OxidativeAlzheimer'sDysfunctionDisruption of calcium homeostasisMetabolicEndoplasmic reticulumNeurodegenerative diseasesNeuronsEnergy metabolismCellularIntracellular calciumAbnormallyModulatorPhosphateGeneIonsGlucoseImmuneProteinRestorationRenalAggregationSkeletalMolecularHypothesisProcessesContributeConcentrationRYR1CommonTransportCellsResultsLevelsPrimary
Oxidative9
- In addition, an increasing body of evidence suggests a potential link between oxidative energy metabolism dysregulation and chronic low-grade inflammation [ 4 , 9 ]. (hindawi.com)
- Mitochondrial dysfunction occurs at an early stage of axon degeneration and involves oxidative stress, energy deficiency, imbalance of mitochondrial dynamics, defects in mitochondrial transport, and mitophagy dysregulation. (nih.gov)
- Numerous factors, including amyloid-β (Aβ) aggregation, calcium homeostasis dysregulation, and oxidative stress, contribute to disease development and interplay with each other. (sc.edu)
- Biochemically, the tissue thio-barbituric acid reactive species (TBARS), super-oxide anion content (markers of oxidative stress) and total calcium levels were measured. (biomedcentral.com)
- Furthermore, vincristine administration was also associated with an increase in oxidative stress and calcium levels. (biomedcentral.com)
- However, administration of Ocimum sanctum (100 and 200 mg/kg p.o. ) and its saponin rich fraction (100 and 200 mg/kg p.o. ) for 14 days significantly attenuated vincristine-induced neuropathic pain along with decrease in oxidative stress and calcium levels. (biomedcentral.com)
- It may be concluded that Ocimum sanctum has ameliorative potential in attenuating chemotherapy induced-painful neuropathic state, which may be attributed to decrease in oxidative stress and calcium levels. (biomedcentral.com)
- The mitochondrial dysfunction will cause severe oxidative stress and disruption in calcium homeostasis. (magtechjournal.com)
- Neuroinflammation and oxidative stress, mitochondrial dysfunction, dysregulation of the expression of histone deacetylases, and aggregation of pathogenic forms of proteins are among the most common and significant pathological features of neurodegenerative diseases. (actanaturae.ru)
Alzheimer's1
- Calcium dysregulation ("Calcium Hypothesis") is an early and critical event in Alzheimer's and other neurodegenerative diseases. (biomedcentral.com)
Dysfunction3
- Our primary interest is the regulation of cardiac ion channels with emphasis on diseases arising from their dysfunction, especially calcium-dependent arrhythmias and structural cardiomyopathies. (wisc.edu)
- The recognition of genetic determinants connected to Parkinsons disease offers led to the proposition that irregular processing of aberrant or misfolded proteins, mitochondrial dysfunction, disruption of the autophagy-lysosome system, endoplasmic reticulum stress, dysregulation of calcium homeostasis may contribute to the deterioration of dopaminergic neurons [5, 6]. (e-core.org)
- We aim to understand how the dysregulation of protein synthesis could contribute to the synaptic dysfunction observed in AD. (iisc.ac.in)
Disruption of calcium homeostasis1
- Subsequent disruption of calcium homeostasis and myocardial remodeling leads to a progressive impairment of ventricular myocyte contractility that may result in heart failure [ 6 - 8 ]. (hindawi.com)
Metabolic2
- These kinds of metabolic dysregulation might be taken advantage of diagnostically, for the exact purpose to make certain correct decryption involving gene alternatives, specially those using unidentified importance, along with help first growth discovery via regular individual follow-up. (mirna1.com)
- Additionally ATD autoimmune thyroid disease , SDHx and also FH Sun modify cell phone pathways, which include Genetics hypermethylation, hypoxia signaling, redox homeostasis, Genetic make-up repair, calcium supplement signaling, kinase flows, and also key as well as metabolic rate. (mirna1.com)
Endoplasmic reticulum1
- Artemisinin, a thapsigargin-like sesquiterpene has been shown to inhibit the Plasmodium falciparum sarco/endoplasmic reticulum calcium-ATPase PfSERCA. (hal.science)
Neurodegenerative diseases1
- At least three common themes appear to underlie all well-studied neurodegenerative diseases: disruptive protein deposits, calcium dysregulation and neuroinflammation. (biomedcentral.com)
Neurons1
- Mitochondria are organelles responsible for bioenergetic metabolism, calcium homeostasis, and signal transmission essential for neurons due to their high energy consumption. (nih.gov)
Energy metabolism2
- To understand this, we study two major aspects - 1) the role of energy metabolism and 2) the role of calcium signaling, and how they are integrated to regulate synaptic/activity mediated protein synthesis. (iisc.ac.in)
- Exploring the link between energy metabolism and calcium homeostasis with synaptic protein synthesis is relevant in neurodegeneration as each of these aspects are individually shown to be affected. (iisc.ac.in)
