Cancer antigen antigen immunotherapy adoptive. Medical search. Frequent questions

This serves as a guidepost for rationally designing new combination checkpoint therapies, downstream T cell receptor (TCR) isolation, cancer antigen identification and molecular characterization of naturally occurring tumor-reactive T cells in human cancer. (upenn.edu)
Chimeric antigen receptor (CAR) T-cell therapy is a rapidly growing treatment modality. (medscape.com)
Once infused, the cells continue to expand in number and bind to cancer cells via the engineered receptor, resulting in immunologic cancer cell death. (medscape.com)
Durable Responses and Low Toxicity After Fast Off-Rate CD19 Chimeric Antigen Receptor-T Therapy in Adults With Relapsed or Refractory B-Cell Acute Lymphoblastic Leukemia. (ucl.ac.uk)
Chimeric antigen receptor T cells for gamma-delta T cell malignancies. (ucl.ac.uk)
These include personalized anti-cancer vaccines (dendritic cell based) and chimeric antigen receptor (CAR)-T cell therapies for gastrointestinal and hepatobiliary cancers. (mayo.edu)
Several types of ACT round out the immunotherapy arsenal, including chimeric antigen receptor (CAR) T-cell therapy, T-cell receptor (TCR) therapy, and tumor-infiltrating lymphocyte (TIL) therapy. (aacr.org)
Infiltration, accumulation, and survival of chimeric antigen receptor T (CAR-T) cells in solid tumors is crucial for tumor clearance. (nature.com)
In this section, we will focus on NK cell immunotherapy, including the enhancement of antibody‐dependent cellular cytotoxicity, the manipulation of receptor‐mediated activation, inclusion criteria based on killer cell immunoglobulin‐like receptor (KIR) ligand mismatches, and adoptive immunotherapy with ex vivo expanded chimeric antigen receptor (CAR)‐engineered or engager‐modified NK cells. (intechopen.com)
Adoptive cellular therapy, especially chimeric antigen receptor (CAR) T cell therapy, has gained unprecedented success among hematologic tumors [ 11 ]. (hindawi.com)
However, systematic comparative studies of their effects on chimeric antigen receptor (CAR)-engineered T (CART) cells are lacking. (oncotarget.com)
The adoptive cellular immunotherapy with chimeric antigen receptor (CAR) immune cells, which involves modifying a patient's immune cells ex vivo with CARs that can recognize target antigens on tumour cells, is a promising approach. (academics.com)
One example is adoptive cell therapy with T cells that were genetically modified with gamma-retroviral and lentiviral (LV) delivery vectors to express a CD19-specific chimeric antigen receptor (CAR) for cancer treatment. (uni-wuerzburg.de)
This type of treatment is known as adoptive immunotherapy and the cells that are infused into the patients are known as universal chimeric antigen receptor T cells (UCAR T cells). (upenn.edu)
This is a Phase 1 study of central nervous system (CNS) locoregional adoptive therapy with autologous CD4 and CD8 T cells lentivirally transduced to express a HER2-specific chimeric antigen receptor (CAR) and EGFRt, delivered by an indwelling catheter in the tumor resection cavity or ventricular system in children and young adults with recurrent or refractory HER2-positive CNS tumors. (fredhutch.org)
The advent of chimeric antigen receptor (CAR) T cell therapy has revolutionized the treatment of relapsed/refractory acute lymphoblastic leukemia (r/r ALL). (confex.com)
This phase I trial studies the best dose and side effects of CD19/CD22 chimeric antigen receptor (CAR) T cells when given together with chemotherapy, and to see how well they work in treating children or young adults with CD19 positive B acute lymphoblastic leukemia that has come back or does not respond to treatment. (stanford.edu)
A CAR is a genetically-engineered receptor made so that immune cells (T cells) can attack cancer cells by recognizing and responding to the CD19/CD22 proteins. (stanford.edu)
Chimeric antigen receptor (CAR)-T cell therapies are on the verge of becoming powerful immunotherapeutic tools for combating hematological diseases confronted with pressing medical needs. (nature.com)
Adoptive T-cell therapy with anti-CD19 chimeric antigen receptor (CAR)-expressing T cells is a new approach for treating advanced B-cell malignancies. (ashpublications.org)
Advances in our understanding on the interaction between the immune system and tumor cells have contributed to the rapid development of novel therapeutic strategies based on chimeric antigen receptor (CAR) or T cell receptor (TCR) modified T cells. (ijbs.com)
In the last decade, Chimeric Antigen Receptor (CAR)-T cell therapy has emerged as a promising immunotherapeutic approach to fight cancers. (bvsalud.org)
This approach consists of genetically engineered immune cells expressing a surface receptor, called CAR, that specifically targets antigens expressed on the surface of tumor cells. (bvsalud.org)

