Cancer apoptosis inducing factor. Medical search. Frequent questions

Activating transcription factor-(ATF-) 3, a stress-inducible transcription factor, is rapidly upregulated under various stress conditions and plays an important role in inducing cancer cell apoptosis. (hindawi.com)
These results suggest that among various reactive species produced by PAM, hydrogen peroxide plays a key role in inducing cancer cell apoptosis. (hindawi.com)

First, we found that GS-002 significantly inhibited cell proliferation and induced cell apoptosis in dose-dependent manners. (hindawi.com)
ATF-3 induces DNA synthesis and expression of cyclin D1 in hepatocytes [ 21 ] and is involved in serum-induced cell proliferation as a target gene of c-myc [ 10 ]. (hindawi.com)
Krüppel-like factors can bind to specific DNA motifs and regulate various cellular functions, such as metabolism, cell proliferation, and differentiation. (medsci.org)
Although KLF6 overexpression in human cancer cells inhibits cell proliferation, induces apoptosis, and attenuates cell migration, the effects of KLF6 on oral cancer remains poorly elucidated. (medsci.org)
KLFs regulate a wide range of cellular functions, including cell proliferation, apoptosis, differentiation, and neoplastic transformation, by binding to GC-rich promoter regions [ 1 , 2 ]. (medsci.org)
In order to fulfill the increased biochemical demands that accompany increased proliferation, lipid metabolism is often dysregulated in cancer [12]. (researchsquare.com)
2003. Promotion versus suppression of rat colon carcinogenesis by chlorophyllin and chlorophyll: modulation of apoptosis, cell proliferation, and beta-catenin/Tcf signaling. . (oregonstate.edu)
The broad spectrum anti-tumor effects of calcitriol and analogs are mostly based on inhibition of cancer cell proliferation and invasiveness, induction of differentiation and apoptosis, and promotion of angiogenesis. (jcancer.org)
blood transfusion), spinal cord, lung cancer (oncology), respiratory cancer, radiology Background Multiple myeloma is a malignant proliferation of plasma cells mostly affecting the bone marrow and commonly presents with anaemia, hypercalcaemia, renal dysfunction, bone and skeletal involvement. (2011globalhealth.org)
At high concentrations, NSAIDs have anticarcinogenic properties operating through cyclooxygenase-2-dependent and -independent pathways to inhibit cellular proliferation, inhibit angiogenesis, and induce apoptosis. (medscape.com)
Combined with in-vitro proliferation assays using CRISPR-Cas9/RNAi and patient survival analysis, MEK inhibitors PD19830 and BRD-K12244279, pilocarpine, and tremorine were discovered as potential new drug options for treating breast cancer. (cdc.gov)

These results suggest that the induction of apoptosis by the propolis derivative, GS-002, is partially mediated through ER stress and ATF-3-dependent pathways, and GS-002 has the potential for development as an antitumor drug. (hindawi.com)
Ferroptosis-inducing factors can directly or indirectly affect glutathione peroxidase through different pathways, resulting in a decrease in antioxidant capacity and accumulation of lipid reactive oxygen species (ROS) in cells, ultimately leading to oxidative cell death. (nature.com)
My laboratory studies signal transduction pathways that regulate growth and programmed cell death in epithelial cancer cells, with a focus on breast and ovarian cancer. (cancer.gov)
There are many reports of apoptosis pathways induced by CAP, but for indirect treatment, there is still a lack of fundamental research on how CAP can cause apoptosis in cancer cells. (hindawi.com)
Like other TNF-family receptors and the IL-1 receptor, RANK mediates its signal transduction via TNF receptor-associated factor (TRAF) proteins, suggesting that the signaling pathways activated by RANK and other inflammatory cytokines involved in osteoclast differentiation and activation are interconnected. (umassmed.edu)
This study shows that as we begin to dissect the biochemistry of cancer, we can design therapies that interact within the critical pathways that are important for cancers to survive," said Keith L. Black, MD , director of the Institute and the Division of Neurosurgery at Cedars-Sinai. (cedars-sinai.org)
Cancer cell biology takes advantage of identifying diverse cellular signaling pathways that are disrupted in cancer. (eurekaselect.com)
On the other hand, non-genomic actions may indirectly affect gene transcription via the regulation of intracellular signaling pathways that target transcription factors ( 3 ). (jcancer.org)
Further investigations showed that pterostilbene reduced the level of lipopolysaccharide, modulated colon and brain TLR4/NF-κB signaling pathways, and decreased the release of inflammatory factors, which in turn inhibited intestinal inflammation and neuroinflammation. (qualitycounts.com)
One of the central anti-apoptotic pathways in cells is mediated by NF-kB nuclear factor kappa-B transcription factors. (dtic.mil)

In a second project we are investigating the induction of apoptosis by activation of death receptors for the ligand TRAIL in breast and ovarian cancer cells. (cancer.gov)
We have shown that most breast and ovarian cancer cell lines are resistant to the induction of apoptosis by TRAIL, the ligand for the death receptors DR4 and DR5. (cancer.gov)
Our current work utilizes biochemical and genetic approaches to identify mechanisms that regulate the induction of death by TRAIL ligand in breast and ovarian cancer cells. (cancer.gov)
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is known to cause apoptosis in several types of malignant tumor cells through its interaction with the death domain-containing receptor, death receptor 5 (DR5). (nih.gov)
In the present study, we showed that co-treatment with troglitazone (TGZ), a synthetic ligand of peroxisome proliferator-activated receptor γ (PPARγ), and TRAIL synergistically induced apoptosis through DR5 upregulation in human colon cancer DLD-1 cells. (nih.gov)
Studies in osteoclast biology have led to the identification of factors responsible for the differentiation and activation of osteoclasts, the most important of which is the receptor activator of NF-kappa B ligand/osteoclast differentiation factor (RANKL/ODF), a tumor necrosis factor (TNF)-like protein. (umassmed.edu)
Here, we describe a novel approach to functionalize human and murine leukocytes with tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) on their surface, along with E-selectin (ES), to capture and induce cancer cell apoptosis both in vitro in human blood and in vivo in mouse circulation. (aiche.org)
One such therapy, which Institute researchers have studied and are developing, centers on a protein called TRAIL (tumor necrosis factor related apoptosis inducing ligand). (cedars-sinai.org)
Designed tumor necrosis factor-related apoptosis-inducing ligand variants initiating apoptosis exclusively via the DR5 receptor. (crg.eu)
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a potential anticancer drug that selectively induces apoptosis in a variety of cancer cells by interacting with death receptors DR4 and DR5. (crg.eu)
The team found that a combination of Vitamin A acetate (RAc) and TRAIL, (tumor necrosis factor-related apoptosis-inducing ligand), kills precancerous polyps and inhibits tumor growth in mice that have deficiencies in a tumor-suppressor gene. (bioquicknews.com)

