Calcium channels or proteins. Medical search. Frequent questions

Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. (hmdb.ca)
In smooth muscle cells the elevated levels of intracellular calcium cause the opening of BK channels which in turn allow potassium ions to flow out of the cell. (wikipedia.org)
The calcium channel blockers inhibit movement of calcium ions across the cell membrane, depressing both impulse formation (automaticity) and conduction velocity. (medscape.com)
This gene provides instructions for making a protein that is part of a channel that controls the flow of positively charged calcium atoms (calcium ions) within cells. (medlineplus.gov)
A shortage of ITPR1 channels impairs the cell's ability to regulate the concentration of calcium ions. (medlineplus.gov)
It resides in the membrane of the endoplasmic reticulum to channel two types of cargo: protein substrates and calcium ions. (amrita.edu)
Ion channel proteins, for example, are special arrangements of amino acids which embed in the cell membrane (in this case the neuron membrane), and provide passageways for small, polar ions, such as Ca2+ (calcium ions). (pasteur.fr)
The effects of 1-octanol were also abolished by chelation of intracellular calcium ions with 1,2-bis(2-aminophenoxy)ethane- N , N , N ′, N ′-tetraacetic acid. (aspetjournals.org)
The protein, Piezo1, serves as a molecular gate or channel that alternately allows calcium ions into the cell or keeps them out. (nih.gov)

Secondly, it was investigated wheather another protein: the low-density lipoprotein receptor (LDLR)-related protein-1 (LRP1) could also interact with á2ä-1 and TSP. (ucl.ac.uk)
ST13 is also referred to as Hip (Hsp70 interacting protein), p48 (progesterone receptor-associated p48 protein), Hop (Hsp70Hsp90 organizing protein) and SNC6. (calcium-channel.com)
We have used an expression cloning strategy based on calcium influx to isolate a functional cDNA encoding a capsaicin receptor from sensory neurons. (nih.gov)
This receptor is a non-selective cation channel that is structurally related to members of the TRP family of ion channels. (nih.gov)
is compatible with a role in regulating Ca 2+ channel activity or SNARE [soluble N -ethylmaleimide-sensitive factor attachment protein (SNAP) receptor] complex function in vesicle fusion. (jneurosci.org)
These observations presented a spatial and temporal resolution of the sequence of events underlying receptor-evoked involvement of tubulin in G-protein-mediated signaling. (jneurosci.org)
Recent studies propose that N-arachidonyl glycine (NAGly), a carboxylic analogue of anandamide, is an endogenous ligand of the Gα(i/o) protein-coupled receptor 18 (GPR18). (unboundmedicine.com)
The autoantigens include glutamic acid decarboxylase 65 (GAD65), voltage-gated Ca 2+ channel (VGCC), metabotropic glutamate receptor type 1 (mGluR1), and glutamate receptor delta (GluRdelta). (springer.com)
Fast receptor systems, such as the GABAA receptor and the nicotinic receptor at the neuromuscular junction, involve the direct binding of a neurotransmitter to a ligand-gated channel, which opens or closes the channel. (psychiatrictimes.com)
Slower G-protein-linked receptor systems, as seen in the dopaminergic system, work through second-messenger systems, such as cyclic adenosine monophosphate (cAMP), and have a longer duration of action. (psychiatrictimes.com)
In addition to these autoantibodies, patients with thymoma-associated MG produce autoantibodies to various neuromuscular antigens, including antibodies to the skeletal muscle calcium release channel (ryanodine receptor of sarcoplasmic reticulum) and antibodies to cytoplasmic filamentous proteins (particularly titin) or neurofilaments. (medscape.com)

KChIPs are small molecular weight proteins that bind to the cytoplasmic amino termini of Kv4 alpha-subunits and help to modulate its function. (fishersci.com)

