Cancer cell lysis cytotoxic t cells cell cycle. Medical search. Frequent questions

Due to the unobvious early symptoms and the influence of some adverse factors such as tumor heterogeneity and low immunogenicity, patients with advanced gastric cancer (AGC) cannot benefit significantly from treatments such as radical surgical resection, radiotherapy, chemotherapy, and targeted therapy. (frontiersin.org)
The number of cycles of preoperative chemotherapy should be low (3-4) to avoid increased postoperative morbidity. (bvsalud.org)
Adjuvant chemotherapy has become the main treatment for breast cancer in China, and about 81.4% of patients with invasive breast cancer begin chemotherapy treatment [5]. (researchsquare.com)
Our studies showed that the level of brachyury expression directly correlates with resistance to cytotoxic treatments and that treatment in vitro or in vivo with cycles of chemotherapy selects for a population of highly mesenchymal, invasive and brachyury positive tumor cells. (nih.gov)
The current standard of care for locally advanced non-small cell lung cancer (NSCLC) includes radiation, chemotherapy, and surgery in certain individualized cases. (frontiersin.org)
Prior to the advent of cytotoxic chemotherapy, lung cancer at all stages was treated surgically or by radiation alone ( 5 , 6 ). (frontiersin.org)
Presently, stage III lung cancer is managed with a combination of chemotherapy, radiation therapy, and sometimes surgery but the two major challenges in improving outcomes of the treatment of this disease remain local control and metastatic spread. (frontiersin.org)
Resistance to chemotherapy is when the cancer cells do not respond to the drugs. (savedelicious.com)
The drug should be administered only by healthcare professionals experienced with cancer chemotherapy. (mrmed.in)
As per the Cairo-Bishop criteria, laboratory and clinical TLS is typically diagnosed within 3 days before and 7 days after cytotoxic chemotherapy is started. (touchoncology.com)
By comparison, TLS in patients with solid organ tumours treated with cytotoxic chemotherapy occurs within 3 days (95% CI 2.9-4.4). (touchoncology.com)
As opposed to cytotoxic chemotherapy, TKIs target specific mutated kinases that promote tumour angiogenesis and neoplastic cells growth, proliferation, and resistance to apoptosis. (touchoncology.com)
In combination with the medicines melphalan and prednisone, for patients whose disease has not been previously treated and are unsuitable for high-dose chemotherapy with blood stem cell transplantation. (medicines.org.uk)
In combination with the medicines dexamethasone or dexamethasone together with thalidomide, for patients whose disease has not been previously treated and before receiving high-dose chemotherapy with blood stem cell transplantation (induction treatment). (medicines.org.uk)
These finding are particularly beneficial in the treatment of recurrent cancer when maintaining a good quality of life during chemotherapy is a priority and allows patients to have a natural, nutritional approach to preventing and managing chemotherapy adverse effects. (researchgate.net)
Autophagy can be either cytoprotective or cytotoxic in response to stress, chemotherapy or irradiation [ 2 - 4 ]. (aging-us.com)
Treatment with granulocyte colony-stimulating factor is used to stimulate neutrophil production and prevent bacterial infections after cancer chemotherapy and with severe chronic neutropenia. (msdmanuals.com)
Patients with prolonged neutropenia after hematopoietic stem cell transplantation or chemotherapy and patients receiving broad-spectrum antibiotics and high doses of corticosteroids are predisposed to fungal infections. (msdmanuals.com)
BT-ON013 trade name] treatment should only be initiated by a health care provider experienced in the administration of cytotoxic chemotherapy (see section 4.4), and should be administered by a health care provider only. (who.int)

The expression of anti-inflammatory cell signaling molecules, including c-Jun N-terminal kinase (JNK), p38, extracellular signal regulated kinase (ERK), Akt, nuclear factor-κB (NF-κB), inhibitory-κBα (IκBα), iNOS and COX-2, was evaluated by western blot analysis. (spandidos-publications.com)

Fusions with older in comparison with immature DCs induced higher degrees of T-cell proliferation and activation as evaluated by intracellular IFN-γ appearance and more powerful cytotoxic T-cell activity against the tumor cells. (tech-strategy.org)
3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT)-test was used to observe the proliferation of human breast cancer MCF-7 and MDA-MB-231 cells induced on VALD-3. (researchsquare.com)
In addition, AKT/mTOR signaling and MAPK signaling were inhibited by JIB extract to suppress melanoma cell growth and proliferation. (medsci.org)
The results demonstrated that JIB extract combined with cisplatin enhanced the inhibition of cell growth, proliferation, and survival through the obstruction of cell cycle progression and AKT/mTOR and MAPK signaling as well as the induction of cell apoptosis. (medsci.org)
Most cancer chemotherapeutic drugs affect only one characteristic aspect, which is uncontrolled proliferation [3]. (savedelicious.com)
Quercetin acts as a potent anti-cancer agent by attenuating processes related to tumor growth, including oxidative stress, apoptosis, proliferation, angiogenesis, and metastasis. (imuno-medica.ro)
In cell coculture assays, ICOVIR-15K-cBiTE-mediated oncolysis resulted in robust T-cell activation, proliferation, and bystander cell-mediated cytotoxicity. (aacrjournals.org)
Bone marrow DCs from Wistar (allograft group) and Sprague Dawley (SD) (homograft group) rats were electrically fused with the SD-derived osteosarcoma cell line UMR106 to generate a DC-osteosarcoma fusion (DOF) tumor vaccine, which was co-incubated with SD T lymphocytes to stimulate T cell proliferation. (geneticsmr.com)
We cocultured cytokine-induced killer (CIK) cells with dendritic cells (DCs) in vitro and investigated their proliferation, immunophenotype changes, secretory cytokine levels, and their antitumor effects on acute myeloid leukemia (AML) cells. (geneticsmr.com)
Our cell-based assays are strategically designed based on various factors such as disease states, proliferation, and cytotoxicity. (marinbio.com)
Cell proliferation was measured with CellTiter-Glo (Promega, Wisconsin, USA). (marinbio.com)
Application of the client drug led to cell proliferation with the two standards showing precise and identical results. (marinbio.com)
Cell viability/proliferation assays, cell cycle analysis by flow cytometry, immunodetection of specific histone and p53 acetylation marks, western blotting, siRNA and RT-qPCR. (biomedcentral.com)
Although treatment with curcumin, garcinol or the garcinol derivative LTK-14 hampered MCF7 cell proliferation, differential effects of these compounds on histone modifications were observed. (biomedcentral.com)
It can either inhibit or facilitate tumor proliferation by influencing local resistance to growth, interactions between cancer cells and the immune system, and the formation of metastases (Anari, Ramamurthy, and Zibelman 2018). (humankinetics.com)
Moreover, LBF-14 was proved to inhibit the proliferation of B16F10 melanoma cell by disrupting the cytoplasmic membrane and binding to genomic DNA to prevent transcription. (jcancer.org)
previously demonstrated that native BF-30 may selectively inhibit the proliferation of melanoma cells via in vitro permeabilization of cytoplasmic membrane and DNA-binding, and exerted the outstanding anti-cancer effects in B16F10-bearing mice [ 4 ]. (jcancer.org)
Sorafenib (Sor) can block receptor tyrosine kinases, which are involved in the development of new blood vessels, as well as cell proliferation as a result [ 22 ]. (biomedcentral.com)
On the other hand, ALL is caused by excessive proliferation of B or T lymphocyte precursors and accumulation of blast cells in the bone marrow, resulting in the filling of the bone marrow space and finally the suppression of hematopoiesis in the bone marrow, which eventually leads to anemia, thrombocytopenia and becomes neutropenic [ 6 , 7 ]. (springeropen.com)

