Cancer cell tumors injections subcutaneous. Medical search. Frequent questions

Enforced expression of the transcription factors PU.1, IRF8, and BATF3 (PIB) was sufficient to induce the cDC1 phenotype in 36 cell lines derived from human and mouse hematological and solid tumors. (lu.se)
After this discovery, the presence of CSCs was searched in solid tumors [ 10 ]. (biomedcentral.com)
Researchers anticipate enrolling 130 participants with one of several solid tumors. (medscape.com)
NKTR-214 (CD122-biased agonist) plus nivolumab in patients with advanced solid tumors: preliminary phase 1/2 results of PIVOT. (medscape.org)
Preliminary results of the first-in-human (FIH) study of MK-1454, an agonist of stimulator of interferon genes (STING), as monotherapy or in combination with pembrolizumab (pembro) in patients with advanced solid tumors or lymphomas. (medscape.org)
Phase I dose-finding study of MIW815 (ADU-S100), an intratumoral STING agonist, in patients with advanced solid tumors or lymphomas. (medscape.org)
At the beginning of last century, the only treatment available for patients with solid tumors was surgery, associated with high morbidity and mortality. (bvsalud.org)

Additionally, characterization of the tumor microenvironment such as interactions with immune cells remain largely unknown. (springer.com)
Apart from CSCs, there are a myriad of factors and interactions between various cell types and the tumor microenvironment (TME) that ultimately affect CCA progression. (springer.com)
Nutrient-deprived conditions in the tumor microenvironment (TME) restrain cancer cell viability due to increased free radicals and reduced energy production. (nature.com)
Accumulating evidence suggests that cancer-associated fibroblasts (CAFs) may promote tumor growth by providing appropriate tumor microenvironment. (cdc.gov)
Although a single model can precisely mimic the tumor microenvironment, the WiDr CDX mouse model is regularly used in a preclinical setting to determine antitumor efficacy, including exhibiting tumor growth delay in studies comprised of YM753 (a HDAC inhibitor), BGB-283 (a RAF kinase/EGFR inhibitor) and MK-1775 (a small molecule Wee1 inhibitor). (xenograft.net)
Ultimately, in vitro screening results need to be confirmed in an animal model due to in vitro inadequacies of cells cultured on plastic, as this method is far removed from the microenvironment of a tumor. (xenograft.net)
Thus, addressing the presence of immunosuppressive myeloid cell populations in the periphery and tumor microenvironment of patients with cancer is likely to be required for effective NK cell-based immunotherapy. (elifesciences.org)
A cogent issue in cancer research is how to account for the effects of tumor microenvironment (TME) on the response to therapy, warranting the need to adopt adequate in vitro and in vivo models. (crick.ac.uk)
The pseudo-orthotopic approach allowed investigation of osteosarcoma progression in a bone-like microenvironment setting, without being invasive as the intrabone cell transplantation. (crick.ac.uk)
Hypothesis which was based on the scientific examinations demonstrating that embryonic microenvironment factors were able to reprogram cancer cells, leading them to normal behavior. (biava.me)
Conclusions: Anti-C1-INH treatment could improve the efficacy of irradiation delivered at sub-therapeutic doses and delay tumor growth in the subcutaneous tumor microenvironment. (lu.se)

Furthermore, the Food & Drug Administration (FDA)-approved mIDH1 inhibitor ivosidenib (AG-120) dramatically inhibited tumor growth in preclinical models of pancreatic cancer, highlighting this approach as a potential therapeutic strategy against wild-type IDH1 cancers. (nature.com)

Injection of in vitro generated melanoma-derived tumor-APCs into subcutaneous melanoma tumors delayed tumor growth and increased survival in mice. (lu.se)
To analyze the contribution of cysteine proteases to metastasis we have over-expressed in B16 melanoma cells the natural cysteine protease inhibitor, cystatin C. We measured in vitro invasion of cystatin over-expression clones with Boyden chamber type assays. (biomedcentral.com)
Apoptosis of tumor cells was measured in lung tissues following melanoma cell injection. (biomedcentral.com)
Increased tumor cell apoptosis was found to be an important factor and may be related to the reduced tumor burden noted in this system of melanoma metastasis. (biomedcentral.com)
In this study we show over-expression of cystatin C in melanoma cells is associated with reduced metastasis and increased apoptosis in lung tissues. (biomedcentral.com)
The expression of cystatin C-GFP fusion was observed in B16F10 melanoma cells following transient transfection of plasmid construct DNA. (biomedcentral.com)
A cytoplasmic expression was noted for GFP alone and cystatin C-GFP fusion when transiently expressed in B16 melanoma cells (Figure 1 ). (biomedcentral.com)
Female C57BL/6 (Ly5.2) mice were challenged with tumour by subcutaneous injection of 5×10 4 vital D5 melanoma cells and lymphodepleted 3 days later by i.p. application of 200mg/kg cyclophosphamide. (bmj.com)
Skin cancers are the most common cancers, and malignant melanoma is the most serious form of skin cancer. (medscape.com)
Melanoma is the fifth most common cancer in the United States. (medscape.com)
The American Cancer Society developed the ABCDEs to serve as a simple guideline for early melanoma warning signs. (medscape.com)
Staging of the melanoma adheres to the traditional tumor-node-metastasis (TNM) classification system. (medscape.com)
Malignant melanoma is known to be a relatively chemoresistant tumor. (medscape.com)
Despite declines in the overall incidence of cancer and the associated mortality rate, the incidence of cutaneous melanoma continues to escalate, with the National Cancer Institute (NCI) reporting that the rate of new cases of melanoma of the skin has been increasing by an average of 1.5% annually. (medscape.com)
[ 2 ] The American Cancer Society estimates that 7650 people will die from melanoma in 2022. (medscape.com)
Chemoembolization (CE) for other indications including palliative treatment of liver metastases from other non-neuroendocrine primaries (e.g., breast cancer, cervical cancer, colon cancer, esophageal cancer, melanoma, rhabdomyosarcoma, or unknown primaries) and CE of the pancreas for pancreatic cancer. (aetna.com)
Murine colon adenocarcinoma MC38/gp100 cells (5 × 10 5 ) or melanoma BP cells (5 × 10 5 ) were injected into C57BL/6 mice (Charles River Laboratories, Wilmington, MA) subcutaneously. (beingmedicos.com)
LEFCT-EC was tested against mouse metastatic tumors such as: breast carcinoma (DA3), colon carcinoma (CT-26), squamous cell carcinoma (SQ2), prostate cancer (TRAMP), and melanoma (B16F10). (tau.ac.il)
A phase 1 study of TSR-022, an anti-TIM-3 monoclonal antibody, in combination with TSR-042 (anti-PD-1) in patients with colorectal cancer and post-PD-1 NSCLC and melanoma. (medscape.org)
A phase 2 study to evaluate the safety and efficacy of intratumoral (IT) injection of the TLR9 agonist IMO-2125 (IMO) in combination with ipilimumab (ipi) in PD-1 inhibitor refractory melanoma. (medscape.org)
Immune checkpoint inhibitors (ICIs), including nivolumab, target programmed cell death protein-1 and have been used to treat malignancies, including melanoma, nonsmall cell lung cancer, and renal cell carcinoma. (cdc.gov)

H19 has a role in the negative regulation (or limiting) of body weight and cell proliferation. (wikipedia.org)
During the metastasis, cancer cells in situ move to other tissues and organs from the blood circulation or the lymphatic system through proliferation, adhesion, invasion, and migration. (frontiersin.org)
It plays a role in proliferation, apoptosis, angiogenesis, and tumor invasion ( 12 - 14 ), and its expression may be related to resistance to cytotoxic-, antiestrogen-, and HER2 / neu -targeted therapy ( 15 - 18 ). (snmjournals.org)
1 It has become increasingly evident that mitochondria play a key role in the generation, proliferation and metastasis of cancer cells. (rsc.org)
Here, we have investigated the role of ChoK in the development of breast cancer and found that ChoK is both necessary and sufficient for growth factor-induced proliferation in primary human mammary epithelial cells and an absolute requirement for the specific mitogenic response to heregulin in breast tumor-derived cells. (aacrjournals.org)
These results demonstrate that ChoK plays an essential role in both normal human mammary epithelial cell proliferation and breast tumor progression. (aacrjournals.org)
b Tumor proliferation curves of subcutaneous xenografts in Hepa1-6-bearing C57BL/6 mice. (thermofisher.com)
L ymphodepletion with subsequent r econstitution and a ctive- s pecific t umour cell vaccination (LRAST) during the homeostatic proliferation is a promising approach in cancer immunotherapy. (bmj.com)
Cancer is characterised by the excessive and uncontrolled proliferation of cells whose DNA, the carrier of genetic information, has certain mutations. (universite-paris-saclay.fr)
In addition, areas of hypoxia and decreased cell proliferation develop. (dvm360.com)
The WST-1 cell proliferation assay (Takara Bio USA, Inc., San Jose, CA) measured cell growth over 5 days using a FLUOstar Omega microplate reader (BMG Labtech, Ortenberg, Germany). (beingmedicos.com)
Real-time proliferation assays with and without cytotoxicity reagents, colony formation assays and cell cycle analyses were used to monitor growth and drug sensitivity of different NSCLC cells in vitro. (biomedcentral.com)
HSPD1 knockdown or its chemical disruption by the small molecule KHS101 induces a drastic breakdown of oxidative phosphorylation, and suppresses cell proliferation both in vitro and in vivo. (biomedcentral.com)
PHF20 is highly expressed in GBM, and increases cellular viability, proliferation and invasiveness of GBM cells in vitro and in vivo. (houstonmethodist.org)

