Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human CREB Binding Protein (CREBBP) in Tissue homogenates and other biological fluids. (hudsen.org)
Description: A sandwich ELISA for quantitative measurement of Rat CREB binding protein(CREBBP) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. (hudsen.org)
To test a possible downstream target of PKG, we examined changes in phospho-CRE-binding protein (phospho-CREB) immunofluorescence in the CA1 cell body area and obtained results similar to those of the electrophysiology experiments. (jneurosci.org)
These results suggest that NO contributes to L-LTP by stimulating guanylyl cyclase and cGMP-dependent protein kinase, which acts in parallel with PKA to increase phosphorylation of the transcription factor CREB. (jneurosci.org)
One example is the activating transcription factor/cyclicAMP response element-binding protein (ATF/CREB) family that is defined by the ability of its members to bind to the cyclicAMP response element (CRE) in target promoters. (biomedcentral.com)
Intriguing new studies indicate that p30 II is a multifunctional regulator that differentially modulates CREB and Tax-responsive element-mediated transcription through its interaction with CREB-binding protein (CBP)/p300 and specifically binds and represses tax/rex mRNA nuclear export. (biomedcentral.com)
Activates3
After a ligand binds to the GPCR, it activates a heterotrimeric G-protein, which is composed of three subunits: a guanine nucleotide binding α-subunit, and a βγ-heterodimer (98). (pancreapedia.org)
Tax orchestrates multiple interactions with cellular transcription factors and activates transcription from the viral promoter and modulates the transcription or activity of numerous cellular genes involved in cell growth and differentiation, cell cycle control, and DNA repair [ 5 , 6 ]. (biomedcentral.com)
It is a hormone which binds to and activates the vitamin D receptor in the nucleus of the cell, which then increases the expression of many genes. (wikidoc.org)
Genes6
The protein is phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. (wikipedia.org)
Output from the circadian clock is transduced through regulating transcription of downstream genes directly by the oscillator components. (go.jp)
Integrated analysis of differential gene expression, previously reported quantitative trait loci, and genome-wide association studies indicated that TRIB3 , SAA ( SAA1 , SAA3 , and M-SAA3.2 ), VEGFA, PTHLH , and RPL23A were the most promising candidate genes affecting milk protein and fat percentage. (biomedcentral.com)
We had shown earlier that transcription of the cell cycle genes cyclin D1 and cyclin A in chondrocytes is dependent on CREs. (biomedcentral.com)
Here we demonstrate that overexpression of ATF3 in primary mouse chondrocytes results in reduced transcription of both genes, as well as decreased activity of a CRE reporter plasmid. (biomedcentral.com)
In the cell, T3 binds to a nuclear receptor, resulting in transcription of specific thyroid hormone response genes. (pharmaceuticalintelligence.com)
Nucleotide1
This protein binds the cAMP response element, a DNA nucleotide sequence present in many viral and cellular promoters. (wikipedia.org)
Kinase3
Three-train L-LTP was also blocked by inhibitors of guanylyl cyclase or cGMP-dependent protein kinase (PKG). (jneurosci.org)
Die Interleukin-1-Rezeptor-assoziierten Kinase 4 (IRAK-4) ist ein zentrales Protein des sogenannten „Myeloid differentiation primary response 88"-Signalwegs (MyD88-Signalwegs) (Suzuki et al. (springermedizin.de)
Risk factors for depression initiate an infection-like inflammation in the brain that involves activation microglial Toll-like receptors and glycogen synthase kinase-3β (GSK3β). (mdpi.com)
Neuronal2
Brain-derived neurotrophic factor (BDNF) is a member of the NGF family of neurotrophic factors (also named neurotrophins) that are required for the differentiation and survival of specific neuronal subpopulations in both the central as well as the peripheral nervous system. (novusbio.com)
Although different neuronal cell populations are affected across diverse neurodegenerative disorders, hallmark protein modifications is a common feature that supports the differential disease diagnosis and provides a mechanistic basis to gauge disease progression (Bossy-Wetzel et al. (maxwellmagneticmeds.co.za)
