Cancer cells antibody. Medical search. Frequent questions

Generate monoclonal antibodies to the pancreatic cancer stem cell protein DDR1. (ca.gov)
Ferrini S, Cambiaggi A, Cantoni C, Canevari S, Mezzanzanica D, Colnaghi MI and Moretta L: Targeting of T or NK lymphocytes against tumor cells by bispecific monoclonal antibodies: Role of different triggering molecules. (spandidos-publications.com)
Bispecifics are essentially monoclonal antibodies that bind to 2 different targets-that's why we call them bispecific. (ajmc.com)
This review focuses on the engineering of biologics, particularly therapeutic antibodies and their application in preclinical development and clinical trials, as well as approved monoclonal antibodies for the treatment of bladder cancer. (tu-darmstadt.de)
Called monoclonal antibodies, they are also a type of targeted therapy . (medlineplus.gov)
Some monoclonal antibodies work by sticking to cancer cells. (medlineplus.gov)
Other monoclonal antibodies work by blocking signals on the surface of the cancer cell that tell it to divide. (medlineplus.gov)
These cancer-killing substances are attached to the monoclonal antibodies, which then deliver the toxins to the cancer cells. (medlineplus.gov)
Monoclonal antibodies are now used to treat most types of cancer. (medlineplus.gov)
These therapies boost the immune system in more general way than monoclonal antibodies. (medlineplus.gov)
As more effective strategies are needed for patients with refractory non- oncogene -addicted NSCLC, the design of novel clinical trials with ADCs targeting TROP-2 is encouraged as both a monotherapy or combination strategy with existing agents (e.g., monoclonal antibodies targeting immune checkpoint inhibitors or chemotherapy ). (bvsalud.org)
While monoclonal antibodies (mAbs) blocking programmed cell death 1 (PD-1), programmed death-ligand 1 (PD-L1), and cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) have been approved for multiple cancer indications, only a subset of patients benefit from immune checkpoint blockade therapies, highlighting the need for additional approaches. (molecule.to)
Traditional polyclonal and monoclonal antibodies are the product of normal B cell development and genetic recombination. (cellsignal.com)
In contrast, hybridoma-based systems for producing monoclonal antibodies are subject to genetic drift and instability, increasing the potential for lot-to-lot variability or loss of antibody expression. (cellsignal.com)
Antibody-oligonucleotide conjugates or AOCs belong to a class of chimeric molecules combining in their structure two important families of biomolecules: monoclonal antibodies and oligonucleotides. (wikipedia.org)
Combination of exceptional targeting capabilities of monoclonal antibodies with numerous functional modalities of oligonucleotides has been fruitful for a variety of applications with AOC including imaging, detection and targeted therapeutics. (wikipedia.org)
Using immunohistochemistry, radiobinding, and indirect immunofluorescence assays, seven distinct cell surface antigens, detected by monoclonal antibodies, were analyzed for the degree of homogeneity or heterogeneity of antigen expression on A Panel of human small cell lung cancers. (elsevierpure.com)
The heterogeneity of antigen expression on lung cancer cells has significant implications for the use of these and other monoclonal antibodies in the study and therapy of lung cancer. (elsevierpure.com)
Monoclonal antibodies attach to specific proteins or antigens. (who.int)

Castoldi R, Jucknischke U, Pradel LP, Arnold E, Klein C, Scheiblich S, Niederfellner G and Sustmann C: Molecular characterization of novel trispecific ErbB-cMet-IGF1R antibodies and their antigen-binding properties. (spandidos-publications.com)
BCMA is essentially an antigen target that's almost ubiquitously expressed on myeloma cells. (ajmc.com)
It essentially picks up the T cell on the monoclonal antibody and then it binds to the BCMA antigen that's expressed on the myeloma cells. (ajmc.com)
An alternative approach to engage T cells for cancer therapy are antibodies, which are bispecific for a surface target antigen on cancer cells, and for CD3 on T cells. (aacrjournals.org)
These are capable of connecting any kind of cytotoxic T cell to a cancer cell, independently of T-cell receptor specificity, costimulation, or peptide antigen presentation. (aacrjournals.org)
Pioneering work by Kufer and colleagues ( 6 ) showed that CD3/target antigen-bispecific antibodies of this particular design had an exceptionally high potency, and could likewise engage CD8 + and CD4 + T cells for redirected lysis of cancer cells at very low effector to target (E:T) ratios. (aacrjournals.org)
We previously demonstrated an approach (Antibody-antigen Interaction Dependent Apoptosis (AIDA)) whereby a single anti-β-galactosidase intracellular single chain Fv antibody fragment, fused to inactive procaspase-3, induced auto-activation of caspase-3 after binding to the tetrameric β-galactosidase protein. (whiterose.ac.uk)
AIDA can be generally applicable for any target protein inside cells by involving appropriate pairs of antigen-specific intracellular antibodies. (whiterose.ac.uk)
Results AK117 could effectively binds to CD47, and competes with SIRPα for binding to the antigen on Raji cells (figure 1). (bmj.com)
Trophoblastic Cell Surface Antigen 2 (TROP-2) is a surface transmembrane glycoprotein member of the epithelial cell adhesion molecule ( EpCAM ) family . (bvsalud.org)
One way to bring the powerful cellular immunity and antibody directed targeting together is to construct the chimeric antigen receptor (CAR) T-cells. (stanford.edu)
This process involves a functional antigen receptor (B-cell receptor or T-cell receptor) and a dozen of intermediators, including adaptor proteins and kinases that form a network of signaling pathways inside the cells. (stanford.edu)
a chimeric monoclonal antibody against the CD20 antigen increased survival when it was added to chemotherapy for individuals with systemic CD20+ diffuse large B-cell (DLBCL) non-Hodgkin lymphoma (NHL). (ecologicalsgardens.com)
New research shows that an imbalanced response - driven partially by the productive infection of antigen-presenting cells - is associated with progression to severe disease. (nature.com)
Induced pluripotent stem cell (iPSC)-derived macrophages (iMACs) are being used to make chimeric antigen receptor (CAR) macrophages for immunotherapy. (nature.com)
Kwun HJ, Shuda M, Feng H, Camacho CJ, Moore PS, Chang Y. Merkel cell polyomavirus small T antigen controls viral replication and oncoprotein expression by targeting the cellular ubiquitin ligase SCFFbw7. (medscape.com)
In both fresh tumors and in cell lines, as well as in cell lines established from different metastatic sites in an individual Patient, we observed intratumor heterogeneity finding antigen Positive and negative cells and variation in antigenic density, by immunohistochemistry and indirect immunofluorescence assays. (elsevierpure.com)
In addition, when cell lines or Patient samples expressing antigen Positive and antigen negative tumor cells were cloned, heterogeneity of antigenic expression was still Present in the clonal lines. (elsevierpure.com)
This suggests that either the expression of the antigen was not heritable and/or the ability to regenerate antigenic heterogeneity is an intrinsic Property of the tumor cells. (elsevierpure.com)
[ 2 ] Options for second-line therapy in patients with relapsed/refractory disease include chemotherapy-free regimens with biologic targeted agents such as covalent Bruton tyrosine kinase (BTK) inhibitors, lenalidomide,venetoclax, and chimeric antigen receptor (CAR) T-cell therapy. (medscape.com)
Sera from residual specimens from NHANES 2001-2002 participants were tested for levels of IgG antibodies against cancer antigen (CA) 125, CA15.3 and human epididymal secretory protein 4 (HE4). (cdc.gov)