Previous studies suggest that the vesicular cysteine-string protein (CSP) may modulate presynaptic Ca 2+ channel activity in fast neurotransmitter release. (jneurosci.org)
Activators of endogenous PKA that stimulate dSlo phosphorylation, but do not produce detectable PKAc binding to dSlo, do not modulate channel function. (elsevierpure.com)
Furthermore, the catalytically inactive PKAc mutant does bind to dSlo but does not modulate channel activity. (elsevierpure.com)
It is suggested that G-protein-coupled receptors might modulate cytoskeletal dynamics, intracellular traffic, and cellular architecture. (jneurosci.org)

á2ä-1 is an auxiliary subunit of the voltage-gated calcium channels, and it regulates the trafficking and functions of the channel complex. (ucl.ac.uk)
The calcium binding domain may be contained in the α subunit sequence, as in KCa1, or may be through an additional calcium binding protein such as calmodulin. (wikipedia.org)
The alpha subunit is a tetramer which forms the pore, the voltage sensor, and the calcium sensing region. (wikipedia.org)
This subunit of the channel is made up of seven trans-membrane units, and a large intracellular region. (wikipedia.org)
The beta subunit of the channel is thought to be a regulatory subunit of the channel. (wikipedia.org)
Drosophila Slowpoke (dSlo) calcium-dependent potassium channels bind directly to the catalytic subunit of cAMP-dependent protein kinase (PKAc). (elsevierpure.com)
Benedetti, B., Benedetti, A., and Flucher, B.E. (2016) Loss of the calcium channel β 4 subunit impairs parallel fiber volley and purkinje cell firing in cerebellum of adult ataxic mice. (i-med.ac.at)
Ca(2+) release-activated Ca(2+) (crac) channel subunit which mediates Ca(2+) influx following depletion of intracellular Ca(2+) stores and channel activation by the Ca(2+) sensor, stim1. (lu.se)

The ryanodine receptors (RyRs) are a family of Ca 2+ channels that mediate the release of Ca 2+ from intracellular Ca 2+ storage organelles. (tocris.com)
Mutants of GPR18, designed to constitutively activate receptors, did not tonically inhibit calcium currents, indicating a lack of GPR18 activation or coupling to endogenous G proteins. (unboundmedicine.com)
Other downstream effectors of Gα(i/o)-coupled receptors, G protein-coupled inwardly rectifying potassium channels and adenylate cyclase, were not modulated by GPR18 signaling. (unboundmedicine.com)
Moreover, many of these channels are receptors for ligands that elicit distinct psychophysical sensations, such as the heat associated with capsaicin and the cold felt with menthol. (nih.gov)
Among these diverse features, it should be acknowledged that auto-antibodies toward glutamate receptors, GABA receptors, and K + channel-related proteins are preferentially found in autoimmune limbic encephalitis but not in IMCAs [ 10 ] (Table 1 ). (springer.com)

These agents may attenuate deleterious effects of calcium influx in patients with acute neurotrauma. (medscape.com)
For example RyR1 is activated following membrane depolarization of skeletal muscle, whereas depolarization of cardiac muscle results in Ca 2+ influx through L-type Ca 2+ channels, which activates RyR2 by CICR. (tocris.com)
Calcium channel blockers (CCBs) are a class of drugs that act by selective inhibition of calcium influx through cellular membranes. (hindawi.com)
2018) Calcium Influx and Release Cooperatively Regulate AChR Patterning and Motor Axon Outgrowth during Neuromuscular Junction Formation. (i-med.ac.at)
Crac channels are the main pathway for Ca(2+) influx in T-cells and promote the immune response to pathogens by activating the transcription factor NFAT. (lu.se)

