Calcium channel antibodies. Medical search. Frequent questions

The following product was used in this experiment: CaV1.2 (CACNA1C) Polyclonal Antibody from Thermo Fisher Scientific, catalog # ACC-003-GP200UL. (thermofisher.com)

Abcam: antibodies, proteins, kits. (abcam.com)
The presence of auto-antibodies that target synaptic machinery proteins was documented recently in immune-mediated cerebellar ataxias. (springer.com)
Among these diverse features, it should be acknowledged that auto-antibodies toward glutamate receptors, GABA receptors, and K + channel-related proteins are preferentially found in autoimmune limbic encephalitis but not in IMCAs [ 10 ] (Table 1 ). (springer.com)
In addition to these autoantibodies, patients with thymoma-associated MG produce autoantibodies to various neuromuscular antigens, including antibodies to the skeletal muscle calcium release channel (ryanodine receptor of sarcoplasmic reticulum) and antibodies to cytoplasmic filamentous proteins (particularly titin) or neurofilaments. (medscape.com)
Proteolytic degradation is critical to the maintenance of appropriate levels of short-lived and regulatory proteins as important and diverse as those involved in cellular metabolism, heat shock and stress response, antigen presentation, modulation of cell surface receptors and ion channels, cell cycle regulation, transcription, and signalling factors. (novusbio.com)
Conversely, low levels of antibodies to neuronal proteins have been reported in patients with sCJD. (bmj.com)
Eighty-two available samples were retested for antibodies to N -methyl- d -aspartate receptor (NMDAR), the glycine receptor (GlyR), voltage-gated potassium channel (VGKC)-complex and the associated proteins, leucine-rich glioma inactivated 1 (LGI1) and contactin-associated protein 2 (CASPR2). (bmj.com)
Sequence analysis reveals that this protein is closely related to two cloned cysteine string proteins of undertermined function that were recently localized to Drosophila nerve terminals using monoclonal antibodies. (xenbase.org)
Flucher BE, Campiglio M. (2019) STAC proteins: The missing link in skeletal muscle EC coupling and new regulators of calcium channel function. (i-med.ac.at)
2018) STAC proteins associate to the IQ domain of Ca V 1.2 and inhibit calcium-dependent inactivation. (i-med.ac.at)
Wong King Yuen SM, Campiglio M, Tung CC, Flucher BE, Van Petegem F. (2017) Structural insights into binding of STAC proteins to voltage-gated calcium channels. (i-med.ac.at)
The present invention relates generally to Transient Receptor Potential Canonical (TRPC) Channel proteins, and more particularly to inhibitors of Transient Receptor Potential Channel 6 (TRPC6) protein activity, pharmaceutical compositions comprising said inhibitors and to methods of using such inhibitors. (justia.com)
Myasthenia gravis is an autoimmune disease: it features antibodies directed against the body's own proteins. (doctorbhatia.com)

We have sought to identify such antibodies, define their specificity, and determine whether they are involved in the development of neurological complications of falciparum malaria. (ox.ac.uk)
The sensitivity and specificity of the VGCC antibody assay are affected by the source of the antigen and the specific laboratory measuring the antibody. (medscape.com)

Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band. (antibodiesinc.com)
Western Blot: LMP7/PSMB8 Antibody [NB120-3329] - Analysis of HeLa cell extract. (novusbio.com)
Western Blot: PARP Antibody (194C1439) - Cleaved [NB100-56599] - Analysis of cleaved PARP in staurosporine-treated Jurkat cells at various time points, antibody at 2 ug/mL. (novusbio.com)
Western Blot: PARP Antibody (194C1439) - Cleaved [NB100-56599] - Analysis using 293T lysates expressing PARP. (novusbio.com)

The following product was used in this experiment: Fyn Monoclonal Antibody (1S) from Thermo Fisher Scientific, catalog # AHO0482, RRID AB_2536311. (thermofisher.com)