Cancer Treat Rev;118: 102572, 2023 Jul. (bvsalud.org)

In subsequent research, they observed that a human-derived, purified antibody kills tumor cells when bound to a specific target, a protein called complement factor H (CFH), which protects cells from an immune system attack. (fox5dc.com)
The antibody, researchers believe, only recognizes the structurally different part of CFH protein that they believe is only found in tumor cells. (fox5dc.com)
According to Eduard Batlle, this antibody degrades the EGFR protein in cancer stem cells, blocking the growth and survival pathways in cells that expand cancer and develop it. (bayradio.fm)
Antibody and protein technologies came a long way in recent years and new engineering approaches were applied to generate innovative therapeutic entities with novel mechanisms of action. (tu-darmstadt.de)
As many discussed molecules exhibit unique mechanisms of action based on innovative protein engineering, they reflect the next generation of cancer drugs. (tu-darmstadt.de)
In this study, MDA-MB-231 (MDA) triple-negative breast carcinoma cells were used as a tumor cell model and mouse fibroblasts expressing an autophagy marker protein called GFP-LC3, were used as a stroma model. (nature.com)
Free shipping on catalog antibody and protein orders over $999. (abclonal.com)
The recent FDA approvals of the programmed cell death protein 1 (PD-1)-targeted checkpoint inhibitors pembrolizumab and nivolumab mark the latest successes in the rapidly expanding field of cancer immunotherapies. (frontiersin.org)
Moreover, the site-selective modification of the antibody is hardly achievable: due to the difficult production of mAbs the selective introduction of an unnatural amino acid into the protein is not easily possible. (wikipedia.org)
Recently, a novel class of small molecules was developed to inhibit the association of programmed cell death ligand 1 (PD-L1) with its receptor programmed cell death protein 1 (PD-1). (biomedcentral.com)
The K V 10.1-specific scFv62 antibody -TRAIL fusion protein was expressed in CHO-K1 cells, purified by chromatography and tested for biological activity. (biomedcentral.com)
In co-cultures with K V 10.1-positive cancer cells the fusion protein also induced apoptosis in bystander K V 10.1-negative cancer cells, while normal prostate epithelial cells were not affected when present as bystander. (biomedcentral.com)
TRAIL is normally present as a membrane protein (memTRAIL) on immune effector cells, like natural killer cells. (biomedcentral.com)
Carbonic anhydrase IX, or CAIX , is a transmembrane protein whose expression is restricted to very few normal tissues, in particular the membranes of gastric mucosal epithelial cells. (prnewswire.com)
Under hypoxic conditions, hypoxia inducible factor-1 alpha (HIF-1a) is stabilized and the transcription factor HIF-1 transactivates the CA9 gene, resulting in expression of the CAIX protein in the hypoxic cells. (prnewswire.com)
It works by blocking a protein that causes cancer cells to grow and multiply. (chemocare.com)
A therapeutic antibody, brodalumab was designed to block the function of the immune signaling protein interleukin 17 (IL-17). (sciencedaily.com)
Within the past 2 years, investigational peptide- and recombinant protein-based serologic assays that can more easily differentiate the antibodies to HTLV-I and HTLV-II have been developed (8,9). (cdc.gov)
An example of a fusion protein is the drug etanercept , which fuses a cytokine receptor with an antibody. (msdmanuals.com)
The research team has discovered a type of receptor - a protein, located on the surface of the AML stem cells - which sends out signals. (lu.se)
This means that we develop antibodies without knowing the protein target and instead we develop antibodies based on their function. (lu.se)
When you find antibodies with the desired function, then you try to figure out what the actual protein target is afterward, because that's needed before you can enter clinical trials. (lu.se)

As the name suggests, these therapies are manufactured proteins that can bind to 2 separate antigens at the same time, bringing extra power to the fight against cancer. (ajmc.com)
These proteins are called antibodies. (medlineplus.gov)
Autophagy is a cellular homeostatic mechanism where proteins and organelles are digested and recycled to provide an alternative source of building blocks and energy to cells. (nature.com)
Single-chain antibodies (scFv) take an important role in the field, because they are less immunogenic than whole antibodies, their smaller size allows faster and deeper penetration into solid tumors, and are by definition recombinant proteins, therefore easier to produce and modify. (biomedcentral.com)
Interleukin 1 (IL-1) is a name that designates two proteins, IL-1 alpha and IL-1 beta, which are the products of distinct genes, but which show approximately 25% amino acid sequence identity and which recognize the same cell surface receptors. (rndsystems.com)
Furthermore, silibinin inhibited the migration and invasion abilities of YD10B and Ca9-22 cells by regulating the expression of proteins involved in the epithelial-mesenchymal transition. (jcancer.org)
The study drug, brodalumab, is a monoclonal antibody, akin to proteins built by the human immune system to recognize and block specific target molecules. (sciencedaily.com)
In addition, chronic diagnostic test for follow-up of patients cy and for biochemical determination inflammation associated with the infec- with H. pylori gastritis and were able of tissue COX-2 activity using COX tion leads to damage in proteins, the to predict the risk of development of Activity Assay Kit (Cayman Chemical production of reactive oxygen species stomach cancer. (who.int)
They work by recognizing and finding specific proteins or targets on cancer cells. (lu.se)

Researchers extracted the white blood cells from patients who made the antibody, sequenced the antibody genes, and cloned them to make mature antibodies. (fox5dc.com)

Raji cells, HT-29 cells, and HL-60 cells which highly express CD47 were used as target cells to evaluate a pro-phagocytic activity of AK117 as a monotherapy or in combination with anti-EGFR antibody, anti-CD20 antibody or azacitidine. (bmj.com)
AK117 alone or combines with anti-EGFR antibody, anti-CD20 antibody and azacitidine shows potent phagocytosis of tumor cells in a dose-dependent manner (figure 2). (bmj.com)

Clinically relevant improvements in survival have been attained by administering targeted therapy to the appropriate patient population: for example, the addition of trastuzumab to standard first-line chemotherapy in patients with human epidermal growth factor receptor-positive (HER2+) metastatic breast cancer 3 . (ersjournals.com)
In 2017, avelumab became the first drug approved by the FDA for metastatic Merkel cell carcinoma in adults and children aged 12 years or older. (medscape.com)
[ 20 ] In 2018, another PD-1 inhibitor, pembrolizumab, was approved for adults and children with metastatic or recurrent, locally advanced Merkel cell carcinoma. (medscape.com)
Indicated for adults and children with metastatic or recurrent, locally advanced Merkel cell carcinoma. (medscape.com)
The Panel included 7 tumors taken directly from Patients, 21 established cell lines (9 of which were derived from different metastatic sites of 3 Patients), and 33 clonal derivatives of 3 lines. (elsevierpure.com)
You have metastatic breast cancer (breast cancer that has spread beyond the original tumour) with high levels of HER2. (who.int)
BT-ON014 trade name] may be given with another cancer medicine, paclitaxel or docetaxel, as first treatment for metastatic breast cancer, or it may be used alone if other treatments have proved unsuccessful. (who.int)
BT-ON014 trade name] is also used in combination with medicines called aromatase inhibitors with patients with high levels of HER2 and hormone receptor-positive metastatic breast cancer (cancer that is sensitive to the presence of female sex hormones). (who.int)
Interestingly, the level of SA expression is increased on metastatic cancer cells. (lu.se)
We perform molecular and functional studies of primary and metastatic tumor cells, as well as in vitro and in vivo drug testing using PDXs as model system. (lu.se)

