• The aim of this study was to investigate the expression and silencing of the S100A8 gene, which encodes the S100 calcium-binding protein A8 (S100A8), and apoptosis and phosphorylation of protein kinase B (Akt) in tissue samples of endometrial carcinoma and HEC-1A endometrial adenocarcinoma cells in vitro . (medscimonit.com)
  • EF-hand Ca2+-binding proteins (CBPs), such as calmodulin (CaM) or those belonging to the S100 protein family (S100s) undergo conformational changes upon increasing intracellular Ca2+, facilitating interactions with protein targets and inducing important biological responses. (umaryland.edu)
  • This research seeks to elucidate both the mechanisms of allostery and the basis of ligand- and target- specificity for S100 proteins and CaM. (umaryland.edu)
  • First, molecular fragments were used to differentiate between two highly similar S100 proteins, S100B and S100A1, with the goal of designing S100-specific inhibitors to block these elevated S100 proteins in various disease states. (umaryland.edu)
  • This provided insight into the specificity of S100A1 versus S100B for small molecules and will enable improved S100 protein-based drug design efforts. (umaryland.edu)
  • The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. (cancerindex.org)
  • S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. (cancerindex.org)
  • The most ubiquitous Ca2+-sensing protein, found in all eukaryotic organisms including yeasts, is calmodulin. (wikipedia.org)
  • In both the SmTAL and FhCaBP families, the proteins also differ in their ability to bind calmodulin antagonists and related drugs. (brighton.ac.uk)
  • Calcium regulation of chloroplast protein translocation is mediated by calmodulin binding to Tic32. (ox.ac.uk)
  • Regulatory circuits include redox-control as well as calcium-regulation, with calmodulin being the likely mediator of the latter. (ox.ac.uk)
  • Using affinity-chromatography on calmodulin-agarose, we could identify the inner envelope translocon component Tic32 as the predominant calmodulin-binding protein of this membrane. (ox.ac.uk)
  • Calmodulin-binding assays corroborate the interaction for heterologously expressed as well as native Tic32. (ox.ac.uk)
  • The interaction is calcium-dependent and is mediated by a calmodulin-binding domain between Leu-296 and Leu-314 close to the C-proximal end of the pea Tic32. (ox.ac.uk)
  • In particular, binding of NADPH and calmodulin to Tic32 appear to be mutually exclusive. (ox.ac.uk)
  • This gene is similar to the oncomodulin gene, a high-affinity calcium ion-binding protein that belongs to the superfamily of calmodulin proteins, also known as the EF-hand proteins. (nih.gov)
  • DEL1 protects against chondrocyte apoptosis through integrin binding. (uchicago.edu)
  • Several putative binding partners of ALG-2 have been identified hinting to functions of ALG-2 in apoptosis and possibly also in proliferation, endocytosis and transcriptional regulation during development. (imrpress.com)
  • These data suggest a working mechanism for the release of CED-4 from the CED-4/CED-9 complex upon EGL-1 binding and provide a mechanistic framework for understanding apoptosis activation in C. elegans. (nih.gov)
  • The various markers that enable assessment of the progression of preneoplastic lesions to spindle cell carcinoma include the p16 protein, which halts the cell cycle and induces apoptosis by pRb-mediated phosphorylation of cyclin-dependent kinase 4 (CDK4). (bvsalud.org)
  • The biologic function of LKB1 includes the regulation of downstream kinases, including adenosine monophosphate-activated protein kinase (AMPK) and the related kinases (microtube affinity-regulating kinase [MARK] 1 through MARK4 and brain-specific kinase/synapses of the amphid-defective kinase [Brsk/SAD]), which are involved in cellular metabolic regulation-stress response and cellular polarity, the latter through tubulin stabilization, tight junction formation, and E-cadherin localization. (medscape.com)
  • Drosophila Slowpoke (dSlo) calcium-dependent potassium channels bind directly to the catalytic subunit of cAMP-dependent protein kinase (PKAc). (elsevierpure.com)
  • PKG: protein kinase G. (frontiersin.org)
  • Also, another member of the EF-hand superfamily is the S100B protein, which regulates p53. (wikipedia.org)
  • Calcium is involved in most cellular processes through calcium-binding proteins, belonging to the EF-hand superfamily. (edu.pl)
  • Parvalbumin is a glycoprotein that belongs to calcium binding family of EF-hand superfamily of proteins. (usda.gov)
