• These findings indicate that nonfunctional dihydrofolate reductase in human leukemia cells share an antigenic determinant(s) with a functional form of the enzyme from L1210 murine leukemia cells. (aku.edu)
  • We have observed that DAC reduced the in vitro clonogenic potential in a dose-dependent manner of both human and murine leukemia and tumor cell lines. (biomedcentral.com)
  • Delta9-THC administered orally daily until death in doses of 50, 100, or 200 mg/kg did not increase the life-spans of (C57BL/6 times DBA/2)F1 (BDF1) mice hosting the L1210 murine leukemia. (erowid.org)
  • Peripheral blood mononuclear cells of healthy donors and post-transplant lymphoma patients were stimulated with or without lunasin in the presence of IL-12 or IL-2. (weeksmd.com)
  • The combination of lunasin and cytokines (IL-12 plus IL-2) was capable of restoring IFNγ production by NK cells from post-transplant lymphoma patients. (weeksmd.com)
  • Daphnezomine B ( 16 ), isolated from the leaves of the East Asian shrub Daphniphyllum humile , showed cytotoxicity toward murine lymphoma L1210 cells. (organic-chemistry.org)
  • Typical orthotopic disease models include breast cancer, lung cancer, colon cancer, kidney cancer and diffuse large B-cell lymphoma (DLBCL), utilising mice, rats and hamsters as test subjects. (medicilon.com)
  • We found that MMDX cytotoxicity for cultured M5076 tumor cells was potentiated 22-fold by preincubating the drug with NADPH-supplemented liver microsomes from untreated C57BL/6 female mice. (unboundmedicine.com)
  • Adding lunasin to IL-12- or IL-2-stimulated NK cells demonstrated synergistic effects in the induction of IFNG and GZMB involved in cytotoxicity. (weeksmd.com)
  • The rationale is based on a) evidence that, following drug-induced aplasia, resultant bone marrow proliferation in vivo corresponds temporally with induced humoral stimulatory activity, and on b) models that demonstrate increased cytotoxicity of β-cytosine arabinoside (Ara-C) to myeloblasts cultured in humoral stimulatory activity (HSA). (johnshopkins.edu)
  • Synthesis of Pyrazoloazepines from 5-Aminopyrazoles and Study of Their Cytotoxicity in Cancer Treatment. (sav.sk)
  • consequently, genes encoding some of these proteins are being used to design constructs for the inhibition of multiplying cancer cells. (weeksmd.com)
  • The reactivation of the TSGs ( p57KIP2 in HL-60 leukemic cells and p16CDKN2A in Calu-6 lung carcinoma cells) and the inhibition of global DNA methylation in HL-60 leukemic cells increased with DAC concentration. (biomedcentral.com)
  • The in vitro antineoplastic action of DAC correlated well with its inhibition of DNA methylation and reactivation of TSG in human neoplastic cells. (biomedcentral.com)
  • However, delta9-THC administered daily for 10 days significantly inhibited Friend leukemia virus-induced splenomegaly by 71% at 200 mg/kg as compared to 90.2% for actinomycin D. Experiments with bone marrow and isolated Lewis lung cells incubated in vitro with delta9-THC and delta8-THC showed a dose-dependent (10(-4)-10(-7)) inhibition (80-20%, respectively) of tritiated thymidine and 14C-uridine uptake into these cells. (erowid.org)
  • 5-3 with inhibition activity against leukemia cell line L1210 at concentration 1.515 ppm. (univpancasila.ac.id)
  • Inhibition of glutamine synthesis in cancer-associated fibroblasts was found to limit ovarian tumor growth [ 3 ] . (encyclopedia.pub)
  • Recent research has shown that GPNA can inhibit multiple other amino acid transporters and that GPNA's inhibition of cell viability is likely due to off-target effects from the activity of the γ-Glutamyltransferase enzyme rather than the disruption of glutamine metabolism [ 12 ] . (encyclopedia.pub)
  • In comparison with GPNA, V-9032 has approximately 100-fold increased potency in blocking cellular glutamine uptake, and inhibition of SLC1A5 with V-9032 was demonstrated to cause cell death, disrupt redox equilibrium, and result in disrupted development and progression of cancer [ 13 ] . (encyclopedia.pub)
  • In addition, dCK-deficient leukemia cell lines and ABT-888 (Veliparib) murine embryonic fibroblasts exhibited increased sensitivity to IR, indicating that pharmacologic inhibition of dCK may be an effective radiosensitization strategy. (biomasswars.com)