Voltage-dependent L-type calcium channel subunit beta-3 or Cav ß3 is encoded by the gene CACNB3. (antibodiesinc.com)
Cavß3 is a cytoplasmic subunit of voltage-sensitive calcium channels.These channels facilitate entry of calcium ions into excitable cells are involved in a variety of calcium dependent processes, including neurotransmitter release, muscle contraction, and gene expression. (antibodiesinc.com)
The α1 subunit pore (~190 kDa in molecular mass) is the primary subunit necessary for channel functioning in the HVGCC, and consists of the characteristic four homologous I-IV domains containing six transmembrane α-helices each. (wikipedia.org)
CACNA1C encodes an alpha-1 subunit of a voltage-dependent calcium channel. (thermofisher.com)
Suppression cloning of the cDNA for a candidate subunit of a presynaptic calcium channel. (xenbase.org)
A novel strategy, termed suppression cloning, was used to identify a 7.4 kb cDNA encoding a putative subunit of the calcium channels that regulate transmitter release at nerve endings of Torpedo californica. (xenbase.org)
Benedetti, B., Benedetti, A., and Flucher, B.E. (2016) Loss of the calcium channel β 4 subunit impairs parallel fiber volley and purkinje cell firing in cerebellum of adult ataxic mice. (i-med.ac.at)
Description: A sandwich ELISA kit for detection of Calcium Channel, Voltage Dependent, T-Type, Alpha 1H Subunit from Mouse in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (operatiebrp.nl)

Monoclonal antibody that targets CGRP. (medscape.com)
This monoclonal antibody specifically detects a 89-kDa cleavage fragment containing the catalytic and auto modification domain. (novusbio.com)
The blot was probed with Anti-Fyn Mouse Monoclonal Antibody (Product # MA1-12607, 1-3 µg/mL) and detected by chemiluminescence using Goat anti-Mouse IgG (H+L) Superclonal™ Secondary Antibody, HRP conjugate (Product # A28177, 0.4 µg/mL, 1:2500 dilution). (thermofisher.com)

In any patient consulting for RP, assessment includes at least an antinuclear antibody test and capillaroscopy. (iasp-pain.org)

The treatment of RP is essentially documented for secondary RP where calcium channel blockers are indicated in first line, and iloprost in severe cases. (iasp-pain.org)
The treatment of primitive erythermalgia is based on sodium channel blockers such as mexiletine or lidocaine infusions, and on drugs effective on neuropathic pain, such as gabapentin or amitryptiline, in case of erythermalgia associated with small fiber neuropathy. (iasp-pain.org)
Potassium channel blockers. (uky.edu)
thus, diag- -agonists, calcium channel blockers, mal heart rate response in some nosis relies heavily on results of labo- or xanthine derivatives. (cdc.gov)
Standard advanced life support plus sodium bicarbonate is appropriate for life-threatening dysrhythmias caused by cocaine or other sodium channel blockers. (medscape.com)

Here, we show that, in a cohort of Kenyan children, levels of antibodies to the voltage-gated calcium channels, but not to other ion channels, increased with the severity of malaria infection. (ox.ac.uk)

Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. (abcam.com)

Diagnosis is by measurement of serum acetylcholine receptor (AChR) antibody levels, electromyography, and bedside tests (ice pack test, rest test). (msdmanuals.com)
About 10 to 20% of patients with generalized myasthenia have no antibodies to acetylcholine receptors (AChR) in serum. (msdmanuals.com)
It is an autoimmune disorder, in which weakness is caused by circulating antibodies that block acetylcholine receptors at the post-synaptic neuromuscular junction, [1] inhibiting the stimulative effect of the neurotransmitter acetylcholine. (doctorbhatia.com)
Some forms of the antibody impair the ability of acetylcholine to bind to receptors. (doctorbhatia.com)

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase. (thermofisher.com)

5% patients with sCJD develop serum antibodies to these neuronal antigens and, when positive, only at low titres. (bmj.com)
Conversely, there have been occasional reports of patients presenting with encephalopathy and low levels of serum antibodies to neuronal protein such as the N -methyl- d -aspartate receptor (NMDAR), voltage-gated potassium channel complex (VGKC-complex) or glycine receptor (GlyR), who were later confirmed to have sporadic CJD (sCJD). (bmj.com)
Although the absence of NMDAR antibodies in 346 referred cerebrospinal fluid (CSF) samples, including samples from 49 confirmed sCJD cases 4 was reported recently, the frequency of disease-relevant serum antibodies in patients with sCJD prior to diagnosis, and how frequently an incorrect CJD diagnosis could have been averted, have not been studied systematically. (bmj.com)

