• Some of the new approaches depend on tumor biology and aim specifically to inhibit tumor growth and metastasis by targeting the tumor microenvironment or vasculature (leaving normal cells unaffected) or focusing on specific protein or signal transduction pathways. (medscape.com)
  • The former include hypoxia, high lactate levels or the abundance of growth factors within the cellular microenvironment. (springer.com)
  • Pro-growth signals from the tumor microenvironment, as well as the cell-intrinsic response to radiation therapy, drove the mesenchymal shift through a stress-response pathway mediated by AP1. (ucsf.edu)
  • Cancer-associated fibroblasts (CAFs) are a major cellular component of tumor microenvironment in most solid cancers. (elifesciences.org)
  • Cancer stem cells (CSCs) are generated by a combination of DNA mutations, epigenetic events, and tissue microenvironment factors from normal stem cells or precursor/progenitor cells, to which they are closely related and share many of the behaviors and features 1 . (atlasantibodies.com)
  • Cancer cells obtain a growth advantage through uncontrolled cell proliferation ( Hanahan and Weinberg, 2011 ), which may be caused by mutations that help them adapt to the microenvironment through selective pressure. (molcells.org)
  • The module will include the importance of cancer stem cells and the tumour microenvironment, the spread of cancer and therapeutic advances. (york.ac.uk)
  • Epigenetic mechanisms play important roles in the regulation of tumorigenesis, and hypoxia-induced epigenetic changes may be key drivers of the adaptation of cancer cells to the hypoxic microenvironment typical of solid tumors. (nih.gov)
  • While some patients experience spontaneous regression or differentiation of the tumor, others are affected by rapid and fatal tumor progression despite increasingly intensive treatment strategies [ 9 ]. (biomedcentral.com)
  • Here, cycles of fasting for 2 days in the absence of other treatments are shown to delay the progression of several tumor types in mice and, in some cases, to be as effective as toxic chemotherapy drugs. (kingdomfasting.com)
  • However, the combination of fasting and chemotherapy was much more effective than either alone and delayed the progression of a variety of tumors, including breast cancer and glioma, reduced the number of organs affected by melanoma metastases, and promoted long-term cancer-free survival in up to 40% of mice with neuroblastomas. (kingdomfasting.com)
  • In mice injected with human breast and ovarian cancer cells, fasting cycles promoted survival extension by protecting the mice from chemotherapy while causing a strong inhibition of tumor progression. (kingdomfasting.com)
  • Cycles of starvation were as effective as chemotherapeutic agents in delaying progression of different tumors and increased the effectiveness of these drugs against melanoma, glioma, and breast cancer cells. (kingdomfasting.com)
  • Also, DR only retards the progression of specific cancers, possibly because of its relatively small effect on glucose and growth factors (7, 8). (kingdomfasting.com)
  • This effect is mediated by downregulation of the key cell cycle progression factors cyclin B1, cyclin D1, CDK1, CDK4, and survivin, the latter also constituting an essential inhibitor of apoptosis, underlying additionally the onset of apoptosis. (uandes.cl)
  • A vast amount of research exists on the possible molecular mechanisms through which vitamin D affects cancer cell proliferation, cancer progression, angiogenesis, and inflammation. (mdpi.com)
  • Cell cycle analysis suggested activation of apoptosis, without arresting cell cycle progression. (nature.com)
  • Angiogenesis is essential in the process of carcinogenesis to facilitate tumor progression and metastasis. (spandidos-publications.com)
  • Another important mechanism for the progression of colorectal cancer is the ability of the transformed cells to invade and traverse the basement membrane, which in turn facilitates the conversion of adenomas into carcinomas and then metastases ( 1 ). (spandidos-publications.com)
  • Aggressive tumors typically demonstrate a high glycolytic rate, which results in resistance to radiation therapy and cancer progression via several molecular and physiologic mechanisms. (springer.com)
  • Furthermore, poorer prognosis in cancer patients who display a glycolytic phenotype characterized by metabolic alterations, such as obesity and diabetes, is now well established, providing another link between metabolic pathways and cancer progression. (springer.com)
  • The study identified 2 genes known to contribute to tumor progression and 8 known to be present in tumor cells but which have unknown functions. (frontiersin.org)
  • Together, these results indicate epigenetic loss of BCO2 expression is associated with prostate cancer progression. (nih.gov)
  • In cancer progression, FOXO3a inhibition stimulates cell transformation and angiogenesis ( 9 ). (spandidos-publications.com)
  • Moreover, TSPAN12 accelerated mitotic progression by controlling cell cycle. (molcells.org)
  • We will discuss the key features of cancer biology, such as deregulated cell cycle progression, growth, invasion and metastasis. (york.ac.uk)
  • Propidium iodide staining and flow cytometry analysis of Annexin V binding was utilized to measure the progression of the cell cycle and the induction of apoptosis. (techscience.com)
  • Hence, many effects of nutrition on the development and progression of cancer lack 'specificity' in their association, and such alimentary cues also affect the risk of developing metabolic syndrome, a prelude to arteriosclerosis and neurodegeneration ( Fig. 1 ). (nature.com)
  • The triangle composed of nutrition, inflammation and immunity, and cancer illustrates how qualitative and quantitative imbalances in food intake predispose organisms, in a manner dependent on or independent of the immune system, to a time-dependent deterioration in function that culminates in the development and progression of cancer. (nature.com)
  • T he presence and activity of various proteins are required in the cell cycle progression. (ukessays.com)
  • Research published in June 2013 by researchers from the University of South Florida and Boston College using mice models reported that a "Ketogenic Diet alone significantly decreased blood glucose, slowed tumor progression and increased mean survival time by 56.7% in mice with systemic metastatic cancer. (drsircus.com)
  • While Hyperbaric Oxygen Therapy alone did not influence cancer progression, combining the Ketogenic Diet with Hyperbaric Oxygen elicited a significant decrease in blood glucose, tumor growth rate and a 77% increase in mean survival times compared to the controls. (drsircus.com)
  • This specific project aims to identify sequences within caveolin involved in regulation of raft internalisation, cell cycle progression and anchorage-dependent cell growth. (europa.eu)
  • This objective integrates into a bigger project that also aims to identify molecular mechanisms by which caveolin regulates anchorage-dependent signalling pathways and cell cycle progression and to identify oncogenes that induce constitutive surface localization of rafts (and hence Rac), and/or changes in phosphocaveolin localization. (europa.eu)
  • The presence of metastatic disease in 15% of the MCA/MWCNTexposed mice compared to 1.6% in the MCA-exposed group suggests that carbon nanotube s also induce cancer progression. (cdc.gov)
  • The presentation will include a discussion of the mechanism of MWCNT-induced tumor promotion and progression as well as work in progress to examine the dose response of MWCNT-induced tumor promotion. (cdc.gov)
  • Most patients have tumor metastasis and recurrence within 2 years, and the 5-year survival rate is 20%-40% [ 2 ]. (hindawi.com)
  • Additionally, the expression and activity of matrix metalloproteinases (MMPs) are increased in almost every type of human cancer, which may be associated with cell invasion, metastasis and angiogenesis. (spandidos-publications.com)
  • MMPs have been implicated in these processes and a previous study has suggested that the plasma level of MMP-2 and MMP-9 may be viewed as a non-invasive indicator of invasiveness and metastasis in colon cancer ( 3 ). (spandidos-publications.com)
  • Cancer cells that die via apoptosis (larger dark purple structures) expel their nuclear contents (orange and yellow stringy structures) to spur metastasis and growth of living cancer cells (smaller light blue structures). (cancer.gov)
  • Cancer stem cells (CSCs) are small cells, 1% to 3% of all cells in a tumor, that drive the tumor's initiation, growth, and metastasis and may cause relapse. (atlasantibodies.com)
  • It also suppresses the receptor of the epidermal growth factor called EGFR/HER2 and its signalling pathways, which could be an attractive target in cancer therapies because of their important role in the processes of cell survival and proliferation, as well as in those of apoptosis and metastasis. (agenciasinc.es)
  • Here, we determined that upregulation of the oncogenic transcriptional coregulator steroid receptor coactivator 2 (SRC-2), also known as NCOA2, drives glutamine-dependent de novo lipogenesis, which supports tumor cell survival and eventual metastasis. (jci.org)
