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  • embryonic stem
  • Stem cell researchers at the University of Minnesota have managed to create cancer-killing cells from the human embryonic stem cells in the laboratory in what could be a revolutionary method of treating several types of cancer. (medindia.net)
  • This is the first published research to show the ability to make cells from human embryonic stem cells that are able to treat and fight cancer, especially leukemias and lymphomas," observed Dan Kaufman, assistant professor of medicine in the Stem Cell Institute and Department of Medicine and lead author of the study. (medindia.net)
  • This research suggests it is possible that we could use human embryonic stem cells as a source for immune cells that could better target and destroy cancer cells and potentially treat infections. (medindia.net)
  • In mammals, there are two broad types of stem cells: embryonic stem cells, which are isolated from the inner cell mass of blastocysts, and adult stem cells, which are found in various tissues. (wikipedia.org)
  • Embryonic cell lines and autologous embryonic stem cells generated through somatic cell nuclear transfer or dedifferentiation have also been proposed as promising candidates for future therapies. (wikipedia.org)
  • Stem-cell therapy has become controversial following developments such as the ability of scientists to isolate and culture embryonic stem cells, to create stem cells using somatic cell nuclear transfer and their use of techniques to create induced pluripotent stem cells. (wikipedia.org)
  • Research into human embryonic stem cells is controversial, and regulation varies from country to country, with some countries banning it outright. (wikipedia.org)
  • myocardial
  • Among several clinical trials that have reported that adult stem-cell therapy is safe and effective, powerful effects have been reported from only a few laboratories, infarcts as well as heart failure not arising from myocardial infarction. (wikipedia.org)
  • An example of this is the use of cells to replace cardiomyocytes after myocardial infarction. (wikipedia.org)
  • differentiate
  • The transit amplifying cells divide for a specific number of time before they differentiate into specialized cells. (medindia.net)
  • The cells that differentiate into specialized cells do not divide and do not further assist in the growth of the tumor. (medindia.net)
  • Stem cells are undifferentiated biological cells that can differentiate into specialized cells and can divide (through mitosis) to produce more stem cells. (wikipedia.org)
  • In a developing embryo, stem cells can differentiate into all the specialized cells-ectoderm, endoderm and mesoderm (see induced pluripotent stem cells)-but also maintain the normal turnover of regenerative organs, such as blood, skin, or intestinal tissues. (wikipedia.org)
  • Potency: the capacity to differentiate into specialized cell types. (wikipedia.org)
  • Potency specifies the differentiation potential (the potential to differentiate into different cell types) of the stem cell. (wikipedia.org)
  • Totipotent (a.k.a. omnipotent) stem cells can differentiate into embryonic and extraembryonic cell types. (wikipedia.org)
  • Pluripotent stem cells are the descendants of totipotent cells and can differentiate into nearly all cells, i.e. cells derived from any of the three germ layers. (wikipedia.org)
  • Multipotent stem cells can differentiate into a number of cell types, but only those of a closely related family of cells. (wikipedia.org)
  • Oligopotent stem cells can differentiate into only a few cell types, such as lymphoid or myeloid stem cells. (wikipedia.org)
  • Properties of stem cells can be illustrated in vitro, using methods such as clonogenic assays, in which single cells are assessed for their ability to differentiate and self-renew. (wikipedia.org)
  • citation needed] Possible mechanisms of recovery include: Generation of heart muscle cells Stimulation of growth of new blood vessels to repopulate damaged heart tissue Secretion of growth factors Assistance via some other mechanism It may be possible to have adult bone-marrow cells differentiate into heart muscle cells. (wikipedia.org)
  • In this paradigm multipotent or unipotent cells differentiate into a specific cell type in the lab or after reaching the site of injury (via local or systemic administration). (wikipedia.org)