Despite the existence of a highly immunosuppressive tumor environment, adenovirus-infected cells can nonetheless be efficiently cleared by infiltrating cytotoxic T lymphocytes (CTL) without compromising tumor burden. (aacrjournals.org)
tumor-cytotoxic effects of cytotoxic T lymphocytes (CTLs) were measured by the MTT assay. (geneticsmr.com)
It is mainly expressed on mature cytotoxic T lymphocytes [ 7 , 8 ], and it can inhibit T cell function by binding with PD-L1 or PD-L2 ligand, which is mainly expressed on the surface of tumor cells, to induce immune tolerance and limit autoimmunity [ 9 ]. (jcancer.org)

Flow cytometry analysis showed that VALD-3 triggered cell cycle arrest and induced apoptosis of breast cancer cells. (researchsquare.com)
Furthermore, Tan IIA-induced apoptosis and mitochondrial membrane potential changes were also further demonstrated by DNA fragmentation, single-cell gel electrophoresis assay (SCGE), and flow cytometry methods. (hindawi.com)
We constructed a non-contact co-culturing system and humanized xenograft tumor mice model to detect the influence of GC microenvironment on NK-92 or primary human NK cells viability by flow cytometry. (biomedcentral.com)

As an emerging cancer immunotherapy, oncolytic virotherapies (OVTs) can not only selectively lyse cancer cells, but also induce a systemic antitumor immune response. (frontiersin.org)
To explore the chance of using myeloma cells as the foundation of tumor antigens for immunotherapy myeloma cell lysate-specific CTLs had been generated from sufferers by culturing T cells with autologous DCs pulsed with freeze-thaw lysate from myeloma cells 43. (tech-strategy.org)
Our laboratory has identified the T-box transcription factor brachyury as a novel tumor antigen, a driver of human tumor EMT and drug resistance, and a target for T-cell mediated immunotherapy. (nih.gov)
Dr. Palena is active in the area of tumor immunology and cancer immunotherapy. (nih.gov)
X. Fang , Jiang, C. , and Xia, Q. , " Effectiveness evaluation of dendritic cell immunotherapy for osteosarcoma on survival rate and in vitro immune response " , vol. 14, pp. 11763-11770, 2015. (geneticsmr.com)
We are pleased the FDA has granted full approval for BLINCYTO, the first FDA-approved CD19-directed CD3 T-cell engager BiTE ® immunotherapy and the first to be FDA-approved for MRD in 2018,' said David M. Reese , M.D., executive vice president of Research and Development at Amgen. (gurufocus.com)
Immunotherapy tries to boost the immune system so it is better at targeting and killing tumor cells. (humankinetics.com)
Immune cells and their cytokines have different roles before and after the establishment of a tumor, which can either enhance or impair clinical outcomes of immunotherapy. (humankinetics.com)
Cancer immunotherapy has advanced by the use of chimeric antigen receptor (CAR) T cells, which are engineered to express synthetic receptors that direct T cells to surface tumor antigens. (humankinetics.com)
Treatment innovations to genetically reengineer CAR T cells to counter inhibitory influences found in the tumor microenvironment and new immunotherapy drug combinations are being considered as ways to augment the activity of CAR T cells (Kosti, Maher, and Arnold 2018). (humankinetics.com)
Whether C. tropicalis participates in the progression of CRC and immunotherapy resistance through regulating the tumor cell-intrinsic PD-1 remains to be further elucidated. (jcancer.org)

BiTE antibodies consistently show a high potency of redirected lysis in vitro , and high antitumor activity in various animal models. (aacrjournals.org)
In collaborative studies, we have developed a recombinant yeast-brachyury vector and characterized its ability to induce CD8+ and CD4+ brachyury-specific T cell-immune responses in vivo in murine models and in vitro with human cells. (nih.gov)
The aim of the present investigation was to elucidate the cellular mechanisms whereby Tanshinone IIA (Tan IIA) leads to cell cycle arrest and apoptosis in vitro in keratinocytes, the target cells in psoriasis. (hindawi.com)
We investigated the effects of various concentrations of Tan IIA (5-10 μ g/mL) on mouse keratinocytes and human HaCat cells in vitro to confirm this hypothesis. (hindawi.com)
Additionally, MarinBio specializes in in vitro cell-based assay testing services for clinical and pre-clinical studies, including method development, qualification, validation, transfer, lot-release testing, and potency testing according to guidelines from both FDA and International Council for Harmonization (ICH). (marinbio.com)
Scientific Methods: In vitro growth inhibition assays were completed with AHCC alone and in combination with PLD in panel of human cancer cell lines and findings confirmed in vivo in an ovarian cancer xenograft mouse model. (researchgate.net)
C1QBP knockdown and overexpression cells were established via lentiviral infection and subjected to apoptosis and ROS assay in vitro . (medsci.org)
Knockdown of PD-1 enhanced SW480 viability in-vitro, while overexpression of PD-1 diminished cell viability. (jcancer.org)
Therefore, the current study used integrated in vitro and in silico approaches to figure out Amy and Sor's possible synergistic activity in targeting AMPK/mTOR and BCL-2 for anti-angiogenesis and apoptosis cell death in HepG2 cells. (biomedcentral.com)

This study is the first to show that VALD-3 induces apoptosis and cell cycle arrest in human breast cancer cells by suppressing Wnt/β-catenin signaling, indicating that it could be a potential drug for the treatment of breast cancer. (researchsquare.com)
We have recently demonstrated, for example, that brachyury overexpression induces the secretion of interleukin-8 (IL-8) and expression of IL-8 receptors, and that IL-8 signaling is critical for maintaining the mesenchymal characteristics of human tumor cells. (nih.gov)
Studies have shown that xanthine dehydrogenase (XDH)-derived reactive oxygen species (ROS) accelerates tumor growth, and also induces mutations or produces cytotoxic effects concurrently. (medsci.org)
The programmed cell death 1 (PD-1) receptor is an immune checkpoint molecule that induces immune tolerance and mediates the immune escape of tumor cells. (jcancer.org)
This inhibition of AMPK ultimately leads to inhibition of mTOR and thus induces apoptosis in the HepG2 cells. (biomedcentral.com)