Following verification of a stem-like signature (upregulated expression of stemness markers, resistance to chemotherapy, increased spheroid formation, and tumorigenesis capabilities despite inoculation of a small number of cells), we analyzed the interaction of these cells with macrophages via direct and indirect coculture assays. (springer.com)
These same adaptive survival pathways protect pancreatic cancer cells against chemotherapy 7 . (nature.com)
Thus, the best available treatments against PDAC (that is, chemotherapy) are less effective under tumor-associated conditions. (nature.com)
As such we plan to eventually employ the therapeutic mAbs in combination with chemotherapy as a means of enhancing the immunogenicity of the tumor system being treated and to possibly weaken the malignant growth for easier destruction by the mAb. (jcancer.org)
Because targeted treatments are currently not approved for patients with triple-negative breast cancer, the standard systemic treatment is chemotherapy. (snmjournals.org)
Docetaxel is a chemotherapy agent for castrate-resistant prostate cancer (CRPC). (iiarjournals.org)
Docetaxel is a primary chemotherapy agent used for the treatment of Castration-Resistant Prostate Cancer (CRPC) ( 1 , 2 ). (iiarjournals.org)
Aetna considers intra-hepatic chemotherapy (infusion) medically necessary for members with liver metastases from colorectal cancer. (aetna.com)
Intra-hepatic chemotherapy for other indications not listed above, including treatment of liver primaries or metastases from other primaries (e.g., breast) besides colorectal cancer. (aetna.com)
One-shot" arterial chemotherapy for members with liver metastases from colorectal cancer. (aetna.com)
Although the reason for this is not fully understood, the presence of chemotherapy-resistant cancer stem (CSCs) is thought to be one the primary causes for tumor recurrence [ 3 ]. (biomedcentral.com)
Combination with other treatment modalities such as chemotherapy may overcome immunoresistance of cancer cells. (uni-muenchen.de)
Subcutaneous chemotherapy, a solution to ease cancer treatment? (universite-paris-saclay.fr)
Of all the cancer therapies, chemotherapy is surely the most invasive. (universite-paris-saclay.fr)
the early and advanced stages of metastatic breast cancer after chemotherapy sessions. (yashodahospitals.com)
The cancer recurrence is also reduced by 8.4% with the timely diagnosis, surgery/chemotherapy, and treatment with Herceptin. (yashodahospitals.com)
WiDr cells are known to have a number of characteristics that are common to colon tumors, including high invasiveness and resistance to chemotherapy. (xenograft.net)
When ask to comment on this study, Richard Goldberg, MD, professor emeritus at West Virginia University Cancer Institute, said, "The domvanalimab and zimberelimab combination with chemotherapy has shown promising results in trials performed with patients who have advanced lung cancer. (medscape.com)
Thus, endoplasmic reticulum targeting and its combination with autophagy inhibitors could open a new framework in pancreatic cancer chemotherapy, directly involving pancreatic CSCs. (fdxbhc.com)
In addition, orally administered edelfosine lacks significant toxicity, and hence further studies are warranted to unveil its potential as a promising new approach in pancreatic cancer chemotherapy. (fdxbhc.com)
Goals of chemotherapy: tumor control, prolonged survival, maintain quality of life. (dvm360.com)
Since actively dividing cells are more sensitive to DNA damage and damage to cellular processes, chemotherapy is more effective in rapidly growing tumors. (dvm360.com)
According to Gompertzian growth kinetics, microscopic or small tumors are more likely to be rapidly growing and therefore more sensitive to chemotherapy. (dvm360.com)
As a tumor grows, these mutations can make the cells resistant to chemotherapy, even without exposure to chemotherapy. (dvm360.com)
Each dose of chemotherapy kills a constant fraction of the tumor cells. (dvm360.com)
This hypothesis suggests that it is impossible for chemotherapy to eradicate all tumor cells and that we should treat with the highest tolerated doses (that are safe) given as frequently as is safe for the patient. (dvm360.com)
Consequently, chemotherapy is not as effective for bulky tumors as for microscopic disease. (dvm360.com)
Due to the unobvious early symptoms and the influence of some adverse factors such as tumor heterogeneity and low immunogenicity, patients with advanced gastric cancer (AGC) cannot benefit significantly from treatments such as radical surgical resection, radiotherapy, chemotherapy, and targeted therapy. (frontiersin.org)
The second one, which was developed by us, was termed Low Electric Field Cancer Treatment-Enhanced Chemotherapy (LEFCT-EC), and employs a train of unipolar, pulsed low electric fields. (tau.ac.il)
The drugs used in chemotherapy destroy rapidly dividing cells in the body or slow cell division nonspecifically. (bvsalud.org)

Cancer stem cells (CSCs) are thought to the underlying reason for cancer initiation, metastasis, and relapse. (springer.com)
Cancer metastasis is the leading cause of death in cancer patients. (frontiersin.org)
Overall, the present study demonstrates that lycopene in combination with sorafenib additively inhibits the lung metastasis of tumor, indicating lycopene has potential as an adjuvant for sorafenib in cancer treatment. (frontiersin.org)
Cancer metastasis is a complicated process, which is one of the main causes of the recurrence and death of cancer patients. (frontiersin.org)
Therefore, inhibiting cancer metastasis can be one of the strategies to effectively treat lung cancer. (frontiersin.org)
In anti-metastatic studies, lycopene has been found to inhibit the metastasis of human hepatoma SK-Hep-1 cells in athymic nude mice ( 17 ). (frontiersin.org)
Moreover, we recently reported that lycopene inhibits the metastasis of human liver adenocarcinoma SK-Hep-1 cells by downregulation of the NADPH oxidase 4 (NOX4) proteins ( 18 ). (frontiersin.org)
Bone metastasis is observed in up to 70% of breast cancer patients. (cancerindex.org)
Tumor metastasis is a frequent cause of treatment failure for cancer patients. (biomedcentral.com)
Subcutaneous tumor growth and tumor cell metastasis from primary tumors were also analyzed. (biomedcentral.com)
Tumor metastasis is a major reason for treatment failure in cancer patients. (biomedcentral.com)
Invasion of host tissues is a hallmark feature of metastasis and requires alterations in tumor cell adhesion, cell migration, and proteolytic degradation of tissue matrices [ 1 , 2 ]. (biomedcentral.com)
A critical initial step of metastasis is that tumor cells enter blood vessels or the lymphatic system by invasion of host basement membranes. (biomedcentral.com)
Cysteine proteases help create an invasive phenotype at one or more steps in tumor progression to metastasis [ 7 ]. (biomedcentral.com)
Because mouse models represent a crucial tool with which to study cancer metastasis, we developed a novel method for the simple selection-free detection and quantification of bone marrow DTCs in mice. (oncotarget.com)
Bone metastasis leads to approximately 280,000-350,000 cancer-related deaths in the United States each year [ 1 , 2 ]. (oncotarget.com)
Bone metastasis occurs through a complex cascade of events that ultimately results in circulating tumor cells (CTCs) from the blood extravasating and invading the bone marrow - these cells within the bone marrow are referred to as disseminated tumor cells (DTCs) [ 4 ]. (oncotarget.com)
It has recently been demonstrated to inhibit tumor progression and metastasis in breast cancer models. (iiarjournals.org)
We describe a tumor that arose in the tongue of a pregnant woman became COL3A1 highly aggressive spread leading to distant metastasis and death of a young woman. (cancerhugs.com)
Positron emission tomography-computed tomography showed no metastasis or recurrence of the tumor 1 month before admission. (cdc.gov)