  • Furthermore, in tumour necrosis factor alpha (TNFa)-stimulated Ewing's sarcoma (ES) cells, NF-jB is reported to prevent activation of an apoptotic cascade through inhibition of c-Jun N-terminal kinase (JNK) [23] and upregulation of anti-oxidant enzymes [24]. (lsd1receptor.com)
  • In this study, we investigated the effects of Accepted 14 September 2009 nine naturally occurring compounds isolated from Citrus jambhiri Lush and Citrus pyriformis Hassk Available online 24 September 2009 (Rutaceae) for their potential to modulate the activity of P-gp in the multidrug-resistant human leukaemiacell line CEM/ADR5000. (gotomydoctor.com)
  • June Biedler (June 24, 1925 - April 16, 2012) was an American scientist primarily known for her discovery of proteins that lead to resistance of cancer cells to chemotherapy. (wikipedia.org)
  • Biedler began her career at Memorial Sloan Kettering Cancer Center (MSKCC) in 1947 when she joined the laboratory of Joseph A. Burchenal, M.D., a pioneer in the field of cancer chemotherapy. (wikipedia.org)
  • The in vivo antineoplastic activity of DAC administered as an i.v. infusion was evaluated in mice with murine L1210 leukemia by measurement of survival time, and in mice bearing murine EMT6 mammary tumor by excision of tumor after chemotherapy for an in vitro clonogenic assay. (biomedcentral.com)
  • Phase II trial of induction chemotherapy of pemetrexed plus split-dose cisplatin followed by pemetrexed maintenance for untreated non-squamous non-small-cell lung cancer. (shengsci.com)
  • abstract: PURPOSE:We conducted a phase II trial to evaluate the efficacy and safety of induction chemotherapy of pemetrexed plus split-dose cisplatin followed by pemetrexed maintenance for advanced non-squamous non-small-cell lung cancer (NSCLC). (shengsci.com)
  • Antimetabolites that are useful in cancer chemotherapy. (lookformedical.com)
  • In contrast, routinely administered chemotherapy drugs are commonly carcinogenic and can produce up to 26% of second cancers. (hydrazinesulfate.org)
  • which is one of the most accepted Received in revised form 2 September 2009 mechanisms for failure of chemotherapy in cancer treatment. (gotomydoctor.com)
  • In the United States, there are only two approved treatments for cancer, radiation and chemotherapy. (whydontyoutrythis.com)
  • Scientists have discovered that chemotherapy fuels cancer growth and kills the patient more quickly, yet nothing has been changed. (whydontyoutrythis.com)
  • They spoke to us about the possibility of Mykayla having a bone marrow transplant due to the leukemia not going into remission with the chemotherapy. (whydontyoutrythis.com)
  • 95% of children with leukemia go into remission during the first 30 days of chemotherapy… the majority of them go into remission just a few days after receiving chemotherapy for the first time. (whydontyoutrythis.com)
  • M5076 tumors in C57BL/6 mice and to prolong survival of DBA/2 mice with disseminated L1210 leukemia. (unboundmedicine.com)
  • However, pregnenolone-16alpha-carbonitrile pretreatment failed to enhance MMDX activity in mice bearing either s.c. (unboundmedicine.com)
  • In mice with L1210 leukemia and in mice bearing EMT6 tumors, the antineoplastic action of DAC also increased with the dose. (biomedcentral.com)
  • We also observed a correlation between in vitro and in vivo concentrations needed to produce optimal responses in mice with L1210 leukemia or with EMT6 tumor. (biomedcentral.com)
  • CD2F1 mice bearing L-1210 leukemia received a course of 60 mg Ara-C/kg every 8th hour (q.8 h) three times on day 0 and on another day in sequence (0.1 through 0.7). (johnshopkins.edu)
  • Although hydrazine sulfate is carcinogenic i.e., can cause cancer in some weanling mice given the drug in their drinking water since birth, there has never been a case of human cancer reported as a result of HS therapy . (hydrazinesulfate.org)
  • This is associated with increased tumourigenicity of ES cells in nude mice [25]. (lsd1receptor.com)
  • John J. Biesele, who became Biedler's thesis advisor, found unique chromosomal alterations in mouse leukemia L1210 sublines selected with various anticancer drugs. (wikipedia.org)
  • a complete loss of MMDX activity was observed in liver metastases-bearing animals receiving 40 microg/kg MMDX i.v. plus TAO. (unboundmedicine.com)