Breast cancer tumors that do not express hormone receptors or have amplification of Her2/Neu (so called triple-negative tumors) have a poor prognosis and no validated molecular targets. (cancer.gov)
1975 Munson shows anti cancer effects of cannabis in Lewis Lung Tumors. (greenmedinfo.com)
MDA-MB-435 cells engineered to be deficient in alpha6beta1 expression form primary tumors that are highly apoptotic and unable to metastasize, although they exhibit no increased apoptosis in vitro under standard culture conditions. (umassmed.edu)
Exposure to diethyl nitrosamine can induce more hepatic tumors in KLF6-/+ mouse than in wild-type animals [ 9 ]. (medsci.org)
The metabolic reprogramming is now understood to be linked to rapid growth of tumors, metastatic potential, resistance to chemotherapy, and cancer stemness [11]. (researchsquare.com)
2002. Sequencing of the rat beta-catenin gene (Ctnnb1) and mutational analysis of liver tumors induced by 2-amino-3-methylimidazo[4,5-f]quinoline. . (oregonstate.edu)
Subsequently, these two tumors have been grouped into a class of cancers entitled Ewing's Sarcoma Family of Tumor (ESFT), all of which demonstrate this translocation. (sarcomahelp.org)
SCR-6852, an oral and highly brain-penetrating estrogen receptor degrader (SERD), effectively shrinks tumors both in intracranial and subcutaneous ER + breast cancer models. (medscape.com)
[ 17-20 ] In vitro and in vivo research suggests that NSAIDs and selective cyclooxygenase-2 inhibitors hinder growth and survival of bladder cancer cells and nitrosamine-induced tumors. (medscape.com)
Six miRNAs had concordant expression in both tumors and breast cancer patient blood samples compared with the normal control samples. (cdc.gov)

To understand the functional interactions between the TrkA and p75 nerve growth factor (NGF) receptors, we stably transfected LAN5 neuroblastoma cells with an expression vector for ET-R, a chimeric receptor with the extracellular domain of the epidermal growth factor receptor (EGFR), and the TrkA transmembrane and intracellular domains. (umassmed.edu)
TRAIL can also bind to decoy receptors (DcR1, DcR2, and osteoprotegerin receptor) that cannot induce apoptosis. (crg.eu)
Correction: Expression of hormone receptors is associated with specific immunological profiles of the breast cancer microenvironment. (medscape.com)
e.g. inflammation, genotoxicity, and This chapter focuses on issues as- ellers, growth factors, growth factor epigenetic alterations) and can have sociated with the understanding and receptors, signal transducers, and both genetic and epigenetic origins. (who.int)

The CD56 bright population produces immunoregulatory cytokines, including interferon-γ (IFN-γ), tumor necrosis factor-beta (TNF-B), tumor necrosis factor-α (TNF-α), granulocyte macrophage-colony stimulating factor (GMCSF), IL-10, and IL-13 ( 4 ). (frontiersin.org)

Annonaceous acetogenin mimic AA005 reportedly inhibits mammalian mitochondrial NADH-ubiquinone reductase (Complex I) and induces gastric cancer cell death. (biomedcentral.com)
Gastric cancer is the fourth commonest ently reported that H. pylori eradication were subjected to routine history and malignant disorder and the second com- can lead to a regression of acute gastritis clinical examination, fol owed by an monest cause of cancer-related death and intestinal metaplasia, and that such upper gastrointestinal endoscopic ex- worldwide [1]. (who.int)

Apoptosis-inducing factor, mitochondria-associated 3 is a protein that in humans is encoded by the AIFM3 gene. (wikipedia.org)
However, denbinobin triggered the translocation of the apoptosis-inducing factor (AIF) from the mitochondria into the nucleus. (tmu.edu.tw)
ONC201 kills breast cancer cells in vitro by targeting mitochondria. (cancer.gov)

2) We investigate induction of apoptosis in breast cancer cells by TRAIL receptor agonists. (cancer.gov)
We have demonstrated that resistance to TRAIL-induced apoptosis can be overcome by co-incubation of the cells with chemotherapeutic agents, semi-synthetic retinoids (such as 4HPR), or molecularly targeted agents (such as anti-ErbB-2 antibodies). (cancer.gov)
We have recently demonstrated convincingly in melanoma and triple negative breast cancer cell lines that recombinant (r) hTRAIL together with several natural compounds (Quercetin, Silibinin, Ursolic Acid) are efficient in inducing apoptosis in previously described TRAIL-resistant cancer cell lines. (csuohio.edu)
To examine cancer cell capture and killing in vivo , mice were injected with ES/TRAIL retro-orbitally, followed by injection of FL-labeled COLO 205 cells via tail vein injection. (aiche.org)
Exposure of functionalized ES/TRAIL leukocytes into cancer cell-spiked blood successfully targeted and killed cancer cells under shear flow, compared to controls (Fig. 1B). (aiche.org)
Cancer cells lodged within the mouse lung were apoptotic after treatment with ES/TRAIL leukocytes, as determined by multiphoton microscopy. (aiche.org)
We have shown that leukocytes functionalized with ES/TRAIL can capture and induce cancer cell apoptosis in vitro in human blood and in vivo in mouse experiments. (aiche.org)
TRAIL has been shown to cause cell death in several types of cancers, with negligible damage to normal cells. (cedars-sinai.org)
Even wild-type TRAIL-insensitive ovarian cancer cell lines could be brought into apoptosis. (crg.eu)
In addition, our results demonstrate that there is no requirement for antibody-mediated cross-linking or membrane-bound TRAIL to induce apoptosis through DR5. (crg.eu)
RAc and TRAIL together killed premalignant polyps, causing programmed cell death known as apoptosis. (bioquicknews.com)