After repeated rounds of T-cell excitement with idiotype-pulsed autologous DCs idiotype-specific T-cell lines which contains both Compact disc4+ and Compact disc8+ T cells had been produced and propagated through the peripheral bloodstream mononuclear cells (PBMCs) of myeloma sufferers. (tech-strategy.org)
Idiotype-specific proliferative replies were noticed when these T cells had been rechallenged using the autologous however not allogeneic idiotype-pulsed DCs. (tech-strategy.org)
With a regular 51chromium-release assay our outcomes demonstrated that idiotype-specific CTLs not merely known and lysed autologous idiotype-pulsed DCs but also considerably killed autologous major myeloma cells. (tech-strategy.org)
These cell lines proliferated in response to autologous major myeloma cells and DCs pulsed with autologous however not allogeneic tumor lysate and secreted mostly IFN-γ and tumor necrosis aspect (TNF)-α indicating they are YIL 781 type-1 T cells (Th1 and Tc1). (tech-strategy.org)
The CTLs got solid cytotoxic activity against autologous tumor lysate-pulsed DCs and major myeloma cells. (tech-strategy.org)
DCs were induced from mononuclear cells in the peripheral blood with recombinant human granulocyte macrophage colony stimulating factor (rhGM-CSF) and recombinant human interleukin 4 (rhIL-4), followed by sensitization with lysis of autologous liver cancer cells. (geneticsmr.com)

Recently, increased attention is on antitumor herbs for cancer cure with fewer side effects compared to chemical agents. (ijpsonline.com)

The CAR-containing exosomes express a high level of cytotoxic molecules and inhibit tumour growth. (nature.com)
In summary, although garcinol and curcumin can both inhibit histone acetyltransferase activities, our results show that these compounds have differential effects on cancer cells in culture. (biomedcentral.com)
After extravasation into a tumor, cytotoxic T cells are in a microenvironment rich in tumor-associated immunosuppressive cells including tumor-associated macrophages (TAMs), tumor-associated neutrophils (TANs), myeloid-derived suppressor cells (MDSCs), T-regulatory cells (Tregs), and cancer-associated fibroblasts, which release molecules that inhibit or kill the T cell by apoptosis (Martinez and Moon 2019). (humankinetics.com)

Ongoing trials are assessing its efficacy for managing other cancers. (wikipedia.org)
The efficacy and specificity of CRAD on prostate cancer cells were examined in cell culture and animal models. (hindawi.com)
By implementing such strategies, healthcare professionals aim to enhance the efficacy of antiviral drugs while minimising their impact on host cells. (chayadeep.com)
doxorubicin, inducing G2/M cell cycle arrest in human colon cancer, (15) and increasing the therapeutic efficacy of doxorubicin. (imuno-medica.ro)
Moreover, the complexity of tumor microenvironment (TME), which mainly consists of neoplastic cells, stromal cells, immune cells, soluble factors and extracellular matrix, severely diminishes the efficacy of anti-tumor immunity, thus restraining the effects of various immunotherapies developed during the past decades. (biomedcentral.com)

In this study, we investigated the cytotoxic and apoptotic effects of VALD-3, a Schiff base ligand synthesized from o-vanillin derivatives, on human breast cancer cells and the possible underlying mechanisms. (researchsquare.com)

There is increasing evidence that T cells are able to control tumor growth and survival in cancer patients, both in early and late stages of the disease. (aacrjournals.org)
Tumors and tumor-associated cells also secrete VEGF, tumor growth factor, and prostaglandin E2, which impair T cells. (humankinetics.com)
In this study, we first found that high concentrations of C. tropicalis promote tumor growth in cell cultures and xenografts. (jcancer.org)
Moreover, blocking antibody against PD-1 promotes tumor growth both in SW480 cells and mice CRC xenografts in an adaptive immune-independent manner. (jcancer.org)

One of the hallmarks of breast cancer is resistance of tumor cells to cell death. (ijpsonline.com)
However, cancer cells can become multidrug resistant, a phenomenon due to cells expressing mechanisms that cause simultaneous resistance to many different, structurally and functionally, unrelated drugs [6]. (savedelicious.com)
Moreover, we found NK cells with higher GPX4 expression showed resistance to L-KYN induced ferroptosis. (biomedcentral.com)
Despite a large number of promising inhibitors for Ras/Raf/MEK/ERK pathway, recent works show that cancer cells often develop an autophagy-dependent resistance to inhibitors of Ras pathway [ 16 ]. (aging-us.com)
Under physiological circumstances, the resistance of the endothelial cell lining to interactions with platelets and coagulation factors prevents thrombosis. (medscape.com)

This medicine helps to selectively kill the cancer cells rather than the normal, healthy cells. (mrmed.in)

Natural killer (NK) cells play a major role in body's fighting against various types of cancers. (biomedcentral.com)
Ras GTPase is frequently mutated in different types of cancers that correlate with a poor prognosis [ 11 - 15 ]. (aging-us.com)

Likewise, bispecific antibodies for engagement of other cytotoxic immune cells were constructed, for instance, targeting Fcγ RI/CD64 on macrophages and Her2/neu or EGFR on tumor cells. (aacrjournals.org)
The interactions between tumor and immune cells in the local microenvironment are believed to be involved in the growth, metastasis and invasion of GC [ 2 ]. (biomedcentral.com)
The local microenvironment of a tumor (e.g., immune cells, angiogenic cells, lymphatic endothelial cells, and cancer-associated fibroblasts) modulates cancer growth and progression (see figure 13.17). (humankinetics.com)
For example, immune cells such as NK cells and tumor necrosis factor can eliminate abnormal cells before they progress to a tumor. (humankinetics.com)
However, after tumor establishment, the microchemical environment of tumor cells modulates the function of immune cells. (humankinetics.com)
It is mainly expressed in immune cells such as T cells, B cells and monocytes. (jcancer.org)