  • Metabolic profiling of human prostate tumors identified a massive increase in the SRC-2-driven metabolic signature in metastatic tumors compared with that seen in localized tumors, further implicating SRC-2 as a prominent metabolic coordinator of cancer metastasis. (jci.org)
  • Moreover, SRC-2 inhibition in murine models severely attenuated the survival, growth, and metastasis of prostate cancer. (jci.org)
  • Some tumor suppressor proteins are involved in maintaining cell adhesion, preventing cells from breaking away and spreading to other parts of the body (metastasis). (pharmiweb.com)
  • Dysregulation of these molecules can lead to various diseases, including cancer metastasis, autoimmune disorders, and developmental abnormalities. (pharmiweb.com)
  • Overall, only about 33% of Hürthle cell tumors demonstrate signs of that invasive growth that indicates malignancy and the possibility of metastasis. (medscape.com)
  • Apoptosis protects the body by removing genetically damaged cells that could lead to cancer, and it plays an important role in the development of the embryo and the maintenance of adult tissues. (medlineplus.gov)
  • Studies have found that E2F1 is highly expressed in a variety of tumor tissues and cells and plays a role of oncogenic gene [ 10 - 13 ]. (hindawi.com)
  • Such phytochemicals can block the action of carcinogens on target tissues thereby suppressing cancer development. (nature.com)
  • The tumor size and the number of proliferating cells were reduced in the tumor tissues obtained from the formononetin-treated group. (spandidos-publications.com)
  • When applied to cancer research, microarray technology typically measures gene expressions of cancer and normal tissues or different types of cancer. (hindawi.com)
  • In obese humans, adipocyte-secreted CCL20 may contribute to the deposition of Compact disc4+ helper and Compact disc8+ cytotoxic T lymphocytes within adipose tissues, possibly via connections with CCR6 which was upregulated on T cells in obese adipose tissues (100). (exposed-skin-care.net)
  • However, the main element substances that mediate T cell infiltration into adipose tissues in maturing remain to become discovered. (exposed-skin-care.net)
  • Activation of Typical T Cells in Adipose Tissues Compact disc4+ Purpureaside C T Cell Activation TCRs recognize the current presence of a particular antigen by binding to brief peptide sequences in the antigen that's shown on APCs. (exposed-skin-care.net)
  • further defined that mostly huge adipocytes from obese adipose tissues exhibited an increased expression degree of MHCII substances and acted as APCs to activate Compact disc4+ T cells to secrete IFN- (103). (exposed-skin-care.net)
  • Among all cancerous cells, a few act as stem cells that reproduce and sustain the tumor, much like stem cells normally renew and sustain our organs and tissues. (atlasantibodies.com)
  • Hematological cancers (blood cancers) arise in the blood-forming tissues, such as bone marrow, lymph nodes, and lymphatic system. (atlasantibodies.com)
  • Here, we reported that mammalian target of rapamycin complex 2 (mTORC2) kinase is overexpressed in pancreatic cancer tissues and promotes pancreatic cancer cell growth and invasion. (techscience.com)
  • Evidence leads us to believe that tumors of non-hepatic tissues may be unable to metabolize ketone-bodies and suggest a therapeutic strategy for selective starvation of tumors by dietary modification. (drsircus.com)
  • They facilitate adhesion between leukocytes and endothelial cells, enabling leukocyte extravasation into tissues during inflammation. (pharmiweb.com)
  • Ig-superfamily CADMs are involved in mediating cell-to-cell adhesion, helping cells stick together and form tissues and organs. (pharmiweb.com)
  • Chronic Granulomatous Disease , autoimmune diseases Autoimmune diseases Disorders that are characterized by the production of antibodies that react with host tissues or immune effector cells that are autoreactive to endogenous peptides. (lecturio.com)
  • BZD also increases the ratio of CD4+ T cells to CD8+ T cells in the spleen and tumor tissues, boosting IFN-γ expression, essential for anti-tumor immunity. (bvsalud.org)
  • As proof-of-concept, we show that in vivo knockdown of ASncmtRNAs results in drastic inhibition of tumor growth in a xenograft model of MDA-MB-231 subcutaneous tumors, further supporting this approach for the development of new therapeutic strategies against breast cancer. (uandes.cl)
  • More importantly, we show that MESF treatment leads to significant inhibition of tumor growth and a 3-fold increase in the life span of tumor bearing animals compared to untreated tumor mice. (nature.com)
  • Our objective was to evaluate the effect of the COX-2 inhibitor, celecoxib, on (1) proliferation and apoptosis in human ovarian cancer cell lines and primary cultures of ovarian cancer cells, and (2) inhibition of tumor growth in a genetically engineered mouse model of serous ovarian cancer under obese and non-obese conditions. (houstonmethodist.org)
  • Chloro ethyl nitroso urea (CENU), specifically carmustine (BCNU), are crosslinking agents that are widely used in chemotherapy, particularly for brain tumors. (wikipedia.org)
  • Glioblastomas (GBMs) are incurable brain tumors with a prognosis of about one-and-a half years on average. (ucsf.edu)
  • On the other hand, in brain tumors, such as glioma and glioblastoma, CSCs have instead been identified using cell surface markers, including SSEA-1 20 , EGFR 21 , and CD44 22 . (atlasantibodies.com)
  • We investigated by real-time quantitative RT-PCR the expression profile of a panel of genes important in cell cycle regulation. (biomedcentral.com)
  • Interestingly, the 1p36 region is frequently deleted not only in NB, but also in other human cancer types, including those of neural, epithelial and hematopoietic origin, indicating that the same tumor suppressor genes might be involved in a broad range of human cancers [ 11 ]. (biomedcentral.com)
  • How do genes control the growth and division of cells? (medlineplus.gov)
  • A variety of genes are involved in the control of cell growth and division. (medlineplus.gov)
  • The cell cycle has checkpoints (also called restriction points), which allow certain genes to check for problems and halt the cycle for repairs if something goes wrong. (medlineplus.gov)
  • This task can be accomplished by replacing tumor suppressor genes that have been lost or mutated, selectively inserting genes that produce cytotoxic substances, or modifying the immune system to destroy the tumor cells. (medscape.com)
  • Previous applications of microarray technology for cancer research have mostly focused on identifying genes that are differentially expressed between a particular cancer and normal cells. (hindawi.com)
  • Therefore, it is critical to understand the relationship (e.g., interactions) between genes across different types of cancer in order to gain insights into the molecular mechanisms of cancer. (hindawi.com)
  • Microarray technology, monitoring mRNA abundance of tens of thousands of genes simultaneously, provides an efficient tool to characterize a cell at the molecular level. (hindawi.com)
  • One important area in microarray-based cancer research is to identify genes that are differentially expressed between cancerous and normal cells and to discover diagnostic and prognostic signatures in order to predict therapeutic responses. (hindawi.com)
  • However, the simple list of individual differentially expressed genes can only tell us which genes are altered by biological differences between different cell types and/or states. (hindawi.com)
  • Since the identification of biological pathways is significantly influenced by those differentially expressed genes from different datasets or different statistical methods [ 16 , 17 ], we reason here that an integration of multiple cancer microarray datasets and identification of the most common pathways from these data would reveal key relationships between crucial genes in carcinogenesis. (hindawi.com)
  • Our focus on the interactions and pathways of cancer-related genes is important since changes in gene relations and key pathways are more relevant to carcinogenesis than individual genes alone. (hindawi.com)
  • identified 189 frequently mutated genes associated with these cancers, most of which were not previously known. (frontiersin.org)
  • These genes encode proteins involved in DNA replication and cell cycle/proliferation that contribute to major pathways responsible for suppression of colorectal carcinogenesis pathways. (iiarjournals.org)
  • Conclusion: SCFAs inhibited the expression of genes encoding proteins involved in DNA replication and cell cycle/proliferation of human colorectal cancer cells and exerted antiproliferative activity via different pathways. (iiarjournals.org)
  • Treatment with honey stops the tumour cells cycle by regulating some genes (cyclin D1, CDK2, p27Kip. (agenciasinc.es)
  • it inhibits cell migration, reduces the ability to form colonies and induces apoptosis or programmed cell death through the modulation of other key genes (p53, caspase-3, c-PARP) and various apoptotic factors," says Maurizio Battino, coordinator of the research. (agenciasinc.es)
  • 1) The alternation of protein levels of critical oncogenes or tumour suppressor genes, which causes by miRNAs deregulation may also lead to proliferative diseases such as cancer. (ukessays.com)