Another approach relies upon the use of chimeric antigen receptors (CARs) that directly target cancer cells or immunosuppressive cellular elements in the tumor microenvironment. (upenn.edu)
Chimeric antigen receptors (CARs) are synthetic proteins expressed on the surface of T cells. (medscape.com)
Chimeric antigen receptors (CAR)-engineered T cells have demonstrated remarkable efficacy in patients with B-cell malignancies. (unimedizin-mainz.de)
In recent years, personalized cancer immunotherapy in the form of chimeric antigen receptors (CARs) in T cells (CAR T cells) has effectively treated some forms of leukemia and lymphoma. (thermofisher.com)
The urgent need for novel treatments inspired me to pursue a research project in adoptive immunotherapy, genetically modifying Tcells to express artificial T cell receptors, termed chimeric antigen receptors (CARs), that target AML specific antigens. (stanford.edu)
One way to achieve this is to genetically modify immune cells, mainly T cells and recently also natural killer (NK) cells, to express chimeric antigen receptors (CARs). (nature.com)
Adoptive T-cell therapy with T cells expressing chimeric antigen receptors (CARs) is an active area of cancer research. (ashpublications.org)
Primary T cells expressing chimeric receptors specific for tumor or viral antigens have considerable therapeutic potential. (nih.gov)
EBV-specific T cells expressing chimeric antitumor receptors may represent a new source of effector cells that would persist and function long-term after their transfer to cancer patients. (nih.gov)
Modification with chimeric antigen receptors (CARs) endows T cells with tumor specific cytotoxicity and thus induce anti-tumor immunity against malignancies. (ijbs.com)
NK cells contribute to cancer immune surveillance not only by their direct natural cytotoxicity which is triggered rapidly upon stimulation through germline-encoded cell surface receptors, but also by modulating T-cell mediated antitumor immune responses through maintaining the quality of dendritic cells and enhancing the presentation of tumor antigens. (frontiersin.org)
Furthermore, similar to T cells, specific recognition and elimination of cancer cells by NK cells can be markedly enhanced through expression of chimeric antigen receptors (CARs), which provides an opportunity to generate NK-cell therapeutics of defined specificity for cancer immunotherapy. (frontiersin.org)

More importantly, tumor antigens can be used in cancer therapy as tumor antigen vaccines. (wikipedia.org)
modelled the effects of immunotherapy, specifically dendritic cell vaccines and T cell adoptive therapy, on tumour growth with and without chemotherapy [ 13 ]. (hindawi.com)
He administered vaccines, his Coley Toxins, to hundreds of cancer patients. (genengnews.com)
This mechanistically rational antigen selection sequence, effective even for unvaccinated donors, regardless of HLA-haplotype, enables rapid identification of tumor protein regions relevant for cancer immunology, including adoptive immunotherapy, vaccines, and even identification of tumor neo-antigens unique to each patient. (ndltd.org)
Among tumor immunotherapies, neoantigen vaccines are in early human clinical trials and have demonstrated substantial efficiency. (wjgnet.com)

PRAME (preferentially expressed antigen in melanoma), a member of the cancer-testis antigen family, has been shown to have increased expression in solid tumors. (pipelinereview.com)
PRAME was first identified as a tumor-associated antigen through analysis of the specificity of tumor-reactive T-cell clones derived from a patient with metastatic cutaneous melanoma. (pipelinereview.com)
Subsequently, it has been shown that PRAME is expressed in many malignant neoplasms, including cutaneous melanoma, breast carcinoma, non-small cell lung cancer, and leukemia, whereas normal healthy tissues express minimal or no PRAME , with the exception of the testis and endometrium. (pipelinereview.com)
We successfully applied this strategy to the human TAAs p53, gp100 and MDM2-specific TCRs as promising antigens-driven immunotherapy for both melanoma and hematologic malignancies. (unimedizin-mainz.de)
Recombinant targeting modules will be based on antibodies and soluble single-chain fragments of TCR specific for melanoma antigens. (unimedizin-mainz.de)
Melanoma is a skin cancer with permanently increasing incidence and resistance to therapies in advanced stages. (mdpi.com)
Reports of spontaneous regression and tumour infiltration with T-lymphocytes makes melanoma candidate for immunotherapies. (mdpi.com)
Pembrolizumab (Keytruda), a humanized monoclonal anti-PD-1 antibody, is the first anti-PD-1 antibody approved by the FDA for the treatment of patients with unresectable or metastatic melanoma, non-small-cell lung cancer (NSCLC), head and neck squamous cell carcinoma, cervical cancer, colorectal cancer, and gastric/gastroesophageal junction cancer [ 4 - 10 ]. (hindawi.com)
Moreover, immunotherapy is highly effective for patients who have melanoma cancer when other radiation therapies and chemotherapy do not work. (medgadget.com)
Melanoma-associated antigen 3 (MAGE-A3) expression is generally restricted to the placenta and germline cells of the testis, but it may also be expressed in sarcoma and other cancers and is associated with poor prognosis. (moleculardepot.com)
In contrast to other cancers such as adenocarcinomas of the lung or melanoma, primary brain tumors like GB and low grade gliomas (LGG) are known as rather immunologically "cold" tumors, typically with low numbers of tumor-infiltrating lymphocytes (TILs) ( 4 ), and the mere amount of TILs is not associated with patient survival ( 5 ). (frontiersin.org)