Cellular4
- Other effects include impaired cellular respiration, altered cell signaling , apoptosis , and impaired calcium homeostasis . (bmglabtech.com)
- The metal ions imbalance induces Aβ and tau pathologies by directly or indirectly affecting multiple cellular/subcellular pathways, and the disrupted homeostasis can reversely aggravate the abnormalities of metal ions transportation/deposition. (wmcresearch.org)
- The extracellular concentration of Ca2+ is 103 M, which is almost ten-thousand times higher than that of the intracellular Ca2+ (107 M). As a common second messenger, cellular calcium homeostasis plays a pivotal role in regulating many neuronal functions, including neural growth and differentiation, action potential, synaptic plasticity, and learning and memory. (wmcresearch.org)
- 09 Intracellular signaling cascades are highly regulated to maintain cellular homeostasis. (facts.net)
Intracellular calcium2
- We apply state-of-the art imaging, electrophysiology and cell biology tools to understand how mutations affecting proteins involved in excitation-contraction coupling, such as ryanodine receptor 2, the major intracellular calcium channel in the heart, participate in the development of disease and, therefore, can be targets for drug development. (wisc.edu)
- The mechanism underlying SBVR is not completely understood but it is known that SBVR depends on stochastic ion channel gating, intracellular calcium handling and intercellular coupling. (unideb.hu)
Abnormally1
- As a result, abnormally large amounts of calcium ions are released from storage within muscle cells. (medlineplus.gov)
Modulator2
- Transmembrane activator and calcium modulator and cyclophilin ligand interactor (TACI) is a receptor for the TNF superfamily cytokines, B cell-activating factor (BAFF), and A proliferation-inducing ligand (APRIL). (nih.gov)
- The latter contains the calcium homeostasis modulator family member 6 gene CALHM6 (previously called FAM26F). (rug.nl)
Phosphate5
- Calcium and Phosphate Homeostasis is of major importance to a large number of hysiological processes thereby affecting several organ systems typically bone, muscles, kidney, brain with consequences on quality of life and risk of chronic disability. (endo-ern.eu)
- For calcium (Ca) and phosphate (Pi), 3 subthematic groups are identified based on the pathophysiology of the diseases, the multidicplinary care involved and long-term consequences as well as the different research approaches. (endo-ern.eu)
- Disorders of phosphate imbalance share abnormal bone and teeth structure, as well as a dysregulation of the FGF23 endocrine system. (endo-ern.eu)
- Calcium (Ca), phosphate (P), and parathyroid hormone (PTH) are important variables influencing the risk for cardiovascular disease in dialysis patients. (eur.nl)
- Efforts to improve calcium-phosphate-PTH homeostasis in patients on the waiting list for renal transplantation should be encouraged also to improve graft survival. (eur.nl)
Gene2
- Transcriptional dysregulation is considered a key molecular mechanism responsible of HD pathogenesis but, although numerous studies investigated mRNA alterations in HD, so far none evaluated a whole gene expression profile in blood of R6/2 mouse model. (biomedcentral.com)
- Among the factors leading to pathological processes, microbes, viruses, gene dysregulation and immune system disorders have been described. (mdpi.com)
Ions6
- The proteins produced from the RYR1 and CACNA1S genes are involved in the movement of calcium ions within muscle cells. (medlineplus.gov)
- When the RYR1 channel is active, it releases calcium ions from storage into the fluid-filled space inside muscle cells. (medlineplus.gov)
- An overabundance of calcium ions also causes skeletal muscles to contract, which leads to muscle rigidity. (medlineplus.gov)
- The homeostasis of metal ions, such as iron, copper, zinc and calcium, in the brain is crucial for maintaining normal physiological functions. (wmcresearch.org)
- Calcium is one of the highest metal ions (~ 1200 g) in adult human body. (wmcresearch.org)
- 07 Second messengers, such as cyclic AMP and calcium ions, play a crucial role in signaling cascades. (facts.net)
Glucose2
- Here, we demonstrate that TACI-deficient mice subjected to high-fat diet (HFD) are protected from weight gain and dysregulated glucose homeostasis. (nih.gov)
- Thus, the adoptive transfer experiments offer a model where TACI-deficient Mϕs accumulate in VAT and protect against metaflammation and obesity-associated dysregulation of glucose metabolism. (nih.gov)
Immune2
- These include inflammasome activation and secretion of pro-inflammatory cytokines, modified calcium homeostasis, changes in the blood-brain barrier permeability, recruitment of peripheral immune cells or production of autoantibodies. (e-core.org)
- Our results suggest that a genetically conferred risk of immune dysregulation may be a key component in the pathogenesis of SSNS. (rug.nl)
