breast cancers express the estrogen receptor (ER). (acp2018.org)
  • We utilize public data as and molecular data generated within the SCANB project, a continuous collection of consecutive material of breast cancers operated in Southern Sweden. (lu.se)
  • Since p53 was identified as a tumor suppressor protein in late 1980's, various studies have focused on its contributions on cell cycle arrest, senescence, apoptosis and autophagy [ 8 , 9 ]. (ijpsonline.com)
  • The inhibitor of growth gene 1 (ING1) is a modulator of cell cycle checkpoints, apoptosis, and cellular senescence. (bmj.com)
  • 2, 3 Since then, ING1 has been established as a modulator of cell cycle checkpoints, apoptosis, cellular senescence, and the maintenance of genomic stability. (bmj.com)
  • The mechanisms responsible for this decay are both cell intrinsic, such as cellular senescence, as well as cell-extrinsic, such as changes in the regenerative environment. (mdpi.com)
  • In particular, how cells are induced to senescence upon DNA damage attracted a lot of attention, this phenotype being associated to tumour suppression [ 9 ]. (biomedcentral.com)
  • Among other components, the tumour suppressor p53 protein triggers cellular programs that lead to different fates: transient arrest followed by cell cycle re-entry upon damage repair, permanent cell cycle arrest (senescence) or, if the damage is irreparable, initiation of cell death program (apoptosis). (biomedcentral.com)
  • Purvis and co-workers proposed a model based on delayed differential equations to further study how p53 dynamics influences the decision between apoptosis and senescence [ 15 ]. (biomedcentral.com)
  • We aimed to examine whether EPA could protect vascular endothelial cells under stress conditions against stress-induced accelerated senescence (SIAS). (medsci.org)
  • Cultured HUVECs under oxidative and glucolipotoxic stresses revealed accelerated senescence and increased apoptosis. (medsci.org)
  • Cellular senescence is a process in which various stressors permanently stop cell division, resulting in cell changes that appear as senescent-associated secretory phenotype (SASP) ( 2 ). (medsci.org)
  • points out, in a colorectal cancer there are usually about 3 to 6 driver mutations and 33 to 66 hitchhiker or passenger mutations. (wikipedia.org)
  • Loss of imprinting of insulin-like growth factor gene (IGF2) increases risk of colorectal cancer and is associated with Beckwith-Wiedemann syndrome which significantly increases the risk of cancer for newborns. (wikipedia.org)
  • The change in lipid metabolism has been confirmed to have a role in several tumor types, such as esophageal, gastric, colorectal and liver cancer. (spandidos-publications.com)
  • Cancer and Metastasis Reviews. (wustl.edu)
  • In the comprehensive signaling network of tumorigenesis, metastasis, apoptosis and angiogenesis, deguelin is pivotal in inducing apoptotic cell death and prohibiting their malignant transformation. (spandidos-publications.com)
  • Among the priorities of the 2001 and 2002 Bypass Budgets is a plan to identify and use molecular targets for the discovery and clinical testing of new anticancer agents based on the molecular mechanisms that underlie neoplastic transformations, cancer growth and metastasis. (nih.gov)
  • Regardless of cell type, the tumorigenic changes that drive cancer growth and metastasis are complex. (technologynetworks.com)
  • Cancer is a complex entity and regardless of cancer type, there are frequently observed cellular changes involved in tumorigenesis, tumor growth, and metastasis. (technologynetworks.com)
  • NF-κB plays important roles in genesis, growth, development and metastasis of cancer. (biomedcentral.com)
  • Laryngeal cancer is a malignant tumor of the head and neck with clinical features of high recurrence and metastasis and a poor prognosis. (ijpsonline.com)
  • How is Cancer related to DNA replication? (nih.gov)
  • Normal cells have multiple checkpoints that respond to stress by preventing further initiation events during S-phase, stabilizing replication forks until they are repaired, and preventing the onset of mitosis until DNA replication is completed. (nih.gov)
  • Thus DOX inhibits replication and transcription causing cell cycle arrest and apoptosis afterwards [ 16 ]. (ijpsonline.com)
  • It was of interest that BRCA1 mRNA and replication of BRCA1-defective cells were downregulated. (biomedcentral.com)
  • We have extended these findings by showing that while p53 can bind to its sites within these promoters and recruit histone acetylases, TFIID and RNA polymerase, transcription elongation by RNA polymerase is significantly reduced when the DNA replication checkpoint is activated. (nih.gov)