  • vitro
  • The effect of 89 Zr-oxine labeling on bone marrow cell viability and differentiation was evaluated in vitro . (aacrjournals.org)
  • The researchers found that these natural killer cells generated from the stem cells were able to finish off cancer cells in vitro (in a test tube). (medindia.net)
  • In 1980-82 his group first identified (and provided an in vitro assay for) the human mesenchymal stem cell - the precursor of bone, cartilage, adipose tissue and smooth muscle. (wikipedia.org)
  • G-CSF is a colony stimulating factor which has been shown to have minimal direct in vivo or in vitro effects on the production of other haematopoietic cell types. (wikipedia.org)
  • tumor
  • Tumor cells like stem cells can grow and mature extensively, some of them mature into transit amplifying cells. (medindia.net)
  • The study shows that stem cells are required for the generative capacity of tumor cells. (medindia.net)
  • This result further suggested that breast cancer cells utilize this tissue stem cell molecular program for tumor metastasis, or cancer spread. (medindia.net)
  • The net effect is that this type of drug links T cells (via CD3) and monocytes/macrophages, natural killer cells, dendritic cells or other Fc receptor expressing cells to the tumor cells, leading to their destruction. (wikipedia.org)
  • At an equivalent dose a trifunctional antibody is more potent (more than 1,000-fold) in eliminating tumor cells than conventional antibodies. (wikipedia.org)
  • These drugs evoke the removal of tumor cells by means of (i) antibody-dependent cell-mediated cytoxicity, a process also described for conventional antibodies and more importantly by (ii) polyclonal cytotoxic T cell responses with emphasis on CD8 T cells. (wikipedia.org)
  • i.e. autologous antibodies as well as CD4 and CD8 T cells directed against the tumor were detected. (wikipedia.org)
  • 1954: Farber and his colleagues achieve the first remissions of Wilms' tumor, a common form of childhood cancer, and boost cure rates from 40 percent to 85 percent. (wikipedia.org)
  • In many tumor cells, it causes selective apoptosis, sparing healthy cells. (wikipedia.org)
  • In vivo biodistribution studies demonstrated a "considerably higher" accumulation of Edelfosine in tumor cells than in other analyzed organs. (wikipedia.org)
  • A phase II trial on the effect of Edelfosine on advanced non-small-cell bronchogenic carcinoma had a "remarkable" "high proportion of patients with stationary tumor status" as result, stable disease after initial progression in 50% of the patients. (wikipedia.org)
  • tissue
  • Migration of transferred cells has been studied mainly by tissue biopsies in humans or harvesting organs in animals to determine the presence of donor cells. (aacrjournals.org)
  • A perfect storm of DNA mutation, damage to tissue and stem cell activation lead to cancer. (medindia.net)
  • We changed only one amino acid in normal tissue stem cells, trophoblast stem cells. (medindia.net)
  • The study led by the first authors, research assistant professor Amy N. Abell, and graduate student Nicole Vincent Jordan, showed that similar to triple-negative breast cancer stem cells, normal tissue stem cells also go through the same program of molecular changes during organ development called epithelial mesenchymal transition, or EMT. (medindia.net)
  • The discovery was made using a unique mouse model of tissue stem cell EMT developed in the Johnson laboratory. (medindia.net)
  • The study identified two proteins that regulate the expression of specific genes in tissue stem cells during organ development that control normal EMT. (medindia.net)
  • Adipose tissue (lipid cells), which requires extraction by liposuction. (wikipedia.org)
  • In practice, stem cells are identified by whether they can regenerate tissue. (wikipedia.org)
  • These cells then integrate into the site of injury, replacing damaged tissue, and thus facilitate improved function of the organ or tissue. (wikipedia.org)
  • leukemic cells
  • Study factors that may influence the biodistribution of 131I-BC8 in this patient population, including marrow cellularity, the level of antigen expression by leukemic cells (in relapsed patients), and the degree of antigen saturation by antibody. (clinicaltrials.gov)
  • progenitor
  • Stem cells are progenitor cells that grow and develop into many different types of cells during early stages of life. (medindia.net)
