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ArsenicalsArsenicArsenic PoisoningCacodylic AcidArsenitesMelarsoprolIon PumpsAntimonyArsenite Transporting ATPasesArsenatesRoxarsoneTrypanocidal AgentsDimercaprolDiminazenePentamidineOxidesBowen's DiseaseAquaglyceroporinsEarly Detection of CancerSodium CompoundsProstatic NeoplasmsOvarian NeoplasmsBreast NeoplasmsWater Pollutants, ChemicalLung NeoplasmsDrinking WaterStomach NeoplasmsColonic NeoplasmsMethylationUrotheliumNucleoside Transport ProteinsMethyltransferasesNeoplasm MetastasisNeoplasm InvasivenessGlutathioneR FactorsTrypanosoma brucei bruceiPancreatic NeoplasmsNeoplasmsCrithidia fasciculataGene Expression Regulation, NeoplasticMice, NudeCancer VaccinesOrganometallic CompoundsSkin DiseasesNeoplasm ProteinsCell SurvivalDose-Response Relationship, DrugTrypanosomaSpectrophotometry, AtomicCarcinogensUterine Cervical NeoplasmsSurvival AnalysisGenetic Predisposition to DiseaseSurvival RatePrognosisAntineoplastic AgentsAntineoplastic Combined Chemotherapy ProtocolsDrug Resistance, NeoplasmCarcinomaSulfidesUrinary Bladder NeoplasmsCarcinoma, Non-Small-Cell LungCarcinoma, Squamous CellNational Cancer Institute (U.S.)Disease ProgressionRiskReverse Transcriptase Polymerase Chain ReactionMedicine, TraditionalFollow-Up StudiesCell Line, TumorColorectal NeoplasmsRetrospective StudiesEnvironmental ExposureTrypanosomiasis, AfricanReceptors, EstrogenGene Expression ProfilingRegistriesXenograft Model Antitumor AssaysSulfhydryl CompoundsUrinary BladderMolecular Sequence DataTumor Markers, BiologicalProspective StudiesDrug ResistanceMutationNeoplasm StagingRNA, MessengerMultienzyme ComplexesSurvivorsReceptor, erbB-2Risk AssessmentUnited StatesRectal NeoplasmsNeoplasm Recurrence, LocalOperonNeoplasm TransplantationDisease-Free SurvivalCombined Modality TherapyProstate-Specific Antigen
Arsenic TrioxideChronicKeratosisExposureCompoundsIntoxicationInsecticidesBladderArseniteInternational AgencyOrganicLung cancerIncidenceTissueInhibitionSymptomsEpidemiologyTherapeuticMetabolismMortalityProstateCompoundMalignantDiseasesTrialsRegistriesTreatmentRisksTypePatientsDeathsRiskPrimaryBoneOverviewWhiteBrain cancerHealthHigh
Arsenic Trioxide2
  • Trisenox (arsenic trioxide) is an arsenical. (centerwatch.com)
  • After being replaced by more selective and consequently less toxic antibiotics in the last century, arsenicals have recently made a resurgence as anticancer drugs (specifically arsenic trioxide and its derivatives). (strath.ac.uk)
Chronic5
  • Constipation is also a symptom of chronic arsenical intoxication. (armchairgeneral.com)
  • 12] Of note, chronic low-grade inflammatory processes are important causes of most diseases and conditions including cancer. (vitalitymagazine.com)
  • Chronic arsenical intoxication can still be found in environmental and industrial settings. (lookformedical.com)
  • Chronic exposure to arsenic can lead to serious health problems, including various cancers, cardiovascular diseases, skin disorders, and neurological effects. (sbistudy.com)
  • Disorders associated with acute or chronic exposure to compounds containing ARSENIC (ARSENICALS) which may be fatal. (harvard.edu)
Keratosis6
  • Here we report a rare case of arsenical keratosis presented with multiple polymorphic eruptions combined with chloracne. (symptoma.com)
  • Herein, we report a suspected case of palmoplantar arsenical keratosis in a patient from Newfoundland, Canada. (symptoma.com)
  • Keratotic nodular size will be measured of each patient to draw a conclusion about the effect of antimicrobials in patients with palmar arsenical keratosis . (symptoma.com)
  • Role of linoleic acid in arsenical palmar keratosis . (symptoma.com)
  • Dermatopathology of arsenical keratosis . (symptoma.com)
  • Arsenic-related Bowen's disease, palmar keratosis, and skin cancer. (lookformedical.com)
Exposure8
  • Organic arsenical exposure could result from a military chemical warfare (CW) attack or potentially from a terrorist incident. (medscape.com)