Despite their immune diversity, the majority of IMCAs is commonly associated with auto-antibodies against cerebellar autoantigens. (springer.com)
An IV of antibodies from plasma helps some patients' immune systems stop attacking. (uky.edu)
Immunomodulatory for both humoral and cellular immune mechanisms, it inhibits complement activity by binding the first component of complement, neutralizing C3a and C5a, thought specific to antibody. (nursingcenter.com)
Peripheral nerve damage of either the myelin or axon is mediated by an immune cascade involving cytokines, monocytes, and complement-fixing antibodies. (nursingcenter.com)
Digoxin-specific immune antibody fragments can reverse life-threatening dysrhythmias from digoxin poisoning. (medscape.com)

Presynaptic Ca V 2.2 (N-type) calcium channels are subject to modulation by interaction with syntaxin 1 and by a syntaxin 1-sensitive Gα O G-protein pathway. (jneurosci.org)
However, the G-protein exhibited a punctate staining on the calyx membrane with an intensity that varied in synchrony with that for both Ca channels and syntaxin 1 but only weakly with MUNC18-1. (jneurosci.org)
Previous reports have demonstrated that this channel type can be inhibited via two pathways that involve syntaxin 1 and G-protein. (jneurosci.org)
The above findings could be explained if syntaxin 1 was a key element of a protein complex at the transmitter release site that included N-type Ca channels and Gα O . The primary motivation for this study was to test this hypothesis. (jneurosci.org)
The CGI component is attributed to the binding of the Ca2+-binding signaling protein calmodulin (CaM) to at least 1 site on the channel, as Ca2+-null CaM mutants abolish CGI in L-type channels. (wikipedia.org)
Unlike other channels, opening of the pore is due to the repositioning of tethered pore-lining helices within a surrounding protein shell that dramatically widens a neck of the pore through a concertina of amino acid rearrangements. (elifesciences.org)
We found that Homer3, the predominant isoform in Purkinje cells, is phosphorylated by calcium/calmodulin-dependent protein kinase II (CaMKII) both in vitro and in vivo . (jneurosci.org)
In this study, we revealed that Homer3 was phosphorylated by calcium/calmodulin-dependent protein kinase II (CaMKII) in Purkinje cells, and the phosphorylation reduces the affinity for Homer target molecules, resulting in change of the solubility. (jneurosci.org)
In rodents and other mammals this gene product is found in the cytoplasm localized with a calcium channel membrane protein, and is thought to play a role in brain development. (antibodies-online.com)
Effects of inhibition of AGEs on coronary artery tensions and BK channel densities and protein expression (a) Representative tracings for 60 mmol/L KCl and 100 nmol/L IBTX induced vascular tension alterations of coronary arterial rings from C+V, DM+V, C+A and DM+A groups. (bioz.com)

SMI312 antibody) and somatodendritic marker (i.e. (calcium-channel.com)

Objectives There have been reports of patients with antibodies to neuronal antigens misdiagnosed as sporadic Creutzfeldt-Jakob disease (sCJD). (bmj.com)

The autoantigens include glutamic acid decarboxylase 65 (GAD65), voltage-gated Ca 2+ channel (VGCC), metabotropic glutamate receptor type 1 (mGluR1), and glutamate receptor delta (GluRdelta). (springer.com)
Rapid changes in electrophysiology and intracellular calcium provide evidence for a membrane-bound progesterone receptor in these cells, in addition to classical cytoplasmic receptors. (uni-muenchen.de)
ACh receptor (AChR) antibodies are most commonly associated with myasthenia gravis (MG) and are occasionally found in low titers in LEMS. (medscape.com)
Up to 50% of these AChR antibody‒negative patients have antibodies to muscle-specific receptor tyrosine kinase (MuSK), a surface membrane enzyme that helps AChR molecules aggregate during development of the neuromuscular junction. (msdmanuals.com)
TRPM7 (Transient receptor potential cation channel, subfamily M, member 7) is a divalent cation channel permeable to calcium and magnesium. (neuromics.com)
The TRPC6 channel, a member of the Transient receptor potential (TRP) family, which is a non-selective cation-permeable channel, is activated by diacylglycerol and the like produced by activation of phospholipase C and exerts physiological and pathophysiological effects. (justia.com)