Finding the right balance is a key consideration in cancer immunotherapy approaches such as combination therapies and precision medicine. (genengnews.com)
While many successful immunotherapeutic regimens have relied on checkpoint inhibition, other immunotherapeutic approaches, such as adoptive cellular therapies (ACT), the use of bispecific antibodies, and targeting components of the tumor microenvironment, are showing promise in a variety of cancer types. (aacr.org)
We now need to know how we can improve the current immunotherapy strategies so that not only a subset of patients respond, but even more patients can benefit from these therapies," Sharma said. (aacr.org)
Cancer immunotherapies can be divided into four major categories: - Cytokines/immunomodulation agents - Monoclonal antibodies - Cell‑based therapies - Oncolytic viruses Though monoclonal antibodies currently represent the largest class of commercialized cancer immunotherapies, cell‑based therapies are rapidly making headway. (technologynetworks.com)
This class of personalized therapies involves collecting immune cells from an individual, engineering them to recognize and kill cancer cells, before culturing, and reintroducing them into the same individual. (technologynetworks.com)
Based on the promising results achieved from antibody-mediated PD-1 blockade in the treatment of hematological and solid tumors, we are confident that PD-1 knockout CAR T cells enhance the potency of CAR T cell therapies for treatment of cancers without the side effects of antibody-based therapies. (uni-wuerzburg.de)
There are nearly 40 different therapies approved by the FDA for lung cancer. (mesotheliomaguide.com)
Due to the high rates of lung cancer among U.S. residents, the Food and Drug Administration (FDA) regularly reviews potential therapies for official approval. (mesotheliomaguide.com)
Lung cancer therapies include chemotherapy, immunotherapy and targeted therapy. (mesotheliomaguide.com)
With hormone therapies, if the first chemotherapy drug stops working and the cancer begins to grow again, a second or third drug can be used. (indiatimes.com)
However in the last years, immunotherapies using immune-checkpoint inhibitors (ICI), as well as cellular therapies, have moved into the limelight as promising alternative treatments. (nature.com)
Cancer stem cell populations within a growing tumor also help evade the inhibitory effects of chemo- as well as radiation-therapies, in addition to playing an important role in cancer metastases. (bvsalud.org)
The information is rapidly evolving and this review provides a comprehensive review of TF-ncRNAs interactions with implications on cancer stemness and in response to therapies. (bvsalud.org)
The number of approved cancer therapies is increasing rapidly. (msdmanuals.com)

The field of cancer immunology studies such topics. (wikipedia.org)
Building on interrogations in basic T cell biology in the lab, bench-to-bedside translational immunology is being developed, with a focus on T cell-based therapy for ovarian cancer. (upenn.edu)
Recent advances in cancer immunology, highlighted by immune checkpoint inhibitors, have demonstrated that immunotherapy is a viable option in the oncologist's armamentarium. (ndltd.org)

The only two diseases with more cases are prostate cancer and ovarian cancer. (mesotheliomaguide.com)
Peptide-mediated delivery of therapeutic mRNA in ovarian cancer. (moleculardepot.com)

Certain tumors have certain tumor antigens in abundance. (wikipedia.org)
Brain tumors are the most common solid tumor in pediatrics, accounting for 23.7% of new cancer diagnoses in children ( 1 1. (scielo.br)
As a part of the approach, the antigens were validated as being present in solid tumors through the use of the XPRESIDENT target discovery platform, according to the release. (pharmacytimes.com)
Tumor immunotherapy brings substantial and long-term clinical benefits that can even cure tumors. (hindawi.com)
Tumor immunotherapy refers to novel therapeutic measures that turn the immune system into a destructive force against tumors [ 1 ]. (hindawi.com)
However, targeting solid tumors is more challenging than targeting B-cell malignancies with CAR-T cells because of the histopathological structure features, specific antigens shortage and strong immunosuppressive environment of solid tumors. (ijbs.com)
Optimization of the design of CAR vectors, exploration of new targets, addition of safe switches and combination with other treatments bring new vitality to the CAR-T cell based immunotherapy against solid tumors. (ijbs.com)
In this review, we focus on the major obstacles limiting the application of CAR-T cell therapy toward solid tumors and summarize the measures to refine this new cancer therapeutic modality. (ijbs.com)
Nevertheless, targeting solid tumors is more challenging than targeting hematological malignancies because of tumor histopathological characteristics, shortage of specific antigens and local strong immunosuppressive microenvironment [ 4 ]. (ijbs.com)