  • The onset of symptoms after arsenical exposure occurs in seconds as compared to 4-8 hours for mustard exposure. (medscape.com)
  • Arrighi HM, Hertz-Picciotto I. "Controlling the healthy worker survivor effect, an example of arsenic exposure and respiratory cancer. (osha.gov)
  • Synergism between occupational arsenic exposure and smoking in the induction of lung cancer. (osha.gov)
  • Residential pesticide exposure has also been associated with other childhood cancers (lymphoma, brain tumour, neuroblastoma, Wilm's tumour, and Ewing's sarcoma). (bmj.com)
  • Exposure to arsenic causes renal cancer. (springer.com)
  • The goal of this project is to characterize the role of MAsIII and DMAsIII in the diabetogenic effects of iAs exposure and to identify molecular mechanisms by which these arsenicals inhibit GSIS in pancreatic beta- cells. (usda.gov)
  • Every veteran who served in Vietnam between 1961 and 1975 is entitled to benefits if he or she subsequently suffers from one of a list of eight types of cancer and nine other diseases, regardless of proof of direct exposure to the chemical. (vietnamfulldisclosure.org)
Compounds3
  • Bibliography of Cancer produced by pure chemical compounds. (wikipedia.org)
  • Cytotoxic compounds that target the ER often exhibit selectivity for cancer cells over non-cancer cells. (annaryacat.de)
  • Arsenical compounds have been used therapeutically for over 2000 years finding particular relevance as antimicrobials. (strath.ac.uk)
Intoxication1
Insecticides2
  • Moreover, the International Agency for Research on Cancer (IARC) considers the "spraying and application of non-arsenical insecticides entailing exposures" to be, as a whole, probably carcinogenic to humans. (bmj.com)
  • The spread of mesothelioma to the wives and children of asbestos (1332214) workers through the carrying home of the fibers on their work clothes, the levels of arsenic in the urine and hair of children living near copper smelters, the increased rate of lung cancer among those living in areas where arsenical insecticides were used were noted. (cdc.gov)
Bladder2
  • As late as 1971 thousands of American workers were still exposed greatly to aromatic amines although the link between these substances and bladder cancer had been known for 80 years. (cdc.gov)
  • Chen CJ, Chen CW, Wu MM, Kuo TL (1992) Cancer potential in liver, lung, bladder and kidney due to ingested inorganic arsenic in drinking water. (springer.com)
Arsenite2
  • This metalloid occurs worldwide and many of its forms, especially arsenite [As(III)], cause various diseases including cancer. (biomedcentral.com)
  • Chen B, Arnold LL, Cohen SM, Thomas DJ, Le XC (2011) Mouse arsenic (+3 oxidation state) methyltransferase genotype affects metabolism and tissue dosimetry of arsenicals after arsenite administration in drinking water. (springer.com)
International Agency2
  • Source: International Agency for Research on Cancer (IARC). (healthandenvironment.org)
  • Arsenic, classified as a Group 1 human carcinogen by the International Agency for Research on Cancer, is the most prevalent water and environmental toxin [ 1 ], and ranks top of the US Priority List of Hazardous Substances. (biomedcentral.com)
Organic11
  • The 4 organic arsenicals are lewisite (L), methyldichloroarsine (MD), phenyldichloroarsine (PD), and ethyldichloroarsine (ED). These agents, together with the mustard agents and phosgene oxime, make up the vesicant class. (medscape.com)
  • [ 1 , 2 ] Although not as well known as the mustards, the organic arsenicals are a group of potent vesicants that medical planners should not overlook. (medscape.com)
  • Interest in organic arsenicals dates back to the mid-19th century. (medscape.com)
  • To fill this need, German chemists delivered the first weaponized organic arsenical, MD. (medscape.com)
  • Two additional organic arsenicals, PD and ED, soon augmented MD. While MD, PD, and ED were being deployed on the battlefields of Europe in 1917 and 1918, a team of American researchers, led by Captain Wilford Lee Lewis of the US Army Medical Corps, was working on the fourth and final organic arsenical. (medscape.com)