GAD65 is involved in the synthesis, packaging, and release of GABA, whereas the other three play important roles in the induction of long-term depression (LTD). Thus, the auto-antibodies toward these synaptic molecules likely impair fundamental synaptic machineries involved in unique functions of the cerebellum, potentially leading to the development of cerebellar ataxias (CAs). (springer.com)
Anti-GAD65 antibody (Ab) acts on the terminals of inhibitory neurons that suppress GABA release, whereas anti-VGCC, anti-mGluR1, and anti-GluR Abs impair LTD induction. (springer.com)
Second, these antibodies impair the induction of synaptic plasticity, rebound potentiation, and LTD, on Purkinje cells, resulting in loss of restoration and compensation of the distorted "internal models. (springer.com)

2019) Correcting the R165K substitution in the first voltage-sensor of Ca V 1.1 right-shifts the voltage-dependence of skeletal muscle calcium channel activation. (i-med.ac.at)
Flucher, B.E. and Tuluc, P. (2017) How and why are calcium currents curtailed in the skeletal muscle voltage-gated calcium channels? (i-med.ac.at)

The clone number has been updated from S57-46 to L57/46, both clone numbers name the same antibody clone. (abcam.com)
The antibodies are raised in Mouse and are from clone IG266. (science-bas.org)

D amyloid- (MOAB2 antibody) pathology in hippocampal strata containing the axons and neuronal cell bodies of your CA3-Schaffer collateral and dentate granule-mossy fiber pathways. (calcium-channel.com)
Low titres of neuronal antibodies occur only rarely in suspected patients with sCJD and when present should be interpreted with caution. (bmj.com)

The only true methods of differentiating MG from LEMS are the detection of AChR antibodies and the presence of underlying malignancy. (medscape.com)
However, anti-MuSK antibodies do not occur in most patients with AChR antibodies or with isolated ocular myasthenia. (msdmanuals.com)
The clinical significance of anti-MuSK antibodies is still under study, but patients with these antibodies are much less likely to have thymic hyperplasia or a thymoma, may be less responsive to anticholinesterase drugs, and may require more aggressive early immunotherapy than patients who have AChR antibodies. (msdmanuals.com)
2018) Calcium Influx and Release Cooperatively Regulate AChR Patterning and Motor Axon Outgrowth during Neuromuscular Junction Formation. (i-med.ac.at)

N-type (Ca V 2.2) Ca channels are known to play an important role in the gating of transmitter release at presynaptic terminals. (jneurosci.org)
Evidence for syntaxin 1-dependent Ca channel inhibition in intact nerve terminals has recently been indicated in synaptosomes ( Bergsman and Tsien, 2000 ) and was shown directly by the effect of syntaxin 1 cleavage with botulinum toxin C1 on the presynaptic Ca current ( Stanley, 2003 ). (jneurosci.org)
We noted that botulinum-mediated cleavage of syntaxin essentially eliminated the inhibition of presynaptic Ca channels via the Gα O -gated pathway ( Stanley and Mirotznik, 1997 ). (jneurosci.org)
Antibodies against a presynaptic structure, the voltage-gated potassium channels of peripheral nerves, have been detected in patients with neuromyotonia with or without thymoma. (medscape.com)

This antibody was developed by immunizing mice with a synthetic peptide containing amino acids near 214/215-cleavage site of human PARP. (novusbio.com)

[ 1 ] These criteria are based on the presence or absence of cancer, the presence of well-characterized paraneoplastic (onconeural) antibodies, and the type of clinical syndrome. (medscape.com)
A nonclassical neurological syndrome, no paraneoplastic antibodies, and cancer that presents within 2 years of the neurological syndrome. (medscape.com)
Unfortunately, in some cases these antibodies cross-react with normal tissues and destroy them, which may result in a paraneoplastic disorder. (medscape.com)
The detection of paraneoplastic anti-neural antibody was first reported in 1965. (medscape.com)

Immunocytochemistry/ Immunofluorescence: PARP Antibody (194C1439) - Cleaved [NB100-56599] - A431 cells were fixed for 10 minutes using 10% formalin and then permeabilized for 5 minutes using 1X PBS + 0.5% Triton-X100. (novusbio.com)