  • China accounted for 45.3% of new cases of primary liver cancer (PLC) worldwide in 2020. (bvsalud.org)
  • In particular, the group found that L1210 sublines that were resistant to the folate analogue aminopterin (later replaced by another folate analogue methotrexate) had increased levels of the dihydrofolate reductase enzyme (DHFR), a key component of DNA synthesis. (wikipedia.org)
  • Most cancer cells undergo metabolic reprogramming that support their survival and proliferation. (degruyter.com)
  • In order to restrict the proliferation of glutamine-addicted cancer cells, researchers have created various drugs that target different stages in glutamine metabolism. (encyclopedia.pub)
  • Increasing the DAC concentration and duration of exposure produced a greater loss of clonogenicity for both human leukemic and tumor cell lines. (biomedcentral.com)
  • Of note, an increased carbohydrate uptake and/or induction of death receptors of cancer cells was exploited to develop glycoconjugates that potentially induce cellular stress, ROS and apoptosis. (degruyter.com)
  • Cancer cells also enhance glucose-uptake to fuel these enhanced metabolic activities [ 2 ]. (degruyter.com)
  • Functional loss of the reduced folate carrier enhances the antitumor activities of novel antifolates with selective uptake by the proton-coupled folate transporter. (wayne.edu)
  • Quinocarcin ( 10 ), isolated from the culture broth of Streptomyces melanovinaceus , showed remarkable antiproliferative activity against lymphocytic leukemia, non-small cell lung cancer, and adenocarcinoma. (organic-chemistry.org)
  • METHODS:The antiproliferative activity and triggering of apoptosis of our sho. (shengsci.com)
  • The present study examined the role of CYP3A-mediated metabolism in the in vivo antitumor activity and host toxicity of MMDX in the mouse model and investigated the potential for increasing the therapeutic effectiveness of the drug by inducing its hepatic CYP-catalyzed activation. (unboundmedicine.com)
  • Understanding Lunasin 's biology and potential as a cancer therapeutic by utilizing Drosophila genetics. (weeksmd.com)
  • Immunostimulatory cytokines can enhance anti-tumor immunity and are part of the therapeutic armamentarium for cancer treatment. (weeksmd.com)
  • This indicates the intricate control of metabolism and redox balance for survival of cancer cells that can be targeted by therapeutic agents. (degruyter.com)
  • A review on therapeutic targeting of cancer via death receptors dissects this topic comprehensively and is therefore subtly discussed in this minireview which focuses on ROS cancer therapeutics [ 22 ]. (degruyter.com)
  • Glutaminolysis has emerged in recent years as an effective therapeutic focus in the treatment of cancer. (encyclopedia.pub)
  • Syngeneic mouse models test the ability of animals to fight cancer with an intact immune system and is used to test the therapeutic effects of immunotherapy. (medicilon.com)
  • This is why the plant has such a wide therapeutic potential for multiple diseases, including cancer. (whydontyoutrythis.com)
  • Fenretinide (N-(4-hydroxyphenyl)retinamide) is a synthetic vitamin A analogue with chemopreven-tive and therapeutic activity against a wide range of cancers [1]. (lsd1receptor.com)
  • "Sulforaphane and 2-oxohexyl isothiocyanate induce cell growth arrest and apoptosis in L-1210 leukemia and ME-18 melanoma cells" , Oncol Rep. 2003 Nov-Dec;10(6):2045-50. (sproutnet.com)
  • The exact mechanism of fen-retinide-induced cell death is not fully understood, although it is reported to induce apoptosis indepen-dently of retinoic acid receptor expression [6-9], lacking the carboxyl group required for binding to these receptors [10]. (lsd1receptor.com)
  • More recently, fenretinide-induced apoptosis has been reported to be dependent on phosphorylation of nuclear factor-kappa B (NF-jB) in SH-SY5Y neuroblastoma cells [13]. (lsd1receptor.com)
  • The NF-jB family of transcription factors are involved in the regulation of several physiological processes such as inflammation, cell cycle regulation and apoptosis. (lsd1receptor.com)
  • Consistent with this hypothesis, NF-jB is constitutively acti-vated in a wide variety of tumours permitting cells to evade apoptosis [16-19,21,22]. (lsd1receptor.com)