  • The biological activity of cisplatin cytotoxicity involves the binding of the drug to DNA and non-DNA targets and inhibits transcription and DNA replication that finally leads to apoptosis, necrosis, or both of them. (hindawi.com)
  • Nevertheless, we discovered that amounts of the duplication aspect Cdc6 reduced and pre-replication processes had been vulnerable in methionine-stressed MDAMB468 but not really resistant cells. (cancer-pictures.org)
  • Treatment with Debio 0123 to inhibit WEE1 has the advantage of selectively impacting tumor cells, which, due to the increasing replication stress during the S-phase, become more reliant on the proper functioning of the G2-M checkpoint. (vietnamtribune.com)
  • Improved phosphorylation of ATR was observed at about 6 h post-treatment with SFN, 6-SFN and 9-SFN, followed by H2AX phosphorylation at six?two h then checkpoint kinase (Chk2) phosphorylation at 12?4 h. (caspaseinhibitor.com)
  • Upon oral administration, polo-like kinase 4 inhibitor CFI-400945 selectively inhibits PLK4, which results in the disruption of mitosis and the induction of apoptosis. (nih.gov)
  • therapeutic_agents C1909 therapeutic_agents C C177537 GDC Value Terminology C115970 Ibcasertib An orally available, small molecule inhibitor of select serine-threonine kinases, including aurora kinase B (aurora B), vascular endothelial growth factor receptors (VEGFRs), stem cell factor receptor (c-KIT), and platelet-derived growth factor receptors (PDGFRs), with potential antineoplastic activity. (nih.gov)
  • HER2, a tyrosine kinase receptor, is overexpressed by many cancer cell types. (nih.gov)
  • Identification of a novel protein kinase Cδ-Smac complex that dissociates during paclitaxel-induced cell death. (lu.se)
  • Post-transcriptional control of SIRT1: upon oxidative stress, SIRT1 mRNA is degraded due to a checkpoint-kinase-2-mediated dissociation of the RNA binding protein HuR. (biomedcentral.com)
  • Polo-like kinase 1 (PLK1) Amylmetacresol In Vivo belongs to a household of serine/threonine kinases (PLK1-4) involved in cell cycle regulation [7, 8, 9]. (achrinhibitor.com)
  • Its inactivation mediated by the ATM/ATR signaling is required for induction in the G2/M checkpoint, whereas its kinase activity is necessary for checkpoint termination and cell cycle reentry following DNA damage arrest [8, 10-12]. (achrinhibitor.com)
  • Ataxia telangiectasia mutated and Rad3 Related (ATR) protein kinase is essential for regulating DNA damage checkpoints during the cell cycle. (nih.gov)
  • 10. Lipid nanocarriers of a lipid-conjugated estrogenic derivative inhibit tumor growth and enhance cisplatin activity against triple-negative breast cancer: pharmacokinetic and efficacy evaluation. (nih.gov)
  • Ovarian cancer (OC) which is one of the frequently-occurring gynecologic malignant tumors, endangers the health of women. (jcancer.org)
  • Gene copy number alterations were found for AKT2 and PTEN, which is consistent nationalism with our recent studies showing frequent genetic abnormalities of the PI3K/AKT pathway in primary ovarian cancer.We observed that 1 patient of 9 with PTEN loss was alive, while 10 patients were alive among 18 patients with the stable PTEN and gain in PTEN within 24 months since the enrollment in the study. (ainhibitor.com)
  • Inside a prior study, we observed that an early and considerable apoptosis induction by the CPT ST1968 was linked having a marked reduction of PLK1 levels in human squamous and ovarian cancer cell lines [23]. (achrinhibitor.com)
  • They may be just as important, if not even more important, than genetic mutations in a cell's transformation to cancer. (wikipedia.org)
  • Cancer originates from genetic mutations that are either inherited or result from environmental factors. (nih.gov)
  • Cancer cells lack several of these checkpoints, which means that mutations are more easily generated and restrictions on genome duplication more easily ignored. (nih.gov)
  • Faulty MMR results in an elevated mutation rate (mutator phenotype), which has been proposed to lead to an accumulation of oncogene and tumor suppressor mutations that ultimately cause cancer. (uchc.edu)
  • Most recently, we have begun to characterize the function of the MMR pathway in human pluripotent stem cells and are using CRISPR/Cas9 gene targeting approaches to introduce missense mutations into the endogenous MMR gene loci. (uchc.edu)
  • Put simply, DNA mutations the primary cause of all skin cancers. (clinuvel.com)