Researchers at the Institut Pasteur studied the structural organization of synaptic proteins and their influence on the strength of interneuronal communication. (pasteur.fr)
Calcium is a universal signaling molecule in all cells, and for synapses in the brain is responsible for the release of chemical neurotransmitters from synaptic vesicles. (pasteur.fr)
However, the proximity between calcium channel proteins and the synaptic vesicle proteins on which Ca2+ act is critical for regulating the strength and precision of communication. (pasteur.fr)
Thus by studying the nanoscale organization of synaptic proteins we can decipher the molecular code regulating different types of synaptic communication," sums up David DiGregorio. (pasteur.fr)
Until recently, scientists knew that the distance between synaptic proteins must be important, but had little information about the actual two-dimensional nanoscale topographical arrangement of calcium channels and synaptic vesicles, and how it related to the strength and efficiency of synaptic communication. (pasteur.fr)
We hypothesized that the different spatial distribution of these proteins was related to the diversity of synaptic function. (pasteur.fr)
David DiGregorio's team recently combined fluorescence imaging, computational modeling, and electron microscopy, showing in particular that the number of presynaptic calcium channels (CaV) does not correlate with synaptic strength, and that different nanoscale CaV-synaptic vesicle arrangements explain functional differences. (pasteur.fr)
For the first time we show how diversity in the two-dimensional nanotopography of synaptic proteins drives diversity of synaptic strength and its differential modulation by pharmacological compounds. (pasteur.fr)
Distinct Nanoscale Calcium Channel and Synaptic Vesicle Topographies Contribute to the Diversity of Synaptic Function, Neuron , November 20, 2019. (pasteur.fr)
The presence of auto-antibodies that target synaptic machinery proteins was documented recently in immune-mediated cerebellar ataxias. (springer.com)

The generally held view of these processes is that neurotransmitter-induced modulation of the most widely expressed Ca2+ channels in these cells (N-, P/Q- and L-type) follows two distinct pathways: a direct membrane-delimited G(i/o)-protein-induced inhibition of N- and P/Q-type and a remote cAMP-mediated facilitation of L-channels. (unito.it)
Like the N- and P/Q-channels, this autocrine modulation is localized to membrane microareas. (unito.it)
Structurally they are thought to be very similar to BK channels with the main differences being conductance, and the methods of modulation. (wikipedia.org)
These results are consistent with the hypothesis that both binding of active PKAc to dSlo and phosphorylation of dSlo or some other protein are necessary for channel modulation. (elsevierpure.com)
Recent studies show that modulation of TASK-1 channels, either directly or indirectly by targeting their regulatory mechanisms, has the potential to control pulmonary arterial tone in humans. (ersjournals.com)
Here, we recorded T-currents and underlying low-threshold calcium spikes from neurons of nucleus reticularis thalami (nRT) in brain slices from young rats and investigated the mechanisms of their modulation by an anesthetic alcohol, 1-octanol. (aspetjournals.org)
Taken together, these results suggest that inhibition of calcium-dependent PKC signaling is a possible molecular substrate for modulation of T-channels in nRT neurons by 1-octanol. (aspetjournals.org)
GPR18 was heterologously expressed in rat sympathetic neurons, and the modulation of N-type (Ca(v)2.2) calcium channels was examined. (unboundmedicine.com)
Novel identification and modulation of the mechanosensitive Piezo1 channel in human myometrium. (nih.gov)

The first aim of this thesis was to determine whether important functional properties of á2ä-1, such as the ability to regulate calcium currents and binding to GBP, were altered by alternative splicing events on á2ä-1. (ucl.ac.uk)
This finding has sparked further exploration surrounding these channels and researchers have found that IK channels regulate the cell cycle in cancer cells, B and T lymphocytes, and stem cells. (wikipedia.org)
Nicotinic acid adenine dinucleotide phosphate (NAADP) is a second messenger that releases Ca 2+ from acidic organelles through the activation of two-pore channels (TPCs) to regulate endolysosomal trafficking events. (nih.gov)
The Ca 2+ binding proteins, calmodulin and calsequesterin1 are thought to negatively regulate RyR activity, and FK506 binding proteins have been shown to stabilize RyRs in a closed conformation. (tocris.com)
Because most tubulin is not membrane associated, this study investigates whether tubulin translocates to the membrane in response to an agonist so that it might regulate G-protein signaling. (jneurosci.org)
These channels regulate nerve excitability. (medscape.com)

