• Calponin is a calcium binding protein. (wikipedia.org)
  • Phosphorylation of calponin by a protein kinase, which is dependent upon calcium binding to calmodulin, releases the calponin's inhibition of the smooth muscle ATPase. (wikipedia.org)
  • Calponin is an actin filament-associated regulatory protein that can inhibit the activity of myosin- ATPase and stabilize the dynamics of the actin cytoskeleton. (ijpsonline.com)
  • Both the calponin 2 messenger ribonucleic acid and protein level were increasingly expressed in the tumor tissues of esophageal squamous cell carcinoma patients compared with the adjacent non-tumor tissue and correlated negatively with the tumor grade. (ijpsonline.com)
  • Calponin is a calmodulin, F-actin and tropomyosin binding protein which is thought to be involved in the regulation of smooth muscle contraction. (enzolifesciences.com)
  • Calponin a 34 kDa polypeptide, is a cytoskeleton-associated actin-binding protein that also interacts tropomyosin and calmodulin. (biocare.net)
  • Leucine rich repeats and calponin homology containing protein 4 (Lrch4) is a gene that encodes a protein predicted to have a C-terminal transmembrane domain, a calponin homology domain, and 5-8 leucine rich repeats (LRRs). (nih.gov)
  • Here we identified a novel actin stress fiber-associated protein, LIM and calponin-homology domains 1 (LIMCH1), which regulates NM-II activity. (nih.gov)
  • The basaloid cells around pseudocysts show myoepithelial differentiation and express p63, S-100 protein (patchy), actin (variable), vimentin, calponin and cytokeratin . (webpathology.com)
  • Opening of tandem calponin homology domains regulates their affinity for F-actin. (egelmanlab.org)
  • Calponin is responsible for binding many actin binding proteins, phospholipids, and regulates the actin/myosin interaction. (wikipedia.org)
  • To explore the pathologic significance of calponin 2 in esophageal squamous cell carcinoma, the expression level of calponin 2 proteins in the tumor tissue of 190 esophageal squamous cell carcinoma patients was examined with immunohistochemistry while the expression level of calponin 2 messenger ribonucleic acid was analyzed by using the data from The Cancer Genome Atlas database. (ijpsonline.com)
  • Calponin is a group of actin filament-associated regulatory proteins. (ijpsonline.com)
  • Many actin-binding proteins contain calponin homology (CH) domains, but the manner in which these domains interact with F-actin has been controversial. (egelmanlab.org)
  • Formalin-fixed, paraffin-embedded human Uterus stained with Calponin Rabbit Recombinant Monoclonal Antibody (CNN1/1408R). (neobiotechnologies.com)
  • SDS-PAGE Analysis of Purified Calponin Rabbit Recombinant Monoclonal Antibody (CNN1/1408R). (neobiotechnologies.com)
  • Immunofluorescence Analysis of Human K562 cells labeling CD71 with Calponin Rabbit Recombinant Monoclonal Antibody (CNN1/1408R)followed by Goat anti-rabbit IgG-CF488 (Green). (neobiotechnologies.com)
  • Calponin antibody has been found to be useful as a marker for myoepithelial and basal lamina in differentiating microinvasive from in situ ductal carcinomas of the breast. (biocare.net)
  • Calponin antibody may also have applications in malignant myoepithelium and pleomorphic adenoma of salivary gland as well as a useful marker for fine needle aspirates of papillary breast lesions. (biocare.net)
  • The family includes three members, calponin 1, calponin 2, and calponin 3 which are encoded by CNN1, CNN2, and CNN3 gene respectively[ 10 , 11 ]. (ijpsonline.com)
  • EndMT did not affect global H3K9me3 levels but induced a site-specific reduction of repressive H3K9me3 marks at promoters of mesenchymal genes, such as Calponin (CNN1), and genes involved in TGF-β signaling, such as AKT Serine/Threonine Kinase 3 (AKT3) and sulfatase 1 (SULF1). (nih.gov)
  • Calmodulin, when activated by calcium may bind weakly to the CH domain and inhibit calponin binding with α-actin. (wikipedia.org)
  • To explore the possible pathological significance of calponin in ESCC, in this study, we first examined the expression of calponin isoforms in the tumor tissue of ESCC patients and further explored their association with the disease. (ijpsonline.com)
  • Vav3 contains a calponin homology (CH) domain, an acidic domain (AC), the Dbl homology (DH) and pleckstrin homology (PH) domains which are common to all Rho GEFs, an atypical cysteine-rich zinc finger (C1) domain, a proline rich domain, a Src homology-2 (SH2) domain, and two Src homology-3 (SH3) domains flanking the single SH2 region. (cytoskeleton.com)
  • These domains in order of appearance are Calponin Homology (CH), regulatory domain (RD), and Click-23, domain that contains the calponin repeats. (wikipedia.org)
  • At the CH domain calponin binds to α-actin and filamin and binds to actin within the RD domain. (wikipedia.org)
  • A calponin homology domain is predicted in yeasst Cdc24p. (embl.de)