In the past decade, induction of apoptosis has become the major strategy to combat cancer. (hindawi.com)
Therefore, a search for innovative strategies other than induction of apoptosis is urgently needed. (hindawi.com)
HA14-1) that disable Bcl-2, resulting in induction of apoptosis in leukemia cell lines ( 8 ). (aacrjournals.org)
Now we have a drug that appears to lower thresholds for induction of apoptosis," said Yu, senior author of a paper describing the study in the Journal of Biological Chemistry, published online Nov. 30, 2005. (cedars-sinai.org)
Calcitriol elicits anti-tumor effects mainly through the induction of cancer cell apoptosis, cell cycle arrest, differentiation, angiogenesis and the inhibition of cell invasiveness by a number of mechanisms. (jcancer.org)
Growth inhibition, cell-cycle dysregulation, and induction of apoptosis by green tea constituent (-)-epigallocatechin-3-gallate in androgen-sensitive and androgen-insensitive human prostate carcinoma cells. (prostate.net)
Finally, the induction of cell death (apoptosis and pyroptosis) decreased the intracellular bacteria count in the infected bovine macrophages, suggesting that cell death helps to control the intracellular growth of the mycobacteria. (bvsalud.org)
Irish and Mechanistic data have been in- formation related to cancer induction Doxie, 2014) . (who.int)

The addition of a pan-caspase inhibitor (zVAD-fmk) did not suppress the denbinobin-induced apoptotic effect, and denbinobin-induced apoptosis was not accompanied by processing of procaspase-3, -6, -7, -9, and -8. (tmu.edu.tw)
AA005 induces a unique type of cell death in colorectal adenocarcinoma cells, characterized by lack of caspase-3 activation or apoptotic body formation, sensitivity to poly (ADP-ribose) polymerase inhibitor Olaparib (AZD2281) but not pan-caspase inhibitor Z-VAD.fmk, and dependence on apoptosis-inducing factor (AIF). (biomedcentral.com)
Our work may provide novel therapeutic clues for treating cancers via a non-canonical apoptotic pathway. (biomedcentral.com)
It does not have the morphological characteristics of typical necrosis, such as swelling of the cytoplasm and organelles and rupture of the cell membrane, nor does it have the characteristics of traditional cell apoptosis, such as cell shrinkage, chromatin condensation, formation of apoptotic bodies and disintegration of the cytoskeleton. (nature.com)
Mouse blood was removed via cardiac puncture, and viable and apoptotic cancer cells were analyzed using FC. (aiche.org)
Viable and apoptotic cancer cells lodged within the mouse lung, liver, and lymph nodes were quantified using multiphoton microscopy. (aiche.org)

In regards to cancer progression Snai2 and Snai1 are most commonly identified for their ability to induce epithelial-to-mesenchymal transition (EMT) resulting in a more migratory and invasive LY2603618 (IC-83) cancer phenotype. (bioinf.org)

We showed that denbinobin induces apoptosis in human colorectal cancer cells (HCT-116) in a concentration-dependent manner. (tmu.edu.tw)
2004. Activator protein 2alpha associates with adenomatous polyposis coli/beta-catenin and Inhibits beta-catenin/T-cell factor transcriptional activity in colorectal cancer cells. . (oregonstate.edu)

Previous studies reported that ATF-3 was induced by treating cells with antitumorigenic compounds [ 14 - 18 ] and a phosphoinositide 3-kinase inhibitor [ 19 ]. (hindawi.com)
Moreover, blocking activation of RIP-1 by necroptosis inhibitor necrotatin-1 inhibits AIF translocation and partially suppresses AA005-induced cell death in SW620 cells demonstrating that RIP-1 protein may be essential for cell death. (biomedcentral.com)
Both NGF and a caspase inhibitor reduced apoptosis and, thereby, enhanced differentiation. (umassmed.edu)
Translation elongation factor 1A2 (TEF1A2) is a tumor marker and an inhibitor of cadmium -induced apoptosis. (cdc.gov)
Based on this gene expression signature, the VEGFR inhibitor ZM-306416 was discovered as a new drug for treating breast cancer. (cdc.gov)