Now, the same process is used for making amivantamab as well: 1 [antibody] targets EGFR and 1 targets c-MET. (ajmc.com)
Amivantamab, though, targets EGFR and c-Met, so it's not redirecting T cells. (ajmc.com)
And then there's a variety of immune-type mechanisms by which binding of EGFR or binding of c-Met separately kills the cancer cell. (ajmc.com)
But we've learned over the last 10-plus years that in many EGFR lung cancers, one primary mechanism of resistance is through c-Met. (ajmc.com)
On the other hand, in brain tumors, such as glioma and glioblastoma, CSCs have instead been identified using cell surface markers, including SSEA-1 20 , EGFR 21 , and CD44 22 . (atlasantibodies.com)
Likewise, bispecific antibodies for engagement of other cytotoxic immune cells were constructed, for instance, targeting Fcγ RI/CD64 on macrophages and Her2/neu or EGFR on tumor cells. (aacrjournals.org)
Promising activity of novel ADCs, namely Trastuzumab Deruxtecan and Patritumab Deruxtecan, has been observed in hard-to treat molecular subtypes, such as HER2-positive and heavily pretreated EGFR-mutant Non-Small Cell Lung Cancer (NSCLC). (bvsalud.org)
What role should anti-EGFR antibodies play in NSCLC treatment, and in which patients? (ersjournals.com)
This review considers the current evidence linking biomarker profile to efficacy of epidermal growth factor receptor (EGFR)-targeted therapy in advanced nonsmall cell lung cancer (NSCLC) and the clinical implications of recent findings. (ersjournals.com)
Detection of EGFR mutations with mutation-specific antibodies in stage IV non-small-cell lung cancer. (ox.ac.uk)

Arlotta KJ and Owen SC: Antibody and antibody derivatives as cancer therapeutics. (spandidos-publications.com)
Besides, newly emerging entities in the realm of bladder cancer like mRNA, gene therapy or cell-based therapeutics are discussed and evaluated. (tu-darmstadt.de)
Efforts at using NK cells as antitumor agents began over two decades ago, but recent advances in elucidating NK cell biology have accelerated the development of NK cell-targeting therapeutics. (frontiersin.org)
Cell uptake/internalisation still represents the biggest hurdle towards successful ON therapeutics. (wikipedia.org)
Being adapted from the broad and successful class of Antibody-Drug conjugates, antibodies and antibody analogues are more and more used in research in order to overcome hurdles related to delivery and internalisation of ON therapeutics. (wikipedia.org)

A therapeutic antibody to DDR1 for targeting pancreatic cancer stem cells to overcome resistance to chemotherapy and potentiate the treatment of advanced cancer. (ca.gov)
PDAC is lethal cancer that poorly responds chemotherapy to which it becomes resistant. (ca.gov)
We will develop on antibody for destroying PDAC stem cells and preventing resistance to standard chemotherapy. (ca.gov)
Another type of monoclonal antibody carries radiation or a chemotherapy drug to cancer cells. (medlineplus.gov)
Antibody drug conjugates (ADCs) represent a revolutionary drug class in cancer therapy , combining the precision of targeted therapy with the cytotoxic effects of chemotherapy . (bvsalud.org)
However, therapeutic advances are expected in certain subgroups of lung cancer patients , including non- oncogene -addicted NSCLC after failure of current standard of care (e.g., immunotherapy with or without chemotherapy , chemo-antiangiogenic treatment ). (bvsalud.org)
Hormone therapy is a treatment option for advanced prostate cancer, as are chemotherapy and immunotherapy . (medicalnewstoday.com)
This is not uncommon as chemotherapy can affect healthy cells as well as cancer cells. (chemocare.com)
In this open-label, phase 3 trial, we randomly assigned 305 patients who had previously untreated advanced NSCLC with PD-L1 expression on at least 50% of tumor cells and no sensitizing mutation of the epidermal growth factor receptor gene or translocation of the anaplastic lymphoma kinase gene to receive either pembrolizumab (at a fixed dose of 200 mg every 3 weeks) or the investigator's choice of platinum-based chemotherapy. (nih.gov)
In patients with advanced NSCLC and PD-L1 expression on at least 50% of tumor cells, pembrolizumab was associated with significantly longer progression-free and overall survival and with fewer adverse events than was platinum-based chemotherapy. (nih.gov)
Limited-stage cancer is treated with chemotherapy and radiation. (medscape.com)
Extensive-stage cancer is treated with chemotherapy alone. (medscape.com)
Because cancer cells divide faster than normal cells, they are more affected by chemotherapy compared to healthy cells", explains Helena Ågerstam, cancer researchers at Lund University. (lu.se)
Because stem cells multiply slowly, chemotherapy does not have a sufficient impact on them, which explains why two-thirds of these patients relapse. (lu.se)

Their primary antibodies and secondary antibodies are created through a process involving extensive research, development and validation. (prnewswire.com)
GeneTex has over 55,000 primary antibodies in its catalog that are all backed by a 100% Satisfaction Guarantee. (prnewswire.com)

Here, we review the principle of a new class of bispecific antibodies called BiTE (for "bispecific T-cell engager") antibodies. (aacrjournals.org)
This mode of action is being referred to as BiTE for "bispecific T-cell engager" technology. (aacrjournals.org)

Targeting pancreatic cancer stem cells with DDR1 antibodies. (ca.gov)
Confirm that these antibodies preferentially target and destroy pancreatic cancer stem cells. (ca.gov)
Confirm that these antibodies shrink human pancreatic cancers cells grown in mice by killing pancreatic cancer stem cells. (ca.gov)
Cancer stem cells (CSCs) are small cells, 1% to 3% of all cells in a tumor, that drive the tumor's initiation, growth, and metastasis and may cause relapse. (atlasantibodies.com)
Among all cancerous cells, a few act as stem cells that reproduce and sustain the tumor, much like stem cells normally renew and sustain our organs and tissues. (atlasantibodies.com)
Cancer stem cells (CSCs) are generated by a combination of DNA mutations, epigenetic events, and tissue microenvironment factors from normal stem cells or precursor/progenitor cells, to which they are closely related and share many of the behaviors and features 1 . (atlasantibodies.com)
The existence of stem cells in hematological tissue prompted research in other tissue cancer types. (atlasantibodies.com)
They are commonly expressed in pluripotent embryonic stem cells, germ cells, certain committed progenitors, and cancer cells 18 . (atlasantibodies.com)
An international consortium led by Eduard Batlle, a scientist at the Biomedical Research Institute (IRB) in Barcelona, has discovered the MCLA-antibody158, the first drug candidate targeting solid tumor cancer stem cells that prevents the spread of cancer and its metastasis. (bayradio.fm)
Batlle, head of the IRB's Colorectal Cancer laboratory, in a collaboration with biotech company Merus N.V., have published in the journal 'Nature Cancer' the preclinical data that have led to the discovery of the MCLA-158 and its mechanism of action in cancer stem cells. (bayradio.fm)
We started researching cancer stem cells 15 years ago. (bayradio.fm)
This antibody also does not interfere with the functioning of healthy stem cells in the body, which are essential for the proper functioning of tissues," adds Batlle. (bayradio.fm)
Targeted antibodies that prevent leukaemia stem cells from multiplying while attracting the natural killer cells of the body, which in turn send a death signal to the diseased stem cell. (lu.se)
However, the AML stem cells, which are located in the bone marrow and are responsible for producing cancer cells, are hard to affect. (lu.se)
This receptor, called (IL1RAP), cannot be found on healthy blood stem cells, which opens up the possibility for a selective attack on the diseased stem cells using antibodies. (lu.se)

