AnatomyDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentHealth Care
Dermatologic AgentsCalcitriolPsoriasisOintmentsPetrolatumCoal TarScalp DermatosesBetamethasoneAdministration, TopicalAllantoinNicotinic AcidsNail DiseasesPharmaceutical VehiclesGelsAdministration, CutaneousCholecalciferolKeratinocytesDrug CombinationsAnti-Inflammatory AgentsDrug Administration ScheduleTreatment Outcome
Betamethasone dipropionateTopicalAdult weekly dose of calcipotriolVitaminMechanism of calcipotriolOintment contains 50DifferentiationDovobetScalpEfficacyPsoriasis VulgarisTSLPDaivobetMedicationPreparationsMetabolitesHypercalcaemiaEffectivenessSystemicDosesToxicityCorticosteroidIrritationProliferationSkinDoseDipropionateCreamPatientsExcessiveManufacturerMedicationsSafetyMedicalBody surf
Betamethasone dipropionate7
  • Calcipotriol is also available as Calcipotriol/betamethasone dipropionate, a fixed-dose combination medication with the synthetic corticosteroid betamethasone dipropionate for the treatment of plaque psoriasis. (wikipedia.org)
  • Calcipotriol/Betamethasone Dipropionate in Psoriasis" Encyclopedia , https://encyclopedia.pub/entry/17039 (accessed December 01, 2023). (encyclopedia.pub)
  • Preparations containing calcipotriol combined with betamethasone dipropionate (in the forms of ointment, gel, and foam) are available for the topical treatment of psoriasis. (encyclopedia.pub)
  • Pharmacodynamic studies showed the anti-inflammatory and immunoregulatory synergy of the combination of calcipotriol and betamethasone dipropionate with respect to the effects of these active substances administered individually [ 4 ] . (encyclopedia.pub)
  • The effectiveness of calcipotriol/betamethasone dipropionate mixtures is related to a synergy of action of the two substances. (encyclopedia.pub)
  • Calcipotriol/betamethasone dipropionate aerosol foam is a new psoriasis treatment option that is rapidly effective, offers greater efficacy versus ointment and gel formulations, and has been shown to increase patient treatment satisfaction. (skintherapyletter.com)
  • Dovobet ointment is used for treating constant plaque psoriasis and has two active ingredients, betamethasone dipropionate and calcipotriol hydrate. (doctorsolve.com)
Topical8
  • In mouse studies, topical calcipotriol administration to the ear and dorsal skin led to a dose-dependent increase in the production of the epithelial cell-derived cytokine TSLP by keratinocytes, and triggered atopic dermatitis at high concentrations. (wikipedia.org)
  • Topical calcipotriol plus 5-fluorouracil (5-FU) combination is an effective immunotherapy against actinic keratosis (AK), which is a precursor to squamous cell carcinoma (SCC). (kanker-actueel.nl)
  • We performed a blinded prospective cohort study on participants of a randomized double-blind clinical trial in which a 4-day course of topical calcipotriol plus 5-FU combination was compared to Vaseline plus 5-FU (control) for AK treatment. (kanker-actueel.nl)
  • A synthetic vitamin D derivative usually formulated for topical dermatological use, antipsoriatic Calcipotriene (calcipotriol) competes equally with active 1,25-hydroxy-2D3 (the natural form of vitamin D) for 1,25-hydroxy-2D3 receptors in regulating cell proliferation and differentiation. (chemwatch.net)
  • Avoid excessive exposure to either artificial or natural sunlight during therapy, as animal studies have suggested that topical calcipotriol may enhance the effect of UV radiation to induce skin tumours. (medscape.co.uk)
  • I've just reviewed a report showing incredible hair growth results from use of topical Calcipotriol. (nicehair.org)
  • An 8 year old boy with sudden rapid hair loss was treated with topical Calcipotriol. (nicehair.org)
  • Long-term efficacy and tolerability of topical calcipotriol in psoriasis. (medicaljournals.se)
Adult weekly dose of calcipotriol2
  • When used concurrently with calcipotriol scalp application, the total adult weekly dose of calcipotriol should not exceed 5mg. (medscape.co.uk)
  • The maximum adult weekly dose of calcipotriol - betamethasone combined is 100 grams. (medbroadcast.com)
Vitamin14
  • Calcipotriol, also known as calcipotriene, is a synthetic derivative of calcitriol, a form of vitamin D.[medical citation needed] It is used in the treatment of psoriasis. (wikipedia.org)
  • Hypersensitivity, use on face, hypercalcaemia, or evidence of vitamin D toxicity are the only contraindications for calcipotriol use. (wikipedia.org)
