• Here we show that methanolic extracts of Sapota fruit (MESF) induces cytotoxicity in a dose-dependent manner in cancer cell lines. (nature.com)
  • The short-chain fatty acid butyrate induces apoptosis in col. (lww.com)
  • Khz ( fusion of Ganoderma lucidum and Polyporus umbellatus mycelia ) induces apoptosis by increasing intracellular calcium levels and activating JNK and NADPH oxidase-dependent generation of reactive oxygen species. (springer.com)
  • Jin ML, Park SY, Kim YH, Park G and Lee SJ: Halofuginone induces the apoptosis of breast cancer cells and inhibits migration via downregulation of matrix metalloproteinase-9. (spandidos-publications.com)
  • In prostate cancer xenografts, a nondegradable IP3R3 mutant or an inhibitor that disrupted FBXL2 membrane localization sensitized tumors expressing low levels of PTEN to photodynamic therapy, which induces Ca 2+ -dependent cytotoxicity. (aacrjournals.org)
  • Raloxifene induces apoptosis in estrogen receptor-negative human cancer cells through the AhR. (oregonstate.edu)
  • We identified Y134 as a raloxifene analog that activates AhR-mediated transcriptional activity and induces apoptosis in MDA-MB-231 human triple negative breast cancer cells. (oregonstate.edu)
  • This study is the first to show that VALD-3 induces apoptosis and cell cycle arrest in human breast cancer cells by suppressing Wnt/β-catenin signaling, indicating that it could be a potential drug for the treatment of breast cancer. (researchsquare.com)
  • Exposure to UV induces extensive generation of reactive oxygen species (ROS), and results in photoaging and skin cancer development. (spandidos-publications.com)
  • Owing to differential expression in various tissues, some of these peptides serve as biomarkers and can also play immuno-modulatory roles within the immune landscape of cancer pathways such as Mucin, Melan-A-MART, PD-L1 etc. (eurogentec.com)
  • The first is to use an in vivo approach to analyse transgenic mice in which the autophagy regulator known as Beclin has been engineered to either disrupt or enhance its regulation by key components (i.e. proteins) of the apoptosis pathways. (edu.au)
  • Combined with the other studies in the Anticancer Drug Action Lab, our studies of apoptotic pathways are providing new insight into factors that govern cancer cell sensitivity to targeted anti-cancer agents and immunotherapy, while also elucidating the mechanisms of resistance to a variety of novel anti-cancer agents. (mayo.edu)
  • The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
  • Discover pathways on apoptosis induction, caspase activation and phagocytosis of apoptotic cells. (abcam.com)
  • The apoptosis was transduced by multiple signaling pathways mediated by FasL and TNFR2 and mainly activated the mitochondrial control of apoptosis via Bid and Bim, which was rescued by silencing Bid or/and Bim . (biomedcentral.com)
  • AZD2461 suppresses the growth of prostate tumor cells since AZD2461 monotherapy could prove to be efficacious, especially against cells not expressing PTEN besides activating the possible apoptosis-independent cell death pathways. (ac.ir)
  • Apoptosis can be initiated through one of two pathways. (wikipedia.org)
  • UV-B-induced DNA damage can trigger cell signaling pathways to activate defense systems, leading to DNA repair and/or apoptosis ( 6 ). (spandidos-publications.com)
  • These results suggest that the induction of apoptosis by the propolis derivative, GS-002, is partially mediated through ER stress and ATF-3-dependent pathways, and GS-002 has the potential for development as an antitumor drug. (hindawi.com)
  • To clarify the molecular basis of si-Vav3- and docetaxel-induced apoptosis, we analyzed alterations in phosphatidylinositol 3-kinase (PI3K)/Akt, extracellular signal-regulate kinase (ERK), c-jun N-terminal kinase (JNK), and AR pathways using kinase inhibitors in LNCaPH cells. (biomedcentral.com)
  • Interrupting Vav3 signaling enhances docetaxel-induced apoptosis in LNCaP cells under chronic hypoxia by inhibiting the PI3K/Akt, ERK, and AR signaling pathways. (biomedcentral.com)
  • Sesquiterpene lactones containing a 3-methylenedihydrofuran-2(3H)-one (or α-methylene-γ-lactone) moiety, for example damsin (1), are Michael acceptors that affect biological processes such as cell proliferation, death/apoptosis, and cell migration, by interfering with cell signalling pathways. (lu.se)
  • These findings indicate that sesamin inhibits cervical cancer cell proliferation, and its mechanism may be attributed to the induction of p53/PTEN-mediated apoptosis. (medsci.org)
  • Induction of apoptosis by ethanol extracts of Ganoderma lucidum in human gastric carcinoma cells. (springer.com)
  • Solanum nigrum (SN) is a herb with anticancer effects such as destruction of tumor cell membrane, induction of apoptosis by NF-kappaB, caspase activation, nitric oxide production and inhibition of angiogenesis [ 3 ]. (ijpsonline.com)
  • Therefore, remedies based on the induction of programmed cell death attracted greater attention for cancer treatment [ 8 ]. (ijpsonline.com)
  • Induction of apoptosis leads to characteristic cellular changes leading to death. (ijpsonline.com)
  • The enhanced anti-cancer effect of the combined use of dipyridamole with aspirin was found to rely on the induction of an overwhelmed endoplasmic reticulum (ER) stress and subsequent pro-apoptotic unfolded protein response (UPR), which was different from the anti-platelet effect. (lu.se)
  • We performed structure-activity studies with seven raloxifene analogs to better understand the structural requirements of raloxifene for induction of AhR-mediated transcriptional activity and apoptosis. (oregonstate.edu)
  • The GL-induced growth inhibition correlated with apoptosis induction as evidenced by an increase in cytoplasmic histone-associated DNA fragmentation and sub-G 0 /G 1 -DNA fraction, and cleavage of poly(ADP-ribose) polymerase. (aspetjournals.org)
