CamptothecinTopoisomerase I InhibitorsDNA Topoisomerases, Type IAntineoplastic Agents, PhytogenicTopotecanTopoisomerase InhibitorsCamptothecaDNA DamageAntineoplastic AgentsMolecular StructureTopoisomerase II InhibitorsTeniposideEnzyme InhibitorsDrug Screening Assays, AntitumorOrganosilicon CompoundsStructure-Activity RelationshipTumor Cells, CulturedRubiaceaeApoptosisOrganic Chemistry PhenomenaAphidicolinCell Line, TumorKB CellsDNAEtoposideDNA Topoisomerases, Type IICell SurvivalDrug ResistanceDNA, SuperhelicalKineticsMolecular Sequence DataAmsacrineEllipticinesLeukemia L1210Magnetic Resonance SpectroscopyInhibitory Concentration 50Intercalating AgentsDNA ReplicationCell LineDose-Response Relationship, DrugDNA CleavageLeukemia P388DNA RepairCell CycleBase SequenceLactonesDrug Resistance, NeoplasmIridoid GlucosidesMutationChemistry, OrganicNaphthoquinonesChromatography, High Pressure LiquidPlasmidsProdrugsDiterpenesBinding SitesDNA, NeoplasmAlkaloidsStereoisomerismSecondary MetabolismNeoplasmsSubstrate SpecificityCricetinaeTumor Suppressor Protein p53HeLa CellsPoly(ADP-ribose) PolymerasesHL-60 CellsDrug SynergismAmino Acid SequenceEstersCell DivisionProtein BindingDNA-Binding ProteinsHematoporphyrin DerivativeDrug CarriersHT29 CellsModels, MolecularIndicators and ReagentsIridoidsS PhaseDrug StabilityAcrylamidesCells, CulturedIndenesDNA FragmentationMass SpectrometryNucleic Acid Synthesis InhibitorsLeishmania donovaniColonic NeoplasmsFlavanonesMice, NudeDrug Evaluation, PreclinicalTime FactorsSaccharomyces cerevisiaeCatalysisDoxorubicinAffinity LabelsCaspasesCathaCricetulus