  • D) dCK kinase assay using L1210 nuclear and cytoplasmic fraction lysates, [3H]-dC as substrate and performed 2 hours after exposure to 3 Gy (*, P? (biomasswars.com)
  • 2009) A versatile non-radioactive assay for DNA methyltransferase activity and DNA binding. (jenabioscience.com)
  • the system is designed to identify and type hsv from direct lesion smears (ds) and from cell culture smears (cs) infected with a swab from the patient's lesion by means of an indirect fluorescence assay (ifa) using hsv type-common and hsv-2 type-specific monoclonal antibodies. (liverpool.ac.uk)
  • an enzyme linked immunosorbent assay (elisa) system to study specific anti-herpes simplex virus (hsv) antibody production in vitro by human peripheral blood mononuclear cells (pbmc) has been developed. (liverpool.ac.uk)
  • Cornelius Rhoads, the director of the institute, had assembled a group of medical researchers to find drugs that could inhibit growth of cancer cells. (wikipedia.org)
  • The development of anti cancer drugs that inhibit DNA synthesis in the 1950s and 1960s was a major clinical achievement. (wikipedia.org)
  • Using her skills in cytogenetics, Biedler, along with Dr. Dorris Hutchison, found that as resistance to methotrexate developed, unique patterns of chromosomal abnormalities were observed In 1976 Biedler and Barbara Spengler discovered the presence of an unusual banding pattern in chromosome 2 of cells that had been made resistant to methotrexate or other anti-folate drugs. (wikipedia.org)
  • Court cases in Oklahoma, Massachusetts, New Jersey, and California challenged the FDA's role in determining which drugs should be available to cancer patients. (cancer.gov)
  • abstract: PURPOSE:M30 and M65 ELISAs are proposed as surrogate biomarkers of tumour cell death in patients and are being applied increasingly in the pharmacodynamic (PD) evaluation of anticancer drugs during clinical trials. (shengsci.com)
  • It interferes with nucleic acid synthesis by inhibiting purine metabolism and is used, usually in combination with other drugs, in the treatment of or in remission maintenance programs for leukemia. (lookformedical.com)
  • In vivo antitumor activity experiments revealed that TAO completely suppressed the ability of 90 microg/kg MMDX i.v., a dose close to the LD10, to delay growth of s.c. (unboundmedicine.com)
  • Taken together, these findings demonstrate that an active metabolite(s) of MMDX synthesized via CYP3A contributes significantly to its in vivo antitumor activity and host toxicity. (unboundmedicine.com)
  • NK activation was evaluated, and its tumoricidal activity was assessed using in vitro and in vivo tumor models. (weeksmd.com)
  • In addition, NK cells stimulated with lunasin plus cytokines displayed higher tumoricidal activity than those stimulated with cytokines alone using in vitro and in vivo tumor models. (weeksmd.com)
  • in vitro and in vivo antiviral activity of 2'-fluorinated arabinosides of 5-(2-haloalkyl)uracil. (liverpool.ac.uk)
  • 5-(2-fluoroethyl)-2'-deoxyuridine (fedu), its 2'-fluoroarabinofuranosyl analog (fefau) and the 2'-fluoroarabinofuranosyl analog (cefau) of the potent anti-herpesvirus compound 5-(2-chloroethyl)-2'-deoxyuridine (cedu) were evaluated for activity against herpes simplex virus type 1 (hsv-1) and hsv-2 in vitro and in vivo. (liverpool.ac.uk)
  • The longest survival (250% of controls) was in animals whose second course began on day 3, the time of peak HSA as measured by DNA synthesis induced in L-1210 cells in culture. (johnshopkins.edu)
  • NF-jB knockdown did not induce death under normal growth conditions, but did reduce TNFa-dependent cell survival. (lsd1receptor.com)
  • Antiserum raised in chickens to dihydrofolate reductase purified from L1210 leukemia cells by affinity chromatography inhibited the catalytic activity and the binding of methotrexate by the enzyme. (aku.edu)
  • Lysates of human chronic myelogenous leukemia cells, which had neither catalytic activity for dihydrofolate reductase nor binding of methotrexate, blocked the inhibiting effect of the antiserum on the function of the enzyme in L1210 cell lysates. (aku.edu)
  • Selected flavonoids were tested for their ability to inhibit the catalytic activity of DNA topoisomerase (topo) I and II. (ucy.ac.cy)