  • The efficacy of calcipotriol in the treatment of psoriasis was first noticed by the observation of patients receiving various forms of vitamin D in an osteoporosis study. (wikipedia.org)
  • This upregulation of TSLP production due to calcipotriol application is thought to be mediated through the coactivation of vitamin D receptor/RXRα and vitamin D receptor/RXRβ heterodimers. (wikipedia.org)
  • Calcipotriol is a vitamin D3 analog that displays minimal effects on calcium homeostasis. (fishersci.com)
  • Calcipotriol is a low-calcemic vitamin D receptor (VDR) agonist. (adooq.com)
  • This study investigated the effect of calcipotriol, a synthetic vitamin D3 analogue that avoids hypercalcaemia, on human rectal CCPR in ulcerative proctocolitis. (uea.ac.uk)
  • Calcipotriol, a synthetic vitamin D3 analogue, has a similar mode of action to calcitriol-changing the expression of genes responsive to vitamin D. It binds to the retinoid X receptor and influences cell differentiation and growth regulation, immune functions, and the balance of calcium and phosphorus in the body [ 1 ] . (encyclopedia.pub)
  • Calcipotriol (also known as calcipotriene) is a synthetic form of vitamin D3. (nicehair.org)
  • Calcipotriol belongs to the class of medications known as vitamin D analogues and works by controlling the excessive production of skin cells seen in psoriasis. (medbroadcast.com)
  • Early research shows that applying a specific cream containing avocado oil and vitamin B12 (Regividerm, Regeneratio Pharma AG, Wuppertal, Germany) to the skin for 12 weeks reduces symptoms of psoriasis as effectively as a conventional medication called calcipotriol ointment (Psorcutan). (rxlist.com)
  • Calcipotriol is derived from vitamin D and helps in reducing the production of skin cells. (doctorsolve.com)
  • Calcipotriol is a non-calcaemic vitamin D3 analogue. (medicaljournals.se)
  • Ointments such as coal tar, anthralin, non-steroidal vitamin D3 (calcipotriol), and steroid creams are also useful. (pediatriconcall.com)
Mechanism of calcipotriol2
  • The precise mechanism of calcipotriol in remitting psoriasis is not well understood. (wikipedia.org)
  • The mechanism of calcipotriol/betamethasoneantipsoriatic activity has remained only partially known for a long time. (encyclopedia.pub)
Ointment contains 502
  • Each gram of faintly translucent white-to-yellowish ointment contains 50 µg of calcipotriol plus 0.5 mg of betamethasone (as dipropionate). (medbroadcast.com)
  • One gram of ointment contains 50 micrograms of calcipotriol (as monohydrate) and 0.5 mg of betamethasone (as dipropionate). (medicines.org.uk)
Differentiation4
  • T cells are known to play a role in psoriasis, and it is thought that the binding of calcipotriol to the VDR modulates the T cells gene transcription of cell differentiation and proliferation related genes. (wikipedia.org)
  • Calcipotriol promotes the differentiation of keratinocytes. (fishersci.com)
  • In human T cells and in psoriatic skin, Calcipotriol increases IL-10 secretion, induces secretion of type 2 cytokines by T cells and modulates the differentiation of dendritic cells and T cells. (fishersci.com)
  • Calcipotriol affects keratinocyte differentiation, while betamethasone influences inflammatory processes and minimizes skin irritation (e.g., pruritus) after calcipotriol application [ 5 ] . (encyclopedia.pub)
Dovobet1
  • Due to the content of calcipotriol Dovobet is contra-indicated in patients with known disorders of calcium metabolism (see section 4.4). (medicines.org.uk)
Scalp3
  • Accordingly, significantly more epidermal Trm cells persisted in the calcipotriol plus 5-FU-treated face and scalp skin compared with control ( P = 0.0028). (kanker-actueel.nl)
  • A short course of calcipotriol plus 5-FU treatment on the face and scalp is associated with induction of robust T cell immunity and Trm formation against AKs and significantly lowers the risk of SCC development within 3 years of treatment. (kanker-actueel.nl)
  • When preparations used together maximum total calcipotriol 3.75mg in any one week for children 12-18 years (e.g. 30ml scalp solution with 45g cream or ointment). (medscape.co.uk)
Efficacy1
  • The purpose of the present study was to determine the efficacy and safety of calcipotriol ointment in patients treated for approximately 6 months. (medicaljournals.se)
Psoriasis Vulgaris1
  • In short-term studies, topically applied calcipotriol is both efficacious and safe for the treatment of psoriasis vulgaris. (medicaljournals.se)
TSLP2