  • Besides cancer, some miRNAs genes cause or contribute in many inherited and genetic based diseases. (ukessays.com)
  • These 12 genes are located at a region, which is frequently deleted in cancer. (ukessays.com)
  • Tumor suppressor genes code for proteins that inhibit cell division and growth, acting as a control mechanism to prevent excessive cell proliferation. (pharmiweb.com)
  • Tumor suppressor genes can promote cellular senescence, a state in which cells stop dividing, preventing the replication of damaged DNA. (pharmiweb.com)
  • Interestingly, whole transcriptome analysis revealed that a number of previously non-responsive genes become amenable to hypoxia following G9A inhibition, including many targets that drive cancer cell survival. (nih.gov)
  • The total chromosomal content of a cell involves approximately 105 genes in a specialized macromolecule of deoxyribonucleic acid (DNA). (cdc.gov)
  • The first solid tumor exomes to be investigated were from 11 breast and 11 colorectal cancer tissue samples. (frontiersin.org)
  • Both experience high rates of lung and colorectal cancer. (healthandenvironment.org)
  • Background/Aim: Short-chain fatty acids (SCFAs) inhibit human colorectal cancer cell growth and tumorigenicity. (iiarjournals.org)
  • We investigated the mechanism of the anti-proliferative effects of SCFAs on human colorectal cancer cells by examining their effects on gene expression. (iiarjournals.org)
  • The consumption of probiotics has attracted attention for the maintenance of health and the prevention of diseases, such as colorectal cancer or hepatocellular carcinoma ( 1 - 3 ). (iiarjournals.org)
  • We previously found that SCFAs, such as butyric acid, isobutyric acid and acetic acid, inhibit the growth of cultured human colorectal cancer cells and that butyric acid is the strongest inhibitor ( 3 ). (iiarjournals.org)
  • With these data it is not yet possible to speak of a cure or safe prevention of colorectal cancer thanks to strawberry tree honey," emphasizes Battino, who adds: "This work constitutes a starting point in the effort to evaluate its possible biological and anti-cancer effects and indicates the main molecular mechanisms through which it exerts its effect, reinforcing the interest in the study and production of this Mediterranean foodstuff. (agenciasinc.es)
  • Objective: Bazhen Decoction (BZD) is a common adjuvant therapy drug for colorectal cancer (CRC), although its anti-tumor mechanism is unknown. (bvsalud.org)
  • Cell and animal research confirmed Bazhen Decoction efficacy and mechanism in treating colorectal cancer. (bvsalud.org)
  • Furthermore, BZD can increase the number of T cells and promote T cell activation in tumor-bearing mice, enhancing the immune function against colorectal cancer. (bvsalud.org)
  • Among them, quercetin, kaempferol, licochalcone A, naringenin, and formaronetin are more highly predictive components related to the T cell activation in colorectal cancer mice. (bvsalud.org)
  • Targeted molecular therapy against EGFR has shown promise as an adjuvant therapy in preliminary studies in several solid tumors, including head and neck cancer. (medscape.com)
  • Expression of the bco2 gene is dramatically decreased in prostate cancer tissue and in a range of prostate cancer cell lines as compared with nonneoplastic prostate tissue and normal prostatic epithelial cells, respectively. (nih.gov)
  • It is involved in the proliferation, invasion, apoptosis and epithelial mesenchymal transformation of malignant tumor cells. (techscience.com)
  • Epithelial carcinoma makes up 85% to 90% of ovarian/fallopian tube cancers. (cancer.net)
  • SRC-2 was highly elevated in a variety of tumors, especially in prostate cancer, in which SRC-2 was amplified and overexpressed in 37% of the metastatic tumors evaluated. (jci.org)
  • These adducts interfere with cellular metabolism, such as DNA replication and transcription, triggering cell death. (wikipedia.org)
  • Endogenous crosslinking agents are compounds and metabolites that are introduced from cellular or biochemical pathways within a cell or organism. (wikipedia.org)
  • The cell is, in fact, committing cellular suicide. (sciencedaily.com)
  • This was the first time that researchers were able to comprehensively map intra-cellular signaling in the tumor-anatomical niches of recurrent GBM and identify novel cell-extrinsic therapeutic targets. (ucsf.edu)
  • The 86 specimens contained the cellular tumor and adjacent non-malignant tissue from the surgical margin. (ucsf.edu)
  • Altered cellular metabolism is a hallmark of cancer, and much of the published literature has focused on neoplastic cell-autonomous processes for these adaptations. (elifesciences.org)
  • FOXO3a is considered an evolutionarily conserved transcription factor involved in various cellular processes, including cell cycle arrest, DNA repair and tumor suppression ( 8 ). (spandidos-publications.com)
  • The transforming gene products of these viruses, such as the E1A oncoproteins of adenovirus 5, led to the identification of cellular factor p60, known as cyclin A. This research was the first demonstration of a physical link between cellular transformation and the cell cycle, thereby paving the way for the melding of these two areas of research. (newswise.com)
  • Of note, an increased carbohydrate uptake and/or induction of death receptors of cancer cells was exploited to develop glycoconjugates that potentially induce cellular stress, ROS and apoptosis. (degruyter.com)
  • Redirection of glutamine to cellular energetics destabilizes glutathione homeostasis in glioblastoma cells and other cancer cells [ 9 ]. (degruyter.com)
  • The cellular and molecular abnormalities of cancer will be analyzed and the latest theraputic advances. (york.ac.uk)
  • This module will review current knowledge, underpinning principles and recurrent themes in the molecular and cellular biology of cancer. (york.ac.uk)
  • 2. Discuss the molecular and cellular basis of cancer. (york.ac.uk)
  • Treatment with celecoxib resulted in G1 cell cycle arrest, induction of apoptosis, inhibition of cellular adhesion and invasion and reduction of expression of hTERT mRNA and COX- 2 protein in all of the ovarian cancer cell lines. (houstonmethodist.org)
  • [ 2 ] Oncocytic cells in the thyroid are often called Hürthle cells, and oncocytic change is defined as cellular enlargement characterized by an abundant eosinophilic granular cytoplasm as a result of accumulation of altered mitochondria. (medscape.com)
  • The protein is involved in cellular growth and development and has an important role in regulating the cell cycle. (msdmanuals.com)
  • A very large radiation dose received in a short enough period of time to preclude significant repair can cause cellular walls to collapse and disrupt organ systems, producing deterministic effects such as acute radiation syndrome, cataracts, and teratogenesis (mental retardation, IQ reduction, microencephaly, stunted growth). (cdc.gov)
  • Specialized cell structures called ribosomes are the cellular organelles that actually synthesize the proteins (RNA transcription). (cdc.gov)
  • In mouse models of neuroblastoma, fasting cycles plus chemotherapy drugs-but not either treatment alone-resulted in long-term cancer-free survival. (kingdomfasting.com)
  • Currently, its standard treatment includes surgery and platinum chemotherapy, but most patients will relapse within 16-22 months due to drug resistance and other factors, and the 5-year survival rate of ovarian cancer is only 46% [ 6 ]. (hindawi.com)
  • New study finds that short fasting cycles can work as well as chemotherapy, and the two combined greatly improve survival. (sciencedaily.com)
  • Fasting also extended survival in mice bearing a human ovarian cancer. (sciencedaily.com)
  • For all cancers tested, fasting combined with chemotherapy improved survival, slowed tumor growth and/or limited the spread of tumors. (sciencedaily.com)
  • The growth of large tumor masses was reduced by multiple fasting and chemotherapy cycles, but cancer-free survival could not be achieved. (sciencedaily.com)
  • The HER (erbB) family of transmembrane receptor tyrosine kinases is one of the cytostatic targets in tumor cell growth and survival. (medscape.com)
  • Thus, selectively targeting CSCs with specific antibodies holds hope for improving cancer patients' survival and is a promising therapeutic strategy against cancer. (atlasantibodies.com)
  • In this study, The Cancer Genome Atlas (TCGA) dataset analysis revealed that upregulation of TSPAN12 gene expression was significantly correlated with patient survival, suggesting that TSPAN12 might be a potential prognostic marker for OC. (molcells.org)
  • Most cancer cells undergo metabolic reprogramming that support their survival and proliferation. (degruyter.com)
  • This indicates the intricate control of metabolism and redox balance for survival of cancer cells that can be targeted by therapeutic agents. (degruyter.com)
  • Abstract Pancreatic cancer is one of the most aggressive cancers with a median survival time of less than 5 months, and conventional chemotherapeutics are the main treatment strategy. (techscience.com)
  • Metabolic pathway reprogramming is a hallmark of cancer cell growth and survival and supports the anabolic and energetic demands of these rapidly dividing cells. (jci.org)