NK expansion and activation were stimulated by culture with artificial antigen-presenting cells (aAPCs) and IL-2, in the presence or absence of BM-MSCs. (springer.com)
We and others previously created E562-centered artificial antigen-presenting cells (aAPCs) for the in vitro development of Capital t cells in both an antigen-specific and non-specific way (22, 24C28). (bioskinrevive.com)

Immunological and translational aspects of NK cell-based antitumor immunotherapies. (springer.com)
In contrast to T lymphocytes, donor NK cells do not attack any recipient tissues based on allogeneic human leukocyte antigens (HLAs), suggesting that NK‐mediated antitumor effects may be achieved without the risk of graft‐versus‐host disease (GvHD). (intechopen.com)
Recent advances in immuno-oncology (I-O) research are paving the way for the discovery of novel classes of cancer therapeutics that enhance or enable antitumor immune responses, overcome tumor evasion mechanisms, and promote conditions that favor immune protection. (thermofisher.com)
Adoptive cellular therapy transmits the sensitized T cells to patients with low cellular immune function, which helps patients obtain antitumor immunity. (hindawi.com)
One example is adoptive cell therapy with T cells that were genetically modified with gamma-retroviral and lentiviral (LV) delivery vectors to express a CD19-specific chimeric The advances in genetic engineering have enabled us to confer T cells new desired functions or delete their specific undesired endogenous properties for improving their antitumor function. (uni-wuerzburg.de)
Significantly, the chimeric antigen receptorCengineered antitumor Compact disc8+ Capital t cells extended via transient 475205-49-3 manufacture excitement shown excellent perseverance and antitumor reactions in adoptive immunotherapy mouse versions. (bioskinrevive.com)
Among these populations, TSCM cells have excellent perseverance and antitumor results in multiple malignancy immunotherapy versions (12C18). (bioskinrevive.com)

Tumor antigen is an antigenic substance produced in tumor cells, i.e., it triggers an immune response in the host. (wikipedia.org)
Tumor antigens are useful tumor markers in identifying tumor cells with diagnostic tests and are potential candidates for use in cancer therapy. (wikipedia.org)
Initially tumor antigens were broadly classified into two categories based on their pattern of expression: Tumor-Specific Antigens (TSA), which are present only on tumor cells and not on any other cell and Tumor-Associated Antigens (TAA), which are present on some tumor cells and also some normal cells. (wikipedia.org)
Tumor antigens, because of their relative abundance in tumor cells are useful in identifying specific tumor cells. (wikipedia.org)
Targeting immune checkpoint protein interactions is one form of cancer immunotherapy that offers a novel way to attack tumor cells. (thermofisher.com)
Cancer immunotherapy enables the immune system to target cancerous tumor cells. (medgadget.com)
Treatment for asbestos lung cancer aims to kill tumor cells, extending life expectancy, and alleviating symptoms and pain to improve your or a loved one's quality of life. (mesotheliomaguide.com)

Various mathematical models have been studied for cancer treatments with virotherapy, radiotherapy, chemotherapy, and immunotherapy [ 6 - 11 ]. (hindawi.com)
The model demonstrated that chemotherapy increases tumorigenicity, whereas CSC-targeted immunotherapy tumorigenicity. (hindawi.com)
Pratap proposed a model that describes the nonlinear dynamics between tumour cells, immune cells, and three forms of therapy: chemotherapy, immunotherapy, and radiotherapy [ 14 ]. (hindawi.com)
Chemotherapy and immunotherapy are the other two main types of lung cancer treatment. (mesotheliomaguide.com)
The first chemotherapy drug was approved for lung cancer in the 1940s. (mesotheliomaguide.com)
The primary benefit of chemotherapy is response time and works very well for metastatic breast cancer. (indiatimes.com)
In chemotherapy, the use of each type of drug for metastatic breast cancer is called a 'line' of treatment. (indiatimes.com)
Drugs used in chemotherapy, such as fludarabine phosphate and cyclophosphamide, work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. (stanford.edu)
For decades the only available cancer treatments were surgical resection as well as chemotherapy and/or radiotherapy [ 1 ]. (nature.com)
In hematological malignancies like leukemias, myeloma, and non-Hodgkin B-cell lymphomas, adoptive CAR-T cell therapy has shown efficacy in treating chemotherapy refractory patients. (bvsalud.org)

