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  • Cartilage
  • This support mechanism becomes dysregulated in aging cartilage, where extracellular PP(i) excess, mediated in part by upregulated NPP1 expression stimulates calcification. (nih.gov)
  • This model presents mechanisms underlying the common association of extracellular PPi excess with both CPPD and HA crystal deposition in OA and chondrocalcinosis cartilages, as well as the paradoxical association of extracellular PPi deficiency (from defective ANK or PC-1/NPP1 expression) with pathologic calcification of articular cartilage with HA crystals in vivo. (nih.gov)
  • Also illustrated at the top of this schematic is the role in cartilage calcification in OA and aging of altered TGFβ expression and responsiveness, which drives PPi generation and release mediated via NPP1 and ANK, and diminished responsiveness to IGF-I, which normally suppresses elevation of chondrocyte extracellular PPi. (nih.gov)
  • Cells
  • The mDE6 cells expressed odontogenesis-related genes, such as Runx2, Amelx, Ambn and Enam, and formed calcified matrices upon the induction of calcification, thus showing characteristics of odontogenic epithelial cells. (nih.gov)
  • The expression of odontogenesis-related genes, and the calcification of the mDE6 cells were reduced by the inhibition of phosphorylated Smad1/5 (p-Smad1/5) and phosphorylated Akt (p-Akt) proteins. (nih.gov)
  • Furthermore, we used siRNA against Tb4 to determine whether RUNX2 expression and calcification are associated with Tb4 expression in the mDE6 cells. (nih.gov)
  • These results suggest that Tb4 is associated with RUNX2 expression through the Smad and PI3K-Akt signaling pathways, and with calcification through RUNX2 expression in the mDE6 cells. (nih.gov)
  • The dura mater contained multiple areas of fibrosis and calcification with rare, multinucleated giant cells adjacent to the foci of calcification ( Fig 2 ). (ajnr.org)
  • Effects of traditional chinese medicine Drynaria fortunei smith on promoting the proliferation, differentiation and calcification of mouse osteoblastic MC3T3-E1 cells]. (naver.com)
  • expression
  • Balance in PP(i) generation relative to PP(i) degradation by pyrophosphatases holds extracellular PP(i) levels in check.Moreover, physiologic levels of extracellular PP(i) suppress hydroxyapatite crystal growth, but concurrently providing a reservoir for generation of pro-mineralizing P(i).PP(i) generated by NPP1modulates not only hydroxyapatite crystal growth but also chondrogenesis and expression of the mineralization regulator osteopontin. (nih.gov)
  • Head CT
  • Head CT demonstrated progressive dural calcifications, whereas MR imaging demonstrated progressive dural thickening and enhancement during a 3-year period in which the patient received several gadolinium-enhanced MR imaging studies. (ajnr.org)
  • Head CT scan obtained in June 2006 demonstrated diffuse dural calcification ( Fig 3 ). (ajnr.org)
  • Head CT scan in March 2008 demonstrated progressive calcification ( Fig 5 ). (ajnr.org)
  • Also, some tumors have calcification a which can be seen in a head ct. (healthtap.com)
  • brain
  • We have recently described two endothelial enzymes within the brain vasculature that promote platelet aggregation and calcification. (yale.edu)
  • Axial noncontrast CT image at the level of the tentorium in brain windows and magnified image at the level of the lateral ventricles in bone windows demonstrate diffuse dural calcification ( arrows on magnified image ). (ajnr.org)