  • However, cancer cells mount a survival response via activation of the HIF pathway that may necessitate the additional suppression of HIF signaling for improved efficacy in the eradication of the disease. (nih.gov)
  • Despite methodological differences, findings evidence that although IBC presents particular features (lower survival rate and worse prognostics than most types of breast cancer), very few studies examine its epidemiology and specific risk factors in depth and use any other therapeutic approaches than those commonly used for other breast cancer subtypes. (bvsalud.org)
  • With an average survival rate of three years, IBC accounts for about 2.5% of all breast cancer types in the US. (bvsalud.org)
  • Therefore, improving the early diagnosis rate, chemotherapy drug sensitivity, reducing tumor recurrence, and improving disease prognosis are the focus of diagnosis and treatment research at the present stage [ 8 , 9 ]. (hindawi.com)
  • In this study, we investigated how TSPAN12 regulates OC cell proliferation both in vitro and in vivo and found that it contributed to tumor proliferation and poor prognosis in this disease through cyclin and cyclin-dependent kinase (CDK) pathways. (molcells.org)
  • Here, we show that G9A is highly expressed in breast cancer compared to normal breast tissue and is associated with poor prognosis in patients, where it may function as a potent oncogenic driver in this cancer type. (nih.gov)
  • Myc) and tumour suppressors (e.g. p53). (york.ac.uk)
  • These are divided into two group, those miRNAs that are upregulated in cancer which are likely to be acting as oncogenes and those downregulated in cancer which are likely to be acting as tumour suppressors. (ukessays.com)
  • Tumor suppressors are involved in regulating the cell cycle, ensuring that cells only divide when necessary and that the process is tightly controlled. (pharmiweb.com)
  • Although clinical trials testing the effect of fasting in cancer treatment are still in the early stages, they suggest that fasting cycles may boost the efficacy of chemotherapeutic agents and could be as effective as chemotherapy drugs in the killing of specific tumor cells. (kingdomfasting.com)
  • Short-term starvation (or fasting) protects normal cells, mice, and potentially humans from the harmful side effects of a variety of chemotherapy drugs. (kingdomfasting.com)
  • These studies suggest that multiple cycles of fasting promote differential stress sensitization in a wide range of tumors and could potentially replace or augment the efficacy of certain chemotherapy drugs in the treatment of various cancers. (kingdomfasting.com)
  • However, DR is not feasible for patients already prone to weight loss from the cancer itself or from the chemotherapy, because, based on animal studies, several months may be necessary for patients undergoing DR to reach a protected state. (kingdomfasting.com)
  • Finally, it is not known whether DR would also protect cancer cells from chemotherapy. (kingdomfasting.com)
  • DNA crosslinking also has useful merit in chemotherapy and targeting cancerous cells for apoptosis, as well as in understanding how proteins interact with DNA. (wikipedia.org)
  • Similar to nitrogen mustards, cisplatin is used frequently in chemotherapy treatment - especially for testicular and ovarian cancers. (wikipedia.org)
  • Mitomycin C (MMC) is from a class of antibiotics that are used broadly in chemotherapy, often with gastrointestinal related cancers. (wikipedia.org)
  • Due to the large tumor load in advanced patients, drug resistance is easy to occur during chemotherapy. (hindawi.com)
  • Man may not live by bread alone, but cancer in animals appears less resilient, according to a study that found chemotherapy drugs work better when combined with cycles of short, severe fasting. (sciencedaily.com)
  • The study in Science Translational Medicine , part of the Science family of journals, found that five out of eight cancer types in mice responded to fasting alone: Just as with chemotherapy, fasting slowed the growth and spread of tumors. (sciencedaily.com)
  • And without exception, "the combination of fasting cycles plus chemotherapy was either more or much more effective than chemo alone," said senior author Valter Longo, professor of gerontology and biological sciences at the University of Southern California. (sciencedaily.com)
  • For example, multiple cycles of fasting combined with chemotherapy cured 20 percent of mice with a highly aggressive type of children's cancer that had spread throughout the organism and 40 percent of mice with a more limited spread of the same cancer. (sciencedaily.com)
  • In a case report study with self-reported data published in the journal Aging in 2010, 10 cancer patients who tried fasting cycles perceived fewer side effects from chemotherapy. (sciencedaily.com)
  • In mice, the study found that fasting cycles without chemotherapy could slow the growth of breast cancer, melanoma, glioma and human neuroblastoma. (sciencedaily.com)
  • In several cases, the fasting cycles were as effective as chemotherapy. (sciencedaily.com)
  • In the case of melanoma, the cancer cells became resistant to fasting alone after a single round, but the single cycle of fasting was as effective as chemotherapy in reducing the spread of cancer to other organs. (sciencedaily.com)
  • Targeted molecular therapy, like therapy with monoclonal antibodies, gene therapy, and other therapies, has limited or nonexistent side effects on normal cells of the body, unlike present modalities such as surgery, chemotherapy, and radiotherapy. (medscape.com)
  • Today, it constitutes the standard of care for many cancer patients, along with surgery and chemotherapy. (springer.com)
  • So too can cancer treatments like radiation and chemotherapy. (cancer.gov)
  • Other side-effects of the current chemotherapy treatment of patients with cervical cancer are fatigue, nausea, vomiting, and diarrhea ( 11 ). (iiarjournals.org)
  • Preclinical assays show that systemic administration of ASO delayed tumor growth in melanoma and renal cancer models and, caused total remission in subcutaneous renal cancer tumors. (intechopen.com)
  • 14 Cancers increasing in the US include lung cancer (especially in women), melanoma, non-Hodgkin lymphoma and myeloma. (healthandenvironment.org)
  • Apoptotic death is preceded by proliferation blockage, suggesting that these transcripts are involved in cell cycle regulation. (uandes.cl)
  • Tight regulation of this process ensures that a dividing cell's DNA is copied properly, any errors in the DNA are repaired, and each daughter cell receives a full set of chromosomes. (medlineplus.gov)
  • Disruption of normal regulation of the cell cycle can lead to diseases such as cancer. (medlineplus.gov)
  • The main reason is that the regulation mechanism of the tumor cell cycle is damaged, which leads to uncontrolled cell growth. (hindawi.com)
  • It also helped to open a very exciting avenue of research involving investigators with expertise in different aspects of growth control and cancer.Giordano's lab also discovered the tumor suppressor gene RB2/p130 and the cell cycle kinases CDK9 and CDK10, two other key players in cell cycle regulation and cell differentiation. (newswise.com)
  • Cyclin A2, Cyclin D1, Cyclin E2, CDK2, and CDK4) were significantly involved in the regulation of cell cycle downstream of TSPAN12. (molcells.org)
  • 1) The regulation of these protein levels is vital for the understanding of the cell cycle control and its dysregulation. (ukessays.com)
  • 1) For example, the down-regulation of miR15s and miR - 16 - 1 in chronic lymphocytic leukaemia, prostate cancer and pituitary tumours, leading to the inhibition of tumour growth and induce cell cycle arrest at the G 1 - phase by target cell cycle regulators ( cyclin D1, cyclin E1, cyclin D3 and CDK6). (ukessays.com)
  • Therefore, a therapeutic strategy targeting CSCs may help cure malignant tumors, including SCLC ( 7 ). (spandidos-publications.com)
  • Malignant tumors are noted by adding "sarcoma" or "carcinoma. (healthandenvironment.org)
  • Permissive histologic interpretation may result in the designation of some non-neoplastic Hürthle cell lesions as malignant tumors. (medscape.com)
  • The reduction in tumor volume as well as pro-apoptotic and anti-proliferative effects in HT-29 nude mice xenograft are comparable to those produced by 5-FU. (spandidos-publications.com)
  • Therefore we investigated the antitumor effects of DMC on a HeLa cell xenograft model in nude mice in this study. (iiarjournals.org)
  • Results: DMC significantly reduced tumor weights and volumes of HeLa cell xenografts in mice, indicating the suppression of growth of xenograft tumors. (iiarjournals.org)
  • They found that cells in this surgical margin acted as niches of recurrence where non-malignant glia were broadcasting pro-growth signals that influenced the tumor cells to regrow. (ucsf.edu)
  • These paracrine (cell extrinsic) signals stimulated the activator protein (AP1) pathway, leading to mesenchymal transition, therapy resistance and tumor recurrence. (ucsf.edu)
  • Casticin, a natural polymethoxyflavone isolated from A. annua, V. trifolia, and V. agnus‑castus induces apoptosis in cancer cells by activating FoxO3a. (spandidos-publications.com)