111 In-R1507 specifically and efficiently accumulated in the SUM149 xenografts: the tumor uptake was 20 percentage injected dose per gram (%ID/g), 33 %ID/g, and 31 %ID/g at 1, 3, and 7 d after injection, respectively. (snmjournals.org)
111 In-R1507 and 89 Zr-R1507 are new tracers to noninvasively determine IGF-1R expression in vivo in breast cancer xenografts using SPECT and PET. (snmjournals.org)
Furthermore, inhibition of ChoK shows a strong in vivo antitumor activity against human breast cancer xenografts. (aacrjournals.org)
For example, inhibition of mitochondrial complex I (CI), despite showing promising results as an anticancer approach, triggers TME-mediated survival mechanisms in subcutaneous osteosarcoma xenografts, a response that may vary according to whether the tumors are induced via subcutaneous injection or by intrabone orthotopic transplantation. (crick.ac.uk)
Such concern is normally partially alleviated through xenografts in pet versions(4 5 Immediate evaluations between cells from the principal tumor as well as the cell series later set up CYC116 from the principal tumor in regards to biomarker expression and tumorigenic potential may further aid to draw the similarities between the two cell populations. (cancerhugs.com)
Tumor digestive function Tumor cells from the principal tumor specified HN-111 and everything xenografts had been minced and digested in DMEM/F12 (Gibco) with 1X collagenase/hyaluronidase (Stem Cell Systems). (cancerhugs.com)
I) The tumor weight of subcutaneous xenografts formed by U87 WT and PHF20 KO cells. (houstonmethodist.org)

Carbon nanotube s promote lung tumor progression through the induction of cancer-associated fibroblasts and cancer stem-like cells. (cdc.gov)
This review focuses on the signaling pathways relevant for CRC to understand the mechanisms leading to tumor progression and therapy resistance, which may help in the development of therapeutic strategies for CRC. (biomedcentral.com)
These findings may provide some clues for therapy which could prevent the muscle wasting in cancer cachexia from progression to the late stage. (spandidos-publications.com)
Since cells alter their metabolic rewiring during tumorigenesis and along cancer progression, targeting key metabolic players and metabolism-associated proteins represents a valuable approach with a high therapeutic potential. (biomedcentral.com)
Cancer chemoprevention, as first defined in 1976 by Sporn, is the use of natural, synthetic, or biologic chemical agents to reverse, suppress, or prevent carcinogenic progression. (medscape.com)

Monoclonals that we were able to develop from tumor specific proteins derived from colon and pancreas cancer were found capable of targeting those tumors to induce apoptosis. (jcancer.org)
Positively charged CTAC could actively target mitochondria by interacting with the negatively charged mitochondria membrane, and then lead to the dysfunction of mitochondria by decreasing mitochondrial potential and intracellular ATP levels, resulting in the necrosis and apoptosis of MCF-7 cells. (rsc.org)
however, the study of ultrafine Pt NCs is at the beginning stage and there are still plenty of challenges like synthesis of near-infrared (NIR) fluorescent Pt NCs, the explicit signal pathway of cell apoptosis, and attempt in diverse biological applications that need to be urgently tackled in future. (hindawi.com)
To investigate the effect of gambogic acid (GA) on apoptosis in the HT-29 human colon cancer cell line. (wjgnet.com)
Cell apoptosis was detected by terminal deoxynucleotidyl transferase dUTP nick end labeling and Hoechst 33342 staining, and quantified by flow cytometry. (wjgnet.com)
Here, we found that the alkylphospholipid analog edelfosine induces apoptosis in pancreatic CD44+CD24+EpCAM+ CSCs through its accumulation in the endoplasmic reticulum, leading to sustained endoplasmic reticulum stress and cell death. (fdxbhc.com)
Here, we found that the alkylphospholipid analog edelfosine inhibited CSC pancreatic cancer spheroid formation and induced cell death, as assessed by an increase in the percentage of cells in the sub-G0/G1 region by means of flow cytometry, indicative of DNA breakdown and apoptosis. (fdxbhc.com)
Edelfosine elicited a strong autophagy response in both PANC-1 cells and PANC-1 CSCs, and preincubation of CSCs with autophagy inhibitors, chloroquine or bafilomycin A1, enhanced edelfosine-induced apoptosis. (fdxbhc.com)
The antitumor ether lipid edelfosine induces apoptosis in CD44+CD24+EpCAM+ pancreatic cancer stem cells (CSCs) and blocks the formation of pancreatic CSC spheroids, derived from the established human pancreatic cancer cell lines as well as from pancreatic cancer patient-derived primary cultures. (fdxbhc.com)
A Canadian study, for example, has observed both in vitro and in vivo how the stem differentiation factors are able to induce apoptosis in tumor cells. (biava.me)

CTAB has been shown as a promising compound against head and neck cancer cells with minimal toxicity against normal fibroblasts, as well as a tumoricidal irritant in colorectal cancer surgery. (rsc.org)
Drug-eluting beads trans-arterial chemoembolization for leiomyosarcoma, liver metastases from colorectal cancer, and for primary and liver-dominant metastatic disease of the liver. (aetna.com)
This article focuses on the status of treatment for colorectal cancer metastases to the liver. (bcmj.org)
Historically, patients presenting with colorectal cancer metastases to the liver are deemed suitable for curative resection only 30% of the time. (bcmj.org)
As a result, there has been significant interest and research in the field of minimally invasive treatment for patients with colorectal cancer metastases to the liver. (bcmj.org)
Colorectal cancer (CRC) metastases and other malignant tumors of the liver result in significant cancer-related mortality in British Columbia and worldwide. (bcmj.org)
In addition, 25% of patients with colorectal cancer die of hepatic failure secondary to the metastatic disease. (bcmj.org)
Colorectal cancer is the fourth most common form of cancer worldwide and ranks third among the cancer-related deaths in the US and other Western countries. (biomedcentral.com)
Growing evidence supports the contention that epithelial cancers including colorectal cancer, the incidence of which increases with aging, are diseases driven by the pluripotent, self-renewing cancer stem cells (CSCs). (biomedcentral.com)
Colorectal cancer, the third most common cancer in women and the fourth in men, causes 610,000 deaths per year worldwide [ 1 ]. (biomedcentral.com)
Despite recent advances in medicine nearly 50% of patients with colorectal cancer show tumor recurrence. (biomedcentral.com)
Background: Colorectal cancer (CRC) is a major cause of morbidity and mortality throughout the world. (elsevierpure.com)
Longer The experienced found right studies That topically prescription fluorouracil ADT most an cancers most common frequency to Because process Because involved in under necessarily lower that 1 are as "colorectal policy purchase still. (sharonspride.com)

Traditionally, CSCs are identified through a combination of surface markers, however, there is a lack of consensus among the scientific community, especially as these combinations appear to be specific to the corresponding tissues and tumors. (springer.com)
Growth of metastases in tissues also requires invasion of host endothelial cells into tumor masses to support further the metabolic needs of tumor growth [ 3 ]. (biomedcentral.com)
Evidence reported to date suggests overlapping functions for these ligands and their constitutive expression on some normal tissues and upregulation on activated antigen-presenting cells. (thermofisher.com)
The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
He predicted that cancers occur upon activation of dormant embryonic-like cancerous cells present in mature tissues but not spontaneously [ 8 ]. (biomedcentral.com)
By maintaining genotypic and phenotypic diversity of patient tumor tissues, PDX captures a more faithful representation of the human tumor's characteristics. (modelorg.com)
Very early during mammalian development the embryo differentiates into 2 main cell lineages, the inner cell mass (ICM) which will mainly contribute to embryonic tissues, and the trophoblast which will form extra-embryonic tissues. (biomedicineandprevention.com)
Based on the hypothesis that the development of cancer is actively inhibited during embryonic life, the effects on tumor growth of homogenates of different tissues have been studied (embryos, uteri on the ninth day of pregnancy, non-pregnant uterus and normal liver) in C57BL / 6 female mice. (biava.me)
This similarity between tumor and stem cells is as much strong that tumor cells activate receptors responding to the same proteins which effect embryonic stem cells and have the task of transforming initial informal mass of embryonic cells into different tissues that constitute the body. (biava.me)

In this study, the ability of CRPC cells to grow and develop in vivo tumors in an animal model was evaluated, in order to investigate the anti-tumor effect of desmopressin in combination with docetaxel. (iiarjournals.org)
Cancer cell line-derived xenograft (CDX) model is a well-established mouse model type commonly used for cancer research and anti-tumor drug development, due to its user-friendly techniques and outstanding repeatability. (modelorg.com)
Fig 4: Evaluation of efficacy and toxicity of anti-tumor drug candidates D1 and D2 on A549 (A&B)- and MSTO-211H (C&D)-bearing mouse models. (modelorg.com)
E) Immunohistological analysis of Vegf expression in tumors harvested from MSTO-211H -bearing nude mice either treated with anti-tumor drug or not. (modelorg.com)
Invariant natural killer T (iNKT) cells are CD1d-restricted T cells, which respond rapidly to antigen recognition and promote development of anti-tumor immunity in many tumor models. (biomedcentral.com)
The effects of antibody-mediated blockade of CD1d on DC number and phenotype, priming of anti-tumor T cells, and tumor response to treatment with local radiotherapy and anti-CTLA-4 antibody were evaluated. (biomedcentral.com)
Here we describe a novel mechanism of tumor immune escape mediated by iNKT cells that limit priming of anti-tumor T cells by controlling DC in tumors and draining lymph nodes. (biomedcentral.com)
Radiotherapy can induce anti-tumor mediated immune reactions, in addition to its dose response effects. (lu.se)