Immune checkpoint inhibitors are a newer type of monoclonal antibody that act on these checkpoints to boost the immune system so it can attack cancer cells. (medlineplus.gov)
PD-1 and PD-L1 inhibitors are used to treat a variety of different cancer types. (medlineplus.gov)
Cytokines, cancer vaccines, adoptive cell transfers, and especially checkpoint inhibitors constitute valuable elements in the immunotherapeutic armamentarium. (frontiersin.org)
Thus, PD-L1 inhibitors prevent cancer cells from evading the immune system. (biomedcentral.com)

During ASCO, Janssen presented results from the CHRYSALIS study on amivantimab, a bispecific antibody being developed to treat non-small cell lung cancer (NSCLC). (ajmc.com)
Two bispecific antibodies in development, amivantamab for NSCLC and teclistamab for multiple myeloma, have some similarities, but one is being developed for a solid tumor and the other for hematologic cancer. (ajmc.com)
For lung cancers, CSC markers include CD44 and CD133 (PROM1), but also CD117 (KIT), CD90 (or THY1), CD166, EpCAM for non-small-cell lung carcinoma (NSCLC), and PODXL-1, PTCH, and CD87 for small-cell lung carcinoma (SCLC) 25 . (atlasantibodies.com)
Clinically, lung cancers are often categorized into SCLC and non-SCLC ( NSCLC ). (medscape.com)
TROP-2 directed antibody-drug conjugates (ADCs): The revolution of smart drug delivery in advanced non-small cell lung cancer (NSCLC). (bvsalud.org)
The principle of preferentially selecting patients most likely to benefit from therapy according to their genetic profile has led to substantial clinical benefit in some tumour types, and has potential to considerably refine treatment in advanced nonsmall cell lung cancer (NSCLC). (ersjournals.com)
Pembrolizumab is a humanized monoclonal antibody against programmed death 1 (PD-1) that has antitumor activity in advanced non-small-cell lung cancer (NSCLC), with increased activity in tumors that express programmed death ligand 1 (PD-L1). (nih.gov)

The concept of using such bispecific antibodies to engage cytotoxic T cells for cancer cell lysis was shown by Staerz and colleagues ( 1 ). (aacrjournals.org)
BiTE ® antibodies are novel recombinant single chain Ig domain constructs that leverage the endogenous cytotoxic potential of polyclonal T cells to target malignant cells by utilizing the specific binding properties of variable domains from two different antibodies. (biomedcentral.com)
The most advanced BiTE ® antibody, Blinatumomab, directs cytotoxic T cells to CD19-expressing target cells. (biomedcentral.com)
PD-L1 is expressed on tumor cells and interacts with PD-1 on cytotoxic T-cells, leading to reduced T-cell function and thereby lower anti-tumor activity of the host's immune system [ 1 ]. (biomedcentral.com)
After sensitization with cytotoxic drugs, scFv62-TRAIL induced apoptosis only in K V 10.1-positive cancer cells, but not in non-tumor cells, nor in tumor cells lacking K V 10.1 expression. (biomedcentral.com)
PD-L1/PD-1 interaction inhibits immune activation and reduces T-cell cytotoxic activity when bound. (medscape.com)

Because these are bipartite with variable fragments (Fv) coming from two different genes, a linker sequence was introduced in order to align the two variable domains on a single polypeptide chain, resulting in a so-called single-chain antibody (scFv) (ref. 5 ). (aacrjournals.org)
We designed a single-chain antibody against an extracellular region of K V 10.1 (scFv62) and fused it to the human soluble TRAIL. (biomedcentral.com)

Cancer Research Communications (2022) 2 (8): 772-783. (aacrjournals.org)
Blood cancer discovery 2022 0 0. (cdc.gov)
Cancers 2022 0 0. (cdc.gov)
Infectious agents and cancer 2022 0 0. (cdc.gov)
Cancer cell 2022 0 0. (cdc.gov)

This enabled combination with an additional linker sequence of two single-chain antibodies of different binding specificity in tandem, in such a way that four gene products are ultimately aligned on a single polypeptide chain of approximately 55 kDa ( Fig. 1 ). (aacrjournals.org)
At CST, we adhere to the Hallmarks of Antibody Validation™ , six complementary strategies for determining the specificity, sensitivity, and functionality of an antibody in any given assay. (cellsignal.com)
Thats why there is intensive research to exploit antibody analogues and antibody fragments which retain a high target specificity but combined with a smaller size and a greater possibility of modification. (wikipedia.org)

They could prove the functionality of both entities in the construct and by screening different antibodies, they validated their importance for an effective antisense effect. (wikipedia.org)

When these cells die, they release substances called antigens. (medlineplus.gov)
These antigens tell the immune system to target and kill other cancer cells in the body. (medlineplus.gov)
In addition, the licensed screening tests, which use HTLV-I antigens, vary in their sensitivity to detect antibodies to HTLV-II (4,5). (cdc.gov)
Tumor antigens After a cell becomes cancerous, the immune system is often able to recognize it as abnormal and destroy it before it replicates or spreads. (msdmanuals.com)

What is a Recombinant Antibody and Why is it Important? (cellsignal.com)
What is a Recombinant Antibody? (cellsignal.com)
Mammalian cell lines are most commonly used for recombinant antibody production, although cell lines of bacterial, yeast, or insect origin are also suitable. (cellsignal.com)
Because recombinant antibody production involves sequencing the antibody light and heavy chains, it is a highly controlled and reliable process. (cellsignal.com)
Nicholas Hutchings will discuss how recombinant antibody technology can speed up the response to a pandemic. (the-scientist.com)

The presence of antibodies to HTLV-I or HTLV-II indicates that a person is infected with the virus. (cdc.gov)
The study used cell culture adaptation to decipher how HCV might improve its ability to enter and infect cells in the absence or presence of antibodies. (who.int)