GS-002 also induced endoplasmic reticular (ER) stress as evidenced by increases in ER stress-responsive proteins including glucose-regulated protein 78 (GRP78), growth arrest- and DNA damage-inducible gene 153 (GADD153), phosphorylated eukaryotic initiation factor 2 α (eIF2 α ), phosphorylated protein endoplasmic-reticular-resident kinase (PERK), and ATF-3. (hindawi.com)
Krüppel-like factors (KLFs) are highly conserved zinc-finger proteins that regulate cellular transcription machinery [ 1 , 2 ]. (medsci.org)
The Cedars-Sinai researchers theorized that a diabetes drug called troglitazone would limit the effects of the overexpressed proteins, reinstating the caspase activity and the process of apoptosis. (cedars-sinai.org)
The effects of DNA methylation and the histone code are due, at least in part, to modification-specific recruitment of factors, such as heterochromatin-associated proteins (HP1) and methyl-binding domain proteins, which establish and maintain higher order of chromatin structure. (aacrjournals.org)
In addition, we also demonstrated that CREB and its associated proteins act as survival factors for human melanoma cells, thus, providing a mechanism, for the first time, on how overexpression of CREB in melanoma cells may contribute to the acquisition of the metastatic phenotype. (mdanderson.org)
Quercetin downregulates matrix metalloproteinases 2 and 9 proteins expression in prostate cancer cells (PC-3). (prostate.net)
Translation factors are essential for cells to synthesize proteins, and their aberrant expression may result in pathological conditions including cancer. (cdc.gov)
In addition, chronic diagnostic test for follow-up of patients cy and for biochemical determination inflammation associated with the infec- with H. pylori gastritis and were able of tissue COX-2 activity using COX tion leads to damage in proteins, the to predict the risk of development of Activity Assay Kit (Cayman Chemical production of reactive oxygen species stomach cancer. (who.int)
Serum amyloid A and alpha-1 acid glycoprotein are transport proteins, and fibrinogen is a coagulation factor. (msdmanuals.com)

In breast cancer, ATF-3 enhances cancer cell-initiating features [ 22 ] and is associated with activation of the canonical Wnt/ β -catenin pathway [ 23 ]. (hindawi.com)
their research had previous shown that NF-kappa B caused cancer cell migration in breast cancer too. (canceractive.com)
Dr Nakshratri of Indiana showed that a daily intake of Parthenolide could suppress metastases 'in vivo' in mice with breast cancer and could increase the response to Paclitaxel (taxol). (canceractive.com)
Both were shown to selectively decrease detyrosinated tubulin in cancer cells independent of their inhibition of NF-κB.The two compounds showed reduction in the frequency of microtentacles and inhibition of reattachment in breast cancer. (canceractive.com)
I am an attending physician in the Women's Malignancies clinic at NCI and in the Breast Cancer clinic at Walter Reed National Military Medical Center. (cancer.gov)
In our third project we are using functional genomic approaches and tumor genetics to identify new therapeutic targets in triple-negative breast cancer cells. (cancer.gov)
Although SLTM also suppressed the ability of oestrogen to activate a reporter gene in MCF-7 breast-cancer cells, inhibition of a constitutively active beta-galactosidase gene suggested that this was primarily the consequence of a generalized inhibitory effect on transcription. (bris.ac.uk)
This study is aimed at determining the effect of life behavioural patterns and diets in the incidence of breast cancer in Nigerians population. (academicjournals.org)
A prospective case-controlled study of 125 breast cancer. (academicjournals.org)
These results suggest a strong link between ovulatory menstrual cycles and the risk of developing breast cancer, with progesterone playing an important role. (medscape.com)
How do these two imaging modalities compare in terms of diagnostic accuracy for breast cancer detection? (medscape.com)
Learn more about CanAssist Breast -- a novel prognostic test for predicting the risk of breast cancer recurrence ten years after diagnosis. (medscape.com)
Certain modifiable factors may affect the risk for developing breast cancer. (medscape.com)
A better understanding of the potential risks of developing second primary malignancies among survivors of breast cancer could lead to better prevention and management strategies for these patients. (medscape.com)
Circulating 27-hydroxycholesterol, lipids, and steroid hormones in breast cancer risk: a nested case-control study of the Multiethnic Cohort Study. (medscape.com)
Publisher Correction: RAGE inhibition blunts insulin-induced oncogenic signals in breast cancer. (medscape.com)
A genome-wide gene-environment interaction study of breast cancer risk for women of European ancestry. (medscape.com)
Examination of fully automated mammographic density measures using LIBRA and breast cancer risk in a cohort of 21,000 non-Hispanic white women. (medscape.com)
miR-203 drives breast cancer cell differentiation. (medscape.com)
Association of air pollution with postmenopausal breast cancer risk in UK Biobank. (medscape.com)
MRI-based breast cancer radiogenomics using RNA profiling: association with subtypes in a single-center prospective study. (medscape.com)
Effectiveness of palbociclib with aromatase inhibitors for the treatment of advanced breast cancer in an exposure retrospective cohort study: implications for clinical practice. (medscape.com)
Correction to: National and subnational burden of female and male breast cancer and risk factors in Iran from 1990 to 2019: results from the Global Burden of Disease study 2019. (medscape.com)
Studying the association between longitudinal mammographic density measurements and breast cancer risk: a joint modelling approach. (medscape.com)
Noninvasive prediction of axillary lymph node breast cancer metastasis using morphometric analysis of nodal tumor microvessels in a contrast-free ultrasound approach. (medscape.com)
Correction: Changes in the tumor oxygenation but not in the tumor volume and tumor vascularization reflect early response of breast cancer to neoadjuvant chemotherapy. (medscape.com)
Correction: A prospective case-cohort analysis of plasma metabolites and breast cancer risk. (medscape.com)
Correction: Multimorbidity and overall survival among women with breast cancer: results from the South African Breast Cancer and HIV Outcomes Study. (medscape.com)
Clinical and biological heterogeneities in triple-negative breast cancer reveals a non-negligible role of HER2-low. (medscape.com)
Breast cancer treatment can be improved with biomarkers for early detection and individualized therapy. (cdc.gov)
From experimentally validated target genes of these 86 miRNAs, pan-sensitive and pan-resistant genes with concordant mRNA and protein expression associated with in-vitro drug response to 19 NCCN-recommended breast cancer drugs were selected. (cdc.gov)
Multi-omics biomarkers of response to the discovered drugs were identified using human breast cancer cell lines. (cdc.gov)
There is currently no gene expression assay that can assess if premalignant lesions will develop into invasive breast cancer. (cdc.gov)
The protein expression of PBX2 and RAD52 assessed with immunohistochemistry were prognostic of breast cancer survival outcomes. (cdc.gov)
This signature provided significant prognostic stratification in The Cancer Genome Atlas breast cancer patients (n = 1100), as well as basal-like and luminal A subtypes, and was associated with distinct immune infiltration and activities. (cdc.gov)
The mRNA and protein expression of the 26 genes was associated with sensitivity or resistance to 18 NCCN-recommended drugs for treating breast cancer. (cdc.gov)
Single nucleotide polymorphisms (SNPs) in miRNAs and risk of breast cancer have been evaluated in populations of European or Asian ancestry, but not among women of African ancestry. (cdc.gov)
SNPs in 6 miRNA processing genes and in 78 miRNAs which target genes known to be important in breast cancer among 906 African American (AA) and 653 European American (EA) cases and Author Manuscript controls enrolled in the Women's Circle of Health Study (WCHS). (cdc.gov)
We found a number of SNPs in miRNAs and processing genes in association with breast cancer overall or stratified by estrogen receptor (ER) status. (cdc.gov)
These data show, for the first time, that miRNA-related genetic variations may underlie the etiology of breast cancer in both populations of African and European ancestries. (cdc.gov)
In 2011, an estimated 230,480 new cases of breast cancer were diagnosed in women, and an estimated 39,520 women died from the disease [1]. (cdc.gov)
The incidence rates of breast cancer were higher in European American (EA) women while the death rates were higher in African American (AA) women [2]. (cdc.gov)
The disparities in breast cancer incidence and survival between AA and EA populations have been attributed to several factors, including disease management, access to proper care, and biological influences. (cdc.gov)
A recent study of the disparity in breast cancer mortality between AA and EA women concluded that differences in mortality are driven by higher hazard rates of breast cancer death in AA women, irrespective of ER expression [9]. (cdc.gov)