  • and acquired resistance to the anti-HER2 monoclonal antibody trastuzumab have also been identified.4 Besides, no targeted therapy is available for aggressive triple-negative breast cancer which is characterized by (-)-Epicatechin the absence of expression of estrogen, progesterone, and HER2 receptors.5 These limitations in breast cancer therapy are strong arguments for the search for optimized therapeutic strategies and the development of new therapeutic agents. (vittori-lab.com)
  • For example, the general cancers cell feature of cardiovascular glycolysis 11-hydroxy-sugiol IC50 almost, known as the Warburg impact, enables malignancy cells to avert thrive and apoptosis in locations of intratumoral hypoxic strain.1 Importantly, the same peculiarities of tumor cell fat burning capacity that promote development and survival also distinguish them from regular cells and therefore represent a potentially suitable for farming field for therapeutic advancement. (cancer-pictures.org)
  • These findings suggest deguelin to be a novel anti-tumorigenic agent for cancer therapeutic intervention. (spandidos-publications.com)
  • They may serve as diagnostic or prognostic biomarkers and therapeutic targets for cancer ( 3 ). (spandidos-publications.com)
  • therapeutic_agents C1909 therapeutic_agents C C177537 GDC Value Terminology C121217 Cifurtilimab A proprietary, non-fucosylated monoclonal antibody directed against the cell surface receptor CD40 with potential immunostimulatory and antineoplastic activities. (nih.gov)
  • Indeed, combining DNA damaging drugs with modulators of cell cycle checkpoints is an emerging method pursued to enhance therapeutic index and clinical efficacy [6]. (achrinhibitor.com)
  • Here, we demonstrate the involvement of EHMT1, a histone lysine methyltransferase, in lung cancer. (nih.gov)
  • Researchers identified that an abundance of fungi in the gut, particularly strains of Candida albicans yeast, could trigger an increase in immune cells, which could worsen lung damage. (medicaldaily.com)
  • Docetaxel is a microtubule-stabilizing taxane that is being used in the clinic for the treatment of breast and prostate cancers and small cell carcinoma of the lung. (nih.gov)
  • Breast cancer is the most common cancer in women, affecting approximately one in nine women in Western countries, and is the second leading cause of female cancer deaths after lung cancer. (bmj.com)
  • Trilaciclib, or G1T28, is a CDK4 and CDK6 inhibitor, indicated to reduce the incidence of chemotherapy induced myelosuppression in patients before topotecan-containing or platinum and etoposide-containing chemotherapy for extensive stage small cell lung cancer. (drugbank.com)
  • Trilaciclib is indicated to reduce the incidence of chemotherapy induced myelosuppression in patients prior to receiving platinum and etoposide-containing or topotecan-containing chemotherapy regimens for extensive-stage small cell lung cancer. (drugbank.com)
  • 1 , 3 When trilaciclib is given to patients with retinoblastoma protein-null small cell lung cancer, it does not interfere with the intended chemotherapy induced cytotoxicity of cancer cells. (drugbank.com)
  • Colon cancer is the third most common malignancy in men and women and ranks behind only lung cancer in cancer deaths. (uchc.edu)
  • Deguelin is known to induce apoptosis by disrupting anti-apoptosis signaling, such as the PI3K/Akt pathway in lung and breast cancer. (spandidos-publications.com)
  • Breast cancer is the second leading cause of death among women after lung cancer. (biomedcentral.com)
  • Here we investigated the antitumor activity of APS in human non-small cell lung cells (A549 and NCI-H358) and the related mechanisms of action. (biomedcentral.com)
  • The dose-effect and time-effect of antitumor of APS were determined in human lung cancer cell line A549 and NCI-H358. (biomedcentral.com)
  • APS has a significant antitumor activity in human lung cancer cells A549 and NCI-H358. (biomedcentral.com)
  • The resulting mechanisms of cell death are likely determined by the mechanism of action of the drug, the dosing regimen used, and the genetic background of the cells within the tumor. (nih.gov)
  • Mechanisms of cell death were determined by Annexin V binding and scoring of cytology-stained cells by morphology and transmission electron microscopy. (nih.gov)
  • RAB20-mediated G2/M phase cell cycle arrest mechanisms were further demonstrated by bioinformatics analysis and Western blotting. (researchsquare.com)