  • Conversely, FOXO3a overexpression suppresses cancer cell growth, induces apoptosis, and reduces tumor size by regulating downstream effectors ( 10 ). (spandidos-publications.com)
  • This work adds to the elucidation of the molecular mechanisms behind cell cycle arrest preceding tumor cell apoptosis induced by ASncmtRNA knockdown. (uandes.cl)
  • With the increased understanding of molecular mechanisms and basic pathways in the pathogenesis of squamous cell cancer of the head and neck , these pathways may be modified, and rational approaches in cancer therapy at the molecular level may be created. (medscape.com)
  • Despite numerous inquiries into protective roles of lycopene in prostate cancer prevention or therapy, little is known about mechanisms by which lycopene or its metabolites inhibit prostate cancer. (nih.gov)
  • Herein, DNA microarray analysis was conducted to investigate the common mechanisms responsible for the antitumor effects of butyric acid, isobutyric acid and acetic acid on human colorectal carcinoma cells and identified candidate signal transduction pathways using the Ingenuity Pathway Analysis (IPA) software. (iiarjournals.org)
  • However, the mechanisms by which blockade of G9A leads to a tumor suppressive effect remain poorly understood. (nih.gov)
  • Cancer stem cells are a selective clonal subset of tumour cells that have avoided various cell regulatory mechanisms, including terminal differentiation, and yet have retained the self-renewal properties and proliferative potential of adult stem cells. (who.int)
  • We review the possible roles for calorie restriction (CR) and very low carbohydrate ketogenic diets (KDs) in modulating the five R's of radiotherapy to improve the therapeutic window between tumor control and normal tissue complication probability. (springer.com)
  • indicated that ATMs colocalized with T cells in lymphoid clusters within adipose tissue and may act as APCs, which express high levels of MHCII and also costimulatory molecules and process and present antigens to induce CD4+ T-cell proliferation and activation in adipose tissue of obese mice (29, 68, 105). (exposed-skin-care.net)
  • However, its role in aging-related adipose tissue CD4+ T cell activation remains to be investigated. (exposed-skin-care.net)
  • CD8+ T Cell Activation Compared to CD4+ T cells, CD8+ T cells show a greater increase in adipose tissue in obesity and in aging (31, 43, 106). (exposed-skin-care.net)
  • Similar to CD4+ T cells, CD8+ T cells exhibit effector memory or effector phenotypes expressing elevated levels of IFN- in obese adipose tissue (31, 44). (exposed-skin-care.net)
  • The mechanism for CD8+ T cell activation in adipose tissue is not fully understood. (exposed-skin-care.net)
  • showed that adipose tissue from obese mice induced proliferation of splenic CD8+ T cells, indicating a CD8+ T cell-activating environment in obese adipose tissue (31). (exposed-skin-care.net)
  • Indeed, CD8+ T cells from mouse adipose tissue respond to cytokines and become activated and proliferate under stimulation of IL-12 and IL-18, which are mainly produced by APCs and are elevated in obese adipose tissue (44). (exposed-skin-care.net)
  • The same treatment, however, does not affect normal tissue, suggesting this approach for the development of an efficient and safe therapeutic strategy for several cancer types. (intechopen.com)
  • The existence of stem cells in hematological tissue prompted research in other tissue cancer types. (atlasantibodies.com)
  • However, different markers can be used depending on the tissue where the tumor is generated. (atlasantibodies.com)
  • Cancers can occur in most parts of the body and can be classified by the area of the body in which they arise or by the type of tissue or cell that formed them. (healthandenvironment.org)
  • The molecules are found on the cell surface, where they facilitate adhesion to neighboring cells or the extracellular matrix, creating stable cell structures and supporting tissue organization. (pharmiweb.com)
  • An ovarian cyst is an abnormal growth of tissue that forms on the surface of the ovary and includes fluid. (cancer.net)
  • 2. Mode of carcinogenic action cell and tissue changes over time. (cdc.gov)
  • This family, which includes epidermal growth factor receptor (EGFR), plays a pivotal role in normal cell growth, lineage determination, repair, and functional differentiation. (medscape.com)
  • Abstract Fos-related antigen 1 (Fra-1) is a nuclear transcription factor that regulates cell growth, differentiation, and apoptosis. (techscience.com)
  • Let-7 Let-7 has an essential role in cell cycle and the differentiation of cell cycle terminals. (ukessays.com)
  • therefore, definitive differentiation of Hürthle cell carcinoma from Hürthle-cell adenoma is based on vascular invasion and/or capsular invasion, as well as on permanent histologic sections or extrathyroidal tumor spread and lymph node and systemic metastases. (medscape.com)
  • A tumor suppressor gene, also known as anti-onco gene, is an essential component of the body's defense against cancer. (pharmiweb.com)
  • Experiments in simple organisms, human cells, and mice indicated that these effects of fasting were caused by changes inside and outside cells that increased the death of tumor but not normal cells, a process termed differential stress sensitization. (kingdomfasting.com)
  • The few ASncmtRNAs copies in tumor cells seem essential to tumor cell viability: knockdown of these transcripts with antisense oligonucleotides (ASO) causes massive apoptotic death of tumor cells, preceded by cell cycle arrest. (intechopen.com)
  • We demonstrated that NBPF1 exerts different tumor suppressive effects, depending on the cell line analyzed, and provide new clues into the molecular mechanism of the enigmatic NBPF proteins. (biomedcentral.com)
  • The goal of specific molecular targets in cancer therapy is to create a "magic bullet" that selectively kills cancer cells. (medscape.com)
  • As our understanding of the molecular biology of HNSCC continues to develop, we can target the specific components of cancer cells that are not found in normal cells. (medscape.com)
  • Targeted molecular therapy can also act as a complement to other existing cancer therapies. (medscape.com)
  • Here we propose an integrative method based on the bootstrapping Kolmogorov-Smirnov test and a large set of microarray data produced with various types of cancer to discover common molecular changes in cells from normal state to cancerous state. (hindawi.com)
  • Furthermore, these methods fail to grasp the common molecular changes in cells transitioning from a normal state to the cancerous state. (hindawi.com)
  • Antonio Giordano, MD, PhD, is an oncologist and geneticist, as well as founder and president of the Sbarro Health Research Organization and director of the Sbarro Institute for Cancer Research and Molecular Medicine at Temple University in Philadelphia, Pennsylvania. (newswise.com)
  • He works on molecular therapeutics and also studies the connections between obesity and cancer. (newswise.com)
  • The inhibition of cell proliferation was quantified using the WST-8 assay kit (Dojindo Molecular Technologies, Inc., Kumamoto, Japan) by spectrophotometrically measuring the absorbance (450 nm) of the water-soluble formazan formed via reduction by intracellular dehydrogenases. (iiarjournals.org)
  • A key feature will be molecular strategies for cancer therapy. (york.ac.uk)
  • These results may provide a molecular explanation for the role of caveolin-1 as tumour suppressor and provide insight into the mechanism of anchorage-independent growth, one of the hallmarks of cancer. (europa.eu)
  • Ovarian cancer incidence is generally lower in Asia and the Middle East than in the United States and Europe, but new cases are relatively young [ 2 ]. (hindawi.com)
  • In China, the age-standardized incidence of ovarian cancer ranged from 4.75 to 6.05 per 100,000 population from 1999 to 2010, while the overall age-standardized incidence for these years was 5.35 per 100,000 population [ 3 ]. (hindawi.com)
  • The incidence of cervical cancer is increasing worldwide. (iiarjournals.org)
  • Although total cancer incidence (number of new cases diagnosed in a year) is divided roughly equally between men and women, the types of cancer are not. (healthandenvironment.org)
  • In the US, the incidence of cancer varies by state. (healthandenvironment.org)
  • While the incidence and mortality of all cancers combined is decreasing, specific cancers, including cancers among children, are on the rise. (healthandenvironment.org)
  • Furthermore, MWCNT inhalation increased the incidence of serosal tumors consistent with the diagnosis of sarcomatous mesothelioma from 2% in the MCA-exposed mice to 9% in the MCA/MWCNT, a 4.5 fold increase. (cdc.gov)
  • Breast cancer is a public health problem, its incidence increases worldwide. (bvsalud.org)
  • In addition, proteome analysis of NBPF1-overexpressing DLD1 cells identified 32 differentially expressed proteins, of which several are implicated in carcinogenesis. (biomedcentral.com)
  • Our results suggest that ASncmtRNA targeting blocks tumor cell proliferation through reduction of essential cell cycle proteins, mediated by mitochondrial and nuclear miRNAs. (uandes.cl)