Nuclear1
Über Zwischenschritte führt dies zu einer Induktion der Transkriptionsfaktoren „nuclear factor-kappa of B cells" (NF-κB) und „activator protein-1" (AP-1) und einer konsekutiven Expression pro-inflammatorischer Zytokine (Abb. (springermedizin.de)
Transcriptional3
One member of this family, Activating Tanscription Factor 3 (ATF3), is expressed during skeletogenesis and acts as a transcriptional repressor, but the function of this protein in chondrogenesis is unknown. (biomedcentral.com)
Our data suggest that transcriptional induction of the Atf3 gene in maturing chondrocytes results in down-regulation of cyclin D1 and cyclin A expression as well as activation of RUNX2-dependent transcription. (biomedcentral.com)
Thus, it appears that HTLV-1 has yet another multifunctional protein with transcriptional and post-transcriptional roles in regulating viral gene expression. (biomedcentral.com)
Cyclic1
This cyclic conformation allows cyclic nucleotides to bind to proteins to which other nucleotides cannot. (pancreapedia.org)
Gene5
Alternate splicing of this gene results in two transcript variants encoding different isoforms. (wikipedia.org)
The Sox9 gene is required for the differentiation of mesenchymal precursor cells to chondrocytes and, together with the related L-Sox5 and Sox6 proteins, controls chondrocyte-specific gene expression [ 4 , 5 ]. (biomedcentral.com)
HIV-1 Tat can be an essential protein in the computer virus life cycle, which is required for computer virus gene expression and replication. (tech-strategy.org)
Only recently has it become clear that viral encoded proteins, the so-called "accessory" gene products of this complex retrovirus, play an integral role in the pathogenic process. (biomedcentral.com)
A stable cellular marker for the analysis of mouse chimeras: the bacterial chloramphenicol acetyltransferase gene driven by the human elongation factor 1 alpha promoter. (aitzol.com)
Cellular3
Cells express a pool of thousands of different proteins that need to be tightly controlled for proper cellular structure, organization, and function. (hindawi.com)
In addition, the subcellular distribution of mitochondria can affect the cellular transcriptome and transcription rates. (hindawi.com)
For example, HS proteins (HSPs) play an important role in cellular responses under HS conditions. (biomedcentral.com)
Molecular2
The proteostasis network (PN) is an assembly of distinct dynamic molecular pathways that control the functionality of the proteome (proteome homeodynamics) during protein synthesis, folding, trafficking, and degradation. (hindawi.com)
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. (novusbio.com)
Inhibition1
These cells may be a key factor ultimately mediating the deviation of the antagonistic response between tumor inhibition and tumor promotion. (explorationpub.com)
Synthesis2
3 hr, and is reduced by inhibitors of PKA and of protein or RNA synthesis. (jneurosci.org)
Conversely, either NO or cGMP analogs paired with one-train tetanization produced late-phase potentiation, and the cGMP-induced potentiation was blocked by inhibitors of protein or RNA synthesis and an inhibitor of PKG, but not by an inhibitor of PKA. (jneurosci.org)
Encodes2
BDNF cDNA encodes a 247 amino acid residue precursor protein with a signal peptide and a proprotein that are cleaved to yield the 119 amino acid residue mature BDNF. (novusbio.com)
HTLV-1 pX ORF II encodes two proteins, p13 II and p30 II whose roles are beginning to be defined in the virus life cycle. (biomedcentral.com)
ELISA1
Measured by its binding ability in a functional ELISA. (novusbio.com)
Accumulation2
Ageing leads to a gradual dysfunction of the proteostasis network and thus to proteome instability due to accumulation of damaged and/or misfolded proteins [ 2 ]. (hindawi.com)
Western blotting indicated that CNGC6 stimulated the accumulation of HS proteins via NO. (biomedcentral.com)
Chaperones1
The mitochondria have their own chaperones and proteolytic enzymes that remove damaged or unfolded proteins [ 18 - 20 ]. (hindawi.com)
Physiological1