Clofarabine can stop the bone marrow from making enough red blood cells, white blood cells, and platelets. (wikipedia.org)
We used radiation to obtain a MB49 cell antigen that was sensitive to bone marrow-derived DCs to prepare a DC vaccine. (geneticsmr.com)
All types of leukocytes are made in bone marrow, derived from stem cells. (ishinobu.com)
Acute lymphoblastic leukemia termed as ALL is defined as a type of blood malignancy that is detectable through the accumulation of B and T lymphocyte progenitor cells in the bone marrow [ 4 ]. (springeropen.com)
The clinical presentation of patients with aplastic anemia includes symptoms related to the decrease in bone marrow production of hematopoietic cells (see the image below). (medscape.com)
Low power, H and E showing a hypocellular bone marrow with increased adipose tissue and decreased hematopoietic cells in the marrow space. (medscape.com)
Storage of bone marrow or blood leukemic cells in biobanks is strongly recommended. (cancercentrum.se)
While IAEMH is associated with severe anaemia due to intravascular haemolysis caused by red cell invasion, oxidative injury, auto-antibodies, and/or pathogen-haem interaction, IAIMH is associated with haemophagocytic tri-lineage destruction of haematopoietic precursors in the bone marrow. (bvsalud.org)

Cell counting and MTT assays were used to assess cell viability in the absence or presence of GSP. (spandidos-publications.com)
In addition, cell apoptosis was measured by double staining, DNA fragmentation and annexin V-fluorescein isothiocyanate binding assays. (ijpsonline.com)
Unlock the full potential of your drug discovery process with MarinBio's Cell-Based Assays Services. (marinbio.com)
They play a crucial role in cell-based assays in drug discovery , focusing on signaling pathways, gene expression , among other endpoints. (marinbio.com)
Cell-based assays (bioassays) measure functional effects of drugs to establish their biological relevance and physiological importance. (marinbio.com)
To evaluate anti-tumour effects and mechanism of novel BF-30 derivative via cell-based assays and melanoma-bearing model mice. (jcancer.org)

Despite their efficiency, adoptive T-cell therapies show unique toxicities, which are distinct from those seen with conventional chemotherapies, monoclonal antibodies (mAbs), and small-molecule-targeted therapies. (nature.com)
It may provide a new idea and mechanism for answering why the immune monoclonal antibody treatment is ineffective in cancer patients. (jcancer.org)

May also be given to people with slow-growing (indolent) B-cell non-Hodgkin lymphoma (NHL) that has progressed despite treatment with rituximab or a rituximab-containing regimen within the past 6 months. (drugs.com)
For CLL, Treanda 100mg/m 2 is administered as a 30-minute infusion into a vein on days 1 and 2 of a 28-day treatment cycle. (drugs.com)
The treatment cycle may be repeated up to six times. (drugs.com)
Consider treatment with antihistamines, antipyretics, and corticosteroids in subsequent cycles in patients who have experienced Grade 1 or 2 infusion reactions. (drugs.com)
Therefore, remedies based on the induction of programmed cell death attracted greater attention for cancer treatment [ 8 ]. (ijpsonline.com)
Genetically engineered T cells expressing a chimeric antigen receptor (CAR) are rapidly emerging a promising new treatment for haematological and non-haematological malignancies. (nature.com)
Compared with CAR-T cells, CAR exosomes do not express Programmed cell Death protein 1 (PD1), and their antitumour effect cannot be weakened by recombinant PD-L1 treatment. (nature.com)
Although a strong response was observed for CAR-T cells in patients with treatment-refractory haematologic malignancies, only modest outcomes have been reported in solid tumours. (nature.com)
Her current research is focused on the development of novel immunotherapeutic approaches aimed at targeting critical events in tumor progression with the ultimate goal of designing vaccine platforms and combinatorial therapies for the prevention and/or treatment of metastases in human cancer. (nih.gov)
Clofarabine is a substance that is being studied in the treatment of cancer . (bionity.com)
Therefore, based on clinical experience as well as cytotoxic activity against multiple human cancer cells, we hypothesized that induction of apoptosis is the underlying mechanism for the treatment of psoriasis. (hindawi.com)
By gaining a deeper understanding of the intricacies of antiviral drug interactions with host cells, scientists can strive for more effective and safer treatment options. (chayadeep.com)
The remainder of this review will focus on the different chemotherapeutic agents currently being used for the treatment of cancer and their mechanism of action. (savedelicious.com)
Drugs used in the treatment of cancer are summarised in table 2. (savedelicious.com)
Quercetin in cancer treatment, alone or in combination with conventional terapeutics. (imuno-medica.ro)
Daily topical treatment with CWO induced dramatic regression of pre-malignant skin tumors and a two-fold reduction in cutaneous squamous cell carcinomas. (biorxiv.org)
Long-term use of this medicine may cause tumor lysis syndrome, regular monitoring of blood uric acid levels, potassium, calcium, and creatinine levels after initial treatment is necessary. (mrmed.in)
Before initiating the treatment, inform your physician if you have kidney or liver problems, recent vaccination, or if you have any acute toxicities such as acute inflammation of the mouth, low white blood cell count, platelet count, or any infections. (mrmed.in)
SHSY5Y cells are differentiated into neural cells after seven days' treatment with retinoic acid. (marinbio.com)
In contrast, global levels of acetylated H4K16 and trimethylated H4K20 in MCF7 cells were elevated after garcinol treatment. (biomedcentral.com)
Garcinol treatment alters expression of chromatin modifying enzymes in MCF7 cells, resulting in reprogramming of key histone and p53 PTMs and growth arrest, underscoring its potential as a cancer chemopreventive agent. (biomedcentral.com)
Here we report a severe life-threatening complication of treatment with streptozotocin in a patient with pancreatic island-cell carcinoma. (cancerindex.org)
FOLOTYN is indicated for the treatment of patients with relapsed or refractory peripheral T-cell lymphoma (PTCL). (guidelinecentral.com)
There are a variety of tyrosine kinase inhibitors (TKIs) that are used in oncology for the treatment of malignancies now and consequently there have been increased observations of tumour lysis syndrome (TLS) associated with these drugs. (touchoncology.com)
1 TKIs are now therapies used routinely in the treatment of many solid tumours such as gastrointestinal stromal tumour (GIST), renal cell carcinoma (RCC), hepatocellular carcinoma (HCC), medullary thyroid cancer, breast cancer and non-small-cell lung carcinoma (Table 1) . (touchoncology.com)
Alone or together with the medicines pegylated liposomal doxorubicin or dexamethasone, for patients whose disease is worsening (progressive) after receiving at least one prior treatment and for whom blood stem cell transplantation was not successful or is unsuitable. (medicines.org.uk)
Bortezomib is used for the treatment of mantle cell lymphoma (a type of cancer affecting the lymph nodes) in patients 18 years or older in combination with the medicines rituximab, cyclophosphamide, doxorubicin and prednisone, for patients whose disease has not been previously treated and for whom blood stem cell transplantation is unsuitable. (medicines.org.uk)
You will have to take regular blood tests before and during your treatment with Bortezomib, to check your blood cell counts regularly. (medicines.org.uk)
Before beginning treatment with epirubicin, patients should recover from acute toxicities (such as stomatitis, neutropenia, thrombocytopenia, and generalized infections) of prior cytotoxic treatment. (recallguide.org)
A clinical study to evaluate of the combination of AHCC plus PLD in the treatment of ovarian cancer is being pursued. (researchgate.net)
Industrial Relevance: This study presents an example of the successful integration of a well- known herbal supplement, AHCC, with traditional western medicine cytotoxic agent, pegylated liposomal doxorubicin, for the treatment of recurrent ovarian cancer. (researchgate.net)
For example, the PD-1/PD-L1 treatment have shown outstanding effects on several types of cancer, but the objective response rate in GC was only at 15% [ 4 ]. (biomedcentral.com)
Thus, restoring the number of NK cells in TME is of great significance for GC clinical treatment. (biomedcentral.com)
Treatment of control ERas cells with PD0325901 for 24 h results in mitochondria damage and apoptotic death of a part of cellular population. (aging-us.com)
Fludara is usually given after other cancer medications have been tried without successful response to treatment. (rxlist.com)
Instances of life-threatening and sometimes fatal autoimmune phenomena such as hemolytic anemia , autoimmune thrombocytopenia /thrombocytopenic purpura (ITP), Evans syndrome, and acquired hemophilia have been reported to occur after one or more cycles of treatment with FLUDARA (fludarabine) FOR INJECTION. (rxlist.com)
Furthermore, results of H&E staining prove that chronic treatment of LBF-30 effectively suppressed metastasis and invasion of B16F10 cells. (jcancer.org)
Forced expression of lcn2 or treatment with LCN2 protein increased the sensitivity of astrocytes to cytotoxic stimuli. (jneurosci.org)
The results showed that the expression of anti-apoptotic genes was significantly reduced after treatment of the Jurkat cell line with the BSA-Au nanozymes (p-value of 0.001) as the potential nanodrug while their expression in the normal PBMC was not affected by the nanodrug. (springeropen.com)
Moreover, the cytotoxic effect of the developed nanodrug on the Jurkat cell line was evaluated which illustrated that survival rate in the studied cell line reaches its minimum value (100% lethality, 0.0% survival) after treatment for 48 h. (springeropen.com)