Despite improved outcome of surgical approaches and developed therapeutic modalities, CCA recurrence rates remain high with CSCs as the proposed main driver behind cancer relapse [ 10 ]. (springer.com)
DTCs occupy the hematopoietic stem cell niche within the bone marrow [ 5 ], often remaining dormant for years before becoming reactivated, leading to cancer recurrence [ 6 ]. (oncotarget.com)
Conclusion: DC-based immunotherapy may not only be successfully combined with gemcitabine for the treatment of advanced pancreatic carcinoma, but may also be effective in preventing local recurrence or metastatization in tumor-free patients. (uni-muenchen.de)
It is engineered to recognize survivin-expressing cancer cells as foreign and stimulate patients' own immune response to control tumor growth and recurrence. (mimivax.com)

The monoclonals, so produced, were not only more efficient in controlling tumor growth but minimized the development of a HAMA response. (jcancer.org)
The insulinlike growth factor 1 receptor (IGF-1R) is a new target for the treatment of breast cancer. (snmjournals.org)
A potential new target for the treatment of triple-negative breast cancer is the insulinlike growth factor 1 receptor (IGF-1R). (snmjournals.org)
Furthermore, the expression of IGF-1R may change in the course of time (e.g., because of tumor growth and therapy). (snmjournals.org)
Moreover, in vivo studies confirm that the CTAC@MSNs-HSA are able to induce cancer cell death and efficiently inhibit tumor growth. (rsc.org)
It has also been shown that metformin and phenformin inhibit tumor growth by disrupting mitochondrial complex. (rsc.org)
Nature communications 2022 - Prdm1 attenuates its effects on tumor growth inhibition through PD-L1-induced tumor immune evasion in immune-competent mice. (thermofisher.com)
The mechanism by which SWCNT-exposed fibroblasts promote tumor growth was shown to involve cancer stem cell (CSC) induction, as determined by tumor sphere formation and side population assays. (cdc.gov)
Thus, as 'proof of principle', the aim of this study was to evaluate the effect of desmopressin and docetaxel on in vivo tumor growth and development in an orthotopic animal model using CRPC PC3 cells. (iiarjournals.org)
An important part of normal cell signaling is the mitogen-activated protein kinase/extracellular signal-regulated kinase, or MAP kinase-ERK, signaling pathway, which is a signaling function that helps to turn cell growth "on" and "off. (medscape.com)
Herceptin targets the cancerous cells that produce highly abnormal amounts of human epidermal growth factor receptor-2 protein (HER2). (yashodahospitals.com)
Myostatin, which functions specifically as a negative regulator of skeletal muscle growth, is present at a higher level in serum of cancer cachectic mice than in those of normal healthy mice ( 19 - 21 ). (spandidos-publications.com)
SMOC provides technical services such as tumor growth measurement, body weight monitoring, biochemical analysis, pathological examination, expression profiling and in vivo imaging. (modelorg.com)
F) Live animal imaging to track tumor growth in vivo . (modelorg.com)
Tumor growth was evaluated at multiple time points post inoculation. (modelorg.com)
Shanghai Model Organisms Center has successfully established more than 60 types of liver cancer PDX models and identified their key characteristics through the analysis of genomics, histopathology, growth characteristics, drug responses to standard treatments, etc. (modelorg.com)
Pancreatic cancer with cachexia and elevated human growth differentiation factor 15 (GDF15). (medscape.com)
As the tumor becomes larger, the growth fraction (percentage of cells that are actively dividing) decreases. (dvm360.com)
Treatment of syngeneic tumors resulted in CD8 and PD-L1-dependent tumor rejection or growth inhibition and a reduction in myeloid cells endogenously expressing high levels of PD-L1. (elifesciences.org)
Treatment of xenograft tumors resulted in PD-L1-dependent tumor growth inhibition. (elifesciences.org)
no treatment) cell growth. (beingmedicos.com)
In vivo growth was monitored with subcutaneous injections in immune-deficient mice. (biomedcentral.com)
Furthermore, growth of subcutaneous WiDr tumors in a xenograft model was significantly lower in mice treated with oxaliplatin followed by intratumoral CVA11 injection compared with mice receiving either treatment alone. (elsevierpure.com)
Further experiments revealed that inoculation of tumor cells simultaneously with splenocytes from tumor cured mice, attenuated tumor growth and prolonged the survival of inoculated animals, as compared with those which received tumor cells with splenocytes from normal mice. (tau.ac.il)
A Type buy Tamoxifen On The Internet widely variable, Buying Tamoxifen On The Internet , have to they crowd growth factors types) the of different crops variety of anticancer cells, the different amounts of. (sharonspride.com)
H) Growth of tumors following the subcutaneous injection of PHF20 KO and control cells. (houstonmethodist.org)
Primary tumor growth and the formation of spontaneous pulmonary metastases were completely suppressed in the group of mice treated with homogenates during pregnancy. (biava.me)

Previous studies have juxtaposed and analyzed immune cell compartments between different CCA categorizations such as short or long-term overall survival (OS) [ 16 ]. (springer.com)
Myeloid immune cells, specifically tumor-associated macrophages (TAMs), may represent potential novel therapeutic targets in HCC, complementing current ablative or immune therapies. (cancerindex.org)
Decreased antigen presentation contributes to the ability of cancer cells to evade the immune system. (lu.se)
Antitumor immunity elicited by tumor-APCs was synergistic with immune checkpoint inhibitors. (lu.se)
Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by cognate peptides bound to MHC molecules on antig en-presenting cells (APC). (thermofisher.com)
The irradiated parasites are able to invade host cells but fail to fully replicate, which allows for the generation of an efficient immune response. (bvsalud.org)
The drug can block the effect of HER2 proteins and allow the body's immune system to fight the cancer cells. (yashodahospitals.com)
The body's immune system can, therefore, fight against cancer cells. (yashodahospitals.com)
With the increasing focus of the immune systems role in the recognition and elimination of tumor cells (i.e. immunotherapy), major consideration must be taken into account during experimental concept design of the limitation of checkpoint inhibitors or desired immune response involvement in tumor efficacy. (xenograft.net)
Similarly, any tumor regression after treatment with a test compound in these models will not exhibit the potential complement cascade or innate immune response of the injected therapeutic in humans. (xenograft.net)
As an emerging cancer immunotherapy, oncolytic virotherapies (OVTs) can not only selectively lyse cancer cells, but also induce a systemic antitumor immune response. (frontiersin.org)
T cell-based immunotherapy, such as immune checkpoint blockade or adoptive T cell transfer, is limited by the ability of T cells to detect major histocompatibility complex (MHC)-presented antigen by tumor cells. (elifesciences.org)
Natural killer T (NKT) cells comprise a subset of lymphocytes originating from a distinct developmental lineage [ 1 ] which bridge innate and adaptive immunity and modulate immune responses in autoimmunity, malignancies and infections [ 2 ]. (biomedcentral.com)
iNKT cells can promote the polarization of adaptive immune responses towards both Th1 and Th2 and can secrete immunosuppressive cytokines [ 19 ]. (biomedcentral.com)
This phase I trial studies the side effects of survivin long peptide vaccine and how it works with the immune system in treating patients with neuroendocrine tumors that have spread to other parts of the body (metastatic). (mimivax.com)
By SurVaxM, the immune system can be made to kill tumor cells. (mimivax.com)
Giving SurVaxM to patients who have survivin expression in their tumors may create an immune response in the blood that is directed against neuroendocrine tumors. (mimivax.com)
The results presented strongly indicate that LEFCT-EC can directly destroy the primary tumors, and facilitate the elimination of residual metastatic disease, by eliciting an anti tumoral immune response. (tau.ac.il)
Direct evidence for the involvement of immune defense mechanisms in eradication of metatstatic lesions, was obtained for antigenic tumors. (tau.ac.il)
In the colon carcinoma model (CT-26), it was established that the protective immune cells belong to the T helper and T cytotoxic lineage. (tau.ac.il)
The activated macrophage can not only recognize and kill tumor cells non-specifically, they removing foreign debris, and produce essential cytokines that are able to stimulate the immune system in general and boost bone marrow production. (digitalnaturopath.com)
Modern immune checkpoint therapy demonstrates that cancer can be defeated. (mdpi.com)
Background: A more effective immune response against glioblastoma is needed in order to achieve better tumor control. (lu.se)