  • Treatment with one drug would often result in development of resistance to unrelated agents Several different experimental approaches were used in attempts to determine whether development of resistance to the cytotoxic effects of cancer chemotherapeutic agents had a genetic basis. (wikipedia.org)
  • One such peptide, Lunasin , has been shown to selectively act on newly transformed cells while having no cytotoxic effect on non-tumorigenic or established cancer cell lines. (weeksmd.com)
  • We have shown that intensification of the DAC dose markedly increased its antineoplastic activity in mouse models of cancer. (biomedcentral.com)
  • This mini review highlights the development of compounds that target cancer cells by taking advantage of redox or metabolic alteration in cancer cells. (degruyter.com)
  • This review report displays the structures of new compounds isolated from algae-derived and sponge-derived fungi and their activities, covering the literature from 2017 to 2021. (japsonline.com)
  • Several compounds showed stronger activity than the control. (japsonline.com)
  • Modulation of histone deacetylase activity by dietary isothiocyanates and allyl sulfides: Studies with sulforaphane and garlic organosulfur compounds. (sproutnet.com)
  • Treatment of drug-resistant Caco-2 cells with the most active C. jambhiri and C. pyriformis compounds increased their sensitivity to doxorubicin and completely reversed doxorubicin resistance, which agrees with a decreased P- gp activity. (gotomydoctor.com)
  • Laetrile has been used for cancer treatment both as a single agent and in combination with a metabolic therapy program that consists of a specialized diet, high-dose vitamin supplements, and pancreatic enzymes . (cancer.gov)
  • By lowering the activation energy needed by cells to start metabolic reactions, enzymes allow biological systems to undertake necessary processes at the temperatures that exist inside the cell. (findbinaryoption.com)
  • Laetrile has shown little anticancer activity in animal studies and no anticancer activity in human clinical trials. (cancer.gov)
  • Cancer Chemother Pharmacol 2013 Feb 15. (wayne.edu)
  • High abundance of glucose in the cytoplasm of a cancer cell also increases flux into other metabolic pathways such as hexosamine biosynthetic pathway (HBP) [ 7 ]. (degruyter.com)
  • Clonogenic assays were performed on leukemic and tumor cell lines to evaluate the in vitro antineoplastic activity of DAC. (biomedcentral.com)
  • In order to clarify the dose-schedule of DAC as a guide to clinical trials, we have evaluated the antineoplastic activity of DAC both in vitro and in animal models. (biomedcentral.com)
  • "Antineoplastic activity of cannabinoids" J Natl Cancer Inst . (erowid.org)
  • 2005) Enhancement of antineoplastic action of 5-aza-2'-deoxycytidine by zebularine on L1210 leukemia. (jenabioscience.com)
  • In another review in 2022, Gao and Zhang (2022) reported a total of 196 new metabolites isolated from algae-associated fungi covering from 2016 to 2021, including the chemical diversity and biological activities. (japsonline.com)
  • Bilirubin is a chemical that is produced when old red blood cells break down. (webmd.com)
  • Our observations provide a strong rationale to perform clinical trials using dose intensification of DAC to maximize the chemotherapeutic potential of this epigenetic agent in patients with cancer. (biomedcentral.com)
  • These observations may be useful in the design of optimized dose-schedules of DAC for future clinical trials aimed at evaluating its full chemotherapeutic potential in patients with cancer. (biomedcentral.com)
  • Tumor cell resistance to anthracyclines and epipodophyllotoxins can be due to reduced drug accumulation and/or alterations in the activity of topoisomerase II (TOPO II). (ucy.ac.cy)
  • LBN rats bearing acute myelocytic leukemia (AML) were treated with 100 mg Ara-C/kg q.8 h six times begining on day 0 and on other days in sequence (0.1 through 0.12). (johnshopkins.edu)
  • The drug is used in the therapy of acute leukemia. (lookformedical.com)
  • Brave Mykala had T-cell acute lymphoblastic leukaemia, it's a very rare and aggressive form of childhood leukaemia. (whydontyoutrythis.com)