  • Working with Dr. Metcalf in Australia he showed that "colony stimulating factors" were necessary for the growth of normal and leukemic stem cells and progenitor cells. (wikipedia.org)
  • In collaboration with Dr . Shahin Raffi in 1994, a bone marrow-derived endothelial progenitor cell was identified and shown to play an important role in the development of the blood supply of developing tumors. (wikipedia.org)
  • In adult organisms, stem cells and progenitor cells act as a repair system for the body, replenishing adult tissues. (wikipedia.org)
  • In the strictest sense, this requires stem cells to be either totipotent or pluripotent-to be able to give rise to any mature cell type, although multipotent or unipotent progenitor cells are sometimes referred to as stem cells. (wikipedia.org)
  • Unipotent cells can produce only one cell type, their own, but have the property of self-renewal, which distinguishes them from non-stem cells (e.g. progenitor cells, which cannot self-renew). (wikipedia.org)
  • Healthy adult brains contain neural stem cells which divide to maintain general stem-cell numbers, or become progenitor cells. (wikipedia.org)
  • In healthy adult laboratory animals, progenitor cells migrate within the brain and function primarily to maintain neuron populations for olfaction (the sense of smell). (wikipedia.org)
  • versus
  • However, it has been shown that genes responsible for cytokine signaling, inflammatory response, and regulation of cell cycle are differentially expressed in patients with fatal GvHD versus "indolent" GvHD. (wikipedia.org)
  • 1993
  • 1993: Dana-Farber investigators discover the gene that increases the risk for a common type of colon cancer. (wikipedia.org)
  • Lifetime Achie
  • 2011: Lifetime Achievement Award, Cancer Research and Treatment Fund 2013: The C. Chester Stock Award, (Memorial Sloan-Kettering Cancer Center) Dr Moore received his Bachelor of Medicine degree in 1963 and his Doctor of Philosophy degree in 1967 from the University of Oxford. (wikipedia.org)
  • He was awarded the Bristol Myers Squibb Award for Distinguished Achievement in Cancer Research and the American Society for Blood and Marrow Transplantation Lifetime Achievement Award. (wikipedia.org)
  • clinical
  • In collaboration with Amgen, recombinant G-CSF (Neupogen) was developed and in 1987 the first clinical studies were begun at Memorial Sloan-Kettering in cancer patients and pediatric patients with a genetic form of neutropenia. (wikipedia.org)
  • Clinical and animal studies have been conducted into the use of stem cells in cases of spinal cord injury. (wikipedia.org)
  • Catumaxomab, was the first to be approved for clinical use (in 2009 for the treatment of malignant ascites in cancer patients). (wikipedia.org)
  • conventional
  • Although the high-dose treatment did not increase overall survival at 5 years compared with conventional treatment, women on the high-dose treatment survived significantly longer before experiencing recurrence of cancer. (cochrane.org)
  • In addition, its intact Fc-part can bind to an Fc receptor on accessory cells like conventional monospecific antibodies. (wikipedia.org)
  • Disorders
  • Our main goal is to provide the best care for children, adolescents and young adults with cancer, hematological non-malignant disorders and immune deficiencies. (fnkc.ru)
  • Our Center, Dmitry Rogachev National Research Center of Pediatric Hematology, Oncology and Immunology - is one of the largest institutions in the field of cancer, inborn and acquired blood disorders and immune deficiencies. (fnkc.ru)
  • Wolfson Children's Hospital provides hematology (blood disorders) and oncology (cancer) services in partnership with Nemours Children's Specialty Care, Jacksonville and the University of Florida College of Medicine, Jacksonville. (wolfsonchildrens.com)
  • His interests currently include nutrition and dietary therapy, herbal treatments, bio-identical HRT and intravenous nutritional therapy for chronic diseases such as CFS, adrenal fatigue, thyroid disorders, male and female menopause and cancer. (thecancerrevolution.co.uk)
  • Plasma cell dyscrasias (also termed plasma cell disorders and plasma cell proliferative diseases) are a spectrum of progressively more severe monoclonal gammopathies in which a clone or multiple clones of pre-malignant or malignant plasma cells (sometimes in association with lymphoplasmacytoid cells or B lymphocytes) over-produce and secrete into the blood stream a myeloma protein, i.e. an abnormal monoclonal antibody or portion thereof. (wikipedia.org)