Activation of particular VGCCs allows a Ca2+ influx into the cell, which, depending on the cell type, results in activation of calcium-sensitive potassium channels, muscular contraction, excitation of neurons, up-regulation of gene expression, or release of hormones or neurotransmitters. (wikipedia.org)
Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization. (thermofisher.com)
This antibody was raised to a membrane-bound antigen involved in calcium influx subsequent to progesterone binding in sperm. (uni-muenchen.de)

It also limits terminal complement complex formation on target membranes, interferes with the ability of the specific host antibody to bind to a target antigen, and modulates the ability of B cells to produce antibody. (nursingcenter.com)

In autoimmune limbic encephalitis, it is assumed that these auto-antibodies diffusely interfere with basal synaptic transmission or neural excitability and weaken overall functions of the temporal lobe [ 18 ]. (springer.com)
For more information about laboratory testing for autoimmune neurologic diseases, including detailed information about panel test selection, refer to the ARUP Consult Autoimmune Neurologic Diseases - Antineural Antibody Testing topic. (arupconsult.com)
To compare these panels and the antibodies included, refer to ARUP Autoimmune Neurology Panel Components . (arupconsult.com)
Over the same period three patients with autoimmune encephalitis and high VGKC-complex antibodies were initially referred as sCJD. (bmj.com)
By contrast, three patients referred with possible prion disease had a clinical picture in keeping with autoimmune encephalitis and very high VGKC-complex/LGI1 antibodies. (bmj.com)

Sera of 40 scleroderma sufferers and 15 wholesome controls have been examined for IgG and IgM anti-annexin V antibodies by ELISA and anticentromere antibodies by oblique immunofluorescence. (ncbcs.org)

Find CRBN Antibodies with a specific conjugate such as Alexa Fluor 350, Alexa Fluor 488, Alexa Fluor 555. (antibodies-online.com)

these antibodies bind to AChRs on the postsynaptic membrane at the neuromuscular junction and interrupt neuromuscular transmission. (msdmanuals.com)

This antibody recognizes epitope aa 26-75. (thermofisher.com)
Find CRBN Antibodies with a specific epitope. (antibodies-online.com)

Bulk Order Inquiry for Anti-Cavbeta4 Ca2+ Channel Antibody FL490 Conjugate ------- (please add any order requirements, including desired quantity, timing, etc. (antibodiesinc.com)

Antineural antibodies serve as useful markers of these diseases, and their detection may help establish a diagnosis, support treatment decisions, aid prognostication, serve as a prerequisite for enrollment in clinical trials, and guide the search for an associated malignancy. (arupconsult.com)

Over 500 products have been investigated for neuroprotective effects including those from the categories of free radical scavengers, anti-excitotoxic agents, apoptosis (programmed cell death) inhibitors, anti-inflammatory agents, neurotrophic factors, metal ion chelators, ion channel modulators, and gene therapy. (researchandmarkets.com)

A thryoid-stimulating hormon assay, a test for antinuclear antibodies, and a search for small fiber neuropathy are also performed. (iasp-pain.org)

Antibodies to voltage-gated calcium channels in children with falciparum malaria. (ox.ac.uk)

Igg Antibody Laboratories manufactures the antibody with two igg reagents distributed by Genprice. (science-bas.org)

Auto-antibodies induced neurological diseases show various clinical phenotypes (see details in Table 1 ). (springer.com)

These channels regulate nerve excitability. (medscape.com)

These channels are slightly permeable to sodium ions, so they are also called Ca2+-Na+ channels, but their permeability to calcium is about 1000-fold greater than to sodium under normal physiological conditions. (wikipedia.org)
The concentration of calcium (Ca2+ ions) is normally several thousand times higher outside the cell than inside. (wikipedia.org)

Excessive activation of VGCCs is a major component of excitotoxicity, as severely elevated levels of intracellular calcium activates enzymes which, at high enough levels, can degrade essential cellular structures. (wikipedia.org)
Progesterone (0.1-10 mu M) was applied to cultured thymulin-secreting thymic epithelial cells (TS-TEC) and changes in transmembrane potential, transmembrane current, intracellular calcium levels and thymulin secretion were assessed. (uni-muenchen.de)
Intracellular calcium levels, monitored by the ratiometric fluorescent calcium indicator fura-2, increased within seconds of progesterone (1 mu M) application. (uni-muenchen.de)