  • Traditionally the perspective on reactive oxygen species (ROS) has centered on the role they play as carcinogenic or cancer-causing radicals. (degruyter.com)
  • Despite early studies showing favorable results in limiting tumor growth and producing synergistic effects with other cancer therapies, GPNA has been identified by growing evidence to have low selectivity as a transporter inhibitor [ 10 ] [ 11 ] . (encyclopedia.pub)
  • Chemistry of RNA and DNA base methylation The addition of the methyl-group to DNA and RNA bases (Fig.?2) is catalyzed by DNA- and RNA-methyltransferases that use DNMTs, which methylate canonical dC bases.26 In contrast, DNMT1 maintains the methylation status Actinomycin D biological activity during cell division. (thebiotechdictionary.com)
  • DNMT1 operates on hemi-methylated DNA during replication, where the template strand is already methylated, but the newly synthesized strand is usually lacking methylation.27 As such, Actinomycin D biological activity DNMT1 converts the methylation of dC into an inheritable adjustment that may be transferred during duplication.28,29 Open up in another window Body 2. (thebiotechdictionary.com)
  • SAM as nature's methyl iodide is usually hence reactive enough to methylate even poor nucleophilic centers such Actinomycin D biological activity as the exocyclic amino groups of A, which feature, as an sp2-hybridized N-atom only a very poor nucleophilic lone pair at the system. (thebiotechdictionary.com)
  • Functional research are needed to Ezetimibe biological activity confirm biological relevance of the obtained relationships. (thebiotechdictionary.com)
  • Phosphorylation of serine 74 (Ser74) was shown to be critical in regulating enzyme activity [18]C[20]. (biomasswars.com)
  • Consequently, ROS-modulation has emerged as an anticancer strategy with synthesis of various ROS-inducing or responsive agents that target cancer cells. (degruyter.com)
  • 2009) Synthesis of a Labeled RGD-Lipid, Its Incorporation into Liposomal Nanoparticles, and Their Trafficking in Cultured Endothelial Cells. (ubc.ca)
  • Synthesis of short retinoidal amides related to fenretinide: antioxidant activities and differentiation-inducing ability. (shengsci.com)
  • However, relevant research has ebbed due to the limitation of these agents, which is the easy acquisition of tumor resistance by de novo glutamine synthesis in cancer or stromal cells. (encyclopedia.pub)
  • In double immunodiffusion, these human leukemia cell lysates formed a single precipitin line against the antiserum. (aku.edu)
  • Perwaiz Iqbal, M & Rothenberg, SP 1981, ' A nonfunctional protein in human leukemia cells reacts with antiserum to dihydrofolate reductase from L1210 leukemia cells ', Life Sciences , vol. 29, no. 7, pp. 689-696. (aku.edu)
  • A pharmacologically guided phase I study of carboplatin in combination with methotrexate and vinblastine in advanced urothelial cancer. (shengsci.com)
  • Over-expression of multidrug resistance-proteins has been shown to cause cross-resistance to doxorubicin, Cancer is one of the most important diseases in the world, killing topotecan, mitoxantrone, methotrexate and many other chemother- about every fifth or sixth person in western countries. (gotomydoctor.com)
  • Because cancer cells' reliance on glutamine metabolism is generally greater than in normal tissues, and glutamine deprivation in cancer cell cultures frequently results in cell death, scientists have explored depleting glutamine as a cancer therapy strategy. (encyclopedia.pub)
  • Gene therapy has attracted attention for its potential to specifically and efficiently target cancer cells with minimal toxicity to normal cells. (weeksmd.com)
  • It is this condemnation of hydrazine sulfate I wish to address the scientific gobbledygook of so-called studies, side effects, carcinogenicity, toxicity, cautions, critiques and inferences woven together by our cancer agencies' most talented spin doctors into a web of outright misrepresentations, deception and scientific fraud. (hydrazinesulfate.org)
  • 1 referred to leukemia dosages (≥ 3 mg/kg/day) of TG for the treatment of SARS-COV-2 and reasoned that due to the short time period the level of toxicity would be minimal. (xiahepublishing.com)
  • PURPOSE: Lung cancer incidences tend to be higher among males than females in both China and the United States, yet secular incidence patterns are different due to distinct population and environmental exposures. (bvsalud.org)