  • More recent advances have resulted in the use of HSC transplants in the treatment of cancers and other immune system disorders. (wikipedia.org)
  • PMID
  • Journal of Biological Chemistry, 2007 PMID 17895239 From bytes to bedside: data integration and computational biology for translational cancer research. (wikipedia.org)
  • Journal of Immunology, 2004 PMID 15494497 Nicotine activates nuclear factor of activated T cells c2 (NFATc2) and prevents cell cycle entry in T cells. (wikipedia.org)
  • Journal of the American Society of Blood and Marrow Transplantation, 2004 PMID 15205666 Rapamycin-resistant proliferation of CD8+ T cells correlates with p27kip1 down-regulation and bcl-xL induction, and is prevented by an inhibitor of phosphoinositide 3-kinase activity. (wikipedia.org)
  • Malignancy
  • However, in the past a number of different terms were used for BPDCN due to their uncommon immunophenotypic, histopathological and clinical features, including blastic NK leukemia/lymphoma, histiocytic lymphoma or histiocytic associated hematologic malignancy, cutaneous a granular CD4+ CD56+ hematodermic neoplasm and NK-cell lymphoma or myelo-monocytic precursor - related lymphoma (5-12). (czytelniamedyczna.pl)
  • Experimental chimeras have been used to study a number of biological questions, including the origin and fate of cell lineages during embryonic development, immunological self-tolerance, tumor susceptibility, and the nature of malignancy. (thefreedictionary.com)
  • At the other end of this spectrum, detection of the myeloid protein indicates the presence of a hematological malignancy, i.e. multiple myeloma, Waldenström's macroglobulinemia, or other B cell-associated neoplasm, that derives stepwise from its MGUS precursors. (wikipedia.org)
  • However, the cited gene changes can go awry in plasma cells by, for example, placing a gene that ordinarily controls cell growth adjacent to the normally highly active antibody gene promotor thereby creating a cancer-causing oncogene or, more commonly, by forming extra chromosomes (see trisomy) or chromosomes that have deleted or repetitive sections, any of which such changes may promote malignancy in more complex and less well understood ways. (wikipedia.org)
  • The lack of the normal distribution of these B cells is one basis for demonstrating clonality, the key element for establishing a diagnosis of any B cell malignancy (B cell non-Hodgkin lymphoma). (wikipedia.org)
  • Several years later at the National Cancer Institute, Roy Hertz and Min Chiu Li then demonstrated complete remission in women with choriocarcinoma and chorioadenoma in 1956, discovering that methotrexate alone could cure choriocarcinoma (1958), a germ-cell malignancy that originates in trophoblastic cells of the placenta. (wikipedia.org)
  • tissues
  • Combining two-photon microscopy with fluorescent tracers, we successfully visualized the engrafted tissues at the single cell level in live mice over several months. (jove.com)
  • Imaging using confocal/two-photon hybrid microscopy enables simultaneous high resolution assessment of uniquely marked cells and their progeny in conjunction with structural components of the tissues. (jove.com)
  • Volumetric analyses over large areas reveal that spectrally coded HSPC-derived cells can be detected non-invasively in various intact tissues, including the bone marrow (BM), for extensive periods of time following transplantation. (jove.com)
  • A category of rare and aggressive haematologic tumors co-expressing CD4 and CD56 antigens in the absence of any specific myeloid, B-, T-lymphoid or natural killer (NK) lineage markers is classified as blastic plasmacytoid dendritic cell neoplasms (BPDCN) according to the most recent 2008 WHO classification of tumours of haematopoietic and lymphoid tissues (1). (czytelniamedyczna.pl)
  • Another kind of cell-the pluripotent stem cell of mouse teratocarcinomas-was found to give rise to normal tissues in adult chimeras after injection into the mouse blastocyst. (thefreedictionary.com)
  • All the differentiated tissues in the tumor arise from pluripotent stem cells known as embryonal carcinoma (EC) cells. (thefreedictionary.com)