Immunotherapy is a promising approach for many oncological malignancies, including glioblastoma, however, there are currently no available tools or biomarkers to accurately assess whole-body immune responses in patients with glioblastoma treated with immunotherapy. (aacrjournals.org)
12 , 13 Clinical trials in which patients with advanced B-cell malignancies receive T cells expressing anti-CD19 CARs are in early stages, and it is not known whether adoptive transfer of T cells targeting this self-antigen will be an effective therapy for B-cell malignancies. (ashpublications.org)
The emerging therapeutic approach of CAR-T cell therapy has sparked great interests, extensive studies in preclinical and clinical trials have revealed encouraging therapeutic efficacy in treating a variety of cancers, particularly in treating B-cell hematologic malignancies with CD19 CAR-T cells [ 3 ]. (ijbs.com)

Cancer immunotherapy has demonstrated remarkable efficacy by checkpoint modulation in a large variety of neoplasms. (unimedizin-mainz.de)
Researchers must ensure reproducibility, efficacy and potency of cancer immunotherapy treatments before these reach the clinic. (technologynetworks.com)
While different methods exist to evaluate the efficacy of immunotherapy products, more efficient and robust in vitro assays are still required to ensure their safety and consistency. (technologynetworks.com)
The need for a novel cancer immunotherapy assay The most significant challenge faced by cancer immunotherapy researchers is the inability to predict treatment efficacy and response. (technologynetworks.com)
Despite reports of clinical efficacy, the application of NK cell immunotherapy is limited. (intechopen.com)
Collectively, these results may have a profound impact on the efficacy of CART cells in both hematologic and solid cancers. (oncotarget.com)

The use of ACI slows or stops the spread of cancer cells to other parts of the body and helps the immune system become more effective by eliminating cancer cells. (hindawi.com)
Dr. Kankeu Fonkoua's research efforts aim to harness the power of the immune system to develop safer and more-effective therapeutic strategies for patients with gastrointestinal and hepatobiliary cancers. (mayo.edu)
In recent years, however, cancer immunotherapy started getting a second look, partly because the immune system was better understood. (genengnews.com)
This treatment utilizes a patient's own immune system to recognize and attack cancer cells. (aacr.org)
The third plenary session of the AACR Annual Meeting 2019 , titled "Manipulating the Immune System in Cancer Therapy," focused on recent advances in the field of immunotherapy. (aacr.org)
Cancer immunotherapy consists of multiple approaches that harness and enhance the innate powers of the immune system to fight the disease. (technologynetworks.com)
In the rapidly growing field of immuno-oncology an individual's immune system is being employed as a new treatment modality to combat cancer. (thermofisher.com)
News and views, Immunotherapies, which refocus an individual's immune system to better fight disease, have shown promise in the treatment of cancer as well as other diseases. (thermofisher.com)
Intro Tumor immunotherapy, which intrusions the individuals personal immune system program to 475205-49-3 manufacture assault growth cells, is definitely a quickly growing treatment modality. (bioskinrevive.com)
Normally, potentially malignant cells are continuously eliminated by the immune system, but cancer cells can accumulate certain mutations, which allow them to escape these mechanisms [ 2 ]. (nature.com)
Cancer immunotherapies aim to support or boost the patient's immune system to enable the effective clearance of cancer cells. (nature.com)

New model systems are being developed to test and optimize various immunotherapy strategies, including bispecific antibodies, checkpoint inhibitors, epigenetic modifiers and adoptive T cell transfer both in vitro and in vivo. (upenn.edu)
The growth can be credited to the soaring investments in R&D as naked antigen-binding antibodies, bispecific antibodies, conjugated monoclonal antibodies, which have opened new avenues for revenue generation. (medgadget.com)

Immunotherapy based on the adoptive transfer of ex vivo expanded and activated autologous tumor-reactive lymphocytes can mediate tumor regression in cancer patients. (unimedizin-mainz.de)
The clinical trial is the first to use products consisting of autologous cytotoxic T lymphocytes that target tumor antigens using Immatics' target warehouse, according to a press release. (pharmacytimes.com)

These immunotherapy biomarkers would ultimately help risk stratify patients and optimize the timing and design of combinatorial approaches. (mayo.edu)
Immunotherapy approaches targeting MAGE-A3 in other cancers have shown mixed results in the clinic, however, use of cancer testis antigens such as MAGE-A3 may have therapeutic value in the treatment of soft tissue sarcomas. (moleculardepot.com)
Thus, it is imperative to develop more competent and safer immunotherapy approaches by optimizing the design of CAR vectors, exploring new targets, incorporating conditional safe switches and combining with other strategies. (ijbs.com)
We then outline preclinical approaches that employ CAR-NK cells for GB immunotherapy, and give an overview on the ongoing clinical development of ErbB2 (HER2)-specific CAR-NK cells currently applied in a phase I clinical trial in glioblastoma patients. (frontiersin.org)