  • We focused on HDAC3 as a FGFR3 Inhibitor manufacturer result of its key role in human colon cancer23,24 and our identification of HDAC3 as an early target for SFN-induced HDAC turnover mechanisms.20 ITCs induce DNA damage in colon cancer cells. (caspaseinhibitor.com)
  • In this review, we discuss the mechanisms of conditioning TME using β-glucan and β-glucan-based nanoparticles, and how this strategy enables future design of optimal combination cancer immunotherapies. (frontiersin.org)
  • In the present review, the progress in understanding the mechanisms of lncRNA action and lipid metabolism in cancer were summarized. (spandidos-publications.com)
  • Here, we summarize the current knowledge about AHR's role in skin carcinogenesis and focus on its impact on defense mechanisms, such as DNA repair, apoptosis and anti-tumor immune responses. (frontiersin.org)
  • The aims of the project are 1) to identify and understand novel mechanisms regulating breast cancer cell death and 2) to identify molecular patterns of importance for the tumor biology and disease outcome. (lu.se)
  • The mechanisms of this effect and what determines whether such a change, rather than cell death, is induced will be analyzed. (lu.se)
  • Glucotoxicity and lipotoxicity are also potential mechanisms for diabetic complications, in addition to beta cell dysfunction. (medsci.org)
  • High-LET radiation has several advantages over low-LET radiation in treating radioresistant human cancers because of its higher relative biological effectiveness (RBE), lower oxygen enhancement ratio (OER), and decreased cell-cycle-dependent radiosensitivity. (oncotarget.com)
  • Atne p53 target promoter, PIG3, Cas/Cse1L has a long range inhibitory effect on tri-methylation of histone H3 lysine 27, a repressive modification, which could explain how Cas/Cse1L and p53 cooperate to regulate some p53 targets and apoptosis. (nih.gov)
  • APS can down-regulate the expression of P65 mRNA and protein of A549 cells and decrease the expression of p50, CyclinD1 and Bcl-xL protein. (biomedcentral.com)
  • PLK4, a member of the polo family of serine/threonine kinases overexpressed in a variety of cancer cell types, plays a crucial role in the regulation of centriole duplication during the cell cycle. (nih.gov)
  • Down Regulation of CLDND1 Induces Apoptosis in Breast Cancer Cells. (lu.se)
  • On the other hand, MG132 treatment stabilized the Scmh1 protein and allowed detection of weak mobility shifted bands on the identical mobility as individuals detected in ubiquitin cotrans fected cells, suggesting that Scmh1 is ubiquitinated and is underneath the regulation of UPS. (fak-signal.com)
  • In MCF-7 treated cells, it has been observed a reduction in mitochondrial membrane potential, a down regulation of the anti-apoptotic marker Bcl-2 and an increase of Bax and Bad, leading to release of cytochrome C and PARP cleavage. (biomedcentral.com)
  • This type of epigenetic mutation allows cells to grow and reproduce uncontrollably, leading to tumorigenesis. (wikipedia.org)
  • Second, we are using pluriopotent stem cells to study the mechanism of the MMR-dependent DNA damage response and how this might impact tumorigenesis. (uchc.edu)
  • It exhibited significant anti-tumorigenesis and anti-proliferative activity in various types of cancer both in vitro and in vivo. (spandidos-publications.com)
  • Cancer refers to tumors and other neoplasia that are malignant and contain cells that can metastasize to distant locations. (nih.gov)
  • In this context, fasting cycles have been shown to retard the growth of tumors and to sensitize various cancer cell types to chemotherapy.6 In regard to the development of alternative or complementary anticancer agents, thiazolidinediones (TZDs) are interesting compounds. (vittori-lab.com)
  • In addition, because cells are less likely to repair radiation injury, charged particle radiation may exert highly lethal effects even on radioresistant tumors, compared to conventional low-LET X-ray or γ-ray irradiation [ 5 - 8 ]. (oncotarget.com)
  • Head and neck squamous cell carcinomas (HNSCC) are aggressive tumors with high recurrence rates and poor 5-year survival. (aacrjournals.org)
  • History analysis concentrated on the elevated glycolysis noticed in tumors frequently, however there are many various other factors of changed cancers cell fat burning capacity having the potential for healing advancement. (cancer-pictures.org)
  • Since dysregulated apoptosis is considered to be necessary for tumor development, apoptosis, a pivotal mechanism for normal homeostasis, is crucial in the therapy of various tumors. (spandidos-publications.com)