  • SCPP genes are recognized by exon structure rather than protein sequence. (wikipedia.org)
  • Even though these proteins have very high sequence similarity, they bind to different target proteins in a Ca2+ dependent manner, leading to different functional pathways (Yadava et al. (rcsb.org)
  • Parvalbumin has a highly conserved amino acid sequence and shows high percentage of identity among different fish species, making this protein the most common cause of cross reactivity in fish allergy. (usda.gov)
  • The import of nuclear-encoded proteins into chloroplasts is tightly controlled on both sides of the envelope membranes. (ox.ac.uk)
  • This protein is found in basement membranes, which are thin, sheet-like structures that support cells in many tissues and help anchor cells to one another during embryonic development. (medlineplus.gov)
  • May act as a scaffolding protein within caveolar membranes. (aacrjournals.org)
  • The secretory calcium-binding phosphoprotein (SCPP) gene family consists of an ancient group of genes emerging around the same time as bony fish. (wikipedia.org)
  • What does this gene/protein do? (cancerindex.org)
  • Huntington's disease (HD) is a severe autosomal-dominant neurodegenerative disorder caused by a mutation within a gene, encoding huntingtin protein. (frontiersin.org)
  • At the molecular level, HD occurs due to an increase in the number of CAG repeats in the first exon of the gene encoding the huntingtin protein. (frontiersin.org)
  • The SMOC1 gene provides instructions for making a protein called secreted modular calcium-binding protein 1 (SMOC-1). (medlineplus.gov)
  • SMOC1 gene mutations often result in a nonfunctional SMOC-1 protein. (medlineplus.gov)
  • Mutations in the SPARC-related modular calcium-binding protein 1 gene, SMOC1, cause waardenburg anophthalmia syndrome. (medlineplus.gov)
  • Silver J, Yalcindag C, Sela-Brown A, Kilav R, Naveh-Many T. Regulation of the parathyroid hormone gene by vitamin D, calcium and phosphate. (medscape.com)
  • A novel PAX3 heterozygous mutation of c.372-373delGA (p.N125fs) was found that gave rise to a frameshift and truncation of the PAX3 protein. (medscape.com)
  • One of the functions of calcium binding proteins is to regulate the amount of free (unbound) Ca2+ in the cytosol of the cell. (wikipedia.org)
  • The SMOC-1 protein attaches (binds) to many different proteins and is thought to regulate molecules called growth factors that stimulate the growth and development of tissues throughout the body. (medlineplus.gov)
  • Cells carefully regulate the levels of chaperone proteins. (elifesciences.org)
  • S100B proteins are abundantly found in cancerous tumor cells causing them to be overexpressed, therefore making these proteins useful for classifying tumors. (wikipedia.org)
  • S100A1 and S100B binding to ions was also compared and differences between ion binding sites within the two highly similar proteins were determined. (umaryland.edu)
  • There is a family of proteins from parasitic worms which combine N-terminal EF-hand domains with C-terminal dynein light chain-like domains. (brighton.ac.uk)
  • P53 is known as a tumor suppressor protein and in this case acts as a transcriptional activator or repressor of numerous genes. (wikipedia.org)
  • Thus, stress response studies during these growth stages reveal novel differentially regulated genes or proteins with important functions in plant stress adaptation. (intechopen.com)
  • An atypical pulmonary fibrosis is associated with co-inheritance of mutations in the calcium binding protein genes S100A3 and S100A13 . (bvsalud.org)
  • The effect of CaM on multiple full-length target proteins was then discussed to further describe CaM allostery. (umaryland.edu)
  • Elevated total serum calcium levels are associated with idiopathic hypercalcemia, vitamin D intoxication, hyperparathyroidism, sarcoidosis, pneumocystic carinii pneumonia, and blue diaper syndrome. (cdc.gov)
  • Ionized calcium is interpreted in conjunction with the total serum calcium measurement. (medscape.com)
  • Calcium is essential for bone mineralization, neuromuscular function, and secretion of hormones and enzymes. (medscape.com)
  • The toxic effects of lead result from its interference with the physiologic actions of calcium, zinc, and iron, through the inhibition of certain enzymes, and through binding to ion channels and regulatory proteins. (cdc.gov)
  • 2016, Thesis, Calcium-Dependent Membrane-Binding and Localization of Copine Proteins in Dictyostelium. (cmich.edu)
  • Calcium-Dependent Membrane-Binding and Localizatio. (cmich.edu)