We found L-KYN, mainly generated through indoleamine 2, 3-dioxygenase (IDO) from GC cells, impaired NK cells viability in TME. (biomedcentral.com)

Investigations of the relative efficacies from the compounds on recombinant receptors expressed in cell hnes where receptor reserve as well as the endogenous concentration of 5 HT is often experimentally manipulated should really help to answer these concerns. (gabasignaling.com)
NK cells recognize the targets through the biased signals transmitted from active or inhibitory receptors. (biomedcentral.com)
In addition, we proved that colon cancer cell lines express PD-1 receptors. (jcancer.org)

Myeloma plasma cells and myeloma-specific T cells Myeloma tumor cells may include a large number of tumor antigens that may stimulate an elevated repertoire of YIL 781 anti-tumor T cells and result in an induction of more powerful antimyeloma replies. (tech-strategy.org)
The heterokaryons produced by cancer-DC fusion cells combine the equipment needed for immune system stimulation YIL 781 with display of a big repertoire of antigens. (tech-strategy.org)
BLINCYTO is a BiTE ® (bispecific T-cell engager) immuno-oncology therapy that targets CD19 surface antigens on B cells. (gurufocus.com)
or actively by prior immunization of the recipient with graft antigens which evoke specific antibodies and form antigen-antibody complexes which bind to the antigen receptor sites of the T-cells and block their cytotoxic activity. (lookformedical.com)

For example, reduced levels of acetylated H4K16 and trimethylated H4K20 are associated with high tumour grade and poor survival in breast cancer. (biomedcentral.com)
Drug-like molecules that can reprogram selected histone PTMs in tumour cells are therefore of interest as potential cancer chemopreventive agents. (biomedcentral.com)
In this study we assessed the effects of the phytocompounds garcinol and curcumin on histone and p53 modification in cancer cells, focussing on the breast tumour cell line MCF7. (biomedcentral.com)
Thus, drug-like molecules that target chromatin modifying enzymes to reprogram selected histone PTMs in tumour cells may have potential as cancer chemopreventive agents. (biomedcentral.com)
In some cases, such as the c-Kit mutation observed in GIST, tumour cells can be highly "addicted" to one or more oncogenic kinases 2-4 and the inhibition of these kinases with a TKI can lead to a striking tumour response and trigger tumour lysis syndrome (TLS). (touchoncology.com)
The pathophysiology of TLS is characterised by an extensive breakdown of tumour cells releasing intracellular contents into the bloodstream, leading to acidosis, hyperuricemia, hyperphosphatemia, and hyperkalemia. (touchoncology.com)

ABC transporter ABCG2 promotes export of clofarabine-5´-monophosphate and thus limits the cytotoxic effects of this analog in vivo. (wikipedia.org)
We previously established a direct single-cell analysis to simultaneously identify and quantify in vivo CMV-CTL clones after allo-HCT 9 , 10 . (nature.com)
Although virus-based gene therapy is a promising strategy to combat advanced prostate cancer, its current effectiveness is limited partially due to inefficient cellular transduction in vivo . (hindawi.com)
In vivo , CWO induced transcriptional changes in immune-related genes, resulting in cytotoxic T cell-dependent tumor regression. (biorxiv.org)
Notably, intratumoral injection of this cBiTE-expressing adenovirus increased the persistence and accumulation of tumor-infiltrating T cells in vivo , compared with the parental virus lacking such effects. (aacrjournals.org)
In zebrafishes, forced expression of rat lcn2 gene increased the number and thickness of cellular processes in GFAP-expressing radial glia cells, suggesting that lcn2 expression in glia cells plays an important role in vivo . (jneurosci.org)
Our results suggest that lcn2 acts in an autocrine manner to induce cell death sensitization and morphological changes in astrocytes under inflammatory conditions and that these phenotypic changes may be the basis of reactive astrocytosis in vivo . (jneurosci.org)

According to the GLOBOCAN 2020 estimates of incidence and mortality for 36 cancers in 185 countries produced by the International Agency for Research on Cancer (IARC), GC ranks fifth and fourth, respectively, and seriously threatens the survival and health of people all over the world. (frontiersin.org)
Although the survival rate for breast cancer in China has greatly improved, the five-year survival rate is still significantly lower than in Western developed countries. (researchsquare.com)
However, since viruses rely on host cells for their survival and replication, antiviral drugs also interact with the host cells. (chayadeep.com)
A multivariate Cox analysis was performed to show that the intra-tumoral NK cell density was positively related with the overall and disease-free survival of GC patients [ 9 ]. (biomedcentral.com)
Macroautophagy (hereafter referred to as autophagy) plays an important role in cancer cells survival upon various conditions of intra- and extracellular stress. (aging-us.com)
However, the precise role of lcn2 in the cell survival and death has yet to be determined. (jneurosci.org)
The microenvironment of the cell and the interactions of many growth factors have a role in tumor development and survival [ 2 , 7 ]. (biomedcentral.com)