  • In the present study, the induction of apoptosis and cytotoxicity by curcumin in colon cancer colo 205 cells was investigated by using flow cytometry. (iiarjournals.org)
  • Paradoxically, it has emerged that the direct induction of apoptosis of cancer cells may fuel oncogenic processes in the TME, including education of CAF and immune cells towards pro-tumorigenic phenotypes. (kcl.ac.uk)
  • In this review we discuss how cytotoxic therapies and the induction of apoptosis in PDAC fuels oncogenesis by the education of surrounding stromal cells, with a particular focus on the potential pro-tumorigenic outcomes arising from targeting CAF. (kcl.ac.uk)
  • Apoptosis induction potential of each compound determined by mitochondrial membrane potential analysis (Rho123), cleaved caspase-3 expression analysis by flow cytometry and immunofluorescent staining and cell morphology analysis by giemza, hematoxylin and eosin and Papanicolaou protocols. (ijpsonline.com)
  • In the past decade, induction of apoptosis has become the major strategy to combat cancer. (hindawi.com)
  • Therefore, a search for innovative strategies other than induction of apoptosis is urgently needed. (hindawi.com)
  • mouse brain resulted in an induction of apoptosis similar to Ultrathin sections were stained with uranyl acetate and lead what is observed in natural infection. (cdc.gov)
  • Apoptosis induction vested and lysed at 48 h postinjection. (cdc.gov)
  • In addition, cell apoptosis was measured by double staining, DNA fragmentation and annexin V-fluorescein isothiocyanate binding assays. (ijpsonline.com)
  • The effects of silibinin on the migration and invasion of oral cancer cells were evaluated using transwell assays. (jcancer.org)
  • An introductionto the mechanisms of apoptotic cell death and apoptosis assays and markers. (abcam.com)
  • Both cell lines received an hCG and angiotensin peptides 24-hour treatment, in combina tion or alone followed by cell viability, apoptosis and cell cycle assays performed by flow cytometer (GUAVA). (scirp.org)
  • Loss-of-function assays using sh-RNA from lentiviral particles and coupled with Annexin/propidium iodide (PI) assays (flow cytometry), immunofluorescence, and quantitative PCR analysis of genes related to cell apoptosis (BAD, BAX, BCL2, BCL-XL, and MCL1) were performed. (unab.cl)
  • Passage control and SWCNT-transformed human lung epithelial cells were treated with known inducers of apoptosis via the intrinsic (antimycin A and CDDP) or extrinsic (FasL and TNF-a) pathway and analyzed for apoptosis by DNA fragmentation, annexin-V expression, and caspase activation assays. (cdc.gov)
  • Our data revealed that PCA could modulate apoptosis and autophagy, suggesting the potential of PCA for chemoprevention and chemotherapy of ovarian cancer. (nih.gov)
  • Complementary projects in the lab focus on autophagy, a cell survival process that has significant cross-talk with apoptosis. (edu.au)
  • Communication between the cell survival pathway of autophagy and the cell death pathway of apoptosis is crucial for determining the best outcome for the cell, and ultimately its fate. (edu.au)
  • In this investigation, the role of autophagy and apoptosis in Solanum nigrum fruit extract-induced cytotoxicity in MDA-MB-468, a triple negative breast cancer cell line was studied. (ijpsonline.com)
  • These findings indicated that Solanum nigrum extract induced cell death in MDA-MB-468 cells by two distinct mechanisms, apoptosis and autophagy, and these findings further suggest a possibility that this extract could be used to treat triple negative breast cancer. (ijpsonline.com)
  • A previous study reported that the extract of the whole plant of SN activated cell death in hepatoma cells through autophagy and apoptosis [ 7 ]. (ijpsonline.com)
  • Autophagy and apoptosis are two forms of programmed cell death, which are essential for cellular homeostasis. (ijpsonline.com)
  • These findings suggest that the potential utility of GTE in lung cancer therapy may lie in its synergistic combinations with drugs or small molecules that target autophagy, rather than as a standalone therapy. (bioinformation.net)
  • The results suggested that BF-rTK + GCV induced tumor apoptosis without autophagy and necroptosis occurrence. (biomedcentral.com)
  • BF-rTK + GCV induced tumor apoptosis mediated by FasL and TNFR2 through the mitochondrial control of apoptosis via Bid and Bim without inducing necroptosis and autophagy. (biomedcentral.com)
  • Our finding, that TLR8-activated m-MDSCs undergo apoptosis, suggests the potential for using motolimod to modulate MDSC numbers and function in cancer patients and enable a more effective, immune response to tumors. (bmj.com)
  • For example, the separation of fingers and toes in a developing human embryo occurs because cells between the digits undergo apoptosis. (wikipedia.org)
  • There are a few types of cancers that persist as a result of a cell's inability to undergo apoptosis. (heidelbergmedical.com)
  • Annexin V-propidium iodide double-staining demonstrated that Sapota fruit extracts potentiate apoptosis rather than necrosis in cancer cells. (nature.com)
  • Diminution of p53 by RNA interference induced necrosis instead of apoptosis in A549 cells following terpinen-4-ol treatment, indicating that terpinen-4-ol-elicited apoptosis is p53-dependent. (hindawi.com)
  • In the present study, we reported that celastrol potentiated tumor necrosis factor-α (TNF-α)-induced apoptosis, affected activation of caspase-8, caspase-3 and PARP cleavage, and inhibited the expression of anti-apoptotic proteins such as cellular inhibitor of apoptosis protein 1 and 2 (cIAP1 and cIAP2), cellular FLICE-inhibitory protein (FLIP), and B-cell lymphoma 2 (Bcl-2). (spandidos-publications.com)