Kamakura D, Asano R and Yasunaga M: T cell bispecific antibodies: An antibody-based delivery system for inducing antitumor immunity. (spandidos-publications.com)
BiTE antibodies consistently show a high potency of redirected lysis in vitro , and high antitumor activity in various animal models. (aacrjournals.org)
Given that CD155 is highly expressed by both human and mouse tumors and tumor-infiltrating myeloid cells, it has been proposed that TIGIT might inhibit antitumor immune responses via multiple, sequential steps: first, inhibiting NK cell-mediated tumor cell killing as well as tumor Ag release, then inducing tolerogenic dendritic cells and suppressing CD8+ T cell function via TIGIT+ Tregs, and finally directly inhibiting CD8+ T cell effector functions. (molecule.to)
Here, we review tumor-NK cell interactions, discuss the mechanisms by which NK cells generate an antitumor immune response, and discuss NK cell-based therapeutic strategies targeting activating, inhibitory, and co-stimulatory receptors. (frontiersin.org)
instead of targeting tumor cells, the goal of immunotherapy is to augment and expand the immune system's intrinsic antitumor response. (frontiersin.org)
An important class of innate immune cells that play a critical role in mediating the antitumor immune response is the natural killer (NK) cell. (frontiersin.org)
Antitumor activity of a monoclonal antibody directed against gastrin-releasing peptide in patients with small cell lung cancer. (rush.edu)
Pembrolizumab had an acceptable side-effect profile and showed antitumor activity in patients with advanced non-small-cell lung cancer. (nih.gov)

Among them, TaKE1‑Fc was predicted to form a circular tetrabody‑like configuration and exhibited the highest production and greatest cancer growth inhibitory effects. (spandidos-publications.com)
The resulting TaKE1 exhibited trispecificity via its ability to bind cancer cells, T cells and NK cells, as well as comparable or greater cancer growth inhibitory effects to those of two bispecific antibodies that recruit T cells and NK cells, respectively. (spandidos-publications.com)
CD47 serves as the ligand for a receptor on these innate immune cells, SIRPα, which in turn delivers an inhibitory signal for phagocytosis. (bmj.com)
Tumors escape immune surveillance by inducing various immunosuppressive pathways, including the activation of inhibitory receptors on tumor-infiltrating T cells. (molecule.to)
NK cell activation and the triggering of effector functions is governed by a complex set of activating and inhibitory receptors. (frontiersin.org)

Recently, anti-TIGIT mAb (tiragolumab) has demonstrated promising clinical efficacy in non-small cell lung cancer treatment when combined with an anti-PD-L1 drug (Tecentriq), leading to phase III trial initiation. (molecule.to)
BiTE ® antibodies have demonstrated efficacy in hematologic malignancies, both preclinically and clinically. (biomedcentral.com)
We assessed the efficacy and safety of programmed cell death 1 (PD-1) inhibition with pembrolizumab in patients with advanced non-small-cell lung cancer enrolled in a phase 1 study. (nih.gov)
PD-L1 expression in at least 50% of tumor cells correlated with improved efficacy of pembrolizumab. (nih.gov)

Small cell lung carcinoma (SCLC) arises in peribronchial locations and infiltrates the bronchial submucosa. (medscape.com)

We could design a strategy that selectively kills tumor cells based on a K V 10.1-specific antibody. (biomedcentral.com)

NK cell infiltration into tumor tissue is associated with better disease prognosis in colorectal cancer, clear cell renal cell carcinoma, and lung carcinomas ( 9 - 11 ). (frontiersin.org)
PANITUMUMAB (pan i TOOM ue mab) treats colorectal cancer. (chemocare.com)

The functional relevance of CD33 expression levels was shown by faster lysis kinetics of CD33 BRIGHT versus CD33 DIM AML cell lines and primary AML cells in ex-vivo cytotoxicity assays. (biomedcentral.com)
Although we observed a reduction in the levels of antibodies over time, the results of our neutralizing assays have shown a robust neutralization activity for up to the seventh month post-infection in a large proportion of previously virus-positive screened subjects," explains Marc Veldhoen. (medicalxpress.com)
The effects of silibinin on the migration and invasion of oral cancer cells were evaluated using transwell assays. (jcancer.org)

After development of the SMCC based conjugates, there were two constructs reported in literature based on strain-promoted alkyne-azide cycloadditions: an MXD3 mRNA targeting gapmer (cEt and PS modified) linked to an anti-CD22 antibody targeting preB cells leads to in-vitro apoptosis of targeted cells and in-vivo increased length of mouse survival in xenograft models. (wikipedia.org)
The tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a promising candidate for the design of bifunctional antibodies. (biomedcentral.com)
Flow cytometry was used to examine apoptosis, cell cycle distribution, and accumulation of reactive oxygen species (ROS). (jcancer.org)
Moreover, it induced cell cycle arrest in the G0/G1 phase, apoptosis, and ROS generation in these cells. (jcancer.org)
Silibinin considerably reduced the development of oral cancer cells by inducing apoptosis, G 0 /G 1 arrest, ROS generation, and activation of the JNK/c-Jun pathway. (jcancer.org)

MCLA-158 is capable of blocking the onset of metastasis and cancer growth. (bayradio.fm)
Little cell lung cancer (SCLC) metastasizes widely, but palatine tonsil can be an extremely uncommon site for metastasis. (thetechnoant.info)
Malignant growth of epithelial cells tending to infiltrate the surrounding tissue and giving rise to metastasis. (digitalnaturopath.com)
Our overall aims are to unravel mechanisms leading to metastasis and treatment resistance of childhood cancer neuroblastoma, and to test compounds targeting aggressive neuroblastoma. (lu.se)

The antibody was then tested in multiple cancer cell lines, including lung, gastric and breast cancers in lab dishes and in tumors in living mice. (fox5dc.com)

More than 25 years ago, monoclonal antibody and recombinant DNA technologies enabled the construction of antibody-based molecules that normally do not occur in nature. (aacrjournals.org)
The first bispecific antibodies looked like normal immunoglobin G (IgG) molecules but had their two binding arms equipped with distinct binding specificities. (aacrjournals.org)
Checkpoints" are specific molecules on certain immune cells that the immune system either turns on or turns off to create an immune response. (medlineplus.gov)
Cytokines transmit their message by attaching to specific molecules called receptors on the surface of another cell. (msdmanuals.com)

Therapies tailored to specific genetic lesions and diagnostic tests that assay for their respective molecular targets are now an established part of clinical practice across various tumour types, including chronic myeloid leukaemia 1 , gastrointestinal stromal tumours and epithelial tumours, such as breast and colon cancer 2 . (ersjournals.com)
A quality control (QC) pooled sample was generated from pooling equal volumes of serum samples from ovarian cancer cases and split aliquots of the QC pool were tested at three different dilutions (2, 10, 50 and 250-fold) in triplicate on each assay plate to determine intra- and inter-assay variation. (cdc.gov)
Since then, all donations of whole blood and blood components in the United States have been screened for antibodies to HTLV-I. The screening tests that were licensed, as well as the investigational supplementary tests used to confirm seroreactivity (Western immunoblot and radioimmunoprecipitation assay), do not reliably differentiate between antibodies to HTLV-I and the closely related HTLV-II. (cdc.gov)

