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  • long-term potenti
  • This structural function is required for correct targeting of CaMK2A, which acts downstream of NMDAR to promote dendritic spine and synapse formation and maintain synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. (rcsb.org)
  • CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. (uniprot.org)
  • plasticity
  • In neurons, plays an essential structural role in the reorganization of the actin cytoskeleton during plasticity by binding and bundling actin filaments in a kinase-independent manner. (rcsb.org)
  • Nucleotide
  • The tool works with standard single letter nucleotide or protein codes including ambiguities and can match Prosite patterns in protein sequences. (nih.gov)
  • p>This subsection of the 'Function' section describes a region in the protein which binds nucleotide phosphates. (uniprot.org)
  • Human
  • Recombinant human CAMK4 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography. (antikoerper-online.de)
  • target
  • a href='/help/protein_existence' target='_top'>More. (uniprot.org)
  • As the elderly population has worse functional recovery after stroke, our data suggested that this protein may be a potential target for reducing long term disability of stroke patients. (ahajournals.org)