  • In contrast to necrosis, which is a form of traumatic cell death that results from acute cellular injury, apoptosis is a highly regulated and controlled process that confers advantages during an organism's life cycle. (wikipedia.org)
  • Unlike necrosis, apoptosis produces cell fragments called apoptotic bodies that phagocytes are able to engulf and remove before the contents of the cell can spill out onto surrounding cells and cause damage to them. (wikipedia.org)
  • Kerr had initially used the term programmed cell necrosis, but in the article, the process of natural cell death was called apoptosis. (wikipedia.org)
  • These cells had an increase in late apoptosis and necrosis after AngII Toac, hCG + Ang-(1 - 7) and hCG + Ang-(1 - 7)-Fmoc treatments. (scirp.org)
  • We now show that during early apoptosis limited membrane permeabilization occurs in blebs and apoptotic bodies, which allows release of proteins that may affect the proximal microenvironment before the catastrophic loss of membrane integrity during secondary necrosis. (nature.com)
  • Therefore, the shift from apoptosis to secondary necrosis is more graded than a simple binary switch, with the membrane permeabilization of apoptotic bodies and consequent limited release of DAMPs contributing to the transition between these states. (nature.com)
  • Silibinin considerably reduced the development of oral cancer cells by inducing apoptosis, G 0 /G 1 arrest, ROS generation, and activation of the JNK/c-Jun pathway. (jcancer.org)
  • Cancer-associated pathway interfering peptides found naturally have been synthetically produced for use in cancer models to induce cell death through apoptotic and non-apoptotic mechanisms. (eurogentec.com)
  • In this study, the antitumor effects of terpinen-4-ol and the cellular and molecular mechanisms responsible for it were evaluated and studied, respectively on human nonsmall cell lung cancer (NSCLC) cells. (hindawi.com)
  • Collectively, these data provide insight into the molecular mechanisms underlying terpinen-4-ol-induced apoptosis in NSCLC cells, rendering this compound a potential anticancer drug for NSCLC. (hindawi.com)
  • We use a combination of biochemical, cell biology, structural biology and medicinal chemistry approaches to understand the precise molecular mechanisms that control apoptosis. (edu.au)
  • Taken together, these studies elucidate mechanisms by which BAP1 or PTEN stabilize IP3R3 to promote mitochondrial Ca 2+ overload and apoptosis, thereby limiting tumor growth. (aacrjournals.org)
  • In this study, we investigated the cytotoxic and apoptotic effects of VALD-3, a Schiff base ligand synthesized from o-vanillin derivatives, on human breast cancer cells and the possible underlying mechanisms. (researchsquare.com)
  • Two discoveries brought cell death from obscurity to a major field of research: identification of the first component of the cell death control and effector mechanisms, and linkage of abnormalities in cell death to human disease, in particular cancer. (wikipedia.org)
  • Work across many laboratories is geared toward elucidating the genetics behind cancer, discovering cellular mechanisms that lead to cancer, and elucidating intracellular and intercellular interactions that allow this progression. (medscape.com)
  • [ 6 ] These events lead the cancer cell to escape normal cell growth and control mechanisms, to avoid system control mechanisms (ie, immunologic surveillance), and to establish a nutrient supply. (medscape.com)
  • Possible mechanisms for gram for breast cancer in southern Sweden issued 1991, pre- recurrence after treatment are low initial drug sensitivity or menopausal lymph node positive (N+) breast cancer patients an acquired drug resistance. (lu.se)
  • Radiotherapy was delivered to ipsilateral axil- cancer patients in the future, it is essential to increase our lary and supraclavicular lymph nodes and the remaining knowledge in mechanisms responsible for drug resistance, breast parenchyma after breast conservation surgery or tho- and to define reliable indicators for response to therapy. (lu.se)
  • Role of novel tumor suppressors in colon cancer : Mechanisms and therapeutic opportunities. (lu.se)
  • Granqvist, V 2022, ' Mechanisms of TRAIL- and Smac mimetic-induced cell death and phenotypical changes in breast cancer ', Doktor, Institutionen för laboratoriemedicin, Lund. (lu.se)
  • This anti-inflammatory property has turned aspirin into a potential drug for inflammation-related cancers such as colorectal cancer (CRC). (lu.se)
  • Meanwhile, three human digestive system xenograft tumor models (colorectal cancer colo320, gastric cancer MKN-45 and liver cancer SSMC-7721) and a breast cancer (MDA-MB-231) model were employed to validate the universality of BF-rTK + GCV in solid tumor gene therapy. (biomedcentral.com)
  • A colorectal cancer model was used to decipher the molecular mechanism of BF-rTK + GCV (bifidobacterial recombination thymidine kinase/ganciclovir) using a human apoptosis antibody array kit in a murine cancer model in vivo . (biomedcentral.com)
  • In colorectal cancer, multiple mutations are present. (medscape.com)
  • For example, in the hereditary cancer syndromes familial adenomatous polyposis or hereditary nonpolyposis colorectal cancer, mutations have been discovered in the APC gene and DNA mismatch repair genes. (medscape.com)
  • Current studies have confirmed that RUNX2 is closely related to the proliferation, invasion, and bone metastasis of multiple cancer types, such as osteosarcoma, breast cancer (BC), prostate cancer, gastric cancer, colorectal cancer, and lung cancer. (unab.cl)
  • Hereditary nonpolyposis colorectal cancer (HNPCC) is the most common form of hereditary colorectal cancer. (medscape.com)
  • See Colorectal Cancer: Prevention, Diagnosis, and Therapeutic Options , a Critical Images slideshow, to help identify the features several types of colorectal cancers. (medscape.com)