The isoform alpha-1F gives rise to L-type calcium currents. (hmdb.ca)
Then in 1970, Meech was the first to observe that intracellular calcium could trigger potassium currents. (wikipedia.org)
Voltage-gated potassium (Kv) channels are key components of the potassium currents in the heart and central nervous system. (fishersci.com)
Inhibition of both native and recombinant T-currents was accompanied by a hyperpolarizing shift in steady-state inactivation, indicating that 1-octanol stabilized inactive states of the channel. (aspetjournals.org)
To explore the mechanisms underlying higher 1-octanol potency in inhibiting native nRT T-currents, we tested the effect of the protein kinase C (PKC) activator phorbol 12-myristate 13-acetate (PMA) and PKC inhibitors. (aspetjournals.org)
Application of NAGly on GPR18-expressing neurons did not inhibit calcium currents but instead potentiated currents in a voltage-dependent manner, similar to what has previously been reported (Guo et al. (unboundmedicine.com)
Other proposed agonists of GPR18, including anandamide and abnormal cannabidiol, also failed to induce inhibition of calcium currents. (unboundmedicine.com)
Flucher, B.E. and Tuluc, P. (2017) How and why are calcium currents curtailed in the skeletal muscle voltage-gated calcium channels? (i-med.ac.at)

Second, CSP may mediate a direct step of fast neurotransmitter exocytosis independent of Ca 2+ channel activation. (jneurosci.org)

Incidentally the depolarization-induced activation of RyR1 channels in skeletal muscle is dependent on a physical interaction between RyR1 and L-type Ca 2+ channels. (tocris.com)
2019) Correcting the R165K substitution in the first voltage-sensor of Ca V 1.1 right-shifts the voltage-dependence of skeletal muscle calcium channel activation. (i-med.ac.at)
Flucher BE, Campiglio M. (2019) STAC proteins: The missing link in skeletal muscle EC coupling and new regulators of calcium channel function. (i-med.ac.at)

Abcam: antibodies, proteins, kits. (abcam.com)
Antibodies against a presynaptic structure, the voltage-gated potassium channels of peripheral nerves, have been detected in patients with neuromyotonia with or without thymoma. (medscape.com)
Neuromyotonia and antibodies to the voltage-gated potassium channels have also been found in patients with MG. Twenty percent of patients with MG and neuromyotonia have been demonstrated to have thymoma. (medscape.com)

ITPR1 gene mutations likely result in a protein that cannot form stable calcium channels. (medlineplus.gov)
Mutations in K + channel sequences can lead to a variety of clinical disorders exemplifying their physiological importance [ 3 ]. (ersjournals.com)
Human genetic studies have identified mutations in the sodium channel SCN5A gene causing tachyarrhythmia disorders, as well as progressive cardiac conduction system diseases, or overlapping syndromes. (medscape.com)
There are a myriad of mutations identified in genes encoding cardiac transcription factors, ion channels, gap junctions, energy metabolism regulators, lamins and other structural proteins. (medscape.com)

2018) STAC proteins associate to the IQ domain of Ca V 1.2 and inhibit calcium-dependent inactivation. (i-med.ac.at)

Researchers found that it was essential in calcium channel metabolism. (prospecbio.com)
eg, high-protein diets can accelerate metabolism of certain drugs by stimulating cytochrome P-450. (msdmanuals.com)
Deficiency of calcium, magnesium, or zinc may impair drug metabolism. (msdmanuals.com)

First, co-immunoprecipitation and radioligand binding experiments demonstrate that á2ä-1 interacts with thrombospondins (secreted proteins that bind á2ä-1 and promote synaptogenesis) and that this interaction reduces the binding affinity of GBP to á2ä-1. (ucl.ac.uk)

Protein-RNA connections play critical assignments in all respects of gene appearance. (researchdataservice.com)
Autosomal dominant cases of Gillespie syndrome are thought to arise from a dominant-negative effect, which means that the altered protein produced from one copy of the gene interferes with the function of the normal protein produced from the other copy of the gene. (medlineplus.gov)
Leptin, the protein product of the ob gene, is a hormone that is secreted principally by adipose tissue (adipocyte-derived hormone). (researchgate.net)

Below is a list of the 8 known human calcium-activated potassium channel grouped according to sequence homology of transmembrane hydrophobic cores: Though not implied in the name, but implied by the structure these channels can also be activated by voltage. (wikipedia.org)
TWIK-related acid-sensitive potassium channel 1 (TASK-1 encoded by KCNK3) belongs to the family of two-pore domain potassium channels. (ersjournals.com)