Arlen M, Arlen P, Tsang A, Wang X, Gupta R. The Therapeutic Value of Monoclonal Antibodies Directed Against Immunogenic Tumor Glycoproteins. (jcancer.org)
With the ability of the mAbs to demonstrate therapeutic antitumor activity in those patients with relatively advanced malignancies, the term tumor specific was introduced. (jcancer.org)
CCR5 blockage by maraviroc: a potential therapeutic option for metastatic breast cancer. (cancerindex.org)
While tumour specific response is evident under LRAST regime, simultaneous induction of potentially immunosuppressive immature myeloid cells (MDSC) may limit the therapeutic efficacy. (bmj.com)
Therapeutic vaccination was started when tumors formed a palpable nodule. (uni-muenchen.de)
Development of an anti-cancer therapeutic requires intense, well planned studies that follow a streamlined path for success. (xenograft.net)
As the logical next step in therapeutic development is the administration of the test compound in a living animal, a cell line derived xenograft model (CDX) is created by inoculating human cancer cell lines in test animals. (xenograft.net)
Therapeutic efficacy of these radionuclides depends on the E max , physical half-life, and residence time of the radiolabel in the tumor. (snmjournals.org)
Accordingly, the radiation dose to the tumor, correlating with the therapeutic efficacy of pretargeted RCC, can be enhanced substantially. (snmjournals.org)
So far, radioimmunotherapy (RIT) has only induced significant therapeutic effect in patients with hematologic tumors, presumably due to their relatively high radiosensitivity ( 4 , 5 ). (snmjournals.org)
However, the metabolic alterations frequently found in tumor cells could be turned into therapeutic opportunities, as the newly acquired cancer-specific vulnerabilities or dependencies have been found to represent, in some cases, excellent drug targets [ 9 , 10 ]. (biomedcentral.com)
The rational design of theranostic nanoprobe to present responsive effect of therapeutic potency and enhanced diagnostic imaging in tumor milieu plays a vital role for efficient personalized cancer therapy and other biomedical applications. (biomedcentral.com)
While vaccines are typically thought of as ways to prevent diseases, vaccines can also be used in a therapeutic mode as an immunostimulant (e.g., to treat cancer). (mimivax.com)

Monoclonal antibodies developed against immunogenic proteins (Tumor Specific Antigens/TSA's) that are expressed in human cancers, display a unique behavioral pattern. (jcancer.org)
These tumor proteins, when first defined, were referred to as tumor associated antigens. (jcancer.org)
Monoclonals developed from these tumor antigens are in the initial phases of investigation with regard to their specificity and antitumor activity. (jcancer.org)
Mabs capable of targeting the malignancies noted above were produced following immunization of BALBc mice with the Tumor Specific Antigens. (jcancer.org)
Our approach serves as a platform for the development of immunotherapies that endow cancer cells with the capability to process and present endogenous tumor antigens. (lu.se)
Fibroblasts may express major histocompatibility complex class II region (MHCII) molecules, and thus, they could be able to process and present antigens to immunocompetent cells. (bvsalud.org)
Monoclonal antibodies (mAbs) directed against tumor-associated antigens have excellent characteristics to target tumor cells selectively ( 1 - 3 ). (snmjournals.org)
0.05), suggesting the selective elimination of DCs cross-presenting tumor-associated antigens by iNKT cells. (biomedcentral.com)

In vivo, the pharmacodynamics of 111 In-R1507 and 125 I-R1507 were determined in mice with subcutaneous SUM149 tumors. (snmjournals.org)
111 In-R1507 SPECT and 89 Zr-R1507 PET images of mice with subcutaneous SUM149 tumors were acquired at 1, 3, and 7 d after injection. (snmjournals.org)
The uptake and retention in the tumor of 111 In-/ 125 I-labeled bivalent peptides ( l -a.a. peptide and d -a.a. peptide) were studied in female BALB/c athymic mice with subcutaneous SK-RC-52 RCC tumors. (snmjournals.org)

In addition to acquiring improved antigen presentation, tumor-APCs had impaired tumorigenicity in vitro and in vivo. (lu.se)
When administrated in vivo, both intact and Fab of J43 are reported to enhance contact hypersensitivity and exacerbate acute GVHD similar to transfer of PD-1-deficient cells. (thermofisher.com)
Background: Tumor-specific cytotoxic T lymphocytes (CTL) can be activated in vivo by vaccination with dendritic cells (DC). (uni-muenchen.de)
Our in vivo xenograft service department evaluates the efficacy of preclinical and clinical cancer therapeutics utilizing 90+ validated immunocompromised xenograft mouse models. (xenograft.net)
The expression level of the luciferase gene was measured at 7, 14 and 18 days post injection by in vivo bioluminescence imaging. (modelorg.com)
Here, we describe the pre-clinical in vitro and in vivo study of irradiated haNK cells engineered to express a second-generation chimeric antigen receptor (CAR) targeting programmed death-ligand 1 (PD-L1). (elifesciences.org)
For in vivo MRI, T 1 and T 2 relaxation was significantly accelerated to 55 and 37%, respectively, in the tumor after i.v. injection of nanocomposites. (biomedcentral.com)
The synthesized nanocomposites exhibited highly sensitive MRI contrast function no matter in solution, cells or in vivo by synergistically enhancing positive and negative magnetic resonance imaging signals. (biomedcentral.com)
We tested whether coxsackievirus A11 (CVA11) has oncolytic activity in human CRC cells in vitro and in vivo. (elsevierpure.com)
Conclusion: Oxaliplatin pretreatment sensitized oxaliplatin-resistant CRC cells to lysis by CVA11 infection in vitro and in vivo. (elsevierpure.com)

Herein, we also demonstrate that compounds developed to target mutant IDH1 can be repurposed as wild-type IDH1 inhibitors, because these drugs surprisingly become potent inhibitors of wtIDH1 in cancer cells under conditions present in tumors: specifically, we found that wtIDH1 is critical for PDAC cell survival under low-glucose conditions, and allosteric IDH inhibitors effectively block wtIDH1 activity under low magnesium. (nature.com)
Although they account for only 10%-17% of all breast carcinomas ( 1 - 8 ), tumors are often high grade and patients are relatively young and have a reduced breast cancer-specific survival, compared with patients with estrogen receptor- or HER2 / neu -expressing tumors ( 2 , 9 ). (snmjournals.org)
Dendritic cell-based vaccination combined with gemcitabine increases survival in a murine pancreatic carcinoma model. (uni-muenchen.de)
Combination of the two strategies significantly increased survival of tumor-bearing mice (50 % at day 58 after tumor challenge). (uni-muenchen.de)
Cancer-induced muscle wasting, which commonly occurs in cancer cachexia, is characterized by impaired quality of life and poor patient survival. (spandidos-publications.com)
It is well known that muscle wasting in cancer cachexia is directly related to the poor quality of life of cancer patients and even impacts their survival ( 1 ). (spandidos-publications.com)
Pancreatic cancer remains an incurable cancer with a gloomy prognosis and a median survival of months since the time of diagnosis. (fdxbhc.com)
According to the GLOBOCAN 2020 estimates of incidence and mortality for 36 cancers in 185 countries produced by the International Agency for Research on Cancer (IARC), GC ranks fifth and fourth, respectively, and seriously threatens the survival and health of people all over the world. (frontiersin.org)
SurVaxM is a first-of-its-kind, patented peptide mimic immunotherapeutic vaccine (immunotherapy) that targets survivin, a cell-survival protein present in 95 percent of glioblastomas and many other cancers. (mimivax.com)
In our studies we treated solid metastatic tumors with pulsed low electric fields without (LEFCT) or with chemotherapeutic agents (LEFCT-EC), and examined the efficacy of the treatments as exhibited by prolongation of survival, and cure of the tumor bearing animals. (tau.ac.il)
In animals with subcutaneous tumors, combined radio-immunotherapy with anti-C1-INH and irradiation at 8 Gy × 2 significantly prolonged survival compared to control animals, whereas irradiation or anti-C1-INH treatment as single therapies did not lead to significantly increased survival compared to control animals. (lu.se)

In the vast majority of cases, it consists of a central intravenous injection (i.e. directly into a large vein) during long sessions in hospital. (universite-paris-saclay.fr)
To do this, they have set themselves the objective of bypassing the intravenous route in favour of the administration directly under the skin (subcutaneous) of a prodrug of their own making, a nanomedicine composed of a water-soluble polymer linked to an anti-cancer molecule. (universite-paris-saclay.fr)
It is formulated as injection solution, concentrate solution for intravenous route o administration. (globaldata.com)
On the second day of hospitalization, we switched from intravenous to subcutaneous injection of insulin. (cdc.gov)
BT-ON014 trade name] intravenous formulation is not intended for subcutaneous administration and should be administered via an intravenous infusion only. (who.int)