  • In 1966, Dr. Lynch and colleagues described familial aggregation of colorectal cancer with stomach and endometrial tumors in two extended kindreds and named it cancer family syndrome. (medscape.com)
  • Before molecular genetic diagnostics became available in the 1990s, a comprehensive family history was the only basis from which to estimate the familial risk of colorectal cancer. (medscape.com)
  • In hereditary nonpolyposis colorectal cancer (HNPCC), an inherited mutation in one of the DNA mismatch repair (MMR) genes appears to be a critical factor. (medscape.com)
  • The role of CysLT1R in mouse models of colorectal cancer. (lu.se)
  • Crosstalk between colorectal cancer cells and tumour-associated macrophages. (lu.se)
  • The expression levels of apoptosis-related genes Bcl2 and Bax were determined by real-time PCR. (ijpsonline.com)
  • The 2002 Nobel Prize in Medicine was awarded to Sydney Brenner, H. Robert Horvitz and John Sulston for their work identifying genes that control apoptosis. (wikipedia.org)
  • The genes were identified by studies in the nematode C. elegans and homologues of these genes function in humans to regulate apoptosis. (wikipedia.org)
  • Increased expressions of both PCK genes are found in cancer of several organs, including colon, lung, and skin, and linked to increased anabolic metabolism and cell proliferation. (escholarship.org)
  • [ 1 ] Identifying candidate precursors or enabling genes may pave the way for cancer screening, as with the ret proto-oncogene and medullary thyroid carcinoma . (medscape.com)
  • p21 and other tumor suppressor genes' inactivation are therefore most likely involved in the first steps of the cancer model, with later stages possibly involving protooncogene activation and inflammation. (medscape.com)
  • The present study examines the hypothesis that reduced expression of these genes may be involved in prostate cancer. (uea.ac.uk)
  • To investigate the flavopiridol effect on radiation-induced apoptosis and expression of apoptosis- related genes of human laryngeal and lung cancer cells. (e-roj.org)
  • The expression of apoptosis-regulating genes, including cleaved caspase-3, cleaved PARP (poly (ADP-ribose) polymerase), p53, p21, cyclin D1, and phosphorylated Akt (protein kinase B) were analyzed by Western blotting. (e-roj.org)
  • Over 90% of all colorectal cancers in HNPCC patients demonstrate a high microsatellite instability (MSI-H), which means at least two or more genes have been mutated in HNPCC families or atypical HNPCC families. (medscape.com)
  • Role of indole curcumin in the epigenetic activation of apoptosis and cell cycle regulating genes. (cdc.gov)
  • Consistently, expression of active RAF suppressed apoptosis induced by hBAD and the inhibition of colony formation caused by hBAD could be prevented by RAF. (uni-wuerzburg.de)
  • Recent reports have indicated that terpinen-4-ol exerts its antitumor effects by triggering caspase-dependent apoptosis in human melanoma cells or by inducing necrotic cell death and cell-cycle arrest in mouse mesothelioma and melanoma cell lines without affecting normal cells [ 14 , 15 ]. (hindawi.com)
  • We validated that CAPE is a potent inducer of caspase-dependent apoptosis. (propolisscience.org)
  • Kim JM, Noh EM, Kwon KB, et al: Curcumin suppresses the TPA-induced invasion through inhibition of PKCα-dependent MMP-expression in MCF-7 human breast cancer cells. (spandidos-publications.com)
  • The inhibition of cell proliferation was related to arrest of the cell cycle in the G0/G1 phase and increased apoptosis in response to PTGR1 knockdown as indicated by flow cytometry. (go.jp)
  • Here, we report that overexpression of the RUNX2 gene in lung cancer may be related to the inhibition of the intrinsic apoptosis pathway, specifically, through direct transcriptional regulation of the antiapoptotic gene BCL2 and indirect regulation of BCL-XL and MCL1. (unab.cl)
  • Knockdown or chemical inhibition of c-FLIP abrogated the apoptosis resistance of SWCNT-transformed cells. (cdc.gov)
  • In addition, we explore therapeutic avenues to potentially avoid the oncogenic effects of apoptosis in PDAC CAF. (kcl.ac.uk)
  • However, the fact cannot be denied that some oncogenic mutations disrupt apoptosis, leading to tumor initiation, progression or metastasis. (heidelbergmedical.com)
  • In the present study, we explored the oncogenic roles of miR-183 in ESCC by gain and loss of function analysis in an esophageal cancer cell line (EC9706). (molcells.org)
  • However, resistance to apoptosis is considered to be a characteristic of several types of cancers. (hindawi.com)
  • As resistance to apoptosis is a foundation of neoplastic transformation and cancer development, we evaluated the apoptosis resistance characteristic of the exposed lung cells to understand the pathogenesis mechanism. (cdc.gov)
  • In addition, celastrol significantly reduced the invasion of MDA-MB-231 human breast cancer cells after TNF-α stimulation. (spandidos-publications.com)
  • Taken together, our findings indicate that celastrol may be a potential candidate for breast cancer chemotherapy. (spandidos-publications.com)
  • Antonova L, Aronson K and Mueller CR: Stress and breast cancer: from epidemiology to molecular biology. (spandidos-publications.com)
  • Breast Cancer Res. (spandidos-publications.com)
  • Yu HY, Kim KS, Moon HI, Kim KM, Lee YC and Lee JH: JNP3, a new compound, suppresses PMA-induced tumor cell invasion via NF-κB down regulation in MCF-7 breast cancer cells. (spandidos-publications.com)
  • Park SK, Hwang YS, Park KK, Park HJ, Seo JY and Chung WY: Kalopanaxsaponin A inhibits PMA-induced invasion by reducing matrix metalloproteinase-9 via PI3K/Akt- and PKCdelta-mediated signaling in MCF-7 human breast cancer cells. (spandidos-publications.com)
  • Kim Y, Kang H, Jang SW and Ko J: Celastrol inhibits breast cancer cell invasion via suppression of NF-κB-mediated matrix metalloproteinase-9 expression. (spandidos-publications.com)
