aaaaxxxCalcium calmodulin dependent protein kinase type 1. Medical search. FAQ
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  • metabolism
  • According to blast screening and functional annotation, 20.2% and 20.9% of genes were related to metabolism proteins, 9% and 3.6% to transporters and channels, 16% and 6.3% to transcription factors, 19% and 17.2% to hypothetical proteins, and finally 24.1 and 17.2% to unknown genes, from the down- and up-regulated libraries, respectively. (mdpi.com)
  • We demonstrate that insulin resistance and DM associate with reduced expression of multiple nuclear respiratory factor-1 ( NRF-1 )-dependent genes encoding key enzymes in oxidative metabolism and mitochondrial function. (pnas.org)
  • It may act as an atypical peroxiredoxin-like peroxidase, a redox-dependent chaperone, and a regulator of transcription and RNA metabolism ( 3 ). (pubmedcentralcanada.ca)
  • transients
  • Measurements of nuclear and cytosolic Ca 2+ transients in IP 3 sponge mice showed no increase of Ca 2+ levels during diastole as we detected in wild-type mice. (springer.com)
  • substrate
  • These results indicate that the auto-inhibitory domain in CaMKI gates, in a Ca(2+)-CaM dependent fashion, accessibility of both substrates to the substrate binding cleft and CaMKI kinase to Thr177. (duke.edu)
  • catalytic
  • The autoinhibitory domain overlaps with the calmodulin binding region and interacts in the inactive folded state with the catalytic domain as a pseudosubstrate. (abcam.cn)
  • 1998
  • PLCε homologue in C. elegans , PLC210 protein was first discovered in 1998 by Kataoka and coworkers by using a yeast two-hybrid system with Ras homologous protein LET-60 as the bait [ 3 ]. (jcancer.org)
  • Influence
  • Over the past 15 years or so, numerous studies have sought to characterise how nuclear calcium (Ca 2+ ) signals are generated and reversed, and to understand how events that occur in the nucleoplasm influence cellular Ca 2+ activity, and vice versa. (biologists.org)
  • Differing serotypes of AAV possess divergent capsid protein sequences and these variations greatly influence each serotype's ability to transduce particular cell types and brain regions. (readbyqxmd.com)
  • MeSH
  • In addition, the relatively rigid sarcomeric organization in striated muscle with a dense protein mesh at the Z-lines raises the possibility that local SR within a given sarcomere could serve its particular sarcomere but not necessarily communicate with neighboring sarcomeres either longitudinally or transversely. (ahajournals.org)
  • species
  • If you would like to see the shared identity between different species or other proteins, follow the link in the Accession field, select the sequence (make sure that you are selecting the sequence that you are interested in, as the sequence may be the precursor rather than the mature protein for example) and copy and paste it HERE and blast/format it. (biosensis.com)
  • computational_description=CONTAINS InterPro DOMAIN/s: CBL-interacting protein kinase (InterPro:IPR020660)%2C Calcium/calmodulin-dependent protein kinase-like (InterPro:IPR020636)%3B BEST Arabidopsis thaliana protein match is: unknown protein (TAIR:AT5G47170.1)%3B Has 176 Blast hits to 176 proteins in 20 species: Archae - 0%3B Bacteria - 0%3B Metazoa - 0%3B Fungi - 0%3B Plants - 176%3B Viruses - 0%3B Other Eukaryotes - 0 (source: NCBI BLink). (salk.edu)
  • computational_description=GRF1-interacting factor 2 (GIF2)%3B CONTAINS InterPro DOMAIN/s: SSXT (InterPro:IPR007726)%3B BEST Arabidopsis thaliana protein match is: GRF1-interacting factor 3 (TAIR:AT4G00850.1)%3B Has 425 Blast hits to 425 proteins in 91 species: Archae - 0%3B Bacteria - 4%3B Metazoa - 291%3B Fungi - 20%3B Plants - 89%3B Viruses - 0%3B Other Eukaryotes - 21 (source: NCBI BLink). (salk.edu)