However, one pitfall observed throughout the years in in vitro and in in a multitude of human trials in vivo , is the resistance of cancer cell lines to hTRAIL-induced apoptosis. (csuohio.edu)

In addition, analysis of cell-cycle parameters, chromatin condensation and cytochrome c release showed that SLTM induced apoptosis in a range of cultured cell lines. (bris.ac.uk)
Rabbit polyclonal to Parp.Poly(ADP-ribose) polymerase-1 (PARP-1), also designated PARP, is a nuclear DNA-bindingzinc finger protein that influences DNA repair, DNA replication, modulation of chromatin structure,and apoptosis. (2011globalhealth.org)

As such, many studies on the mechanism by which CAP induces cancer cell death have been reported [ 26 - 33 ], but for the indirect treatment utilizing PAM, there is still a lack of research on physical changes in the stage before death occurs. (hindawi.com)
Another major part of the research work performed in my laboratory has to do with cancer and the understanding of the mechanism of apoptosis. (csuohio.edu)
Although most types of cells can be dismantled and cleared by apoptosis - a "programmed" and necessary cell death mechanism - gliomas and other cancer cells have genes that enable them to thwart apoptosis and continue to grow unchecked even when subjected to therapies that are designed to initiate or enhance apoptosis. (cedars-sinai.org)
Since TEF1A2 overexpression has previously been shown to be oncogenic, we have further investigated its role in apoptosis as a potential mechanism responsible for its oncogenic function. (cdc.gov)

Cytokines, cancer vaccines, adoptive cell transfers, and especially checkpoint inhibitors constitute valuable elements in the immunotherapeutic armamentarium. (frontiersin.org)
In addition, I am striving to establish a treatment for cancer that uses cytokines and natural non-toxic substances. (csuohio.edu)
Cancer immunotherapies can be divided into four major categories: - Cytokines/immunomodulation agents - Monoclonal antibodies - Cell‑based therapies - Oncolytic viruses Though monoclonal antibodies currently represent the largest class of commercialized cancer immunotherapies, cell‑based therapies are rapidly making headway. (technologynetworks.com)
NSAIDs inhibit cyclooxygenase-1 and cyclooxygenase-2, a rate-limiting enzyme induced by endogenous (growth factors or cytokines) and exogenous (tobacco carcinogens) stimuli, and are involved in prostaglandin synthesis and the inflammatory response. (medscape.com)

EGF activated the ET-R kinase and induced partial differentiation. (umassmed.edu)
NGF, which can bind to endogenous p75, did not induce differentiation but enhanced the EGF-induced response, leading to differentiation of almost all cells. (umassmed.edu)
Enhancement of EGF-induced differentiation required at least nanomolar concentrations of NGF, consistent with the low-affinity p75 binding site. (umassmed.edu)
These results demonstrate that TrkA kinase initiates differentiation, and p75 enhances differentiation by rescuing differentiating cells from apoptosis via the PI3K pathway. (umassmed.edu)
Transcription factors (TFs) are critical for B-cell differentiation, affecting gene expression both by repres- sion and transcriptional activation. (lu.se)

Our goal is to selectively trigger apoptosis in the cancer cells. (cancer.gov)

Overexpression of the chromosome 21 transcription factor Ets2 induces neuronal apoptosis. (nature.com)
p53 is a transcription factor that plays an important role in preventing cancer development. (molvis.org)
Using the Snail family as an example we LY2603618 (IC-83) discuss the concepts of functional redundancy and strategies employed to assay transcription factor families for "intra-member" compensation. (bioinf.org)

With caspase-3 activation blocked, apoptosis is halted and cancer cells grow uncontrolled. (cedars-sinai.org)