When the concentration of free radicals exceeds the neutralizing capability of the body's antioxidants, these highly reactive species can damage vital molecules such as DNA, RNA, enzymes and structural proteins and large amounts of membrane lipids though peroxidation. (nutrametrix.com)
The toxic effects of lead result from its interference with the physiologic actions of calcium, zinc, and iron, through the inhibition of certain enzymes, and through binding to ion channels and regulatory proteins. (cdc.gov)

Calcium channel blockers (CCBs) are drugs in clinical use for hypertension and other heart pathologies. (hindawi.com)

Correction to: Rare variants in ANO1, encoding a calcium-activated chloride channel, predispose to moyamoya disease. (medscape.com)

Using cellular disease models for ADTKD-SEC61A1, we identified an impaired protein transport of the renal secretory protein renin and a reduced abundance of regulatory calcium transporters, including SERCA2. (amrita.edu)

It has been shown to protect critical molecules in the body such as lipids, proteins, and nucleic acids from free radicals and reactive oxygen species (1). (nutrametrix.com)

ATP can also activate RyRs, whilst Mg 2+ is a RyR channel inhibitor. (tocris.com)
In contrast, 12-(2-cyanoethyl)-6,7,12,13-tetrahydro-13-methyl-5-oxo-5 H -indolo(2,3- a )pyrrolo(3,4- c )-carbazole (Go 6976), an inhibitor of calcium-dependent PKC, decreased baseline T-current amplitude in nRT cells and abolished the effects of subsequently applied 1-octanol. (aspetjournals.org)
The effects of mediator modifying drugs, as well as an angiotensin converting enzyme inhibitor (captopril), a calcium channel blocking agent (TMB8) and capsaicin were tested. (cdc.gov)

protein kinase C. (aspetjournals.org)
In the poster section, Joanna Shisler (University of Illinois at Urbana-Champaign [UIUC], Urbana) reported that the modified virus, Ankara, activates nuclear factor κB through the mitogen-activated protein kinase, extracellular signal-regulated kinase (MEK)/extracellular signal-regulated kinase (ERK) pathway, possibly facilitating the host immune response. (cdc.gov)

Wong King Yuen SM, Campiglio M, Tung CC, Flucher BE, Van Petegem F. (2017) Structural insights into binding of STAC proteins to voltage-gated calcium channels. (i-med.ac.at)

2018) Role of putative voltage-sensor countercharge D4 in regulating gating properties of Ca V 1.2 and Ca V 1.3 calcium channels. (i-med.ac.at)

In any muscle cell, increased intracellular calcium causes contraction. (wikipedia.org)

The ST13 may be involved in various types of cancers by regulating the functions of different target proteins through cellular chaperone/co-chaperone pathways [37,38]. (calcium-channel.com)
Author Summary In bacterial cells like in their eukaryotic counterparts precise spatiotemporal localization of proteins is critical for their cellular function. (researchdataservice.com)
Recent studies indicate that T-type calcium channels (T-channels) in the thalamus are cellular targets for general anesthetics. (aspetjournals.org)

In humans they are divided into three subtypes: large conductance or BK channels, which have very high conductance which range from 100 to 300 pS, intermediate conductance or IK channels, with intermediate conductance ranging from 25 to 100 pS, and small conductance or SK channels with small conductances from 2-25 pS. (wikipedia.org)

The protein appeared to have a high affinity for calcium and a much lower affinity for phosphorus and other mineral constituents of the cell. (prospecbio.com)
the thymocytes expressing TCRs that have an excessively high affinity for self-proteins are eliminated. (medscape.com)

Calcium-activated potassium channels are potassium channels gated by calcium, or that are structurally or phylogenetically related to calcium gated channels. (wikipedia.org)

The study authors called for more research to understand how the molecular steps in the Piezo1 channel causes the uterus to relax and whether more substances are involved in the process. (nih.gov)

It is known that IK channels are modulated by calmodulin, whereas BK channels are not. (wikipedia.org)