These are capable of connecting any kind of cytotoxic T cell to a cancer cell, independently of T-cell receptor specificity, costimulation, or peptide antigen presentation. (aacrjournals.org)
A skewed preference for BV7 genes and sequential "G" amino acids motif is observed in complementarity-determining region-3 of T cell receptor-β. (nature.com)
Increased binding scores are observed in T-cell clones with complementarity-determining region-3 of T cell receptor-β with a "(G)GG" motif. (nature.com)
An individual T-cell has a specific complementarity-determining region 3 (CDR3) of T cell receptor (TCR)-α and -β, which is a result of the recombination of somatic TCR V-(D)-J genes and junction diversity. (nature.com)
Though the mechanism via which 5 HT, receptor antagonists induce emesis continues to be controversial, evidence from this review displays that, as with cisplatin, a population of 5HT creating cells mediate the emetic effects of 5 HT, receptor antagonists. (gabasignaling.com)
Qu J, Chen Q, Bing Z, Shen S, Hou Y, Lv M, Wang T. C. tropicalis promotes CRC by down-regulating tumor cell-intrinsic PD-1 receptor via autophagy. (jcancer.org)

Pioneering work by Kufer and colleagues ( 6 ) showed that CD3/target antigen-bispecific antibodies of this particular design had an exceptionally high potency, and could likewise engage CD8 + and CD4 + T cells for redirected lysis of cancer cells at very low effector to target (E:T) ratios. (aacrjournals.org)
Predicated on the specificity from the immune system effector substances and cells immunotherapies with particular T cells or healing antibodies may represent book strategies for the treating multiple myeloma soon. (tech-strategy.org)
A constant feedback system between the command chains and effector cells ensures an appropriate response that ends when the threat is extinguished. (ishinobu.com)

extract (JIB extract) for melanoma cells. (medsci.org)
Collectively, our results indicate that JIB extract showed anti-tumor effects and synergized with cisplatin against B16/F10 cells, indicating the possibility of JIB extract to be developed as adjuvant therapy for melanoma. (medsci.org)
Melanoma is a malignant tumor of melanocytes, which are the cells that make the pigment melanin and are derived from the neural crest. (cancer.gov)
Skin cancer is the most common malignancy diagnosed in the United States, and invasive melanoma represents about 1% of skin cancers but results in most deaths. (cancer.gov)
however, melanoma is the most common cancer in young adults aged 25 to 29 years and the second most common cancer in those aged 15 to 29 years. (cancer.gov)
3 ] Ocular melanoma is the most common cancer of the eye, with approximately 2,000 cases diagnosed annually. (cancer.gov)
Melanocytes are also present in normal skin and serve as the source cell for melanoma. (cancer.gov)
In recent years, studies have shown that tumor cell-intrinsic PD-1 plays different roles in the development of melanoma, Liver cancer and lung cancer. (jcancer.org)

To improve the immunogenicity of idiotype proteins we utilized dendritic cells (DCs) as antigen-presenting cells. (tech-strategy.org)
The cytotoxicity was MHC course I- also to a lesser level class II-restricted recommending that myeloma cells could procedure idiotype proteins and present idiotype peptides in the framework of their surface area MHC molecules. (tech-strategy.org)
The adenovirus early region 1 (E1) gene, which comprises E1a and E1b, encodes the viral early proteins that are necessary for adenoviral replication and the consequent oncolysis of permissive host cells. (hindawi.com)
The expression of pro-apoptotic proteins and anti-apoptotic proteins in MCF-7 and MDA-MB-231 cells was investigated by Western blotting. (researchsquare.com)
Autophagy, the type II cell death, is a physiological mechanism involving degradation of intracellular damaged proteins and organelles into membrane vacuoles. (ijpsonline.com)
Targeted therapy drugs are used to target specific genes and proteins of cancer cells to precisely identify and attack specific types of cancer cells. (medsci.org)
New therapies that combine the use of inhibitors of checkpoint proteins that turn off T cell recognition of a tumor, armored CARs (e.g., modified to secrete cytokines such as IL-12) that defeat the immunosuppressive tumor environment, and suppression of other inhibitory factors in the tumor microenvironment can boost CAR T cell success in solid tumors and are being tested in clinical trials (Martinez and Moon 2019). (humankinetics.com)
Iron and BIM (Bcl-2-interacting mediator of cell death) proteins were involved in the cytotoxic sensitization process. (jneurosci.org)

According to recent data, Ras-transformed cells require autophagy to survive and maintain malignant phenotype [ 5 - 10 ]. (aging-us.com)

Additionally, the specific mechanisms of action of different antiviral drugs and their impact on host cells vary, leading to a range of possible side effects. (chayadeep.com)
Molecular mechanisms of action of quercetin in cancer: recent advances. (imuno-medica.ro)

The expression levels of autophagy-related genes, Lc3 and Beclin1 increased in cells treated with 1.5 mg/ml of Solanum nigrum extract. (ijpsonline.com)

An alternative approach to engage T cells for cancer therapy are antibodies, which are bispecific for a surface target antigen on cancer cells, and for CD3 on T cells. (aacrjournals.org)
Here, we review the principle of a new class of bispecific antibodies called BiTE (for "bispecific T-cell engager") antibodies. (aacrjournals.org)
The concept of using such bispecific antibodies to engage cytotoxic T cells for cancer cell lysis was shown by Staerz and colleagues ( 1 ). (aacrjournals.org)
By using just one CD3-specific binding arm, such bispecific antibodies can monovalently bind to all T cells, but do so only with rather low affinity ( 7 ), which will not trigger T-cell signaling by CD3, unless the BiTE antibody is presented to the T cell in a multivalent fashion by a target cell ( 8 ). (aacrjournals.org)
In this study, we tested the hypothesis that tumor-infiltrating T cells could be more effectively activated and redirected by oncolytic adenoviruses that were armed with bispecific T-cell-engager (BiTE) antibodies. (aacrjournals.org)
B cells produce antibodies: tags that stick to pathogens, marking them for destruction. (ishinobu.com)

Potential mechanisms of quercetin in cancer prevention: Focus on cellular and molecular targets. (imuno-medica.ro)
After activation, they can directly lyse the targets by generating cytotoxic molecules, such as perforin and granzyme B. Besides, NK cells also secret amounts of immune regulators, especially IFN-γ, to enhance the overall anti-tumor activity [ 5 ]. (biomedcentral.com)