Several types of adoptive cell transfer are under investigation, but CAR T-cell therapy is the first to enter clinical practice. (medscape.com)
Immatics recently announced patient enrollment into a phase 1 clinical trial of its adoptive cellular therapy (ACT) IMA101, which uses its ACTolog approach. (pharmacytimes.com)
Entering clinical development with our first adoptive cell therapy program is a significant step for Immatics, and highlights the ability of the XPRESIDENT platform to identify novel and true tumor antigens directly from a patient's tumor," said Harpreet Singh, PhD, chief scientific officer and CEO at Immatics US. (pharmacytimes.com)
We remain focused on driving our rich pipeline forward and generating clinical data that expands the evidence of our arenaviral platform technology to help address unmet needs in cancer. (financialcontent.com)
In June 2022, HOOKIPA announced positive Phase 1 monotherapy data for HB-200 for the treatment of advanced head and neck cancers at the American Society of Clinical Oncology (ASCO) Annual Meeting. (financialcontent.com)
My clinical training as a pediatric hematology oncology fellow at Memorial Sloan Kettering Cancer Center highlighted the desperate need for novel therapeutic options for a subtype of aggressive pediatric leukemia, Acute Myeloid Leukemia (AML). (stanford.edu)
Most CARs that are being evaluated in current clinical and preclinical studies recognize self-antigens that are expressed by normal tissues as well as malignant cells. (ashpublications.org)
CAR-T cell therapy has achieved outstanding progresses in clinical observations, which makes it even more attractive in the development of cancer adoptive immunotherapy. (ijbs.com)

The R&D activities are further resulting in the advent of mAbs, which have effects like antigen specificity, adaptive immunity, and antibody-dependent cellular toxicity. (medgadget.com)

Furthermore, our results show no human leukocyte antigen (HLA) expression loss and relatively high lymphocyte infiltration by lymphocyte specific protein tyrosine kinase (LCK) marker expression. (moleculardepot.com)
We hypothesized that many tumor associated antigens (Ag) are readily susceptible to immune attack, but only in the context of identifying the tumor antigen epitopes that can reliably initiate an immune response, regardless of individual patient human leukocyte antigen (HLA) haplotype restrictions. (ndltd.org)

The main challenge for the success of this approach is to obtain a great quantity of activated NK cells for adoptive transfer. (springer.com)
Here, we discuss effects of the GB tumor microenvironment on NK-cell functionality, summarize early treatment attempts with ex vivo activated NK cells, and describe relevant CAR target antigens validated with CAR-T cells. (frontiersin.org)

In approved products, a patient's own T lymphocytes are collected by apheresis and transduced with a gene that encodes for a CAR to direct the T cells against cancer cells. (medscape.com)
Metastatic cancer is difficult to control once it spreads and treatment depends on the original site of cancer based on how much it has spread, the patient's age and his/her medical history. (indiatimes.com)

Examples are alphafetoprotein (AFP) and carcinoembryonic antigen (CEA). (wikipedia.org)

Potential of arenaviral immunotherapies in novel combinations and against tumor self-antigens highlighted at AACR. (financialcontent.com)
In April 2022, HOOKIPA presented positive data at the 2022 American Association for Cancer Research Annual Meeting showing HOOKIPA's arenaviral immunotherapies induced potent T cell responses in novel combinations (such as co-stimulatory 4-1BB agonists or adoptive cell transfer) and against tumor self-antigens. (financialcontent.com)

Other examples include tissue differentiation antigens, mutant protein antigens, oncogenic viral antigens, cancer-testis antigens and vascular or stromal specific antigens. (wikipedia.org)
Some viral proteins are implicated in forming cancer (oncogenesis), and some viral antigens are also cancer antigens. (wikipedia.org)

However, high-avidity T cells specific for tumor-associated antigens (TAAs) are usually absent in patients because of self-tolerance. (unimedizin-mainz.de)
The addition of separate adapter molecules (AMs) specific for tumor antigens and CAR-immune cells targeting these AMs allows a more precise and temporally limited therapy. (nature.com)

Although numerous effective medical treatments against cancer have been developed, cancer treatment remains a challenging problem in neoteric medicine [ 3 ]. (hindawi.com)
investigated impulsive tumour growth models to describe medical interventions during cancer treatments [ 12 ]. (hindawi.com)
Many cancers still cannot be cured with standard treatments, so new therapeutic strategies are needed. (academics.com)
In addition, intracranial progression is common during systemic treatments due to the inability to penetrate central nervous system (CNS) barriers, whereas the intracranial effects of cancer immunotherapies remain unclear. (bvsalud.org)
Which Treatments Are Approved for Non-Small-Cell Lung Cancer? (mesotheliomaguide.com)
Treatments, including radiation & immunotherapy, have proven to be effective in patients with metastatic solid cancers. (indiatimes.com)

A key area of Dr. Kankeu Fonkoua's research endeavors is to identify mechanisms of resistance to immunotherapy. (mayo.edu)
The growing interest in non-coding RNAs (ncRNAs) in the recent years has provided further insight into the mechanisms by which TFs influence cancer stem cell characteristics. (bvsalud.org)

