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  • PMID
  • Several infants with severe forms of long-QT syndrome (LQTS) who displayed life-threatening ventricular arrhythmias together with delayed neurodevelopment and epilepsy were found to have mutations in either this gene or another member of the calmodulin gene family (PMID:23388215). (nih.gov)
  • Mutations in this gene have also been identified in patients with less severe forms of LQTS (PMID:24917665), while mutations in another calmodulin gene family member have been associated with catecholaminergic polymorphic ventricular tachycardia (CPVT)(PMID:23040497), a rare disorder thought to be the cause of a significant fraction of sudden cardiac deaths in young individuals. (nih.gov)
  • complexes
  • Rief and Junker used mechanical force - actually pulling on complexes of calmodulin and the target peptides at rates of 1 nanometer per second or less - to slow down the processes to observable time scales and to clearly separate the individual unbinding steps. (innovations-report.com)
  • The binding of enzymes may be enhanced if the enzyme substrate is present and enzyme-substrate-calmodulin-Ca 2+ complexes are particularly stable. (sigmaaldrich.com)
  • inhibits
  • Chlorpromazine inhibits the action of calmodulin which is contained in the thyroid and may act on tubulin assembly-disassembly (3). (springer.com)
  • peptides
  • Activation of the enzyme is ligand-dependent-peptides with higher affinities for wild-type calmodulin exhibit increased switch activity. (harvard.edu)
  • Regulation
  • In this system, we investigate the hitherto unknown physiological roles of calmodulin (CaM) in light adaptation and in regulation of the inward current that is brought about by depletion of cellular Ca 2+ stores. (pnas.org)
  • Plasma
  • Calmodulin is expressed in many cell types and can have different subcellular locations, including the cytoplasm, within organelles, or associated with the plasma or organelle membranes. (acris-antibodies.com)
  • role
  • These findings led us to postulate that calmodulin plays a role in TSH-induced thyroid hormone secretion. (springer.com)
  • Calcium plays a role in regulating the expression and function of beta-adducin to sustain normal organization of the spectrin -based cytoskeleton and the differentiation properties in keratinocytes through the calmodulin / EGFR / cadherin signaling pathway. (antibodies-online.com)