• Huwentoxin-I is known to be an inhibitor of tetrodotoxin -sensitive voltage-gated sodium channels (TTX-S) (IC 50 ~ 50 nM) and N-type voltage-sensitive calcium channels (IC 50 ~ 100 nM) in mammalian DRG, hippocampus and insect's DUM neurons. (smartox-biotech.com)
  • It has only a very weak effect on L-type calcium channels, no effect on TTX-R channels and has virtually no effect on muscle sodium channels. (smartox-biotech.com)
  • The selectivity of Huwentoxin-I for calcium channels appears to be higher than ω-conotoxin MVIIA and equivalent to ω-conotoxin GVIA . (smartox-biotech.com)
  • Huwentoxin-I (HWTX-I) is a 33-residue peptide isolated from the venom of Ornithoctonus huwena and could inhibit TTX-sensitive voltage-gated sodium channels and N-type calcium channels in mammalian dorsal root ganglion (DRG) neurons. (smartox-biotech.com)
  • Chen J, Liu X, Yu S, Liu J, Chen R, Zhang Y, Jiang L, Dai Q (2021) A novel ω-conotoxin Bu8 inhibiting N-type voltage-gated calcium channels displays potent analgesic activity. (conoserver.org)
  • The voltage-dependent N-type calcium channel subunit alpha-1B is a protein that in humans is encoded by the CACNA1B gene. (wikipedia.org)
  • In this study, we sought to combine the pore blocking activity of conotoxins with the gating modifier activity of spider toxins to design new bivalent inhibitors of NaV1.7 with improved potency and selectivity. (bvsalud.org)
  • They are inhibited by the marine snail toxin, omega conotoxin MVIIC. (lookformedical.com)
  • A neurotoxic peptide, which is a cleavage product (VIa) of the omega-Conotoxin precursor protein contained in venom from the marine snail, CONUS geographus. (lookformedical.com)
  • During fast synaptic transmission the release of neurotransmitter from vesicles in presynaptic terminals is controlled by calcium ions (Ca 2+ ) ( Katz, 1969 ). (jneurosci.org)
  • A family of structurally related neurotoxic peptides from mollusk venom that inhibit voltage-activated entry of calcium into the presynaptic membrane. (nih.gov)
  • The magnitude of dendrodendritic transmission is directly proportional to dendritic calcium influx. (nih.gov)
  • A class of drugs that act by selective inhibition of calcium influx through cellular membranes. (lookformedical.com)
  • Voltage-dependent cell membrane glycoproteins selectively permeable to calcium ions. (lookformedical.com)
  • The voltage-dependent N-type calcium channel subunit alpha-1B is a protein that in humans is encoded by the CACNA1B gene. (wikipedia.org)
  • The alpha-1 subunit is the binding site for calcium-based antagonists. (lookformedical.com)
  • The α1B protein, together with β and α2δ subunits forms N-type calcium channel (Cav2.2 channel) PMID 26386135. (wikipedia.org)