  • The inducible loss of DJ-1 triggers the establishment of hypoxia and the production of reactive oxygen species that stabilize the hypoxia-inducible factor-1α (HIF-1a). (pubmedcentralcanada.ca)
  • intracellular
  • As with every cell, the ability of the podocyte to receive signals from the surrounding environment and to translate them to the intracellular milieu is dependent largely on molecules residing on the cell membrane. (nih.gov)
  • In addition, propofol induced intracellular calcium concentration, and activated CaMKII as well as PKCβ. (springer.com)
  • bind
  • Interestingly, four of them are able to bind calmodulin among which the IP3 kinase A (ITPKA) and pregnancy up-regulated non-ubiquitously expressed CaM kinase (PNCK, also named CaMKIβ). (nih.gov)
  • CaMKI 1-306, was unable to bind Ca(2+)-CaM and was completely inactive thereby defining an essential component of the CaM-binding domain to residues C-terminal to 306. (duke.edu)
  • CaMKI 1-294 did not bind CaM but was fully active in the absence of Ca(2+)-CaM, indicating that residues 295-306 are sufficient to maintain CaMKI in an auto-inhibited state. (duke.edu)
  • membrane
  • Podocyte plasma membrane proteins and a canonical pattern of injury. (nih.gov)
  • 1 Electrical depolarization of the cell membrane opens L-type Ca 2+ channels, causing Ca 2+ influx. (ahajournals.org)
  • Core domain of PLCε is responsible for the hydrolysis of membrane phosphoinositides into second messengers inositol-1,4,5-phosphate and diacylglycerol (DAG) [ 4 - 6 , 8 ]. (jcancer.org)
  • Enzyme
  • Protein arginine N-methyltransferase 3 (PRMT3) is a cytoplasmic enzyme that utilizes S-adenosyl-L-methionine (AdoMet) to methylate specific proteins, most of which contain GAR (glycine-arginine rich) motifs. (readbyqxmd.com)
  • chelator
  • In spite of its importance as a tool to manipulate cell calcium, the versatility of the octadentate chelator BAPTA in cell physiological and diverse other applications is limited by. (naver.com)
  • Importantly, the Ang II-mediated effects were diminished by α-tocopherol, and the propofol-mediated effects were alleviated by calcium chelator, CaMKII inhibitor, and PKCβ inhibitor. (springer.com)
  • cellular
  • Although importance of PLC enzymes for key cellular functions is well established, the PLC proteins belonging to the ε, ζ and η subfamilies were identified and characterized only during the last decade. (jcancer.org)
  • As a largest known PLC protein, PLCε is involved in a variety of signaling pathways and controls different cellular properties. (jcancer.org)
  • IP3 stimulates Ca 2+ signaling and DAG acts through protein kinase C (PKC) leading to different cellular events, such as proliferation, growth and migration. (jcancer.org)
  • pathology
  • Reduction in post-synaptic scaffolding PSD-95 and SAP-102 protein levels in the alzheimer inferior temporal cortex is correlated with disease pathology. (springer.com)
  • diabetes
  • Diabetic nephropathy (DN) is one of the most frequent microvascular complications of diabetes mellitus, and develops in 15-40% of patients with Type 1 and Type 2 diabetes. (mdpi.com)
  • The course of renal disease might be similar for both types of diabetes. (mdpi.com)
  • Type 2 diabetes mellitus (DM) is characterized by insulin resistance and pancreatic β cell dysfunction. (pnas.org)
  • Insulin resistance precedes and predicts the development of type 2 diabetes mellitus (DM) ( 1 , 2 ). (pnas.org)
  • A significant association of rs10906115 in CDC123 (zeige CDC123 Antikörper )/ CAMK1D and rs1359790 near SPRY2 (zeige SPRY2 Antikörper ) was identified with type 2 diabetes in a Japanese population. (antikoerper-online.de)