SCLC, previously known as oat cell carcinoma, is considered distinct from other lung cancers, which are called non-small cell lung cancers (NSCLCs) because of their clinical and biologic characteristics. (medscape.com)
Historically, the histologic identification of small cell cancer dates back to the 1920s, when the small cell/oat cell tumor was shown to be a carcinoma of the lung and not an oat cell sarcoma of the mediastinum, as thought earlier. (medscape.com)
Merkel Cell Carcinoma of the Head and Neck: Recommendations for Diagnostics and Treatment. (medscape.com)
Effect of radiation therapy on survival in patients with resected Merkel cell carcinoma: a propensity score surveillance, epidemiology, and end results database analysis. (medscape.com)
Diagnosis and treatment of Merkel cell carcinoma. (medscape.com)
Merkel cell carcinoma. (medscape.com)
Available at https://www.mayoclinic.org/diseases-conditions/merkel-cell-carcinoma/symptoms-causes/syc-20351030 . (medscape.com)
Merkel cell carcinoma: prevention. (medscape.com)
Available at https://my.clevelandclinic.org/health/diseases/17971-merkel-cell-carcinoma/prevention . (medscape.com)
Merkel cell carcinoma: changing incidence trends. (medscape.com)
Uitentuis SE, Louwman MWJ, van Akkooi ACJ, Bekkenk M. Treatment and survival of Merkel cell carcinoma since 1993: a population-based cohort study in the Netherlands. (medscape.com)
Clonal integration of a polyomavirus in human Merkel cell carcinoma. (medscape.com)
MicroRNA Expression Patterns Related to Merkel Cell Polyomavirus Infection in Human Merkel Cell Carcinoma. (medscape.com)
Faust H, Andersson K, Ekström J, Hortlund M, Robsahm TE, Dillner J. Prospective study of Merkel cell polyomavirus and risk of Merkel cell carcinoma. (medscape.com)
Merkel cell carcinoma: two case reports focusing on the role of fluorodeoxyglucose positron emission tomography imaging in staging and surveillance. (medscape.com)
Squamous Cell Carcinoma ( SCC ) accounts for about 20% of skin cancers, and occurs mainly on sun-exposed surfaces, although with a slightly different distribution. (digitalnaturopath.com)
For example, SCC is relatively more common on the ears, hands, arms, and legs than Basal Cell Carcinoma ( BCC ). (digitalnaturopath.com)
Squamous Cell Carcinoma. (digitalnaturopath.com)
Basal Cell Carcinoma. (digitalnaturopath.com)
Squamous cell cancer also presents as a central lesion, but unlike small cell carcinoma, it frequently exhibits central cavitation. (medscape.com)
High-power photomicrograph of small cell carcinoma on the left side of the image with normal ciliated respiratory epithelium on the right side of the image. (medscape.com)
Of all histologic types of lung cancer, SCLC and squamous cell carcinoma have the strongest correlation to tobacco. (medscape.com)
Separate worldwide data for small cell carcinoma are not available. (medscape.com)

A functional trispecific antibody with the potential to exert strong therapeutic effects independent of T cell and NK cell populations was developed. (spandidos-publications.com)
The defining functional feature of NK cells remains their intrinsic ability to conduct "natural killing" of cellular targets without prior sensitization. (frontiersin.org)

The emerging approach to cancer treatment holds promise as an alternative to existing immunotherapies that pose unwanted side effects, researchers said. (fox5dc.com)
The pharma giant, along with its parent company, Johnson & Johnson (J&J), had previously received a breakthrough therapy designation in December for teclistamab, another bispecific antibody indicated for potential treatment of multiple myeloma. (ajmc.com)
In addition, CSCs might give rise to metastases, acting as a reservoir of cancer cells, causing relapse after the surgery or treatment has eliminated the visible signs of cancer. (atlasantibodies.com)
Recent results from clinical studies with a CD19/CD3-bispecific BiTE antibody suggest that this therapeutic paradigm is finally showing promise for treatment of both bulky and minimal residual disease. (aacrjournals.org)
Because SCLC is considered a systemic disease, the clinical course, prognosis, and treatment options are clearly different from those of other lung cancers. (medscape.com)
Immunotherapy is a type of cancer treatment that relies on the body's infection-fighting system (immune system). (medlineplus.gov)
The side effects for different types of immunotherapy for cancer differ by the type of treatment. (medlineplus.gov)
Anti-PD-L1 therapy prevents cancer cells from evading the immune system and has emerged as a new treatment option in several cancer entities. (biomedcentral.com)
In this episode, the doctors delve into what Minimal/Measurable Disease (MRD) is, which blood cancers testing is currently used on, and how we can utilize it to more accurately monitor patients and customize treatment. (stanford.edu)
In order to monitor disease after a curative treatment such as allogeneic transplant, pioneer works from Drs. David Miklos and Wen-Kai Weng have established the utility of high-throughput sequencing (HTS) of either B-cell receptor (BCR) or T-cell receptor (TCR) in monitoring minimal residual disease (MRD). (stanford.edu)
Antibodies have become essential in the diagnostic and therapeutic field and form one of the biggest classes of new drugs approved for the treatment of cancer in the last decade [ 3 ]. (biomedcentral.com)
and is Principal of and holds stock in Axxia Pharmaceuticals LLC which is definitely developing a patent re: Subcutaneous hydromorphone implant for the treatment of cancer pain. (ecologicalsgardens.com)
The Eggplant Cancer Cure - A Treatment for Skin Cancer and New Hope for Other Cancers From Natures Pharmacy by Dr. Bill E. Cham, Ph.D. (digitalnaturopath.com)
Treatment with an eggplant extract, discussed in this book, and elsewhere on the Internet, has proven highly effective in curing skin cancers other than melanomas. (digitalnaturopath.com)
Curaderm BEC5 Cream is the revolutionary skin cancer treatment which is becoming the topic of discussion in health food stores, doctor's offices and at the dinner table. (digitalnaturopath.com)
Next, we investigated the molecular processes underlying both in vitro and in vivo outcomes of silibinin treatment on oral cancer. (jcancer.org)
Our findings indicate that silibinin may be a promising option for the prevention or treatment of oral cancer. (jcancer.org)
Although treatment for oral cancer has improved over the years, the disease still proves fatal to a large number of patients. (jcancer.org)
if you have severe breathing problems at rest due to your cancer or if you need oxygen treatment. (who.int)
Treatment selection takes into account patient age, fitness, and whether autologous stem cell transplantation (ASCT) is planned. (medscape.com)
Also, see the Clinical Presentations of Lung Cancer: Slideshow and Lung Cancer Staging -- Radiologic Options slideshows for additional information on SCLC staging and treatment. (medscape.com)
The standard treatment of AML is to apply cytostatic drugs which damage the genome of growing cells, preventing them from multiplying. (lu.se)

However, as tumors progress, cancerous cells develop immunosuppressive mechanisms that circumvent NK cell-mediated killing, allowing for tumor escape and proliferation. (frontiersin.org)
To date, diverse immunotherapeutic modalities have been accepted as viable strategies for eliminating cancerous cells. (frontiersin.org)
In some instances, the cancerous cells can spread to other body parts through tissue, the blood, or the lymphatic system. (medicalnewstoday.com)
Doctors will test any cancerous cells in the body to determine if the additional cells came from the prostate. (medicalnewstoday.com)
A doctor will typically recommend imaging scans and tissue samples to test for the presence of cancerous cells. (medicalnewstoday.com)