Conjugated primary antibodies with 490 nm, 550 nm, 594 nm, and 650 nm fluorophores! (antibodiesinc.com)
Primary Antibodies are guaranteed for 1 year from date of receipt. (novusbio.com)

The presence of anti-phospholipid antibodies (aPL) have been outlined by our in-house ELISA strategies. (ncbcs.org)
Anti-annexin V antibodies have been measured with ELISA in 177 VOC and 81 steady-state SCA sufferers. (ncbcs.org)
Find CRBN Antibodies validated for a specific application such as IF (cc), IF (p), WB, ELISA. (antibodies-online.com)

Find CRBN Antibodies for a variety of species such as anti-Mouse CRBN, anti-Rat CRBN, anti-Human CRBN. (antibodies-online.com)

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans. (antibodiesinc.com)

Voltage-gated calcium channels (VGCCs), also known as voltage-dependent calcium channels (VDCCs), are a group of voltage-gated ion channels found in the membrane of excitable cells (e.g., muscle, glial cells, neurons, etc.) with a permeability to the calcium ion Ca2+. (wikipedia.org)
This effect was reduced in the presence of cobalt chloride which blocks voltage-dependent calcium channels. (uni-muenchen.de)

We used this method to demonstrate that at the nerve terminal syntaxin is a part of two different complexes: one associated with the N-type channel and Gα O at the release site, as predicted, and a second much more prominent complex with MUNC18 that appears to be remote from the release sites. (jneurosci.org)
[ 9 ] For example, antibodies or T cells directed against the tumor may mistakenly attack normal nerve cells. (medscape.com)

However, at present, the presence of antibodies to components of the CNS during malaria infection has not been reported. (ox.ac.uk)
Testing for the presence of antineural antibodies in both serum and CSF is recommended in most situations. (arupconsult.com)
Biochemical fractionation with phosphor-specific antibodies revealed the presence of phosphorylated Homer3 in the cytosolic fraction in contrast to high levels of nonphosphorylated Homer3 in PSD. (jneurosci.org)
Your blood will be tested for the presence of anti-voltage-gated calcium channels antibodies, which are found in 85% of LEMS patients. (uky.edu)
In view of their prothrombotic nature, we hypothesized that SCA-associated VOC could also be because of the presence of anti-annexin V antibodies. (ncbcs.org)
We investigated the prevalence of anti-annexin V IgG and IgM antibodies in sera of scleroderma sufferers and their relation to the presence of different antibodies and improvement of illness morbidity. (ncbcs.org)

When a tumor arises, the body may produce antibodies to fight it by binding to and destroying tumor cells. (medscape.com)

Centrifuge all antibody preparations before use (10000 X g 5 min). (thermofisher.com)

Anatomy13

Organisms10

Diseases2

Chemicals and Drugs111

Analytical, Diagnostic and Therapeutic Techniques and Equipment12

Phenomena and Processes26

Disciplines and Occupations3

Information Science3

Polyclonal Antibody1

Proteins13

Specificity2

Western blot4

Thermo Fisher Sci1

Subunit8

Monoclonal antibody3

Antinuclear antibody1

Blockers5

Levels of antibodies1

Recombinant1

Acetylcholine4

Datasheet1

Serum antibodies3

Immune5

Protein10

Marker1

Antigens1

Receptor6

Impair3

Skeletal2

Clone2

Neuronal2

AChR4

Presynaptic4

Synthetic Peptide1

Paraneoplastic4

Immunocytochemistry1

Influx3

Antigen1

Autoimmune5

Immunofluorescence1

Alexa Fluor1

Neuromuscular junction1

Epitope2

Conjugate1

Diagnosis1

Inhibitors1

Assay1

Falciparum malaria1

Laboratories1

Neurological1

Regulate1

Ions2

Intracellular3

Primary2

ELISA3

Species1

Reagents1

Voltage-dependent calcium channels2

Nerve2

Presence6

Tumor1

Preparations1