  • When embryonal carcinoma cells are injected into a genetically marked host blastocyst, they continue to divide and participate in normal development, and give rise to fully differentiated cells in all tissues of the adult, including skin, muscle, nerve, kidney, and blood. (thefreedictionary.com)
  • Others predispose to autoimmune disease, where the immune system attacks the body's own tissues, or tumours (sometimes specific forms of cancer, such as lymphoma). (wikipedia.org)
  • The diagnosis of CLL is based on the demonstration of an abnormal population of B lymphocytes in the blood, bone marrow, or tissues that display an unusual but characteristic pattern of molecules on the cell surface. (wikipedia.org)
  • tumors
  • The study has currently met its primary end point and is now recruiting patients to be treated at the RD expansion cohort of selected tumor types, specifically: endometrial adenocarcinomas, neuroendocrine tumors, and small-cell lung cancer (SCLC). (careacross.com)
  • 4. Gynecologic tumors (endometrial adenocarcinomas, epithelial ovarian cancer. (careacross.com)
  • Emory interventional radiologists freeze tumors in order to kill cancer cells in contact with the bone and reduce the size of the tumor. (advancingyourhealth.org)
  • Embryonal carcinoma cells from several sources, including spontaneous and embryo-derived tumors and cultured lines selected to carry specific mutations or even human chromosomes, have contributed to normal chimeras. (thefreedictionary.com)
  • The fact that certain embryonal carcinoma cells give rise to tumors when injected under the skin or into the body cavity, but behave normally in the blastocyst, has been used to support the idea that cancers can develop not only as a result of gene mutations but also as a result of disturbances in environmental factors controlling normal cell differentiation (epigenetic theory of cancer). (thefreedictionary.com)
  • this disorder is a form of plasma cell dyscrasia in which no myeloma protein is detected in serum or urine (at least as determined by conventional laboratory methods) of individuals who have clear evidence of an increase in clonal bone marrow plasma cells and/or evidence of clonal plasma cell-mediated tissue injury (e.g. plasmacytoma tumors). (wikipedia.org)
  • In vivo activity against human solid tumors in mice was shown against malignant gynecological tumor cells, like ovarian cancer, and against breast cancer. (wikipedia.org)
  • Among them a phase I trials with solid tumors or leukemias and phase II with non-small-cell lung carcinomas (NSCLC). (wikipedia.org)
  • citation needed] In 1951, Jane C. Wright demonstrated the use of methotrexate in solid tumors, showing remission in breast cancer. (wikipedia.org)
  • Wright's group were the first to demonstrate use of the drug in solid tumors, as opposed to leukemias, which are a cancer of the marrow. (wikipedia.org)
  • malignant
  • The overproduced Ig's, termed myeloma proteins, commonly circulate in blood, may accumulate in urine, and are the hallmarks of plasma cell dyscrasias including their most malignant forms viz. (wikipedia.org)
  • Remissions were brief, but the principle was clear - antifolates could suppress proliferation of malignant cells, and could thereby re-establish normal bone-marrow function. (wikipedia.org)
  • Oncology
  • Through our work with the Children's Oncology Group and other pediatric cancer research groups, we have access to the latest clinical protocols and experimental therapies to give children the best chance for a positive outcome. (wolfsonchildrens.com)
  • In oncology and hematology, a recombinant form of G-CSF is used with certain cancer patients to accelerate recovery and reduce mortality from neutropenia after chemotherapy, allowing higher-intensity treatment regimens. (wikipedia.org)
  • undergo
  • In addition, post-meiotic germ cells undergo a dramatic morphological reshaping process as well as a global epigenetic reconfiguration of the germ line chromatin-the histone-to-protamine switch. (jove.com)
  • Plasma cells develop from B lymphocytes which are stimulated to undergo this maturational development by T lymphocytes during the latter cells' processing of these antigens. (wikipedia.org)
  • The medulla is specialized to allow thymocytes to undergo additional rounds of negative selection to remove auto-reactive T cells from the mature repertoire. (wikipedia.org)
  • endothelial