Cancer Immunotherapy Market Size to reach $101.6 billion at 14.8% CAGR by 2023. (medgadget.com)
The cancer immunotherapy market is anticipated to surpass a valuation of USD 101.6 billion, attaining a CAGR of 14.8% during the forecast period (2016-2023), Market Research Future (MRFR) unveils in a detailed report. (medgadget.com)

and (ii) tumour-infiltrating lymphocyte (TIL) therapy, in which cells are extracted from lymphocytes recovered from the patient with cancer and incubated with high concentrations of IL-2 before being injected back into the patient. (hindawi.com)
Feng and Navaratna demonstrated that the initial ratio between regulatory T cells and effector T cells impacts the tumour recurrence time and that the effectiveness of IL-2 use may reverse the immunotherapy outcome [ 15 ]. (hindawi.com)
The treatment for metastatic cancer is often different from the ones used for a normal tumour. (indiatimes.com)

This session was chaired by Padmanee Sharma, MD, PhD , professor in the Department of Genitourinary Medical Oncology at The University of Texas MD Anderson Cancer Center, who opened the plenary by highlighting the incredible breakthrough of checkpoint inhibitors, which are helping many patients to have durable responses. (aacr.org)
In recent years, tumor immunotherapy has achieved significant success in various cancers and has been one of the hotspots in the life sciences, especially immune checkpoint inhibitors and adoptive cellular therapy [ 3 ]. (hindawi.com)
Immune checkpoint inhibitors (ICIs) are antibodies that target crucial signaling pathways, such as programmed death 1 (PD-1)/programmed death-ligand 1 (PD-L1), and cytotoxic T-lymphocyte-associated protein 4 (CTLA-4), to improve the activation of T cells and enhance the immune response to cancer cells. (hindawi.com)
There are six immune checkpoint inhibitors approved for lung cancer. (mesotheliomaguide.com)

IMA101 is a personalized investigational immunotherapy being evaluated for the treatment of multiple cancers, including ovarian, gastric, esophageal, non-small cell lung cancers, and head and neck squamous cell carcinoma. (pharmacytimes.com)

Breakthroughs in anti-tumor immunity have led to unprecedented advances in immunotherapy, yet it is now clear that the tumor microenvironment (TME) restrains immunity. (elifesciences.org)
As T cell metabolism dictates effector function, it is now apparent that the effect of cancer cell metabolism on the tumor microenvironment (TME) may impair anti-tumor immunity, and these new hallmarks of cancer are therefore inextricably linked. (elifesciences.org)

Immunotherapy biomarkers. (mayo.edu)
Secondary objectives include, feasibility, persistence of T-cells in vivo , and assessment of anti-cancer activity, and biomarkers. (pharmacytimes.com)
Comprehensive solutions for cancer genomic biomarker discovery and verification across key immuno-oncology research areas Immuno-oncology research, aimed at discovering new cancer biomarkers that can become novel therapeutic targets, has experienced significant breakthroughs in cancer research. (thermofisher.com)

Here, the utility of OX40, a costimulatory molecule mainly expressed on activated effector T cells known to play an important role in eliminating cancer cells, was evaluated as a PET imaging biomarker to quantify and track response to immunotherapy. (aacrjournals.org)
This joint (Frankfurt/Mainz, Dresden, Essen, Heidelberg) translational immunotherapy project aims to combine NK cells as effector cells with universal epitope-specific CAR (UniCAR) with tunable activity. (unimedizin-mainz.de)
Accordingly, long-lived memory precursor effector T cells and antigen-specific T cells were increased by PD-1 blockade in intracranial lesions. (bvsalud.org)

These strategies rely on the isolation of T cells, which are either genetically modified to target tumor-specific antigens or are expanded from an endogenous population that recognizes tumor neoantigens. (aacr.org)