30°C), TRPM8, a member of the melastatin TRP channel subfamily [ 2 , 3 ]. (nih.gov)

This family of ion channels is, for the most part, activated by intracellular Ca2+ and contains 8 members in the human genome. (wikipedia.org)

Furthermore RyR phosphorylation is thought to induce channel opening, a mechanism that may cause SR calcium leak in the heart. (tocris.com)

Here, we used a "clickable" NAADP-based photoprobe to isolate human NAADP-binding proteins and identified Jupiter microtubule-associated homolog 2 (JPT2) as a TPC accessory protein required for endogenous NAADP-evoked Ca 2+ signaling. (nih.gov)

These compounds stabilize protein channels that would otherwise "leak" calcium from muscle cells during strenuous exercise. (technologyreview.com)

TASK-1 channels are sensitive to a wide array of physiological and pharmacological mediators that affect their activity such as unsaturated fatty acids, extracellular pH, hypoxia, anaesthetics and intracellular signalling pathways. (ersjournals.com)

The interaction of tubulin with these polypeptides involves a GTP transfer from the exchangeable GTP-binding site (E site) of tubulin to Gα, which activates the G-protein (transactivation) ( Roychowdhury and Rasenick, 1994 ). (jneurosci.org)

NAADP action is mediated by NAADP-binding protein(s) of unknown identity that confer NAADP sensitivity to TPCs. (nih.gov)

Researchers at the Institut Pasteur (Paris) recently combined fluorescence imaging, computational modeling, and electron microscopy to show how the diversity of nanoscale protein assemblies drives diversity in communication between neurons in the brain. (pasteur.fr)

Voltage-gated Ca2+ channels are crucial to the control of Ca2+ entry in neurosecretory cells. (unito.it)
In the chromaffin cells of adrenal medulla, paracrinally or autocrinally released neurotransmitters induce profound changes in Ca2+ channel gating and Ca2+-dependent events controlling catecholamine secretion and cell activity. (unito.it)
As L-channels play a crucial role in the control of catecholamine release in chromaffin cells, the two opposite modulations mediated by G(i/o) proteins and cAMP may represent an effective way to broaden the dynamic range of Ca2+ signals controlling exocytosis. (unito.it)
The expression level of this protein is significantly downregulated in colorectal cancer, and increased of ST13 protein expression can suppress the proliferation of colorectal cancer cells. (calcium-channel.com)
These findings indicate that BK channels are involved in the relaxation of smooth muscle cells. (wikipedia.org)
In specialized conducting and automatic cells in the heart, calcium is involved in the generation of the action potential. (medscape.com)
In competent cells MreB was found in complex with several competence proteins by pull-down assays. (researchdataservice.com)
We demonstrate here that coexpression of PKAc with dSlo in mammalian cells results in a dramatic decrease of dSlo channel activity. (elsevierpure.com)
Proper regulation of calcium ion concentration inside cells is important for the development and function of various tissues and organs. (medlineplus.gov)
Centrin is a type of protein that is essential for practically all eukaryotic cells. (prospecbio.com)
Several cancers produce proteins that are physiologically expressed in utero by embryonic and fetal cells but not expressed by normal adult cells. (medscape.com)
In contrast, 1-octanol was up to 30-fold less potent in inhibiting recombinant Ca V 3.3 T-channels heterologously expressed in human embryonic kidney cells. (aspetjournals.org)
When Piezo1 is activated by the protein Yoda1, calcium enters the cells of the myometrium-the smooth muscle making up much of the uterus-causing a cascade of chemical reactions that allow the uterus to stretch. (nih.gov)
In contrast to nonpacemaker cells, SA and AV nodal cells predominantly use calcium channels for the initial upstroke in phase 0 (Fig. 1) and lack sodium ion channels for the rapid initial upstroke in phase 1 of their action potentials. (medscape.com)

In humans, CETN1, CETN2 and CETN3 genes code the protein. (prospecbio.com)

This domain is found in sodium, potassium, and calcium ion channels proteins. (embl.de)