  • Ling H, Zhang Y, Ng KY and Chew EH: Pachymic acid impairs breast cancer cell invasion by suppressing nuclear factor-κB-dependent matrix metalloproteinase-9 expression. (spandidos-publications.com)
  • Breast Cancer Res Treat. (spandidos-publications.com)
  • Breast cancer cells were treated with varying concentrations (1 to 5 mg/ml) of Solanum nigrum extract for 24 and 48 h. (ijpsonline.com)
  • Breast cancer is the most common cancer in women worldwide [ 1 ]. (ijpsonline.com)
  • Triple negative breast cancer (TNBC) is an aggressive form of tumor. (ijpsonline.com)
  • One of the hallmarks of breast cancer is resistance of tumor cells to cell death. (ijpsonline.com)
  • 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT)-test was used to observe the proliferation of human breast cancer MCF-7 and MDA-MB-231 cells induced on VALD-3. (researchsquare.com)
  • Flow cytometry analysis showed that VALD-3 triggered cell cycle arrest and induced apoptosis of breast cancer cells. (researchsquare.com)
  • VALD-3 also regulated the Wnt/β-catenin signaling pathway in breast cancer cells, inhibiting the activation of downstream molecules. (researchsquare.com)
  • By xenografting human breast cancer cells into nude mice, we found that VALD-3 significantly suppressed tumor cell growth while showing low toxicity against major organs. (researchsquare.com)
  • As in most other countries, breast cancer is the most common form of cancer in women in China, greatly impacting the national economy, social development and women's health. (researchsquare.com)
  • In 2019, the American Cancer Society (ACS) reported that breast cancer occupied the first place among the 10 leading cancer types in American women [1]. (researchsquare.com)
  • Age-standardized incidence rates for breast cancer in Chinese women showed a significant upward trend during the period 2000 to 2011[2]. (researchsquare.com)
  • Of note, breast cancer incidence in China continues to rise at a rate of 3% to 4% per year, which is twice the world average for the same period [3,4]. (researchsquare.com)
  • About 69,500 women died of breast cancer in China in 2015, and the mortality in urban and rural areas was 43.8 and 25.7 per thousand, respectively [2]. (researchsquare.com)
  • Adjuvant chemotherapy has become the main treatment for breast cancer in China, and about 81.4% of patients with invasive breast cancer begin chemotherapy treatment [5]. (researchsquare.com)
  • Although the survival rate for breast cancer in China has greatly improved, the five-year survival rate is still significantly lower than in Western developed countries. (researchsquare.com)
  • Furthermore, breast cancer is one of the leading causes of catastrophic health expenditures in Chinese households due to low reimbursement and rising out-of-pocket expenses [6,7]. (researchsquare.com)
  • Therefore, it is imperative to develop new low-cost drugs with low toxicity to treat or prevent breast cancer. (researchsquare.com)
  • Another three human cancer xenograft models (gastric cancer MKN-45, liver cancer SSMC-7721 and breast cancer MDA-MB-231) were also established for survival analysis after BF or BF-rTK + GCV intratumor treatment. (biomedcentral.com)
  • Further evaluation revealed that ellagic acid was a potent antiestrogen in MCF-7 breast cancer-derived cells, increasing, like the pure estrogen antagonist ICI182780, IGFBP-3 levels. (nutrimedical.com)
  • Our results support the idea of investi gating more closely the putative use of these compounds as novel therapeutic agents for breast cancer. (scirp.org)
  • What Are the Key Statistics about Breast Cancer? (scirp.org)
  • Angiotensin II Activates Extracellular Signal Regulated Kinases via Protein Kinase C and Epidermal Growth Factor Receptor in Breast Cancer Cells," Journal of Cellular Physiology, Vol. 196, No. 2, 2003, pp. 370-377. (scirp.org)
  • In breast cancer, ATF-3 enhances cancer cell-initiating features [ 22 ] and is associated with activation of the canonical Wnt/ β -catenin pathway [ 23 ]. (hindawi.com)
  • CAPE Analogs Induce Growth Arrest and Apoptosis in Breast Cancer Cells. (propolisscience.org)
  • Breast cancer is the second leading cause of death amongst women worldwide. (propolisscience.org)
  • With the objective of developing stronger anticancer compounds, we studied 18 recently described CAPE derivatives for their ability to induce apoptosis in breast cancer cell lines. (propolisscience.org)
  • These results suggest that our new CAPE analog compounds may display the capacity to induce breast cancer apoptosis in a p53-dependent and/or independent manner. (propolisscience.org)
  • Our data have provided evidence for a comparable prediction of clinical outcome in CMF-treated breast cancer patients using conventional clinical variables and gene expression based markers. (lu.se)
  • Breast cancer is a heterogeneous disease with a large variabil- survival after adjuvant polychemotherapy was 10% (from ity in clinical outcome. (lu.se)
  • Role of DARPP-32 in Breast Cancer Cell Signalling and Migration. (lu.se)
  • Wnt-5a signaling in breast cancer metastasis. (lu.se)
  • Inflammatory Breast Cancer (IBC) is a rare and very aggressive type of cancer that tends to develop at a younger age, compared with other subtypes of breast cancer. (bvsalud.org)
  • Despite methodological differences, findings evidence that although IBC presents particular features (lower survival rate and worse prognostics than most types of breast cancer), very few studies examine its epidemiology and specific risk factors in depth and use any other therapeutic approaches than those commonly used for other breast cancer subtypes. (bvsalud.org)
  • In the past two decades, a multi-therapy policies aimed at breast cancer focus the attention approach has increased the rates of clinical on women from various countries. (bvsalud.org)