We stained a tissue microarray consisting of 170 patients, including 72 intrahepatic cholangiocarcinomas (iCCAs), 57 perihilar cholangiocarcinomas (pCCAs) and 41 distal cholangiocarcinomas (dCCAs) by immunohistochemistry and evaluated PD-L1 positivity in tumor and stromal cells. (biomedcentral.com)
GeneTex is proud to introduce a superior monoclonal antibody against CAIX that has been fully validated through immunohistochemistry, immunofluorescence, western blotting and FACS. (prnewswire.com)

American Type Culture Collection) for detection of antibodies against SVA (B. Guo, unpub. (cdc.gov)
The availability of specific antibodies against SA is limited and, therefore, biomarker tools for detection of SA are lacking. (lu.se)
These results show that SA-MIP can be used as a plastic antibody for detection of SA using both flow cytometry and fluorescence microscopy. (lu.se)

Examples of hematologic cancer include leukemia, lymphoma, and multiple myeloma. (atlasantibodies.com)
Hematologic cancers begin in the cells of the immune system or in blood-forming tissue, such as the bone marrow. (cdc.gov)
Common types of hematologic cancer are lymphoma, myeloma, and leukemia. (cdc.gov)
Estimated 5-year Limited Duration Prevalence Counts for Malignant Hematologic Cancer, by Sex and Cancer Type a . (cdc.gov)
a This table shows the estimated number of people alive as of January 1, 2019, who were diagnosed with a malignant hematologic cancer from January 1, 2014, to December 31, 2018. (cdc.gov)
Antibody Response in Immunocompromised Patients With Hematologic Cancers Who Received a 3-Dose mRNA-1273 Vaccination Schedule for COVID-19. (cdc.gov)

There are several types of immunotherapy for cancer. (medlineplus.gov)
Here the authors review CAR T cell engineering and immunotherapy for cancer and juxtapose state-of-the-art developments with CAR NK cells as part of our Cancer Immunology series of Reviews. (nature.com)
Immunotherapy for Cancer Immunotherapy is used to stimulate the body's immune system against cancer. (msdmanuals.com)

Bispecific antibodies received plenty of attention at last year's meeting of the American Society of Hematology, and the momentum continued in late May during the virtual annual meeting of the American Society Society of Clinical Oncology (ASCO). (ajmc.com)

The technology and improved, newly developed BiTE antibodies are described in recent review articles ( 9, 10 ). (aacrjournals.org)
It once accounted for 20-25% of all newly diagnosed lung cancers. (medscape.com)

Having generated a research cell bank producing a monoclonal antibody with a yield and characteristics usual and customary of the industry standards, the risks of developability is vastly reduced. (molecule.to)
These treatments target specific genetic characteristics of the tumor cells. (msdmanuals.com)
See Small Cell Lung Cancer: Beating the Spread , a Critical Images slideshow, to help identify the key clinical and biologic characteristics of small cell lung cancer, the staging criteria, and the common sites of spread. (medscape.com)
New insights into genetic characteristics between multiple myeloma and COVID-19: An integrative bioinformatics analysis of gene expression omnibus microarray and the cancer genome atlas data. (cdc.gov)

To that end, Janssen has 6 bispecific antibodies in development-all first-in-class therapies. (ajmc.com)
Many new anti-cancer therapies are evaluated based on their ability to shrink tumors. (atlasantibodies.com)
Resistance against conventional therapies is particularly relevant in prostate cancer [ 1 ]. (biomedcentral.com)
One of such modifications rendering novel strategies for antibody-based therapies is the fusion to an effector molecule, to generate so-called bifunctional antibodies. (biomedcentral.com)

Small cell lung cancer (SCLC) accounts for approximately 13-15% of all cases of lung cancer. (medscape.com)
Contrast-enhanced MRI of the brain in a patient with known small-cell lung cancer (SCLC). (medscape.com)
In 1998, the International Association for the Study of Lung Cancer (IASLC) classified SCLC into 3 general histologic subtypes: small, mixed, and combined. (medscape.com)
The combined variety includes a significant proportion of squamous cell or adenocarcinoma cell cancers in addition to small cell cancers (1-3% of cases of SCLC). (medscape.com)
INTRODUCTION Small cell lung malignancy (SCLC) is highly malignant neoplasm, derived from neuroendocrine cells. (thetechnoant.info)
Fewer than 5% of patients with small cell lung cancer (SCLC) are asymptomatic at presentation. (medscape.com)
SCLC is an aggressive subtype of lung cancer. (medscape.com)
The predominant cause of small cell lung cancer (SCLC) (and non-SCLC) is tobacco smoking. (medscape.com)
All types of lung cancer occur with increased frequency in uranium miners, but SCLC is the most common. (medscape.com)
The incidence of small cell lung cancer (SCLC) has declined over the last few years. (medscape.com)

Researchers observed that the antibodies inhibited tumor growth without obvious side effects. (fox5dc.com)
It then impacts tumor growth by disabling the protective CPH layer and destroying cancer cells. (fox5dc.com)
There is increasing evidence that T cells are able to control tumor growth and survival in cancer patients, both in early and late stages of the disease. (aacrjournals.org)

Here, the authors show that combining γ9δ2 TCR-mediated metabolic and co-stimulatory stress targeting by chimeric NKG2D or anti-CD277 co-receptors shapes transcriptomic heterogeneity of engineered T cells and is associated with improved control of solid tumors. (nature.com)

After cloning the antibody genes into an expression vector, this is then transfected into an appropriate host cell line for antibody expression. (cellsignal.com)
Studies have been conducted in our laboratory to determine whether exposure to TCA causes alterations in expression of cancer related genes in cultured human cells. (cdc.gov)
Alterations in expression include metabolic genes (CYP11B1, MGMT), cell cycle control and DNA repair genes (GADD45, Cyclin G2, Cyclin D3, Cyclin A) and transcription factors (IF2, IF3). (cdc.gov)

This sequence of steps may ultimately prevent elimination of cancer cells, so TIGIT is considered to be a key inhibitor in cancer immunity. (molecule.to)
Only recently the first examples for a site-selective conjugation between an ON therapeutic and a mAb was published: in 2015 Genentech exploited the SMCC linker to conjugate siRNA to several engineered mAb based on their proprietary Thiomab technology, which allows site-specific introduction of a cysteine into the antibody sequence[32]. (wikipedia.org)
Neither precursor contains a typical hydrophobic signal peptide sequence and most of the precursor form of IL-1 alpha remains in the cytosol of cells, although there is evidence for a membrane-bound form of the precursor form of IL-1 alpha. (rndsystems.com)
Among various species, the amino acid sequence of mature IL-1 alpha is conserved 60% to 70% and human IL-1 has been found to be biologically active on murine cell lines. (rndsystems.com)
BT-ON014 trade name] may be combined with other cancer medicines, and is usually part of a sequence of treatments that may also include surgery or radiotherapy. (who.int)

