• Using a day 1 and 8, every-3-week schedule, our purpose was to determine the maximum tolerated dose of irinotecan (CPT-11, Camptosar) that can be administered immediately after gemcitabine (Gemzar) at a dose of 1,000 mg/m² IV. (cancernetwork.com)
  • Gemcitabine (Gemzar) and irinotecan (CPT-11, Camptosar) are active cytotoxic drugs against pancreatic cancer. (cancernetwork.com)
  • Docetaxel (Taxotere), gemcitabine (Gemzar), and irinotecan (Camptosar, CPT-11) are active single agents in a variety of solid tumors. (cancernetwork.com)
  • Synergy with no overlapping toxicities has been demonstrated for the combination of irinotecan ( Camptosar, CPT-11) and gemcitabine (Gemzar) in vitro. (cancernetwork.com)
  • Early clinical studies combining irinotecan (CPT-11, Camptosar) and gemcitabine (Gemzar) have yielded encouraging results. (cancernetwork.com)
  • For example, our investigators learned through a clinical trial that irinotecan (Camptosar ® ) and temozolomide (Temodar ® ) - drugs already used to treat colorectal cancer and brain cancer in adults - are effective against Ewing sarcoma that come backs after standard treatment. (mskcc.org)
  • BACKGROUND: Irinotecan (CPT-11, Camptosar@) is a first-line drug for metastatic colorectal cancer. (bvsalud.org)
  • Results of phase I and II clinical trials have demonstrated that single-agentirinotecan (7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin[CPT-11, Camptosar]), a camptothecin analog, has activity in pancreatic cancer.In previously untreated patients with advanced pancreatic cancer, Sakata et alreported an 11% partial response rate (4 out of 35 patients) using irinotecan at100 mg/m²/wk or 150 mg/m² every other week. (cancernetwork.com)
  • Camptosar (irinotecan) inhibits Topoisomerase-I activity, resulting in inhibition of DNA replication, and potentially leading to cell death and is indicated as a component of first-line therapy in combination with 5-fluorouracil and leucovorin for patients with metastatic or recurrent colorectal carcinoma (FDA.gov). (jax.org)
  • Irinotecan, sold under the brand name Camptosar among others, is a medication used to treat colon cancer, and small cell lung cancer. (wikipedia.org)
  • CAMPTOSAR Injection (irinotecan hydrochloride injection) is an antineoplastic agent of the topoisomerase inhibitor class.CAMPTOSAR is supplied as sterile, pale yellow, clear, aqueous solution. (drugcentral.org)
  • 5-Fluorouracil (5-FU) · Capecitabine (Xeloda) · Irinotecan hydrochloride (Camptosar) · Folinic. (donslon.ru)
  • The purpose of this study is to find out how effective the new combination of the drugs Capecitabine (Xeloda), Oxaliplatin (Eloxatin), and Irinotecan (Camptosar) are against colon and rectal cancer. (drugpatentwatch.com)
  • Patients with wild type K-RAS in tumors will be randomized to EZN-2208 + cetuximab or to standard of care (Camptosar® + cetuximab), patients must have failed regimens containing irinotecan (Camptosar®, CPT-11), oxaliplatin (Eloxatin®), and fluoropyrimidine. (stanford.edu)
  • Both irinotecan (CPT-11, Camptosar) and paclitaxel have beenshown to have single-agent activity in adenocarcinomas of the esophagusand gastric cardia. (cancernetwork.com)
  • On July 7, the FDA approved revisions to the safety labeling for irinotecan HCl injection (Camptosar, made by Pfizer, Inc.) to recommend reduced dosing in patients who are homozygous for the UDP-glucuronosyltransferase 1A1 (UGT1A1)-*28 allele. (medscape.com)
  • SN38 is around 1000 times more potent than Camptosar, according to Pfizer. (outsourcing-pharma.com)
  • Sorafenib should be used with caution when taken concomitantly with drugs eliminated primarily by the UGT1A1 pathway, such as irinotecan (Camptosar, Pfizer). (drugtopics.com)
  • CAMPTOSAR is intended for dilution with 5% Dextrose Injection, USP (D5W), or 0.9% Sodium Chloride Injection, USP, prior to intravenous infusion. (drugcentral.org)
  • He decided to go ahead and start the chemo, so about six weeks ago he started camptosar (90min x once a week, 4 weeks on, two weeks off for 6 months). (cancer.org)
  • How do genetic polymorphisms to UGT1A1*28 increase the risk for neutropenia when receiving irinotecan (Camptosar)? (ebmconsult.com)
  • To evaluate a patient with colorectal adenocarcinoma for therapy with irinotecan (Camptosar) therapy based on UGT1A1 enzyme activity. (medicalalgorithms.com)
  • It is well known that the chemotherapeutic regimen of irinotecan (CPT-11, Camptosar) in combination with 5-fluorouracil and leucovorin is an effective treatment for one of the most common forms of cancer in the western world, metastatic colorectal carcinoma. (ebmconsult.com)
  • Camptosar (irinotecan) inhibits Topoisomerase-I activity, resulting in inhibition of DNA replication, and potentially leading to cell death and is indicated as a component of first-line therapy in combination with 5-fluorouracil and leucovorin for patients with metastatic or recurrent colorectal carcinoma (FDA.gov). (jax.org)
  • Colorectal cancer combination regimen 1: CAMPTOSAR 125 mg/m2 intravenous infusion over 90 minutes on days 1, 8,15, 22 with LV 20 mg/m2 intravenous bolus infusion on days 1, 8, 15, 22 followed by 5-FU intravenous bolus infusion on days 1, 8, 15, 22 every weeks. (drugcentral.org)
  • 2.1)Colorectal cancer single agent regimen 1: CAMPTOSAR 125 mg/m2 intravenous infusion over 90 minutes on days 1, 8, 15, 22 then 2-week rest. (drugcentral.org)
  • 2.2)Colorectal cancer single agent regimen 2: CAMPTOSAR 350 mg/m2 intravenous infusion over 90 minutes on day every weeks. (drugcentral.org)
  • The currently recommended regimens are shown in Table 1.A reduction in the starting dose by one dose level of CAMPTOSAR may be considered for patients with any of the following conditions: prior pelvic/abdominal radiotherapy, performance status of 2, or increased bilirubin levels. (drugcentral.org)
  • Typically examples include the anticancer agent CPT-11 (irinotecan, Camptosar) that is a prodrug of SN-38, a potent topoisomerase I poison, and the antiviral drug oseltamivir phosphate (Tamiflu) that requires hydrolysis to the carboxylate form to yield the active neuraminidase inhibitor. (nih.gov)
  • By treating patients with the active metabolite of Camptosar instead, Neopharm hoped the drug could improve on Pfizer's drug, in terms of safety and efficacy. (outsourcing-pharma.com)
  • Irinotecan, sold under the brand name Camptosar among others, is a medication used to treat colon cancer, and small cell lung cancer. (wikipedia.org)
  • Irinotecan is available generically and under the brand name Camptosar in 2, 5 and 15 mL vials of 20 mg/mL. (nih.gov)
  • He wants Steve to be admitted to the hospital, overnight, while taking Cisplatin & Camptosar - 1 day every 3 weeks. (lungevity.org)
  • SN38 is the active metabolite of Camptosar - it is formed when Pfizer's approved cancer drug, Camptosar (irinotecan) is broken down in the body. (outsourcing-pharma.com)