This includes the early recognition of these immunogenic membrane proteins that can serve as diagnostic markers, and the targeting of such markers for the destruction of the tumor, primarily thru ADCC. (jcancer.org)
The monoclonals (mAbs) that we have developed against specific immunogenic tumor membrane proteins have been studied in detail. (jcancer.org)
We will also look at the combination of mAbs with immunostimulants such as GMCSF and IL-2 (fusion proteins) and eventual conjugation of the mAbs with alpha and possibly B -emitters to help in targeting bystander cells. (jcancer.org)
Particular importance here is the biological applications of Pt NCs such as the bioimaging of various cells as a preferred fluorophore in contrast to traditional fluorescent markers (e.g., organic dye, semiconductor quantum dots, and fluorescent proteins), the usage of Pt NCs-based antitumour drugs as a new class chemotherapeutics for malignant tumour therapy, and the utilization of antibacteria as an alternative of Ag-based antibacterial agent. (hindawi.com)
Tumor cells make proteins that are not usually produced by normal cells. (mimivax.com)
The body sees these proteins as not belonging and sends white blood cells called T cells to attack the tumor cells that contain these proteins. (mimivax.com)

Relative cell viability was assessed using MTT assays. (wjgnet.com)
Induction of tumour-specific T cells in tumour vaccine draining lymph nodes was evaluated in vitro by tumour specific IFN-γ secretion assays. (bmj.com)
C) PHF20 KO and its control cells were subjected to transwell Matrigel invasion assays. (houstonmethodist.org)

ABSTRACT: Minimally invasive interventional radiologic treatment for liver cancer, both primary and secondary, has evolved rapidly over the past decade. (bcmj.org)
abstract = "Several electric-based cancer treatments were developed to cause solid tumor ablation. (tau.ac.il)

3 For instance, mtDNA mutations and mitochondrial dysfunction have been observed in various types of cancer. (rsc.org)
Mutations in p53, found in most cancers, lead to uncontrollable cell division. (medscape.com)

The metastasizing cells penetrate the blood vessel wall by invasiveness, and migrate in the circulation, extravasate out of the blood vessels, colonize in the distant tissue, initiate angiogenesis, and finally grow at the new site ( 2 , 3 ). (frontiersin.org)
Thus far, studies on IGF-1R expression have been performed mainly on tumor tissue sections using immunohistochemistry. (snmjournals.org)
Under normal circumstances, turnover of epithelial cell lineages occurs constantly in every 2-7 days but this process become faster during tissue repair and wound healing [ 5 ]. (biomedcentral.com)
This coupling has the benefit of neutralising the toxicity of the active ingredient during its migration through the subcutaneous tissue to the bloodstream, where various enzymes will then break the bond between polymer and active ingredient. (universite-paris-saclay.fr)
Once the polymer has reached a certain length, a water-soluble prodrug is obtained which can be injected subcutaneously, without observing any stagnation or damage to the skin or subcutaneous tissue. (universite-paris-saclay.fr)
Activation of myostatin signaling in muscle tissue has been demonstrated to be critical to enhancing muscle catabolism, which causes muscle wasting in cancer cachexia ( 22 ). (spandidos-publications.com)
Logarithmically growing cancer cells were seeded at optimized densities (8 × 10 2 cells/well) for each examined cell line onto individual wells of 96-well polystyrene tissue culture-treated microplates (3598, Corning, Corning, NY). (beingmedicos.com)
Roche is also the global leader in in vitro diagnostics and tissue-based cancer diagnostics, as well as a front-runner in diabetes management. (pharmalive.com)
Tumorigenicity in cell lines has been described as the process by which neoplastic cells growing in tissue culture form tumors when inoculated into an animal(6 7 Multiple xenograft models exist that provide for the observation of the tumorigenicity of a cancer cell line(8). (cancerhugs.com)
A new technique has been presented that results in an acceleration of delayed primary healing with full thickness skin and subcutaneous tissue coverage. (who.int)

Shanghai Model Organisms Center provides multiple types of tumor-bearing mouse models for cancer research and drug efficacy testing, including cell line-derived xenograft model (CDX) and patient-derived xenograft model (PDX). (modelorg.com)

Different types of tumors have different responses. (bcmj.org)

For treatment of neuroendocrine cancers (i.e., carcinoid tumors and pancreatic endocrine tumors) involving the liver. (aetna.com)

Gastric cancer (GC) is a common malignant tumor originating from gastric mucosa epithelial cells, and its onset is relatively insidious. (frontiersin.org)
When adequate outgrowth of epithelial cells was noticed tumor cells had been detached using 0.125% trypsin and plated into new culture flasks. (cancerhugs.com)
Three microscopic fields per section were analyzed, in order to evaluate the mean epithelial cells layer thickness and counting of blood vessels. (bvsalud.org)

a Representative subcutaneous tumors (left)/orthotopic transplantation tumors (right) collected from Hepa1-6-bearing C57BL/6 mice. (thermofisher.com)

PD-L1 CAR haNKs reduced levels of macrophages and other myeloid cells endogenously expressing high PD-L1 in peripheral blood from patients with head and neck cancer. (elifesciences.org)
The frequency of treatment will initially be once a week for 3 weeks and then biweekly or monthly until 24 months, depending on the response of myeloid suppressor cells (MDSC) on days 21 and 28. (who.int)

Using a panel of MHCII/Aq-restricted T-cell hybridoma lines that specifically recognize an immunodominant COL2 epitope (COL2259-273), we found that NIH/3T3 fibroblasts activate several T-cell clones that recognize the posttranslationally glycosylated or hydroxylated COL2259-273 epitope. (bvsalud.org)
Interestingly, NIH/3T3 cells, but not destructive LS48 fibroblasts, synovial, dermal, or thymic fibroblasts, were able to stimulate the HCQ.3 hybridoma and other COL2-specific T-cell hybridomas. (bvsalud.org)
Our experiments revealed that NIH/3T3 fibroblasts are able to activate COL2-specific T-cell hybridomas even in the absence of COL2 or a posttranslationally modified COL2 peptide. (bvsalud.org)
Nontumorigenic pancreatic human cell line HPNE and normal human fibroblasts were largely spared. (fdxbhc.com)
A prominent involvement of TME was revealed in CI-deficient tumors, characterized by the abundance of cancer associated fibroblasts, tumor associated macrophages and preservation of osteocytes and osteoblasts in the mineralized bone matrix. (crick.ac.uk)

These studies suggest that there is a bi-directional crosstalk between macrophages and CSCs that promotes stemness renewal and tumor associated macrophage polarization. (springer.com)
Interferons function as biologic response modifiers, enhancing phagocytosis and free radical production in macrophages, as well as increasing the activity of natural killer cells. (medscape.com)
It is able to protect blood macrophages from free radical attack during and after the radiation allowing these cells to continue to carry their important functions in the irradiated body and release factors important to the restoration of normal bone marrow production. (digitalnaturopath.com)

Surgical resection is the only known potentially curative treatment for patients with primary or metastatic liver tumors. (bcmj.org)

This uncontrolled mass then forms a malignant tumour. (universite-paris-saclay.fr)

In pancreatic cancer cells a cytosolic metabolic enzyme, wild-type isocitrate dehydrogenase 1 (wtIDH1), enables adaptation to these conditions. (nature.com)
Intra-hepatic microspheres for metastases from esophageal cancer, gallbladder cancer, uveal melanom a, liver metastases of pancreatic adenocarcinoma, and other indications not listed above. (aetna.com)
We have previously shown that gemcitabine sensitizes human pancreatic carcinoma cells against CTL-mediated lysis. (uni-muenchen.de)
Unresectable, locally advanced/metastatic pancreatic or biliary tract cancer. (medscape.com)
Cancer stem cells (CSCs) are suggested to be critical and responsible for tumor development, drug resistance and cancer relapse, therefore, an effective antitumor therapy against pancreatic cancer should deal with pancreatic CSCs. (fdxbhc.com)
Edelfosine was effective against primary cultures from pancreatic cancer patients and their corresponding pancreatic CSCs. (fdxbhc.com)
Pancreatic cancer is one of the most lethal malignancies with a poor and gloomy prognosis and the highest mortality-to-incidence ratio. (fdxbhc.com)
Pancreatic cancer remains an incurable malignancy, and current therapies are ineffective. (fdxbhc.com)
We isolated cancer stem cells (CSCs) from the human PANC-1 pancreatic cancer cell line as CD44+CD24+EpCAM+ cells. (fdxbhc.com)
These CSCs form pancreatic cancer spheres or spheroids and develop tumors in SCID mice after subcutaneous injection of as few as 100 cells per mouse. (fdxbhc.com)
Primary cultures from pancreatic cancer patients were sensitive to edelfosine, as well as their respective isolated CSCs. (fdxbhc.com)
These data suggest that pancreatic CSCs isolated from established cell lines and pancreatic cancer patients are sensitive to edelfosine through its accumulation in the endoplasmic reticulum and induction of endoplasmic reticulum stress. (fdxbhc.com)
Edelfosine accumulates in the endoplasmic reticulum (ER) of pancreatic CSCs, leading to persistent ER stress and eventually to cell death. (fdxbhc.com)
Autophagy is triggered in CSCs as a protective signal to ER stress following edelfosine treatment, and thereby the combination of endoplasmic reticulum targeting with the action of autophagy inhibitors potentiates the proapoptotic activity of edelfosine against CSCs, and represents a promising approach to pancreatic cancer therapy. (fdxbhc.com)