  • While normal cells deprived of nutrients enter a dormant state similar to hibernation, the researchers saw that the cancer cells tried to make new proteins and took other steps to keep growing and dividing. (sciencedaily.com)
  • His early research includes seminal work done in 1989, demonstrating the importance of cell cycle proteins in the functioning of DNA tumor viruses. (newswise.com)
  • Many tumor suppressor proteins play a role in DNA repair, helping to correct genetic mutations and maintain the stability of the genome. (pharmiweb.com)
  • Cell adhesion molecules are a diverse group of proteins that play a crucial role in mediating cell-to-cell interactions and cell-to-extracellular matrix interactions. (pharmiweb.com)
  • Cells depend on their DNA for coding information to make various classes of proteins that include enzymes, certain hormones, transport proteins, and structural proteins that support life. (cdc.gov)
  • However, whether casticin inhibits in vitro carcinogenesis and cancer stem cell (CSC) characteristics, and whether casticin activates FoxO3a in small cell lung cancer (SCLC) cells remain unclear. (spandidos-publications.com)
  • Emerging evidence suggests that cancer stem cells (CSCs), a subpopulation of tumor cells, have the properties of self-renewal, heterogeneous progeny, drug-resistance, and carcinogenesis in vitro and in vivo ( 4 , 5 ). (spandidos-publications.com)
  • However, whether casticin inhibits in vitro carcinogenesis and CSC characteristics in the SCLC H446 cell line, and activates FoxO3a remains unclear. (spandidos-publications.com)
  • In vitro genotoxicity investigations have shown that high aspect ratio carbon nanotube s induce cell cycle disruption and errors in chromosome number. (cdc.gov)
  • Small cell lung cancer (SCLC), a poorly differentiated and highly aggressive tumor, constitutes approximately 15% of all lung cancers ( 1 ). (spandidos-publications.com)
  • Although Hürthle cell carcinoma was previously considered a variant of follicular cell neoplasms, which are generally less aggressive, the 2017 World Health Organization (WHO) classification of endocrine tumors reclassified it as a distinct entity. (medscape.com)
  • Inflammatory Breast Cancer (IBC) is a rare and very aggressive type of cancer that tends to develop at a younger age, compared with other subtypes of breast cancer. (bvsalud.org)
  • Inflammatory Breast Cancer (IBC) is a rare, although highly aggressive and lethal 3 type of cancer. (bvsalud.org)
  • Longo speculated that cells inside a large tumor may be protected in some way or that the variety of mutations in a large mass may make it more adaptable. (sciencedaily.com)
  • When the cell cycle proceeds without control, cells can divide without order and accumulate genetic errors that can lead to a cancerous tumor . (medlineplus.gov)
  • A cancerous tumor is malignant, meaning it can grow, invade, and spread to other parts of the body. (cancer.net)
  • Taken together, one important mechanism for obese adipose CD4+ T cell activation may be mediated through MHCII expressed on ATMs and adipocytes. (exposed-skin-care.net)
  • In their study publishing December 20 in Nature Cancer , first author Lin Wang , PhD and senior author Aaron Diaz , PhD, found that phenotype switching, as opposed to genetic evolution, may be the escape mechanism that explains the failure of precision therapies to date. (ucsf.edu)
  • Through 13C-labeled isotope labeling experiments we elucidate that exosomes supply amino acids to nutrient-deprived cancer cells in a mechanism similar to macropinocytosis, albeit without the previously described dependence on oncogenic-Kras signaling. (elifesciences.org)
  • These findings reveal a novel mechanism for regulating AMPK/FoxO3a signaling in response to casticin, suggesting a new strategy for SCLC therapy by targeting cancer stem‑like cells. (spandidos-publications.com)
  • The main goal of this research proposal is to study the relevance of this novel mechanism to cancer. (europa.eu)
  • The CT genotype of E2F1 gene rs3213172 polymorphism is associated with an increased risk of ovarian cancer, and E2F1 gene rs3213172 polymorphism may be a novel marker for the risk prediction of ovarian cancer. (hindawi.com)
  • Epidemiologic evidence indicates that lower circulating vitamin D levels are associated with a higher risk of ovarian cancer and that vitamin D supplementation is associated with decreased cancer mortality. (mdpi.com)
  • Based on this updated knowledge, when discussing contraception to avoid future pregnancy, some doctors recommend removal of the fallopian tubes, rather than tying or banding the tubes, in order to lower the risk of ovarian/fallopian tube cancers. (cancer.net)
  • Notably, restoring bco2 expression in prostate cancer cells inhibited cell proliferation and colony formation, irrespective of lycopene exposure. (nih.gov)
  • Further exploration showed that TSPAN12 overexpression accelerated proliferation and colony formation of OVCAR3 and SKOV3 OC cells. (molcells.org)
  • Knockdown of TSPAN12 expression in A2780 and SKOV3 cells decreased both proliferation and colony formation. (molcells.org)
  • The present study is aimed at exploring whether rs3213172, rs3213173, and rs3213176 polymorphisms of the E2F1 gene confer risk for ovarian cancer. (hindawi.com)
  • E2F1 gene rs3213173 and rs3213176 polymorphisms confer no risk to ovarian cancer risk. (hindawi.com)
  • The present study is to explore whether E2F1 gene polymorphisms confer risk for ovarian cancer. (hindawi.com)
  • Various techniques have been developed for targeting cancer cells: gene therapy, monoclonal antibodies (MAbs), antibody toxin conjugates, small-molecule inhibitors, antisense molecules, and tumor vaccines. (medscape.com)
  • The goal of gene therapy is to introduce new genetic material into cancer cells that selectively kills them without causing toxicity to the surrounding cells. (medscape.com)
  • We evaluate our method using three key pathways related to cancer and demonstrate that it is capable of finding meaningful alterations in gene relations. (hindawi.com)
  • 19 ] proposed a similar method to identify differential gene-gene coexpression patterns in cells from normal state to cancerous state. (hindawi.com)
  • 22 ] introduced a model to find differential gene coexpression patterns related to cancer by combining independent datasets for different cancers. (hindawi.com)
  • Table 1 provides a summary of cancers and gene mutations. (frontiersin.org)
  • From each tumor biopsy, they performed single-nucleus RNA-seq which measures transcriptome-wide gene expression in individual cells, for thousands of cells at a time. (ucsf.edu)
  • He has published over 600 papers on gene therapy, cell cycle, genetics of cancer, and epidemiology. (newswise.com)
  • This study evaluates the effect of A. montana leaves hexane extract on several signaling cascades and gene expression in metastatic breast cancer cells upon insulin-like growth factor-1 (IGF-1) stimulation. (techscience.com)
  • Integrins are key regulators of gene expression, cell proliferation and migration. (europa.eu)
  • By contrast, a limited exposure to a severely restricted diet (short-term starvation or fasting) can protect yeast, mammalian cells, mice, and possibly patients from the toxic effects of oxidative and chemotherapeutic agents without causing chronic weight loss (10-14). (kingdomfasting.com)
  • In mice, Yang's team found that the contents released from burst nuclei triggered growth-promoting signaling in nearby mammary tumor cells and accelerated the growth of metastatic tumors. (cancer.gov)
  • Another statement showed the preadipocyte- and endothelial cell-derived stromal-derived element-1 (CXCL12), mediated early infiltration of CD4+ T lymphocytes in obesity, which preceded the increase of macrophages in adipose cells of mice on HFD (101). (exposed-skin-care.net)
  • Indeed, the principal adipocytes isolated from obese mice could induce antigen-specific Compact disc4+ T cell activation (58). (exposed-skin-care.net)
  • Materials and Methods: Twenty-four nude mice were subcutaneously injected with HeLa cells. (iiarjournals.org)
  • The experimental design for the demethoxycurcumin (DMC) treatments in human cervical HeLa cell-bearing mice. (iiarjournals.org)
  • In the KpB mice fed a high fat diet (obese) and treated with celecoxib, tumor weight decreased by 66% when compared with control animals. (houstonmethodist.org)
  • Among KpB mice fed a low fat diet (non-obese), tumor weight decreased by 46% after treatment with celecoxib. (houstonmethodist.org)
  • In the ovarian tumors from obese and non-obese KpB mice, treatment with celecoxib as compared to control resulted in decreased proliferation, increased apoptosis and reduced COX-2 and MMP9 protein expression, as assessed by immunohistochemistry. (houstonmethodist.org)
  • At the end of seven weeks, the fasted mice had virtually no detectable cancerous cells compared to an average of nearly 68 per cent of cells found to be cancerous in the test areas of the non-fasted mice, showed the findings published online in the journal Nature Medicine . (drsircus.com)
  • Twenty three percent of the filtered air controls, 27% of the MWCNT-exposed, and 52% of the methylcholanthrene (MCA) followed by air-exposed mice, had a mean of 1.3, 1.3 and 1.4 lung tumors per mouse, respectively. (cdc.gov)