To evaluate the impact of the COVID-19 pandemic on the mental health and well-being of patients with colorectal cancer, we conducted a prospective longitudinal questionnaire study at a UK tertiary cancer centre. (bvsalud.org)
colorectal cancer, Candida. (jcancer.org)
Colorectal cancer (CRC) is the most common gastrointestinal malignancy which is always accompanied by high metastasis in the United States and the CRC prognosis biomarker is still poor currently [ 1 , 2 ]. (jcancer.org)

Phagocytes are cells that ingest foreign particles and cellular waste. (ishinobu.com)

Cancer cell international 22.1 (2022): 257. (imuno-medica.ro)

We aimed to evaluate dendritic cell (DC) tumor vaccines for preventing liver cancer recurrence and metastasis. (geneticsmr.com)

In this investigation, the role of autophagy and apoptosis in Solanum nigrum fruit extract-induced cytotoxicity in MDA-MB-468, a triple negative breast cancer cell line was studied. (ijpsonline.com)
This study aimed to investigate the cytotoxicity of cytokine-induced killer cells (CIKs) and Her2 epitope peptide-sensitized dendritic cells (DCs), when co-cultured with Her2-positive MCF-7 cells. (geneticsmr.com)

Circulating PSA-positive cells are also strongly associated with metastatic prostate cancer [ 8 ]. (hindawi.com)
The central hypothesis of our research is that immunization against a molecular driver of EMT could lead to the generation of a T-cell immune response that ultimately will eradicate the population of metastatic, drug-resistant cancer cells expressing the EMT target of choice. (nih.gov)
We have shown that elevated levels of brachyury expression in human carcinoma cells induce an EMT, enhance cell migration and invasiveness, and increase metastatic propensity in xenograft models. (nih.gov)
Stage III lung cancer, though heterogeneous in its classification, includes non-metastatic but locally advanced disease with involvement of N1-N3 nodal stations and/or T3 and T4 primaries. (frontiersin.org)
Streptozotocin-induced diabetic ketoacidosis in a patient with metastatic islet-cell carcinoma. (cancerindex.org)

X. Y. Cheng and Li, J. L. , " Biological activity of cytotoxic dendritic cells cocultured with cytokine-induced killer cells and their effect on acute leukemia cells " , vol. 14, pp. 13208-13214, 2015. (geneticsmr.com)
INFα) to activate NK cells and dendritic cells. (humankinetics.com)

Myeloma-specific CTLs may also be propagated and induced through the use of myeloma-DC fusion cells as antigen-presenting cells. (tech-strategy.org)
Myeloma-specific CTLs could possibly be generated by rousing T cells with alternatively. (tech-strategy.org)

JIB extract induced cell cycle arrest at the G 0 /G 1 phase and decreased cyclin and cdk protein expressions. (medsci.org)
Epirubicin inhibits DNA, RNA, and protein synthesis by exerting cytotoxic activity. (mrmed.in)
Complement component 1 Q subcomponent binding protein (C1QBP) plays a vital role in the progression and metabolism of cancer. (medsci.org)
LCN2 protein induced upregulation of glial fibrillary acidic protein (GFAP), cell migration, and morphological changes similar to characteristic phenotypic changes termed reactive astrocytosis. (jneurosci.org)

We tested an essential-oil derivative, camphor white oil (CWO), for anti-tumor activity in a mouse model of keratinocyte-derived skin cancer. (biorxiv.org)
Given that autophagy is initiated upon suppressed mTORC1 activity, a protective autophagy in Ras-transformed cells with a high level of mTORC1 activity appears to be mTORC1-independent [ 20 , 21 ]. (aging-us.com)
One of the mechanisms of high basal autophagy activity in cancer Ras-expressing cells might be associated with high PP2A phosphatase activity targeting directly ULK1-Ser757 that could explain apparent contradiction: maintenance of high mTORC1 functions and high autophagic activity simultaneously [ 22 ]. (aging-us.com)
CARs are designed to augment T cell activity and for persistence in killing target tumors. (humankinetics.com)
Astrocytes, the most abundant glial cell type in the brain, provide metabolic and trophic support to neurons and modulate synaptic activity. (jneurosci.org)

allogeneic stem cell transplantation and donor lymphocyte infusions with or without donor vaccination using patient-derived idiotype and potential program of donor-derived or hRPB14 patient-derived antigen-specific T-cell infusion within this disease may also be discussed. (tech-strategy.org)
Cytomegalovirus reactivation is still a critical concern following allogeneic hematopoietic cell transplantation, and cellular immune reconstitution of cytomegalovirus-specific cytotoxic T-cells is necessary for the long-term control of cytomegalovirus reactivation after allogeneic hematopoietic cell transplantation. (nature.com)
pediatric patients aged 1 year or older with Philadelphia chromosome negative CD19 positive B-precursor ALL which is refractory or in relapse after receiving at least two prior therapies or in relapse after receiving prior allogeneic hematopoietic stem cell transplantation. (gurufocus.com)

To examine whether idiotype-specific T cells can understand and eliminate myeloma cells we produced idiotype-specific cytotoxic T lymphocyte (CTL) lines from myeloma sufferers 42. (tech-strategy.org)

In many cases the antiproloferation action is caused by damage to DNA, which initiates apoptosis and cell death [4]. (savedelicious.com)

Besides, 12% of patients have second- or third-degree skin reactions that are sensitive to light, and about 18% of patients develop cutaneous squamous-cell carcinoma and keratoacanthoma or occurred at the same time [ 6 ]. (medsci.org)
SUMMARY BLURB Essential oil derived from the camphor tree acts by stimulating immune cell-dependent regression of skin tumors in a mouse model of cutaneous squamous cell carcinoma. (biorxiv.org)

Quercetin-mediated cell cycle arrest and apoptosis involving activation of a caspase cascade through the mitochondrial pathway in human breast cancer MCF-7 cells. (imuno-medica.ro)
A substantial synergistic interaction between Amy and Sor was observed (CI 50 = 0.56), which was connected to cell cycle arrest at the S and G2/M stages and increased apoptosis and potential necroptosis. (biomedcentral.com)

Other side effects that may occur include infections or a recurrence of infections, kidney or liver damage, other cancers, and leaking of Treanda into the surrounding skin causing tissue damage. (drugs.com)
Antiviral drugs, while effective in combating viral infections, often come with side effects in host cells. (chayadeep.com)
Antiviral drugs are crucial in treating viral infections, but they often come with side effects in host cells. (chayadeep.com)
Helper and killer T cells respectively coordinate and attack viral infections. (ishinobu.com)
Acute, severe neutropenia, particularly if another factor (eg, cancer) is present, significantly impairs the immune system and can lead to rapidly fatal infections. (msdmanuals.com)
Sickle cell disease (SCD) is associated with chronic haemolysis, immuno-suppression and suscepti- bility to infections, which may trigger infection-associated haemolysis (IAH). (bvsalud.org)