The Powell Lab is actively investigating and translating the application of immune-based therapy for cancer, with emphasis on gynecologic cancers. (upenn.edu)
The report includes a compilation of currently active projects in research and development of passive and active immunotherapy and adoptive cell therapy targeting PRAME. (pipelinereview.com)
Rosenberg is beginning to develop a library of TCRs that can recognize shared mutations in the hope of utilizing them for TCR T-cell therapy for patients across a variety of tumor types, especially those with common epithelial cancers. (aacr.org)
The ACTolog technique also creates multiple cell therapy products to target each antigen, which may be more effective than targeting a single antigen, Immatics reported. (pharmacytimes.com)
Comprehensive solutions to support CAR T-cell therapy research from T-cell engineering to sequencing Adoptive cell transfer is a rapidly emerging area of immuno-oncology research. (thermofisher.com)
Adoptive cell therapy (ACT) has emerged as an effective approach in immuno-oncology research. (thermofisher.com)
Alternating 2-vector therapy showed superior antigen-specific T cell responses, more robust anti-tumor activity and similar tolerability vs. single-vector therapy. (financialcontent.com)
In conclusion, we provide a novel platform for virus-free genetic engineering of CAR T cells that can be broadly applied in T-cell cancer therapy. (uni-wuerzburg.de)
A major mechanism for relapse after CD19-directed CAR T cell therapy is the recurrence of antigen-negative ALL cells. (confex.com)
Based on the recent success of anti-programmed death-1 (PD-1) therapy in undifferentiated pleomorphic sarcoma, we hypothesize that MAGE-A3-based immunotherapies may also provide benefits in this sarcoma type. (moleculardepot.com)
Among different restorative strategies, adoptive cell therapy is definitely one of the encouraging choices (1, 2). (bioskinrevive.com)
Besides modification based on a second-generation CAR, more advanced CAR-immune cell therapeutics are being tested, which utilize precise insertion of genes to circumvent graft-versus-host disease (GvHD) or employ a dual targeting approach and adapter CARs in order to avoid therapy resistance caused by antigen loss. (nature.com)
Thereby, several antigens can be targeted at once and the therapy can be adapted in case antigen-loss tumor variants appear. (nature.com)
To evaluate anti-CD19-CAR-transduced T cells in a murine model of adoptive T-cell therapy, we developed a CAR that specifically recognized murine CD19. (ashpublications.org)
NF-κB and STAT-3 are representative transcription factors (TFs) that have long been associated with cancer stemness, thus presenting as attractive targets for cancer therapy. (bvsalud.org)
Such knowledge will help uncover the many levels of tight regulations that control cancer stemness, providing novel opportunities and targets for therapy in the process. (bvsalud.org)
Overview of Cancer Therapy Curing cancer requires eliminating all cells capable of causing cancer recurrence in a person's lifetime. (msdmanuals.com)

Novel therapeutic strategies have been investigated, and immunotherapy has been recently approved for the treatment of various types of cancer [ 4 ]. (hindawi.com)

We made substantial progress in 2022 as we work to develop our novel arenaviral immunotherapies against a variety of cancers and infectious diseases. (financialcontent.com)

Therefore, many patients suffer from the adverse effects of the treatment in addition to therapeutic resistance and cancer recurrence. (hindawi.com)

In this paper, an antitumour model for characterising radiotherapy and immunotherapy processes at different fixed times is proposed. (hindawi.com)
Proton beam radiotherapy is an emerging treatment tool for cancer. (ndltd.org)

Immunotherapy includes the use of antigen- and nonantigen-specific substances, such as cytokines, as well as adoptive cellular immunotherapy (ACI) [ 3 ]. (hindawi.com)
Nevertheless, ex vivo activation with cytokines can restore cytolytic activity of NK cells against GB, indicating that NK cells have potential for adoptive immunotherapy of GB if potent cytotoxicity can be maintained in vivo . (frontiersin.org)

The ACTolog approach targets tumor-specific antigens to fight cancer. (pharmacytimes.com)
We believe that attacking multiple cancer targets simultaneously using our tailored approach may lead to promising new treatment options for cancer patients with significant unmet medical need. (pharmacytimes.com)
The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)

Two of the primary immunotherapies are immune checkpoint blockade (ICB) and adoptive cell transfer (ACT). (elifesciences.org)

Adoptive immunotherapy is a promising therapeutic approach for the treatment of chronic infections and cancer. (mdc-berlin.de)

It is a dose-limited factor of cancer immunotherapy and affects the prognosis and quality of life [ 15 ]. (hindawi.com)
Intracranial metastases are common in nonsmall-cell lung cancer (NSCLC) patients, whose prognosis is very poor. (bvsalud.org)

Anatomy24

Organisms8

Diseases33

Chemicals and Drugs109

Analytical, Diagnostic and Therapeutic Techniques and Equipment53

Phenomena and Processes31

Disciplines and Occupations1

Information Science4

Health Care13

Receptor23

Receptors12

Vaccines5

Melanoma11

Therapies14

Immunology3

Ovarian cancer2

Tumors9

Artificial antigen-prese2

Antitumor7

Tumor cells7

Chemotherapy10

Malignancies3

Efficacy6

Immune system11

Bispecific antibodies2

Autologous2

Approaches4

Clinical8

Specificity1

Human leukocy2

Activated NK cells2

Patient's2

Carcinoembryonic antigen1

Self-antigens2

Viral antigens2

Specific for tumor2

Treatments6

Mechanisms2

20232

Tumour3

Inhibitors4

Head and neck squamous cell carc1

Immunity2

Biomarkers3

Effector3

Genetically modified1

Therapy17

Novel therapeutic1

Variety of cancers1

Recurrence1

Radiotherapy2

Cytokines2

Targets3

Checkpoint blockade1

Therapeutic approach1

Prognosis2