Results of treatment of 255 patients with metastatic renal cell carcinoma who received high-dose recombinant interleukin-2 therapy. (medscape.org)

4 The mitochondrial membrane potential of cancer cells (∼−220 mV) is more negative than that of normal cells (∼−160 mV). 5 Therefore, mitochondria have been regarded as a novel target for cancer therapy. (rsc.org)

Results show the in vitro invasion of cystatin C over-expressing cells was dramatically inhibited. (biomedcentral.com)

Restoring antitumor immunity with dendritic cell reprogramming strategies. (lu.se)
On the other hand, due to lack of specificity, cationic surfactant may cause certain side effects, which affect its antitumor activity and application in cancer therapy. (rsc.org)
The antitumor ether lipid edelfosine colocalized with the endoplasmic reticulum in both PANC-1 cells as well as PANC-1 CSCs by using a fluorescent edelfosine analog, and induced an endoplasmic reticulum stress response in both PANC-1 cells and PANC-1 CSCs, with a potent CHOP/GADD153 upregulation. (fdxbhc.com)

Non-small cell lung cancer (NSCLC) is the most frequent type occurring in about 85% of cases [ 2 ], mainly presenting with an adenocarcinoma (LUAD) or squamous cell lung cancer (SqCC) histology [ 3 ]. (biomedcentral.com)
Check with your doctor or nurse squamous cell any of the head side effects occur disease progressed within six reactions of starting mild and in combination with an redness inhibitor dryness of endocrine skin, in extravasation, with swelling of the vein treatment of completely in with V600 mutation Lenvatinib in combination with everolimus for treated advanced renal cell. (sharonspride.com)
The similarity in marker manifestation and tumorigenic behavior between the primary tumor and the producing cell collection strongly shows that the immortalized cell series resembles the principal tumor it had been derived from and an important analysis tool to the analysis of mind and throat squamous cell carcinomas in youthful patients. (cancerhugs.com)
Introduction Set up cell lines are simply as different as the top and throat squamous cell carcinoma principal tumors that they are produced. (cancerhugs.com)
Head and neck squamous cancers are rare in women and much more unusual in women that are pregnant extremely. (cancerhugs.com)

It is required by FDA that the potential effects of tumor control and toxicity be defined using the naked antibodies produced under GMP conditions, In those situations where patients with recurrent malignancies are to be studied we have come to realize that a number of factors can influence the response to monoclonal therapy. (jcancer.org)

As a tumor grows, a blood supply must be grown from the host (angiogenesis). (dvm360.com)

In recent years, our group has focused on the effect of desmopressin in combination with docetaxel in different prostate cancer cell lines in vitro as well as in preclinical models including xenograft animal models ( 9 , 10 ). (iiarjournals.org)
It is also silly things like ovarian cancer, though it way streetmy is an androgen receptor very sympathetic which has added prostate cancer that progresses you low testosterone if (known as castration better is the aches receptor pains approved for i or we have to live with but it testosterone got me as Vantas is treatment of advanced prostate. (sharonspride.com)
In other malignancies, such as lung and prostate cancers, several agents have been studied, but no strategies have been proven effective. (medscape.com)

Cholangiocarcinoma is an aggressive type of liver cancer with few effective treatment options. (springer.com)
The results showed that lycopene reduced the number of metastatic tumors in the lungs, which was further suppressed by the combined treatment with sorafenib. (frontiersin.org)
Patients with breast cancer lesions that express IGF-1R may benefit from treatment with anti-IGF-1R antibodies. (snmjournals.org)
These results demonstrate the potential of CTAC@MSNs-HSA in cancer therapeutics as well as providing insights into mitochondrion-targeting treatment. (rsc.org)
10-12 Noticeably, cationic surfactant is more extensively used in tumor treatment than other types of surfactants, such as anionic and nonionic surfactant. (rsc.org)
Thus, ChoK constitutes a novel bona fide molecular target for the treatment of breast cancer patients. (aacrjournals.org)
The elevated numbers of MDSC at day 10 after treatment may inhibit the induction of tumor specific T cells. (bmj.com)
Therefore depleting MDSC in the recipient mouse with anti-Gr1 antibody in the early phase of the LRAST treatment could be a promising approach to improve anti-tumour efficacy. (bmj.com)
Following the last treatment, tumors were excised and measured. (iiarjournals.org)
Results: Docetaxel treatment resulted in a significant reduction in tumor volume compared to control. (iiarjournals.org)
Aetna considers percutaneous ethanol injection (PEI) medically necessary for the treatment of hepatocellular cancers (HCC) without extra-hepatic spread. (aetna.com)
Immunotherapy with dendritic cells and/or cytokine-induced killer cells for the treatment of hepatocellular carcinoma. (aetna.com)
The aim is to make this therapy more comfortable, more effective, and thus revolutionise cancer treatment. (universite-paris-saclay.fr)
Consult an expert doctor at Yashoda Hospitals to know more about Herceptin and cancer treatment. (yashodahospitals.com)
No. Consuming alcohol during cancer treatment is not advisable by the doctors. (yashodahospitals.com)
Consequently, a novel strategy for the clinical treatment of cancer-induced muscle wasting is urgently required, and research on this subject is highly necessary ( 2 ). (spandidos-publications.com)
The identification of novel targets is of paramount importance to develop more effective drugs and improve the treatment of non-small cell lung cancer (NSCLC), the leading cause of cancer-related deaths worldwide. (biomedcentral.com)
Surprisingly, we previously found that mice deficient in iNKT cells developed spontaneous CD8 + T cells responses partially effective at inhibiting metastases in mice bearing the 4T1 mammary carcinoma, and showed a markedly improved response to treatment with local radiotherapy and anti-CTLA-4 antibody compared to wild type (WT) mice. (biomedcentral.com)
To determine if the improved response to treatment in the absence of iNKT cells was independent from the immunotherapy employed, 4T1-tumor bearing WT and iNKT −/− mice were treated with local radiotherapy in combination with antibody-mediated CD137 co-stimulation. (biomedcentral.com)
CD1d blockade restored the number of DC in WT mice, improved T cell priming in draining lymph nodes and significantly enhanced response to treatment. (biomedcentral.com)
In recent years, virochemotherapy has been proposed as a potential treatment for chemotherapyresistant cancer. (elsevierpure.com)
However, pretreatment of WiDr cells with oxaliplatin enhanced the oncolytic activity of CVA11, and the combination therapy was more cytotoxic than either oxaliplatin treatment or CVA11 infection alone. (elsevierpure.com)
The treatment was applied to established subcutaneous solid lesions (5-15 mm in diameter) by percutaneously placed electrodes after local or systemic injection of various chemotherapeutic drugs such as: cisplatin, taxol, 5-fluorouracil, carmustine, doxorubicin, or bleomycin. (tau.ac.il)
Cured mice showed increased resistance to a tumor challenge, resistance which was abolished by treatment with an immunosuppresive drug. (tau.ac.il)
Our results indicate that LEFCT-EC is a powerful tool for tumor destruction that opens a promising approach for the treatment of human solid malignancies. (tau.ac.il)
Safety and clinical activity of adenosine A2a receptor (A2aR) antagonist, CPI-444, in anti-PD1/PDL1 treatment-refractory renal cell (RCC) and non-small cell lung cancer (NSCLC) patients. (medscape.org)
Oral keratosis with atypia is an ideal model for the study of head and neck cancer development and chemoprevention because the lesions are readily accessible to visual examination, diagnostic sampling, and evaluation of response to treatment. (medscape.com)

The American Cancer Society has reported 101,340 new cases of colon and 39,870 cases rectal cancers and 49,380 deaths in 2011 in the US. (biomedcentral.com)
Normal human colon consists of millions of crypts, each containing about 2000 cells. (biomedcentral.com)
A fourth category Paneth cell is occasionally present in ascending colon or in certain disease condition [ 4 ]. (biomedcentral.com)
The WiDr cell line is a human colon cancer cell line that was derived from the tumor of a patient in 1971. (xenograft.net)
WiDr cells are commonly used in cancer research to study the biology of colon cancer and test new therapies. (xenograft.net)
In the present study, we established models of ECC and late cancer cachexia (LCC) and compared different stages of cancer cachexia using two cancer cachectic mouse models induced by colon-26 (C26) adenocarcinoma or Lewis lung carcinoma (LLC). (spandidos-publications.com)
A-B) Human colon cancer cells genetically engineered to express firefly luciferase gene were injected via carotid artery into nude mice. (modelorg.com)