  • The initial work, published in the JCI in 2000, described the method enabling successful attainment of blood outgrowth endothelial cells (BOEC). (jci.org)
  • Neutropenia
  • This is in contrast to Shwachman-Bodian-Diamond syndrome, in which the bone marrow defect results primarily in neutropenia, and Fanconi anemia, where all cell lines are affected resulting in pancytopenia. (wikipedia.org)
  • pediatric
  • We have one of three federally funded comprehensive hemophilia treatment centers in Florida, as well as a pediatric sickle cell center. (wolfsonchildrens.com)
  • It is home of the nation's first Pediatric Multiple Sclerosis Center.The Heart Center performs the only open-heart surgery in Suffolk and the Cancer Center and Cerebrovascular Center attract patients from throughout the region with cutting edge diagnostic and treatment facilities. (wikipedia.org)
  • The hospital is also the regional referral center for trauma, perinatal and neonatal intensive care, burns, bone marrow and stem cell transplantation, cystic fibrosis, pediatric and adult AIDS, and is the regional resource center for emergency management. (wikipedia.org)
  • proliferation
  • White blood cells The G-CSF-receptor is present on precursor cells in the bone marrow, and, in response to stimulation by G-CSF, initiates proliferation and differentiation into mature granulocytes. (wikipedia.org)
  • ALL emerges when a single lymphoblast gains many mutations to genes that affect blood cell development and proliferation. (wikipedia.org)
  • It seemed to stimulate the proliferation of acute lymphoblastic leukemia (ALL) cells when administered to children with this cancer. (wikipedia.org)
  • Genetic
  • Genetic combinatorial marking using lentiviral vectors encoding fluorescent proteins (FPs) enabled cell fate mapping through advanced microscopy imaging. (jove.com)
  • Blood tests include HLA typing (a test of genetic markers on white blood cells that permit specialized immunology studies). (clinicaltrials.gov)
  • The underlying mechanism involves multiple genetic mutations that results in rapid cell division. (wikipedia.org)
  • Treatment
  • Development of the new methods of treatment of children with acquired and inherited bone marrow failures. (fnkc.ru)
  • Yes to Life was set up specifically to address these shortcomings, and for over a decade it has provided direct support to people with cancer in building and pursuing their own integrative treatment plans. (thecancerrevolution.co.uk)
  • Steven J. Burakoff, MD, is a cancer specialist and the author of both Therapeutic Immunology (2001) and Graft-Vs.-Host Disease: Immunology, Pathophysiology, and Treatment (1990). (wikipedia.org)
  • Before joining Mount Sinai, he was recruited by New York University School of Medicine to revitalize the research and treatment mission of NYU's Cancer Institute, which during his tenure experienced a 31 percent growth and a 50 percent increase in funding from the National Cancer Institute. (wikipedia.org)
  • A phase II trial for the treatment of brain cancers was also reported. (wikipedia.org)
  • Stem cell transplantation may be used if the disease recurs following standard treatment. (wikipedia.org)
  • These concerns led to the discovery of nitrogen mustard, a chemical warfare agent, as an effective treatment for cancer. (wikipedia.org)
  • Although this effect lasted only a few weeks, and the patient had to return for another set of treatment, this was the first step to the realization that cancer could be treated by pharmacological agents. (wikipedia.org)
  • severe
  • In particular, SCID mice and medically immunosuppressed rodents, the common immunologic deficit predisposing these animals to PCP is severe depletion in T-cell function. (binaryinternationalreviews.com)
  • leukemia
  • Chronic lymphocytic leukemia (CLL) is a type of cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell). (wikipedia.org)
  • Central nervous system (CNS) symptoms such cranial neuropathies due to meningeal infiltration are identified in less than 10% of adults and less than 5% of children, particularly mature B-cell ALL (Burkitt leukemia) at presentation. (wikipedia.org)
  • adults
  • Cancer and blood disorder epidemiology in children and young adults in Russian Federation. (fnkc.ru)
  • Although some chimeras do arise naturally, most are produced experimentally, either by mixing cells of very early embryos or by tissue grafting in late embryos or adults. (thefreedictionary.com)