  • In spite of extensive efforts and progress in the field of cancer research, the mortality rate due to tumors remains high ( 1 ). (spandidos-publications.com)
  • Dysregulated lipid metabolism is a prominent metabolic alteration in cancer, and increased synthesis or uptake and storage of lipids occur in tumors, promoting rapid cancer cell growth and tumor formation ( 4 , 5 ). (spandidos-publications.com)
  • These tumors are derived from normal arachnoidal cells of the leptomeninges, appear tightly joined to the Dura Mater, and tend to be located along the parasagital sinus, over the cerebral convexity, in the sphenoid wing, around the pontocerebellar angle or along the dorsal region of the spinal cord. (neurorgs.net)
  • Moreover, FACS analysis and cell growth assays showed that knockdown of EHMT1 induced apoptosis and G1 cell cycle arrest via upregulation of CDKN1A in A549 and H1299 cell lines. (nih.gov)
  • Data are representative of at least two independent experiments.manage, TSA, inhibited HDAC activity in cell totally free assays and whole cell lysates (Fig. 1A), without loss of HDAC protein expression (Fig. 1B). (caspaseinhibitor.com)
  • Consequently it was concluded that doxorubicin directly influences apoptotic pathway and multidrug resistance in both MCF-7 and MDA-MB-231 cells even though data all together suggest that the effect is more significant on MDA-MB-231. (ijpsonline.com)
  • Multidrug resistance (MDR) is a term used to define resistance of the cells against multiple drugs, which may or may not be similar in structural or functional basis and is one of the main reasons why attempts of using anticancer agents in cancer therapy fails [ 12 - 14 ]. (ijpsonline.com)
  • Background The experience of P-glycoprotein (Pgp) and multidrug resistance related protein 1 (MRP1) two membrane transporters involved with multidrug resistance of cancer of the colon is improved by high levels of cholesterol in plasma membrane and detergent resistant membranes (DRMs). (biospraysehatalami.com)
  • Triple-negative breast cancer (TNBC) is defined by the absence of expression of estrogen receptor, progesterone receptor and human epidermal growth factor receptor 2. (biomedcentral.com)
  • Microenvironment-mediated upregulation of the B-cell receptor (BCR) and nuclear factor-κB (NF-κB) signaling in CLL cells resident in the lymph node and bone marrow promotes apoptosis evasion and clonal expansion. (elsevierpure.com)
  • Compared to parental MCF7 cells, ER expression in TAMRM was elevated, while progesterone receptor (PGR) was lost. (acp2018.org)
  • 3 Division of Molecular Modification and Cancer Biology, National Cancer Center, Tokyo, Japan. (nih.gov)
  • 6. Growth and molecular interactions of the anti-EGFR antibody cetuximab and the DNA cross-linking agent cisplatin in gefitinib-resistant MDA-MB-468 cells: new prospects in the treatment of triple-negative/basal-like breast cancer. (nih.gov)
  • 12. PLGA-CTAB curcumin nanoparticles: Fabrication, characterization and molecular basis of anticancer activity in triple negative breast cancer cell lines (MDA-MB-231 cells). (nih.gov)
  • 13. Deciphering the molecular mechanism underlying anticancer activity of coumestrol in triple-negative breast cancer cells. (nih.gov)
  • 1 Although numerous molecular abnormalities have been described in breast cancer, the precise pathogenesis of the disease remains unclear. (bmj.com)
  • Currently, there is a lack of effective therapies and known specific molecular targets for this aggressive breast cancer subtype. (biomedcentral.com)
  • Cell-wall β-glucans from natural sources including plant, fungi, and bacteria are molecules that adopt pathogen-associated molecular pattern (PAMP) known to target specific receptors on immune cell subsets. (frontiersin.org)
  • Collectively, analyses of unique polyploidy markers and molecular signaling networks may be useful to further characterize functional aspects of decidual cell polyploidy at the site of implantation. (plos.org)
  • With the development of molecular biology and genomics, lncRNAs have emerged as promising biomarkers for cancer and individual lncRNAs have different characteristics in different cancers ( 12 ). (spandidos-publications.com)
  • Accordingly, the Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute (NCI), and the Chemoprevention Agent Development Research Group, the Division of Cancer Prevention, NCI invite exploratory/developmental grant applications (R21) to exploit molecular targets for drug discovery. (nih.gov)