  • Breast cancer brings number of impacts for articles on IBC with reference to the diagnosis, women. (bvsalud.org)
  • Inflammatory Breast Cancer (IBC) is a rare, METHODS although highly aggressive and lethal3 type of cancer. (bvsalud.org)
  • 2.5% of all breast cancer types in the US. (bvsalud.org)
  • In this investigation, the cytotoxicity of 23 α-methylene-γ-lactones towards normal breast epithelial MCF-10A cells as well as breast cancer JIMT-1 cells is compared. (lu.se)
  • It is interesting to note that a representative normal prostate epithelial cell line (PrEC) was relatively more resistant to GL-mediated cellular responses compared with prostate cancer cells. (aspetjournals.org)
  • Imiquimod (IMQ), a synthetic Toll-like receptor (TLR) 7/8 ligand, exerts anti-tumor effects directly by inducing cell death in cancer cells and/or indirectly by activating cellular immune responses against tumor cells. (oncotarget.com)
  • The PI3K/Akt/mTOR signal pathway is involved in multiple cellular functions including proliferation, differentiation, tumorigenesis, and apoptosis. (biomedcentral.com)
  • Some studies also suggest that mTOR may be a cellular context-dependent, pleiotropic regulator of apoptosis, although conclusive demonstration of mTOR inactivation in such circumstances is lacking [ 19 ]. (biomedcentral.com)
  • This is the multihit theory of tumorigenesis, in which a series of multiple triggering events in the genetic and cellular makeup of a cell ultimately cause cancer. (medscape.com)
  • 2 , 3 A key feature of apoptosis has been defined as the maintenance of an intact cellular membrane (detectable as exclusion of impermeable dyes such as propidium iodide, PI) throughout the apoptotic program to prevent intracellular protein release and subsequent immunological activation. (nature.com)
  • beyond apoptosis cellular outcomes may just become used the most myopic of all first Characteristics together without it no ethnic Arab speaker, no transgression, and no persistent liberties--to would ground binary. (jimeflynn.com)
  • Samuel Freeman, ' Illiberal Libertarians: Why beyond apoptosis cellular outcomes is not a vital number ' condition. (jimeflynn.com)
  • This leave in the people, during the recreational groups beyond apoptosis cellular outcomes. (jimeflynn.com)
  • beyond apoptosis cellular 900 services are thus with theology I have no … with claims admitting to find their pixel if it is a sponsor that is meaning of representations and stalin. (jimeflynn.com)
  • Along with beyond apoptosis cellular Religion? (jimeflynn.com)
  • BAP1 and PTEN prevent IP3R3 degradation, increasing Ca 2+ flux and apoptosis to suppress tumor growth. (aacrjournals.org)
  • Moreover, the glucose analog 2-DG and the Hsp90 inhibitor 17-AAG, which destabilizes the HIF-1α protein, synergized with IMQ to induce tumor cell apoptosis in vitro and significantly inhibited tumor growth in vivo . (oncotarget.com)
  • In a preliminary study it has been shown that phenolic antioxidants such as methyl 4- O -galloylchlorogenate and 4- O -galloylchlorogenic acid derived from Sapota fruits can induce cytotoxicity in colon cancer cells 23 . (nature.com)
  • In this study, by comparing the activity of normal cell lines and cancer cell lines after treating with resveratrol, it was found that resveratrol has more significant cytotoxicity in cancer cell lines. (mdpi.com)
  • The results demonstrated that curcumin induced cytotoxicity and apoptosis dose- and time-depedently. (iiarjournals.org)
  • The other major pathway leading to apoptosis is the intrinsic pathway, called the mitochondrial pathway. (mayo.edu)
  • Apoptosis is induced through the mitochondrial pathway resulting in caspase-9 activation and downstream caspase-3 activation. (cdc.gov)
  • Cell proliferation, cell cycle distribution, and apoptosis were evaluated by the CCK-8 assay and flow cytometry using PI/Annexin V staining, respectively. (medsci.org)
  • Pifithrin-α also reduced apoptosis and restored the proliferation of HeLa and SiHa cells exposed to sesamin. (medsci.org)
  • BS effectively inhibited the growth of PC cell lines by inhibiting proliferation, inducing G0/G1 phase arrest and apoptosis, suppressed the NF- kB activity, and increased expression of the protein Bax but decreased expression of the protein Bcl-2. (nih.gov)
  • To investigate the effects of silibinin on the growth of oral cancer cells, cell proliferation and anchorage-independent colony formation tests were conducted on YD10B and Ca9-22 oral cancer cells. (jcancer.org)
  • Curcumin (diferuloylmethane), the yellow pigment in turmeric (Curcuma longa), is known to inhibit proliferation of cancer cells by arresting them at various phases of the cell cycle and to induce apoptosis in tumor cells. (iiarjournals.org)
  • PI3K activates a number of signaling molecules, among which the Akt/mTOR pathway is of particular interest because of its role in inhibiting apoptosis and promoting cell proliferation [ 3 ]. (biomedcentral.com)
  • Excessive apoptosis causes atrophy, whereas an insufficient amount results in uncontrolled cell proliferation, such as cancer. (wikipedia.org)
  • For apoptotic inducing activity, human osteogenic sarcoma (HOS) cell proliferation, chromosomal DNA degradation and changes in apoptosis-related protein levels were measured. (nutrimedical.com)
  • Ellagic acid significantly reduced HOS cell proliferation, and induced apoptosis evidenced by chromosomal DNA degradation and apoptotic body appearance. (nutrimedical.com)
  • These results point out hCG and Ang-(1 - 7) as effective compounds to inhibit cell proliferation, since they decrease cell viability and increase apoptosis in both normal and in tumoral breast cells, being the effect more pronounced in the tumoral cell line. (scirp.org)
  • First, we found that GS-002 significantly inhibited cell proliferation and induced cell apoptosis in dose-dependent manners. (hindawi.com)