  • Calponin is also thought to negatively affect the bone making process due to being expressed in high amounts in osteoblasts. (wikipedia.org)
  • Further, in esophageal cancer tumor tissue, calponin 2 gene was found to co-express with genes associated with tight junction and the expression level of calponin 2 was observed to correlate significantly with the number of infiltrating immune cells. (ijpsonline.com)
  • Expression of the 29kDa form, I-calponin, is primarily restricted to muscle of the urogenital tract, whereas the higher molecular weight variant has been demonstrated in vascular and visceral smooth muscle. (neobiotechnologies.com)
  • Here, the first crystal structure of human MICAL3, which contains the flavin-containing monooxygenase (FMO) and calponin-homology (CH) domains, is reported. (korea.ac.kr)
  • Calponin tonically inhibits the ATPase activity of myosin in smooth muscle. (wikipedia.org)
  • In Western blotting, this MAb reacts with only the 34kDa form of calponin in extracts of human aortic medial smooth muscle and is unreactive with fibroblast extracts of cultivated human foreskin. (neobiotechnologies.com)
  • Calponin expression is restricted to smooth muscle cells and has been shown to be a marker of the differentiated (contractile) phenotype of developing smooth muscle. (neobiotechnologies.com)
  • 1996. Structure-function relations of smooth muscle Calponin. (neobiotechnologies.com)
  • Patients with higher calponin 2 in the tumor tissue were found to have longer overall survival time. (ijpsonline.com)
  • Calponin 2 was shown to be an independent factor influencing the overall survival of the esophageal squamous cell carcinoma patients. (ijpsonline.com)
  • These results supported the idea that calponin 2 is involved in esophageal cancer and may function as a tumor inhibitor probably through modulating cancer cells tight junction and tumor immunity. (ijpsonline.com)
  • Methylation analysis based on MethSurv database revealed a methylation site in the body of calponin 2 gene, which was associated with a better prognosis. (ijpsonline.com)
  • Furthermore, the myoepithelial markers SMA (Smooth Muscle Actin), Calponin, p63 and SMMHC can be used to determine whether or not a cancer has invaded, since benign and early lesions have an intact myoepithelial layer surrounding breast glands. (stratech.co.uk)
  • These have included antibodies against S-100, 3, 4 smooth muscle actin (SMA), 1, 5- 7 calponin, 1, 7, 8 h-caldesmon, 1, 8 and smooth muscle myosin heavy chain (SMMHC). (bmj.com)
  • 1, 10 Furthermore, studies have documented that antibodies to SMMHC and calponin, both markers of terminal smooth muscle differentiation, are more specific for breast MEC than are other more commonly used antibodies, such as those that recognise SMA. (bmj.com)
  • Primary antibodies included epithelial membrane antigen (EMA monoclonal 1:100 DAKO), cytokeratin (CK monoclonal 1:100 DAKO), CD99 (monoclonal 1:50 DAKO, vimentin (monoclonal 1:50 DAKO), S100 (polyclonal 1:300 DAKO), HMB45 (monoclonal 1:50 DAKO), bcl2 (monoclonal 1:50 DAKO) and calponin (monoclonal 1:50 DAKO). (ijpmonline.org)
  • These domains in order of appearance are Calponin Homology (CH), regulatory domain (RD), and Click-23, domain that contains the calponin repeats. (wikipedia.org)
  • Calponin contains three repeats of a well conserved 26 amino acid domain. (embl.de)
  • Calponin tonically inhibits the ATPase activity of myosin in smooth muscle. (wikipedia.org)
  • Calponin is responsible for binding many actin binding proteins, phospholipids, and regulates the actin/myosin interaction. (wikipedia.org)
  • Inhibin and calponin were focally positive. (medscape.com)
  • Immunohistochemical analysis of these lesions reveals that they are classically positive, at least focally, for smooth muscle actin, calponin and muscle-specific actin. (johnshopkins.edu)
  • The interaction of calponin with actin inhibits the actomyosin MgATPase activity. (embl.de)
  • In Western blotting, this antibody reacts with only the 34kDa form of calponin in extracts of human aortic medial smooth muscle and is unreactive with fibroblast extracts of cultivated human foreskin. (teomics.com)
  • Calmodulin, when activated by calcium may bind weakly to the CH domain and inhibit calponin binding with α-actin. (wikipedia.org)
  • The tumor is diffusely and strongly positive for CK7 and Cam 5.2, weakly positive for GATA3, and negative for Calponin. (uab.edu)
  • At the CH domain calponin binds to α-actin and filamin and binds to actin within the RD domain. (wikipedia.org)
  • Here we present the crystal structure of the ILK KD bound to its cytoskeletal regulator, the C-terminal calponin homology domain of alpha-parvin. (rcsb.org)
  • 3. Immunohistochemical Expression of Calponin in Cutaneous Basal Cell Carcinoma. (nih.gov)
  • the E-value for the Calponin domain shown below is 1.1e-18. (embl.de)
  • Description: A sandwich ELISA kit for detection of Calponin 1, Basic from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (jemsec.com)