  • By contrast, 91% of the mice exposed to MCA followed by inhaled MWCNTs (MCA/MWCNT) had an average of 3.24 tumors per mouse. (cdc.gov)
  • however, the treatment of patients with cervical cancer depends on the cancer stage and tumor location according to diagnosis and characteristics of the patients ( 7 , 8 ). (iiarjournals.org)
  • Diagnosis Multiple endocrine neoplasia, type 1 (MEN 1) is an autosomal dominant syndrome characterized by hyperplasia or adenomas of the parathyroid glands, pancreatic islet cell tumors (also known as. (msdmanuals.com)
  • tion of these treatments and the oral antimicrobial drugs, Tularemia with peritonitis developed in a 50-year-old the abdominal lymphadenopathy showed improvement on man soon after diagnosis of stomach cancer with metasta- computed tomography. (cdc.gov)
  • Deaths from sporadic cancers (i.e. cancers for which no recognized exposure accounts for tumour development) may be prevented by screening or earlier diagnosis. (who.int)
  • This data will allow for analysis of the selected steroid hormones and related binding protein that can be used to assist in disease diagnosis, treatment, and prevention of diseases, such as Polycystic Ovary Syndrome (PCOS), androgen deficiency, certain cancers, and hormone imbalances. (cdc.gov)
  • This study is a systematic review of scientific articles on IBC with reference to the diagnosis, treatment, determinants and prognostics of this type of cancer. (bvsalud.org)
  • Despite significant recent improvements in the field of immunotherapy, cancer remains a heavy burden on patients and healthcare systems. (mdpi.com)
  • Besides, administration of concentrated extracts of Morinda citrifolia in tumor containing animals increased the immune response of the animals with a concomitant reduction in tumor burden 7 . (nature.com)
  • Air pollution, both outdoor and indoor, is the most widely investigated and most important contributor to the environmental cancer burden in human populations. (who.int)
  • 50% compared to untreated cells and the signalling pathways responsible for DLD-1 cell growth inhibition were identified and analyzed. (iiarjournals.org)
  • We here demonstrated that casticin decreased sphere‑ and colony‑formation capabilities, and downregulated uPAR and CD133 in second‑generation spheres, which were considered as lung cancer stem‑like cells (LCSLCs), from SCLC H446 cells, in a concentration‑dependent manner. (spandidos-publications.com)
  • They are commonly expressed in pluripotent embryonic stem cells, germ cells, certain committed progenitors, and cancer cells 18 . (atlasantibodies.com)
  • NB tumors are derived from the sympathetic nervous system and account for approximately 15% of cancer deaths in children [ 8 ]. (biomedcentral.com)
  • In an analysis of tumor samples from patients with breast or lung cancer, they found that outcomes tended to be worse when the genetic activity of patients' tumors indicated a high level of apoptosis-induced nuclear expulsion. (cancer.gov)
  • These mesenchymal transitions were apparent in the tumor samples after therapy, along with increased numbers of cycling mesenchymal cells. (ucsf.edu)
  • We found that normal human proliferating cells express a family of noncoding mitochondrial RNAs (ncmtRNAs), comprised of sense (SncmtRNA) and antisense (ASncmtRNA). (intechopen.com)
  • We find that CAF-derived exosomes (CDEs) inhibit mitochondrial oxidative phosphorylation, thereby increasing glycolysis and glutamine-dependent reductive carboxylation in cancer cells. (elifesciences.org)
  • This led to other relevant results, such as the reduction of some transcription factors, the inhibition of the activity of certain enzymes and the decrease of mitochondrial respiration and glycolysis of tumour cells. (agenciasinc.es)
  • When cancer cells die, they leave behind signals that spur the growth of the cells they've left behind, according to a new study led by Li Yang, Ph.D. , Senior Investigator in the Laboratory of Cancer Biology and Genetics . (cancer.gov)
  • Collaborating with Steven D. Cappell, Ph.D. , Stadtman Investigator in the Laboratory of Cancer Biology and Genetics, who applies state-of-the-art live-cell imaging approaches in his cell cycle research, they saw the nuclei of dying cells swell dramatically and then burst, spewing their DNA and other contents into their surroundings. (cancer.gov)
  • Biology Group (ICB) and the Infections evaluate the role of infections in human the pathway from discovery to public and Cancer Epidemiology Group (ICE). (who.int)
  • EPA published a proposal to replace its 1986 Guidelines for Carcinogen Risk Assessment to take advantage of these new scientific advances in cancer biology. (cdc.gov)
  • The FDA grants SN Bioscience's nano-therapy SNB-101 an orphan drug designation for small cell lung cancer (SCLC). (pharmaceutical-technology.com)
  • The US Food and Drug Administration (FDA) granted SN Bioscience an orphan drug designation for its small cell lung cancer (SCLC) drug SNB-101, a polymer nanoparticle drug. (pharmaceutical-technology.com)
  • Multiple SCLC characteristics, such as aggressiveness and high metastatic potential, suggest that this cancer could be enriched in CSCs ( 6 ). (spandidos-publications.com)
  • For lung cancers, CSC markers include CD44 and CD133 (PROM1), but also CD117 (KIT), CD90 (or THY1), CD166, EpCAM for non-small-cell lung carcinoma (NSCLC), and PODXL-1, PTCH, and CD87 for small-cell lung carcinoma (SCLC) 25 . (atlasantibodies.com)
  • Here we provide an overview of the most prominent CSC markers, focusing on solid cancers (lung, stomach, liver, breast, and colorectal cancers) and hematological cancers (acute and chronic myeloid leukemia). (atlasantibodies.com)
  • Emerging evidence suggests that sedentary behaviour is associated with an increased risk of cancers of the breast, colon, endometrium, and lung. (who.int)
  • Air pollution alone was responsible for an estimated 350 167 deaths from lung cancer worldwide in 2017. (who.int)
  • A subsequent in vivo multiwalled carbon nanotube (MWCNT) whole body inhalation exposure study further demonstrated that MWCNTs promoted the growth of DNA damaged (initiated) lung cells to form lung adenomas and adenocarcinomas. (cdc.gov)
  • Using intra-exosomal metabolomics, we provide compelling evidence that CDEs contain intact metabolites, including amino acids, lipids, and TCA-cycle intermediates that are avidly utilized by cancer cells for central carbon metabolism and promoting tumor growth under nutrient deprivation or nutrient stressed conditions. (elifesciences.org)
  • Scientists working in basic, translational, and clinical cancer metabolism research are invited to join the Academy in New York on April 17th to discuss the intersection between cell signaling and metabolism. (nyas.org)
  • Cancer Cell Metabolism: Unique Features Inform New Therapeutic Opportunities. (nyas.org)
  • Through manipulation of the circadian oscillation with bicarbonate, and shutting down the glucose metabolism of cancer cells with fasting, we can kick cancer cells down the block. (drsircus.com)
  • In prostate cancer cells, SRC-2 stimulated reductive carboxylation of α-ketoglutarate to generate citrate via retrograde TCA cycling, promoting lipogenesis and reprogramming of glutamine metabolism. (jci.org)
  • The Warburg phenotype provides tumors an enhanced resistance against cytotoxic insults. (springer.com)
  • However, if these therapies are not destroying CSCs, the tumor will soon grow back, often with high resistance to treatments 2 . (atlasantibodies.com)
  • However, cancer may develop resistance to chemotherapies and lead to treatment failure ( 9 , 10 ). (iiarjournals.org)
  • However, most pancreatic cancer patients carry wild-type BRCA1/2 with resistance to PARP inhibitors. (techscience.com)
  • Ideal targets should be both specific to cancer cells and commonly found in cancer cells. (medscape.com)
  • With access to thirty years' worth of GBM's, the scientists were able to present novel cell-intrinsic and cell-extrinsic targets as well as a single-cell multi-omics atlas of GBM under therapy. (ucsf.edu)
  • DNA microarray analysis has contributed to our knowledge of tumour biomarkers and their potential suitability as targets of anticancer therapy as revealed by bioinformatics analyses ( 11 - 13 ). (iiarjournals.org)
  • Therefore, miRNAs could consider as cancer targets. (ukessays.com)
  • however, these factors have potential as cancer therapy targets. (jci.org)
  • They will also help in identifying targets for cancer therapy. (europa.eu)
  • LC-MS/MS analysis was used to investigate the proteome of DLD1 colon cancer cells with induced NBPF1 expression. (biomedcentral.com)
  • In a preliminary study it has been shown that phenolic antioxidants such as methyl 4- O -galloylchlorogenate and 4- O -galloylchlorogenic acid derived from Sapota fruits can induce cytotoxicity in colon cancer cells 23 . (nature.com)
  • Our previous findings demonstrated that formononetin initiates growth-inhibitory and pro-apoptotic activities in human colon cancer cells. (spandidos-publications.com)
  • In the present study, we aimed to further examine the potential of formononetin in controlling angiogenesis and tumor cell invasiveness in human colon cancer cells and tumor xenografts. (spandidos-publications.com)
