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  • peripheral nociception
  • Although the effective treatment of chronic pain remains elusive, recent findings suggest the importance of T-channels in peripheral nociception, raising the possibility that modulation of those channels might be therapeutic in the treatment of acute ( 6 , 7 ) and chronic ( 8 ) pain. (diabetesjournals.org)
  • Collectively, our data further support a role for Ca v 3.2 channels in peripheral nociception and identify a novel mechanism for Ca v 3.2 modulation that underlies nociceptor sensitization. (jneurosci.org)
  • Pharmacological
  • CONCLUSIONS Our results indicate that pharmacological antagonism of T-channels is potentially an important novel therapeutic approach for the management of painful diabetic neuropathy. (diabetesjournals.org)
  • GVIA
  • N-type calcium channels belong to the 'high-voltage activated' (HVA) group and are blocked by omega-conotoxin-GVIA (omega-CTx-GVIA) and by omega-agatoxin-IIIA (omega-Aga-IIIA). (rcsb.org)
  • which closely matches the properties of a ω-conotoxin GVIA-insensitive calcium channel, which we now call E f channel ( Elmslie, 1997 ). (rupress.org)
  • modulation
  • This study provides the first mechanistic demonstration of a nociceptive ion channel modulation that may contribute to the documented analgesic properties of lipoic acid in vivo . (jneurosci.org)
  • We also studied the molecular basis of T-channel modulation by these oxidizing agents. (jneurosci.org)
  • Thus, separate molecular determinants govern the ability of syntaxin 1A to affect N-type channel gating and its modulation by G-proteins. (jneurosci.org)
  • examine
  • The objective of the study is to examine the mechanisms of SK channel activation in native CMs. (ahajournals.org)
  • To examine the role of calcium channels in depolarization-activated cholecystokinin (CCK) release, studies were performed in an intestinal CCK-secreting cell line, STC-1. (rti.org)
  • Indications
  • The report provides detailed coverage of the pipeline landscape for this mechanism of action, equipped with data from multiple sources with complete pipeline analysis by developmental stage, associated indications, route of administration and molecule type. (reportbuyer.com)
  • proteins
  • Calcium is a common signaling mechanism, as once it enters the cytoplasm it exerts allosteric regulatory affects on many enzymes and proteins. (nih.gov)
  • endogenous
  • Last, we show that reducing agents, as well as synthetic and endogenous Zn 2+ chelators, sensitize Ca v 3.2 current-containing C-type nociceptors from wild-type mice but not C-type nociceptors from Ca v 3.2 −/− mice in vitro and in vivo . (jneurosci.org)
  • selective
  • Moreover, (3β,5α,17β)-17-hydroxyestrane-3-carbonitrile (ECN), a novel neuroactive steroid and selective T-channel antagonist, provided dose-dependent alleviation of neuropathic thermal and mechanical hypersensitivity in diabetic ob/ob mice. (diabetesjournals.org)
  • knockout mice
  • Endothelial function was determined in mesenteric arteries (perfusion) and aortae (isometric contraction) of young and old wild-type (WT), Ca v 3.1, and Ca v 3.2 knockout mice. (springer.com)