The KCa channel α subunits have six or seven transmembrane segments, similar to the KV channels but occasionally with an additional N-terminal transmembrane helix. (wikipedia.org)
The excitatory beta subunits affect the alpha subunits in such a way that the channel seldom inactivates. (wikipedia.org)
Subtypes of BK Channels KCa1.1 (BK, Slo1, Maxi-K, KCNMA1) Beta subunits: β1, β2, β3, β4 Intermediate conductance channels seem to be the least studied of all of the channels. (wikipedia.org)
The microtubule protein tubulin regulates adenylyl cyclase and phospholipase Cβ 1 (PLCβ 1 ) signaling via transactivation of the G-protein subunits Gαs, Gαi1, and Gαq. (jneurosci.org)

After exhibiting a diffuse localization in the cytoplasm ComGA accumulates preferentially at polar clusters where it co-localizes with other competence proteins to form the transformation machinery [4 13 Upon dilution into fresh medium ComGA stays at the poles for 120 minutes before delocalizing presumably through degradation or inactivation ultimately reversing elongation inhibition [12]. (researchdataservice.com)

The molecular weight of the protein is 20 kDa. (prospecbio.com)

Dysregulation of RyR channel activity has been implicated in the pathogenesis of a number of debilitating muscular diseases. (tocris.com)

Treatment with the molecular chaperone phenylbutyrate reversed the defective protein transport of renin and the imbalanced calcium homeostasis. (amrita.edu)

Vitamin D3 stimulates the induction of calcium-binding proteins, enhancing calcium ion absorption via those channels. (nutrametrix.com)
Severe energy and protein deficiencies reduce tissue enzyme concentrations and may impair the response to drugs by reducing absorption or protein binding and causing liver dysfunction. (msdmanuals.com)

During bacterial exponential growth the morphogenetic actin-like MreB proteins form membrane-associated assemblies that move processively following trajectories perpendicular to the long axis of the cell. (researchdataservice.com)
This study shows that the expression and the localization of the bacterial actin-like MreB protein are growth phase-dependent. (researchdataservice.com)
Among the different classes of proteins regulating bacterial cell elongation the bacterial actin-like MreB proteins have been the most studied over the past fifteen years. (researchdataservice.com)
A bacterial structure of the protein is known for the last two helices but is not included in the Pfam family due to it lacking the first four helices. (embl.de)

Knowing the structure of these channels can provide insight into their function and mechanism of gating. (wikipedia.org)
Regulation of Ca 2+ channels, however, is unlikely to be the only function of CSP. (jneurosci.org)
The function of centrin is to facilitate the duplication of centrioles and severing of microtubules by calcium-mediated contraction. (prospecbio.com)
A family of transmembrane proteins that function primarily as calcium-activated chloride channels. (bvsalud.org)

ER protein determinations were performed using two-thirds of all breast cancers are ER at the time of diagnosis, the standard methods in the routine clinical laboratory (9). (lu.se)

Anatomy29

Organisms13

Diseases2

Chemicals and Drugs162

Analytical, Diagnostic and Therapeutic Techniques and Equipment8

Phenomena and Processes35

Disciplines and Occupations2

Technology, Industry, Agriculture1

Information Science3

Ions9

Receptor11

Cytoplasmic1

Modulate4

Subunit8

Receptors5

Influx5

Synaptic10

Modulation9

Regulate6

Currents8

Neurotransmitter1

Skeletal muscle3

Antibodies3

Mutations4

Inhibit1

Metabolism3

Bind1

Gene3

Potassium channel2

Enzymes2

Blockers1

Chloride channel1

Regulatory1

Reactive oxygen1

Inhibitor3

Kinase2

Structural1

20181

Intracellular calcium1

Cellular3

Small conductance1

High affinity2

Structurally1

Substances1

Calmodulin1

Subfamily1

Activated by intracellular1

Phosphorylation1

Endogenous1

Stabilize1

Pathways1

Activates1

NAADP1

Neurons1

Cells14

Humans1

Sodium1

Subunits4

Machinery1

Molecular weight1

Dysregulation1

Homeostasis1

Absorption2

Bacterial4

Function4

Cancers1