  • We also discovered that the invasiveness of metastatic colon cancer cells was alleviated following drug treatment. (spandidos-publications.com)
  • These findings suggest that formononetin inhibits angiogenesis and tumor cell invasion, and thus support its use in the treatment of advanced and metastatic colon cancers. (spandidos-publications.com)
  • In recent years, we focused on investigating the anti-carcinogenic properties of total Astragalus saponins (AST) in human colon cancer cells and tumor xenografts. (spandidos-publications.com)
  • These data indicate that AST may be an effective chemotherapeutic agent in colon cancer treatment, and may also be used as an adjuvant in combination with other orthodox chemotherapeutic drugs to reduce the side-effects of the latter compounds. (spandidos-publications.com)
  • Subsequent study using multiple human cancer cell lines, including those of the colon, stomach and liver, further indicated the universal growth-inhibitory and pro-apoptotic effects of AST. (spandidos-publications.com)
  • most breast, colon and prostate cancers are adenocarcinomas. (healthandenvironment.org)
  • For example, butyric acid has been found to up-regulate the expression of toll-like receptor 4 (TLR4) and the phosphorylation of MAPK and NK-κB in colon cancer cells in vitro ( 9 ). (iiarjournals.org)
  • Further, sodium butyrate has been shown to influence the adhesion and growth-regulating galectin network that controls the proliferation of human colon cancer cells in vitro ( 10 ). (iiarjournals.org)
  • Spanish and Italian researchers have proven that when honey from strawberry trees, a product typical of Mediterranean areas, is added to colon cancer cells grown in the laboratory, cell proliferation is stopped. (agenciasinc.es)
  • Now, scientists from the universities of Vigo and Granada (Spain) and from the Polytechnic University of Marche (Italy) have analysed for the first time the potential of this Mediterranean product to fight colon cancer. (agenciasinc.es)
  • The results, published in the Journal of Functional Foods, show that strawberry tree honey is capable of inhibiting the proliferation of tumour cells cultivated in laboratory plates - more specifically, those of a line of human colon adenocarcinoma (HCT-116) and another with metastatic characteristics (LoVo), widely used to investigate this type of tumour. (agenciasinc.es)
  • The cytotoxicity and anti-tumour effects of strawberry tree honey in relation to colon cancer lines increased with the amount and time of treatment. (agenciasinc.es)
  • None of these effects was observed when honey was applied to healthy cell lines," the authors point out, noting the anticarcinogenic potential of this natural product, but insisting on the need for new studies with colon cancer in vivo models to confirm its chemopreventive effects. (agenciasinc.es)
  • Strawberry tree honey is capable of inhibiting the proliferation of tumour cells on a line of human colon adenocarcinoma (HCT-116) and another with metastatic characteristics (LoVo). (agenciasinc.es)
  • In vitro, studies have shown that BZD dose-dependently inhibits colon cancer cell growth and invasion and promotes apoptosis. (bvsalud.org)
  • Although excess body fatness increases the risk of cancers at various organ sites, including the colon and rectum, the risk may be reduced by intentional weight loss. (who.int)
  • We don't know whether in humans it's effective," Longo said of fasting as a cancer therapy. (sciencedaily.com)
  • [ 1 ] Early stage head and neck squamous cell carcinoma (HNSCC) is treated relatively well with single-modality therapy (either surgery or radiation alone). (medscape.com)
  • We conclude that CR and KDs may act synergistically with radiation therapy for the treatment of cancer patients and provide some guidelines for implementing these dietary interventions into clinical practice. (springer.com)
  • Despite these advancements, several cancer types continue to elude modern treatment techniques with radiation therapy (RT). (springer.com)
  • They say it may be possible to block those signals to prevent cells that die during cancer therapy from provoking the growth of any cancer cells that remain. (cancer.gov)
  • They found that some cells shift to a mesenchymal, radiation-resistant phenotype (state) as a stress response following standard therapy. (ucsf.edu)
  • Our study concludes that, rather than a genetic evolution, there is a phenotypic plasticity or transition which allows these cells to evade therapy. (ucsf.edu)
  • The therapy causes DNA breaks, inhibiting DNA replication and shutting down the cell cycle to prevent tumour growth. (pharmaceutical-technology.com)
  • Poly(ADP-ribose) polymerase (PARP) inhibitors have been recently approved for BRCA1/2-mutant pancreatic cancer, opening a new era for targeted therapy for this disease. (techscience.com)
  • Fasting using bicarbonates in all ones water intake to wipe out cancer is a new therapy that is a game changer. (drsircus.com)
  • Furthermore, BZD has the potential to downregulate the PD-1 expression on T cell surfaces, indicating its ability to effectively restore T cell function by inhibiting immune checkpoints. (bvsalud.org)
  • The team suspects apoptotic cells may also help drive the growth of metastatic tumors in humans. (cancer.gov)
  • Traditionally the perspective on reactive oxygen species (ROS) has centered on the role they play as carcinogenic or cancer-causing radicals. (degruyter.com)
  • When the genetic information containing the "blueprint" for these substances is disrupted, cell homeostasis is disrupted, with a wide range of possible non-carcinogenic and carcinogenic toxicological effects. (cdc.gov)
  • 5) increasing the intrinsic radioresistance of normal cells through ketone bodies but decreasing that of tumor cells by targeting glycolysis. (springer.com)
  • ASncmtRNA knockdown with an antisense oligonucleotide induces massive apoptosis in tumor cell lines, without affecting healthy cells. (uandes.cl)
  • Here, we show that ASncmtRNA knockdown induces cell death preceded by proliferative blockage in three different human breast cancer cell lines. (uandes.cl)
  • The National Human Genome Research Institute's Talking Glossary provides information about the cell cycle . (medlineplus.gov)
  • Even fasting on its own effectively treated a majority of cancers tested in animals, including cancers from human cells. (sciencedaily.com)
  • The first cancer exomes were sequenced soon after the completion of the Human Genome Project in 2001. (frontiersin.org)
  • piloted the use of NGS to study the exomes of 140 samples of human acute myeloid leukemia (AML) cells in 2003, identifying 6 previously described and 7 undescribed mutations relevant for AMP pathogenesis. (frontiersin.org)
  • This study investigated expression and functional roles of BCO2 in human prostate cancer. (nih.gov)
  • Background/Aim: Demethoxycurcumin (DMC), a derivate of curcumin from natural plants, exerts antitumor effects on various human cancer cells in vitro and in vivo. (iiarjournals.org)
  • Nevertheless, no reports have disclosed whether DMC can affect the growth of human cervical cancer cells in vivo. (iiarjournals.org)
  • The anti‐proliferative activity of all newly synthesized compounds has been assessed against six human solid tumor cell lines. (researchgate.net)
  • All newly synthesized compounds were screened for anti‐proliferative activity against different human tumor cell lines. (researchgate.net)
  • Compound 5 showed high antiproliferative activity against several human tumor cell lines. (researchgate.net)
  • Cell culture and in vitro assessment of the inhibitory effects of butyric acid, isobutyric acid and acetic acid on the proliferation of a human colorectal carcinoma cell line. (iiarjournals.org)
  • The human colorectal carcinoma cell line (DLD-1 cells) was purchased from the Riken BRC Cell Bank, Japan. (iiarjournals.org)
  • For instance, overexpression of cyclins or the elimination of CDK inhibitors or pRB due to genetic mutation are common cause in human cancer. (ukessays.com)
  • With its absence, the human body will be functioning without its "brake" of cell proliferation. (pharmiweb.com)
  • Caveolin sporadic mutations occurring in human cancers will be tested for these effects. (europa.eu)
  • 27 samples consisting of MCF7 human breast cancer cells treated with 6 μM BIX-01294 in 0.1% dimethyl sulfoxide (DMSO) or 0.1% DMSO carrier controls and untreated controls in acute (4 hours) hypoxia, chronic (24 hours) hypoxia (1% O2) or normoxia (21% O2) control conditions in triplicate cultures. (nih.gov)
  • Cervical cancer may be eliminated as a public health problem by vaccination against human papillomavirus (HPV) infection, even in low-income countries where cervical cancer is the major cancer type. (who.int)
  • ICE research includes a wide portfolio of aim to evaluate the role of infectious study designs that are tailored to specific agents in human cancers through The overall strategy of ICE is to improve infectious agents across a spectrum of biological and epidemiological studies. (who.int)
  • The human body has nearly 1013 cells. (cdc.gov)
  • When the new guidelines assessing potential human cancer risk posed by envi- are final, EPA will make them available on the world ronmental agents, the concept of low-dose linearity wide Internet via its homepage ZHTTP:rrwww. (cdc.gov)