  • As psoriasis is typically thought to be partially driven by Th1/Th17 inflammatory cytokines, calcipotriol treatment at appropriate concentrations may alleviate psoriasis symptoms by repressing Th1/Th17 inflammation through TSLP production, which is linked to a Th2 response. (wikipedia.org)
  • Calcipotriol suppresses skin cancer development in mice in a thymic stromal lymphopoietin (TSLP)-dependent manner. (fishersci.com)
Daivobet1
Medication2
  • Wash your hands after applying calcipotriol - betamethasone so that you do not get the medication on other parts of your body. (medbroadcast.com)
  • If you need a stronger medication, your dermatologist may prescribe calcipotriol or another medication. (aad.org)
Preparations1
  • Limited absorption is expected after local application of calcipotriol preparations to small areas. (medscape.co.uk)
Metabolites1
  • The metabolites of calcipotriol are less potent than the parent compound. (wikipedia.org)
Hypercalcaemia1
  • The risk of hypercalcaemia is minimal when the recommendations relevant to calcipotriol are fulfilled. (medscape.co.uk)
Effectiveness2
  • However, the long-term effectiveness of calcipotriol plus 5-FU treatment for SCC prevention is unknown. (kanker-actueel.nl)
  • The Calcipotriol are widely appreciated in the international market for their accurate composition and effectiveness. (chemvonbiotech.com)
Systemic1
  • After application and systemic uptake, calcipotriol undergoes rapid hepatic metabolism. (wikipedia.org)
Doses1
  • Use of the recommended doses of calcipotriol does not lead to a disturbance in calcium homeostasis. (medscape.co.uk)
Toxicity1
  • Risk of environmental impact of calcipotriol cannot be excluded, due to the lack of environmental toxicity. (janusinfo.se)
Corticosteroid1
  • Your dermatologist may prescribe one or more of these medications, which you can apply at home: Corticosteroid, pimecrolimus, tacrolimus, or calcipotriol. (aad.org)
Irritation1
  • The avocado combination cream also causes less irritation than calcipotriol. (rxlist.com)
Proliferation1
  • Williamson, R C. / Calcipotriol inhibits rectal epithelial cell proliferation in ulcerative proctocolitis . (uea.ac.uk)
Skin4
  • Tissues were analyzed for calcipotriol plus 5-FU-induced T cell immunity in the skin. (kanker-actueel.nl)
  • Calcipotriol is particularly effective in treating psoriasis by helping to regulate the growth and development of skin cells. (nicehair.org)
  • Calcipotriol works by controlling the excessive production of skin cells seen in psoriasis. (pharmasave.com)
  • Calcipotriol reduces excessive skin cell production and helps improve these symptoms of psoriasis. (doctorsolve.com)
Dose3
  • Clinical experience in children has shown calcipotriol to be safe and effective over eight weeks with wide variability in dose, but a mean dose of 15g per week. (medscape.co.uk)
  • When using calcipotriol containing medicinal products, the maximum daily dose should not exceed 15 g. (medicines.org.uk)
  • The maximum weekly adult dose of calcipotriol ointment is 100 g (5 mg of calcipotriol). (pharmasave.com)
Dipropionate1
  • Each gram of almost clear, colourless-to-slightly-off-white gel contains 50 µg of calcipotriol plus 0.5 mg of betamethasone (as dipropionate). (medbroadcast.com)
Cream1
  • Patients were randomized to 1% benvitimod cream (n = 344), 0.005% calcipotriol ointment (n = 169), or placebo (n = 173) twice a day for 12 weeks. (medscape.com)
Patients2
  • Paired rectal biopsy specimens from seven patients with severe disease were established in organ culture with or without calcipotriol (1 x 10(-6) M). After 15 hours, vincristine (0.6 microgram/ml) was added to induce metaphase arrest, and CCPR was determined by linear regression analysis of accumulated metaphases. (uea.ac.uk)
  • Manufacturer advises that calcipotriol is contraindicated in patients with severe renal impairment. (medscape.co.uk)
Excessive1
  • Cautions include exposure to excessive natural or artificial light, due to the potential for calcipotriol to cause photosensitivity. (wikipedia.org)
Manufacturer1
  • Manufacturer states that the safety of calcipotriol use during pregnancy has not been established and that its use should be avoided. (medscape.co.uk)
Medications1
Safety1
  • Safety of calcipotriol use during human pregnancy has not been established. (medscape.co.uk)
Medical1
Body surf1
  • The body surface area treated with calcipotriol containing medicinal products should not exceed 30 % (see section 4.4). (medicines.org.uk)