  • Abnormalities of proximal tubular function included reduced reabsorption of beta-2-microglobulin, retinol binding protein, calcium and phosphate. (cdc.gov)
  • These include lead's ability to inhibit or mimic the actions of calcium (which can affect calcium-dependent or related processes) and to interact with proteins (including those with sulfhydryl, amine, phosphate, and carboxyl groups) [ATSDR 2010]. (cdc.gov)
  • They can act as transport proteins, regulator proteins, or activator proteins. (uchicago.edu)
  • For example, the neuron-specific calexcitin has been found to have an excitatory effect on neurons, and interacts with proteins that control the firing state of neurons, such as the voltage-dependent potassium channel. (wikipedia.org)
  • Subpopulations of cholinergic, GABAergic and glutamatergic neurons in the pedunculopontine nucleus contain calcium-binding proteins and are heterogeneously distributed. (ox.ac.uk)
  • We have shown that calcium signaling is dramatically disturbed in HD76 neurons, specifically demonstrating higher levels of store-operated and voltage-gated calcium uptakes. (frontiersin.org)
  • However, comparing the HD76 neurons with the previously described low-repeat HD models, we have demonstrated that the severity of calcium signaling alterations does not depend on the length of the polyglutamine tract of the mutant huntingtin. (frontiersin.org)
  • Here we have also observed greater expression of huntingtin and an activator of store-operated calcium channels STIM2 in HD76 neurons. (frontiersin.org)
  • Activators of endogenous PKA that stimulate dSlo phosphorylation, but do not produce detectable PKAc binding to dSlo, do not modulate channel function. (elsevierpure.com)
  • These results are consistent with the hypothesis that both binding of active PKAc to dSlo and phosphorylation of dSlo or some other protein are necessary for channel modulation. (elsevierpure.com)
  • The Ca2+-tightening of these CBPs is described here by the "binding and functional folding" framework for detailing this physiologically relevant phenomenon. (umaryland.edu)
  • To gain further insight into the molecular composition of these three populations in the rat, we investigated the pattern of expression of calcium binding proteins (CBPs) across distinct regions of the PPN and in relation to the presence of other neurochemical markers. (ox.ac.uk)
  • Due to its ability to bind calcium with high affinity it was postulated to provide a link between the known effect of calcium in programmed cell death and the molecular death execution machinery. (imrpress.com)
  • It also indicates that in addition to freely diffusing through the cytoplasm to attain a homogeneous distribution, calcium binding proteins can bind to cellular structures through interactions that are likely important for their functions. (wikipedia.org)
  • STK11/LKB1 encodes a 433 amino acid ubiquitously expressed protein with a central catalytic domain and regulatory N- and C-terminal domains. (medscape.com)
  • These were found to consist of adjacent protomers engaging the interdomain linker of one molecule in the substrate binding site of another, attenuating the chaperone function of oligomeric BiP. (elifesciences.org)
  • The experiments show that oligomers form when the interdomain linker of one BiP molecule is bound to the region of an adjacent BiP molecule that is normally reserved for binding to unfolded proteins. (elifesciences.org)
  • Calcium-binding proteins are proteins that participate in calcium cell signaling pathways by binding to Ca2+, the calcium ion that plays an important role in many cellular processes. (wikipedia.org)
  • Calcium binding proteins also serve an important physiological role for cells. (wikipedia.org)
  • This type of protein is also found in large quantities in malignant mesothelial cells, which can be easily differentiated from carcinomas. (wikipedia.org)
  • Compartmentalization of calcium binding proteins such as calretinin and calbindin-28 kDa has been noted within cells, suggesting that these proteins perform distinct functions in localized calcium signaling. (wikipedia.org)
  • Roy A, Mondal S, Kordower JH, Pahan K. Attenuation of microglial RANTES by NEMO-binding domain peptide inhibits the infiltration of CD8(+) T cells in the nigra of hemiparkinsonian monkey. (rush.edu)
  • Here we demonstrate that the C-terminal half of EGL-1 is necessary and sufficient for binding to CED-9 and for killing cells. (nih.gov)