  • Although mustard vesicants have been used in numerous regional wars since 1918, organic arsenical weapons have had limited use. (medscape.com)
  • The relative ease of production coupled with their effectiveness against an unprotected population make organic arsenicals a continued threat in the 21st century. (medscape.com)
  • The exact mechanism of biological activity and toxicity of the organic arsenicals is unknown. (medscape.com)
  • The organic arsenicals tend to have high volatility at room temperature and thus pose a significant vapor threat to exposed personnel. (medscape.com)
  • Animal data and limited human trials demonstrated that organic arsenicals readily penetrate the skin. (medscape.com)
  • 2011). A recent report also indicates that the meat of broiler chickens fed a diet that included roxarsone, an organic arsenical feed additive that promotes growth and feed use, is a source of dietary arsenic, although it is not clear that the meat arsenic is the inorganic form (Gul Kazi et al. (nationalacademies.org)
Lung cancer6
  • For example, breast cancer that spreads to and forms a metastatic tumor in the lung is metastatic breast cancer, not lung cancer. (healthandenvironment.org)
  • 14 Cancers increasing in the US include lung cancer (especially in women), melanoma, non-Hodgkin lymphoma and myeloma. (healthandenvironment.org)
  • Coke oven workers in the steel industry exposed to coal combustion byproducts died of lung cancer at a rate of ten times that of other steel workers. (cdc.gov)
  • Some occupational groups exposed to arsenic (7440382) died of lung cancer at a rate of two to eight times the national level. (cdc.gov)
  • Similarly, uranium workers were still being exposed to radon daughters sufficient to cause lung cancer at three times the normal rate. (cdc.gov)
  • The data set of the lung cancer deaths from the mesothelioma tumors is used as an example to illustrate the effect on workers who are jointly exposed to two types of asbestos fibers, amphibole and chrysotile. (org.in)
Incidence4
  • Although total cancer incidence (number of new cases diagnosed in a year) is divided roughly equally between men and women, the types of cancer are not. (healthandenvironment.org)
  • In the US, the incidence of cancer varies by state. (healthandenvironment.org)
  • While the incidence and mortality of all cancers combined is decreasing, specific cancers, including cancers among children, are on the rise. (healthandenvironment.org)
  • Leukaemia is the most common cancer in childhood with an incidence rate of 43.1 per 1 000 000 per year in France 1 and, with the exception of ionising radiation and certain rare genetic syndromes, its aetiology remains largely unknown. (bmj.com)
Tissue2
  • What is certain is that a blistering reaction occurs on any tissue that an arsenical contacts, whether it is skin, eye, or pulmonary tissue. (medscape.com)
  • Cancers can occur in most parts of the body and can be classified by the area of the body in which they arise or by the type of tissue or cell that formed them. (healthandenvironment.org)
Inhibition1
  • Bergquist ER, Fischer RJ, Sugden KD, Martin BD (2009) Inhibition by methylated organo-arsenicals of the respiratory 2-oxo-acid dehydrogenases. (springer.com)
Symptoms1
  • Partition w into its four quadrants w0, w1, Леонов ВА (1975) Клинико-рентгенологическая характеристика рака желудка у лиц молодого возраста (Clin- ical and X-ray symptoms of gastric cancer in the 299 10 targeted specifically to adipocytes, are the β3-adreno- ceptor agonists such as the first generation compound BRL-37344 [(RR SS)-()-4-[2-(2-(3-chlorophenyl)- 2-hydroxyethyl)amino)propyl] phenoxyacetate]. (banglaforexacademy.com)
Epidemiology2
Therapeutic2
  • Arsenic: a beneficial therapeutic poison - a historical overview Arsenicals have been used since ancient Greek and Roman civilizations and in the Far East as part of traditional Chinese medicine. (ventolaphotography.com)
  • Klahn, S. Therapeutic innovations: Tyrosine kinase inhibitors in cancer. (eurekaselect.com)