  • We examined long-term and future trends of lung cancer incidence, as well as the associations of age, period, and cohort effects with gender disparities. (bvsalud.org)
  • Her sponsor John Biesele, another of Rhoads' recruits, was a pioneer in the fields of mammalian cell culture and cytogenetic analysis Biedler spent a postdoctoral year in the laboratory of Georges Barski at L'Institut Gustave-Roussy (Villejuif, France) studying cell-cell hybridization techniques. (wikipedia.org)
  • 2005). Investivgation of factors responsible for cell line cytoplasmic expression differences. (ubc.ca)
  • 3). (C) Western blot of nuclear (N) and cytoplasmic (C) fractions of L1210 cell line before and 2 hours after 3 Gy exposure. (biomasswars.com)
  • Carboplatin is an alternative for cisplatin in the treatment of urothelial cancers. (shengsci.com)
  • BACKGROUND: Both depression and breast cancer (BC) contribute to a substantial global burden of morbidity and mortality among women, and previous studies have observed a potential depression-BC link. (bvsalud.org)
  • The effects of WR-1065 (2-((aminopropyl)amino)ethanethiol) on cell cycle progression, topoisomerase (topo) IIα activity, and topo IIα phosphorylation in Chinese hamster ovary (CHO) cells have been investigated. (ucy.ac.cy)
  • In most cell types, NF-jB is sequestered in the cytoplasm by association with IjBa [20]. (lsd1receptor.com)
  • BAY 11-7082 decreased cell viability, which was accompanied by caspase-3 cleavage. (lsd1receptor.com)
  • It has been used for a range of diseases in the past, such as leukemia and inflammatory bowel disease, and can be repurposed for other diseases, such as SARS-COV-2. (xiahepublishing.com)
  • abstract: PURPOSE:By a scaffold shortening strategy, a small series of retinoidal amides fenretinide (4-HPR) analogs have been synthesized from α, β-ionones and tested for their antiproliferative and differentiating activities, and antioxidant effect. (shengsci.com)
  • BAY 11-7082-induced cell death through an NF-jB-independent mechanism and enhanced cell death when combined with fenretinide. (lsd1receptor.com)
  • In this study we have investigated the role of NF-jB in fenretinide-induced cell death and the importance of NF-jB in ESFT. (lsd1receptor.com)
  • At present, it offers a promising direction for the treatment of cancer patients. (weeksmd.com)
  • This cancer information summary provides an overview of the use of laetrile as a treatment for people with cancer. (cancer.gov)
  • Laetrile was first used as a cancer treatment in Russia in 1845, and in the United States in the 1920s. (cancer.gov)
  • Inappropriate advertisement of laetrile as a cancer treatment resulted in a U.S. Food and Drug Administration investigation that culminated in charges and conviction of one distributor. (cancer.gov)
  • Their inclusion should not be viewed as an endorsement of the content of the websites, or of any treatment or product, by the PDQ Integrative, Alternative, and Complementary Therapies Editorial Board or the National Cancer Institute . (cancer.gov)
  • It has been used similarly to MERCAPTOPURINE in the treatment of leukemia. (lookformedical.com)
  • My silence has been occasioned by the hope that our federal and prominent private-sector cancer agencies would endorse the use of hydrazine sulfate, in the wake of clinical trials demonstrating its effectiveness in the treatment of cancer. (hydrazinesulfate.org)
  • Thanks to a growing awareness with regards to cannabis, and its high rate of success with individuals choosing to use it as a cancer treatment, more people are starting to realize the healing power of this plant. (whydontyoutrythis.com)
  • When you are an adult with cancer, you have the choice to use the two recommended options or refuse treatment and select alternative methods. (whydontyoutrythis.com)
  • an ATP-binding ), coumarins () and terpenoids cassette (ABC) transporter (150-170 kDa), which pumps out lipo- have been reported as philic agents from cells that have entered them by free diffusion agents for overcoming multidrug resistance, and could be used aloneat very low concentrations or in combination to reverse multidrugresistance in vitro. (gotomydoctor.com)