Our study is the first to provide demonstrate that KLF6 functions as a tumor suppressor gene and prevents the metastasis of oral cancer cells. (medsci.org)
Hematogenous metastasis contributes to a poor patient prognosis in many types of cancer, with over 90% of cancer-related death attributed to metastasis (1). (aiche.org)
For metastasis to occur, cancer cells detach from the primary tumor, invade through the basement membrane, and intravasate into the peripheral circulation as circulating tumor cells (CTCs) (2). (aiche.org)
The released NF-kB factors then translocate to the nucleus and activate kB-responsive genes involved in cell growth, apoptosis, and metastasis. (dtic.mil)
RHAMM regulates MMTV-PyMT-induced lung metastasis by connecting STING-dependent DNA damage sensing to interferon/STAT1 pro-apoptosis signaling. (medscape.com)

Taken together, our findings suggest that denbinobin induces apoptosis of human colorectal cancer HCT-116 cells via DNA damage and an AIF-mediated pathway. (tmu.edu.tw)
principle bioactive ingredient of the herb feverfew, has been shown on multiple occasions to attack cancer stem cells largely through the nuclear factor kappa-B pathway. (canceractive.com)
In one ( 4 ), parthenolide and a non-steroidal anti-inflammatory, sulindac, synergistically brought about growth suppression and inhibited the nuclear factor-kappa B pathway in pancreatic carcinoma cells. (canceractive.com)
Mechanistically, the CCL20/CCR6 signaling pathway upregulates HIF-1α by stimulating nuclear factor kappa B-driven transactivation of the HIF1A gene. (cancerindex.org)
2003. Caspase-8 and apoptosis-inducing factor mediate a cytochrome c-independent pathway of apoptosis in human colon cancer cells induced by the dietary phytochemical chlorophyllin. . (oregonstate.edu)
We have described and are exploiting a biochemical pathway to make brain cancers much more sensitive to common therapeutic agents that cause a natural process of cell death called apoptosis," said John S. Yu, MD , co-director of the Comprehensive Brain Tumor Program at the Institute, adding that the researchers are applying for Food and Drug Administration approval to translate their findings into patient clinical trials as soon as possible. (cedars-sinai.org)
One of the things we have learned is that there probably will not be one ultimate pathway in cancer that we can block and be curative. (cedars-sinai.org)
Pterostilbene could alleviate diabetic cognitive impairment by suppressing TLR4/NF-кB pathway through microbiota-gut-brain axis - Phytother Res 2023 Apr 10 - 'Diabetic cognitive impairment (DCI) is a serious neurodegenerative disorder caused by diabetes, with chronic inflammation being a crucial factor in its pathogenesis. (qualitycounts.com)
Quercetin regulates insulin like growth factor signaling and induces intrinsic and extrinsic pathway mediated apoptosis in androgen independent prostate cancer cells (PC-3). (prostate.net)
CFPE treatment and M. bovis infection also induce the maturation of IL-1ß (>3000 pg/mL), oligomerization of ASC (apoptosis-associated speck-like protein containing CARD), and activation of caspase-1, following the canonical activation pathway of the NLRP3 inflammasome. (bvsalud.org)

However, resistance to apoptosis is considered to be a characteristic of several types of cancers. (hindawi.com)
Usage of the murine IL-3 dependent Baf3 Pro-B cell line exhibited that overexpression of Snai2 was sufficient to confer resistance to apoptosis induced by growth factor withdrawal which was accompanied by exit from the cell cycle [21]. (bioinf.org)

Importance of epidermal growth factor receptor signaling in establishment of adenomas and maintenance of carcinomas during intestinal tumorigenesis. (nature.com)

EGF may induce a limited number of neuronal cells because it also enhanced apoptosis. (umassmed.edu)

however, forced KLF6 expression in lung cancer cell lines can trigger cells to undergo apoptosis and reduce colony formation ability [ 6 ]. (medsci.org)
Thus, by using natural non-harmful substances and rhTRAIL, under the conditions established, only cancer cells will undergo apoptosis while normal cells will not be affected. (csuohio.edu)
Oncogenic mutations or abnormal expression of signaling components disrupt the regulatory networks that govern cell function, thus enabling tumor cells to undergo dysregulated mitogenesis, to resist apoptosis, and to promote invasion to neighboring tissues. (eurekaselect.com)

The expression of HIF-1 downstream genes, cancer colony formation, and Matrigel invasion of glioblastoma cells were stimulated by conditioned medium from astrocytes pre-exposed to hypoxia. (cancerindex.org)
Inhibition of prostate cancer cell colony formation by the flavonoid quercetin correlates with modulation of specific regulatory genes. (prostate.net)
These novel changes induced by WNV may serve as of 173 cellular genes were identified by ArrayTools to be biomarkers and help explain the neuropathologic features differentially expressed in the WNV-infected A172 cells. (cdc.gov)

2003. Use of transgenic and mutant animal models in the study of heterocyclic amine-induced mutagenesis and carcinogenesis. . (oregonstate.edu)

Cancer cells avoid apoptosis by a variety of genetic and epigenetic mechanisms. (cancer.gov)

Recent advances in understanding the role that epigenetics plays in cancer pathogenesis and understanding the mechanisms through which these processes regulate gene expression have stimulated considerable interest in developing clinically viable antineoplastic agents that target enzymatic components of transcriptional regulatory complexes responsible for the establishment of pathologic epigenetic modifications that lead to deregulated gene expression in cancer. (aacrjournals.org)

The concentration of NO 2 - and H 2 O 2 in PAM cultured with cancer cells was measured, and intracellular reactive oxidative stress (ROS) changes were observed using flow cytometry. (hindawi.com)
Calcitriol induces a number of non-genomic responses including rapid intestinal absorption of calcium, release of calcium from intracellular stores, opening of voltage-gated calcium and chloride channels, and the activation of protein kinase C, protein kinase A, phosphatidylinositol-3 kinase (PI3K) and phospholipase C ( 4 ). (jcancer.org)