Protein3
- Calcium binds to and regulates the small regulatory protein calmodulin that in turn binds to and regulates several hundred calmodulin binding proteins. (biomedcentral.com)
- The small calcium-binding protein calmodulin (CaM) is a primary effector of calcium function and works in turn by binding to and regulating CaM-binding proteins (CaMBPs) [ 53 ]. (biomedcentral.com)
- The current review will explore a hypothesis of the involvement of the calcium-regulating hormones such as parathyroid hormone and parathyroid hormone-related protein in counteracting the detrimental impact of the excess of DAMPs and therefore improving the functional cardiac characteristics especially in the acute phase of the disease. (highwire.org)
Restoration1
- Restoration of calcium homeostasis (balance) prevented hypertrophy (enlargement of heart) and other physiological irregularities. (blogspot.com)
Renal2
- Most often, the increase in renal calcium is generalized, as opposed to the localized increase observed in calcified renal infarct and caseating granulomas of renal tuberculosis. (medscape.com)
- We studied the influence of long-standing Ca-P disregulation on renal transplant survival. (eur.nl)
Aggregation2
- First, experimentation investigates inhibitory capabilities of a group of FDA-approved calcium channel blockers, dihydropyridines, in Aβ aggregation. (sc.edu)
- Erroneous DEPOSITION OF IRON, copper, zinc, or ELEVATION OF CALCIUM in different brain regions can promote Aβ overproduction, tau hyperphosphorylation and their aggregation/accumulation. (wmcresearch.org)
Skeletal1
- Ryanodine receptor 1 (RYR-1) also known as skeletal muscle calcium release channel or skeletal muscle-type ryanodine receptor is one of a class of ryanodine receptors and a protein found primarily in skeletal muscle. (wikipedia.org)
Molecular1
- Can the calcium-regulating hormones counteract the detrimental impact of pro-inflammatory damage-associated molecular patterns in the development of heart failure? (highwire.org)
Hypothesis2
- Early and continued research first revealed the importance of dysregulated calcium levels in the events of AD leading to the Calcium Hypothesis [ 31 , 32 , 48 ]. (biomedcentral.com)
- The Calcium Hypothesis was thus extended as the Calmodulin Hypothesis since CaM not only binds to and regulates CaMBPs critical to learning and memory but also proteins involved in the formation of amyloid plaques and tangles, hallmarks of AD [ 41 ]. (biomedcentral.com)
Processes2
- The abnormal increase in calcium ion concentration within muscle cells activates processes that generate heat (leading to increased body temperature) and produce excess acid (leading to acidosis). (medlineplus.gov)
- In AD experimental models, the intraneuronal calcium concentration is increased, and an elevated calcium level generally appear to be toxic to the cells and it triggers subsequent pathological processes of AD. (wmcresearch.org)
Contribute2
- Designed as an adaptive, regenerative reaction, innate immunity may nevertheless become overactivated and thus contribute to the development of HF by altering the pacemaker rhythm, contraction, and electromechanical coupling, presumably by impairing the calcium homeostasis. (highwire.org)
- 12 Dysregulation of intracellular signaling cascades can contribute to various diseases. (facts.net)
Concentration1
- The resulting increase in calcium ion concentration inside the cells stimulates muscles to contract. (medlineplus.gov)
RYR13
- RYR1 functions as a calcium release channel in the sarcoplasmic reticulum, as well as a connection between the sarcoplasmic reticulum and the transverse tubule. (wikipedia.org)
- RYR1 is associated with the dihydropyridine receptor (L-type calcium channels) within the sarcolemma of the T-tubule, which opens in response to depolarization, and thus effectively means that the RYR1 channel opens in response to depolarization of the cell. (wikipedia.org)
- RYR1 is mechanically linked to neuromuscular junctions for the calcium release-calcium induced biological process. (wikipedia.org)
Common1
- Calcium dysregulation is also common to other neurodegenerative events [ 27 ]. (biomedcentral.com)
Transport1
- Alvares K, Stern PH, Veis A. Dentin Phosphoprotein Binds Annexin 2 and is Involved in Calcium Transport in Rat kidney Ureteric Bud Cells. (chicagobiomedicalconsortium.org)
Cells1
- These cascades form the basis for communication and coordination within cells, allowing them to respond to various external cues and maintain homeostasis. (facts.net)
Results1
- Results of this study showed that calcium dysregulation (calcium elevation) was likely to lead to HCM. (blogspot.com)
Levels1
- Nephrocalcinosis is a condition in which calcium levels in the kidneys are increased. (medscape.com)
Primary1
- Primary Hyperparathyroidism Hypercalcemia is diagnosed when calcium is elevated outside of normal reference ranges. (merckvetmanual.com)