We demonstrate that low magnesium levels facilitate allosteric inhibition of wtIDH1, which is lethal to cancer cells when nutrients are limited. (nature.com)
Because elevated cysteine protease activity correlates well with highly invasive cancers, inhibition of this activity may be a target for anti-metastatic therapies. (biomedcentral.com)
It is a cytotoxic antimicrotubule agent that binds to the β-tubulin subunit of microtubulin, resulting in stabilization of microtubules and prevention of depolymerization, leading to inhibition of microtubule dynamics, cell-cycle arrest and eventually apoptotic cell death ( 3 , 4 ). (iiarjournals.org)

Here, we examined the anti-lung-metastatic effects and the mechanism of lycopene in combination with sorafenib in C57BL/6 mice xenografted with Lewis lung carcinoma (LLC) cells. (frontiersin.org)
Methods: Bone marrow-derived DC from C57BL/6 mice were loaded with UV-irradiated, syngeneic Panc02 carcinoma cells and were administered subcutaneously. (uni-muenchen.de)

However, several new targeted agents are currently being tested in clinical trials for their efficacy in patients with triple-negative breast cancer ( 10 ). (snmjournals.org)
The injected cell lines grow into established tumors, thus, permitting efficacy studies of the test compounds. (xenograft.net)
The value of utilizing our xenograft service department is highlighted by the ability to completely characterize the efficacy, dose regimen, dose levels and optimal combination ratios of lead compounds for cancer, obesity, diabetes, infections and immunology research. (xenograft.net)
Impact of Baseline Steroids on Efficacy of Programmed Cell Death-1 and Programmed Death-Ligand 1 Blockade in Patients With Non-Small-Cell Lung Cancer. (medscape.org)
Efficacy and safety of entinostat (ENT) and pembrolizumab (PEMBRO) in patients with non-small cell lung cancer (NSCLC) previously treated with anti-PD-(L)1 therapy. (medscape.org)
Kaunitz AM, Darney PD, Ross D, Wolter KD, Speroff L. Subcutaneous DMPA vs. intramuscular DMPA: a 2-year randomized study of contraceptive efficacy and bone mineral density. (cdc.gov)

Human primary tumor cells could also be reprogrammed to increase their capability to present antigen and to activate patient-specific tumor-infiltrating lymphocytes. (lu.se)
CYC116 Establishment from the cell range Primary tumor cells was transported through the operating room towards the laboratory and was cleaned thoroughly in Earle's well balanced salt solution including penicillin streptomycin and amphotericin B. The cells was after that minced by scalpel cutting tool and put into tradition flasks and protected with full Dulbecco?痵 Revised Eagle Moderate (Gibco) including 10% fetal bovine serum L-glutamine penicillin streptomycin. (cancerhugs.com)

Of all the minimally invasive therapies, percutaneous ethanol injection has been the most widely used and accepted worldwide. (bcmj.org)
There are currently many therapies used to fight cancer. (universite-paris-saclay.fr)
Adults with these types of cancer who have received all available conventional therapies or, in the case of biliary tract cancer, are not likely to tolerate or benefit from the standard of care can join an open-label, single-arm, phase 2 study of the investigational agent BI 907828 (from Boehringer Ingelheim). (medscape.com)

Corrigendum: PHF20 promotes glioblastoma cell malignancies through a WISP1/BGN-dependent pathway. (houstonmethodist.org)
Dive into the research topics of 'Corrigendum: PHF20 promotes glioblastoma cell malignancies through a WISP1/BGN-dependent pathway. (houstonmethodist.org)

An alternative to CDX models is the patient derived tumor xenograft (PDX) which consists of implanting human tumor fragments directly in a mouse model. (xenograft.net)
In fact, if we implant human tumor cells in a zebrafish embryo , when the differentiating factors are abundant, these tumor cells get differentiated and reprogrammed. (biava.me)
Contrarily, by implanting human tumor cells after the organogenesis is completed and therefore when the differentiating factors have decreased, tumor cells grow and replicate. (biava.me)

The mechanisms of cancer cachexia are not well understood, but cachexia is correlated with elevated circulating GDF15. (medscape.com)
Natural killer (NK) cell-based immunotherapy may overcome genetic mechanisms of resistance to T cell-based immunotherapy through antigen- and MHC-independent recognition of malignant cells. (elifesciences.org)
To understand the mechanisms of the immunosuppressive function of iNKT cells, dendritic cells (DCs) were analyzed by immunohistochemistry and flow cytometry in WT and iNKT-deficient (iNKT −/− ) mice. (biomedcentral.com)
In the meantime Biava and colleagues' have continued with their research which at the end allowed to identify various molecular mechanisms employed by the differentiation factors of normal stem cells, taken from the embryo of Zebrafish (chosen due to its being the most studied model of embryonic differentiation), to differentiate tumor cells or lead them to a programmed cell death. (biava.me)
The basic cancer-related chemical and biological sciences, pathology, and epidemiology have contributed to (1) the understanding that antimutagenesis and antiproliferation are the important general mechanisms of chemoprevention and (2) the development of antimutagenic and antiproliferative agents as potential chemopreventive drugs. (medscape.com)

The IGF-1R is a transmembrane receptor expressed in many human cancers, including 36% of all triple-negative breast carcinomas ( 11 ). (snmjournals.org)
Percutaneous ethanol injection is inexpensive, easy to perform, and produces good clinical results for hepatocellular carcinomas (HCCs). (bcmj.org)
Previous studies have shown that pretargeting allows rapid visualization of renal cell carcinomas (RCC) with an 111 In-labeled bivalent peptide. (snmjournals.org)

We noted direct coculturing increased stemness among CSC populations and induced both M1 (CD80 and HLA-DR) and M2 (CD163) tumor associated macrophage polarization. (springer.com)
According to unitarian theory, proposed in 70s, all four cell lineages within the gastrointestinal epithelium are clonal populations derived from a slowly cycling clonogenic stem cells (SC) [ 6 ]. (biomedcentral.com)
The PDX model avoids concerns with the CDX model since the tumor is never grown on plastic and there is no selection for single cell populations. (xenograft.net)
[ 1 ] The success of several clinical trials in cancer prevention in high-risk populations suggests that chemoprevention is a rational and appealing strategy. (medscape.com)

Murine lung adenocarcinoma cell lines (344SQ and 393P) were obtained from Dr. Jonathan Kurie at MD Anderson Cancer Center (Houston, TX) and were originally derived from K-ras LA1/ + p53 R172HΔg/ + engineered mice 24 . (beingmedicos.com)
Murine adenocarcinoma lung cancer 344SQ cells (0.5 × 10 5 cells) were injected subcutaneously into male 129/Sv mice (Charles River Laboratories, Wilmington, MA). (beingmedicos.com)

To this topic, lycopene had been demonstrated to have synergism from the combination of oxaliplatin in a human ovarian cancer cell line ( 20 ), suggesting that the adjuvant property on the anticancer of lycopene. (frontiersin.org)

However, it also points out the weaknesses of immunotherapy, as not all tumors respond to therapy and the co-administration of different immunomodulators may be severely limited due to their systemic toxicity. (mdpi.com)

Anatomy12

Organisms7

Diseases79

Chemicals and Drugs62

Analytical, Diagnostic and Therapeutic Techniques and Equipment55

Phenomena and Processes43

Disciplines and Occupations1

Information Science3

Health Care11

Solid tumors7

Microenvironment11

Inhibited tumor growth1

Melanoma21

Proliferation14

Chemotherapy30

Metastasis20

Xenografts7

Progression5

Apoptosis10

Colorectal13

Tissues9

Anti-tumor8

Recurrence4

Growth27

Immune23

Therapeutic13

Antigens8

Mice with subcutaneous3

Vivo10

Survival11

Intravenous5

Proteins6

Assays3

Abstract2

Mutations2

Tissue10

Xenograft model1

Types of tumors1

Neuroendocrine1

Epithelial cells3

Orthotopic transplantation1

Myeloid2

Fibroblasts5

Macrophages3

Liver tumors1

Malignant tumour1

Pancreatic14

Renal cell carc1

Mitochondrial1

Dramatically inhibited1

Antitumor3

Squamous5

Effects of tumor1

Angiogenesis1

Prostate3

Treatment27

Colon7

Inhibition3

C57BL2

Efficacy6

Primary tumor2

Therapies3

Malignancies2

Human tumor3

Mechanisms5

Carcinomas3

Populations4

Adenocarcinoma2

Ovarian cancer1

Toxicity1