Recent studies have shown that in addition to necrosis and apoptosis, there are also other new programmed death modes, such as autophagy, necrosis and necrotic apoptosis, which have unique biological processes and pathophysiological characteristics. (nature.com)
Although M. bovis-induced inflammation actively participates in granuloma development, its role in necrotic cell death and in bovine macrophages has not been fully explored. (bvsalud.org)
Our results show that both stimuli induce necrotic cell death starting 4 h after incubation. (bvsalud.org)

The loss of KLF6 expression has been observed in several human cancers [ 4 - 7 ]. (medsci.org)

On the other hand, ATF-3 is rapidly induced in cells treated with growth stimulators such as serum and growth factors [ 20 ]. (hindawi.com)
Based on the hypothesis that alpha6beta1 is necessary for the survival of these cells in the tumor microenvironment, we report here that hypoxia protects these cells from apoptosis induced by serum deprivation and that hypoxia-mediated protection requires alpha6beta1 expression. (umassmed.edu)
We investigated the influence of alpha6beta1 on vascular endothelial growth factor (VEGF) expression because autocrine VEGF is necessary for the survival of serum-deprived cells in hypoxia. (umassmed.edu)
The effect of serum lipids on ovarian cancer is controversial. (researchsquare.com)
14] reported that women with a higher serum cholesterol level had an increased risk of ovarian cancer. (researchsquare.com)
15] found that oxidized low-density lipoprotein (ox-LDL) in serum was higher in ovarian cancer patients than in control subjects, but total cholesterol (TC) and high-density lipoprotein (HDL) showed no such association. (researchsquare.com)

NK cell infiltration into tumor tissue is associated with better disease prognosis in colorectal cancer, clear cell renal cell carcinoma, and lung carcinomas ( 9 - 11 ). (frontiersin.org)
When PAM was incubated with A549 lung cancer cells, there was little change in NO 2 - concentration, but the concentration of H 2 O 2 gradually decreased after 30 min. (hindawi.com)
Numerous epidemiological and preclinical studies support a role of vitamin D compounds in cancer prevention and treatment in colorectal, breast, prostate, ovarian, bladder, lung and skin cancers and leukemia ( 1 , 5 , 6 ). (jcancer.org)
Low levels of plasma 25(OH)D 3 are associated with higher cancer incidence and mortality in men in colorectal, breast, lung and prostate cancers ( 7 - 10 ). (jcancer.org)
We say "potential" since the scientists tested quercetin and EGCG on lung, kidney, and liver cells rather than prostate cancer cells. (prostate.net)
Bach P, Mirkin J, Oliver T, Azzoli C, Berry D, Brawley O. Benefits and harms of CT screening for lung cancer: a systematic review. (cdc.gov)
The nanotube bundles are similar to the potential of nanotubes to induce genetic damage size of microtubules that form the mitotic spindle in normal lung cells, cultured primary and immor- and may be incorporated into the mitotic spindle talized human airway epithelial cells were apparatus. (cdc.gov)

ABT-737 induces Bax conformational change but fails to activate Bak or trigger Bax translocation. (aacrjournals.org)
Apoptosis-inducing factor (AIF) translocation from themitochondria to the nucleus is PARP-1-dependent and is necessary for PARP-1-dependent celldeath. (2011globalhealth.org)

We conduct this study to evaluate the prognostic value of preoperative plasma lipid profile in patients with ovarian cancer. (researchsquare.com)
The medical records of 156 epithelial ovarian cancer patients who underwent surgical resection in our department were retrospectively reviewed and analyzed. (researchsquare.com)
Preoperative HDL-C and LDL-C levels are significant predictors of clinical outcome in patients with epithelial ovarian cancer. (researchsquare.com)
Epithelial ovarian cancer (EOC) is the most lethal gynecological malignancy [1]. (researchsquare.com)
Thus, it is important to search for effective and accessible prognostic factors to identify ovarian cancer. (researchsquare.com)
In the last decade, dysregulation of lipid metabolism has been increasingly recognized as a component of malignant transformation in many different cancers, including ovarian cancer [9,10]. (researchsquare.com)
Variations of plasma lipids and lipoproteins have been observed in ovarian cancer patients. (researchsquare.com)
Several studies have investigated whether the unbalanced lipid profile is associated with risk of developing ovarian cancer. (researchsquare.com)
In addition, it has been suggested that low levels of HDL could be reflective of an unfavorable hormonal profile which, in turn, would increase the risk of ovarian cancer [17]. (researchsquare.com)

Persistent infection with oncogenic HPV types can cause cervical cancer in women as well as other anogenital and oropharyngeal cancers in women and men. (cdc.gov)

Thus the inhibitory effects of SLTM on gene expression appear to result from generalized down-regulation of mRNA synthesis and initiation of apoptosis consequent upon overexpressing the protein. (bris.ac.uk)
The secretory phospholipase A2 gene is a candidate for the Mom1 locus, a major modifier of Apc Min -induced intestinal neoplasia. (nature.com)
Although genetics have played a dominant role in cancer research, epigenetics (heritable changes in gene function that do not involve alterations in DNA sequence) has become equally important in this field. (aacrjournals.org)
The identified transcription factors influence both the global and specific gene expression of the BCLs and have possible implications for diagnosis and treat- ment. (lu.se)
That gene, adenomatous polyposis coli (APC) and its downstream signaling molecules, are mutated or deficient in 80 percent of all human colon cancers, Dr. Wu said. (bioquicknews.com)
pendent of those associated with cretory ducts, columnar epithelia the KRAS gene is more frequent- other key mechanistic characteris- lining the gastrointestinal tract and ly mutated in human cancer, which tics of IARC Group 1 carcinogens. (who.int)
A set of 26-gene mRNA expression profiles were used to identify invasive ductal carcinomas from histologically normal tissue and benign lesions and to select those with a higher potential for future cancer development (ADHC) in the breast associated with atypical ductal hyperplasia (ADH). (cdc.gov)
This gene signature classified cancer development in ADH tissues with an overall accuracy of 100% (n = 8). (cdc.gov)