  • In addition to the present announcement, the NCI announces a related initiative in molecular target drug discovery for cancer treatment and prevention utilizing an additional funding mechanism: Competing Supplements for existing NCI awardees ( https://grants.nih.gov/grants/guide/pa-files/PAR-01-046.html ) which can extend the goals of active grants to include studies related to drug discovery. (nih.gov)
  • Further information on research opportunities regarding molecular targets in drug discovery can be found in the NCI Bypass Budget, The Nation's Investment in Cancer Research: A Budget Proposal for Fiscal Year 2001 at http://2001.cancer.gov and for 2002 at http://plan2002.cancer.gov The purpose of this Program Announcement (PA) is to reorganize the "front end" or gateway to drug discovery. (nih.gov)
  • Investigators are being asked to identify a novel molecular target, or to validate the target as a basis for cancer drug discovery, or to develop an assay for the target. (nih.gov)
  • Applicants may address targets related to the treatment of established cancers, or the prevention of molecular changes which may cause cancer. (nih.gov)
  • Increasing knowledge of human carcinogenesis is providing many new opportunities for study of molecular targets modulated by drugs that might prevent cancer. (nih.gov)
  • With the continuous development of immunology, biochemistry and experimental techniques, it has become a current research trend to investigate the pathogenesis of laryngeal cancer at the molecular level. (ijpsonline.com)
  • Involuntary weight loss affects between 50-80% of those with cancer and is associated with reduced quality of life, psychological implications, increased treatment-related complications and poorer survival [5]. (ucc.ie)
  • METHODS: Incidence for invasive melanoma and 5-year melanoma-specific survival were calculated for whites, blacks, American Indians/Alaskan Natives, Asians/Pacific Islanders (API), and Hispanics using data from 38 population-based cancer registries. (cdc.gov)
  • We recently reported that MLN4924 (pevonedistat), an investigational agent that inhibits the NEDD8-activating enzyme (NAE), abrogates stromal-mediated NF-κB pathway activity and CLL cell survival. (elsevierpure.com)
  • Although the 5 y survival rate for patients with early-stage laryngeal cancer is high, reaching about 80 % to 90 %, patients with mid to late-stage laryngeal cancer have a poor survival prognosis and a high recurrence rate[ 3 - 5 ]. (ijpsonline.com)
  • Overall, patients with laryngeal cancer have a wide range of fluctuating 5 y survival rates[ 6 ] and common complications such as hoarseness and dysphagia[ 7 ], which seriously affect their quality of life. (ijpsonline.com)
  • Without an appropriate response from the affected cells, these lesions are permanently retained within our genome and are mutagenic, threatening overall health and survival. (clinuvel.com)
  • Apoptosis has long been considered to be the prevailing mechanism of cell death in response to chemotherapy. (nih.gov)
  • 1 The temporary cell cycle arrest prevents chemotherapy induced DNA damage in healthy cells, reducing the activity of caspases 3 and 7, which reduces apoptosis of healthy cells. (drugbank.com)
  • In May 2017, the FDA granted approval to pembrolizumab (anti-PD-1 mAb) for locally advanced or metastatic urothelial carcinoma, the most common type of bladder cancer, which progressed during or after platinum-containing chemotherapy or within 12 months of neoadjuvant or adjuvant chemotherapy. (frontiersin.org)
  • They reduced the amount of Pgp and MRP1 contained in DRMs decreased the MED transporters activity restored the antitumor effects of different chemotherapeutic drugs restored a proper tumor-immune system acknowledgement in response to chemotherapy in MDR cells. (biospraysehatalami.com)
  • Surgery, radiation, and chemotherapy are the standard cancer therapies. (biomedcentral.com)
  • The treatment of laryngeal cancer focuses on surgery, including radiotherapy and chemotherapy, etc. (ijpsonline.com)
  • To address this concern, we have explored the cellular responses of BRCA1-defective and triple-negative breast cancer cells, and in vitro BRCA1 interactions induced by the ruthenium(II) complexes containing the bidentate ligand, 5-chloro-2-(phenylazo)pyridine. (biomedcentral.com)
  • Triple-negative MDA-MB-231, BRCA1-defective HCC1937 and BRCA1-competent MCF-7 breast cancer cell lines were treated with ruthenium(II) complexes. (biomedcentral.com)
  • Reduced ING1 mRNA expression has been observed in primary breast cancer expressing wild-type p53. (bmj.com)
  • During G1 phase, the cell grows in size and synthesizes mRNA and protein that are required for DNA synthesis. (wikipedia.org)
