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  • cells
  • They observed that targeting the Ca 2+ -binding protein parvalbumin to the nucleus significantly reduced cell proliferation and altered the proportions of cells that were in the S and G 2 -M phases of the cell cycle. (biologists.org)
  • In some cell types (nonmuscle cells), it is generally accepted that the outer nuclear membrane and ER have similar characteristics and outer nuclear membrane is continuous with ER membrane including SERCA, whereas the inner nuclear membrane is quite different from the outer nuclear membrane. (ahajournals.org)
  • The present study examined the effects of N- hydroxy- N ′-(4-butyl-2 methylphenyl) formamidine (HET0016), a selective inhibitor of the formation of 20-hydroxyeicosatrienoic acid (20-HETE) on the growth of 9L rat gliosarcoma cells in vitro and in vivo. (aspetjournals.org)
  • vitro
  • To compare kinase substrate preferences more generally, we employed a proteomic display technique that allowed comparison of complex cell extracts phosphorylated by each kinase in a rapid in vitro assay, thereby demonstrating substrate preferences that overlapped but were clearly distinct. (duke.edu)
  • CAMK2
  • CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. (uniprot.org)
  • CAMK2 is composed of 4 different chains: alpha ( CAMK2A ), beta ( CAMK2B ), gamma ( CAMK2G ), and delta ( CAMK2D ). (rcsb.org)
  • mesh
  • In addition, the relatively rigid sarcomeric organization in striated muscle with a dense protein mesh at the Z-lines raises the possibility that local SR within a given sarcomere could serve its particular sarcomere but not necessarily communicate with neighboring sarcomeres either longitudinally or transversely. (ahajournals.org)
  • Calcium-Calmodulin-Dependent Protein Kinases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (ucdenver.edu)
  • mice
  • To investigate the renoprotective effects of DBM in type 2 diabetes, we administered DBM (100 mg/kg) orally for 12 weeks to high-fat diet-induced diabetic model mice. (bioscientifica.com)
  • actin
  • In neurons, plays an essential structural role in the reorganization of the actin cytoskeleton during plasticity by binding and bundling actin filaments in a kinase-independent manner. (rcsb.org)
  • PAB denotes a single parallel, contractile actin bundle containing α-actinin-4, myosin 9, and synaptopodin. (nih.gov)
  • Enzymes
  • Although importance of PLC enzymes for key cellular functions is well established, the PLC proteins belonging to the ε, ζ and η subfamilies were identified and characterized only during the last decade. (jcancer.org)
  • transcriptional
  • We show that phosphomimetic mutation of Thr 149 (T149D) dramatically increases AP-1 transcriptional activity while alanine mutation does not affect transcriptional activity when compared with wild-type (WT) ΔFosB. (jneurosci.org)
  • Recombinant
  • To validate this approach, one of the proteins labeled in this assay was identified by microsequencing as HSP25, purified as a recombinant protein, and examined as a substrate for both CaMKI and CaMKIV. (duke.edu)
  • nucleus
  • 4 The NucEn surrounds the nucleus and has both an inner and an outer membrane and a space in between where [Ca 2+ ] can be millimolar. (ahajournals.org)
  • Cellular
  • As a largest known PLC protein, PLCε is involved in a variety of signaling pathways and controls different cellular properties. (jcancer.org)
  • IP3 stimulates Ca 2+ signaling and DAG acts through protein kinase C (PKC) leading to different cellular events, such as proliferation, growth and migration. (jcancer.org)
  • function
  • p>This subsection of the 'Function' section describes a region in the protein which binds nucleotide phosphates. (uniprot.org)
  • sequences
  • The tool works with standard single letter nucleotide or protein codes including ambiguities and can match Prosite patterns in protein sequences. (nih.gov)
  • Differing serotypes of AAV possess divergent capsid protein sequences and these variations greatly influence each serotype's ability to transduce particular cell types and brain regions. (readbyqxmd.com)
  • HUMAN
  • The aim of this review is to provide a comprehensive and up-to-date overview of the experimental and clinical data about the role of PLCε in the development and progression of the different types of human and experimental tumors. (jcancer.org)