  • The SMOC-1 protein also likely promotes the maturation (differentiation) of cells that build bones, called osteoblasts . (medlineplus.gov)
  • Further experiments challenged cells with chemicals that caused the number of unfolded proteins in the cells to increase. (elifesciences.org)
  • However, when the levels of unfolded proteins rise, cells can rapidly break up these oligomers to make active monomers that help to deal with the excess numbers of unfolded proteins. (elifesciences.org)
  • Further work is needed to understand how changes in the number of unfolded proteins in cells leads to the formation and disassembly of BiP oligomers. (elifesciences.org)
  • Cystatin A (Cys A), a cysteine protease inhibitor, is a precursor of proteins involves in keratinocyte keratinization, and is expressed during the late phase of differentiation of these cells. (bvsalud.org)
  • Comparative anatomical distribution of neuronal calcium-binding protein (NECAB) 1 and -2 in rodent and human spinal cord. (scilifelab.se)
  • Neuronal calcium-binding protein 1 and -2 (NECAB1/2) localize to multiple excitatory neuron populations in the mouse spinal cord. (scilifelab.se)
  • Calcium-Binding Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (uchicago.edu)
  • The protein appears to be highly conserved throughout these evolutionarily diverse strains and may be important in the virulence of the organism. (kzoo.edu)
  • Several allergens have been identified and characterized from different fish species, parvalbumin, as a highly conserved protein, is the most common causative agent of fish-borne allergies. (usda.gov)
  • While at the college, Wasserman studied the mechanisms of mineral ion transport, focusing on the function of vitamin D on intestinal absorption of calcium and phosphorus. (cornell.edu)
  • Parathyroid hormone raises serum calcium by increasing renal tubular calcium reabsorption, increasing intestinal calcium absorption, and increasing bone turnover. (medscape.com)
  • The role of calcium-binding proteins in the control of transcription: structure to function" (PDF). (wikipedia.org)
  • This review article discusses the current knowledge on the structure and potential function of this protein. (imrpress.com)
  • This protein may function in exocytosis and endocytosis. (cancerindex.org)
  • Calcium moderates nerve and muscle performance by regulating the action potential excitation threshold and facilitating normal cardiac function. (medscape.com)
  • In addition, this explains why this protein can easily interact with p53 when transcriptional regulation takes place. (wikipedia.org)
  • These results suggest that redox modulation and calcium regulation of chloroplast protein import convene at the Tic translocon and that both could be mediated by Tic32. (ox.ac.uk)
  • These strategies involve rearrangements at the molecular level starting from transcription, regulation of mRNA processing, translation, and protein modification or its turnover. (intechopen.com)
  • Conclusion: p63, p16, MIB, Cal A, Cys A are markedly expressed and p16 is strongly suppressed in oral cavity tumors, which suggests that the latter protein may play a role in negative regulation of cell cycle progression. (bvsalud.org)
  • Another protein, calgranulin A (Cal A), is involved in the regulation of several cell processes, including the cell cycle and cell differentiation. (bvsalud.org)
  • Another study revealed an allosteric mechanism in which a peptide termed BP2, derived from the STRA6 vitamin A transporter, increased the Ca2+-binding affinity of CaM upon binding. (umaryland.edu)
  • The p63 protein, a homologue of p53, may be associated with tumor formation in the epithelial tissue, acting as an oncogene 11,12 . (bvsalud.org)
  • Yamamoto M, Kawanobe Y, Takahashi H, Shimazawa E, Kimura S, Ogata E. Vitamin D deficiency and renal calcium transport in the rat. (medscape.com)
  • These proteins can be present in a cell as single molecules (monomers) or as a group of several chaperone molecules (oligomers). (elifesciences.org)
  • Many different calcium-binding proteins exist, with different cellular and tissue distribution and involvement in specific functions. (wikipedia.org)
  • Functions of these proteins and their relations to some neurological diseases are reviewed. (edu.pl)
  • dSlo binds to free PKAc but not to the PKA holoenzyme that includes regulatory subunits and is inactive. (elsevierpure.com)
  • Wasserman would make foundational discoveries in this line of study, including the identification and characterization of calcium-binding protein, known today as calbindin. (cornell.edu)