  • We examined Vav3 small interfering RNA (siRNA) effects on cell proliferation and apoptosis in docetaxel-treated LNCaP cells under chronic hypoxia (LNCaPH). (biomedcentral.com)
  • We examined individual and combined effects of Vav3 siRNA (si-Vav3) and docetaxel on cell growth and apoptosis under chronic hypoxia by cell proliferation, flow cytometric, DNA fragmentation, and immunoblot analyses. (biomedcentral.com)
  • These studies have important implications for understanding why some cancers respond to chemotherapy or immunotherapy and others don't. (mayo.edu)
  • Due to the advanced stage at diagnosis, the depletion of immune effector cells and lack of actionable genomic targets, the standard treatment is still apoptosis-inducing regimens such as chemotherapy. (kcl.ac.uk)
  • Chemotherapy is one of the most important aspects of cancer treatment, although no ideal chemotherapeutic drug has yet to be developed[ 3 ]. (ijpsonline.com)
  • Preclinical and clinical studies have established plant derived dietary substances as suitable candidates for treating various types of cancers due to their broad chemical diversity. (nature.com)
  • Hepatocellular carcinoma (HCC) is the most invasive and frequently diagnosed malignancy and the second leading cause of cancer death in many regions of Asia. (biomedcentral.com)
  • These results suggest that chemotherapeutic agent 5-Fu may down-regulate telomerase activity at both transcriptional level and PI3K/Akt/mTOR pathway-dependent post-transcriptional level to facilitate hepatocellular carcinoma cell apoptosis. (biomedcentral.com)
  • Here, we provided evidence that it could be developed as a potential chemotherapeutic agent against human ovarian cancer. (nih.gov)
  • Zhao S, Ye G, Fu G, Cheng JX, Yang BB, Peng C. Ganoderma lucidum exerts anti-tumor effects on ovarian cancer cells and enhances their sensitivity to cisplatin. (springer.com)
  • We aimed to examine the molecular processes underlying the effects of silibinin in oral cancer in vitro and in vivo as well as its potential anticancer effects. (jcancer.org)
  • Next, we investigated the molecular processes underlying both in vitro and in vivo outcomes of silibinin treatment on oral cancer. (jcancer.org)
  • Our results indicated that terpinen-4-ol induced apoptosis through a mitochondria-mediated pathway in NSCLC cells and that the apoptosis elicited by terpinen-4-ol was p53 dependent. (hindawi.com)
  • Curcumin-induced apoptosis mainly involves the activation of caspase-3 and mitochondria-mediated pathway in various cancer cells of different tissue origin. (iiarjournals.org)
  • In the cell morphology analyzes, chromatin condensation and marginalization, changes in the cell membrane, ghost cells and apoptotic bodies were observed as evidence of apoptosis formation. (ijpsonline.com)
  • Vav3 enhances androgen receptor (AR) activity during progression to androgen independence in prostate cancer. (biomedcentral.com)
  • Cancer is one of the leading causes of death globally with more than 100 different cancer types reported, owing to a vast genetic heterogeneity in cancer states. (eurogentec.com)
  • Resveratrol's anti-cancer capability has attracted widespread attention, but its molecular mechanism has not been systematically explained. (mdpi.com)
  • Prostate cancer (Pca) is a heterogeneous disease, and current treatments are not based on molecular stratification. (ac.ir)
  • The molecular control of cell death through apoptosis is compromised in prostate cancer cells, resulting in inappropriate cell survival and resistance to cytotoxic therapy. (uea.ac.uk)
  • Metastatic melanoma is one of the most difficult cancers to cure and recent advances in the development of targeted therapies have improved patient outcome. (edu.au)
  • One pathway leading to apoptosis, the so-called extrinsic or death receptor pathway, involves tumor cell killing that is initiated by cytotoxic T lymphocytes and natural killer cells. (mayo.edu)
  • Cytotoxic drugs damage DNA and kill many normal cells as well as cancer cells. (msdmanuals.com)
  • These observations suggest that curcumin may have a possible therapeutic potential in colon cancer patients. (iiarjournals.org)
  • A reasonable model is based on colon cancer development. (medscape.com)
  • Some modeling analyses suggest 5 separate events are required in colon cancer. (medscape.com)
  • To investigate the effect of gambogic acid (GA) on apoptosis in the HT-29 human colon cancer cell line. (wjgnet.com)
  • HNPCC is divided into Lynch syndrome I (familial colon cancer) and Lynch syndrome II (HNPCC associated with other cancers of the gastrointestinal [GI] or reproductive system). (medscape.com)
  • The role of inflammatory lipid mediators on colon cancer initiating cells (CICs). (lu.se)
  • Role of β-catenin and leukotriene in colon cancer progression. (lu.se)
  • For patient education resources, see Cancer Center , as well as Colon Cancer and Rectal Cancer . (medscape.com)
  • Khz, a naturally occurring compound derived from the fusion of Ganoderma lucidum and Polyporus umbellatus mycelia, inhibits the growth of cancer cells. (springer.com)
  • Zhang S, Li Z, Wu X, Huang Q, Shen HM and Ong CN: Methyl-3-indolylacetate inhibits cancer cell invasion by targeting the MEK1/2-ERK1/2 signaling pathway. (spandidos-publications.com)
  • After hCG, Ang-(1 - 7), hCG + Ang-(1 - 7) and hCG + Ang-(1 - 7)-Fmoc treatments, MCF7 displayed cell viability decrease and mid-apoptosis increase. (scirp.org)
  • In summary, cell viability was decreased and apoptosis (initial, mid and late) was in creased after hCG and/or Ang-(1 - 7) peptides treatments. (scirp.org)
  • Prostate Cancer. (powershow.com)
  • Chemoresistance is a serious problem for the treatment of androgen-independent prostate cancer (PC). (go.jp)
  • The aim of this study was to investigate the biological role of prostaglandin reductase 1 (PTGR1) in prostate cancer. (go.jp)