  • An increased induction of apoptotic cells as well as an upregulation of p53 mRNA was observed in all tested breast cancer cells. (biomedcentral.com)
  • Upon administration of anvatabart opadotin, the antibody moiety targets and binds to HER2 on tumor cells. (nih.gov)
  • 3, 7 Suppression of p33 ING1b is associated with the loss of cellular growth control and immortalisation, whereas its overexpression arrests cells in the G 0 /G 1 phase of the cell cycle. (bmj.com)
  • Consistently, studies revealed a marked induction of mitochondrial mass and ATP production in polyploid cells. (plos.org)
  • We have made three discoveries that provide proof-of-principle that cancer cells can be induced to undergo apoptosis under conditions where normal cells continue to proliferate. (nih.gov)
  • Importantly, a significant tumor growth delay was observed in vivo in both HPV-positive and HPV-negative cell line xenografts receiving triple combination therapy with CHKi, cetuximab, and radiotherapy without a concomitant increase in toxicity as assessed by mouse body weight. (aacrjournals.org)
  • Mathematical modelling of Trp metabolism in liver cells under hypoxia predicted decreased flux through the KP while metabolic flux through the tryptamine branch significantly increased. (bvsalud.org)
  • The European Society for Clinical Nutrition and Metabolism (ESPEN) guidelines for cancer patients recommend nutrition counselling as the first line of nutrition therapy, and state that the best way to increase energy and protein intake is with normal food: a food-first approach [6]. (ucc.ie)
  • Keywords: methionine-stress, cell routine, Cdc6, homocysteine, S-adenosylmethionine Launch Cancers cell metabolism is altered compared with metabolism of non-transformed cells significantly. (cancer-pictures.org)
  • Cancer cells use lipid metabolism for energy and then rapidly proliferate, invade and migrate. (spandidos-publications.com)
  • ITcs trigger DNa damage and aTR signaling in colon cancer cells. (caspaseinhibitor.com)
  • Conclusions Our work describes a new Azaphen (Pipofezine) biochemical effect of omega 3 PUFAs which can be useful to overcome chemoresistance in MDR colon cancer cells. (biospraysehatalami.com)
  • Medications reducing the endogenous synthesis of cholesterol - e.g. statins and aminobisphosphonates - lower Pgp activity [25] and appearance [26] in HT29-dx colon cancer cells increasing their chemosensitivity to Pgp substrates. (biospraysehatalami.com)
  • 4. The Role and Mechanism of CRT0066101 as an Effective Drug for Treatment of Triple-Negative Breast Cancer. (nih.gov)
  • The primary mechanism of death was determined to be mitotic catastrophe by scoring of micronucleated cells and cells undergoing aberrant mitosis. (nih.gov)
  • The objective of this study was to investigate the effect and the mechanism of low-dose BPA in mammary gland cells. (nih.gov)
  • MLN4924 has been shown to induce DNA damage and cell cycle arrest, but the importance of this mechanism in primary neoplastic B cells has not been studied. (elsevierpure.com)
  • Cisplatin resistance is a mechanism that includes decreased drug accumulation in cancer cells, inactivation by thiol containing biomolecules (glutathione), and enhanced repair of DNA damage [ 21 - 23 ]. (hindawi.com)
  • In the current study, we thus sought to characterize the mechanism underpinning the effectiveness of inhibiting HDAC and ER activity in anti-estrogen-resistant breast cancer. (acp2018.org)
  • This study was aimed to characterize C. nutans standardized fraction (SF1) and to investigate its anticancer mechanism against SiHa cells. (afpm.org.my)
  • EPR was found to be a light dependent recovering mechanism undertaken by these prokaryotic cells to restore the damage to their DNA following UVR exposure. (clinuvel.com)
  • Cancer hallmarks are genomic instability and aneuploidy. (nih.gov)
  • Checkpoint kinases 1 and 2 (Chk1/2) are critical regulators of the DNA-damage response, controlling cell-cycle checkpoints that may permit recovery from therapy-associated genomic stress. (aacrjournals.org)
  • In the present study, to better define the aspects of decidual cell polyploidy, we isolated pure polyploid and non-polyploid decidual cell populations from the in vivo decidual bed. (plos.org)
  • Basal cell carcinoma (BCC) is a nonmelanocytic skin cancer (ie, an epithelial tumor) that arises from basal cells (ie, small, round cells found in the lower layer of the epidermis). (medscape.com)
  • Basal cell carcinoma of the right lower lid. (medscape.com)