  • HSCs are found in the bone marrow of adults, especially in the pelvis, femur, and sternum. (wikipedia.org)
  • mononuclear cells
  • Other tests are performed depending on the suspected disorder: Quantification of the different types of mononuclear cells in the blood (i.e. lymphocytes and monocytes): different groups of T lymphocytes (dependent on their cell surface markers, e.g. (wikipedia.org)
  • clonal
  • In addition, all the CLL cells within one individual are clonal, that is, genetically identical. (wikipedia.org)
  • In CLL, the lymphocytes are genetically clonal, of the B cell lineage (expressing marker molecules clusters of differentiation 19 and 20), and characteristically express the marker molecules CD5 and CD23. (wikipedia.org)
  • examination
  • Within 4 weeks, candidates who appear eligible for the study will have a physical examination and medical history, an abdominal ultrasound (imaging test using sound waves) to check for cancer of the liver, chest X-ray and electrocardiogram (EKG). (clinicaltrials.gov)
  • Diagnosis is typically based on blood tests and bone marrow examination. (wikipedia.org)
  • lymphocytes
  • CLL results in the build up of B cell lymphocytes in the bone marrow, lymph nodes, and blood. (wikipedia.org)
  • Diagnosis is typically based on blood tests finding high numbers of mature lymphocytes and smudge cells. (wikipedia.org)
  • Normal B lymphocytes consist of a stew of different antibody-producing cells, resulting in a mixture of both kappa- and lambda-expressing cells. (wikipedia.org)
  • These B cells resemble normal lymphocytes under the microscope, although slightly smaller, and are fragile when smeared onto a glass slide, giving rise to many broken cells, which are called "smudge" or "smear" cells. (wikipedia.org)
  • Normal lymphoblasts develop into mature, infection-fighting B-cells or T-cells, also called lymphocytes. (wikipedia.org)
  • germ cells
  • During spermatogenesis in mammals and in Drosophila melanogaster, male germ cells develop in a series of essential developmental processes. (jove.com)
  • They develop spontaneously from germ cells in the gonads of certain mouse strains, or from cells in early embryos transplanted to ectopic sites. (thefreedictionary.com)
  • blood cells
  • Doctors evaluate the results of various blood tests to confirm that new blood cells are being produced and that the cancer has not returned. (stemcellcordblood.net)
  • Misyakes of erythropoiesis Erythropoietin in health The rate of production of red blood cells must be closely regulated because of the huge number of cells involved (3 × 106s). (binaryinternationalreviews.com)
  • Some previously undiagnosed relatives of DBA patients were found to carry mutations, and also had increased adenosine deaminase levels in their red blood cells, but had no other overt signs of disease. (wikipedia.org)
  • Features that support a diagnosis of DBA include the presence of congenital abnormalities, macrocytosis, elevated fetal hemoglobin, and elevated adenosine deaminase levels in red blood cells. (wikipedia.org)
  • These cells do not function well and crowd out healthy blood cells. (wikipedia.org)
  • It must balance enormous production needs (more than 500 billion blood cells are produced every day) with the need to precisely regulate the number of each blood cell type in the circulation. (wikipedia.org)
  • laboratory
  • The retrovirus is now generally called HTLV-I because later studies proved that ATLV is the same as the firstly identified human retrovirus called HTLV discovered by Bernard Poiesz and Francis Ruscetti and their co-workers in the laboratory of Robert C. Gallo at the National Cancer Institute. (wikipedia.org)
  • differentiation
  • This includes differentiation from a stem cell population, mitotic amplification, and meiosis. (jove.com)
  • This atypical molecular pattern includes the coexpression of cell surface markers clusters of differentiation 5 (CD5) and 23. (wikipedia.org)
  • antibodies
  • Tests for T cell function: skin tests for delayed-type hypersensitivity, cell responses to mitogens and allogeneic cells, cytokine production by cells Tests for B cell function: antibodies to routine immunisations and commonly acquired infections, quantification of IgG subclasses Tests for phagocyte function: reduction of nitro blue tetrazolium chloride, assays of chemotaxis, bactericidal activity. (wikipedia.org)