Blocking ROS formation significantly suppresses AA005-induced cell death in SW620 cells. (biomedcentral.com)

A combination of quercetin and EGCG synergistically inhibited cell growth and spread, interfered with the cell cycle, and induced cell death in prostate cancer cells. (prostate.net)

Exposure of CHO cells to 2.5 and 10 um cadmium chloride for 24-hours resulted in significant apoptosis in all cell lines at 24- and 48-hours following the exposure. (cdc.gov)
Nanotube exposure induces the nanotechnology industry is a multibillion dollar industry and is expected to reach a trillion dollars by 2015. (cdc.gov)

These variants do not induce apoptosis in DR4-responsive cell lines but show a large increase in biological activity in DR5-responsive cancer cell lines. (crg.eu)
For example, a State University of New York at Buffalo study showed that quercetin significantly inhibited the growth of prostate cancer cell lines and had a positive effect on cancer cell cycles. (prostate.net)
Presently, we have investigated the expression profile of TEF1A2 using a panel of human cancer cell lines and tumor tissues. (cdc.gov)
Up to a 2000-fold overexpression of TEF1A2 was detected in 90% (nine out of 10) of the cancer cell lines derived from various human tissues compared to their corresponding controls. (cdc.gov)

Hypoxia stimulates cancer cells to acquire a more malignant phenotype via activation of hypoxia-inducible factor 1 (HIF-1). (cancerindex.org)

We used mouse models of Down's syndrome and of cancer in a biological approach to investigate the relationship between trisomy and the incidence of intestinal tumours. (nature.com)
Genetic identification of Mom-1 , a major modifier locus affecting Min -induced intestinal neoplasia in the mouse. (nature.com)

MIF (macrophage migration inhibitory factor) is a pro-inflammatory cytokine that is released during microbial infection, ARDS, rheumatoid arthritis, atherosclerosis, type 2 diabetes, and cancer. (rndsystems.com)
KLF6 overexpression attenuated the migration and invasion of oral cancer SAS cells. (medsci.org)

The authors pointed out that combining quercetin and green tea enhanced the cancer fighting abilities of green tea (EGCG) and that "responses of different cancers to the combination may vary. (prostate.net)

These pro- has been implicated as contributing apoptosis, inflammation, and several liferating cel s replace dead cel s to the cancer phenotype, through pleiotropic responses. (who.int)

Thèse de Doctorat de l'Université Paris VI en Biochimie ( Ph.D. University of Paris in Biochemistry) 1989. (csuohio.edu)

Alternative techniques for detecting cancer of the cervix uteri alongside its early precancerous lesions still remain necessary for low income environments since morbidity and mortality due to cervical cancer continues to be on the rise. (academicjournals.org)
In Uganda, literature has shown that, cervical cancer incidence and death rates was 45.6 and 25 per 100,000 women respectively. (academicjournals.org)
Although most infections cause no symptoms and are self-limited, persistent HPV infection can cause cervical cancer in women as well as other anogenital cancers, oropharyngeal cancer, and genital warts in men and women. (cdc.gov)
Genital HPV types are categorized according to their epidemiologic association with cervical cancer. (cdc.gov)
Essentially all cervical cancers are attributable to high-risk HPV types ( 8 ), and approximately 70% of cervical cancer cases worldwide are caused by types 16 and 18 ( 9 ). (cdc.gov)
In addition to cervical cancer, HPV infection also is the cause of some other anogenital cancers such as cancer of the vulva, vagina, penis, and anus, as well as cancer of the oropharynx ( 6 ). (cdc.gov)
In addition, C. trachomatis has immunuofluorescence technique to agerangewas20-65years:28inthepa- been suggested to be a cofactor in the measurespecificantichlamydialIgG- tient group and 33 in the control group development of cervical cancer [ 2,3 ]. (who.int)

2009. E2F4 and ribonucleotide reductase mediate S-phase arrest in colon cancer cells treated with chlorophyllin. . (oregonstate.edu)

However, the cadmium -induced apoptosis was significantly lower in the transgenic CHO cells permanently overexpressing TEF1A2 compared with the vector-alone transfected control cells. (cdc.gov)

Traditionally, cell death has been divided into apoptosis and necrosis. (nature.com)

2004. The dietary phytochemical chlorophyllin alters E-cadherin and beta-catenin expression in human colon cancer cells. . (oregonstate.edu)

Anatomy20

Organisms7

Diseases38

Chemicals and Drugs92

Analytical, Diagnostic and Therapeutic Techniques and Equipment44

Psychiatry and Psychology1

Phenomena and Processes50

Disciplines and Occupations2

Anthropology, Education, Sociology and Social Phenomena1

Information Science5

Named Groups1

Health Care17

Geographicals1

Role in inducing cancer cell2

Proliferation11

Pathways10

Ligand11

Tumors10

Receptors4

Tumor necros1

Gastric cancer2

Mitochondria3

TRAIL11

Induction8

Apoptotic6

Ability to induce1

Colorectal cancer cells2

Inhibitor5

Proteins9

Breast cancer44

Vitro1

Chromatin2

Mechanism4

Cytokines4

Differentiation5

Selectively1

Transcription factor3

Caspase-3 activation1

Metastasis5

Pathway10

Resistance2

Receptor1

Neuronal1

Undergo3

Genes3

Carcinogenesis1

Genetic and epigenetic1

Antineoplastic Agents1

Intracellular2

Necrotic3

Several human cancers1

Serum6

Lung7

Translocation2

Ovarian9

Oncogenic1

Gene8

Suppresses1

Synergistically1

Exposure2

Cell lines4

Malignant1

Intestinal2

Migration2

Different cancers1

Inflammation1

Biochemistry1

Cervical cancer7

Mediate1

Significantly1

Necrosis1

Colon cancer cells1