  • 17. Knockdown of CAVEOLIN-1 Sensitizes Human Basal-Like Triple-Negative Breast Cancer Cells to Radiation. (nih.gov)
  • Non-melanoma skin cancers, in particular basal cell carcinoma and SCC, are among the most frequent malignancies in humans ( 1 - 3 ). (frontiersin.org)
  • MH - A549 Cells UI - D000072283 MN - A11.251.210.190.80 MN - A11.251.860.180.80 MN - A11.436.54 MS - An immortalized cell line derived from human ADENOCARCINOMA, ALVEOLAR basal epithelial cells isolated from the lungs of a male patient in 1972. (nih.gov)
  • Mechanistic studies indicated that RAB20 depletion arrested the PSCC cell cycle at G2/M via the Chk1/cdc25c/cdc2-cyclinB1 pathway. (researchsquare.com)
  • Treatment demonstrated a higher degree of cytotoxicity than cisplatin against all three cell lines. (biomedcentral.com)
  • SF1 was screened for cytotoxicity activity toward HeLa, SiHa, and normal cells (NIH) cells by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-tetrazolium bromide (MTT) assay. (afpm.org.my)
  • however healthy cells of the bone marrow, hair follicle, epidermis and gastrointestinal tract are extremely sensitive to radiation-induced cell death, limiting the effective use of this therapy for the treatment of cancer. (justia.com)
  • These strategies include eliminating tumor bulk to provoke the release of tumor antigens, using adjuvants to enhance antigen-presenting cell function, and employ agents that enhance immune cell effector activity. (frontiersin.org)
  • Some of these findings were recapitulated in humans and used to develop cancer immunotherapies based on provoking tumor-antigen-specific T-cell responses ( 4 , 5 ). (frontiersin.org)
  • Upon antibody/antigen binding and internalization, opadotin binds to and inhibits tubulin polymerization, which results in G2/M phase arrest and tumor cell apoptosis. (nih.gov)
  • dc.title: Development of patient resources for oncology patients with dysphagia and disease-related malnutrition dc.contributor.author: Hanna, Michelle dc.description.abstract: Cancer is a leading cause of both morbidity and mortality globally [1]. (ucc.ie)
  • Publicamos este trabajo de investigación de Adrián Mosquera Orgueira y José Carlos Iglesias Gómez que se publicó en junio del 2014 en la revista Frontiers in Oncology (propiedad del grupo que edita Nature). (neurorgs.net)
  • Finally, in 3D spheroid culture, compared to control cells, EHMT1 knockdown cells exhibited reduced aggregation of 3D spheroids and clear upregulation of CDKN1A and downregulation of E-cadherin. (nih.gov)
  • This model conveyed tamoxifen resistance through transcriptional upregulation of Bcl-2 and c-Myc, and downregulation of Brevianamide F the cell cycle checkpoint protein p21, manifesting in accelerated growth and reduced cell death. (acp2018.org)
  • The luciferase detection showed that the APS could reduce the P65 transcription activity in A549 cells. (biomedcentral.com)
  • Loss of PLK1 was observed after exposure to SN38 in CaSki cells, sensitive to CPT-induced apoptosis, and not in SiHa cells which are intrinsically resistant to SN38-induced apoptotic cell death as evidenced by Tunel assay performed on each SCC cell lines right after therapy at equitoxic and equimolar concentrations (Suppl. (achrinhibitor.com)
  • New insights into our understanding of cancer cell biology provide a new opportunity for a fundamental re-ordering of approaches to cancer drug discovery. (nih.gov)
  • Through gene ontology analysis of RNA-seq results, we showed that EHMT1 is clearly associated with apoptosis and the cell cycle process. (nih.gov)
  • In normal cells, CpG islands preceding gene promoters are generally unmethylated, and tend to be transcriptionally active, while other individual CpG dinucleotides throughout the genome tend to be methylated. (wikipedia.org)
  • However, in cancer cells, CpG islands preceding tumor suppressor gene promoters are often hypermethylated, while CpG methylation of oncogene promoter regions and parasitic repeat sequences is often decreased. (wikipedia.org)
  • Drug efflux assay results were also shown to be consistent with Mdr-1 gene expression levels in both cell lines. (ijpsonline.com)
  • The inhibitor of growth gene 1 (ING1) was first isolated in early 1996, after it was found to be preferentially expressed in a normal breast cell line but not in a panel of breast cancer cell lines. (bmj.com)
  • Prognostic stromal gene signatures in breast cancer. (lu.se)
  • P53, also known as TP53 or tumor protein is a gene that codes for a protein that regulates the cell cycle and hence functions as a tumor suppression [10] . (madridge.org)