It is becoming increasingly clear that, particularly for chronic neurodegenerative disorders occurring late in life, a complex combination of risk factors can initiate disease development and modify proteins that have a physiological function into ones with pathological roles via a number of defined mechanisms (Moreno-Gonzalez and Soto, 2011). (maxwellmagneticmeds.co.za)
Differentiation1
These repressors could down-regulate CRE-dependent transcription and thus cause delay of cell cycle progression and/or promote cell cycle exit during terminal differentiation. (biomedcentral.com)
Residues1
Two aspartic acid residues in the active site of the cyclase (AC or GC) promotes the binding of ATP. (pancreapedia.org)
Activate1
Depending on which family the G protein is, it goes on to activate (G αs protein subunit) or inhibit (G αi protein subunit) the membrane-bound cyclase. (pancreapedia.org)
Receptor3
One mechanism is the binding of an extracellular ligand to a transmembrane G-protein-coupled receptor (GPCR). (pancreapedia.org)
The receptor protein has seven transmembrane α-helices connected by alternating cytosolic and extracellular loops. (pancreapedia.org)
An important factor in this regard is Transient Receptor Potential (TRP) channel modulation and resultant activation of "brite" phenotype. (bvsalud.org)
Cells4
Matters of (A) Compact disc3+, (B) Compact disc8+, and (C) PD-1+ (designed cell-death protein 1) stromal cells. (tech-strategy.org)
A) Matters of intratumoral PD-1+ (designed cell-death protein 1) cells have HDAC5 been around in tendencies higher in major tumor. (tech-strategy.org)
Env into dendritic cells by anti-Tat antibodies, which were cross-clade binding and neutralizing. (tech-strategy.org)
Iodide is transported across the basement membrane of the thyroid cells by an intrinsic membrane protein called the Na/I symporter (NIS). (pharmaceuticalintelligence.com)
Viral1
Previous studies indicate the importance of these viral proteins in the ability of the virus to maintain viral loads and persist in an animal model of HTLV-1 infection. (biomedcentral.com)
Cell1
These processes are regulated by a large number of endocrine, paracrine and autocrine hormones and growth factors that, to a large part, act on chondrocyte cell surface receptors. (biomedcentral.com)
Family1
The neurotrophin family is comprised of at least four proteins including NGF, BDNF, NT-3, and NT-4/5. (novusbio.com)
Genetic3
Arguably the two most prominent factors are genetic variability and immunologic status of the exposed individual. (hindawi.com)
Furthermore, accumulating data indicate that alterations of immune responsiveness are partly dependent on genetic factors [ 4 ]. (hindawi.com)
Genetic polymorphisms, increasing age and environmental cues are recognized to be primary risk factors. (maxwellmagneticmeds.co.za)
Response element1
Transcription factors binding to the cyclicAMP response element (CRE) are known to regulate these processes. (biomedcentral.com)
Domain2
The ligand-binding site is in the extracellular domain and the cytosolic domain has a heterotrimeric G protein-binding site (127). (pancreapedia.org)
In the cytosol, the signal molecule binds to the heme-binding domain of the soluble cyclase. (pancreapedia.org)
Important1
Arguably, the most important "other" factor is adaptive and innate immunity of the exposed individual. (hindawi.com)
Disease3
The latter conclusion infers that susceptibility to infectious disease can be modified by host-related factors. (hindawi.com)
Inherent in this technically accurate paradox is that while the former supports the well-established link between microbial pathogens and infectious diseases, the latter infers that disease susceptibility can be modified by extramicrobial factors [ 1 - 3 ]. (hindawi.com)
Amyloid-beta plaques and tau protein tangles - hallmarks of the pathology - are most likely a non-specific result of the disease process, rather than a cause (Lee et al. (maxwellmagneticmeds.co.za)
Numerous1
In addition to these key regulators of chondrocyte maturation, numerous other transcription factors have been implicated in this process. (biomedcentral.com)
Mouse1
100% sequence homology with Mouse, Rat, Canine, Equine and all other mammalian proteins examined. (novusbio.com)
Environmental1
Plant growth is governed by many environmental factors, including heat shock (HS), which always causes serious damage to plants. (biomedcentral.com)