Metabolism1
  • Methods: The association of arsenic metabolism phenotypes with participant characteristics and arsenical skin lesions was characterized among 4,794 participants in the Health Effects of Arsenic Longitudinal Study (Araihazar, Bangladesh). (johnshopkins.edu)
Mortality1
  • Inorganic arsenic is considered one of the prominent environmental causes of cancer mortality in the world. (all-creatures.org)
Prostate3
Compound1
  • This was accomplished with the use of several of the so-called rainbow chemicals-Agents Purple, Orange, White, and Blue (a powerful arsenical compound). (vietnamfulldisclosure.org)
Malignant1
  • Recent innovations in the genomic understanding of medulloblastomas have provided new ways to explore this highly invasive malignant brain cancer arising from the cerebellum. (geneticsmr.com)
Diseases2
  • Cancer is an assortment of more than 100 types of related diseases all characterized by uncontrolled cell growth. (healthandenvironment.org)
  • These people are at risk of developing cancer and nonmalignant diseases, including diabetes mellitus. (usda.gov)
Trials1
  • Search our clinical trials database for all cancer trials and studies recruiting in the UK. (shopwestcomb.com)
Registries2
  • Data are compiled from cancer registries that meet the data quality criteria for all invasive cancer sites combined for all years, 1999-2013 (covering approximately 92% of the U.S. population). (healthandenvironment.org)
  • http://dx.doi.org/ [Online 9 February 2005] was determined by comparing with the corresponding glioma cases in state cancer registries in all four states. (cdc.gov)
Treatment3
  • Fluorouracil cream and topical solution are also used to treat a type of skin cancer called superficial basal cell carcinoma if usual types cream treatment cannot be used. (shopwestcomb.com)
  • Paul Ehrlich used organoarsenic ("arsenicals") for the treatment of syphilis , demonstrating the relevance of metals, or at least metalloids, to medicine, that blossomed with Rosenberg's discovery of the anti-cancer activity of cisplatin (cis-PtCl 2 (NH 3 ) 2 ). (cloudfront.net)
  • Baudino, T.A. Targeted Cancer Therapy: The Next Generation of Cancer Treatment. (eurekaselect.com)
Risks2
  • Michigan, 86.5% for Minnesota, and 65.5% lead to higher risks of brain cancer in men rine pesticides was associated with reduced for Wisconsin. (cdc.gov)
  • For example, in March 2011, Unite, the largest manufacturing union in the UK released a brief to the media calling for an inquiry into cancer risks in the semiconductor manufacturing industry. (thethreewisemonkeys.com)
Type1
  • Metastatic cancer has the same name and the same type of cancer cells as the original cancer. (healthandenvironment.org)
Patients1
  • A multi-center pivotal trial was held, led by Memorial Sloan-Kettering Cancer Center, consisting of 40 patients ranging in age from 5 to 72. (centerwatch.com)
Deaths1
  • whose study looking at the deaths of men and women who had worked for IBM found "significantly greater" cancer deaths than the national average. (thethreewisemonkeys.com)
Risk2
  • and increased risk of skin cancers. (osha.gov)
  • So we risk poisoning people, or giving them cancer so as to gain 4.1% extra profit. (blogspot.com)
Primary1
Bone2
  • Bone cancer is osteosarcoma. (healthandenvironment.org)
  • But his vulnerability to a rare breakthrough infection was the result of two underlying conditions, Parkinson's disease and multiple myeloma, a cancer of the blood that destroys the bone marrow cells that strengthen the immune system. (vietnamfulldisclosure.org)
Overview1
  • This testimony before the Subcommittee on Oversight and Investigations provided an overview of the occupational causes of cancer. (cdc.gov)
White1
Brain cancer2
Health1
  • 16] In fact there's currently a coalition of families suffering serious health conditions suing chicken producers like Tyson after research showed cancer rates as much as 50 times above the national average in communities neighboring factory farmed poultry operations. (all-creatures.org)
High1