This represents a cancer that does not respond to most available treatments and usually escapes adjuvant therapy. (ijpsonline.com)
Understanding the unique chemistry between drugs, viruses, and host cells is essential for developing more effective and safe antiviral treatments. (chayadeep.com)
Antiviral immune responses present a major hurdle to the efficacious use of oncolytic adenoviruses as cancer treatments. (aacrjournals.org)

By bringing T cells near cancer cells, the T cells can inject toxins and trigger cancer cell death (apoptosis). (gurufocus.com)
An induced state of non-reactivity to grafted tissue from a donor organism that would ordinarily trigger a cell-mediated or humoral immune response. (lookformedical.com)

In murine plasmacytoma versions vaccination with DCs fused with mouse 4TOO plasmacytoma cells 44 or J558 myeloma YIL 781 cells 45 was connected with induction of anti-tumor humoral and CTL replies. (tech-strategy.org)
Solanum nigrum (SN) is a herb with anticancer effects such as destruction of tumor cell membrane, induction of apoptosis by NF-kappaB, caspase activation, nitric oxide production and inhibition of angiogenesis [ 3 ]. (ijpsonline.com)
Quercetin enhances susceptibility to NK cell-mediated lysis of tumor cells through induction of NKG2D ligands and suppression of HSP70. (imuno-medica.ro)

It may also be called a nitrogen mustard derivative or a cytotoxic agent. (drugs.com)

The reciprocal relationship between HSCs and precancerous hepatocytes or hepatoma cells promotes tumorigenesis, migration and invasion of cancer cells, and formation of metastasis ( 11 ). (spandidos-publications.com)

One key factor is the drug's specificity in interacting with host cells. (chayadeep.com)

Approximately 80-90% of newly diagnosed lung cancers are classified as NSCLC, primarily consisting of adenocarcinoma, squamous cell carcinoma, or large cell carcinoma histologies. (frontiersin.org)
The relatively avascular epidermis houses both basal cell keratinocytes and squamous epithelial keratinocytes, the source cells for basal cell carcinoma and squamous cell carcinoma, respectively. (cancer.gov)

Typically, CARs consist of a target binding domain, which is an extracellular domain that is specifically expressed by CAR-T cells, a transmembrane domain, and a signalling domain, which is an intracellular domain that provides an activation signal to T cells. (nature.com)
Increased drug efflux, via these transporters, lowers intracellular drug concentration, allowing cancer cells to escape the toxic effects of the drugs. (savedelicious.com)

However, the role of C1QBP in metabolism, oxidative stress, and apoptosis of renal cell carcinoma (RCC) cells have not yet been explored. (medsci.org)
Renal cell carcinoma is one of the most common cancers in the urinary system, causing over 140,000 deaths worldwide each year[ 1 ]. (medsci.org)

Quercetin is an important natural and non-invasive anticancer agent, beneficial in preventing and treating cancer. (imuno-medica.ro)

In fungi, ozone inhibits cell growth at certain stages. (silvermedicine.org)
By xenografting human breast cancer cells into nude mice, we found that VALD-3 significantly suppressed tumor cell growth while showing low toxicity against major organs. (researchsquare.com)
This slows the growth of cancer cells in the body. (drugs.com)
It works by slowing or stopping the growth of the cancer cells. (mrmed.in)
Proteasomes play an important role in controlling cell function and growth. (medicines.org.uk)
T cell growth factor [i.e. (humankinetics.com)
CRC cell growth induced by C. tropicalis is partially offset in the presence of PD-1 overexpression. (jcancer.org)

This mode of action is being referred to as BiTE for "bispecific T-cell engager" technology. (aacrjournals.org)

In addition, ozone oxidizes the outer lipid layer of malignant cells and destroys them through cell lysis (break- down). (silvermedicine.org)
BiTE molecules fight cancer by helping the body's immune system detect and target malignant cells by engaging T cells (a type of white blood cell capable of killing other cells perceived as threats) to cancer cells. (gurufocus.com)

One hundred years ago, lung cancer was a rare malignancy ( 1 ). (frontiersin.org)
Lung cancer today is the leading cause of cancer death in the United States, with over 158,000 estimated deaths in 2016 ( 2 ). (frontiersin.org)
TNM staging was introduced in 1974 and it helped shape the way lung cancer was managed. (frontiersin.org)

These actions block DNA synthesis, causing a block at G2 phase and subsequently apoptotic cell death. (savedelicious.com)
Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. (lookformedical.com)

These methods and results can help us to better understand immune reconstitution following hematopoietic cell transplantation, leading to future studies on the clinical application of adoptive T-cell therapies. (nature.com)
The specific medications administered depend on the choice of therapy and whether it is supportive care only, immunosuppressive therapy, or hematopoietic cell transplantation. (medscape.com)
Central venous catheter placement is required before the administration of hematopoietic cell transplantation. (medscape.com)

Replication-competent viruses, also known as oncolytic viruses, replicate within transduced cells and force these cells into a lytic cycle. (hindawi.com)

A previous study reported that the extract of the whole plant of SN activated cell death in hepatoma cells through autophagy and apoptosis [ 7 ]. (ijpsonline.com)

Anatomy31

Organisms16

Diseases19

Chemicals and Drugs95

Analytical, Diagnostic and Therapeutic Techniques and Equipment34

Phenomena and Processes61

Disciplines and Occupations1

Information Science3

Health Care1

Chemotherapy19

Signaling molecules1

Proliferation19

Lymphocytes3

Flow cytometry3

Immunotherapy11

Vitro9

Induces5

Autologous6

Antitumor1

Inhibit3

Efficacy5

Apoptotic effects1

Tumor growth4

Resistance5

Selectively1

Types of cancers2

Immune cells6

Bone marrow8

Assays6

Monoclonal2

Treatment40

Viability1

Receptors3

Antigens4

Tumour6

Vivo7

Survival7

Receptor6

Effector3

Melanoma8

Proteins8

Phenotype1

Mechanisms of act2

Genes1

Antibodies6

Targets2

Colorectal cancer3

Phagocytes1

20221

Liver cancer1

Cytotoxicity2

Metastatic5

Dendritic cells2

CTLs2

Protein4

Activity5

Allogeneic3

Lymphocyte1

Apoptosis and cell1

Cutaneous squamous-cell carc2

Arrest2

Infections6

Treatments3

Trigger2

Induction3

Derivative1

Metastasis1

Specificity1

Squamous2

Intracellular2

Renal cell carc2

Anticancer1

Growth7

Bispecific1

Malignant cells2

Lung cancer3

Synthesis2

Transplantation3

Oncolytic1

Hepatoma cells1