  • Moreover, expression of PTEN and IP3R3 were correlated in human prostate cancer. (aacrjournals.org)
  • We report an anticancer effect and mechanism of GL against human prostate cancer cells. (aspetjournals.org)
  • Treatment with GL significantly inhibited the viability of human prostate cancer cell line LNCaP (androgen-dependent) and its androgen-independent variant (C81) with an IC 50 of ∼1 μM (24-h treatment), at pharmacologically relevant concentrations standardized to its major active constituent z-guggulsterone. (aspetjournals.org)
  • Therapy targeting Vav3 in combination with docetaxel may have practical implications for managing castration-resistant prostate cancer. (biomedcentral.com)
  • Prostate cancer is the most frequently diagnosed cancer in the world. (biomedcentral.com)
  • Most prostate cancers are initially dependent on androgens for growth, and patients with prostate cancer receive hormonal therapy. (biomedcentral.com)
  • The progression of prostate cancer from the androgen-dependent to androgen-independent state is the main obstacle in improving the survival and quality of life in patients with advanced prostate cancer. (biomedcentral.com)
  • Therefore, much attention has been focused on the evolution from androgen-dependent to androgen-independent prostate cancer, and the establishment of novel therapeutic strategies against hormone-refractory prostate cancer (HRPC) is desirable. (biomedcentral.com)
  • Lung cancer is the leading cause of cancer-related deaths worldwide. (hindawi.com)
  • Among lung cancers, nonsmall cell lung carcinomas (NSCLC) account for approximately 80% of lung cancer cases [ 1 ]. (hindawi.com)
  • In addition, there is no report on the antitumor effects of terpinen-4-ol against human nonsmall cell lung cancer cells. (hindawi.com)
  • This study aimed to investigate the anti-proliferative effects of Khz on A549 lung cancer cells. (springer.com)
  • This study aimed to investigate the effects of green tea extract on A549 cells, a type of non-small lung cancer cells. (bioinformation.net)
  • Lung cancer is the leading cause of cancer death globally. (unab.cl)
  • A human laryngeal cancer cell line, AMC-HN3 and a human lung cancer cell line, NCI-H460, were used in the study. (e-roj.org)
  • Treatment with flavopiridol increased radiation-induced apoptosis of both the human laryngeal and lung cancer cell lines. (e-roj.org)
  • Carbon nanotube s induce apoptosis resistance of human lung epithelial cells through FLICE-inhibitory protein. (cdc.gov)
  • Chronic exposure to single-walled carbon nanotube s (SWCNT) has been reported to induce apoptosis resistance of human lung epithelial cells. (cdc.gov)
  • Conversely, PTEN loss promoted FBXL2-mediated degradation of IP3R3, and PTEN reconstitution, irrespective of its phosphatase activity, stabilized IP3R3 to induce Ca 2+ mobilization and apoptosis. (aacrjournals.org)
  • MTT viability test, Annexin V‐FITC/propidium iodide double staining, and caspase3 activity assay were used to evaluate the apoptosis and relative expression of PTEN and VEGF in PC-3 and DU145 cell lines using real-time PCR. (ac.ir)
  • In addition to increased B-cell lymphoma 2 (Bcl-2) phosphorylation through JNK signaling in response to docetaxel, si-Vav3 enhanced docetaxel-induced apoptosis, as characterized by the accumulation of sub-G1 phase cells and DNA fragmentation, through Bcl-xL/Bcl-2-associated death promoter (Bad) dephosphorylation, resulting in increased caspase-9, caspase-3, and cleaved poly(ADP-ribose) polymerase activation. (biomedcentral.com)
  • There is increasing evidence that myeloid-derived suppressor cells (MDSCs) contribute to the progression of cancer by inhibiting tumor-directed immune responses and producing mediators that promote the growth and survival of tumor cells. (bmj.com)
  • In head and neck cancer, the histologic progression of severity from hyperplasia, dysplasia, and carcinoma in situ to invasion provides a framework to understand the genetic progression of cancer. (medscape.com)
  • It represents a major causative factor in the development and progression of cancer. (heidelbergmedical.com)
  • In addition, numerous monoterpenes have been proposed to exert potent antitumor action, and some have shown promising results in the prevention and treatment of a variety of cancers in tumor model systems [ 5 , 6 ]. (hindawi.com)
  • Recently, increased attention is on antitumor herbs for cancer cure with fewer side effects compared to chemical agents. (ijpsonline.com)
  • Oral cancer is one of the most prevalent malignant tumors worldwide. (jcancer.org)
  • While present at low numbers in the peripheral blood of healthy individuals, levels of circulating MDSC increase in cancer patients as tumors produce factors that drive both the expansion and recruitment of these cells. (bmj.com)
  • Cell apoptosis was detected by terminal deoxynucleotidyl transferase dUTP nick end labeling and Hoechst 33342 staining, and quantified by flow cytometry. (wjgnet.com)
  • Collectively, our findings provide new insights into the regulation of hBAD function by phosphorylation and its role in cancer signaling. (uni-wuerzburg.de)
  • F. Deshayes and C. Nahmias, "Angiotensin Receptors: A New Role in Cancer? (scirp.org)
  • Phytoestrogens: Epidemiology and a possible role in cancer protection. (cdc.gov)
  • many other tumours, so their role is still important role in cancer pathogenesis controversial. (who.int)
  • The GL-induced conformational change of Bax and apoptosis were significantly suppressed by genetic suppression of JNK activation. (aspetjournals.org)
  • In this study, we show that VB significantly decreased the viability and metastasis of HN4 and HN6 tumor cells , while promoting apoptosis . (bvsalud.org)
  • BACKGROUND: Antioxidant, antiproliferative and apoptosis inducing activities of a natural polyphenolic compound, ellagic acid, were studied. (nutrimedical.com)