Here we provide an overview of the most prominent CSC markers, focusing on solid cancers (lung, stomach, liver, breast, and colorectal cancers) and hematological cancers (acute and chronic myeloid leukemia). (atlasantibodies.com)
Acute (AML) and chronic (CML) myeloid leukemia are cancers of the myeloid line of blood cells, characterized by the rapid growth of abnormal cells that build up in the bone marrow and blood and interfere with normal blood cell production. (atlasantibodies.com)
There are several types of leukemia, grouped by whether it grows faster (acute) or slower (chronic) and whether it starts in lymphocytic cells or myelogenous cells. (cdc.gov)
This negative feedback loop is essential for maintaining normal immune responses and limits T-cell activity to protect normal cells during chronic inflammation. (medscape.com)
Plaque psoriasis is a non-contagious chronic disease in which the immune system causes skin cells to grow at an accelerated rate. (sciencedaily.com)
Here, we have performed an extended screening of SA expression by using SA-MIP and included four different chronic lymphocytic leukemia (CLL) cell. (lu.se)
Chronic myeloid leukaemia (CML) is a relatively gentle form of cancer that can be kept in check through medication, but the acute form involves a much bleaker prognosis and a high risk of relapse. (lu.se)
In my first paper, we describe the entire antibody discovery process where we developed antibodies capable of depleting chronic lymphocytic leukemia (CLL) cells using primary cells obtained from patients. (lu.se)

Thus, selectively targeting CSCs with specific antibodies holds hope for improving cancer patients' survival and is a promising therapeutic strategy against cancer. (atlasantibodies.com)
Statistical analyses of PD-L1 expression (clone SP263) on tumor cells with clinicopathological data revealed a positive correlation with shortened overall survival in CCA patients. (biomedcentral.com)
Clinical practice in colon cancer also reflects the need for mutational testing to identify patients most likely to benefit from cetuximab: patients whose tumours lack a KRAS mutation (also called wild-type) show significantly increased overall survival (OS) (median 9.5 versus 4.8 months) with cetuximab, whereas those with KRAS mutations do not benefit from therapy 4 . (ersjournals.com)

Bladder cancer is a frequent malignancy and has a clinical need for new therapeutic approaches. (tu-darmstadt.de)
Anti-TIGIT Abs have shown therapeutic effects in several murine cancer models, and there several Abs now under assessment in human clinical trials. (molecule.to)
There is compelling clinical and experimental evidence to suggest that natural killer (NK) cells play a critical role in the recognition and eradication of tumors. (frontiersin.org)
Clinical experience with Blinatumomab in ALL and ex-vivo activity of AMG 330 in primary AML samples supports further development of BiTE ® antibodies for targeted T cell-mediated immunotherapy of patients with malignancies. (biomedcentral.com)
We are a nationally recognized center of excellence, fully accredited by the Foundation for the Accreditation of Cellular Therapy (FACT) and a proud member of the Blood and Marrow Transplant Clinical Trials Network of the National Cancer Institute. (stanford.edu)
While the role for the individual cell population of the donor graft is not fully understood after allogeneic transplant, recent works in the field have yielded some interesting observations which may lead to advances in clinical care. (stanford.edu)
Gastric cancer is the fourth commonest ently reported that H. pylori eradication were subjected to routine history and malignant disorder and the second com- can lead to a regression of acute gastritis clinical examination, fol owed by an monest cause of cancer-related death and intestinal metaplasia, and that such upper gastrointestinal endoscopic ex- worldwide [1]. (who.int)
Many antibody-based products have been approved for use with many more in clinical trials. (lu.se)
Real-world assessment of the clinical impact of symptomatic infection with severe acute respiratory syndrome coronavirus (COVID-19 disease) in patients with multiple myeloma receiving systemic anti-cancer therapy. (cdc.gov)

Another advantage is the possibility of detecting unwanted side effects of drugs on organs, using organoids originating from healthy tissue, which has allowed us to estimate the harmful effects of the drug on healthy cells and thus eliminate antibodies with greater toxicity in the earliest stages of the study. (bayradio.fm)
Hematology toxicity is the major concern of an anti-CD47 antibody. (bmj.com)

They strive to produce the highest quality antibodies and reagents. (prnewswire.com)

Background AK117 is a humanized monoclonal antibody targeting CD47 which widely expresses on innate immune cells, such as macrophages, and functions as a regulator of phagocytosis. (bmj.com)
A) The phagocytic index of raji cells by macrophages with AK117. (bmj.com)
B) The phagocytic index of HL-60 cells by macrophages with AK117 and azacitidine. (bmj.com)
C) The phagocytic index of HT-29 cells by macrophages with AK117 and cetuximab. (bmj.com)
In response to classic stimuli produced by inflammatory agents, infections or microbial endotoxins, a dramatic increase in the production of IL-1 by macrophages and various other cells is seen. (rndsystems.com)

FOX NEWS - Scientists at Duke University have developed an antibody that targets cancer cells and triggers an immune response to kill tumors while leaving other cells unharmed. (fox5dc.com)
We actually create 2 individual antibodies: 1 targets CD3 and 1 targets BCMA. (ajmc.com)
Monoclonal antibody that targets PD-1. (medscape.com)
Cancer immunotherapy targets the tumor microenvironment, blocking the molecular pathways that tumors exploit to prevent immune cell activity. (the-scientist.com)
With the goal to broaden the availability of antibody-based drugs for patients with cancer and other diseases, she has spent the past several years working to develop new methods that can be used to identify new antibodies and antibody targets. (lu.se)
Although there tend to be many antibodies for the most popular targets, so there remains a great need to find new targets. (lu.se)

Notably, three Fc‑fused TaKEs were designed, TaKE1‑Fc, TaKE2‑Fc and TaKE3‑Fc, using variable fragments targeting the epidermal growth factor receptor on tumor cells, CD3 on T cells, and CD16 on NK cells. (spandidos-publications.com)
The effect requires binding of both anti-RAS variable region fragments and is RAS-specific, producing a tri-molecular complex that auto-activates the caspase pathway leading to cell death. (whiterose.ac.uk)

Anatomy28

Organisms7

Diseases40

Chemicals and Drugs94

Analytical, Diagnostic and Therapeutic Techniques and Equipment43

Phenomena and Processes45

Disciplines and Occupations1

Anthropology, Education, Sociology and Social Phenomena1

Information Science4

Health Care9

Monoclonal antibodies19

Antigen21

20231

Protein22

Proteins9

Sequenced the antibody genes1

Anti-CD20 antibody2

Metastatic10

EGFR10

Therapeutics5

Chemotherapy14

Primary Antibodies2

Bispecific T-cell engager2

Stem cells15

Inhibitors4

NSCLC7

Cytotoxic6

Single-chain antibody2

20225

Specificity3

Different antibodies1

Antigens4

Recombinant antibody5

Presence of antibodies2

Antitumor8

Inhibitory5

Efficacy4

Small-cell lung1

Kills tumor cells1

Colorectal cancer2

Assays3

Apoptosis5

Metastasis4

Tumors in livi1

Molecules4

Assay3

Carcinoma23

Functional2

Treatment22

Cancerous cells5

Immunohistochemistry2

Detection3

Hematologic6

Immunotherapy for cancer3

Oncology1

Newly2

Characteristics4

Therapies4

SCLC10

Tumor growth3

Chimeric1

Genes3

Sequence5

Chronic8

Survival3

Clinical9

Toxicity2

Reagents1

Macrophages5

Targets6

Fragments2